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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HMGB1-CCNA1 (FusionGDB2 ID:HG3146TG8900)

Fusion Gene Summary for HMGB1-CCNA1

check button Fusion gene summary
Fusion gene informationFusion gene name: HMGB1-CCNA1
Fusion gene ID: hg3146tg8900
HgeneTgene
Gene symbol

HMGB1

CCNA1

Gene ID

3146

8900

Gene namehigh mobility group box 1cyclin A1
SynonymsHMG-1|HMG1|HMG3|SBP-1CT146
Cytomap('HMGB1')('CCNA1')

13q12.3

13q13.3

Type of geneprotein-codingprotein-coding
Descriptionhigh mobility group protein B1AmphoterinSulfoglucuronyl carbohydrate binding proteinhigh-mobility group (nonhistone chromosomal) protein 1cyclin-A1testicular tissue protein Li 34
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000326004, ENST00000339872, 
ENST00000341423, ENST00000399489, 
ENST00000399494, ENST00000405805, 
ENST00000468384, 
Fusion gene scores* DoF score11 X 14 X 4=6163 X 6 X 3=54
# samples 144
** MAII scorelog2(14/616*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/54*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HMGB1 [Title/Abstract] AND CCNA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHMGB1(31036675)-CCNA1(37011766), # samples:1
Anticipated loss of major functional domain due to fusion event.HMGB1-CCNA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HMGB1-CCNA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HMGB1-CCNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HMGB1-CCNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HMGB1-CCNA1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HMGB1-CCNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHMGB1

GO:0002218

activation of innate immune response

24971542

HgeneHMGB1

GO:0002643

regulation of tolerance induction

18631454

HgeneHMGB1

GO:0006357

regulation of transcription by RNA polymerase II

11748232

HgeneHMGB1

GO:0006954

inflammatory response

23146691

HgeneHMGB1

GO:0007204

positive regulation of cytosolic calcium ion concentration

22370717

HgeneHMGB1

GO:0017055

negative regulation of RNA polymerase II transcriptional preinitiation complex assembly

8006019

HgeneHMGB1

GO:0032072

regulation of restriction endodeoxyribonuclease activity

17803946

HgeneHMGB1

GO:0032425

positive regulation of mismatch repair

15014079

HgeneHMGB1

GO:0032689

negative regulation of interferon-gamma production

22473704

HgeneHMGB1

GO:0032733

positive regulation of interleukin-10 production

22473704

HgeneHMGB1

GO:0032755

positive regulation of interleukin-6 production

26961863

HgeneHMGB1

GO:0032757

positive regulation of interleukin-8 production

26961863

HgeneHMGB1

GO:0033151

V(D)J recombination

9166431

HgeneHMGB1

GO:0035711

T-helper 1 cell activation

22473704

HgeneHMGB1

GO:0043065

positive regulation of apoptotic process

19800306

HgeneHMGB1

GO:0043277

apoptotic cell clearance

18768881

HgeneHMGB1

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

19800306

HgeneHMGB1

GO:0043371

negative regulation of CD4-positive, alpha-beta T cell differentiation

22473704

HgeneHMGB1

GO:0043388

positive regulation of DNA binding

11748232|19223331

HgeneHMGB1

GO:0043410

positive regulation of MAPK cascade

12765338

HgeneHMGB1

GO:0043537

negative regulation of blood vessel endothelial cell migration

23148224

HgeneHMGB1

GO:0045944

positive regulation of transcription by RNA polymerase II

19223331

HgeneHMGB1

GO:0046330

positive regulation of JNK cascade

12765338

HgeneHMGB1

GO:0050716

positive regulation of interleukin-1 secretion

12765338

HgeneHMGB1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22370717

HgeneHMGB1

GO:0090026

positive regulation of monocyte chemotaxis

22370717

HgeneHMGB1

GO:0097350

neutrophil clearance

18768881

HgeneHMGB1

GO:1990774

tumor necrosis factor secretion

12765338

HgeneHMGB1

GO:2000343

positive regulation of chemokine (C-X-C motif) ligand 2 production

26961863

HgeneHMGB1

GO:2000426

negative regulation of apoptotic cell clearance

20826760

HgeneHMGB1

GO:2000778

positive regulation of interleukin-6 secretion

12765338


check buttonFusion gene breakpoints across HMGB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CCNA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-KD-A5QS-01AHMGB1chr13

