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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BLNK-ZNF536 (FusionGDB2 ID:HG29760TG9745)

Fusion Gene Summary for BLNK-ZNF536

check button Fusion gene summary
Fusion gene informationFusion gene name: BLNK-ZNF536
Fusion gene ID: hg29760tg9745
HgeneTgene
Gene symbol

BLNK

ZNF536

Gene ID

29760

9745

Gene nameB cell linkerzinc finger protein 536
SynonymsAGM4|BASH|BLNK-S|LY57|SLP-65|SLP65|bca-
Cytomap('BLNK')('ZNF536')

10q24.1

19q12

Type of geneprotein-codingprotein-coding
DescriptionB-cell linker proteinB cell adaptor containing SH2 domainB-cell activationB-cell adapter containing a SH2 domain proteinB-cell adapter containing a Src homology 2 domain proteinSrc homology 2 domain-containing leukocyte protein of 65 kDaSrc homologyzinc finger protein 536
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000224337, ENST00000371176, 
ENST00000413476, ENST00000427367, 
ENST00000495266, 
Fusion gene scores* DoF score7 X 6 X 6=25221 X 13 X 13=3549
# samples 725
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3549*10)=-3.82741257439886
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BLNK [Title/Abstract] AND ZNF536 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBLNK(98002491)-ZNF536(31025754), # samples:3
Anticipated loss of major functional domain due to fusion event.BLNK-ZNF536 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BLNK-ZNF536 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BLNK-ZNF536 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BLNK-ZNF536 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBLNK

GO:0035556

intracellular signal transduction

9341187

TgeneZNF536

GO:0000122

negative regulation of transcription by RNA polymerase II

19398580


check buttonFusion gene breakpoints across BLNK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZNF536 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08I-01ABLNKchr10

98002491

-ZNF536chr19

31025754

+


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Fusion Gene ORF analysis for BLNK-ZNF536

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000224337ENST00000590564BLNKchr10

98002491

-ZNF536chr19

31025754

+
5CDS-intronENST00000371176ENST00000590564BLNKchr10

98002491

-ZNF536chr19

31025754

+
5CDS-intronENST00000413476ENST00000590564BLNKchr10

98002491

-ZNF536chr19

31025754

+
5CDS-intronENST00000427367ENST00000590564BLNKchr10

98002491

-ZNF536chr19

31025754

+
5CDS-intronENST00000495266ENST00000590564BLNKchr10

98002491

-ZNF536chr19

31025754

+
In-frameENST00000224337ENST00000355537BLNKchr10

98002491

-ZNF536chr19

31025754

+
In-frameENST00000371176ENST00000355537BLNKchr10

98002491

-ZNF536chr19

31025754

+
In-frameENST00000413476ENST00000355537BLNKchr10

98002491

-ZNF536chr19

31025754

+
In-frameENST00000427367ENST00000355537BLNKchr10

98002491

-ZNF536chr19

31025754

+
In-frameENST00000495266ENST00000355537BLNKchr10

98002491

-ZNF536chr19

31025754

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000224337BLNKchr1098002491-ENST00000355537ZNF536chr1931025754+29333051032037644
ENST00000371176BLNKchr1098002491-ENST00000355537ZNF536chr1931025754+29333051032037644
ENST00000427367BLNKchr1098002491-ENST00000355537ZNF536chr1931025754+29693411392073644
ENST00000413476BLNKchr1098002491-ENST00000355537ZNF536chr1931025754+29693411392073644
ENST00000495266BLNKchr1098002491-ENST00000355537ZNF536chr1931025754+279116301895631

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000224337ENST00000355537BLNKchr1098002491-ZNF536chr1931025754+0.0005179950.999482
ENST00000371176ENST00000355537BLNKchr1098002491-ZNF536chr1931025754+0.0005179950.999482
ENST00000427367ENST00000355537BLNKchr1098002491-ZNF536chr1931025754+0.0005298250.9994702
ENST00000413476ENST00000355537BLNKchr1098002491-ZNF536chr1931025754+0.0005298250.9994702
ENST00000495266ENST00000355537BLNKchr1098002491-ZNF536chr1931025754+0.000491880.99950814

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Fusion Genomic Features for BLNK-ZNF536


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BLNKchr1098002490-ZNF536chr1931025753+3.49E-050.9999651
BLNKchr1098002490-ZNF536chr1931025753+3.49E-050.9999651

