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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HTT-ZFYVE28 (FusionGDB2 ID:HG3064TG57732)

Fusion Gene Summary for HTT-ZFYVE28

check button Fusion gene summary
Fusion gene informationFusion gene name: HTT-ZFYVE28
Fusion gene ID: hg3064tg57732
HgeneTgene
Gene symbol

HTT

ZFYVE28

Gene ID

3064

57732

Gene namehuntingtinzinc finger FYVE-type containing 28
SynonymsHD|IT15|LOMARSLST2|LYST2|lst-2
Cytomap('HTT')('ZFYVE28')

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionhuntingtinhuntington disease proteinlateral signaling target protein 2 homologhLst2lateral signaling target-2 homologzinc finger FYVE domain-containing protein 28zinc finger, FYVE domain containing 28
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000355072, ENST00000513806, 
Fusion gene scores* DoF score13 X 13 X 5=8459 X 8 X 8=576
# samples 149
** MAII scorelog2(14/845*10)=-2.59352451422458
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/576*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HTT [Title/Abstract] AND ZFYVE28 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHTT(3184197)-ZFYVE28(2344930), # samples:2
Anticipated loss of major functional domain due to fusion event.HTT-ZFYVE28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HTT-ZFYVE28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HTT-ZFYVE28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HTT-ZFYVE28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHTT

GO:0031587

positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

12873381

HgeneHTT

GO:0043065

positive regulation of apoptotic process

17947297


check buttonFusion gene breakpoints across HTT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZFYVE28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1109-01AHTTchr4

3184197

+ZFYVE28chr4

2343342

-
ChimerDB4OVTCGA-23-1109-01AHTTchr4

3184197

+ZFYVE28chr4

2344930

-


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Fusion Gene ORF analysis for HTT-ZFYVE28

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000355072ENST00000503000HTTchr4

3184197

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000355072ENST00000505421HTTchr4

3184197

+ZFYVE28chr4

2344930

-
5CDS-5UTRENST00000355072ENST00000509171HTTchr4

3184197

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000355072ENST00000515169HTTchr4

3184197

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000355072ENST00000515312HTTchr4

3184197

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000355072ENST00000290974HTTchr4

3184197

+ZFYVE28chr4

2344930

-
5CDS-intronENST00000355072ENST00000503000HTTchr4

3184197

+ZFYVE28chr4

2344930

-
5CDS-intronENST00000355072ENST00000505421HTTchr4

3184197

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000355072ENST00000508471HTTchr4

3184197

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000355072ENST00000508471HTTchr4

3184197

+ZFYVE28chr4

2344930

-
5CDS-intronENST00000355072ENST00000509171HTTchr4

3184197

+ZFYVE28chr4

2344930

-
5CDS-intronENST00000355072ENST00000511071HTTchr4

3184197

+ZFYVE28chr4

2344930

-
5CDS-intronENST00000355072ENST00000515169HTTchr4

3184197

+ZFYVE28chr4

2344930

-
5CDS-intronENST00000355072ENST00000515312HTTchr4

3184197

+ZFYVE28chr4

2344930

-
In-frameENST00000355072ENST00000290974HTTchr4

3184197

+ZFYVE28chr4

2343342

-
In-frameENST00000355072ENST00000511071HTTchr4

3184197

+ZFYVE28chr4

2343342

-
intron-3CDSENST00000513806ENST00000290974HTTchr4

3184197

+ZFYVE28chr4

2343342

-
intron-3CDSENST00000513806ENST00000511071HTTchr4

3184197

+ZFYVE28chr4

2343342

-
intron-5UTRENST00000513806ENST00000503000HTTchr4

3184197

+ZFYVE28chr4

2343342

-
intron-5UTRENST00000513806ENST00000505421HTTchr4

3184197

+ZFYVE28chr4

2344930

-
intron-5UTRENST00000513806ENST00000509171HTTchr4

3184197

+ZFYVE28chr4

2343342

-
intron-5UTRENST00000513806ENST00000515169HTTchr4

3184197

+ZFYVE28chr4

2343342

-
intron-5UTRENST00000513806ENST00000515312HTTchr4

3184197

+ZFYVE28chr4

2343342

-
intron-intronENST00000513806ENST00000290974HTTchr4

3184197

+ZFYVE28chr4

2344930

-
intron-intronENST00000513806ENST00000503000HTTchr4

3184197

+ZFYVE28chr4

2344930

-
intron-intronENST00000513806ENST00000505421HTTchr4

3184197

+ZFYVE28chr4

2343342

-
intron-intronENST00000513806ENST00000508471HTTchr4

3184197

+ZFYVE28chr4

2343342

-
intron-intronENST00000513806ENST00000508471HTTchr4

3184197

+ZFYVE28chr4

2344930

-
intron-intronENST00000513806ENST00000509171HTTchr4

3184197

+ZFYVE28chr4

2344930

-
intron-intronENST00000513806ENST00000511071HTTchr4

3184197

+ZFYVE28chr4

2344930

-
intron-intronENST00000513806ENST00000515169HTTchr4

3184197

+ZFYVE28chr4

2344930

-
intron-intronENST00000513806ENST00000515312HTTchr4

3184197

+ZFYVE28chr4

2344930

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355072HTTchr43184197+ENST00000290974ZFYVE28chr42343342-86225011174942497
ENST00000355072HTTchr43184197+ENST00000511071ZFYVE28chr42343342-77915011174042467

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355072ENST00000290974HTTchr43184197+ZFYVE28chr42343342-0.0054559380.994544
ENST00000355072ENST00000511071HTTchr43184197+ZFYVE28chr42343342-0.0065202750.9934797

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Fusion Genomic Features for HTT-ZFYVE28


