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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CXCL2-CXCL2 (FusionGDB2 ID:HG2920TG2920)

Fusion Gene Summary for CXCL2-CXCL2

check button Fusion gene summary
Fusion gene informationFusion gene name: CXCL2-CXCL2
Fusion gene ID: hg2920tg2920
HgeneTgene
Gene symbol

CXCL2

CXCL2

Gene ID

2920

2920

Gene nameC-X-C motif chemokine ligand 2C-X-C motif chemokine ligand 2
SynonymsCINC-2a|GRO2|GROb|MGSA-b|MIP-2a|MIP2|MIP2A|SCYB2CINC-2a|GRO2|GROb|MGSA-b|MIP-2a|MIP2|MIP2A|SCYB2
Cytomap('CXCL2')('CXCL2')

4q13.3

4q13.3

Type of geneprotein-codingprotein-coding
DescriptionC-X-C motif chemokine 2GRO2 oncogeneMGSA betaMIP2-alphachemokine (C-X-C motif) ligand 2gro-betagrowth-regulated protein betamacrophage inflammatory protein 2-alphamelanoma growth stimulatory activity betaC-X-C motif chemokine 2GRO2 oncogeneMGSA betaMIP2-alphachemokine (C-X-C motif) ligand 2gro-betagrowth-regulated protein betamacrophage inflammatory protein 2-alphamelanoma growth stimulatory activity beta
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000296031, ENST00000508487, 
ENST00000508487, ENST00000296031, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: CXCL2 [Title/Abstract] AND CXCL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCXCL2(74962827)-CXCL2(74962784), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCXCL2

GO:0002237

response to molecule of bacterial origin

19912257

TgeneCXCL2

GO:0002237

response to molecule of bacterial origin

19912257



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for CXCL2-CXCL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CXCL2-CXCL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CXCL2-CXCL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:74962827/:74962784)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CXCL2-CXCL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CXCL2-CXCL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CXCL2-CXCL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CXCL2-CXCL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCXCL2C0003873Rheumatoid Arthritis1CTD_human
HgeneCXCL2C0005974Bone Resorption1CTD_human
HgeneCXCL2C0006142Malignant neoplasm of breast1CTD_human
HgeneCXCL2C0008370Cholestasis1CTD_human
HgeneCXCL2C0014859Esophageal Neoplasms1CTD_human
HgeneCXCL2C0018801Heart failure1CTD_human
HgeneCXCL2C0018802Congestive heart failure1CTD_human
HgeneCXCL2C0020538Hypertensive disease1CTD_human
HgeneCXCL2C0021368Inflammation1CTD_human
HgeneCXCL2C0023212Left-Sided Heart Failure1CTD_human
HgeneCXCL2C0024117Chronic Obstructive Airway Disease1CTD_human
HgeneCXCL2C0029408Degenerative polyarthritis1CTD_human
HgeneCXCL2C0034069Pulmonary Fibrosis1CTD_human
HgeneCXCL2C0035126Reperfusion Injury1CTD_human
HgeneCXCL2C0036982Shock, Hemorrhagic1CTD_human
HgeneCXCL2C0037274Dermatologic disorders1CTD_human
HgeneCXCL2C0086743Osteoarthrosis Deformans1CTD_human
HgeneCXCL2C0151744Myocardial Ischemia1CTD_human
HgeneCXCL2C0162820Dermatitis, Allergic Contact1CTD_human
HgeneCXCL2C0235527Heart Failure, Right-Sided1CTD_human
HgeneCXCL2C0238281Middle Cerebral Artery Syndrome1CTD_human
HgeneCXCL2C0242488Acute Lung Injury1CTD_human
HgeneCXCL2C0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneCXCL2C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneCXCL2C0311375Arsenic Poisoning1CTD_human
HgeneCXCL2C0546837Malignant neoplasm of esophagus1CTD_human
HgeneCXCL2C0678222Breast Carcinoma1CTD_human
HgeneCXCL2C0740376Middle Cerebral Artery Thrombosis1CTD_human
HgeneCXCL2C0740391Middle Cerebral Artery Occlusion1CTD_human
HgeneCXCL2C0740392Infarction, Middle Cerebral Artery1CTD_human
HgeneCXCL2C0751845Middle Cerebral Artery Embolus1CTD_human
HgeneCXCL2C0751846Left Middle Cerebral Artery Infarction1CTD_human
HgeneCXCL2C0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
HgeneCXCL2C0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
HgeneCXCL2C0751849Right Middle Cerebral Artery Infarction1CTD_human
HgeneCXCL2C0751851Arsenic Encephalopathy1CTD_human
HgeneCXCL2C0751852Arsenic Induced Polyneuropathy1CTD_human
HgeneCXCL2C1257931Mammary Neoplasms, Human1CTD_human
HgeneCXCL2C1458155Mammary Neoplasms1CTD_human
HgeneCXCL2C1527303Chronic Airflow Obstruction1CTD_human
HgeneCXCL2C1959583Myocardial Failure1CTD_human
HgeneCXCL2C1961112Heart Decompensation1CTD_human
HgeneCXCL2C4704874Mammary Carcinoma, Human1CTD_human
HgeneCXCL2C4721507Alveolitis, Fibrosing1CTD_human
TgeneC0003873Rheumatoid Arthritis1CTD_human
TgeneC0005974Bone Resorption1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0008370Cholestasis1CTD_human
TgeneC0014859Esophageal Neoplasms1CTD_human
TgeneC0018801Heart failure1CTD_human
TgeneC0018802Congestive heart failure1CTD_human
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0021368Inflammation1CTD_human
TgeneC0023212Left-Sided Heart Failure1CTD_human
TgeneC0024117Chronic Obstructive Airway Disease1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0034069Pulmonary Fibrosis1CTD_human
TgeneC0035126Reperfusion Injury1CTD_human
TgeneC0036982Shock, Hemorrhagic1CTD_human
TgeneC0037274Dermatologic disorders1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0151744Myocardial Ischemia1CTD_human
TgeneC0162820Dermatitis, Allergic Contact1CTD_human
TgeneC0235527Heart Failure, Right-Sided1CTD_human
TgeneC0238281Middle Cerebral Artery Syndrome1CTD_human
TgeneC0242488Acute Lung Injury1CTD_human
TgeneC0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneC0311375Arsenic Poisoning1CTD_human
TgeneC0546837Malignant neoplasm of esophagus1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0740376Middle Cerebral Artery Thrombosis1CTD_human
TgeneC0740391Middle Cerebral Artery Occlusion1CTD_human
TgeneC0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneC0751845Middle Cerebral Artery Embolus1CTD_human
TgeneC0751846Left Middle Cerebral Artery Infarction1CTD_human
TgeneC0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
TgeneC0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
TgeneC0751849Right Middle Cerebral Artery Infarction1CTD_human
TgeneC0751851Arsenic Encephalopathy1CTD_human
TgeneC0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1527303Chronic Airflow Obstruction1CTD_human
TgeneC1959583Myocardial Failure1CTD_human
TgeneC1961112Heart Decompensation1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4721507Alveolitis, Fibrosing1CTD_human