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BLNK-ZNF536


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:98002491/chr19:31025754)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF536chr10:98002491chr19:31025754ENST0000035553715751_7737231301.0Zinc fingerC2H2-type 8
TgeneZNF536chr10:98002491chr19:31025754ENST0000035553715779_8017231301.0Zinc fingerC2H2-type 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBLNKchr10:98002491chr19:31025754ENST00000224337-31798_26054457.0Compositional biasNote=Pro-rich
HgeneBLNKchr10:98002491chr19:31025754ENST00000371176-31698_26054434.0Compositional biasNote=Pro-rich
HgeneBLNKchr10:98002491chr19:31025754ENST00000413476-31698_26054405.0Compositional biasNote=Pro-rich
HgeneBLNKchr10:98002491chr19:31025754ENST00000224337-317346_45354457.0DomainSH2
HgeneBLNKchr10:98002491chr19:31025754ENST00000371176-316346_45354434.0DomainSH2
HgeneBLNKchr10:98002491chr19:31025754ENST00000413476-316346_45354405.0DomainSH2
TgeneZNF536chr10:98002491chr19:31025754ENST0000035553715130_1527231301.0Zinc fingerC2H2-type 1
TgeneZNF536chr10:98002491chr19:31025754ENST0000035553715158_1807231301.0Zinc fingerC2H2-type 2
TgeneZNF536chr10:98002491chr19:31025754ENST0000035553715274_2977231301.0Zinc fingerC2H2-type 3
TgeneZNF536chr10:98002491chr19:31025754ENST0000035553715300_3237231301.0Zinc fingerC2H2-type 4
TgeneZNF536chr10:98002491chr19:31025754ENST0000035553715345_3677231301.0Zinc fingerC2H2-type 5
TgeneZNF536chr10:98002491chr19:31025754ENST0000035553715373_3957231301.0Zinc fingerC2H2-type 6
TgeneZNF536chr10:98002491chr19:31025754ENST0000035553715631_6537231301.0Zinc fingerC2H2-type 7


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Fusion Gene Sequence for BLNK-ZNF536


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9815_9815_1_BLNK-ZNF536_BLNK_chr10_98002491_ENST00000224337_ZNF536_chr19_31025754_ENST00000355537_length(transcript)=2933nt_BP=305nt
GCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGAGGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACT
GCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAATGGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCA
GAAGTTGAGGCAGCTTCAAAAGATGGTCCATGATATTAAAAACAATGAAGGTGGAATAATGAATAAAATCAAAAAGCTAAAAGTCAAAGC
ACCTCCAAGTGTTCCTCGAAGGGACTACGCTTCAGACATTGGCGAGGAGGCTGGGAGATCTGCCGGCGTCCAGCAACCAGCGCTGCTTCG
CGACAGAAGCCTGGGCTCGGCCATGAAGGACTGCCCGTACTGTGGGAAAACTTTCCGGACATCCCATCACCTTAAGGTGCACCTGAGGAT
ACACACAGGTGAGAAACCCTACAAGTGTCCGCACTGTGACTATGCCGGCACGCAGTCAGCATCCTTAAAATACCACTTAGAGCGACACCA