31036675

-CCNA1chr13

37011766

+


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Fusion Gene ORF analysis for HMGB1-CCNA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000326004ENST00000255465HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000326004ENST00000418263HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000326004ENST00000463403HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000339872ENST00000255465HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000339872ENST00000418263HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000339872ENST00000463403HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000341423ENST00000255465HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000341423ENST00000418263HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000341423ENST00000463403HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000399489ENST00000255465HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000399489ENST00000418263HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000399489ENST00000463403HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000399494ENST00000255465HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000399494ENST00000418263HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000399494ENST00000463403HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000405805ENST00000255465HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000405805ENST00000418263HMGB1chr13

31036675

-CCNA1chr13

37011766

+
5CDS-3UTRENST00000405805ENST00000463403HMGB1chr13

31036675

-CCNA1chr13

37011766

+
Frame-shiftENST00000326004ENST00000440264HMGB1chr13

31036675

-CCNA1chr13

37011766

+
Frame-shiftENST00000326004ENST00000449823HMGB1chr13

31036675

-CCNA1chr13

37011766

+
Frame-shiftENST00000339872ENST00000440264HMGB1chr13

31036675

-CCNA1chr13

37011766

+
Frame-shiftENST00000339872ENST00000449823HMGB1chr13

31036675

-CCNA1chr13

37011766

+
Frame-shiftENST00000341423ENST00000440264HMGB1chr13

31036675

-CCNA1chr13

37011766

+
Frame-shiftENST00000341423ENST00000449823HMGB1chr13

31036675

-CCNA1chr13

37011766

+
Frame-shiftENST00000399489ENST00000440264HMGB1chr13

31036675

-CCNA1chr13

37011766

+
Frame-shiftENST00000399489ENST00000449823HMGB1chr13

31036675

-CCNA1chr13

37011766

+
Frame-shiftENST00000399494ENST00000440264HMGB1chr13

31036675

-CCNA1chr13

37011766

+
Frame-shiftENST00000399494ENST00000449823HMGB1chr13

31036675

-CCNA1chr13

37011766

+
In-frameENST00000405805ENST00000440264HMGB1chr13

31036675

-CCNA1chr13

37011766

+
In-frameENST00000405805ENST00000449823HMGB1chr13

31036675

-CCNA1chr13

37011766

+
intron-3CDSENST00000468384ENST00000440264HMGB1chr13

31036675

-CCNA1chr13

37011766

+
intron-3CDSENST00000468384ENST00000449823HMGB1chr13

31036675

-CCNA1chr13

37011766

+
intron-3UTRENST00000468384ENST00000255465HMGB1chr13

31036675

-CCNA1chr13

37011766

+
intron-3UTRENST00000468384ENST00000418263HMGB1chr13

31036675

-CCNA1chr13

37011766

+
intron-3UTRENST00000468384ENST00000463403HMGB1chr13

31036675

-CCNA1chr13

37011766

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405805HMGB1chr1331036675-ENST00000449823CCNA1chr1337011766+273014129412512523
ENST00000405805HMGB1chr1331036675-ENST00000440264CCNA1chr1337011766+273014129412512523

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405805ENST00000449823HMGB1chr1331036675-CCNA1chr1337011766+0.0006991640.99930084
ENST00000405805ENST00000440264HMGB1chr1331036675-CCNA1chr1337011766+0.0006991640.99930084

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Fusion Genomic Features for HMGB1-CCNA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HMGB1chr1331036674-CCNA1chr1337011765+3.50E-050.99996495
HMGB1chr1331036674-CCNA1chr1337011765+3.50E-050.99996495

