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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GSTM4-GSTM4 (FusionGDB2 ID:HG2948TG2948)

Fusion Gene Summary for GSTM4-GSTM4

check button Fusion gene summary
Fusion gene informationFusion gene name: GSTM4-GSTM4
Fusion gene ID: hg2948tg2948
HgeneTgene
Gene symbol

GSTM4

GSTM4

Gene ID

2948

2948

Gene nameglutathione S-transferase mu 4glutathione S-transferase mu 4
SynonymsGSTM4-4|GTM4GSTM4-4|GTM4
Cytomap('GSTM4')('GSTM4')

1p13.3

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionglutathione S-transferase Mu 4GST class-mu 4GST-Mu2GTS-Mu2S-(hydroxyalkyl)glutathione lyase M4glutathione S-alkyltransferase M4glutathione S-aralkyltransferase M4glutathione S-aryltransferase M4glutathione S-transferase M4testis tissue sperm-bindglutathione S-transferase Mu 4GST class-mu 4GST-Mu2GTS-Mu2S-(hydroxyalkyl)glutathione lyase M4glutathione S-alkyltransferase M4glutathione S-aralkyltransferase M4glutathione S-aryltransferase M4glutathione S-transferase M4testis tissue sperm-bind
Modification date2020032720200327
UniProtAcc

Q03013

Q03013

Ensembl transtripts involved in fusion geneENST00000495742, ENST00000326729, 
ENST00000369833, ENST00000369836, 
ENST00000336075, 
ENST00000495742, 
ENST00000326729, ENST00000336075, 
ENST00000369833, ENST00000369836, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GSTM4 [Title/Abstract] AND GSTM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGSTM4(110200443)-GSTM4(110199002), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSTM4

GO:0006749

glutathione metabolic process

8373352

HgeneGSTM4

GO:0042178

xenobiotic catabolic process

8373352

TgeneGSTM4

GO:0006749

glutathione metabolic process

8373352

TgeneGSTM4

GO:0042178

xenobiotic catabolic process

8373352



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for GSTM4-GSTM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GSTM4-GSTM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for GSTM4-GSTM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:110200443/:110199002)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSTM4

Q03013

GSTM4

Q03013

FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). {ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:8203914, ECO:0000269|PubMed:8373352}.FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). {ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:8203914, ECO:0000269|PubMed:8373352}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GSTM4-GSTM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GSTM4-GSTM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GSTM4-GSTM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSTM4Q03013DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical
TgeneGSTM4Q03013DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical

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Related Diseases for GSTM4-GSTM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSTM4C0019193Hepatitis, Toxic1CTD_human
HgeneGSTM4C0270715Degenerative Diseases, Central Nervous System1CTD_human
HgeneGSTM4C0524851Neurodegenerative Disorders1CTD_human
HgeneGSTM4C0751733Degenerative Diseases, Spinal Cord1CTD_human
HgeneGSTM4C0860207Drug-Induced Liver Disease1CTD_human
HgeneGSTM4C1262760Hepatitis, Drug-Induced1CTD_human
HgeneGSTM4C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneGSTM4C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneGSTM4C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneC0524851Neurodegenerative Disorders1CTD_human
TgeneC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human