TCGGGAGCGGCAGAACGGGGCTGGGCCGCTGTCTGGGCAACCCCCAAATCAAGACCACAAGGATGAGATGTCAAGCAAAGCTTCTCTGTT
CATCAGGCCAGACATCCTGAGGGGGGCCTTCAAGGGTCTCCCTGGAATCGACTTCAGAGGAGGCCCTGCATCTCAGCAGTGGACATCAGG
GGTTCTCTCCTCTGGAGATCACTCGGGGCAGGCCACGGGCATGTCTTCGGAGGTCCCCTCAGATGCTCTGAAAGGCACTGACCTTCCTTC
CAAAAGCACCCACTTCTCTGAGATCGGAAGAGCTTATCAAAGCATTGTGAGCAACGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCAT
GGACAGTTTTGTCCTCAGTTCCTTGAAGAAGGAGAAGGACATGAAGGACAAAGCCCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGT
GGATGGTGGTGAGGAGAAACCCAGTGGCAAGTCCTCCCAGAGGAAGTCCGAGAAATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCC
AGATGCCGCCTCCCTCCCGGGCTCCTCGGTAACTGTGCAGGACAGCATTGCATGGCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTC
CATGGAGCTCATGGCCCTTCATCTCCAGGCCAACCACCTGGGCAAAGCGAAACGCAAAGATAACACCATCGGGGTCACAGTCAACTGCAA
AGACCAAGCCCGGGAGGCGAGTAAGATGGCCCTGCTGCCCTCGTTACAATCAAACAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCT
AGACTCTGCTTCTGAGAAGATGGCCCAAGGTCAGCTCAAGGAGACTCTGGGAGAGCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCC
TGCATTTTGTAACTTCCCATCAGACTTCTACAAGCAGTTTGGTGTTTACCCAGGCATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAA
CAAGGAGCCTGATGGAAAGGCCCACTCTGAAGAGGATGTCCCCATCCTGATCCCCGAAACCACGAGTAAGAACACTACTGATGACCTCTC
TGACATTGCCTCCTCAGAGGACATGGACTCCTCCAAGGGGGAGAACAACGATGAAGAGGATGTTGAAACCGAACCGGAAATGATGACCAA
GCCACTGTCTGCCCTCAGCAAAGACAGCAGCAGCGATGGCGGGGACAGCCTGCAGCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGT
CTCACCTTTATCCCAAGCACCGGAGAAGCAGTGGCACAGCCAGGGTCTTCTCCAAGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGA
GCGGGGGCCCCAGAGCCTGGACAAGCCGATGAACATGCTGTCGGTCCTCAGGGCCTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACT
TGCAAGTAGCACAGCAAATTCTGGATGTATCAAGAGGCCAGACTTGTGTGGTAAGTGACACTCCCTGTCCTAGTCGGTCTATCTGGACTT
GCCCTTGTCTGTTCGTGGTCCTCGGTGGTTATCTGCAGCTTGTTAATCGTGTAAAGTCAAGAGAAGAATGTATACACATATGTGTGTTGA
ATAATTACTATTGGCATAGGTATGTGTATACACACGGTGCACCAATCTACAGTATATATAGCAGAGAATCAGAGGCTAAAAATATTACCC
CATATGTTCCAGTATTAGTCATGGATTGCAAAGGCTTAGTAACTTGAGCAGGAGAGAAAACTCCCTCAAAGTCATAAATCCTGAGTGACA
ACTGCTGCTGGATGACAGATCCCTTCACCTGTGGACAACCTGGCTGGGGGTGGGGGGCTGTTCCACCAGCTCACCTGAGCATGTAGAGGT
GGGTCCTGCAGTGGTCTCGTGGGTATTACTGCTTGTGTCTGATTGTCCTGTATTTTGTAACACTTTAGAAGAATACAGAAAAGTGCAGTA
ATTCTCTTTCTCCATAGTATTTAAGCAGAAATATTGCTAGTTTAATATTGTGTCAGGTCGTCCTATTAACCAGGAGCAGATGACAGTAAA
ATTTCAGTGAATAGCACCTTGACATCTACAACTTAAAAATGGTGATTGAAGCAAAATATGTAAACTTGTACGGGGTGATCGTGTGCTTTG
GAACAGAGTATTGTTGAAGTAATTAGAAGATATATTAAGGTGTTCCTGGTAATGAAGGCATGTAAGTTATAATAATTGTAGCTTTCTGAA
TAAGTGTCAAACTATATCTTTAAGTGTGCTGTATGCTGAGTTACAAGTTAGGTCATTTATGAATGGAATGTAAAATAATACTAAAAATGC