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for HTT-ZFYVE28


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:3184197/chr4:2344930)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+37671437_144016223143.0Compositional biasNote=Poly-Thr
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+376718_3816223143.0Compositional biasNote=Poly-Gln
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+376739_4916223143.0Compositional biasNote=Poly-Pro
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+376763_7816223143.0Compositional biasNote=Poly-Pro
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+3767204_24116223143.0RepeatNote=HEAT 1
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+3767246_28316223143.0RepeatNote=HEAT 2
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+3767316_36016223143.0RepeatNote=HEAT 3
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+3767802_83916223143.0RepeatNote=HEAT 4
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+3767902_94016223143.0RepeatNote=HEAT 5
TgeneZFYVE28chr4:3184197chr4:2343342ENST00000290974113817_87960888.0Zinc fingerFYVE-type
TgeneZFYVE28chr4:3184197chr4:2343342ENST0000050300017817_87960288.0Zinc fingerFYVE-type
TgeneZFYVE28chr4:3184197chr4:2343342ENST0000050917105817_87913173.0Zinc fingerFYVE-type
TgeneZFYVE28chr4:3184197chr4:2343342ENST00000511071112817_87960858.0Zinc fingerFYVE-type
TgeneZFYVE28chr4:3184197chr4:2343342ENST0000051516917817_8790164.0Zinc fingerFYVE-type
TgeneZFYVE28chr4:3184197chr4:2343342ENST00000515312113817_8790818.0Zinc fingerFYVE-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+37672341_234516223143.0Compositional biasNote=Poly-Glu
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+37672638_264316223143.0Compositional biasNote=Poly-Glu
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+37672395_240416223143.0MotifNuclear export signal


