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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALG5-WBSCR17 (FusionGDB2 ID:HG29880TG64409)

Fusion Gene Summary for ALG5-WBSCR17

check button Fusion gene summary
Fusion gene informationFusion gene name: ALG5-WBSCR17
Fusion gene ID: hg29880tg64409
HgeneTgene
Gene symbol

ALG5

WBSCR17

Gene ID

29880

64409

Gene nameALG5 dolichyl-phosphate beta-glucosyltransferasepolypeptide N-acetylgalactosaminyltransferase 17
SynonymsbA421P11.2GALNACT17|GALNT16|GALNT20|GALNTL3|GalNAc-T17|GalNAc-T19|GalNAc-T5L|WBSCR17
Cytomap('ALG5')('WBSCR17')

13q13.3

7q11.22

Type of geneprotein-codingprotein-coding
Descriptiondolichyl-phosphate beta-glucosyltransferaseAlg5, S. cerevisiae, homolog ofasparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosyltransferase)asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glpolypeptide N-acetylgalactosaminyltransferase 17UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like 3UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminylt
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000239891, ENST00000413537, 
ENST00000443765, ENST00000496689, 
Fusion gene scores* DoF score5 X 4 X 4=805 X 3 X 5=75
# samples 55
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALG5 [Title/Abstract] AND WBSCR17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALG5(37559764)-WBSCR17(71175746), # samples:3
Anticipated loss of major functional domain due to fusion event.ALG5-WBSCR17 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALG5-WBSCR17 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ALG5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across WBSCR17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-G2-A2EF-01AALG5chr13

37559764

-WBSCR17chr7

71175746

+


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Fusion Gene ORF analysis for ALG5-WBSCR17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000239891ENST00000498380ALG5chr13

37559764

-WBSCR17chr7

71175746

+
5CDS-3UTRENST00000413537ENST00000498380ALG5chr13

37559764

-WBSCR17chr7

71175746

+
5CDS-3UTRENST00000443765ENST00000498380ALG5chr13

37559764

-WBSCR17chr7

71175746

+
In-frameENST00000239891ENST00000333538ALG5chr13

37559764

-WBSCR17chr7

71175746

+
In-frameENST00000413537ENST00000333538ALG5chr13

37559764

-WBSCR17chr7

71175746

+
In-frameENST00000443765ENST00000333538ALG5chr13

37559764

-WBSCR17chr7

71175746

+
intron-3CDSENST00000496689ENST00000333538ALG5chr13

37559764

-WBSCR17chr7

71175746

+
intron-3UTRENST00000496689ENST00000498380ALG5chr13

37559764

-WBSCR17chr7

71175746

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000443765ALG5chr1337559764-ENST00000333538WBSCR17chr771175746+228853867834255
ENST00000239891ALG5chr1337559764-ENST00000333538WBSCR17chr771175746+237862867924285
ENST00000413537ALG5chr1337559764-ENST00000333538WBSCR17chr771175746+234759736893285

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000443765ENST00000333538ALG5chr1337559764-WBSCR17chr771175746+0.0043652640.99563473
ENST00000239891ENST00000333538ALG5chr1337559764-WBSCR17chr771175746+0.0028791860.9971208
ENST00000413537ENST00000333538ALG5chr1337559764-WBSCR17chr771175746+0.0033519380.996648