>9815_9815_1_BLNK-ZNF536_BLNK_chr10_98002491_ENST00000224337_ZNF536_chr19_31025754_ENST00000355537_length(amino acids)=644AA_BP=65
MDSYSCLLQLPNRMDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASDIGEEAGRSAGVQQPALLRDRSL
GSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPD
ILRGAFKGLPGIDFRGGPASQQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEIGRAYQSIVSNGVNFQGSLQAFMDSFV
LSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELM
ALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWTGHVDPAFCN
FPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSA
LSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLAAFNGLASST

--------------------------------------------------------------
>9815_9815_2_BLNK-ZNF536_BLNK_chr10_98002491_ENST00000371176_ZNF536_chr19_31025754_ENST00000355537_length(transcript)=2933nt_BP=305nt
GCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGAGGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACT
GCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAATGGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCA
GAAGTTGAGGCAGCTTCAAAAGATGGTCCATGATATTAAAAACAATGAAGGTGGAATAATGAATAAAATCAAAAAGCTAAAAGTCAAAGC
ACCTCCAAGTGTTCCTCGAAGGGACTACGCTTCAGACATTGGCGAGGAGGCTGGGAGATCTGCCGGCGTCCAGCAACCAGCGCTGCTTCG
CGACAGAAGCCTGGGCTCGGCCATGAAGGACTGCCCGTACTGTGGGAAAACTTTCCGGACATCCCATCACCTTAAGGTGCACCTGAGGAT
ACACACAGGTGAGAAACCCTACAAGTGTCCGCACTGTGACTATGCCGGCACGCAGTCAGCATCCTTAAAATACCACTTAGAGCGACACCA
TCGGGAGCGGCAGAACGGGGCTGGGCCGCTGTCTGGGCAACCCCCAAATCAAGACCACAAGGATGAGATGTCAAGCAAAGCTTCTCTGTT
CATCAGGCCAGACATCCTGAGGGGGGCCTTCAAGGGTCTCCCTGGAATCGACTTCAGAGGAGGCCCTGCATCTCAGCAGTGGACATCAGG
GGTTCTCTCCTCTGGAGATCACTCGGGGCAGGCCACGGGCATGTCTTCGGAGGTCCCCTCAGATGCTCTGAAAGGCACTGACCTTCCTTC
CAAAAGCACCCACTTCTCTGAGATCGGAAGAGCTTATCAAAGCATTGTGAGCAACGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCAT
GGACAGTTTTGTCCTCAGTTCCTTGAAGAAGGAGAAGGACATGAAGGACAAAGCCCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGT
GGATGGTGGTGAGGAGAAACCCAGTGGCAAGTCCTCCCAGAGGAAGTCCGAGAAATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCC
AGATGCCGCCTCCCTCCCGGGCTCCTCGGTAACTGTGCAGGACAGCATTGCATGGCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTC
CATGGAGCTCATGGCCCTTCATCTCCAGGCCAACCACCTGGGCAAAGCGAAACGCAAAGATAACACCATCGGGGTCACAGTCAACTGCAA
AGACCAAGCCCGGGAGGCGAGTAAGATGGCCCTGCTGCCCTCGTTACAATCAAACAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCT
AGACTCTGCTTCTGAGAAGATGGCCCAAGGTCAGCTCAAGGAGACTCTGGGAGAGCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCC
TGCATTTTGTAACTTCCCATCAGACTTCTACAAGCAGTTTGGTGTTTACCCAGGCATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAA
CAAGGAGCCTGATGGAAAGGCCCACTCTGAAGAGGATGTCCCCATCCTGATCCCCGAAACCACGAGTAAGAACACTACTGATGACCTCTC
TGACATTGCCTCCTCAGAGGACATGGACTCCTCCAAGGGGGAGAACAACGATGAAGAGGATGTTGAAACCGAACCGGAAATGATGACCAA
GCCACTGTCTGCCCTCAGCAAAGACAGCAGCAGCGATGGCGGGGACAGCCTGCAGCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGT
CTCACCTTTATCCCAAGCACCGGAGAAGCAGTGGCACAGCCAGGGTCTTCTCCAAGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGA
GCGGGGGCCCCAGAGCCTGGACAAGCCGATGAACATGCTGTCGGTCCTCAGGGCCTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACT
TGCAAGTAGCACAGCAAATTCTGGATGTATCAAGAGGCCAGACTTGTGTGGTAAGTGACACTCCCTGTCCTAGTCGGTCTATCTGGACTT
GCCCTTGTCTGTTCGTGGTCCTCGGTGGTTATCTGCAGCTTGTTAATCGTGTAAAGTCAAGAGAAGAATGTATACACATATGTGTGTTGA
ATAATTACTATTGGCATAGGTATGTGTATACACACGGTGCACCAATCTACAGTATATATAGCAGAGAATCAGAGGCTAAAAATATTACCC
CATATGTTCCAGTATTAGTCATGGATTGCAAAGGCTTAGTAACTTGAGCAGGAGAGAAAACTCCCTCAAAGTCATAAATCCTGAGTGACA
ACTGCTGCTGGATGACAGATCCCTTCACCTGTGGACAACCTGGCTGGGGGTGGGGGGCTGTTCCACCAGCTCACCTGAGCATGTAGAGGT
GGGTCCTGCAGTGGTCTCGTGGGTATTACTGCTTGTGTCTGATTGTCCTGTATTTTGTAACACTTTAGAAGAATACAGAAAAGTGCAGTA
ATTCTCTTTCTCCATAGTATTTAAGCAGAAATATTGCTAGTTTAATATTGTGTCAGGTCGTCCTATTAACCAGGAGCAGATGACAGTAAA
ATTTCAGTGAATAGCACCTTGACATCTACAACTTAAAAATGGTGATTGAAGCAAAATATGTAAACTTGTACGGGGTGATCGTGTGCTTTG
GAACAGAGTATTGTTGAAGTAATTAGAAGATATATTAAGGTGTTCCTGGTAATGAAGGCATGTAAGTTATAATAATTGTAGCTTTCTGAA
TAAGTGTCAAACTATATCTTTAAGTGTGCTGTATGCTGAGTTACAAGTTAGGTCATTTATGAATGGAATGTAAAATAATACTAAAAATGC

>9815_9815_2_BLNK-ZNF536_BLNK_chr10_98002491_ENST00000371176_ZNF536_chr19_31025754_ENST00000355537_length(amino acids)=644AA_BP=65
MDSYSCLLQLPNRMDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASDIGEEAGRSAGVQQPALLRDRSL
GSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPD
ILRGAFKGLPGIDFRGGPASQQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEIGRAYQSIVSNGVNFQGSLQAFMDSFV
LSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELM
ALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWTGHVDPAFCN
FPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSA
LSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLAAFNGLASST

--------------------------------------------------------------
>9815_9815_3_BLNK-ZNF536_BLNK_chr10_98002491_ENST00000413476_ZNF536_chr19_31025754_ENST00000355537_length(transcript)=2969nt_BP=341nt
AAGTTTTACTTCTCCCTAGAGCAGGGGTGTTTGCCAGCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGA
GGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACTGCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAAT
GGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCAGAAGTTGAGGCAGCTTCAAAAGATGGTCCATGATATTAAAAACAATGAAGGTGG
AATAATGAATAAAATCAAAAAGCTAAAAGTCAAAGCACCTCCAAGTGTTCCTCGAAGGGACTACGCTTCAGACATTGGCGAGGAGGCTGG
GAGATCTGCCGGCGTCCAGCAACCAGCGCTGCTTCGCGACAGAAGCCTGGGCTCGGCCATGAAGGACTGCCCGTACTGTGGGAAAACTTT
CCGGACATCCCATCACCTTAAGGTGCACCTGAGGATACACACAGGTGAGAAACCCTACAAGTGTCCGCACTGTGACTATGCCGGCACGCA
GTCAGCATCCTTAAAATACCACTTAGAGCGACACCATCGGGAGCGGCAGAACGGGGCTGGGCCGCTGTCTGGGCAACCCCCAAATCAAGA
CCACAAGGATGAGATGTCAAGCAAAGCTTCTCTGTTCATCAGGCCAGACATCCTGAGGGGGGCCTTCAAGGGTCTCCCTGGAATCGACTT
CAGAGGAGGCCCTGCATCTCAGCAGTGGACATCAGGGGTTCTCTCCTCTGGAGATCACTCGGGGCAGGCCACGGGCATGTCTTCGGAGGT
CCCCTCAGATGCTCTGAAAGGCACTGACCTTCCTTCCAAAAGCACCCACTTCTCTGAGATCGGAAGAGCTTATCAAAGCATTGTGAGCAA
CGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCATGGACAGTTTTGTCCTCAGTTCCTTGAAGAAGGAGAAGGACATGAAGGACAAAGC
CCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGTGGATGGTGGTGAGGAGAAACCCAGTGGCAAGTCCTCCCAGAGGAAGTCCGAGAA
ATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCCAGATGCCGCCTCCCTCCCGGGCTCCTCGGTAACTGTGCAGGACAGCATTGCATG
GCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTCCATGGAGCTCATGGCCCTTCATCTCCAGGCCAACCACCTGGGCAAAGCGAAACG
CAAAGATAACACCATCGGGGTCACAGTCAACTGCAAAGACCAAGCCCGGGAGGCGAGTAAGATGGCCCTGCTGCCCTCGTTACAATCAAA
CAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCTAGACTCTGCTTCTGAGAAGATGGCCCAAGGTCAGCTCAAGGAGACTCTGGGAGA
GCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCCTGCATTTTGTAACTTCCCATCAGACTTCTACAAGCAGTTTGGTGTTTACCCAGG
CATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAACAAGGAGCCTGATGGAAAGGCCCACTCTGAAGAGGATGTCCCCATCCTGATCCC
CGAAACCACGAGTAAGAACACTACTGATGACCTCTCTGACATTGCCTCCTCAGAGGACATGGACTCCTCCAAGGGGGAGAACAACGATGA
AGAGGATGTTGAAACCGAACCGGAAATGATGACCAAGCCACTGTCTGCCCTCAGCAAAGACAGCAGCAGCGATGGCGGGGACAGCCTGCA
GCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGTCTCACCTTTATCCCAAGCACCGGAGAAGCAGTGGCACAGCCAGGGTCTTCTCCA
AGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGAGCGGGGGCCCCAGAGCCTGGACAAGCCGATGAACATGCTGTCGGTCCTCAGGGC
CTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACTTGCAAGTAGCACAGCAAATTCTGGATGTATCAAGAGGCCAGACTTGTGTGGTAA
GTGACACTCCCTGTCCTAGTCGGTCTATCTGGACTTGCCCTTGTCTGTTCGTGGTCCTCGGTGGTTATCTGCAGCTTGTTAATCGTGTAA
AGTCAAGAGAAGAATGTATACACATATGTGTGTTGAATAATTACTATTGGCATAGGTATGTGTATACACACGGTGCACCAATCTACAGTA
TATATAGCAGAGAATCAGAGGCTAAAAATATTACCCCATATGTTCCAGTATTAGTCATGGATTGCAAAGGCTTAGTAACTTGAGCAGGAG
AGAAAACTCCCTCAAAGTCATAAATCCTGAGTGACAACTGCTGCTGGATGACAGATCCCTTCACCTGTGGACAACCTGGCTGGGGGTGGG
GGGCTGTTCCACCAGCTCACCTGAGCATGTAGAGGTGGGTCCTGCAGTGGTCTCGTGGGTATTACTGCTTGTGTCTGATTGTCCTGTATT
TTGTAACACTTTAGAAGAATACAGAAAAGTGCAGTAATTCTCTTTCTCCATAGTATTTAAGCAGAAATATTGCTAGTTTAATATTGTGTC
AGGTCGTCCTATTAACCAGGAGCAGATGACAGTAAAATTTCAGTGAATAGCACCTTGACATCTACAACTTAAAAATGGTGATTGAAGCAA
AATATGTAAACTTGTACGGGGTGATCGTGTGCTTTGGAACAGAGTATTGTTGAAGTAATTAGAAGATATATTAAGGTGTTCCTGGTAATG
AAGGCATGTAAGTTATAATAATTGTAGCTTTCTGAATAAGTGTCAAACTATATCTTTAAGTGTGCTGTATGCTGAGTTACAAGTTAGGTC

