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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HADH-ZP2 (FusionGDB2 ID:HG3033TG7783)

Fusion Gene Summary for HADH-ZP2

check button Fusion gene summary
Fusion gene informationFusion gene name: HADH-ZP2
Fusion gene ID: hg3033tg7783
HgeneTgene
Gene symbol

HADH

ZP2

Gene ID

3033

7783

Gene namehydroxyacyl-CoA dehydrogenasezona pellucida glycoprotein 2
SynonymsHAD|HADH1|HADHSC|HCDH|HHF4|MSCHAD|SCHADOOMD6|ZPA|Zp-2
Cytomap('HADH')('ZP2')

4q25

16p12.3-p12.2

Type of geneprotein-codingprotein-coding
Descriptionhydroxyacyl-coenzyme A dehydrogenase, mitochondrialL-3-hydroxyacyl-Coenzyme A dehydrogenase, short chainmedium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenaseshort-chain 3-hydroxyacyl-CoA dehydrogenasetestis secretory sperm-binding protein Lizona pellucida sperm-binding protein 2zona pellucida glycoprotein 2 (sperm receptor)zona pellucida glycoprotein ZP2zona pellucida protein A
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000505878, ENST00000309522, 
ENST00000403312, ENST00000603302, 
ENST00000454409, ENST00000510728, 
Fusion gene scores* DoF score7 X 6 X 3=1261 X 1 X 1=1
# samples 71
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: HADH [Title/Abstract] AND ZP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHADH(108911220)-ZP2(21214572), # samples:3
Anticipated loss of major functional domain due to fusion event.HADH-ZP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HADH-ZP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZP2

GO:0060046

regulation of acrosome reaction

11751269|20394732


check buttonFusion gene breakpoints across HADH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-HZ-7925-01AHADHchr4

108911220

-ZP2chr16

21214572

-
ChimerDB4PAADTCGA-HZ-7925-01AHADHchr4

108911220

+ZP2chr16

21214572

-
ChimerDB4PAADTCGA-HZ-7925HADHchr4

108911220

+ZP2chr16

21214572

-


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Fusion Gene ORF analysis for HADH-ZP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000505878ENST00000219593HADHchr4

108911220

+ZP2chr16

21214572

-
5UTR-3CDSENST00000505878ENST00000574002HADHchr4

108911220

+ZP2chr16

21214572

-
5UTR-3CDSENST00000505878ENST00000574091HADHchr4

108911220

+ZP2chr16

21214572

-
In-frameENST00000309522ENST00000219593HADHchr4

108911220

+ZP2chr16

21214572

-
In-frameENST00000309522ENST00000574002HADHchr4

108911220

+ZP2chr16

21214572

-
In-frameENST00000309522ENST00000574091HADHchr4

108911220

+ZP2chr16

21214572

-
In-frameENST00000403312ENST00000219593HADHchr4

108911220

+ZP2chr16

21214572

-
In-frameENST00000403312ENST00000574002HADHchr4

108911220

+ZP2chr16

21214572

-
In-frameENST00000403312ENST00000574091HADHchr4

108911220

+ZP2chr16

21214572

-
In-frameENST00000603302ENST00000219593HADHchr4

108911220

+ZP2chr16

21214572

-
In-frameENST00000603302ENST00000574002HADHchr4

108911220

+ZP2chr16

21214572

-
In-frameENST00000603302ENST00000574091HADHchr4

108911220

+ZP2chr16

21214572

-
intron-3CDSENST00000454409ENST00000219593HADHchr4

108911220

+ZP2chr16

21214572

-
intron-3CDSENST00000454409ENST00000574002HADHchr4

108911220

+ZP2chr16

21214572

-
intron-3CDSENST00000454409ENST00000574091HADHchr4

108911220

+ZP2chr16

21214572

-
intron-3CDSENST00000510728ENST00000219593HADHchr4

108911220

+ZP2chr16

21214572

-
intron-3CDSENST00000510728ENST00000574002HADHchr4

108911220

+ZP2chr16

21214572

-
intron-3CDSENST00000510728ENST00000574091HADHchr4

108911220

+ZP2chr16

21214572

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000603302HADHchr4108911220+ENST00000574091ZP2chr1621214572-1618351421589515
ENST00000603302HADHchr4108911220+ENST00000219593ZP2chr1621214572-1645351421616524
ENST00000603302HADHchr4108911220+ENST00000574002ZP2chr1621214572-1645351421616524
ENST00000403312HADHchr4108911220+ENST00000574091ZP2chr1621214572-1618351421589515
ENST00000403312HADHchr4108911220+ENST00000219593ZP2chr1621214572-1645351421616524
ENST00000403312HADHchr4108911220+ENST00000574002ZP2chr1621214572-1645351421616524
ENST00000309522HADHchr4108911220+ENST00000574091ZP2chr1621214572-1548281411519492
ENST00000309522HADHchr4108911220+ENST00000219593ZP2chr1621214572-1575281411546501
ENST00000309522HADHchr4108911220+ENST00000574002ZP2chr1621214572-1575281411546501

