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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANXA1-ARPC3 (FusionGDB2 ID:HG301TG10094)

Fusion Gene Summary for ANXA1-ARPC3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANXA1-ARPC3
Fusion gene ID: hg301tg10094
HgeneTgene
Gene symbol

ANXA1

ARPC3

Gene ID

301

10094

Gene nameannexin A1actin related protein 2/3 complex subunit 3
SynonymsANX1|LPC1ARC21|p21-Arc
Cytomap('ANXA1')('ARPC3')

9q21.13

12q24.11

Type of geneprotein-codingprotein-coding
Descriptionannexin A1annexin I (lipocortin I)annexin-1calpactin IIcalpactin-2chromobindin-9epididymis secretory sperm binding proteinphospholipase A2 inhibitory proteinactin-related protein 2/3 complex subunit 3ARP2/3 protein complex subunit p21actin related protein 2/3 complex, subunit 3, 21kDaarp2/3 complex 21 kDa subunit
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000257497, ENST00000376911, 
ENST00000491192, 
Fusion gene scores* DoF score6 X 6 X 3=1086 X 4 X 4=96
# samples 67
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANXA1 [Title/Abstract] AND ARPC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANXA1(75775232)-ARPC3(110878152), # samples:1
Anticipated loss of major functional domain due to fusion event.ANXA1-ARPC3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ANXA1-ARPC3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANXA1

GO:0002548

monocyte chemotaxis

15187149

HgeneANXA1

GO:0007187

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

25664854

HgeneANXA1

GO:0008360

regulation of cell shape

15187149

HgeneANXA1

GO:0018149

peptide cross-linking

10908733

HgeneANXA1

GO:0030216

keratinocyte differentiation

10908733

HgeneANXA1

GO:0031340

positive regulation of vesicle fusion

2138016

HgeneANXA1

GO:0031532

actin cytoskeleton reorganization

15187149

HgeneANXA1

GO:0032743

positive regulation of interleukin-2 production

17008549

HgeneANXA1

GO:0035924

cellular response to vascular endothelial growth factor stimulus

22773844

HgeneANXA1

GO:0042102

positive regulation of T cell proliferation

17008549

HgeneANXA1

GO:0045627

positive regulation of T-helper 1 cell differentiation

17008549

HgeneANXA1

GO:0045629

negative regulation of T-helper 2 cell differentiation

17008549

HgeneANXA1

GO:0071385

cellular response to glucocorticoid stimulus

2936963

HgeneANXA1

GO:0071621

granulocyte chemotaxis

15187149

HgeneANXA1

GO:0090050

positive regulation of cell migration involved in sprouting angiogenesis

22773844

HgeneANXA1

GO:0090303

positive regulation of wound healing

25664854

TgeneARPC3

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for ANXA1-ARPC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANXA1-ARPC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ANXA1-ARPC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:75775232/:110878152)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANXA1-ARPC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANXA1-ARPC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANXA1-ARPC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANXA1-ARPC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANXA1C0024667Animal Mammary Neoplasms3CTD_human
HgeneANXA1C1257925Mammary Carcinoma, Animal3CTD_human
HgeneANXA1C0007097Carcinoma2CTD_human
HgeneANXA1C0024668Mammary Neoplasms, Experimental2CTD_human
HgeneANXA1C0205696Anaplastic carcinoma2CTD_human
HgeneANXA1C0205697Carcinoma, Spindle-Cell2CTD_human
HgeneANXA1C0205698Undifferentiated carcinoma2CTD_human
HgeneANXA1C0205699Carcinomatosis2CTD_human
HgeneANXA1C0007137Squamous cell carcinoma1CTD_human
HgeneANXA1C0020538Hypertensive disease1CTD_human
HgeneANXA1C0022658Kidney Diseases1CTD_human
HgeneANXA1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneANXA1C0024232Lymphatic Metastasis1CTD_human
HgeneANXA1C0026640Mouth Neoplasms1CTD_human
HgeneANXA1C0027626Neoplasm Invasiveness1CTD_human
HgeneANXA1C0027627Neoplasm Metastasis1CTD_human
HgeneANXA1C0033578Prostatic Neoplasms1CTD_human
HgeneANXA1C0038354Stomach Diseases1CTD_human
HgeneANXA1C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneANXA1C0153381Malignant neoplasm of mouth1CTD_human
HgeneANXA1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneANXA1C0376358Malignant neoplasm of prostate1CTD_human
HgeneANXA1C0376634Craniofacial Abnormalities1CTD_human