>9815_9815_3_BLNK-ZNF536_BLNK_chr10_98002491_ENST00000413476_ZNF536_chr19_31025754_ENST00000355537_length(amino acids)=644AA_BP=65
MDSYSCLLQLPNRMDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASDIGEEAGRSAGVQQPALLRDRSL
GSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPD
ILRGAFKGLPGIDFRGGPASQQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEIGRAYQSIVSNGVNFQGSLQAFMDSFV
LSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELM
ALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWTGHVDPAFCN
FPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSA
LSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLAAFNGLASST

--------------------------------------------------------------
>9815_9815_4_BLNK-ZNF536_BLNK_chr10_98002491_ENST00000427367_ZNF536_chr19_31025754_ENST00000355537_length(transcript)=2969nt_BP=341nt
AAGTTTTACTTCTCCCTAGAGCAGGGGTGTTTGCCAGCAGCCTGCACTCTCAGAAATCAGACTTGAGTGGCCGGAACCCTTGAGACCAGA
GGCTTACCATGCTGCTCCCTAGGAGGGCCAGGAACTGCTGACGTGACCACTGGACAGTTATTCGTGTCTCTTACAATTACCAAACAGAAT
GGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCAGAAGTTGAGGCAGCTTCAAAAGATGGTCCATGATATTAAAAACAATGAAGGTGG
AATAATGAATAAAATCAAAAAGCTAAAAGTCAAAGCACCTCCAAGTGTTCCTCGAAGGGACTACGCTTCAGACATTGGCGAGGAGGCTGG
GAGATCTGCCGGCGTCCAGCAACCAGCGCTGCTTCGCGACAGAAGCCTGGGCTCGGCCATGAAGGACTGCCCGTACTGTGGGAAAACTTT
CCGGACATCCCATCACCTTAAGGTGCACCTGAGGATACACACAGGTGAGAAACCCTACAAGTGTCCGCACTGTGACTATGCCGGCACGCA
GTCAGCATCCTTAAAATACCACTTAGAGCGACACCATCGGGAGCGGCAGAACGGGGCTGGGCCGCTGTCTGGGCAACCCCCAAATCAAGA
CCACAAGGATGAGATGTCAAGCAAAGCTTCTCTGTTCATCAGGCCAGACATCCTGAGGGGGGCCTTCAAGGGTCTCCCTGGAATCGACTT
CAGAGGAGGCCCTGCATCTCAGCAGTGGACATCAGGGGTTCTCTCCTCTGGAGATCACTCGGGGCAGGCCACGGGCATGTCTTCGGAGGT
CCCCTCAGATGCTCTGAAAGGCACTGACCTTCCTTCCAAAAGCACCCACTTCTCTGAGATCGGAAGAGCTTATCAAAGCATTGTGAGCAA
CGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCATGGACAGTTTTGTCCTCAGTTCCTTGAAGAAGGAGAAGGACATGAAGGACAAAGC
CCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGTGGATGGTGGTGAGGAGAAACCCAGTGGCAAGTCCTCCCAGAGGAAGTCCGAGAA
ATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCCAGATGCCGCCTCCCTCCCGGGCTCCTCGGTAACTGTGCAGGACAGCATTGCATG
GCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTCCATGGAGCTCATGGCCCTTCATCTCCAGGCCAACCACCTGGGCAAAGCGAAACG
CAAAGATAACACCATCGGGGTCACAGTCAACTGCAAAGACCAAGCCCGGGAGGCGAGTAAGATGGCCCTGCTGCCCTCGTTACAATCAAA
CAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCTAGACTCTGCTTCTGAGAAGATGGCCCAAGGTCAGCTCAAGGAGACTCTGGGAGA
GCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCCTGCATTTTGTAACTTCCCATCAGACTTCTACAAGCAGTTTGGTGTTTACCCAGG
CATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAACAAGGAGCCTGATGGAAAGGCCCACTCTGAAGAGGATGTCCCCATCCTGATCCC
CGAAACCACGAGTAAGAACACTACTGATGACCTCTCTGACATTGCCTCCTCAGAGGACATGGACTCCTCCAAGGGGGAGAACAACGATGA
AGAGGATGTTGAAACCGAACCGGAAATGATGACCAAGCCACTGTCTGCCCTCAGCAAAGACAGCAGCAGCGATGGCGGGGACAGCCTGCA
GCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGTCTCACCTTTATCCCAAGCACCGGAGAAGCAGTGGCACAGCCAGGGTCTTCTCCA
AGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGAGCGGGGGCCCCAGAGCCTGGACAAGCCGATGAACATGCTGTCGGTCCTCAGGGC
CTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACTTGCAAGTAGCACAGCAAATTCTGGATGTATCAAGAGGCCAGACTTGTGTGGTAA
GTGACACTCCCTGTCCTAGTCGGTCTATCTGGACTTGCCCTTGTCTGTTCGTGGTCCTCGGTGGTTATCTGCAGCTTGTTAATCGTGTAA
AGTCAAGAGAAGAATGTATACACATATGTGTGTTGAATAATTACTATTGGCATAGGTATGTGTATACACACGGTGCACCAATCTACAGTA
TATATAGCAGAGAATCAGAGGCTAAAAATATTACCCCATATGTTCCAGTATTAGTCATGGATTGCAAAGGCTTAGTAACTTGAGCAGGAG
AGAAAACTCCCTCAAAGTCATAAATCCTGAGTGACAACTGCTGCTGGATGACAGATCCCTTCACCTGTGGACAACCTGGCTGGGGGTGGG
GGGCTGTTCCACCAGCTCACCTGAGCATGTAGAGGTGGGTCCTGCAGTGGTCTCGTGGGTATTACTGCTTGTGTCTGATTGTCCTGTATT
TTGTAACACTTTAGAAGAATACAGAAAAGTGCAGTAATTCTCTTTCTCCATAGTATTTAAGCAGAAATATTGCTAGTTTAATATTGTGTC
AGGTCGTCCTATTAACCAGGAGCAGATGACAGTAAAATTTCAGTGAATAGCACCTTGACATCTACAACTTAAAAATGGTGATTGAAGCAA
AATATGTAAACTTGTACGGGGTGATCGTGTGCTTTGGAACAGAGTATTGTTGAAGTAATTAGAAGATATATTAAGGTGTTCCTGGTAATG
AAGGCATGTAAGTTATAATAATTGTAGCTTTCTGAATAAGTGTCAAACTATATCTTTAAGTGTGCTGTATGCTGAGTTACAAGTTAGGTC

