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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GTF2I-FLAD1 (FusionGDB2 ID:HG2969TG80308)

Fusion Gene Summary for GTF2I-FLAD1

Fusion gene summary

Fusion gene information	Fusion gene name: GTF2I-FLAD1
	Fusion gene ID: hg2969tg80308
		Hgene	Tgene
	Gene symbol	GTF2I	FLAD1
	Gene ID	2969	80308
	Gene name	general transcription factor IIi	flavin adenine dinucleotide synthetase 1
	Synonyms	BAP135\|BTKAP1\|DIWS\|GTFII-I\|IB291\|SPIN\|TFII-I\|WBS\|WBSCR6	FAD1\|FADS\|LSMFLAD\|PP591
	Cytomap	('GTF2I')('FLAD1') 7q11.23	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	general transcription factor II-IBTK-associated protein, 135kDBruton tyrosine kinase-associated protein 135SRF-Phox1-interacting proteinWilliams-Beuren syndrome chromosome region 6	FAD synthaseFAD pyrophosphorylaseFAD-synthetaseFMN adenylyltransferaseFad1, flavin adenine dinucleotide synthetase, homolog
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000324896, ENST00000346152, ENST00000353920, ENST00000416070, ENST00000443166, ENST00000438130,
Fusion gene scores	* DoF score	13 X 15 X 8=1560	9 X 9 X 6=486
	# samples	14	10
	** MAII score	log2(14/1560*10)=-3.47804729680464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/486*10)=-2.28095631383106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GTF2I [Title/Abstract] AND FLAD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GTF2I(74072394)-FLAD1(154960581), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GTF2I	GO:0016525	negative regulation of angiogenesis	19242469

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ACC	TCGA-OR-A5J7-01A	GTF2I	chr7	74072394	-	FLAD1	chr1	154960581	+
ChimerDB4	ACC	TCGA-OR-A5J7-01A	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
ChimerDB4	ACC	TCGA-OR-A5J7-01A	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+

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Fusion Gene ORF analysis for GTF2I-FLAD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000324896	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000324896	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000324896	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000324896	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000324896	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000346152	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000346152	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000346152	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000346152	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000346152	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000353920	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000353920	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000353920	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000353920	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000353920	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000416070	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000416070	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000416070	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000416070	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000416070	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000443166	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000443166	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000443166	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000443166	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3CDS	ENST00000443166	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3UTR	ENST00000324896	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3UTR	ENST00000324896	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3UTR	ENST00000346152	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3UTR	ENST00000346152	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3UTR	ENST00000353920	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3UTR	ENST00000353920	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3UTR	ENST00000416070	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3UTR	ENST00000416070	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3UTR	ENST00000443166	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-3UTR	ENST00000443166	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-5UTR	ENST00000324896	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-5UTR	ENST00000346152	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-5UTR	ENST00000353920	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-5UTR	ENST00000416070	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-5UTR	ENST00000443166	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-intron	ENST00000324896	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000324896	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000324896	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000324896	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-intron	ENST00000324896	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000324896	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000324896	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000324896	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000324896	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000324896	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000346152	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000346152	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000346152	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000346152	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-intron	ENST00000346152	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000346152	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000346152	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000346152	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000346152	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000346152	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000353920	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000353920	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000353920	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000353920	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-intron	ENST00000353920	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000353920	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000353920	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000353920	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000353920	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000353920	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000416070	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000416070	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000416070	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000416070	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-intron	ENST00000416070	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000416070	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000416070	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000416070	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000416070	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000416070	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000443166	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000443166	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000443166	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000443166	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
5UTR-intron	ENST00000443166	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000443166	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000443166	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000443166	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000443166	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
5UTR-intron	ENST00000443166	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
intron-3CDS	ENST00000438130	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
intron-3CDS	ENST00000438130	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
intron-3CDS	ENST00000438130	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
intron-3CDS	ENST00000438130	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
intron-3CDS	ENST00000438130	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
intron-3UTR	ENST00000438130	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
intron-3UTR	ENST00000438130	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
intron-5UTR	ENST00000438130	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
intron-intron	ENST00000438130	ENST00000292180	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
intron-intron	ENST00000438130	ENST00000295530	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
intron-intron	ENST00000438130	ENST00000315144	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
intron-intron	ENST00000438130	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154960581	+
intron-intron	ENST00000438130	ENST00000368428	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
intron-intron	ENST00000438130	ENST00000368431	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
intron-intron	ENST00000438130	ENST00000368432	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
intron-intron	ENST00000438130	ENST00000368433	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
intron-intron	ENST00000438130	ENST00000405236	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+
intron-intron	ENST00000438130	ENST00000487371	GTF2I	chr7	74072394	+	FLAD1	chr1	154965041	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for GTF2I-FLAD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GTF2I	chr7	74072394	+	FLAD1	chr1	154965040	+	5.93E-05	0.99994075
GTF2I	chr7	74072394	+	FLAD1	chr1	154960580	+	2.99E-05	0.9999701
GTF2I	chr7	74072394	+	FLAD1	chr1	154965040	+	5.93E-05	0.99994075
GTF2I	chr7	74072394	+	FLAD1	chr1	154960580	+	2.99E-05	0.9999701

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GTF2I-FLAD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:74072394/:154960581)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for GTF2I-FLAD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GTF2I-FLAD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GTF2I-FLAD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GTF2I-FLAD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	GTF2I	C0004238	Atrial Fibrillation	2	CTD_human
Hgene	GTF2I	C0175702	Williams Syndrome	2	CTD_human
Hgene	GTF2I	C0235480	Paroxysmal atrial fibrillation	2	CTD_human
Hgene	GTF2I	C2585653	Persistent atrial fibrillation	2	CTD_human
Hgene	GTF2I	C3468561	familial atrial fibrillation	2	CTD_human
Hgene	GTF2I	C0023467	Leukemia, Myelocytic, Acute	1	CTD_human
Hgene	GTF2I	C0026998	Acute Myeloid Leukemia, M1	1	CTD_human
Hgene	GTF2I	C0086981	Sicca Syndrome	1	CTD_human
Hgene	GTF2I	C1266101	Thymic epithelial tumor	1	CTD_human
Hgene	GTF2I	C1510586	Autism Spectrum Disorders	1	CTD_human
Hgene	GTF2I	C1527336	Sjogren's Syndrome	1	CTD_human
Hgene	GTF2I	C1879321	Acute Myeloid Leukemia (AML-M2)	1	CTD_human
Tgene		C4310822	LIPID STORAGE MYOPATHY DUE TO FLAVIN ADENINE DINUCLEOTIDE SYNTHETASE DEFICIENCY	4	CLINGEN;GENOMICS_ENGLAND;UNIPROT

Fusion Gene Studies in Kim Lab

Fusion gene:GTF2I-FLAD1 (FusionGDB2 ID:HG2969TG80308)

Fusion Gene Summary for GTF2I-FLAD1

Fusion Gene ORF analysis for GTF2I-FLAD1

Fusion Genomic Features for GTF2I-FLAD1

Fusion Protein Features for GTF2I-FLAD1

Fusion Gene Sequence for GTF2I-FLAD1

Fusion Gene PPI Analysis for GTF2I-FLAD1

Related Drugs for GTF2I-FLAD1

Related Diseases for GTF2I-FLAD1

Fusion Gene Studies
in Kim Lab