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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANXA4-SMU1 (FusionGDB2 ID:HG307TG55234)

Fusion Gene Summary for ANXA4-SMU1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANXA4-SMU1
Fusion gene ID: hg307tg55234
HgeneTgene
Gene symbol

ANXA4

SMU1

Gene ID

307

55234

Gene nameannexin A4SMU1 DNA replication regulator and spliceosomal factor
SynonymsANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36BWD|SMU-1|fSAP57
Cytomap('ANXA4')('SMU1')

2p13.3

9p21.1

Type of geneprotein-codingprotein-coding
Descriptionannexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-induWD40 repeat-containing protein SMU1DNA replication regulator and spliceosomal factorbrain-enriched WD-repeat proteinfunctional spliceosome-associated protein 57smu-1 suppressor of mec-8 and unc-52 homologsmu-1 suppressor of mec-8 and unc-52 protein h
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000394295, ENST00000409920, 
ENST00000536030, ENST00000418066, 
Fusion gene scores* DoF score14 X 12 X 7=11764 X 4 X 4=64
# samples 164
** MAII scorelog2(16/1176*10)=-2.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANXA4 [Title/Abstract] AND SMU1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANXA4(70047953)-SMU1(33053288), # samples:1
Anticipated loss of major functional domain due to fusion event.ANXA4-SMU1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANXA4-SMU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANXA4

GO:0006357

regulation of transcription by RNA polymerase II

20237821

HgeneANXA4

GO:0032088

negative regulation of NF-kappaB transcription factor activity

20237821

TgeneSMU1

GO:0000398

mRNA splicing, via spliceosome

28781166


check buttonFusion gene breakpoints across ANXA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SMU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8058-01AANXA4chr2

70047953

+SMU1chr9

33053288

-


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Fusion Gene ORF analysis for ANXA4-SMU1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394295ENST00000397149ANXA4chr2

70047953

+SMU1chr9

33053288

-
In-frameENST00000394295ENST00000536631ANXA4chr2

70047953

+SMU1chr9

33053288

-
In-frameENST00000409920ENST00000397149ANXA4chr2

70047953

+SMU1chr9

33053288

-
In-frameENST00000409920ENST00000536631ANXA4chr2

70047953

+SMU1chr9

33053288

-
In-frameENST00000536030ENST00000397149ANXA4chr2

70047953

+SMU1chr9

33053288

-
In-frameENST00000536030ENST00000536631ANXA4chr2

70047953

+SMU1chr9

33053288

-
intron-3CDSENST00000418066ENST00000397149ANXA4chr2

70047953

+SMU1chr9

33053288

-
intron-3CDSENST00000418066ENST00000536631ANXA4chr2

70047953

+SMU1chr9

33053288

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409920ANXA4chr270047953+ENST00000397149SMU1chr933053288-703710882481507419
ENST00000409920ANXA4chr270047953+ENST00000536631SMU1chr933053288-156710882481507419
ENST00000394295ANXA4chr270047953+ENST00000397149SMU1chr933053288-710311542481573441
ENST00000394295ANXA4chr270047953+ENST00000536631SMU1chr933053288-163311542481573441
ENST00000536030ANXA4chr270047953+ENST00000397149SMU1chr933053288-700810592011478425
ENST00000536030ANXA4chr270047953+ENST00000536631SMU1chr933053288-153810592011478425

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409920ENST00000397149ANXA4chr270047953+SMU1chr933053288-0.0001852050.9998148
ENST00000409920ENST00000536631ANXA4chr270047953+SMU1chr933053288-0.0014387550.9985612
ENST00000394295ENST00000397149ANXA4chr270047953+SMU1chr933053288-0.0002693520.99973065
ENST00000394295ENST00000536631ANXA4chr270047953+SMU1chr933053288-0.0019055360.9980945
ENST00000536030ENST00000397149ANXA4chr270047953+SMU1chr933053288-0.000132320.9998677
ENST00000536030ENST00000536631ANXA4chr270047953+SMU1chr933053288-0.0010130210.998987

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Fusion Genomic Features for ANXA4-SMU1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANXA4-SMU1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:70047953/chr9:33053288)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANXA4chr2:70047953chr9:33053288ENST00000394295+121314_85302322.0RepeatAnnexin 1
HgeneANXA4chr2:70047953chr9:33053288ENST00000394295+1213169_241302322.0RepeatAnnexin 3
HgeneANXA4chr2:70047953chr9:33053288ENST00000394295+121386_157302322.0RepeatAnnexin 2
TgeneSMU1chr2:70047953chr9:33053288ENST00000397149812395_436374514.0RepeatWD 5
TgeneSMU1chr2:70047953chr9:33053288ENST00000397149812440_479374514.0RepeatWD 6
TgeneSMU1chr2:70047953chr9:33053288ENST00000397149812482_513374514.0RepeatWD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANXA4chr2:70047953chr9:33053288ENST00000394295+1213245_316302322.0RepeatAnnexin 4
TgeneSMU1chr2:70047953chr9:33053288ENST0000039714981240_92374514.0DomainCTLH
TgeneSMU1chr2:70047953chr9:33053288ENST000003971498126_38374514.0DomainLisH
TgeneSMU1chr2:70047953chr9:33053288ENST00000397149812212_253374514.0RepeatWD 1
TgeneSMU1chr2:70047953chr9:33053288ENST00000397149812262_303374514.0RepeatWD 2
TgeneSMU1chr2:70047953chr9:33053288ENST00000397149812305_346374514.0RepeatWD 3
TgeneSMU1chr2:70047953chr9:33053288ENST00000397149812347_386374514.0RepeatWD 4