>9815_9815_4_BLNK-ZNF536_BLNK_chr10_98002491_ENST00000427367_ZNF536_chr19_31025754_ENST00000355537_length(amino acids)=644AA_BP=65
MDSYSCLLQLPNRMDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASDIGEEAGRSAGVQQPALLRDRSL
GSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPD
ILRGAFKGLPGIDFRGGPASQQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEIGRAYQSIVSNGVNFQGSLQAFMDSFV
LSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELM
ALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWTGHVDPAFCN
FPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSA
LSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLAAFNGLASST

--------------------------------------------------------------
>9815_9815_5_BLNK-ZNF536_BLNK_chr10_98002491_ENST00000495266_ZNF536_chr19_31025754_ENST00000355537_length(transcript)=2791nt_BP=163nt
ATGGACAAGCTTAATAAAATAACCGTCCCCGCCAGTCAGAAGTTGAGGCAGCTTCAAAAGATGGTCCATGATATTAAAAACAATGAAGGT
GGAATAATGAATAAAATCAAAAAGCTAAAAGTCAAAGCACCTCCAAGTGTTCCTCGAAGGGACTACGCTTCAGACATTGGCGAGGAGGCT
GGGAGATCTGCCGGCGTCCAGCAACCAGCGCTGCTTCGCGACAGAAGCCTGGGCTCGGCCATGAAGGACTGCCCGTACTGTGGGAAAACT
TTCCGGACATCCCATCACCTTAAGGTGCACCTGAGGATACACACAGGTGAGAAACCCTACAAGTGTCCGCACTGTGACTATGCCGGCACG
CAGTCAGCATCCTTAAAATACCACTTAGAGCGACACCATCGGGAGCGGCAGAACGGGGCTGGGCCGCTGTCTGGGCAACCCCCAAATCAA
GACCACAAGGATGAGATGTCAAGCAAAGCTTCTCTGTTCATCAGGCCAGACATCCTGAGGGGGGCCTTCAAGGGTCTCCCTGGAATCGAC
TTCAGAGGAGGCCCTGCATCTCAGCAGTGGACATCAGGGGTTCTCTCCTCTGGAGATCACTCGGGGCAGGCCACGGGCATGTCTTCGGAG
GTCCCCTCAGATGCTCTGAAAGGCACTGACCTTCCTTCCAAAAGCACCCACTTCTCTGAGATCGGAAGAGCTTATCAAAGCATTGTGAGC
AACGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCATGGACAGTTTTGTCCTCAGTTCCTTGAAGAAGGAGAAGGACATGAAGGACAAA
GCCCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGTGGATGGTGGTGAGGAGAAACCCAGTGGCAAGTCCTCCCAGAGGAAGTCCGAG
AAATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCCAGATGCCGCCTCCCTCCCGGGCTCCTCGGTAACTGTGCAGGACAGCATTGCA
TGGCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTCCATGGAGCTCATGGCCCTTCATCTCCAGGCCAACCACCTGGGCAAAGCGAAA
CGCAAAGATAACACCATCGGGGTCACAGTCAACTGCAAAGACCAAGCCCGGGAGGCGAGTAAGATGGCCCTGCTGCCCTCGTTACAATCA
AACAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCTAGACTCTGCTTCTGAGAAGATGGCCCAAGGTCAGCTCAAGGAGACTCTGGGA
GAGCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCCTGCATTTTGTAACTTCCCATCAGACTTCTACAAGCAGTTTGGTGTTTACCCA
GGCATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAACAAGGAGCCTGATGGAAAGGCCCACTCTGAAGAGGATGTCCCCATCCTGATC
CCCGAAACCACGAGTAAGAACACTACTGATGACCTCTCTGACATTGCCTCCTCAGAGGACATGGACTCCTCCAAGGGGGAGAACAACGAT