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HMGB1-CCNA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:31036675/chr13:37011766)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHMGB1chr13:31036675chr13:37011766ENST00000339872-459_79157216.0DNA bindingHMG box 1
HgeneHMGB1chr13:31036675chr13:37011766ENST00000341423-459_79157216.0DNA bindingHMG box 1
HgeneHMGB1chr13:31036675chr13:37011766ENST00000399494-459_79157216.0DNA bindingHMG box 1
HgeneHMGB1chr13:31036675chr13:37011766ENST00000405805-459_79157216.0DNA bindingHMG box 1
HgeneHMGB1chr13:31036675chr13:37011766ENST00000339872-4527_43157216.0MotifNuclear localization signal (NLS) 1
HgeneHMGB1chr13:31036675chr13:37011766ENST00000341423-4527_43157216.0MotifNuclear localization signal (NLS) 1
HgeneHMGB1chr13:31036675chr13:37011766ENST00000399494-4527_43157216.0MotifNuclear localization signal (NLS) 1
HgeneHMGB1chr13:31036675chr13:37011766ENST00000405805-4527_43157216.0MotifNuclear localization signal (NLS) 1
HgeneHMGB1chr13:31036675chr13:37011766ENST00000339872-451_10157216.0RegionHeparin-binding
HgeneHMGB1chr13:31036675chr13:37011766ENST00000339872-453_15157216.0RegionLPS binding (delipidated)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000339872-4580_96157216.0RegionLPS binding (Lipid A)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000339872-4589_108157216.0RegionCytokine-stimulating activity
HgeneHMGB1chr13:31036675chr13:37011766ENST00000341423-451_10157216.0RegionHeparin-binding
HgeneHMGB1chr13:31036675chr13:37011766ENST00000341423-453_15157216.0RegionLPS binding (delipidated)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000341423-4580_96157216.0RegionLPS binding (Lipid A)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000341423-4589_108157216.0RegionCytokine-stimulating activity
HgeneHMGB1chr13:31036675chr13:37011766ENST00000399494-451_10157216.0RegionHeparin-binding
HgeneHMGB1chr13:31036675chr13:37011766ENST00000399494-453_15157216.0RegionLPS binding (delipidated)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000399494-4580_96157216.0RegionLPS binding (Lipid A)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000399494-4589_108157216.0RegionCytokine-stimulating activity
HgeneHMGB1chr13:31036675chr13:37011766ENST00000405805-451_10157216.0RegionHeparin-binding
HgeneHMGB1chr13:31036675chr13:37011766ENST00000405805-453_15157216.0RegionLPS binding (delipidated)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000405805-4580_96157216.0RegionLPS binding (Lipid A)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000405805-4589_108157216.0RegionCytokine-stimulating activity
TgeneCCNA1chr13:31036675chr13:37011766ENST0000025546519388_39199466.0Compositional biasNote=Poly-Ala
TgeneCCNA1chr13:31036675chr13:37011766ENST0000041826319388_39198465.0Compositional biasNote=Poly-Ala
TgeneCCNA1chr13:31036675chr13:37011766ENST0000044026419388_39155422.0Compositional biasNote=Poly-Ala
TgeneCCNA1chr13:31036675chr13:37011766ENST0000044982319388_39155422.0Compositional biasNote=Poly-Ala

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHMGB1chr13:31036675chr13:37011766ENST00000339872-45186_215157216.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000341423-45186_215157216.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000399494-45186_215157216.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000405805-45186_215157216.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneHMGB1chr13:31036675chr13:37011766ENST00000339872-4595_163157216.0DNA bindingHMG box 2
HgeneHMGB1chr13:31036675chr13:37011766ENST00000341423-4595_163157216.0DNA bindingHMG box 2
HgeneHMGB1chr13:31036675chr13:37011766ENST00000399494-4595_163157216.0DNA bindingHMG box 2
HgeneHMGB1chr13:31036675chr13:37011766ENST00000405805-4595_163157216.0DNA bindingHMG box 2
HgeneHMGB1chr13:31036675chr13:37011766ENST00000339872-45178_184157216.0MotifNuclear localization signal (NLS) 2
HgeneHMGB1chr13:31036675chr13:37011766ENST00000341423-45178_184157216.0MotifNuclear localization signal (NLS) 2
HgeneHMGB1chr13:31036675chr13:37011766ENST00000399494-45178_184157216.0MotifNuclear localization signal (NLS) 2
HgeneHMGB1chr13:31036675chr13:37011766ENST00000405805-45178_184157216.0MotifNuclear localization signal (NLS) 2
HgeneHMGB1chr13:31036675chr13:37011766ENST00000339872-45150_183157216.0RegionBinding to AGER/RAGE
HgeneHMGB1chr13:31036675chr13:37011766ENST00000341423-45150_183157216.0RegionBinding to AGER/RAGE
HgeneHMGB1chr13:31036675chr13:37011766ENST00000399494-45150_183157216.0RegionBinding to AGER/RAGE
HgeneHMGB1chr13:31036675chr13:37011766ENST00000405805-45150_183157216.0RegionBinding to AGER/RAGE