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Fusion Genomic Features for ALG5-WBSCR17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ALG5chr1337559763-WBSCR17chr771175745+6.96E-091
ALG5chr1337559763-WBSCR17chr771175745+6.96E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ALG5-WBSCR17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:37559764/chr7:71175746)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALG5chr13:37559764chr7:71175746ENST00000239891-6101_7187325.0Topological domainCytoplasmic
HgeneALG5chr13:37559764chr7:71175746ENST00000443765-591_7157295.0Topological domainCytoplasmic
HgeneALG5chr13:37559764chr7:71175746ENST00000239891-6108_28187325.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneALG5chr13:37559764chr7:71175746ENST00000443765-598_28157295.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALG5chr13:37559764chr7:71175746ENST00000239891-61029_324187325.0Topological domainLumenal
HgeneALG5chr13:37559764chr7:71175746ENST00000443765-5929_324157295.0Topological domainLumenal
TgeneWBSCR17chr13:37559764chr7:71175746ENST00000333538811465_594500599.0DomainRicin B-type lectin
TgeneWBSCR17chr13:37559764chr7:71175746ENST00000333538811151_262500599.0RegionNote=Catalytic subdomain A
TgeneWBSCR17chr13:37559764chr7:71175746ENST00000333538811319_381500599.0RegionNote=Catalytic subdomain B
TgeneWBSCR17chr13:37559764chr7:71175746ENST000003335388111_6500599.0Topological domainCytoplasmic
TgeneWBSCR17chr13:37559764chr7:71175746ENST0000033353881128_598500599.0Topological domainLumenal
TgeneWBSCR17chr13:37559764chr7:71175746ENST000003335388117_27500599.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for ALG5-WBSCR17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4024_4024_1_ALG5-WBSCR17_ALG5_chr13_37559764_ENST00000239891_WBSCR17_chr7_71175746_ENST00000333538_length(transcript)=2378nt_BP=628nt
GGGTCGCGCGGGCGCGCTTCCGCCTGTGTGGAGGTGCGGGATTGGGCGGGCTGCCACGGCATGGAGAATGGCTCCGCTTCTGTTGCAGCT
GGCGGTGCTCGGCGCGGCGCTGGCGGCCGCAGCCCTCGTACTGATTTCCATCGTTGCATTTACAACTGCTACAAAAATGCCAGCACTCCA
TCGACATGAAGAAGAGAAATTCTTCTTAAATGCCAAAGGCCAGAAAGAAACTTTACCCAGCATATGGGACTCACCTACCAAACAACTTTC