GAAGAGGATGTTGAAACCGAACCGGAAATGATGACCAAGCCACTGTCTGCCCTCAGCAAAGACAGCAGCAGCGATGGCGGGGACAGCCTG
CAGCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGTCTCACCTTTATCCCAAGCACCGGAGAAGCAGTGGCACAGCCAGGGTCTTCTC
CAAGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGAGCGGGGGCCCCAGAGCCTGGACAAGCCGATGAACATGCTGTCGGTCCTCAGG
GCCTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACTTGCAAGTAGCACAGCAAATTCTGGATGTATCAAGAGGCCAGACTTGTGTGGT
AAGTGACACTCCCTGTCCTAGTCGGTCTATCTGGACTTGCCCTTGTCTGTTCGTGGTCCTCGGTGGTTATCTGCAGCTTGTTAATCGTGT
AAAGTCAAGAGAAGAATGTATACACATATGTGTGTTGAATAATTACTATTGGCATAGGTATGTGTATACACACGGTGCACCAATCTACAG
TATATATAGCAGAGAATCAGAGGCTAAAAATATTACCCCATATGTTCCAGTATTAGTCATGGATTGCAAAGGCTTAGTAACTTGAGCAGG
AGAGAAAACTCCCTCAAAGTCATAAATCCTGAGTGACAACTGCTGCTGGATGACAGATCCCTTCACCTGTGGACAACCTGGCTGGGGGTG
GGGGGCTGTTCCACCAGCTCACCTGAGCATGTAGAGGTGGGTCCTGCAGTGGTCTCGTGGGTATTACTGCTTGTGTCTGATTGTCCTGTA
TTTTGTAACACTTTAGAAGAATACAGAAAAGTGCAGTAATTCTCTTTCTCCATAGTATTTAAGCAGAAATATTGCTAGTTTAATATTGTG
TCAGGTCGTCCTATTAACCAGGAGCAGATGACAGTAAAATTTCAGTGAATAGCACCTTGACATCTACAACTTAAAAATGGTGATTGAAGC
AAAATATGTAAACTTGTACGGGGTGATCGTGTGCTTTGGAACAGAGTATTGTTGAAGTAATTAGAAGATATATTAAGGTGTTCCTGGTAA
TGAAGGCATGTAAGTTATAATAATTGTAGCTTTCTGAATAAGTGTCAAACTATATCTTTAAGTGTGCTGTATGCTGAGTTACAAGTTAGG
TCATTTATGAATGGAATGTAAAATAATACTAAAAATGCTTCAATAACTTATCTTGGTATTGCTAATAAAAAAAAAAAGCTGTGAAACATT

>9815_9815_5_BLNK-ZNF536_BLNK_chr10_98002491_ENST00000495266_ZNF536_chr19_31025754_ENST00000355537_length(amino acids)=631AA_BP=52
MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKT
FRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPDILRGAFKGLPGID
FRGGPASQQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEIGRAYQSIVSNGVNFQGSLQAFMDSFVLSSLKKEKDMKDK
ALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHLQANHLGKAK
RKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWTGHVDPAFCNFPSDFYKQFGVYP
GMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSALSKDSSSDGGDSL
QPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLAAFNGLASSTANSGCIKRPDLCG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BLNK-ZNF536


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BLNK-ZNF536


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BLNK-ZNF536


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBLNKC0001768Agammaglobulinemia1CTD_human;GENOMICS_ENGLAND
HgeneBLNKC1832241Agammaglobulinemia, non-Bruton type1ORPHANET
HgeneBLNKC3150752AGAMMAGLOBULINEMIA 4, AUTOSOMAL RECESSIVE1GENOMICS_ENGLAND
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human