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000603302ENST00000574091HADHchr4108911220+ZP2chr1621214572-0.0029717220.9970283
ENST00000603302ENST00000219593HADHchr4108911220+ZP2chr1621214572-0.0040506470.9959494
ENST00000603302ENST00000574002HADHchr4108911220+ZP2chr1621214572-0.0040506470.9959494
ENST00000403312ENST00000574091HADHchr4108911220+ZP2chr1621214572-0.0029717220.9970283
ENST00000403312ENST00000219593HADHchr4108911220+ZP2chr1621214572-0.0040506470.9959494
ENST00000403312ENST00000574002HADHchr4108911220+ZP2chr1621214572-0.0040506470.9959494
ENST00000309522ENST00000574091HADHchr4108911220+ZP2chr1621214572-0.0015984830.99840146
ENST00000309522ENST00000219593HADHchr4108911220+ZP2chr1621214572-0.0010832660.99891675
ENST00000309522ENST00000574002HADHchr4108911220+ZP2chr1621214572-0.0010832660.99891675

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Fusion Genomic Features for HADH-ZP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for HADH-ZP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:108911220/chr16:21214572)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHADHchr4:108911220chr16:21214572ENST00000309522+1834_3944315.0Nucleotide bindingNAD
HgeneHADHchr4:108911220chr16:21214572ENST00000603302+1934_3944332.0Nucleotide bindingNAD
TgeneZP2chr4:108911220chr16:21214572ENST00000219593819371_637324746.0DomainZP
TgeneZP2chr4:108911220chr16:21214572ENST00000574002920371_637324746.0DomainZP
TgeneZP2chr4:108911220chr16:21214572ENST00000219593819469_491324746.0RegionDisordered
TgeneZP2chr4:108911220chr16:21214572ENST00000574002920469_491324746.0RegionDisordered
TgeneZP2chr4:108911220chr16:21214572ENST00000219593819737_745324746.0Topological domainCytoplasmic
TgeneZP2chr4:108911220chr16:21214572ENST00000574002920737_745324746.0Topological domainCytoplasmic
TgeneZP2chr4:108911220chr16:21214572ENST00000219593819717_736324746.0TransmembraneHelical
TgeneZP2chr4:108911220chr16:21214572ENST00000574002920717_736324746.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZP2chr4:108911220chr16:21214572ENST0000021959381939_716324746.0Topological domainExtracellular
TgeneZP2chr4:108911220chr16:21214572ENST0000057400292039_716324746.0Topological domainExtracellular


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Fusion Gene Sequence for HADH-ZP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35587_35587_1_HADH-ZP2_HADH_chr4_108911220_ENST00000309522_ZP2_chr16_21214572_ENST00000219593_length(transcript)=1575nt_BP=281nt
CCCCGCCTTGTGGCGTCACGGGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCT
GCCCGCCTCGCGCGTCTTCCCTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTT
CCGTGTCCTCCTCGTCCACCGCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCG
GCATTGCCCAGTTATCTGAAAAATGCCTACTCCATCAGTTCTACTTAGCTTCACTCAAGCTGACCTTTCTCCTTCGGCCAGAGACAGTAT
CCATGGTGATCTATCCTGAGTGTCTCTGTGAGTCACCCGTTTCTATAGTTACAGGGGAGCTGTGCACCCAGGATGGGTTTATGGACGTCG
AGGTCTACAGCTACCAAACACAACCAGCTCTTGACCTGGGTACTCTGAGGGTGGGAAACTCATCCTGCCAGCCTGTCTTTGAGGCTCAGT
CTCAGGGGCTGGTACGGTTCCACATACCCCTGAATGGATGTGGAACGAGATATAAGTTCGAAGATGATAAAGTCGTCTATGAAAACGAAA
TACATGCTCTCTGGACGGATTTTCCTCCAAGCAAAATATCTAGAGACAGTGAGTTCAGAATGACAGTGAAGTGTTCTTATAGCAGGAATG
ACATGCTACTAAACATCAACGTTGAAAGCCTTACTCCTCCAGTGGCCTCAGTGAAGTTGGGTCCATTTACCTTGATCCTGCAAAGCTACC
CAGATAATTCCTACCAACAACCTTATGGGGAAAACGAGTACCCTCTAGTGAGATTCCTCCGCCAACCAATTTACATGGAAGTGAGAGTCC
TAAACAGGGATGACCCCAACATCAAGCTGGTCTTAGATGACTGCTGGGCGACGTCCACCATGGATCCAGACTCTTTCCCCCAGTGGAACG
TTGTCGTGGATGGCTGTGCATATGACCTGGACAACTACCAGACCACCTTCCATCCAGTCGGCTCCTCTGTGACCCATCCTGATCACTATC
AGAGGTTTGACATGAAGGCTTTTGCCTTTGTATCAGAAGCCCACGTGCTCTCTAGCCTGGTCTACTTCCACTGCAGTGCCTTAATCTGTA
ATCGACTCTCCCCTGACTCCCCACTGTGTTCTGTGACCTGCCCTGTGTCCTCTAGGCACAGGCGAGCCACAGGGGCCACTGAAGCAGAGA
AAATGACAGTCAGCCTCCCAGGACCCATTCTCCTGTTGTCAGATGACTCCTCATTCAGAGGTGTCGGCTCATCTGATCTAAAAGCAAGTG
GGAGCAGTGGGGAGAAGAGTAGGAGTGAAACAGGGGAGGAGGTTGGCTCACGAGGTGCTATGGACACCAAAGGGCACAAGACTGCTGGAG
ATGTTGGTTCCAAAGCTGTGGCTGCTGTGGCTGCCTTTGCAGGTGTGGTGGCAACTCTAGGCTTCATCTACTACCTGTACGAGAAAAGGA
CTGTGTCAAATCACTAAATGGGCTTCTAAATAAAGCAGTCAAAAT