TGTCGTTGTGCCTTCATACAATGAAGAAAAACGGTTGCCTGTGATGATGGATGAAGCTCTGAGCTATCTAGAGAAGAGACAGAAACGAGA
TCCTGCGTTCACTTATGAAGTGATAGTAGTTGATGATGGCAGTAAAGATCAGACCTCAAAGGTAGCTTTTAAATATTGCCAGAAATATGG
AAGTGACAAAGTACGTGTGATAACCCTGGTGAAGAATCGTGGAAAAGGTGGAGCGATTAGAATGGGTATATTCAGTTCTCGAGGAGAAAA
GATCCTTATGGCAGATGCTGATGGAGCCACAAAGTTTCCAGATGTTGAGAAATTAGAAAAGGGGCTAAATGATCTACAGCCTTGGCCTCT
TGCCCGCTACACCAAGGAAGGCTTCCTGCACTTGGGTGCCCTGGGGACCACCACACTCCTCCCTGACACCCGCTGCCTGGTGGACAACTC
CAAGAGTCGGCTGCCCCAGCTCCTGGACTGCGACAAGGTCAAGAGCAGCCTGTACAAGCGCTGGAACTTCATCCAGAATGGAGCCATCAT
GAACAAGGGCACGGGACGCTGCCTGGAGGTGGAGAACCGGGGCCTGGCTGGCATCGACCTCATCCTCCGCAGCTGCACAGGTCAGAGGTG
GACCATTAAGAACTCCATCAAGTAGAGGGAGGGAGCTGGGGCACTGGAGCCTGGCCCCCAGGACATGGCTGCTCCCCCCAACATCTGGAC
CAGCTGCCCTGGCGGAGAGACAGCAAGGGGCCGGCAGGTGCTCGATGGGCCCCCCAGGGCTTCTCCAGGGCAGCACAGGGACCCCGGATG
AAGACTCTGTCCCCCCTCAGGCATTCAGCTGCCCACAAGTTTCCTGCACCCTGGAAAAGCCCCCCACCCTTCCTCTGGGAAACTGACAGC
TGTCTTCCACAGCCTCTGATGTGGACCTGGTACTGAGGAGCAAGACTGTCCAGTTCTCCTCCACATCTCCCATCCCAGAATCAGGATCTG
GGACTGGCAGGGTCCCCTCCTGTGTCTCATCTCTTGCAGCAGCAGCTGCTGAACTCCAGCCATCAACACGGTGGGAGGCAGCGGGGGCTT
CAGCCATGTCCTAGCTCCCCGCCCTAAAAGGAGGCAGTGAGGACCAGGCACTATTTCCTCCGAGGTTACTTCTACCCAGATGACACCTGC
CTGTTCACGCCCCAAGGCAGCTACTGCCCCTAACCCTTCCCACCAGGGTAGCTTTGGGCACTGCAGCTCTGGACTTTTCTGGCCCCTCCT
GAGATGACCTGATGGAGCTGATGCTTTCTCTCCTAATCCCTGGGCACTAGGCTCTTATCAGTGTGCTTGGGCCAGCTCTCCTGCCTGTGT
CTAGAGGAAGCCAGAGACAGAAATAGGCTAAGCCTGCAGTAGGATCTCAGCCACAAGGGCCCCGCAGGATGGAGCTGGGTCAAGGACCAG
GGAGCCCTGACTCCCAGAGGCTGCCACCGGGGAGAAGCAGCGGTCCTCCATCCAGAACCTAAGGGCTGAAGCAAAGGCTGCCAGGACCCT
TGAAGATGCTTTTGGCTCACCTCATTTCACCCCACGCTCTGCTGGCTGGCAGAGGAGAAGGCAGTCGTTTCCTCTCTGAAGAGTATTTTT
TTCGATTGCCCTCTGGTTAGGGTGCACATATAAATCAGAGTTAATATATGAACGCGTGTGCATGCACAAGTGTGTGTGTGCCTGCGTGCT
GTGCGTGGCAGGGTGTGTGTGTGTGTGTCTGGCTGTGCGTTCCGGAGTGTGTGACGATGCTGACCTAGCTGTGTGGCCTTGGGCTTGCTG
CTTCATTACTCACCTGGATGGGGACGAGGGATGAGAAGGGTGTGGGTTTGGCCCCATGTCACTGGCCGGAAGGATGTGTCTCAGCCCTGC
CCTGTGGGGTGCCCCCGATGGGAGGCTGTCCCATCTCCCAGTCCCCATCTCTTTTTCCCCACACTGTCCCTGGCCAAGCCCTGCCCAGAG
CTGAACCCTGTAGCTGCCCCCTTGCCCTGTGTGGGATTCGCAGTGTCTCATTTGGTGACGTCTTACTGGTGATCATCTCCTCACCCCATC