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Fusion Gene Sequence for HTT-ZFYVE28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38093_38093_1_HTT-ZFYVE28_HTT_chr4_3184197_ENST00000355072_ZFYVE28_chr4_2343342_ENST00000290974_length(transcript)=8622nt_BP=5011nt
GCTGCCGGGACGGGTCCAAGATGGACGGCCGCTCAGGTTCTGCTTTTACCTGCGGCCCAGAGCCCCATTCATTGCCCCGGTGCTGAGCGG
CGCCGCGAGTCGGCCCGAGGCCTCCGGGGACTGCCGTGCCGGGCGGGAGACCGCCATGGCGACCCTGGAAAAGCTGATGAAGGCCTTCGA
GTCCCTCAAGTCCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCCGCCACCGCC
GCCGCCGCCGCCGCCGCCTCCTCAGCTTCCTCAGCCGCCGCCGCAGGCACAGCCGCTGCTGCCTCAGCCGCAGCCGCCCCCGCCGCCGCC
CCCGCCGCCACCCGGCCCGGCTGTGGCTGAGGAGCCGCTGCACCGACCAAAGAAAGAACTTTCAGCTACCAAGAAAGACCGTGTGAATCA
TTGTCTGACAATATGTGAAAACATAGTGGCACAGTCTGTCAGAAATTCTCCAGAATTTCAGAAACTTCTGGGCATCGCTATGGAACTTTT
TCTGCTGTGCAGTGATGACGCAGAGTCAGATGTCAGGATGGTGGCTGACGAATGCCTCAACAAAGTTATCAAAGCTTTGATGGATTCTAA
TCTTCCAAGGTTACAGCTCGAGCTCTATAAGGAAATTAAAAAGAATGGTGCCCCTCGGAGTTTGCGTGCTGCCCTGTGGAGGTTTGCTGA
GCTGGCTCACCTGGTTCGGCCTCAGAAATGCAGGCCTTACCTGGTGAACCTTCTGCCGTGCCTGACTCGAACAAGCAAGAGACCCGAAGA
ATCAGTCCAGGAGACCTTGGCTGCAGCTGTTCCCAAAATTATGGCTTCTTTTGGCAATTTTGCAAATGACAATGAAATTAAGGTTTTGTT
AAAGGCCTTCATAGCGAACCTGAAGTCAAGCTCCCCCACCATTCGGCGGACAGCGGCTGGATCAGCAGTGAGCATCTGCCAGCACTCAAG
AAGGACACAATATTTCTATAGTTGGCTACTAAATGTGCTCTTAGGCTTACTCGTTCCTGTCGAGGATGAACACTCCACTCTGCTGATTCT
TGGCGTGCTGCTCACCCTGAGGTATTTGGTGCCCTTGCTGCAGCAGCAGGTCAAGGACACAAGCCTGAAAGGCAGCTTCGGAGTGACAAG
GAAAGAAATGGAAGTCTCTCCTTCTGCAGAGCAGCTTGTCCAGGTTTATGAACTGACGTTACATCATACACAGCACCAAGACCACAATGT
TGTGACCGGAGCCCTGGAGCTGTTGCAGCAGCTCTTCAGAACGCCTCCACCCGAGCTTCTGCAAACCCTGACCGCAGTCGGGGGCATTGG
GCAGCTCACCGCTGCTAAGGAGGAGTCTGGTGGCCGAAGCCGTAGTGGGAGTATTGTGGAACTTATAGCTGGAGGGGGTTCCTCATGCAG
CCCTGTCCTTTCAAGAAAACAAAAAGGCAAAGTGCTCTTAGGAGAAGAAGAAGCCTTGGAGGATGACTCTGAATCGAGATCGGATGTCAG
CAGCTCTGCCTTAACAGCCTCAGTGAAGGATGAGATCAGTGGAGAGCTGGCTGCTTCTTCAGGGGTTTCCACTCCAGGGTCAGCAGGTCA
TGACATCATCACAGAACAGCCACGGTCACAGCACACACTGCAGGCGGACTCAGTGGATCTGGCCAGCTGTGACTTGACAAGCTCTGCCAC
TGATGGGGATGAGGAGGATATCTTGAGCCACAGCTCCAGCCAGGTCAGCGCCGTCCCATCTGACCCTGCCATGGACCTGAATGATGGGAC
CCAGGCCTCGTCGCCCATCAGCGACAGCTCCCAGACCACCACCGAAGGGCCTGATTCAGCTGTTACCCCTTCAGACAGTTCTGAAATTGT
GTTAGACGGTACCGACAACCAGTATTTGGGCCTGCAGATTGGACAGCCCCAGGATGAAGATGAGGAAGCCACAGGTATTCTTCCTGATGA
AGCCTCGGAGGCCTTCAGGAACTCTTCCATGGCCCTTCAACAGGCACATTTATTGAAAAACATGAGTCACTGCAGGCAGCCTTCTGACAG
CAGTGTTGATAAATTTGTGTTGAGAGATGAAGCTACTGAACCGGGTGATCAAGAAAACAAGCCTTGCCGCATCAAAGGTGACATTGGACA
GTCCACTGATGATGACTCTGCACCTCTTGTCCATTGTGTCCGCCTTTTATCTGCTTCGTTTTTGCTAACAGGGGGAAAAAATGTGCTGGT
TCCGGACAGGGATGTGAGGGTCAGCGTGAAGGCCCTGGCCCTCAGCTGTGTGGGAGCAGCTGTGGCCCTCCACCCGGAATCTTTCTTCAG
CAAACTCTATAAAGTTCCTCTTGACACCACGGAATACCCTGAGGAACAGTATGTCTCAGACATCTTGAACTACATCGATCATGGAGACCC
ACAGGTTCGAGGAGCCACTGCCATTCTCTGTGGGACCCTCATCTGCTCCATCCTCAGCAGGTCCCGCTTCCACGTGGGAGATTGGATGGG
CACCATTAGAACCCTCACAGGAAATACATTTTCTTTGGCGGATTGCATTCCTTTGCTGCGGAAAACACTGAAGGATGAGTCTTCTGTTAC
TTGCAAGTTAGCTTGTACAGCTGTGAGGAACTGTGTCATGAGTCTCTGCAGCAGCAGCTACAGTGAGTTAGGACTGCAGCTGATCATCGA
TGTGCTGACTCTGAGGAACAGTTCCTATTGGCTGGTGAGGACAGAGCTTCTGGAAACCCTTGCAGAGATTGACTTCAGGCTGGTGAGCTT
TTTGGAGGCAAAAGCAGAAAACTTACACAGAGGGGCTCATCATTATACAGGGCTTTTAAAACTGCAAGAACGAGTGCTCAATAATGTTGT
CATCCATTTGCTTGGAGATGAAGACCCCAGGGTGCGACATGTTGCCGCAGCATCACTAATTAGGCTTGTCCCAAAGCTGTTTTATAAATG
TGACCAAGGACAAGCTGATCCAGTAGTGGCCGTGGCAAGAGATCAAAGCAGTGTTTACCTGAAACTTCTCATGCATGAGACGCAGCCTCC
ATCTCATTTCTCCGTCAGCACAATAACCAGAATATATAGAGGCTATAACCTACTACCAAGCATAACAGACGTCACTATGGAAAATAACCT
TTCAAGAGTTATTGCAGCAGTTTCTCATGAACTAATCACATCAACCACCAGAGCACTCACATTTGGATGCTGTGAAGCTTTGTGTCTTCT
TTCCACTGCCTTCCCAGTTTGCATTTGGAGTTTAGGTTGGCACTGTGGAGTGCCTCCACTGAGTGCCTCAGATGAGTCTAGGAAGAGCTG
TACCGTTGGGATGGCCACAATGATTCTGACCCTGCTCTCGTCAGCTTGGTTCCCATTGGATCTCTCAGCCCATCAAGATGCTTTGATTTT
GGCCGGAAACTTGCTTGCAGCCAGTGCTCCCAAATCTCTGAGAAGTTCATGGGCCTCTGAAGAAGAAGCCAACCCAGCAGCCACCAAGCA
AGAGGAGGTCTGGCCAGCCCTGGGGGACCGGGCCCTGGTGCCCATGGTGGAGCAGCTCTTCTCTCACCTGCTGAAGGTGATTAACATTTG
TGCCCACGTCCTGGATGACGTGGCTCCTGGACCCGCAATAAAGGCAGCCTTGCCTTCTCTAACAAACCCCCCTTCTCTAAGTCCCATCCG
ACGAAAGGGGAAGGAGAAAGAACCAGGAGAACAAGCATCTGTACCGTTGAGTCCCAAGAAAGGCAGTGAGGCCAGTGCAGCTTCTAGACA
ATCTGATACCTCAGGTCCTGTTACAACAAGTAAATCCTCATCACTGGGGAGTTTCTATCATCTTCCTTCATACCTCAAACTGCATGATGT
CCTGAAAGCTACACACGCTAACTACAAGGTCACGCTGGATCTTCAGAACAGCACGGAAAAGTTTGGAGGGTTTCTCCGCTCAGCCTTGGA
TGTTCTTTCTCAGATACTAGAGCTGGCCACACTGCAGGACATTGGGAAGTGTGTTGAAGAGATCCTAGGATACCTGAAATCCTGCTTTAG
TCGAGAACCAATGATGGCAACTGTTTGTGTTCAACAATTGTTGAAGACTCTCTTTGGCACAAACTTGGCCTCCCAGTTTGATGGCTTATC
TTCCAACCCCAGCAAGTCACAAGGCCGAGCACAGCGCCTTGGCTCCTCCAGTGTGAGGCCAGGCTTGTACCACTACTGCTTCATGGCCCC
GTACACCCACTTCACCCAGGCCCTCGCTGACGCCAGCCTGAGGAACATGGTGCAGGCGGAGCAGGAGAACGACACCTCGGGATGGTTTGA
TGTCCTCCAGAAAGTGTCTACCCAGTTGAAGACAAACCTCACGAGTGTCACAAAGAACCGTGCAGATAAGAATGCTATTCATAATCACAT
TCGTTTGTTTGAACCTCTTGTTATAAAAGCTTTAAAACAGTACACGACTACAACATGTGTGCAGTTACAGAAGCAGGTTTTAGATTTGCT
GGCGCAGCTGGTTCAGTTACGGGTTAATTACTGTCTTCTGGATTCAGATCAGGTGTTTATTGGCTTTGTATTGAAACAGTTTGAATACAT
TGAAGTGGGCCAGTTCAGGGAATCAGAGGCAATCATTCCAAACATCTTTTTCTTCTTGGTATTACTATCTTATGAACGCTATCATTCAAA
ACAGATCATTGGAATTCCTAAAATCATTCAGCTCTGTGATGGCATCATGGCCAGTGGAAGGAAGGCTGTGACACATGCCATACCGGCTCT
GCAGCCCATAGTCCACGACCTCTTTGTATTAAGAGGAACAAATAAAGCTGATGCAGGAAAAGAGCTTGAAACCCAAAAAGAGGTGGTGGT
GTCAATGTTACTGAGACTCATCCAGTACCATCAGGTGTTGGAGATGTTCATTCTTGTCCTGCAGCAGTGCCACAAGGAGAATGAAGACAA
GTGGAAGCGACTGTCTCGACAGATAGCTGACATCATCCTCCCAATGTTAGCCAAACAGCAGGACAATGTGTTGAACATCATTAACCAGAT
CATGGATGAGTGCATCCCCCAGGACCGCGCCCCCAGAGATTTCTGCGTCAAGTTCCCTGAGGAGATCCGGCACGACAACCTGGCCGGCCA
GCTGTGGTTCGGTGCCGAGTGCCTGGCCGCCGGCTCCATCATCATGAACCGGGAGCTGGAGAGCATGGCCATGCGCCCGCTGGCCAAGGA
GCTGACGCGCAGCCTGGAGGACGTGCGGGGCGCCCTCCGTGACCAGGCGCTGCGGGACCTGAACACCTACACAGAGAAGATGAGGGAAGC
GCTGAGGCACTTCGACGTCCTGTTCGCAGAGTTTGAGCTCAGCTACGTCTCGGCCATGGTGCCTGTGAAGTCCCCCAGGGAGTACTACGT
GCAGCAGGAGGTCATCGTGCTCTTCTGCGAGACGGTGGAGAGGGCCCTGGACTTCGGGTACCTGACTCAGGACATGATTGATGACTACGA
GCCGGCCCTCATGTTCAGCATCCCCAGGCTGGCCATCGTGTGTGGCCTCGTGGTCTATGCGGACGGACCTCTGAACTTGGACCGCAAGGT
GGAAGACATGTCCGAGCTGTTCCGGCCCTTCCACACGTTGCTGCGGAAAATAAGGGATTTGCTGCAGACGCTGACGGAGGAGGAGCTGCA
CACGCTGGAACGGAACCTCTGCATTTCCCAAGACGTGGAGTTCCCCATCCGCGCAGACGTGCAGGGACCCGCTGCCCTGGCGCCTGCCCT
CTCTGCCCCTCTCCCCCCTGAGGGGCCACTCTCAGCTAAGGCCAAAGACCCGGATGCAGAGCTGGCCTGCTCCATGCAGTACGACGACCA
GGAGCTGGAGCAGCTCAGCCGCATGGTCCACAGGGCGGGGGACGAGATGTCCTCTTTGCTTTCACCGCCCATTGCCTGCCAGTCCCCAGC
TCACAGGCCAGGAGCGGAGGGCAGCCCAGGCGGGGAGGCCTCTCCAGGTAGACCGCGCCTGCGGTCAGGCAGTGACGAGGAGGAGCGCGT
GTTCTTCATGGATGACGTGGAGGGGACGGCAGAAGCCCTGGCCAGGCCCGAGTCCCCAGCTGGCCCATTTGGGTGGGCAGGCAGTACCTG
GGCCGACCCCCAGGAGAAAGGGCAGGGTGGGCCAGGCGGAGCGGCGGGGATCAGCTTGCCCGCCTCGGAAAAGGAGGAGGACTTGAGCAA
CAACAATCTCGAGGCCGAGGGCACAGATGGGGCCAGCCTCGCGGGCACCAGCTCCTGCAGCTGCCTGGACTCGCGGCTGCACCTGGACGG
CTGGGAGGTGGGTGCGGATGACGCAGAGACGGCTGAGATGATCGCCCACCGGACAGGGGGCATGAAGCTCTCAGCCACGGTCATCTTCAA
CCCCAAATCGCCCACTTCCCTGGACTCTGCGGTCGCCACCCAGGAGGCCGCCTCGGAGCCCGTGGCCGAGGGGATGGATGGCGGCCCCCA
CAAGCTTAGCACTGGGGCCACCAACTGCCTTCTGCATTCCTGCGTGTGCTGTGGGAGCTGCGGGGACAGCAGGGAGGACGTGGTGGAGCG
TCTGCGGGAGAAGTGCAGCCCGGGAGGCGTCATTGGTGCCTCGTACGCTGCCGGCTTAGCCAAGGCCAGCGACAGGGCCCCTGAGAGACA
GGAGGAGGCGCCCCCACCCTCAGAAGATGCCTCCAACGGGCGGGAGCCCAAAGCCCCCACTTCCGACAAGTGCCTGCCTCACACCTCAGG
TTCCCAGGTGGACACAGCGAGTGGGCTGCAAGGAGAGGCTGGGGTTGCAGGTCAGCAGGAGCCAGAGGCCAGAGAGCTGCATGCTGGGAG
CCCCTCGGCTCACGAGGCGCCTCAGGCCCTGTCGGGCTCCAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGCCAGAGGC
GGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCCACCGCCT
GTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTGAGGTCAT
GGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTGCACTGTG
CCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACGAGGCCTG
TGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCTCGCGCTG
CTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCACGCCCTT
CTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACCCCCAGGAAGGTGGGGCCACGCTG
CAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGCATCCAGAGCCTCTGTCCTGCCCA
CGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCAGGGGACCCGGAGGAGCCTGGTGG
CTGCCTCAGGGCAGGGTGCCTGGCGGAGAAGGCCTGGGCCCTCCCACTGGTCCCTCGGAGATCTGCTGGGGCTATGGGAATCGGGGCGGG
TGATGGAGGTGGACAAGAGTGGGGCCACTCTGCGCCTCTGCTGTTGCGGTGAATCTGGAAGCCGGAGCAAGGGCCACTCCACAGGCTCTT
TGGCACAGCAGGGCTCCCTATGTGCCTCCCAAACGTCAAATGCAGGCTACCCATTCTCCCCATCAGCTGCCCACCTCGTTCCCCAGCCCT
CACCCCTCACCCCTCACCATCCTTCCTCAGGACTTGGCTAAACAACATGCATCTCATTTCTTCTTGGAGTGGGGAGATGCGGGAAGCTGA
CCCAGTGGTCCTCTAGGCAGGCAGGGTGCTCCTGGTGTCTGCCCACCACTGTCCCCTTGCTGATGGCATGGGGGTCCGACCAGGCACTGA
CACCGCAGGCAGAGGTTGCTCGGGGCCTTGGGTCGGGTTTACCAATCAGCCAGGACGCCCGGGGCCACCAGCTCAGCTACCACTTCCCCT
TCCCTCTGCACCCTCTGGAACCCTGGCCCAATTCCTCAGACCCCAGAGTGGCCTGGGACCCAAGCTGCCGCAGCTGAGTGGCCCCAGCGG
ACACCTCCTCAGGCTTAAATCTCAGGCTTCACATTGCAATGACGATTGCAGTTTTATTTTTGGAGATGACACACCTACTGCTTCTTTTCT
AGGATAAATCTAATTACTGTTTACTGGTGGAGTACATATGCATAGAAACGGCTTCTGTCGGGGGGAGAGTATATAATGGAGGAAATATTA
TGTATTGAGATTATATTTATTTTCTAAATGCTGTAATTTGAAGCCATTTCCATAAATCTATTTAAGGATTGC

>38093_38093_1_HTT-ZFYVE28_HTT_chr4_3184197_ENST00000355072_ZFYVE28_chr4_2343342_ENST00000290974_length(amino acids)=2497AA_BP=1669
LPGRVQDGRPLRFCFYLRPRAPFIAPVLSGAASRPEASGDCRAGRETAMATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPP
PPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELF
LLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEE
SVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLIL
GVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIG
QLTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSAGH
DIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAVPSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIV
LDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMALQQAHLLKNMSHCRQPSDSSVDKFVLRDEATEPGDQENKPCRIKGDIGQ
STDDDSAPLVHCVRLLSASFLLTGGKNVLVPDRDVRVSVKALALSCVGAAVALHPESFFSKLYKVPLDTTEYPEEQYVSDILNYIDHGDP
QVRGATAILCGTLICSILSRSRFHVGDWMGTIRTLTGNTFSLADCIPLLRKTLKDESSVTCKLACTAVRNCVMSLCSSSYSELGLQLIID
VLTLRNSSYWLVRTELLETLAEIDFRLVSFLEAKAENLHRGAHHYTGLLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPKLFYKC
DQGQADPVVAVARDQSSVYLKLLMHETQPPSHFSVSTITRIYRGYNLLPSITDVTMENNLSRVIAAVSHELITSTTRALTFGCCEALCLL
STAFPVCIWSLGWHCGVPPLSASDESRKSCTVGMATMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRSSWASEEEANPAATKQ
EEVWPALGDRALVPMVEQLFSHLLKVINICAHVLDDVAPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQASVPLSPKKGSEASAASRQ
SDTSGPVTTSKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFS
REPMMATVCVQQLLKTLFGTNLASQFDGLSSNPSKSQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQAEQENDTSGWFD
VLQKVSTQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTCVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYI
EVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVV
SMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQIADIILPMLAKQQDNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQ
LWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYV
QQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELH
TLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPA
HRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSN
NNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPH
KLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSG
SQVDTASGLQGEAGVAGQQEPEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRL
FVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEAC
GFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL

--------------------------------------------------------------
>38093_38093_2_HTT-ZFYVE28_HTT_chr4_3184197_ENST00000355072_ZFYVE28_chr4_2343342_ENST00000511071_length(transcript)=7791nt_BP=5011nt
GCTGCCGGGACGGGTCCAAGATGGACGGCCGCTCAGGTTCTGCTTTTACCTGCGGCCCAGAGCCCCATTCATTGCCCCGGTGCTGAGCGG
CGCCGCGAGTCGGCCCGAGGCCTCCGGGGACTGCCGTGCCGGGCGGGAGACCGCCATGGCGACCCTGGAAAAGCTGATGAAGGCCTTCGA
GTCCCTCAAGTCCTTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCCGCCACCGCC
GCCGCCGCCGCCGCCGCCTCCTCAGCTTCCTCAGCCGCCGCCGCAGGCACAGCCGCTGCTGCCTCAGCCGCAGCCGCCCCCGCCGCCGCC
CCCGCCGCCACCCGGCCCGGCTGTGGCTGAGGAGCCGCTGCACCGACCAAAGAAAGAACTTTCAGCTACCAAGAAAGACCGTGTGAATCA
TTGTCTGACAATATGTGAAAACATAGTGGCACAGTCTGTCAGAAATTCTCCAGAATTTCAGAAACTTCTGGGCATCGCTATGGAACTTTT
TCTGCTGTGCAGTGATGACGCAGAGTCAGATGTCAGGATGGTGGCTGACGAATGCCTCAACAAAGTTATCAAAGCTTTGATGGATTCTAA
TCTTCCAAGGTTACAGCTCGAGCTCTATAAGGAAATTAAAAAGAATGGTGCCCCTCGGAGTTTGCGTGCTGCCCTGTGGAGGTTTGCTGA
GCTGGCTCACCTGGTTCGGCCTCAGAAATGCAGGCCTTACCTGGTGAACCTTCTGCCGTGCCTGACTCGAACAAGCAAGAGACCCGAAGA
ATCAGTCCAGGAGACCTTGGCTGCAGCTGTTCCCAAAATTATGGCTTCTTTTGGCAATTTTGCAAATGACAATGAAATTAAGGTTTTGTT
AAAGGCCTTCATAGCGAACCTGAAGTCAAGCTCCCCCACCATTCGGCGGACAGCGGCTGGATCAGCAGTGAGCATCTGCCAGCACTCAAG
AAGGACACAATATTTCTATAGTTGGCTACTAAATGTGCTCTTAGGCTTACTCGTTCCTGTCGAGGATGAACACTCCACTCTGCTGATTCT
TGGCGTGCTGCTCACCCTGAGGTATTTGGTGCCCTTGCTGCAGCAGCAGGTCAAGGACACAAGCCTGAAAGGCAGCTTCGGAGTGACAAG
GAAAGAAATGGAAGTCTCTCCTTCTGCAGAGCAGCTTGTCCAGGTTTATGAACTGACGTTACATCATACACAGCACCAAGACCACAATGT
TGTGACCGGAGCCCTGGAGCTGTTGCAGCAGCTCTTCAGAACGCCTCCACCCGAGCTTCTGCAAACCCTGACCGCAGTCGGGGGCATTGG
GCAGCTCACCGCTGCTAAGGAGGAGTCTGGTGGCCGAAGCCGTAGTGGGAGTATTGTGGAACTTATAGCTGGAGGGGGTTCCTCATGCAG
CCCTGTCCTTTCAAGAAAACAAAAAGGCAAAGTGCTCTTAGGAGAAGAAGAAGCCTTGGAGGATGACTCTGAATCGAGATCGGATGTCAG
CAGCTCTGCCTTAACAGCCTCAGTGAAGGATGAGATCAGTGGAGAGCTGGCTGCTTCTTCAGGGGTTTCCACTCCAGGGTCAGCAGGTCA
TGACATCATCACAGAACAGCCACGGTCACAGCACACACTGCAGGCGGACTCAGTGGATCTGGCCAGCTGTGACTTGACAAGCTCTGCCAC
TGATGGGGATGAGGAGGATATCTTGAGCCACAGCTCCAGCCAGGTCAGCGCCGTCCCATCTGACCCTGCCATGGACCTGAATGATGGGAC
CCAGGCCTCGTCGCCCATCAGCGACAGCTCCCAGACCACCACCGAAGGGCCTGATTCAGCTGTTACCCCTTCAGACAGTTCTGAAATTGT
GTTAGACGGTACCGACAACCAGTATTTGGGCCTGCAGATTGGACAGCCCCAGGATGAAGATGAGGAAGCCACAGGTATTCTTCCTGATGA
AGCCTCGGAGGCCTTCAGGAACTCTTCCATGGCCCTTCAACAGGCACATTTATTGAAAAACATGAGTCACTGCAGGCAGCCTTCTGACAG
CAGTGTTGATAAATTTGTGTTGAGAGATGAAGCTACTGAACCGGGTGATCAAGAAAACAAGCCTTGCCGCATCAAAGGTGACATTGGACA
GTCCACTGATGATGACTCTGCACCTCTTGTCCATTGTGTCCGCCTTTTATCTGCTTCGTTTTTGCTAACAGGGGGAAAAAATGTGCTGGT
TCCGGACAGGGATGTGAGGGTCAGCGTGAAGGCCCTGGCCCTCAGCTGTGTGGGAGCAGCTGTGGCCCTCCACCCGGAATCTTTCTTCAG
CAAACTCTATAAAGTTCCTCTTGACACCACGGAATACCCTGAGGAACAGTATGTCTCAGACATCTTGAACTACATCGATCATGGAGACCC
ACAGGTTCGAGGAGCCACTGCCATTCTCTGTGGGACCCTCATCTGCTCCATCCTCAGCAGGTCCCGCTTCCACGTGGGAGATTGGATGGG
CACCATTAGAACCCTCACAGGAAATACATTTTCTTTGGCGGATTGCATTCCTTTGCTGCGGAAAACACTGAAGGATGAGTCTTCTGTTAC
TTGCAAGTTAGCTTGTACAGCTGTGAGGAACTGTGTCATGAGTCTCTGCAGCAGCAGCTACAGTGAGTTAGGACTGCAGCTGATCATCGA
TGTGCTGACTCTGAGGAACAGTTCCTATTGGCTGGTGAGGACAGAGCTTCTGGAAACCCTTGCAGAGATTGACTTCAGGCTGGTGAGCTT
TTTGGAGGCAAAAGCAGAAAACTTACACAGAGGGGCTCATCATTATACAGGGCTTTTAAAACTGCAAGAACGAGTGCTCAATAATGTTGT
CATCCATTTGCTTGGAGATGAAGACCCCAGGGTGCGACATGTTGCCGCAGCATCACTAATTAGGCTTGTCCCAAAGCTGTTTTATAAATG
TGACCAAGGACAAGCTGATCCAGTAGTGGCCGTGGCAAGAGATCAAAGCAGTGTTTACCTGAAACTTCTCATGCATGAGACGCAGCCTCC
ATCTCATTTCTCCGTCAGCACAATAACCAGAATATATAGAGGCTATAACCTACTACCAAGCATAACAGACGTCACTATGGAAAATAACCT
TTCAAGAGTTATTGCAGCAGTTTCTCATGAACTAATCACATCAACCACCAGAGCACTCACATTTGGATGCTGTGAAGCTTTGTGTCTTCT
TTCCACTGCCTTCCCAGTTTGCATTTGGAGTTTAGGTTGGCACTGTGGAGTGCCTCCACTGAGTGCCTCAGATGAGTCTAGGAAGAGCTG
TACCGTTGGGATGGCCACAATGATTCTGACCCTGCTCTCGTCAGCTTGGTTCCCATTGGATCTCTCAGCCCATCAAGATGCTTTGATTTT
GGCCGGAAACTTGCTTGCAGCCAGTGCTCCCAAATCTCTGAGAAGTTCATGGGCCTCTGAAGAAGAAGCCAACCCAGCAGCCACCAAGCA
AGAGGAGGTCTGGCCAGCCCTGGGGGACCGGGCCCTGGTGCCCATGGTGGAGCAGCTCTTCTCTCACCTGCTGAAGGTGATTAACATTTG
TGCCCACGTCCTGGATGACGTGGCTCCTGGACCCGCAATAAAGGCAGCCTTGCCTTCTCTAACAAACCCCCCTTCTCTAAGTCCCATCCG
ACGAAAGGGGAAGGAGAAAGAACCAGGAGAACAAGCATCTGTACCGTTGAGTCCCAAGAAAGGCAGTGAGGCCAGTGCAGCTTCTAGACA
ATCTGATACCTCAGGTCCTGTTACAACAAGTAAATCCTCATCACTGGGGAGTTTCTATCATCTTCCTTCATACCTCAAACTGCATGATGT
CCTGAAAGCTACACACGCTAACTACAAGGTCACGCTGGATCTTCAGAACAGCACGGAAAAGTTTGGAGGGTTTCTCCGCTCAGCCTTGGA
TGTTCTTTCTCAGATACTAGAGCTGGCCACACTGCAGGACATTGGGAAGTGTGTTGAAGAGATCCTAGGATACCTGAAATCCTGCTTTAG
TCGAGAACCAATGATGGCAACTGTTTGTGTTCAACAATTGTTGAAGACTCTCTTTGGCACAAACTTGGCCTCCCAGTTTGATGGCTTATC
TTCCAACCCCAGCAAGTCACAAGGCCGAGCACAGCGCCTTGGCTCCTCCAGTGTGAGGCCAGGCTTGTACCACTACTGCTTCATGGCCCC
GTACACCCACTTCACCCAGGCCCTCGCTGACGCCAGCCTGAGGAACATGGTGCAGGCGGAGCAGGAGAACGACACCTCGGGATGGTTTGA
TGTCCTCCAGAAAGTGTCTACCCAGTTGAAGACAAACCTCACGAGTGTCACAAAGAACCGTGCAGATAAGAATGCTATTCATAATCACAT
TCGTTTGTTTGAACCTCTTGTTATAAAAGCTTTAAAACAGTACACGACTACAACATGTGTGCAGTTACAGAAGCAGGTTTTAGATTTGCT
GGCGCAGCTGGTTCAGTTACGGGTTAATTACTGTCTTCTGGATTCAGATCAGGTGTTTATTGGCTTTGTATTGAAACAGTTTGAATACAT
TGAAGTGGGCCAGTTCAGGGAATCAGAGGCAATCATTCCAAACATCTTTTTCTTCTTGGTATTACTATCTTATGAACGCTATCATTCAAA
ACAGATCATTGGAATTCCTAAAATCATTCAGCTCTGTGATGGCATCATGGCCAGTGGAAGGAAGGCTGTGACACATGCCATACCGGCTCT
GCAGCCCATAGTCCACGACCTCTTTGTATTAAGAGGAACAAATAAAGCTGATGCAGGAAAAGAGCTTGAAACCCAAAAAGAGGTGGTGGT
GTCAATGTTACTGAGACTCATCCAGTACCATCAGGTGTTGGAGATGTTCATTCTTGTCCTGCAGCAGTGCCACAAGGAGAATGAAGACAA
GTGGAAGCGACTGTCTCGACAGATAGCTGACATCATCCTCCCAATGTTAGCCAAACAGCAGGACAATGTGTTGAACATCATTAACCAGAT
CATGGATGAGTGCATCCCCCAGGACCGCGCCCCCAGAGATTTCTGCGTCAAGTTCCCTGAGGAGATCCGGCACGACAACCTGGCCGGCCA
GCTGTGGTTCGGTGCCGAGTGCCTGGCCGCCGGCTCCATCATCATGAACCGGGAGCTGGAGAGCATGGCCATGCGCCCGCTGGCCAAGGA
GCTGACGCGCAGCCTGGAGGACGTGCGGGGCGCCCTCCGTGACCAGGCGCTGCGGGACCTGAACACCTACACAGAGAAGATGAGGGAAGC
GCTGAGGCACTTCGACGTCCTGTTCGCAGAGTTTGAGCTCAGCTACGTCTCGGCCATGGTGCCTGTGAAGTCCCCCAGGGAGTACTACGT
GCAGCAGGAGGTCATCGTGCTCTTCTGCGAGACGGTGGAGAGTGGCCTCGTGGTCTATGCGGACGGACCTCTGAACTTGGACCGCAAGGT
GGAAGACATGTCCGAGCTGTTCCGGCCCTTCCACACGTTGCTGCGGAAAATAAGGGATTTGCTGCAGACGCTGACGGAGGAGGAGCTGCA
CACGCTGGAACGGAACCTCTGCATTTCCCAAGACGTGGAGTTCCCCATCCGCGCAGACGTGCAGGGACCCGCTGCCCTGGCGCCTGCCCT
CTCTGCCCCTCTCCCCCCTGAGGGGCCACTCTCAGCTAAGGCCAAAGACCCGGATGCAGAGCTGGCCTGCTCCATGCAGTACGACGACCA
GGAGCTGGAGCAGCTCAGCCGCATGGTCCACAGGGCGGGGGACGAGATGTCCTCTTTGCTTTCACCGCCCATTGCCTGCCAGTCCCCAGC
TCACAGGCCAGGAGCGGAGGGCAGCCCAGGCGGGGAGGCCTCTCCAGGTAGACCGCGCCTGCGGTCAGGCAGTGACGAGGAGGAGCGCGT
GTTCTTCATGGATGACGTGGAGGGGACGGCAGAAGCCCTGGCCAGGCCCGAGTCCCCAGCTGGCCCATTTGGGTGGGCAGGCAGTACCTG
GGCCGACCCCCAGGAGAAAGGGCAGGGTGGGCCAGGCGGAGCGGCGGGGATCAGCTTGCCCGCCTCGGAAAAGGAGGAGGACTTGAGCAA
CAACAATCTCGAGGCCGAGGGCACAGATGGGGCCAGCCTCGCGGGCACCAGCTCCTGCAGCTGCCTGGACTCGCGGCTGCACCTGGACGG
CTGGGAGGTGGGTGCGGATGACGCAGAGACGGCTGAGATGATCGCCCACCGGACAGGGGGCATGAAGCTCTCAGCCACGGTCATCTTCAA
CCCCAAATCGCCCACTTCCCTGGACTCTGCGGTCGCCACCCAGGAGGCCGCCTCGGAGCCCGTGGCCGAGGGGATGGATGGCGGCCCCCA
CAAGCTTAGCACTGGGGCCACCAACTGCCTTCTGCATTCCTGCGTGTGCTGTGGGAGCTGCGGGGACAGCAGGGAGGACGTGGTGGAGCG
TCTGCGGGAGAAGTGCAGCCCGGGAGGCGTCATTGGTGCCTCGTACGCTGCCGGCTTAGCCAAGGCCAGCGACAGGGCCCCTGAGAGACA
GGAGGAGGCGCCCCCACCCTCAGAAGATGCCTCCAACGGGCGGGAGCCCAAAGCCCCCACTTCCGACAAGTGCCTGCCTCACACCTCAGG
TTCCCAGGTGGACACAGCGAGTGGGCTGCAAGGAGAGGCTGGGGTTGCAGGTCAGCAGGAGCCAGAGGCCAGAGAGCTGCATGCTGGGAG
CCCCTCGGCTCACGAGGCGCCTCAGGCCCTGTCGGGCTCCAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGCCAGAGGC
GGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCCACCGCCT
GTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTGAGGTCAT
GGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTGCACTGTG
CCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACGAGGCCTG
TGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCTCGCGCTG
CTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCACGCCCTT
CTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACCCCCAGGAAGGTGGGGCCACGCTG
CAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGCATCCAGAGCCTCTGTCCTGCCCA
CGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCAGGGGACCCGGAGGAGCCTGGTGG
CTGCCTCAGGGCAGGGTGCCTGGCGGAGAAGGCCTGGGCCCTCCCACTGGTCCCTCGGAGATCTGCTGGGGCTATGGGAATCGGGGCGGG
TGATGGAGGTGGACAAGAGTGGGGCCACTCTGCGCCTCTGCTGTTGCGGTG

>38093_38093_2_HTT-ZFYVE28_HTT_chr4_3184197_ENST00000355072_ZFYVE28_chr4_2343342_ENST00000511071_length(amino acids)=2467AA_BP=1669
LPGRVQDGRPLRFCFYLRPRAPFIAPVLSGAASRPEASGDCRAGRETAMATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPP
PPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELF
LLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEE
SVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLIL
GVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIG
QLTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSAGH
DIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAVPSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIV
LDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMALQQAHLLKNMSHCRQPSDSSVDKFVLRDEATEPGDQENKPCRIKGDIGQ
STDDDSAPLVHCVRLLSASFLLTGGKNVLVPDRDVRVSVKALALSCVGAAVALHPESFFSKLYKVPLDTTEYPEEQYVSDILNYIDHGDP
QVRGATAILCGTLICSILSRSRFHVGDWMGTIRTLTGNTFSLADCIPLLRKTLKDESSVTCKLACTAVRNCVMSLCSSSYSELGLQLIID
VLTLRNSSYWLVRTELLETLAEIDFRLVSFLEAKAENLHRGAHHYTGLLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPKLFYKC
DQGQADPVVAVARDQSSVYLKLLMHETQPPSHFSVSTITRIYRGYNLLPSITDVTMENNLSRVIAAVSHELITSTTRALTFGCCEALCLL
STAFPVCIWSLGWHCGVPPLSASDESRKSCTVGMATMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRSSWASEEEANPAATKQ
EEVWPALGDRALVPMVEQLFSHLLKVINICAHVLDDVAPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQASVPLSPKKGSEASAASRQ
SDTSGPVTTSKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFS
REPMMATVCVQQLLKTLFGTNLASQFDGLSSNPSKSQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQAEQENDTSGWFD
VLQKVSTQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTCVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYI
EVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVV
SMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQIADIILPMLAKQQDNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQ
LWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYV
QQEVIVLFCETVESGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPAL
SAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERV
FFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDSRLHLDG
WEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVER
LREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGS
PSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVM
ATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRC
SSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HTT-ZFYVE28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneHTTchr4:3184197chr4:2343342ENST00000355072+3767491_5021622.03143.0ZDHHC17


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HTT-ZFYVE28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HTT-ZFYVE28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHTTC0020179Huntington Disease12CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneHTTC0751208Juvenile Huntington Disease12CTD_human;ORPHANET
HgeneHTTC0393574Huntington Disease, Late Onset11CTD_human
HgeneHTTC0751207Akinetic-Rigid Variant of Huntington Disease11CTD_human
HgeneHTTC0011570Mental Depression4PSYGENET
HgeneHTTC0011581Depressive disorder4PSYGENET
HgeneHTTC0525045Mood Disorders2PSYGENET
HgeneHTTC4479491LOPES-MACIEL-RODAN SYNDROME2GENOMICS_ENGLAND;UNIPROT
HgeneHTTC0006635Cadmium poisoning1CTD_human
HgeneHTTC0026650Movement Disorders1CTD_human
HgeneHTTC0266487Etat Marbre1CTD_human
HgeneHTTC0677050Manganese Poisoning1CTD_human
HgeneHTTC3714756Intellectual Disability1GENOMICS_ENGLAND