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Fusion Gene Sequence for ANXA4-SMU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5067_5067_1_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000394295_SMU1_chr9_33053288_ENST00000397149_length(transcript)=7103nt_BP=1154nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGACTTGATAG
ACGACCTGAAGTCAGAACTGAGTGGCAACTTCGAGCAGGTGATTGTGGGGATGATGACGCCCACGGTGCTGTATGACGTGCAAGAGCTGC
GAAGGGCCATGAAGGGAGCCGGCACTGATGAGGGCTGCCTAATTGAGATCCTGGCCTCCCGGACCCCTGAGGAGATCCGGCGCATAAGCC
AAACCTACCAGCAGCAATATGGACGGAGCCTTGAAGATGACATTCGCTCTGACACATCGTTCATGTTCCAGCGAGTGCTGGTGTCTCTGT
CAGCTGGTGGGAGGGATGAAGGAAATTATCTGGACGATGCTCTCGTGAGACAGGATGCCCAGGACCTGTATGAGGCTGGAGAGAAGAAAT
GGGGGACAGATGAGGTGAAATTTCTAACTGTTCTCTGTTCCCGGAACCGAAATCACCTGTTGCATGTGTTTGATGAATACAAAAGGATAT
CACAGAAGGATATTGAACAGAGTATTAAATCTGAAACATCTGGTAGCTTTGAAGATGCTCTGCTGGCTATAGTAAAGTGCATGAGGAACA
AATCTGCATATTTTGCTGAAAAGCTCTATAAATCGATGAAGGGCTTGGGCACCGATGATAACACCCTCATCAGAGTGATGGTTTCTCGAG
CAGAAATTGACATGTTGGATATCCGGGCACACTTCAAGAGACTCTATGGAAAGTCTCTGTACTCGTTCATCAAGATCTGGAATATGAAGA
CCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTGATTCTACTTCCTAAAAACC
CTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGATTGTCAGAAGCTTCAGTTCTGGTAAAA
GAGAAGGTGGGGACTTTGTTTGCTGTGCCCTCTCTCCCCGTGGTGAATGGATCTACTGTGTAGGGGAGGACTTTGTGCTCTACTGTTTCA
GTACAGTCACTGGCAAACTGGAGAGAACTTTGACAGTGCACGAGAAGGATGTGATTGGTATTGCACATCACCCTCATCAGAACCTGATTG
CTACCTACAGTGAAGATGGACTCCTAAAGCTCTGGAAACCATAATTCAACTTTTCTTTTTAAATCAGCTCGAAAGCATGTACTTAAATGA
AGCATATTCATGTAATGTGCTTTTTTTTTTTTTTGCCAGCTTTTCTAAGCAAATAGATTGTCTGAATTAGTCACAGAATAATTTTGTGAA
AATTCATGTTTAAGTAGCAACTACCCTTTCTTTTTTTATATATTTTTAAGGTATTAGTTTATCTTCTTCTAACTGGTGCAGTCACTTAAT
GTTTTCATTAATCTTCGACCTGGAGAGTGAAATACTGATATTTCTAGAAAAAAATTCTACTCCTCTGATTATTTGAAATGCTGAGGAAAA
TGTCCCTCCCATAGTAAAACTTGTAAATAAGGAACTATATCATATTCAGTAGCTGTGTTCTGTTCCATCTTTTTTTTTTTTTTTGAGATG
GAGTTTTGCTTGTTGCCCAGGCTGGAGTGCAGCGGCACGATCTTGGTTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCTTGCC
TCAGCCTCCCGAGTAGCTGGGGACTACAGGTGTGCGACACCATGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCAT
GTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAAGGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATCACAGGCGTGAGCCACCAT
GCCCGGCCCATCTTTTTTTTTTTTTTTTTTTTTAAAGATGTTAATAAACTTTATACCTTTCTGGAGACTTTGTTCTAAAATGTACATAAA
TGCTCATCTAGTTAACATATTTACTTAGAATGTGGGAGGAGGAGTCACATTATTATCCCTGAATCTCAAGTACAGCAGAAGTGAATTCCT
GGGATAGTAGGATAGACTAACATGTAAAAAGGCCAGGTGATGCATAGGTTCTCATTTCACTGCCCTCAGCCTTCCTCTCCTTCTGAGCTG
TGCCTTCTCACATGTTCAGTCAACTCCAGGGAATATTGTCTCCATCTTCTGGATAGAACTAGTTGCAGGATCCGTTACAAGAATTCAGAG
TTTTGGCATCTCCCCTTTGTATGTTGTAGGAGAAGGTTTGGCATTGAAAATGTGCTGTTGTTCCAAAGAAAAATTAGCAAAGGACTTGAG
ATTTAGAAAAGTCTCCTTTGTAATGTGCATCATTACCAGTTATCTAAAGAAAAACATGTAAAAGCCAACAAAACCCTTGAAAATATTTTG
CATATGGATGTCTGTTTCACGTTTCAACTGAAGATGTATAGAGCACCTCTGATGATGAGGAAGATACCATGCTAGGCAGTACTTTCAAGA
ACGTGAGTTCTTATTTCTGCAGGCCTTTTGTGCCCCCTTTTAAATGTTAGCATTTATTAGGTACAAACTAGTGGGGAAGGTTTTTTTAAA
AAGTTTTGCAGTCTTGTAATTTACCTTTTTAAAAAATTTATTTTATTTTTCTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCA
GTGGTGCCATCTCAGCTAACTGCAACTTCCACTTCCCAGGTTCAAGCGATTCTCCTGCCTTAGCCTCCCAAGTAGCTGGGACTACAGGCG
CATGCCAGCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGCGGGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAG
GTGATCCGCCTGCCCTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCAGCCTTGTAATTTACCTTTGATGGTGACCT
GAAATGCAGTATGATCCTATATGTGGCACGTAGTAATGTTCAGTGTTTGCTGAATTAATTCTGGGCAGCACTAAGAAATCCCTCTTTCCC
AGTCATATTCTATAACACATTTCCCATTTGCCACAAAACCTGCAGCTTTTTGGTCCAGGTAATGACATTTGCTGCCATTTTGATGATTTA
AAAATGGTCGTGGGAGTTGAACATAGTCATGAATTCAGGATTCCTGAGCATGTAGACAGTCATCCCAGTGGAAAGACACGTTCACTTAAG
AGAAGTTTAAGTTAGAGGAAACAGTTTATGCTAAAAAAATTTTTAGAAAAGTCCTTGAGAATTTTTGATTTAGTCTTGACCTCATGAAGC
TGGTAGTTATGATGTGCATAGTTTGTATCACCGTTTATGAAGATGGAGAATCTAGTCAGCACGTGTTGGTTTATTCTAGGAATTTTTAGG
GAACACTTCTGTTGCTGGCACCAGGTGATGAATATGGTTAAAAAAAGACTCGTTTCTGCCTAAACATAGGGAAGAAGAGCAAATTAAAAG
GAGTAATTAAAACTGATAAAAGCTCAAGTTACCTTTGTGATGATGAGGCGGGCAGTTAACGCGAAAGGGTTGGGAAAGGCTTCCTGGAGG
GACTAGGGGGCGGTCTAAGCACAGGGAACCTAACCGGGGACTCCAGTGTGGCACAGCGGCAAGGTATGTGCTGGGCAAAATGATAGGTGT
CTTGGGAGACCAGGCAAAGAGAGCTGGATTAGGAGCCGTTAAGTATATATTTTTCTTCTTTTTAAATAAAATAATGCACTGGGTGAACAT
GTAAACGCTAAGTTGAAAATCTGCCTTTCCCAGGTAACCCTTGTTAATCTTTCTACAACTTCATTTCGTACAAACCTGAAAAACACACTG
ATTTTGTCTTTAAATGGGCACACGCTGCTTACACTCCTCGGCGCCTAGCCTTTCTGAAGCCCCACGCGGCCGTCCCTCCAGCATTGAAGG
CTGGGGCAGCCCAGCTCCCCTCCAGCGCCCTTACAGCCAGACCGCGGCGGGGTCGGGCCGCGCACGCGCAGGGCGGACGGCCGGATCTGG
GGCGCCGCTGCTCCGGGTGGTCGGAGGTAGGAGTCCCATCTTGGGTCCAGGGCCGGTAGAGCCCCTTACCGGGGGTAGGGAGACTGCGCA
CCCGCTAGAGCCAACTGTCAGGGCCTGCAGACGTCGGGTGACGTCACTGTTACAAAATTGGCGGTCACATCGTCTTAAGGGCCGGTGGCA
GCGGCTGCGCGAACGGGAGTTGGCTGCCGGGAATCAGTGCTCACTTCCTTCTGAATTGGGCGTGTGCAGTCGGTTCCTAGGGAAGTGCTC
TGCTGCAGCCACCAGATTTAACGGATGCTGCTCTCTAGCACTTAACATAGAAGCTAAACTACCTGGCGTTAAAATTAATTCCATGAGCAT
AAGGACATTTGTCCTATCCCCTATTCTGCTGTTGAATTAATGACTGGAAAACATTGCGCGGAGGTATTTGGGAGTAGTATGGCTTTTTTT
TTTTTTTTTTTTTTAACAGCAAATGGTATAAATCTCAGGTACAATTCAGTATCTTCTTCACCAGTTGTTTTTTTTCAGCATGTATTATTA
CTACCACTAACGGCCTCTGTTGAGCCCTTCCTTGCTATGTAAGCAGCCATATTTAATTCTCAGAACAATGTAATGAGGGTGCGCAAATGC
ACATGAAGAAACAGGTTTCCAGACGTGAGGCACCTAACTCAGTCCAACTTGCACGAAGCTCGCATTGAAAACCAGATGTGACTCCGAAGC
TAGGTTTTTTTTCTCTCTTGCCTCACTCTCAATATTGCTGTCAGTTCCTCCTCAATCTTTAGGTTTGGGCAGGGACAAAGAATACATGGA
TTGTTCCTCCACATGCTGCAAACACATTCACCTAAGCAGAGCACAGGTAGTGAGATGAGTAGAGAGAACTGAATTAGAGGATTCTGGATG
TCAGTCTTTGCTGTCACTTCTTTTGGCTTGTGCTAGAACAGTGGTTCTTACAAGTGTCACGTGATAGACACATTCTAAGGTCCTATCCCA
GACCTACAGAATCAGAAATTGGTGGTGGGGCCCAGCAAGCGTGCTCAAATTTGAGAGCAGGTAGACTACAGGGTAGTTTCCGCATATACA
AAAGGTGTTTTAATTCTTGCTGTCAGTCTCAGAAGTTTCATGCTGAGATAACCAAATTTAAATGATAAAGGTGCAAGACTGACTCTTAAA
ATCACATTTTTTCAAATTGCCATAGCTTGCTAGTGTTCTCATTCACTGTGCTTTTACAGCTTCATTTTCCACTATTTTAAGAGAAGAAAT
TGCTATGAAGTGTATGTCCAAGTGAGGAAGTTCCCTGGTCTGAGGTTGTTTAAAACTTACAATAGGCCGGGCACGGTGGCTCAAGCCTGT
AATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGTTCAAGACCACCCTGGCCAACATGGTGACACCCTGTCTCTA
CTAAGGATACAAAATTAGCCGGGCATGGTGGCACACGCCTGTAGTCCCAGCTACCTAGGAGGCTGAGGCAGGAGAATAGCTGGAACCCGG
GAGGCAGAGGTTGCAGTGAGCTGAGACTGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTTGGTCTCAAAAACAAAAAACAAAA
AAACCAAACTTGGAATAGCAAGGGCTGCCCATTATTTAACCTTCCACGGCAATTTTAACAGTGGTATTCTGTTCCAAGTGGTTAATATTA
AATCCATGTGTCAGTGTTGGTGGCTTTCAACCTTGGCTGCGCATAATCATTTTGATGCTTAGGCTACACCCAGCCGAGTTATACAGAATC
CCTGGAGGGTGGGACCTGATGAGTGTTTTAATGTTTCCCGGGTAATTCCAATGGTAGCCAAGGTTAAGAACCAGTACCGTACGTACAAAA
AAGTTGAGAAGCTAATTTCACGTACAGAAAATTTGCCACTGTTCCAAGAGCACTCTCAAGCGACATAATTGGCCTCTACTCCTATTCCCT
ACAAGTATGAATGGGCAGGAGAAGCATCACAGAGAAAGCAGAGTTAGTGCTGGAACTTGTATTTTTGTGGATGATGACCTTGGTTAATGT
TTTTTCATAGGCTCTGTTTCATAGGCTTTGTTTTTTCATAGGCTCTCCCTCATTACATTGTTCTGAGAATTAAATATGGCTGCTTACATA
GTAATGAAGGGTTCAACAGAGGCTGTTAGTGGTAGTAATAATACAAGCTGAAAAACTACACAGACAAACCTATCAGTTTCTGCCTCTTCA
GGATATAACTATTAGGTTAGTGCAAAAGTAATTGCGGTTTTTGCCATTAAAAGTAATGGCACATTACTTTTGCACCAACCGACCTAATAT
GACTTTCTTTTAGTGTTCTTAGGATTTTTAATTGTAAAACATGTAACAAATTTTCCTAAACAATTGTGCAATTCAGTGGCATTATTTACG
ATGTTACGCAACCACTATTGTATTTCCAAAATGTCATCACCCTAAACAGAAGCCCTGTAACATTGTCAATTAACTTCTCCTTCCCTTCCC
CTCAGCCTTTGGTACTGTTTCTGCCTCAATGCATTTGTCTAAGTTTAGTTCATATAAGTGAAATTATACAATACTTGTCCTTTTTTATCT
GGCTTATTTCATTTAGCATGTTTTAAAGGTTCATCCATGTATCAAACAGTAAAGTGCTTCATATTTGGGGGAAGTATAAAAAG

>5067_5067_1_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000394295_SMU1_chr9_33053288_ENST00000397149_length(amino acids)=441AA_BP=302
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVIVGMMTPTV
LYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQDL
YEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAEKLYKSMKGLGTDDNTL
IRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIV
RSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP

--------------------------------------------------------------
>5067_5067_2_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000394295_SMU1_chr9_33053288_ENST00000536631_length(transcript)=1633nt_BP=1154nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGACTTGATAG
ACGACCTGAAGTCAGAACTGAGTGGCAACTTCGAGCAGGTGATTGTGGGGATGATGACGCCCACGGTGCTGTATGACGTGCAAGAGCTGC
GAAGGGCCATGAAGGGAGCCGGCACTGATGAGGGCTGCCTAATTGAGATCCTGGCCTCCCGGACCCCTGAGGAGATCCGGCGCATAAGCC
AAACCTACCAGCAGCAATATGGACGGAGCCTTGAAGATGACATTCGCTCTGACACATCGTTCATGTTCCAGCGAGTGCTGGTGTCTCTGT
CAGCTGGTGGGAGGGATGAAGGAAATTATCTGGACGATGCTCTCGTGAGACAGGATGCCCAGGACCTGTATGAGGCTGGAGAGAAGAAAT
GGGGGACAGATGAGGTGAAATTTCTAACTGTTCTCTGTTCCCGGAACCGAAATCACCTGTTGCATGTGTTTGATGAATACAAAAGGATAT
CACAGAAGGATATTGAACAGAGTATTAAATCTGAAACATCTGGTAGCTTTGAAGATGCTCTGCTGGCTATAGTAAAGTGCATGAGGAACA
AATCTGCATATTTTGCTGAAAAGCTCTATAAATCGATGAAGGGCTTGGGCACCGATGATAACACCCTCATCAGAGTGATGGTTTCTCGAG
CAGAAATTGACATGTTGGATATCCGGGCACACTTCAAGAGACTCTATGGAAAGTCTCTGTACTCGTTCATCAAGATCTGGAATATGAAGA
CCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTGATTCTACTTCCTAAAAACC
CTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGATTGTCAGAAGCTTCAGTTCTGGTAAAA
GAGAAGGTGGGGACTTTGTTTGCTGTGCCCTCTCTCCCCGTGGTGAATGGATCTACTGTGTAGGGGAGGACTTTGTGCTCTACTGTTTCA
GTACAGTCACTGGCAAACTGGAGAGAACTTTGACAGTGCACGAGAAGGATGTGATTGGTATTGCACATCACCCTCATCAGAACCTGATTG
CTACCTACAGTGAAGATGGACTCCTAAAGCTCTGGAAACCATAATTCAACTTTTCTTTTTAAATCAGCTCGAAAGCATGTACTTAAATGA
AGCATATTCATGT

>5067_5067_2_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000394295_SMU1_chr9_33053288_ENST00000536631_length(amino acids)=441AA_BP=302
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVIVGMMTPTV
LYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQDL
YEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAEKLYKSMKGLGTDDNTL
IRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIV
RSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP

--------------------------------------------------------------
>5067_5067_3_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000409920_SMU1_chr9_33053288_ENST00000397149_length(transcript)=7037nt_BP=1088nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGACTTGATAG
ACGACCTGAAGTCAGAACTGAGTGGCAACTTCGAGCAGGGAGCCGGCACTGATGAGGGCTGCCTAATTGAGATCCTGGCCTCCCGGACCC
CTGAGGAGATCCGGCGCATAAGCCAAACCTACCAGCAGCAATATGGACGGAGCCTTGAAGATGACATTCGCTCTGACACATCGTTCATGT
TCCAGCGAGTGCTGGTGTCTCTGTCAGCTGGTGGGAGGGATGAAGGAAATTATCTGGACGATGCTCTCGTGAGACAGGATGCCCAGGACC
TGTATGAGGCTGGAGAGAAGAAATGGGGGACAGATGAGGTGAAATTTCTAACTGTTCTCTGTTCCCGGAACCGAAATCACCTGTTGCATG
TGTTTGATGAATACAAAAGGATATCACAGAAGGATATTGAACAGAGTATTAAATCTGAAACATCTGGTAGCTTTGAAGATGCTCTGCTGG
CTATAGTAAAGTGCATGAGGAACAAATCTGCATATTTTGCTGAAAAGCTCTATAAATCGATGAAGGGCTTGGGCACCGATGATAACACCC
TCATCAGAGTGATGGTTTCTCGAGCAGAAATTGACATGTTGGATATCCGGGCACACTTCAAGAGACTCTATGGAAAGTCTCTGTACTCGT
TCATCAAGATCTGGAATATGAAGACCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACA
GTGTGATTCTACTTCCTAAAAACCCTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGATTG
TCAGAAGCTTCAGTTCTGGTAAAAGAGAAGGTGGGGACTTTGTTTGCTGTGCCCTCTCTCCCCGTGGTGAATGGATCTACTGTGTAGGGG
AGGACTTTGTGCTCTACTGTTTCAGTACAGTCACTGGCAAACTGGAGAGAACTTTGACAGTGCACGAGAAGGATGTGATTGGTATTGCAC
ATCACCCTCATCAGAACCTGATTGCTACCTACAGTGAAGATGGACTCCTAAAGCTCTGGAAACCATAATTCAACTTTTCTTTTTAAATCA
GCTCGAAAGCATGTACTTAAATGAAGCATATTCATGTAATGTGCTTTTTTTTTTTTTTGCCAGCTTTTCTAAGCAAATAGATTGTCTGAA
TTAGTCACAGAATAATTTTGTGAAAATTCATGTTTAAGTAGCAACTACCCTTTCTTTTTTTATATATTTTTAAGGTATTAGTTTATCTTC
TTCTAACTGGTGCAGTCACTTAATGTTTTCATTAATCTTCGACCTGGAGAGTGAAATACTGATATTTCTAGAAAAAAATTCTACTCCTCT
GATTATTTGAAATGCTGAGGAAAATGTCCCTCCCATAGTAAAACTTGTAAATAAGGAACTATATCATATTCAGTAGCTGTGTTCTGTTCC
ATCTTTTTTTTTTTTTTTGAGATGGAGTTTTGCTTGTTGCCCAGGCTGGAGTGCAGCGGCACGATCTTGGTTCACTGCAACCTCCGCCTC
CCAGGTTCAAGCGATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGGACTACAGGTGTGCGACACCATGCCTGGCTAATTTTTTTGTATTT
TTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAAGGATCCACCCGCCTTGGCCTCCCAAAGTGCT
GGGATCACAGGCGTGAGCCACCATGCCCGGCCCATCTTTTTTTTTTTTTTTTTTTTTAAAGATGTTAATAAACTTTATACCTTTCTGGAG
ACTTTGTTCTAAAATGTACATAAATGCTCATCTAGTTAACATATTTACTTAGAATGTGGGAGGAGGAGTCACATTATTATCCCTGAATCT
CAAGTACAGCAGAAGTGAATTCCTGGGATAGTAGGATAGACTAACATGTAAAAAGGCCAGGTGATGCATAGGTTCTCATTTCACTGCCCT
CAGCCTTCCTCTCCTTCTGAGCTGTGCCTTCTCACATGTTCAGTCAACTCCAGGGAATATTGTCTCCATCTTCTGGATAGAACTAGTTGC
AGGATCCGTTACAAGAATTCAGAGTTTTGGCATCTCCCCTTTGTATGTTGTAGGAGAAGGTTTGGCATTGAAAATGTGCTGTTGTTCCAA
AGAAAAATTAGCAAAGGACTTGAGATTTAGAAAAGTCTCCTTTGTAATGTGCATCATTACCAGTTATCTAAAGAAAAACATGTAAAAGCC
AACAAAACCCTTGAAAATATTTTGCATATGGATGTCTGTTTCACGTTTCAACTGAAGATGTATAGAGCACCTCTGATGATGAGGAAGATA
CCATGCTAGGCAGTACTTTCAAGAACGTGAGTTCTTATTTCTGCAGGCCTTTTGTGCCCCCTTTTAAATGTTAGCATTTATTAGGTACAA
ACTAGTGGGGAAGGTTTTTTTAAAAAGTTTTGCAGTCTTGTAATTTACCTTTTTAAAAAATTTATTTTATTTTTCTGAGATGGAGTCTTG
CTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCCATCTCAGCTAACTGCAACTTCCACTTCCCAGGTTCAAGCGATTCTCCTGCCTTAGCCT
CCCAAGTAGCTGGGACTACAGGCGCATGCCAGCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGCGGGGGTTTTGCCATGTTGGCCAGG
CTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCTGCCCTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCAGCCTT
GTAATTTACCTTTGATGGTGACCTGAAATGCAGTATGATCCTATATGTGGCACGTAGTAATGTTCAGTGTTTGCTGAATTAATTCTGGGC
AGCACTAAGAAATCCCTCTTTCCCAGTCATATTCTATAACACATTTCCCATTTGCCACAAAACCTGCAGCTTTTTGGTCCAGGTAATGAC
ATTTGCTGCCATTTTGATGATTTAAAAATGGTCGTGGGAGTTGAACATAGTCATGAATTCAGGATTCCTGAGCATGTAGACAGTCATCCC
AGTGGAAAGACACGTTCACTTAAGAGAAGTTTAAGTTAGAGGAAACAGTTTATGCTAAAAAAATTTTTAGAAAAGTCCTTGAGAATTTTT
GATTTAGTCTTGACCTCATGAAGCTGGTAGTTATGATGTGCATAGTTTGTATCACCGTTTATGAAGATGGAGAATCTAGTCAGCACGTGT
TGGTTTATTCTAGGAATTTTTAGGGAACACTTCTGTTGCTGGCACCAGGTGATGAATATGGTTAAAAAAAGACTCGTTTCTGCCTAAACA
TAGGGAAGAAGAGCAAATTAAAAGGAGTAATTAAAACTGATAAAAGCTCAAGTTACCTTTGTGATGATGAGGCGGGCAGTTAACGCGAAA
GGGTTGGGAAAGGCTTCCTGGAGGGACTAGGGGGCGGTCTAAGCACAGGGAACCTAACCGGGGACTCCAGTGTGGCACAGCGGCAAGGTA
TGTGCTGGGCAAAATGATAGGTGTCTTGGGAGACCAGGCAAAGAGAGCTGGATTAGGAGCCGTTAAGTATATATTTTTCTTCTTTTTAAA
TAAAATAATGCACTGGGTGAACATGTAAACGCTAAGTTGAAAATCTGCCTTTCCCAGGTAACCCTTGTTAATCTTTCTACAACTTCATTT
CGTACAAACCTGAAAAACACACTGATTTTGTCTTTAAATGGGCACACGCTGCTTACACTCCTCGGCGCCTAGCCTTTCTGAAGCCCCACG
CGGCCGTCCCTCCAGCATTGAAGGCTGGGGCAGCCCAGCTCCCCTCCAGCGCCCTTACAGCCAGACCGCGGCGGGGTCGGGCCGCGCACG
CGCAGGGCGGACGGCCGGATCTGGGGCGCCGCTGCTCCGGGTGGTCGGAGGTAGGAGTCCCATCTTGGGTCCAGGGCCGGTAGAGCCCCT
TACCGGGGGTAGGGAGACTGCGCACCCGCTAGAGCCAACTGTCAGGGCCTGCAGACGTCGGGTGACGTCACTGTTACAAAATTGGCGGTC
ACATCGTCTTAAGGGCCGGTGGCAGCGGCTGCGCGAACGGGAGTTGGCTGCCGGGAATCAGTGCTCACTTCCTTCTGAATTGGGCGTGTG
CAGTCGGTTCCTAGGGAAGTGCTCTGCTGCAGCCACCAGATTTAACGGATGCTGCTCTCTAGCACTTAACATAGAAGCTAAACTACCTGG
CGTTAAAATTAATTCCATGAGCATAAGGACATTTGTCCTATCCCCTATTCTGCTGTTGAATTAATGACTGGAAAACATTGCGCGGAGGTA
TTTGGGAGTAGTATGGCTTTTTTTTTTTTTTTTTTTTTAACAGCAAATGGTATAAATCTCAGGTACAATTCAGTATCTTCTTCACCAGTT
GTTTTTTTTCAGCATGTATTATTACTACCACTAACGGCCTCTGTTGAGCCCTTCCTTGCTATGTAAGCAGCCATATTTAATTCTCAGAAC
AATGTAATGAGGGTGCGCAAATGCACATGAAGAAACAGGTTTCCAGACGTGAGGCACCTAACTCAGTCCAACTTGCACGAAGCTCGCATT
GAAAACCAGATGTGACTCCGAAGCTAGGTTTTTTTTCTCTCTTGCCTCACTCTCAATATTGCTGTCAGTTCCTCCTCAATCTTTAGGTTT
GGGCAGGGACAAAGAATACATGGATTGTTCCTCCACATGCTGCAAACACATTCACCTAAGCAGAGCACAGGTAGTGAGATGAGTAGAGAG
AACTGAATTAGAGGATTCTGGATGTCAGTCTTTGCTGTCACTTCTTTTGGCTTGTGCTAGAACAGTGGTTCTTACAAGTGTCACGTGATA
GACACATTCTAAGGTCCTATCCCAGACCTACAGAATCAGAAATTGGTGGTGGGGCCCAGCAAGCGTGCTCAAATTTGAGAGCAGGTAGAC
TACAGGGTAGTTTCCGCATATACAAAAGGTGTTTTAATTCTTGCTGTCAGTCTCAGAAGTTTCATGCTGAGATAACCAAATTTAAATGAT
AAAGGTGCAAGACTGACTCTTAAAATCACATTTTTTCAAATTGCCATAGCTTGCTAGTGTTCTCATTCACTGTGCTTTTACAGCTTCATT
TTCCACTATTTTAAGAGAAGAAATTGCTATGAAGTGTATGTCCAAGTGAGGAAGTTCCCTGGTCTGAGGTTGTTTAAAACTTACAATAGG
CCGGGCACGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGTTCAAGACCACCCTGGC
CAACATGGTGACACCCTGTCTCTACTAAGGATACAAAATTAGCCGGGCATGGTGGCACACGCCTGTAGTCCCAGCTACCTAGGAGGCTGA
GGCAGGAGAATAGCTGGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGACTGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACT
TGGTCTCAAAAACAAAAAACAAAAAAACCAAACTTGGAATAGCAAGGGCTGCCCATTATTTAACCTTCCACGGCAATTTTAACAGTGGTA
TTCTGTTCCAAGTGGTTAATATTAAATCCATGTGTCAGTGTTGGTGGCTTTCAACCTTGGCTGCGCATAATCATTTTGATGCTTAGGCTA
CACCCAGCCGAGTTATACAGAATCCCTGGAGGGTGGGACCTGATGAGTGTTTTAATGTTTCCCGGGTAATTCCAATGGTAGCCAAGGTTA
AGAACCAGTACCGTACGTACAAAAAAGTTGAGAAGCTAATTTCACGTACAGAAAATTTGCCACTGTTCCAAGAGCACTCTCAAGCGACAT
AATTGGCCTCTACTCCTATTCCCTACAAGTATGAATGGGCAGGAGAAGCATCACAGAGAAAGCAGAGTTAGTGCTGGAACTTGTATTTTT
GTGGATGATGACCTTGGTTAATGTTTTTTCATAGGCTCTGTTTCATAGGCTTTGTTTTTTCATAGGCTCTCCCTCATTACATTGTTCTGA
GAATTAAATATGGCTGCTTACATAGTAATGAAGGGTTCAACAGAGGCTGTTAGTGGTAGTAATAATACAAGCTGAAAAACTACACAGACA
AACCTATCAGTTTCTGCCTCTTCAGGATATAACTATTAGGTTAGTGCAAAAGTAATTGCGGTTTTTGCCATTAAAAGTAATGGCACATTA
CTTTTGCACCAACCGACCTAATATGACTTTCTTTTAGTGTTCTTAGGATTTTTAATTGTAAAACATGTAACAAATTTTCCTAAACAATTG
TGCAATTCAGTGGCATTATTTACGATGTTACGCAACCACTATTGTATTTCCAAAATGTCATCACCCTAAACAGAAGCCCTGTAACATTGT
CAATTAACTTCTCCTTCCCTTCCCCTCAGCCTTTGGTACTGTTTCTGCCTCAATGCATTTGTCTAAGTTTAGTTCATATAAGTGAAATTA
TACAATACTTGTCCTTTTTTATCTGGCTTATTTCATTTAGCATGTTTTAAAGGTTCATCCATGTATCAAACAGTAAAGTGCTTCATATTT
GGGGGAAGTATAAAAAG

>5067_5067_3_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000409920_SMU1_chr9_33053288_ENST00000397149_length(amino acids)=419AA_BP=280
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQGAGTDEGCLI
EILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFLTVLCSR
NRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRL
YGKSLYSFIKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRG
EWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP

--------------------------------------------------------------
>5067_5067_4_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000409920_SMU1_chr9_33053288_ENST00000536631_length(transcript)=1567nt_BP=1088nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGGCAACCAAAGGAG
GTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAAGATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACG
CCATTATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGACTTGATAG
ACGACCTGAAGTCAGAACTGAGTGGCAACTTCGAGCAGGGAGCCGGCACTGATGAGGGCTGCCTAATTGAGATCCTGGCCTCCCGGACCC
CTGAGGAGATCCGGCGCATAAGCCAAACCTACCAGCAGCAATATGGACGGAGCCTTGAAGATGACATTCGCTCTGACACATCGTTCATGT
TCCAGCGAGTGCTGGTGTCTCTGTCAGCTGGTGGGAGGGATGAAGGAAATTATCTGGACGATGCTCTCGTGAGACAGGATGCCCAGGACC
TGTATGAGGCTGGAGAGAAGAAATGGGGGACAGATGAGGTGAAATTTCTAACTGTTCTCTGTTCCCGGAACCGAAATCACCTGTTGCATG
TGTTTGATGAATACAAAAGGATATCACAGAAGGATATTGAACAGAGTATTAAATCTGAAACATCTGGTAGCTTTGAAGATGCTCTGCTGG
CTATAGTAAAGTGCATGAGGAACAAATCTGCATATTTTGCTGAAAAGCTCTATAAATCGATGAAGGGCTTGGGCACCGATGATAACACCC
TCATCAGAGTGATGGTTTCTCGAGCAGAAATTGACATGTTGGATATCCGGGCACACTTCAAGAGACTCTATGGAAAGTCTCTGTACTCGT
TCATCAAGATCTGGAATATGAAGACCACAGAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACA
GTGTGATTCTACTTCCTAAAAACCCTGAGCACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGATTG
TCAGAAGCTTCAGTTCTGGTAAAAGAGAAGGTGGGGACTTTGTTTGCTGTGCCCTCTCTCCCCGTGGTGAATGGATCTACTGTGTAGGGG
AGGACTTTGTGCTCTACTGTTTCAGTACAGTCACTGGCAAACTGGAGAGAACTTTGACAGTGCACGAGAAGGATGTGATTGGTATTGCAC
ATCACCCTCATCAGAACCTGATTGCTACCTACAGTGAAGATGGACTCCTAAAGCTCTGGAAACCATAATTCAACTTTTCTTTTTAAATCA
GCTCGAAAGCATGTACTTAAATGAAGCATATTCATGT

>5067_5067_4_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000409920_SMU1_chr9_33053288_ENST00000536631_length(amino acids)=419AA_BP=280
MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQGAGTDEGCLI
EILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFLTVLCSR
NRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRL
YGKSLYSFIKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRG
EWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP

--------------------------------------------------------------
>5067_5067_5_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000536030_SMU1_chr9_33053288_ENST00000397149_length(transcript)=7008nt_BP=1059nt
TAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGAGGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGT
GGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGCACAAACAACGAGGAAACAGAAGATTCACCAAACATTTATGAACAGCCAGCTG
TTATAAAGACAAGGGACCAATCTGAAAAATCAGAATAAAGTCTCCTTGTTAAAGCTGCTGCAAGAAACAGGCACCGATGAAGACGCCATT
ATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGACTTGATAGACGAC
CTGAAGTCAGAACTGAGTGGCAACTTCGAGCAGGTGATTGTGGGGATGATGACGCCCACGGTGCTGTATGACGTGCAAGAGCTGCGAAGG
GCCATGAAGGGAGCCGGCACTGATGAGGGCTGCCTAATTGAGATCCTGGCCTCCCGGACCCCTGAGGAGATCCGGCGCATAAGCCAAACC
TACCAGCAGCAATATGGACGGAGCCTTGAAGATGACATTCGCTCTGACACATCGTTCATGTTCCAGCGAGTGCTGGTGTCTCTGTCAGCT
GGTGGGAGGGATGAAGGAAATTATCTGGACGATGCTCTCGTGAGACAGGATGCCCAGGACCTGTATGAGGCTGGAGAGAAGAAATGGGGG
ACAGATGAGGTGAAATTTCTAACTGTTCTCTGTTCCCGGAACCGAAATCACCTGTTGCATGTGTTTGATGAATACAAAAGGATATCACAG
AAGGATATTGAACAGAGTATTAAATCTGAAACATCTGGTAGCTTTGAAGATGCTCTGCTGGCTATAGTAAAGTGCATGAGGAACAAATCT
GCATATTTTGCTGAAAAGCTCTATAAATCGATGAAGGGCTTGGGCACCGATGATAACACCCTCATCAGAGTGATGGTTTCTCGAGCAGAA
ATTGACATGTTGGATATCCGGGCACACTTCAAGAGACTCTATGGAAAGTCTCTGTACTCGTTCATCAAGATCTGGAATATGAAGACCACA
GAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTGATTCTACTTCCTAAAAACCCTGAG
CACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGATTGTCAGAAGCTTCAGTTCTGGTAAAAGAGAA
GGTGGGGACTTTGTTTGCTGTGCCCTCTCTCCCCGTGGTGAATGGATCTACTGTGTAGGGGAGGACTTTGTGCTCTACTGTTTCAGTACA
GTCACTGGCAAACTGGAGAGAACTTTGACAGTGCACGAGAAGGATGTGATTGGTATTGCACATCACCCTCATCAGAACCTGATTGCTACC
TACAGTGAAGATGGACTCCTAAAGCTCTGGAAACCATAATTCAACTTTTCTTTTTAAATCAGCTCGAAAGCATGTACTTAAATGAAGCAT
ATTCATGTAATGTGCTTTTTTTTTTTTTTGCCAGCTTTTCTAAGCAAATAGATTGTCTGAATTAGTCACAGAATAATTTTGTGAAAATTC
ATGTTTAAGTAGCAACTACCCTTTCTTTTTTTATATATTTTTAAGGTATTAGTTTATCTTCTTCTAACTGGTGCAGTCACTTAATGTTTT
CATTAATCTTCGACCTGGAGAGTGAAATACTGATATTTCTAGAAAAAAATTCTACTCCTCTGATTATTTGAAATGCTGAGGAAAATGTCC
CTCCCATAGTAAAACTTGTAAATAAGGAACTATATCATATTCAGTAGCTGTGTTCTGTTCCATCTTTTTTTTTTTTTTTGAGATGGAGTT
TTGCTTGTTGCCCAGGCTGGAGTGCAGCGGCACGATCTTGGTTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCTTGCCTCAGC
CTCCCGAGTAGCTGGGGACTACAGGTGTGCGACACCATGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGG
CCAGGCTGGTCTCAAACTCCTGACCTCAAAGGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATCACAGGCGTGAGCCACCATGCCCG
GCCCATCTTTTTTTTTTTTTTTTTTTTTAAAGATGTTAATAAACTTTATACCTTTCTGGAGACTTTGTTCTAAAATGTACATAAATGCTC
ATCTAGTTAACATATTTACTTAGAATGTGGGAGGAGGAGTCACATTATTATCCCTGAATCTCAAGTACAGCAGAAGTGAATTCCTGGGAT
AGTAGGATAGACTAACATGTAAAAAGGCCAGGTGATGCATAGGTTCTCATTTCACTGCCCTCAGCCTTCCTCTCCTTCTGAGCTGTGCCT
TCTCACATGTTCAGTCAACTCCAGGGAATATTGTCTCCATCTTCTGGATAGAACTAGTTGCAGGATCCGTTACAAGAATTCAGAGTTTTG
GCATCTCCCCTTTGTATGTTGTAGGAGAAGGTTTGGCATTGAAAATGTGCTGTTGTTCCAAAGAAAAATTAGCAAAGGACTTGAGATTTA
GAAAAGTCTCCTTTGTAATGTGCATCATTACCAGTTATCTAAAGAAAAACATGTAAAAGCCAACAAAACCCTTGAAAATATTTTGCATAT
GGATGTCTGTTTCACGTTTCAACTGAAGATGTATAGAGCACCTCTGATGATGAGGAAGATACCATGCTAGGCAGTACTTTCAAGAACGTG
AGTTCTTATTTCTGCAGGCCTTTTGTGCCCCCTTTTAAATGTTAGCATTTATTAGGTACAAACTAGTGGGGAAGGTTTTTTTAAAAAGTT
TTGCAGTCTTGTAATTTACCTTTTTAAAAAATTTATTTTATTTTTCTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGT
GCCATCTCAGCTAACTGCAACTTCCACTTCCCAGGTTCAAGCGATTCTCCTGCCTTAGCCTCCCAAGTAGCTGGGACTACAGGCGCATGC
CAGCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGCGGGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGAT
CCGCCTGCCCTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCAGCCTTGTAATTTACCTTTGATGGTGACCTGAAAT
GCAGTATGATCCTATATGTGGCACGTAGTAATGTTCAGTGTTTGCTGAATTAATTCTGGGCAGCACTAAGAAATCCCTCTTTCCCAGTCA
TATTCTATAACACATTTCCCATTTGCCACAAAACCTGCAGCTTTTTGGTCCAGGTAATGACATTTGCTGCCATTTTGATGATTTAAAAAT
GGTCGTGGGAGTTGAACATAGTCATGAATTCAGGATTCCTGAGCATGTAGACAGTCATCCCAGTGGAAAGACACGTTCACTTAAGAGAAG
TTTAAGTTAGAGGAAACAGTTTATGCTAAAAAAATTTTTAGAAAAGTCCTTGAGAATTTTTGATTTAGTCTTGACCTCATGAAGCTGGTA
GTTATGATGTGCATAGTTTGTATCACCGTTTATGAAGATGGAGAATCTAGTCAGCACGTGTTGGTTTATTCTAGGAATTTTTAGGGAACA
CTTCTGTTGCTGGCACCAGGTGATGAATATGGTTAAAAAAAGACTCGTTTCTGCCTAAACATAGGGAAGAAGAGCAAATTAAAAGGAGTA
ATTAAAACTGATAAAAGCTCAAGTTACCTTTGTGATGATGAGGCGGGCAGTTAACGCGAAAGGGTTGGGAAAGGCTTCCTGGAGGGACTA
GGGGGCGGTCTAAGCACAGGGAACCTAACCGGGGACTCCAGTGTGGCACAGCGGCAAGGTATGTGCTGGGCAAAATGATAGGTGTCTTGG
GAGACCAGGCAAAGAGAGCTGGATTAGGAGCCGTTAAGTATATATTTTTCTTCTTTTTAAATAAAATAATGCACTGGGTGAACATGTAAA
CGCTAAGTTGAAAATCTGCCTTTCCCAGGTAACCCTTGTTAATCTTTCTACAACTTCATTTCGTACAAACCTGAAAAACACACTGATTTT
GTCTTTAAATGGGCACACGCTGCTTACACTCCTCGGCGCCTAGCCTTTCTGAAGCCCCACGCGGCCGTCCCTCCAGCATTGAAGGCTGGG
GCAGCCCAGCTCCCCTCCAGCGCCCTTACAGCCAGACCGCGGCGGGGTCGGGCCGCGCACGCGCAGGGCGGACGGCCGGATCTGGGGCGC
CGCTGCTCCGGGTGGTCGGAGGTAGGAGTCCCATCTTGGGTCCAGGGCCGGTAGAGCCCCTTACCGGGGGTAGGGAGACTGCGCACCCGC
TAGAGCCAACTGTCAGGGCCTGCAGACGTCGGGTGACGTCACTGTTACAAAATTGGCGGTCACATCGTCTTAAGGGCCGGTGGCAGCGGC
TGCGCGAACGGGAGTTGGCTGCCGGGAATCAGTGCTCACTTCCTTCTGAATTGGGCGTGTGCAGTCGGTTCCTAGGGAAGTGCTCTGCTG
CAGCCACCAGATTTAACGGATGCTGCTCTCTAGCACTTAACATAGAAGCTAAACTACCTGGCGTTAAAATTAATTCCATGAGCATAAGGA
CATTTGTCCTATCCCCTATTCTGCTGTTGAATTAATGACTGGAAAACATTGCGCGGAGGTATTTGGGAGTAGTATGGCTTTTTTTTTTTT
TTTTTTTTTAACAGCAAATGGTATAAATCTCAGGTACAATTCAGTATCTTCTTCACCAGTTGTTTTTTTTCAGCATGTATTATTACTACC
ACTAACGGCCTCTGTTGAGCCCTTCCTTGCTATGTAAGCAGCCATATTTAATTCTCAGAACAATGTAATGAGGGTGCGCAAATGCACATG
AAGAAACAGGTTTCCAGACGTGAGGCACCTAACTCAGTCCAACTTGCACGAAGCTCGCATTGAAAACCAGATGTGACTCCGAAGCTAGGT
TTTTTTTCTCTCTTGCCTCACTCTCAATATTGCTGTCAGTTCCTCCTCAATCTTTAGGTTTGGGCAGGGACAAAGAATACATGGATTGTT
CCTCCACATGCTGCAAACACATTCACCTAAGCAGAGCACAGGTAGTGAGATGAGTAGAGAGAACTGAATTAGAGGATTCTGGATGTCAGT
CTTTGCTGTCACTTCTTTTGGCTTGTGCTAGAACAGTGGTTCTTACAAGTGTCACGTGATAGACACATTCTAAGGTCCTATCCCAGACCT
ACAGAATCAGAAATTGGTGGTGGGGCCCAGCAAGCGTGCTCAAATTTGAGAGCAGGTAGACTACAGGGTAGTTTCCGCATATACAAAAGG
TGTTTTAATTCTTGCTGTCAGTCTCAGAAGTTTCATGCTGAGATAACCAAATTTAAATGATAAAGGTGCAAGACTGACTCTTAAAATCAC
ATTTTTTCAAATTGCCATAGCTTGCTAGTGTTCTCATTCACTGTGCTTTTACAGCTTCATTTTCCACTATTTTAAGAGAAGAAATTGCTA
TGAAGTGTATGTCCAAGTGAGGAAGTTCCCTGGTCTGAGGTTGTTTAAAACTTACAATAGGCCGGGCACGGTGGCTCAAGCCTGTAATCC
CAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGTTCAAGACCACCCTGGCCAACATGGTGACACCCTGTCTCTACTAAG
GATACAAAATTAGCCGGGCATGGTGGCACACGCCTGTAGTCCCAGCTACCTAGGAGGCTGAGGCAGGAGAATAGCTGGAACCCGGGAGGC
AGAGGTTGCAGTGAGCTGAGACTGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTTGGTCTCAAAAACAAAAAACAAAAAAACC
AAACTTGGAATAGCAAGGGCTGCCCATTATTTAACCTTCCACGGCAATTTTAACAGTGGTATTCTGTTCCAAGTGGTTAATATTAAATCC
ATGTGTCAGTGTTGGTGGCTTTCAACCTTGGCTGCGCATAATCATTTTGATGCTTAGGCTACACCCAGCCGAGTTATACAGAATCCCTGG
AGGGTGGGACCTGATGAGTGTTTTAATGTTTCCCGGGTAATTCCAATGGTAGCCAAGGTTAAGAACCAGTACCGTACGTACAAAAAAGTT
GAGAAGCTAATTTCACGTACAGAAAATTTGCCACTGTTCCAAGAGCACTCTCAAGCGACATAATTGGCCTCTACTCCTATTCCCTACAAG
TATGAATGGGCAGGAGAAGCATCACAGAGAAAGCAGAGTTAGTGCTGGAACTTGTATTTTTGTGGATGATGACCTTGGTTAATGTTTTTT
CATAGGCTCTGTTTCATAGGCTTTGTTTTTTCATAGGCTCTCCCTCATTACATTGTTCTGAGAATTAAATATGGCTGCTTACATAGTAAT
GAAGGGTTCAACAGAGGCTGTTAGTGGTAGTAATAATACAAGCTGAAAAACTACACAGACAAACCTATCAGTTTCTGCCTCTTCAGGATA
TAACTATTAGGTTAGTGCAAAAGTAATTGCGGTTTTTGCCATTAAAAGTAATGGCACATTACTTTTGCACCAACCGACCTAATATGACTT
TCTTTTAGTGTTCTTAGGATTTTTAATTGTAAAACATGTAACAAATTTTCCTAAACAATTGTGCAATTCAGTGGCATTATTTACGATGTT
ACGCAACCACTATTGTATTTCCAAAATGTCATCACCCTAAACAGAAGCCCTGTAACATTGTCAATTAACTTCTCCTTCCCTTCCCCTCAG
CCTTTGGTACTGTTTCTGCCTCAATGCATTTGTCTAAGTTTAGTTCATATAAGTGAAATTATACAATACTTGTCCTTTTTTATCTGGCTT
ATTTCATTTAGCATGTTTTAAAGGTTCATCCATGTATCAAACAGTAAAGTGCTTCATATTTGGGGGAAGTATAAAAAG