>4024_4024_1_ALG5-WBSCR17_ALG5_chr13_37559764_ENST00000239891_WBSCR17_chr7_71175746_ENST00000333538_length(amino acids)=285AA_BP=187
MAPLLLQLAVLGAALAAAALVLISIVAFTTATKMPALHRHEEEKFFLNAKGQKETLPSIWDSPTKQLSVVVPSYNEEKRLPVMMDEALSY
LEKRQKRDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGATKFPDVEKLEKGL
NDLQPWPLARYTKEGFLHLGALGTTTLLPDTRCLVDNSKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNKGTGRCLEVENRGLAGIDLIL

--------------------------------------------------------------
>4024_4024_2_ALG5-WBSCR17_ALG5_chr13_37559764_ENST00000413537_WBSCR17_chr7_71175746_ENST00000333538_length(transcript)=2347nt_BP=597nt
AGGTGCGGGATTGGGCGGGCTGCCACGGCATGGAGAATGGCTCCGCTTCTGTTGCAGCTGGCGGTGCTCGGCGCGGCGCTGGCGGCCGCA
GCCCTCGTACTGATTTCCATCGTTGCATTTACAACTGCTACAAAAATGCCAGCACTCCATCGACATGAAGAAGAGAAATTCTTCTTAAAT
GCCAAAGGCCAGAAAGAAACTTTACCCAGCATATGGGACTCACCTACCAAACAACTTTCTGTCGTTGTGCCTTCATACAATGAAGAAAAA
CGGTTGCCTGTGATGATGGATGAAGCTCTGAGCTATCTAGAGAAGAGACAGAAACGAGATCCTGCGTTCACTTATGAAGTGATAGTAGTT
GATGATGGCAGTAAAGATCAGACCTCAAAGGTAGCTTTTAAATATTGCCAGAAATATGGAAGTGACAAAGTACGTGTGATAACCCTGGTG
AAGAATCGTGGAAAAGGTGGAGCGATTAGAATGGGTATATTCAGTTCTCGAGGAGAAAAGATCCTTATGGCAGATGCTGATGGAGCCACA
AAGTTTCCAGATGTTGAGAAATTAGAAAAGGGGCTAAATGATCTACAGCCTTGGCCTCTTGCCCGCTACACCAAGGAAGGCTTCCTGCAC
TTGGGTGCCCTGGGGACCACCACACTCCTCCCTGACACCCGCTGCCTGGTGGACAACTCCAAGAGTCGGCTGCCCCAGCTCCTGGACTGC
GACAAGGTCAAGAGCAGCCTGTACAAGCGCTGGAACTTCATCCAGAATGGAGCCATCATGAACAAGGGCACGGGACGCTGCCTGGAGGTG
GAGAACCGGGGCCTGGCTGGCATCGACCTCATCCTCCGCAGCTGCACAGGTCAGAGGTGGACCATTAAGAACTCCATCAAGTAGAGGGAG
GGAGCTGGGGCACTGGAGCCTGGCCCCCAGGACATGGCTGCTCCCCCCAACATCTGGACCAGCTGCCCTGGCGGAGAGACAGCAAGGGGC
CGGCAGGTGCTCGATGGGCCCCCCAGGGCTTCTCCAGGGCAGCACAGGGACCCCGGATGAAGACTCTGTCCCCCCTCAGGCATTCAGCTG
CCCACAAGTTTCCTGCACCCTGGAAAAGCCCCCCACCCTTCCTCTGGGAAACTGACAGCTGTCTTCCACAGCCTCTGATGTGGACCTGGT
ACTGAGGAGCAAGACTGTCCAGTTCTCCTCCACATCTCCCATCCCAGAATCAGGATCTGGGACTGGCAGGGTCCCCTCCTGTGTCTCATC
TCTTGCAGCAGCAGCTGCTGAACTCCAGCCATCAACACGGTGGGAGGCAGCGGGGGCTTCAGCCATGTCCTAGCTCCCCGCCCTAAAAGG
AGGCAGTGAGGACCAGGCACTATTTCCTCCGAGGTTACTTCTACCCAGATGACACCTGCCTGTTCACGCCCCAAGGCAGCTACTGCCCCT
AACCCTTCCCACCAGGGTAGCTTTGGGCACTGCAGCTCTGGACTTTTCTGGCCCCTCCTGAGATGACCTGATGGAGCTGATGCTTTCTCT
CCTAATCCCTGGGCACTAGGCTCTTATCAGTGTGCTTGGGCCAGCTCTCCTGCCTGTGTCTAGAGGAAGCCAGAGACAGAAATAGGCTAA
GCCTGCAGTAGGATCTCAGCCACAAGGGCCCCGCAGGATGGAGCTGGGTCAAGGACCAGGGAGCCCTGACTCCCAGAGGCTGCCACCGGG
GAGAAGCAGCGGTCCTCCATCCAGAACCTAAGGGCTGAAGCAAAGGCTGCCAGGACCCTTGAAGATGCTTTTGGCTCACCTCATTTCACC
CCACGCTCTGCTGGCTGGCAGAGGAGAAGGCAGTCGTTTCCTCTCTGAAGAGTATTTTTTTCGATTGCCCTCTGGTTAGGGTGCACATAT
AAATCAGAGTTAATATATGAACGCGTGTGCATGCACAAGTGTGTGTGTGCCTGCGTGCTGTGCGTGGCAGGGTGTGTGTGTGTGTGTCTG
GCTGTGCGTTCCGGAGTGTGTGACGATGCTGACCTAGCTGTGTGGCCTTGGGCTTGCTGCTTCATTACTCACCTGGATGGGGACGAGGGA
TGAGAAGGGTGTGGGTTTGGCCCCATGTCACTGGCCGGAAGGATGTGTCTCAGCCCTGCCCTGTGGGGTGCCCCCGATGGGAGGCTGTCC
CATCTCCCAGTCCCCATCTCTTTTTCCCCACACTGTCCCTGGCCAAGCCCTGCCCAGAGCTGAACCCTGTAGCTGCCCCCTTGCCCTGTG
TGGGATTCGCAGTGTCTCATTTGGTGACGTCTTACTGGTGATCATCTCCTCACCCCATCTCCCACCTTGTGGAATAAATACATGTTAGCA