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Fusion Gene Sequence for HMGB1-CCNA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36863_36863_1_HMGB1-CCNA1_HMGB1_chr13_31036675_ENST00000405805_CCNA1_chr13_37011766_ENST00000440264_length(transcript)=2730nt_BP=1412nt
TTTCTGCGGAGGGATTACGCTGACGAAAGAGACCTGCTTGCGCGTCGCTGTTCCGTGGTCCGCGCGAGCGTGGTCGGGAGCCGCTGGTTC
CTGGGGTGACCCGCGGAGGTGGGAGAGGGAAGGGCTTCCGAAGCCGGCGGGGGTGCCATGGACCCTCTCCGCCGGCGCGGCCTTCACAGC
TGGGCCGCGCCGGGCATCCGTAGTCCGCTCTCCCAAAGCCTCGGTGGAGCTGAAGCTGCCACAGAGTGCATGTTCACAAAGGGTCATCAC
ACACGGAGCTGCCCCTCCCTGTCTCCCTAGAGCCCATCTTCGAGGCCAGGGGCTTTTCTACCAGGATTCTGGGGTGTTTCTCCTCCTTTC
CTCCCTCCCAGATCTTCTCACGGTAAGGGGAGCAGCGAAAGCGCAGGGACTTTGCATTCCACGACCCGTTCTGACTAGTCAACAGCCGAT
CTGTCCCTGCTGCTCTAATTCCAGCTGCCCTGCCTTGTTTTAACTTCAGAGAAAGGGGGAGTTCTCATTTGATAAGTTTAAGCCTTTGCT
TTCGTAGGAAGGTCATGTGGCTTAAGGGACATCGTGACCGCGTATGCTATTTCTGCCTGTGCATTCTAAATCTTGGGGGCAGCATATTCC
AGAAGTCCTTTTGGTCGATTGGTTCTGTGTCCTAGGATAACAATTTGTAGTTTCTGACCATTTCTTTACAGAAAAACCACAATTGGTATT
TTGGACTGCGGGGTTTTTTAGTGGTCTCAAACTAAATGATTATATTCTGGAATAATGCTGACAATTTGGATAGGGTGGTGTGGAGGAAAC
AAGTCTCGTGTAGAAGAAATTATTTAGTAAAAAGGATTTTAGTTTTTGGTACTTCTGAATGCAAATGGCCAAGGAATCCAGCAGTTTGTT
GGGGTTTCTCCAGACAAAAATAGGCTGAAAAATAACTAAACATGGGCAAAGGAGATCCTAAGAAGCCGAGAGGCAAAATGTCATCATATG
CATTTTTTGTGCAAACTTGTCGGGAGGAGCATAAGAAGAAGCACCCAGATGCTTCAGTCAACTTCTCAGAGTTTTCTAAGAAGTGCTCAG
AGAGGTGGAAGACCATGTCTGCTAAAGAGAAAGGAAAATTTGAAGATATGGCAAAAGCGGACAAGGCCCGTTATGAAAGAGAAATGAAAA
CCTATATCCCTCCCAAAGGGGAGACAAAAAAGAAGTTCAAGGATCCCAATGCACCCAAGAGGCCTCCTTCGGCCTTCTTCCTCTTCTGCT
CTGAGTATCGCCCAAAAATCAAAGGAGAACATCCTGGCCTGTCCATTGGTGATGTTGCGAAGAAACTGGGAGAGATGTGGAATAACACTG
CTGCAGATGACAAGCAGCCTTATGAAAAGAAGGCTGCGAAGCTGAAGGAAAAATATGAAAAGGGGATCACAAGAATCAGGTGTTATTCTG
GATCAGAAAATGCCTTCCCTCCAGCTGGAAAGAAAGCACTCCCTGACTGTGGGGTCCAAGAGCCCCCCAAGCAAGGGTTTGACATCTACA
TGGATGAACTAGAGCAGGGGGACAGAGACAGCTGCTCGGTCAGAGAGGGGATGGCATTTGAGGATGTGTATGAAGTAGACACCGGCACAC
TCAAGTCAGACCTGCACTTCCTGCTGGATTTCAACACAGTTTCCCCTATGCTGGTAGATTCATCTCTCCTCTCCCAGTCTGAAGATATAT
CCAGTCTTGGCACAGATGTGATAAATGTGACTGAATATGCTGAAGAAATTTATCAGTACCTTAGGGAAGCTGAAATAAGGCACAGACCCA
AAGCACACTACATGAAGAAGCAGCCAGACATCACGGAAGGCATGCGCACGATTCTGGTGGACTGGCTGGTGGAGGTTGGGGAAGAATATA
AACTTCGAGCAGAGACCCTGTATCTGGCTGTCAACTTCCTGGACAGGTTCCTTTCATGTATGTCTGTTCTGAGAGGGAAACTGCAGCTCG
TAGGAACAGCAGCTATGCTTTTGGCTTCGAAATATGAAGAGATATATCCTCCTGAAGTAGACGAGTTTGTCTATATCACCGATGATACAT
ACACAAAACGACAACTGTTAAAAATGGAACACTTGCTTCTGAAAGTTCTAGCTTTTGATCTGACAGTACCAACCACCAACCAGTTTCTCC
TTCAGTACTTGAGGCGACAAGGAGTGTGCGTCAGGACTGAGAACCTGGCTAAGTACGTAGCAGAGCTGAGTCTACTTGAAGCAGATCCAT
TCTTGAAATATCTTCCTTCACTGATAGCTGCAGCAGCTTTTTGCCTGGCAAACTATACTGTGAACAAGCACTTTTGGCCAGAAACCCTTG
CTGCATTTACAGGGTATTCATTAAGTGAAATTGTGCCTTGCCTGAGTGAGCTTCATAAAGCGTACCTTGATATACCCCATCGACCTCAGC
AAGCAATTAGGGAGAAGTACAAGGCTTCAAAGTACCTGTGTGTGTCCCTCATGGAGCCACCTGCAGTTCTTCTTCTACAATAAGTTTCTG
AATGGAAGCACTTCCAGAACTTCACCTCCATATCAGAAGTGCCAATAATCGTCATAGGCTTCTGCACGTTGGATCAACTAATGTTGTTTA
CAATATAGATGACATTTTAAAAATGTAAATGAATTTAGTTTCCCTTAGACTTTAGTAGTTTGTAATATAGTCCAACATTTTTTAAACAAT

>36863_36863_1_HMGB1-CCNA1_HMGB1_chr13_31036675_ENST00000405805_CCNA1_chr13_37011766_ENST00000440264_length(amino acids)=523AA_BP=157
MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFK
DPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKGITRIRCYSGSENAFPPAGKKAL
PDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYA
EEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEE
IYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAF

--------------------------------------------------------------
>36863_36863_2_HMGB1-CCNA1_HMGB1_chr13_31036675_ENST00000405805_CCNA1_chr13_37011766_ENST00000449823_length(transcript)=2730nt_BP=1412nt
TTTCTGCGGAGGGATTACGCTGACGAAAGAGACCTGCTTGCGCGTCGCTGTTCCGTGGTCCGCGCGAGCGTGGTCGGGAGCCGCTGGTTC
CTGGGGTGACCCGCGGAGGTGGGAGAGGGAAGGGCTTCCGAAGCCGGCGGGGGTGCCATGGACCCTCTCCGCCGGCGCGGCCTTCACAGC
TGGGCCGCGCCGGGCATCCGTAGTCCGCTCTCCCAAAGCCTCGGTGGAGCTGAAGCTGCCACAGAGTGCATGTTCACAAAGGGTCATCAC
ACACGGAGCTGCCCCTCCCTGTCTCCCTAGAGCCCATCTTCGAGGCCAGGGGCTTTTCTACCAGGATTCTGGGGTGTTTCTCCTCCTTTC
CTCCCTCCCAGATCTTCTCACGGTAAGGGGAGCAGCGAAAGCGCAGGGACTTTGCATTCCACGACCCGTTCTGACTAGTCAACAGCCGAT
CTGTCCCTGCTGCTCTAATTCCAGCTGCCCTGCCTTGTTTTAACTTCAGAGAAAGGGGGAGTTCTCATTTGATAAGTTTAAGCCTTTGCT
TTCGTAGGAAGGTCATGTGGCTTAAGGGACATCGTGACCGCGTATGCTATTTCTGCCTGTGCATTCTAAATCTTGGGGGCAGCATATTCC
AGAAGTCCTTTTGGTCGATTGGTTCTGTGTCCTAGGATAACAATTTGTAGTTTCTGACCATTTCTTTACAGAAAAACCACAATTGGTATT
TTGGACTGCGGGGTTTTTTAGTGGTCTCAAACTAAATGATTATATTCTGGAATAATGCTGACAATTTGGATAGGGTGGTGTGGAGGAAAC
AAGTCTCGTGTAGAAGAAATTATTTAGTAAAAAGGATTTTAGTTTTTGGTACTTCTGAATGCAAATGGCCAAGGAATCCAGCAGTTTGTT
GGGGTTTCTCCAGACAAAAATAGGCTGAAAAATAACTAAACATGGGCAAAGGAGATCCTAAGAAGCCGAGAGGCAAAATGTCATCATATG
CATTTTTTGTGCAAACTTGTCGGGAGGAGCATAAGAAGAAGCACCCAGATGCTTCAGTCAACTTCTCAGAGTTTTCTAAGAAGTGCTCAG
AGAGGTGGAAGACCATGTCTGCTAAAGAGAAAGGAAAATTTGAAGATATGGCAAAAGCGGACAAGGCCCGTTATGAAAGAGAAATGAAAA
CCTATATCCCTCCCAAAGGGGAGACAAAAAAGAAGTTCAAGGATCCCAATGCACCCAAGAGGCCTCCTTCGGCCTTCTTCCTCTTCTGCT
CTGAGTATCGCCCAAAAATCAAAGGAGAACATCCTGGCCTGTCCATTGGTGATGTTGCGAAGAAACTGGGAGAGATGTGGAATAACACTG
CTGCAGATGACAAGCAGCCTTATGAAAAGAAGGCTGCGAAGCTGAAGGAAAAATATGAAAAGGGGATCACAAGAATCAGGTGTTATTCTG
GATCAGAAAATGCCTTCCCTCCAGCTGGAAAGAAAGCACTCCCTGACTGTGGGGTCCAAGAGCCCCCCAAGCAAGGGTTTGACATCTACA
TGGATGAACTAGAGCAGGGGGACAGAGACAGCTGCTCGGTCAGAGAGGGGATGGCATTTGAGGATGTGTATGAAGTAGACACCGGCACAC
TCAAGTCAGACCTGCACTTCCTGCTGGATTTCAACACAGTTTCCCCTATGCTGGTAGATTCATCTCTCCTCTCCCAGTCTGAAGATATAT
CCAGTCTTGGCACAGATGTGATAAATGTGACTGAATATGCTGAAGAAATTTATCAGTACCTTAGGGAAGCTGAAATAAGGCACAGACCCA
AAGCACACTACATGAAGAAGCAGCCAGACATCACGGAAGGCATGCGCACGATTCTGGTGGACTGGCTGGTGGAGGTTGGGGAAGAATATA
AACTTCGAGCAGAGACCCTGTATCTGGCTGTCAACTTCCTGGACAGGTTCCTTTCATGTATGTCTGTTCTGAGAGGGAAACTGCAGCTCG
TAGGAACAGCAGCTATGCTTTTGGCTTCGAAATATGAAGAGATATATCCTCCTGAAGTAGACGAGTTTGTCTATATCACCGATGATACAT
ACACAAAACGACAACTGTTAAAAATGGAACACTTGCTTCTGAAAGTTCTAGCTTTTGATCTGACAGTACCAACCACCAACCAGTTTCTCC
TTCAGTACTTGAGGCGACAAGGAGTGTGCGTCAGGACTGAGAACCTGGCTAAGTACGTAGCAGAGCTGAGTCTACTTGAAGCAGATCCAT
TCTTGAAATATCTTCCTTCACTGATAGCTGCAGCAGCTTTTTGCCTGGCAAACTATACTGTGAACAAGCACTTTTGGCCAGAAACCCTTG
CTGCATTTACAGGGTATTCATTAAGTGAAATTGTGCCTTGCCTGAGTGAGCTTCATAAAGCGTACCTTGATATACCCCATCGACCTCAGC
AAGCAATTAGGGAGAAGTACAAGGCTTCAAAGTACCTGTGTGTGTCCCTCATGGAGCCACCTGCAGTTCTTCTTCTACAATAAGTTTCTG
AATGGAAGCACTTCCAGAACTTCACCTCCATATCAGAAGTGCCAATAATCGTCATAGGCTTCTGCACGTTGGATCAACTAATGTTGTTTA
CAATATAGATGACATTTTAAAAATGTAAATGAATTTAGTTTCCCTTAGACTTTAGTAGTTTGTAATATAGTCCAACATTTTTTAAACAAT

>36863_36863_2_HMGB1-CCNA1_HMGB1_chr13_31036675_ENST00000405805_CCNA1_chr13_37011766_ENST00000449823_length(amino acids)=523AA_BP=157
MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFK
DPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKGITRIRCYSGSENAFPPAGKKAL
PDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYA
EEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEE
IYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HMGB1-CCNA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HMGB1-CCNA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HMGB1-CCNA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHMGB1C0021368Inflammation5CTD_human
HgeneHMGB1C0027540Necrosis2CTD_human
HgeneHMGB1C0034189Pyemia2CTD_human
HgeneHMGB1C0036690Septicemia2CTD_human
HgeneHMGB1C0243026Sepsis2CTD_human
HgeneHMGB1C1719672Severe Sepsis2CTD_human
HgeneHMGB1C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneHMGB1C0005398Cholestasis, Extrahepatic1CTD_human
HgeneHMGB1C0013221Drug toxicity1CTD_human
HgeneHMGB1C0015967Fever1CTD_human
HgeneHMGB1C0019193Hepatitis, Toxic1CTD_human
HgeneHMGB1C0020429Hyperalgesia1CTD_human
HgeneHMGB1C0026766Multiple Organ Failure1CTD_human
HgeneHMGB1C0027051Myocardial Infarction1CTD_human
HgeneHMGB1C0027055Myocardial Reperfusion Injury1CTD_human
HgeneHMGB1C0027796Neuralgia1CTD_human
HgeneHMGB1C0034069Pulmonary Fibrosis1CTD_human
HgeneHMGB1C0038870Neuralgia, Supraorbital1CTD_human
HgeneHMGB1C0041755Adverse reaction to drug1CTD_human
HgeneHMGB1C0042656Neuralgia, Vidian1CTD_human
HgeneHMGB1C0151744Myocardial Ischemia1CTD_human
HgeneHMGB1C0234247Neuralgia, Atypical1CTD_human
HgeneHMGB1C0234249Neuralgia, Stump1CTD_human
HgeneHMGB1C0264939Systemic Vasculitis1CTD_human
HgeneHMGB1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneHMGB1C0282548Leukostasis1CTD_human
HgeneHMGB1C0423711Neuralgia, Perineal1CTD_human
HgeneHMGB1C0423712Neuralgia, Iliohypogastric Nerve1CTD_human
HgeneHMGB1C0458247Allodynia1CTD_human
HgeneHMGB1C0751211Hyperalgesia, Primary1CTD_human
HgeneHMGB1C0751212Hyperalgesia, Secondary1CTD_human
HgeneHMGB1C0751213Tactile Allodynia1CTD_human
HgeneHMGB1C0751214Hyperalgesia, Thermal1CTD_human
HgeneHMGB1C0751371Neuralgia, Ilioinguinal1CTD_human
HgeneHMGB1C0751372Nerve Pain1CTD_human
HgeneHMGB1C0751373Paroxysmal Nerve Pain1CTD_human
HgeneHMGB1C0860207Drug-Induced Liver Disease1CTD_human
HgeneHMGB1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneHMGB1C1850383Neuropathy, Painful1CTD_human
HgeneHMGB1C2936719Mechanical Allodynia1CTD_human
HgeneHMGB1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneHMGB1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneHMGB1C4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneHMGB1C4721507Alveolitis, Fibrosing1CTD_human
TgeneC1168401Squamous cell carcinoma of the head and neck2CTD_human
TgeneC0343641Human papilloma virus infection1CTD_human
TgeneC2239176Liver carcinoma1CTD_human