>5067_5067_5_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000536030_SMU1_chr9_33053288_ENST00000397149_length(amino acids)=425AA_BP=286
MKNQNKVSLLKLLQETGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVIVGMMTPTVLYDVQELRRAMKGAGT
DEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFL
TVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIR
AHFKRLYGKSLYSFIKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCC
ALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP

--------------------------------------------------------------
>5067_5067_6_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000536030_SMU1_chr9_33053288_ENST00000536631_length(transcript)=1538nt_BP=1059nt
TAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGAGGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGT
GGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGCACAAACAACGAGGAAACAGAAGATTCACCAAACATTTATGAACAGCCAGCTG
TTATAAAGACAAGGGACCAATCTGAAAAATCAGAATAAAGTCTCCTTGTTAAAGCTGCTGCAAGAAACAGGCACCGATGAAGACGCCATT
ATTAGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGCACCATCGGCAGGGACTTGATAGACGAC
CTGAAGTCAGAACTGAGTGGCAACTTCGAGCAGGTGATTGTGGGGATGATGACGCCCACGGTGCTGTATGACGTGCAAGAGCTGCGAAGG
GCCATGAAGGGAGCCGGCACTGATGAGGGCTGCCTAATTGAGATCCTGGCCTCCCGGACCCCTGAGGAGATCCGGCGCATAAGCCAAACC
TACCAGCAGCAATATGGACGGAGCCTTGAAGATGACATTCGCTCTGACACATCGTTCATGTTCCAGCGAGTGCTGGTGTCTCTGTCAGCT
GGTGGGAGGGATGAAGGAAATTATCTGGACGATGCTCTCGTGAGACAGGATGCCCAGGACCTGTATGAGGCTGGAGAGAAGAAATGGGGG
ACAGATGAGGTGAAATTTCTAACTGTTCTCTGTTCCCGGAACCGAAATCACCTGTTGCATGTGTTTGATGAATACAAAAGGATATCACAG
AAGGATATTGAACAGAGTATTAAATCTGAAACATCTGGTAGCTTTGAAGATGCTCTGCTGGCTATAGTAAAGTGCATGAGGAACAAATCT
GCATATTTTGCTGAAAAGCTCTATAAATCGATGAAGGGCTTGGGCACCGATGATAACACCCTCATCAGAGTGATGGTTTCTCGAGCAGAA
ATTGACATGTTGGATATCCGGGCACACTTCAAGAGACTCTATGGAAAGTCTCTGTACTCGTTCATCAAGATCTGGAATATGAAGACCACA
GAATGTTCAAATACCTTTAAATCCCTGGGCAGCACCGCAGGGACAGATATTACCGTCAACAGTGTGATTCTACTTCCTAAAAACCCTGAG
CACTTTGTGGTGTGCAACAGATCAAACACGGTGGTCATCATGAACATGCAGGGGCAGATTGTCAGAAGCTTCAGTTCTGGTAAAAGAGAA
GGTGGGGACTTTGTTTGCTGTGCCCTCTCTCCCCGTGGTGAATGGATCTACTGTGTAGGGGAGGACTTTGTGCTCTACTGTTTCAGTACA
GTCACTGGCAAACTGGAGAGAACTTTGACAGTGCACGAGAAGGATGTGATTGGTATTGCACATCACCCTCATCAGAACCTGATTGCTACC
TACAGTGAAGATGGACTCCTAAAGCTCTGGAAACCATAATTCAACTTTTCTTTTTAAATCAGCTCGAAAGCATGTACTTAAATGAAGCAT
ATTCATGT

>5067_5067_6_ANXA4-SMU1_ANXA4_chr2_70047953_ENST00000536030_SMU1_chr9_33053288_ENST00000536631_length(amino acids)=425AA_BP=286
MKNQNKVSLLKLLQETGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVIVGMMTPTVLYDVQELRRAMKGAGT
DEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFL
TVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIR
AHFKRLYGKSLYSFIKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCC
ALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANXA4-SMU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANXA4-SMU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANXA4-SMU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANXA4C0007097Carcinoma1CTD_human
HgeneANXA4C0007134Renal Cell Carcinoma1CTD_human
HgeneANXA4C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneANXA4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneANXA4C0023903Liver neoplasms1CTD_human
HgeneANXA4C0024667Animal Mammary Neoplasms1CTD_human
HgeneANXA4C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneANXA4C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneANXA4C0027627Neoplasm Metastasis1CTD_human
HgeneANXA4C0032927Precancerous Conditions1CTD_human
HgeneANXA4C0033578Prostatic Neoplasms1CTD_human
HgeneANXA4C0205696Anaplastic carcinoma1CTD_human
HgeneANXA4C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneANXA4C0205698Undifferentiated carcinoma1CTD_human
HgeneANXA4C0205699Carcinomatosis1CTD_human
HgeneANXA4C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneANXA4C0282313Condition, Preneoplastic1CTD_human
HgeneANXA4C0345904Malignant neoplasm of liver1CTD_human
HgeneANXA4C0376358Malignant neoplasm of prostate1CTD_human
HgeneANXA4C1257925Mammary Carcinoma, Animal1CTD_human
HgeneANXA4C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneANXA4C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneANXA4C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneANXA4C1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneANXA4C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneANXA4C2239176Liver carcinoma1CTD_human