>4024_4024_2_ALG5-WBSCR17_ALG5_chr13_37559764_ENST00000413537_WBSCR17_chr7_71175746_ENST00000333538_length(amino acids)=285AA_BP=187
MAPLLLQLAVLGAALAAAALVLISIVAFTTATKMPALHRHEEEKFFLNAKGQKETLPSIWDSPTKQLSVVVPSYNEEKRLPVMMDEALSY
LEKRQKRDPAFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGATKFPDVEKLEKGL
NDLQPWPLARYTKEGFLHLGALGTTTLLPDTRCLVDNSKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNKGTGRCLEVENRGLAGIDLIL

--------------------------------------------------------------
>4024_4024_3_ALG5-WBSCR17_ALG5_chr13_37559764_ENST00000443765_WBSCR17_chr7_71175746_ENST00000333538_length(transcript)=2288nt_BP=538nt
GGGTCGCGCGGGCGCGCTTCCGCCTGTGTGGAGGTGCGGGATTGGGCGGGCTGCCACGGCATGGAGAATGGCTCCGCTTCTGTTGCAGCT
GGCGGTGCTCGGCGCGGCGCTGGCGGCCGCAGCCCTCGTACTGATTTCCATCGTTGCATTTACAACTGCTACAAAAATGCCAGCACTCCA
TCGACATGAAGAAGAGAAATTCTTCTTAAATGCCAAAGGCCAGAAAGAAACTTTACCCAGCATATGGGACTCACCTACCAAACAACTTTC
TGTCGTTGTGCCTTCATACAATGAAGAAAAACGGTTGCCTGTGATGATGGATGAAGCTCTGAGCTATCTAGAGAAGAGACAGAAATATGG
AAGTGACAAAGTACGTGTGATAACCCTGGTGAAGAATCGTGGAAAAGGTGGAGCGATTAGAATGGGTATATTCAGTTCTCGAGGAGAAAA
GATCCTTATGGCAGATGCTGATGGAGCCACAAAGTTTCCAGATGTTGAGAAATTAGAAAAGGGGCTAAATGATCTACAGCCTTGGCCTCT
TGCCCGCTACACCAAGGAAGGCTTCCTGCACTTGGGTGCCCTGGGGACCACCACACTCCTCCCTGACACCCGCTGCCTGGTGGACAACTC
CAAGAGTCGGCTGCCCCAGCTCCTGGACTGCGACAAGGTCAAGAGCAGCCTGTACAAGCGCTGGAACTTCATCCAGAATGGAGCCATCAT
GAACAAGGGCACGGGACGCTGCCTGGAGGTGGAGAACCGGGGCCTGGCTGGCATCGACCTCATCCTCCGCAGCTGCACAGGTCAGAGGTG
GACCATTAAGAACTCCATCAAGTAGAGGGAGGGAGCTGGGGCACTGGAGCCTGGCCCCCAGGACATGGCTGCTCCCCCCAACATCTGGAC
CAGCTGCCCTGGCGGAGAGACAGCAAGGGGCCGGCAGGTGCTCGATGGGCCCCCCAGGGCTTCTCCAGGGCAGCACAGGGACCCCGGATG
AAGACTCTGTCCCCCCTCAGGCATTCAGCTGCCCACAAGTTTCCTGCACCCTGGAAAAGCCCCCCACCCTTCCTCTGGGAAACTGACAGC