>35587_35587_1_HADH-ZP2_HADH_chr4_108911220_ENST00000309522_ZP2_chr16_21214572_ENST00000219593_length(amino acids)=501AA_BP=79
MQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQLSEKCLLHQF
YLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNSSCQPVFEAQSQGLVRFHIPLNGC
GTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLGPFTLILQSYPDNSYQQPYGENEY
PLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVGSSVTHPDHYQRFDMKAFAFVSEA
HVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRGVGSSDLKASGSSGEKSRSETGEE
VGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH

--------------------------------------------------------------
>35587_35587_2_HADH-ZP2_HADH_chr4_108911220_ENST00000309522_ZP2_chr16_21214572_ENST00000574002_length(transcript)=1575nt_BP=281nt
CCCCGCCTTGTGGCGTCACGGGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCT
GCCCGCCTCGCGCGTCTTCCCTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTT
CCGTGTCCTCCTCGTCCACCGCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCG
GCATTGCCCAGTTATCTGAAAAATGCCTACTCCATCAGTTCTACTTAGCTTCACTCAAGCTGACCTTTCTCCTTCGGCCAGAGACAGTAT
CCATGGTGATCTATCCTGAGTGTCTCTGTGAGTCACCCGTTTCTATAGTTACAGGGGAGCTGTGCACCCAGGATGGGTTTATGGACGTCG
AGGTCTACAGCTACCAAACACAACCAGCTCTTGACCTGGGTACTCTGAGGGTGGGAAACTCATCCTGCCAGCCTGTCTTTGAGGCTCAGT
CTCAGGGGCTGGTACGGTTCCACATACCCCTGAATGGATGTGGAACGAGATATAAGTTCGAAGATGATAAAGTCGTCTATGAAAACGAAA
TACATGCTCTCTGGACGGATTTTCCTCCAAGCAAAATATCTAGAGACAGTGAGTTCAGAATGACAGTGAAGTGTTCTTATAGCAGGAATG
ACATGCTACTAAACATCAACGTTGAAAGCCTTACTCCTCCAGTGGCCTCAGTGAAGTTGGGTCCATTTACCTTGATCCTGCAAAGCTACC
CAGATAATTCCTACCAACAACCTTATGGGGAAAACGAGTACCCTCTAGTGAGATTCCTCCGCCAACCAATTTACATGGAAGTGAGAGTCC
TAAACAGGGATGACCCCAACATCAAGCTGGTCTTAGATGACTGCTGGGCGACGTCCACCATGGATCCAGACTCTTTCCCCCAGTGGAACG
TTGTCGTGGATGGCTGTGCATATGACCTGGACAACTACCAGACCACCTTCCATCCAGTCGGCTCCTCTGTGACCCATCCTGATCACTATC
AGAGGTTTGACATGAAGGCTTTTGCCTTTGTATCAGAAGCCCACGTGCTCTCTAGCCTGGTCTACTTCCACTGCAGTGCCTTAATCTGTA
ATCGACTCTCCCCTGACTCCCCACTGTGTTCTGTGACCTGCCCTGTGTCCTCTAGGCACAGGCGAGCCACAGGGGCCACTGAAGCAGAGA
AAATGACAGTCAGCCTCCCAGGACCCATTCTCCTGTTGTCAGATGACTCCTCATTCAGAGGTGTCGGCTCATCTGATCTAAAAGCAAGTG
GGAGCAGTGGGGAGAAGAGTAGGAGTGAAACAGGGGAGGAGGTTGGCTCACGAGGTGCTATGGACACCAAAGGGCACAAGACTGCTGGAG
ATGTTGGTTCCAAAGCTGTGGCTGCTGTGGCTGCCTTTGCAGGTGTGGTGGCAACTCTAGGCTTCATCTACTACCTGTACGAGAAAAGGA
CTGTGTCAAATCACTAAATGGGCTTCTAAATAAAGCAGTCAAAAT

>35587_35587_2_HADH-ZP2_HADH_chr4_108911220_ENST00000309522_ZP2_chr16_21214572_ENST00000574002_length(amino acids)=501AA_BP=79
MQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQLSEKCLLHQF
YLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNSSCQPVFEAQSQGLVRFHIPLNGC
GTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLGPFTLILQSYPDNSYQQPYGENEY
PLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVGSSVTHPDHYQRFDMKAFAFVSEA
HVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRGVGSSDLKASGSSGEKSRSETGEE
VGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH

--------------------------------------------------------------
>35587_35587_3_HADH-ZP2_HADH_chr4_108911220_ENST00000309522_ZP2_chr16_21214572_ENST00000574091_length(transcript)=1548nt_BP=281nt
CCCCGCCTTGTGGCGTCACGGGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCT
GCCCGCCTCGCGCGTCTTCCCTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTT
CCGTGTCCTCCTCGTCCACCGCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCG
GCATTGCCCAGTTATCTGAAAAATGCCTACTCCATCAGTTCTACTTAGCTTCACTCAAGCTGACCTTTCTCCTTCGGCCAGAGACAGTAT
CCATGGTGATCTATCCTGAGTGTCTCTGTGAGTCACCCGTTTCTATAGTTACAGGGGAGCTGTGCACCCAGGATGGGTTTATGGACGTCG
AGGTCTACAGCTACCAAACACAACCAGCTCTTGACCTGGGTACTCTGAGGGTGGGAAACTCATCCTGCCAGCCTGTCTTTGAGGCTCAGT
CTCAGGGGCTGGTACGGTTCCACATACCCCTGAATGGATGTGGAACGAGATATAAGTTCGAAGATGATAAAGTCGTCTATGAAAACGAAA
TACATGCTCTCTGGACGGATTTTCCTCCAAGCAAAATATCTAGAGACAGTGAGTTCAGGAATGACATGCTACTAAACATCAACGTTGAAA
GCCTTACTCCTCCAGTGGCCTCAGTGAAGTTGGGTCCATTTACCTTGATCCTGCAAAGCTACCCAGATAATTCCTACCAACAACCTTATG
GGGAAAACGAGTACCCTCTAGTGAGATTCCTCCGCCAACCAATTTACATGGAAGTGAGAGTCCTAAACAGGGATGACCCCAACATCAAGC
TGGTCTTAGATGACTGCTGGGCGACGTCCACCATGGATCCAGACTCTTTCCCCCAGTGGAACGTTGTCGTGGATGGCTGTGCATATGACC
TGGACAACTACCAGACCACCTTCCATCCAGTCGGCTCCTCTGTGACCCATCCTGATCACTATCAGAGGTTTGACATGAAGGCTTTTGCCT
TTGTATCAGAAGCCCACGTGCTCTCTAGCCTGGTCTACTTCCACTGCAGTGCCTTAATCTGTAATCGACTCTCCCCTGACTCCCCACTGT
GTTCTGTGACCTGCCCTGTGTCCTCTAGGCACAGGCGAGCCACAGGGGCCACTGAAGCAGAGAAAATGACAGTCAGCCTCCCAGGACCCA
TTCTCCTGTTGTCAGATGACTCCTCATTCAGAGGTGTCGGCTCATCTGATCTAAAAGCAAGTGGGAGCAGTGGGGAGAAGAGTAGGAGTG
AAACAGGGGAGGAGGTTGGCTCACGAGGTGCTATGGACACCAAAGGGCACAAGACTGCTGGAGATGTTGGTTCCAAAGCTGTGGCTGCTG
TGGCTGCCTTTGCAGGTGTGGTGGCAACTCTAGGCTTCATCTACTACCTGTACGAGAAAAGGACTGTGTCAAATCACTAAATGGGCTTCT
AAATAAAGCAGTCAAAAT

>35587_35587_3_HADH-ZP2_HADH_chr4_108911220_ENST00000309522_ZP2_chr16_21214572_ENST00000574091_length(amino acids)=492AA_BP=79
MQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQLSEKCLLHQF
YLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNSSCQPVFEAQSQGLVRFHIPLNGC
GTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRNDMLLNINVESLTPPVASVKLGPFTLILQSYPDNSYQQPYGENEYPLVRFLRQP
IYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVGSSVTHPDHYQRFDMKAFAFVSEAHVLSSLVYF
HCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRGVGSSDLKASGSSGEKSRSETGEEVGSRGAMDT
KGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH

--------------------------------------------------------------
>35587_35587_4_HADH-ZP2_HADH_chr4_108911220_ENST00000403312_ZP2_chr16_21214572_ENST00000219593_length(transcript)=1645nt_BP=351nt
CGTGTATACCCGCTCAACGCTGGGACGTTACAGCCAGGGCCAATGGGCAGAGCGGGACTCGAGGCCCCGCCCCCGCCTTGTGGCGTCACG
GGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCTGCCCGCCTCGCGCGTCTTCC
CTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACC
GCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGTTATCTGAA
AAATGCCTACTCCATCAGTTCTACTTAGCTTCACTCAAGCTGACCTTTCTCCTTCGGCCAGAGACAGTATCCATGGTGATCTATCCTGAG
TGTCTCTGTGAGTCACCCGTTTCTATAGTTACAGGGGAGCTGTGCACCCAGGATGGGTTTATGGACGTCGAGGTCTACAGCTACCAAACA
CAACCAGCTCTTGACCTGGGTACTCTGAGGGTGGGAAACTCATCCTGCCAGCCTGTCTTTGAGGCTCAGTCTCAGGGGCTGGTACGGTTC
CACATACCCCTGAATGGATGTGGAACGAGATATAAGTTCGAAGATGATAAAGTCGTCTATGAAAACGAAATACATGCTCTCTGGACGGAT
TTTCCTCCAAGCAAAATATCTAGAGACAGTGAGTTCAGAATGACAGTGAAGTGTTCTTATAGCAGGAATGACATGCTACTAAACATCAAC
GTTGAAAGCCTTACTCCTCCAGTGGCCTCAGTGAAGTTGGGTCCATTTACCTTGATCCTGCAAAGCTACCCAGATAATTCCTACCAACAA
CCTTATGGGGAAAACGAGTACCCTCTAGTGAGATTCCTCCGCCAACCAATTTACATGGAAGTGAGAGTCCTAAACAGGGATGACCCCAAC
ATCAAGCTGGTCTTAGATGACTGCTGGGCGACGTCCACCATGGATCCAGACTCTTTCCCCCAGTGGAACGTTGTCGTGGATGGCTGTGCA
TATGACCTGGACAACTACCAGACCACCTTCCATCCAGTCGGCTCCTCTGTGACCCATCCTGATCACTATCAGAGGTTTGACATGAAGGCT
TTTGCCTTTGTATCAGAAGCCCACGTGCTCTCTAGCCTGGTCTACTTCCACTGCAGTGCCTTAATCTGTAATCGACTCTCCCCTGACTCC
CCACTGTGTTCTGTGACCTGCCCTGTGTCCTCTAGGCACAGGCGAGCCACAGGGGCCACTGAAGCAGAGAAAATGACAGTCAGCCTCCCA
GGACCCATTCTCCTGTTGTCAGATGACTCCTCATTCAGAGGTGTCGGCTCATCTGATCTAAAAGCAAGTGGGAGCAGTGGGGAGAAGAGT
AGGAGTGAAACAGGGGAGGAGGTTGGCTCACGAGGTGCTATGGACACCAAAGGGCACAAGACTGCTGGAGATGTTGGTTCCAAAGCTGTG
GCTGCTGTGGCTGCCTTTGCAGGTGTGGTGGCAACTCTAGGCTTCATCTACTACCTGTACGAGAAAAGGACTGTGTCAAATCACTAAATG
GGCTTCTAAATAAAGCAGTCAAAAT

>35587_35587_4_HADH-ZP2_HADH_chr4_108911220_ENST00000403312_ZP2_chr16_21214572_ENST00000219593_length(amino acids)=524AA_BP=102
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVT
VIGGGLMGAGIAQLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNS
SCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLG
PFTLILQSYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVG
SSVTHPDHYQRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRG
VGSSDLKASGSSGEKSRSETGEEVGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH

--------------------------------------------------------------
>35587_35587_5_HADH-ZP2_HADH_chr4_108911220_ENST00000403312_ZP2_chr16_21214572_ENST00000574002_length(transcript)=1645nt_BP=351nt
CGTGTATACCCGCTCAACGCTGGGACGTTACAGCCAGGGCCAATGGGCAGAGCGGGACTCGAGGCCCCGCCCCCGCCTTGTGGCGTCACG
GGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCTGCCCGCCTCGCGCGTCTTCC
CTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACC
GCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGTTATCTGAA
AAATGCCTACTCCATCAGTTCTACTTAGCTTCACTCAAGCTGACCTTTCTCCTTCGGCCAGAGACAGTATCCATGGTGATCTATCCTGAG
TGTCTCTGTGAGTCACCCGTTTCTATAGTTACAGGGGAGCTGTGCACCCAGGATGGGTTTATGGACGTCGAGGTCTACAGCTACCAAACA
CAACCAGCTCTTGACCTGGGTACTCTGAGGGTGGGAAACTCATCCTGCCAGCCTGTCTTTGAGGCTCAGTCTCAGGGGCTGGTACGGTTC
CACATACCCCTGAATGGATGTGGAACGAGATATAAGTTCGAAGATGATAAAGTCGTCTATGAAAACGAAATACATGCTCTCTGGACGGAT
TTTCCTCCAAGCAAAATATCTAGAGACAGTGAGTTCAGAATGACAGTGAAGTGTTCTTATAGCAGGAATGACATGCTACTAAACATCAAC
GTTGAAAGCCTTACTCCTCCAGTGGCCTCAGTGAAGTTGGGTCCATTTACCTTGATCCTGCAAAGCTACCCAGATAATTCCTACCAACAA
CCTTATGGGGAAAACGAGTACCCTCTAGTGAGATTCCTCCGCCAACCAATTTACATGGAAGTGAGAGTCCTAAACAGGGATGACCCCAAC
ATCAAGCTGGTCTTAGATGACTGCTGGGCGACGTCCACCATGGATCCAGACTCTTTCCCCCAGTGGAACGTTGTCGTGGATGGCTGTGCA
TATGACCTGGACAACTACCAGACCACCTTCCATCCAGTCGGCTCCTCTGTGACCCATCCTGATCACTATCAGAGGTTTGACATGAAGGCT
TTTGCCTTTGTATCAGAAGCCCACGTGCTCTCTAGCCTGGTCTACTTCCACTGCAGTGCCTTAATCTGTAATCGACTCTCCCCTGACTCC
CCACTGTGTTCTGTGACCTGCCCTGTGTCCTCTAGGCACAGGCGAGCCACAGGGGCCACTGAAGCAGAGAAAATGACAGTCAGCCTCCCA
GGACCCATTCTCCTGTTGTCAGATGACTCCTCATTCAGAGGTGTCGGCTCATCTGATCTAAAAGCAAGTGGGAGCAGTGGGGAGAAGAGT
AGGAGTGAAACAGGGGAGGAGGTTGGCTCACGAGGTGCTATGGACACCAAAGGGCACAAGACTGCTGGAGATGTTGGTTCCAAAGCTGTG
GCTGCTGTGGCTGCCTTTGCAGGTGTGGTGGCAACTCTAGGCTTCATCTACTACCTGTACGAGAAAAGGACTGTGTCAAATCACTAAATG
GGCTTCTAAATAAAGCAGTCAAAAT

>35587_35587_5_HADH-ZP2_HADH_chr4_108911220_ENST00000403312_ZP2_chr16_21214572_ENST00000574002_length(amino acids)=524AA_BP=102
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVT
VIGGGLMGAGIAQLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNS
SCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLG
PFTLILQSYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVG
SSVTHPDHYQRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRG
VGSSDLKASGSSGEKSRSETGEEVGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH

--------------------------------------------------------------
>35587_35587_6_HADH-ZP2_HADH_chr4_108911220_ENST00000403312_ZP2_chr16_21214572_ENST00000574091_length(transcript)=1618nt_BP=351nt
CGTGTATACCCGCTCAACGCTGGGACGTTACAGCCAGGGCCAATGGGCAGAGCGGGACTCGAGGCCCCGCCCCCGCCTTGTGGCGTCACG
GGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCTGCCCGCCTCGCGCGTCTTCC
CTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACC
GCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGTTATCTGAA
AAATGCCTACTCCATCAGTTCTACTTAGCTTCACTCAAGCTGACCTTTCTCCTTCGGCCAGAGACAGTATCCATGGTGATCTATCCTGAG
TGTCTCTGTGAGTCACCCGTTTCTATAGTTACAGGGGAGCTGTGCACCCAGGATGGGTTTATGGACGTCGAGGTCTACAGCTACCAAACA
CAACCAGCTCTTGACCTGGGTACTCTGAGGGTGGGAAACTCATCCTGCCAGCCTGTCTTTGAGGCTCAGTCTCAGGGGCTGGTACGGTTC
CACATACCCCTGAATGGATGTGGAACGAGATATAAGTTCGAAGATGATAAAGTCGTCTATGAAAACGAAATACATGCTCTCTGGACGGAT
TTTCCTCCAAGCAAAATATCTAGAGACAGTGAGTTCAGGAATGACATGCTACTAAACATCAACGTTGAAAGCCTTACTCCTCCAGTGGCC
TCAGTGAAGTTGGGTCCATTTACCTTGATCCTGCAAAGCTACCCAGATAATTCCTACCAACAACCTTATGGGGAAAACGAGTACCCTCTA
GTGAGATTCCTCCGCCAACCAATTTACATGGAAGTGAGAGTCCTAAACAGGGATGACCCCAACATCAAGCTGGTCTTAGATGACTGCTGG
GCGACGTCCACCATGGATCCAGACTCTTTCCCCCAGTGGAACGTTGTCGTGGATGGCTGTGCATATGACCTGGACAACTACCAGACCACC
TTCCATCCAGTCGGCTCCTCTGTGACCCATCCTGATCACTATCAGAGGTTTGACATGAAGGCTTTTGCCTTTGTATCAGAAGCCCACGTG
CTCTCTAGCCTGGTCTACTTCCACTGCAGTGCCTTAATCTGTAATCGACTCTCCCCTGACTCCCCACTGTGTTCTGTGACCTGCCCTGTG
TCCTCTAGGCACAGGCGAGCCACAGGGGCCACTGAAGCAGAGAAAATGACAGTCAGCCTCCCAGGACCCATTCTCCTGTTGTCAGATGAC
TCCTCATTCAGAGGTGTCGGCTCATCTGATCTAAAAGCAAGTGGGAGCAGTGGGGAGAAGAGTAGGAGTGAAACAGGGGAGGAGGTTGGC
TCACGAGGTGCTATGGACACCAAAGGGCACAAGACTGCTGGAGATGTTGGTTCCAAAGCTGTGGCTGCTGTGGCTGCCTTTGCAGGTGTG
GTGGCAACTCTAGGCTTCATCTACTACCTGTACGAGAAAAGGACTGTGTCAAATCACTAAATGGGCTTCTAAATAAAGCAGTCAAAAT

>35587_35587_6_HADH-ZP2_HADH_chr4_108911220_ENST00000403312_ZP2_chr16_21214572_ENST00000574091_length(amino acids)=515AA_BP=102
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVT
VIGGGLMGAGIAQLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNS
SCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRNDMLLNINVESLTPPVASVKLGPFTLILQSY
PDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVGSSVTHPDHY
QRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRGVGSSDLKAS
GSSGEKSRSETGEEVGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH

--------------------------------------------------------------
>35587_35587_7_HADH-ZP2_HADH_chr4_108911220_ENST00000603302_ZP2_chr16_21214572_ENST00000219593_length(transcript)=1645nt_BP=351nt
CGTGTATACCCGCTCAACGCTGGGACGTTACAGCCAGGGCCAATGGGCAGAGCGGGACTCGAGGCCCCGCCCCCGCCTTGTGGCGTCACG
GGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCTGCCCGCCTCGCGCGTCTTCC
CTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACC
GCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGTTATCTGAA
AAATGCCTACTCCATCAGTTCTACTTAGCTTCACTCAAGCTGACCTTTCTCCTTCGGCCAGAGACAGTATCCATGGTGATCTATCCTGAG
TGTCTCTGTGAGTCACCCGTTTCTATAGTTACAGGGGAGCTGTGCACCCAGGATGGGTTTATGGACGTCGAGGTCTACAGCTACCAAACA
CAACCAGCTCTTGACCTGGGTACTCTGAGGGTGGGAAACTCATCCTGCCAGCCTGTCTTTGAGGCTCAGTCTCAGGGGCTGGTACGGTTC
CACATACCCCTGAATGGATGTGGAACGAGATATAAGTTCGAAGATGATAAAGTCGTCTATGAAAACGAAATACATGCTCTCTGGACGGAT
TTTCCTCCAAGCAAAATATCTAGAGACAGTGAGTTCAGAATGACAGTGAAGTGTTCTTATAGCAGGAATGACATGCTACTAAACATCAAC
GTTGAAAGCCTTACTCCTCCAGTGGCCTCAGTGAAGTTGGGTCCATTTACCTTGATCCTGCAAAGCTACCCAGATAATTCCTACCAACAA
CCTTATGGGGAAAACGAGTACCCTCTAGTGAGATTCCTCCGCCAACCAATTTACATGGAAGTGAGAGTCCTAAACAGGGATGACCCCAAC
ATCAAGCTGGTCTTAGATGACTGCTGGGCGACGTCCACCATGGATCCAGACTCTTTCCCCCAGTGGAACGTTGTCGTGGATGGCTGTGCA
TATGACCTGGACAACTACCAGACCACCTTCCATCCAGTCGGCTCCTCTGTGACCCATCCTGATCACTATCAGAGGTTTGACATGAAGGCT
TTTGCCTTTGTATCAGAAGCCCACGTGCTCTCTAGCCTGGTCTACTTCCACTGCAGTGCCTTAATCTGTAATCGACTCTCCCCTGACTCC
CCACTGTGTTCTGTGACCTGCCCTGTGTCCTCTAGGCACAGGCGAGCCACAGGGGCCACTGAAGCAGAGAAAATGACAGTCAGCCTCCCA
GGACCCATTCTCCTGTTGTCAGATGACTCCTCATTCAGAGGTGTCGGCTCATCTGATCTAAAAGCAAGTGGGAGCAGTGGGGAGAAGAGT
AGGAGTGAAACAGGGGAGGAGGTTGGCTCACGAGGTGCTATGGACACCAAAGGGCACAAGACTGCTGGAGATGTTGGTTCCAAAGCTGTG
GCTGCTGTGGCTGCCTTTGCAGGTGTGGTGGCAACTCTAGGCTTCATCTACTACCTGTACGAGAAAAGGACTGTGTCAAATCACTAAATG
GGCTTCTAAATAAAGCAGTCAAAAT

>35587_35587_7_HADH-ZP2_HADH_chr4_108911220_ENST00000603302_ZP2_chr16_21214572_ENST00000219593_length(amino acids)=524AA_BP=102
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVT
VIGGGLMGAGIAQLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNS
SCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLG
PFTLILQSYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVG
SSVTHPDHYQRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRG
VGSSDLKASGSSGEKSRSETGEEVGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH

--------------------------------------------------------------
>35587_35587_8_HADH-ZP2_HADH_chr4_108911220_ENST00000603302_ZP2_chr16_21214572_ENST00000574002_length(transcript)=1645nt_BP=351nt
CGTGTATACCCGCTCAACGCTGGGACGTTACAGCCAGGGCCAATGGGCAGAGCGGGACTCGAGGCCCCGCCCCCGCCTTGTGGCGTCACG
GGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCTGCCCGCCTCGCGCGTCTTCC
CTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACC
GCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGTTATCTGAA
AAATGCCTACTCCATCAGTTCTACTTAGCTTCACTCAAGCTGACCTTTCTCCTTCGGCCAGAGACAGTATCCATGGTGATCTATCCTGAG
TGTCTCTGTGAGTCACCCGTTTCTATAGTTACAGGGGAGCTGTGCACCCAGGATGGGTTTATGGACGTCGAGGTCTACAGCTACCAAACA
CAACCAGCTCTTGACCTGGGTACTCTGAGGGTGGGAAACTCATCCTGCCAGCCTGTCTTTGAGGCTCAGTCTCAGGGGCTGGTACGGTTC
CACATACCCCTGAATGGATGTGGAACGAGATATAAGTTCGAAGATGATAAAGTCGTCTATGAAAACGAAATACATGCTCTCTGGACGGAT
TTTCCTCCAAGCAAAATATCTAGAGACAGTGAGTTCAGAATGACAGTGAAGTGTTCTTATAGCAGGAATGACATGCTACTAAACATCAAC
GTTGAAAGCCTTACTCCTCCAGTGGCCTCAGTGAAGTTGGGTCCATTTACCTTGATCCTGCAAAGCTACCCAGATAATTCCTACCAACAA
CCTTATGGGGAAAACGAGTACCCTCTAGTGAGATTCCTCCGCCAACCAATTTACATGGAAGTGAGAGTCCTAAACAGGGATGACCCCAAC
ATCAAGCTGGTCTTAGATGACTGCTGGGCGACGTCCACCATGGATCCAGACTCTTTCCCCCAGTGGAACGTTGTCGTGGATGGCTGTGCA
TATGACCTGGACAACTACCAGACCACCTTCCATCCAGTCGGCTCCTCTGTGACCCATCCTGATCACTATCAGAGGTTTGACATGAAGGCT
TTTGCCTTTGTATCAGAAGCCCACGTGCTCTCTAGCCTGGTCTACTTCCACTGCAGTGCCTTAATCTGTAATCGACTCTCCCCTGACTCC
CCACTGTGTTCTGTGACCTGCCCTGTGTCCTCTAGGCACAGGCGAGCCACAGGGGCCACTGAAGCAGAGAAAATGACAGTCAGCCTCCCA
GGACCCATTCTCCTGTTGTCAGATGACTCCTCATTCAGAGGTGTCGGCTCATCTGATCTAAAAGCAAGTGGGAGCAGTGGGGAGAAGAGT
AGGAGTGAAACAGGGGAGGAGGTTGGCTCACGAGGTGCTATGGACACCAAAGGGCACAAGACTGCTGGAGATGTTGGTTCCAAAGCTGTG
GCTGCTGTGGCTGCCTTTGCAGGTGTGGTGGCAACTCTAGGCTTCATCTACTACCTGTACGAGAAAAGGACTGTGTCAAATCACTAAATG
GGCTTCTAAATAAAGCAGTCAAAAT

>35587_35587_8_HADH-ZP2_HADH_chr4_108911220_ENST00000603302_ZP2_chr16_21214572_ENST00000574002_length(amino acids)=524AA_BP=102
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVT
VIGGGLMGAGIAQLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNS
SCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLG
PFTLILQSYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVG
SSVTHPDHYQRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRG
VGSSDLKASGSSGEKSRSETGEEVGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH

--------------------------------------------------------------
>35587_35587_9_HADH-ZP2_HADH_chr4_108911220_ENST00000603302_ZP2_chr16_21214572_ENST00000574091_length(transcript)=1618nt_BP=351nt
CGTGTATACCCGCTCAACGCTGGGACGTTACAGCCAGGGCCAATGGGCAGAGCGGGACTCGAGGCCCCGCCCCCGCCTTGTGGCGTCACG
GGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCTGCCCGCCTCGCGCGTCTTCC
CTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACC
GCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGTTATCTGAA
AAATGCCTACTCCATCAGTTCTACTTAGCTTCACTCAAGCTGACCTTTCTCCTTCGGCCAGAGACAGTATCCATGGTGATCTATCCTGAG
TGTCTCTGTGAGTCACCCGTTTCTATAGTTACAGGGGAGCTGTGCACCCAGGATGGGTTTATGGACGTCGAGGTCTACAGCTACCAAACA
CAACCAGCTCTTGACCTGGGTACTCTGAGGGTGGGAAACTCATCCTGCCAGCCTGTCTTTGAGGCTCAGTCTCAGGGGCTGGTACGGTTC
CACATACCCCTGAATGGATGTGGAACGAGATATAAGTTCGAAGATGATAAAGTCGTCTATGAAAACGAAATACATGCTCTCTGGACGGAT
TTTCCTCCAAGCAAAATATCTAGAGACAGTGAGTTCAGGAATGACATGCTACTAAACATCAACGTTGAAAGCCTTACTCCTCCAGTGGCC
TCAGTGAAGTTGGGTCCATTTACCTTGATCCTGCAAAGCTACCCAGATAATTCCTACCAACAACCTTATGGGGAAAACGAGTACCCTCTA
GTGAGATTCCTCCGCCAACCAATTTACATGGAAGTGAGAGTCCTAAACAGGGATGACCCCAACATCAAGCTGGTCTTAGATGACTGCTGG
GCGACGTCCACCATGGATCCAGACTCTTTCCCCCAGTGGAACGTTGTCGTGGATGGCTGTGCATATGACCTGGACAACTACCAGACCACC
TTCCATCCAGTCGGCTCCTCTGTGACCCATCCTGATCACTATCAGAGGTTTGACATGAAGGCTTTTGCCTTTGTATCAGAAGCCCACGTG
CTCTCTAGCCTGGTCTACTTCCACTGCAGTGCCTTAATCTGTAATCGACTCTCCCCTGACTCCCCACTGTGTTCTGTGACCTGCCCTGTG
TCCTCTAGGCACAGGCGAGCCACAGGGGCCACTGAAGCAGAGAAAATGACAGTCAGCCTCCCAGGACCCATTCTCCTGTTGTCAGATGAC
TCCTCATTCAGAGGTGTCGGCTCATCTGATCTAAAAGCAAGTGGGAGCAGTGGGGAGAAGAGTAGGAGTGAAACAGGGGAGGAGGTTGGC
TCACGAGGTGCTATGGACACCAAAGGGCACAAGACTGCTGGAGATGTTGGTTCCAAAGCTGTGGCTGCTGTGGCTGCCTTTGCAGGTGTG
GTGGCAACTCTAGGCTTCATCTACTACCTGTACGAGAAAAGGACTGTGTCAAATCACTAAATGGGCTTCTAAATAAAGCAGTCAAAAT

>35587_35587_9_HADH-ZP2_HADH_chr4_108911220_ENST00000603302_ZP2_chr16_21214572_ENST00000574091_length(amino acids)=515AA_BP=102
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVT
VIGGGLMGAGIAQLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNS
SCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRNDMLLNINVESLTPPVASVKLGPFTLILQSY
PDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVGSSVTHPDHY
QRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRGVGSSDLKAS
GSSGEKSRSETGEEVGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HADH-ZP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HADH-ZP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HADH-ZP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHADHC12912303-Hydroxyacyl-CoA Dehydrogenase Deficiency7CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneHADHC1864948Hyperinsulinemic Hypoglycemia, Familial, 42CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneHADHC0028754Obesity1CTD_human
HgeneHADHC0032927Precancerous Conditions1CTD_human
HgeneHADHC0282313Condition, Preneoplastic1CTD_human
TgeneC4014291OOCYTE MATURATION DEFECT 11ORPHANET
TgeneC4540205OOCYTE MATURATION DEFECT 31ORPHANET