TGTCTTCCACAGCCTCTGATGTGGACCTGGTACTGAGGAGCAAGACTGTCCAGTTCTCCTCCACATCTCCCATCCCAGAATCAGGATCTG
GGACTGGCAGGGTCCCCTCCTGTGTCTCATCTCTTGCAGCAGCAGCTGCTGAACTCCAGCCATCAACACGGTGGGAGGCAGCGGGGGCTT
CAGCCATGTCCTAGCTCCCCGCCCTAAAAGGAGGCAGTGAGGACCAGGCACTATTTCCTCCGAGGTTACTTCTACCCAGATGACACCTGC
CTGTTCACGCCCCAAGGCAGCTACTGCCCCTAACCCTTCCCACCAGGGTAGCTTTGGGCACTGCAGCTCTGGACTTTTCTGGCCCCTCCT
GAGATGACCTGATGGAGCTGATGCTTTCTCTCCTAATCCCTGGGCACTAGGCTCTTATCAGTGTGCTTGGGCCAGCTCTCCTGCCTGTGT
CTAGAGGAAGCCAGAGACAGAAATAGGCTAAGCCTGCAGTAGGATCTCAGCCACAAGGGCCCCGCAGGATGGAGCTGGGTCAAGGACCAG
GGAGCCCTGACTCCCAGAGGCTGCCACCGGGGAGAAGCAGCGGTCCTCCATCCAGAACCTAAGGGCTGAAGCAAAGGCTGCCAGGACCCT
TGAAGATGCTTTTGGCTCACCTCATTTCACCCCACGCTCTGCTGGCTGGCAGAGGAGAAGGCAGTCGTTTCCTCTCTGAAGAGTATTTTT
TTCGATTGCCCTCTGGTTAGGGTGCACATATAAATCAGAGTTAATATATGAACGCGTGTGCATGCACAAGTGTGTGTGTGCCTGCGTGCT
GTGCGTGGCAGGGTGTGTGTGTGTGTGTCTGGCTGTGCGTTCCGGAGTGTGTGACGATGCTGACCTAGCTGTGTGGCCTTGGGCTTGCTG
CTTCATTACTCACCTGGATGGGGACGAGGGATGAGAAGGGTGTGGGTTTGGCCCCATGTCACTGGCCGGAAGGATGTGTCTCAGCCCTGC
CCTGTGGGGTGCCCCCGATGGGAGGCTGTCCCATCTCCCAGTCCCCATCTCTTTTTCCCCACACTGTCCCTGGCCAAGCCCTGCCCAGAG
CTGAACCCTGTAGCTGCCCCCTTGCCCTGTGTGGGATTCGCAGTGTCTCATTTGGTGACGTCTTACTGGTGATCATCTCCTCACCCCATC

>4024_4024_3_ALG5-WBSCR17_ALG5_chr13_37559764_ENST00000443765_WBSCR17_chr7_71175746_ENST00000333538_length(amino acids)=255AA_BP=157
MAPLLLQLAVLGAALAAAALVLISIVAFTTATKMPALHRHEEEKFFLNAKGQKETLPSIWDSPTKQLSVVVPSYNEEKRLPVMMDEALSY
LEKRQKYGSDKVRVITLVKNRGKGGAIRMGIFSSRGEKILMADADGATKFPDVEKLEKGLNDLQPWPLARYTKEGFLHLGALGTTTLLPD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ALG5-WBSCR17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALG5-WBSCR17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALG5-WBSCR17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource