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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:HMOX1-C6orf62 (FusionGDB2 ID:HG3162TG81688) |
Fusion Gene Summary for HMOX1-C6orf62 |
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Fusion gene information | Fusion gene name: HMOX1-C6orf62 | Fusion gene ID: hg3162tg81688 | Hgene | Tgene | Gene symbol | HMOX1 | C6orf62 | Gene ID | 3162 | 81688 |
Gene name | heme oxygenase 1 | chromosome 6 open reading frame 62 | |
Synonyms | HMOX1D|HO-1|HSP32|bK286B10 | Nbla00237|XTP12|dJ30M3.2 | |
Cytomap | ('HMOX1')('C6orf62') 22q12.3 | 6p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | heme oxygenase 1heat shock protein, 32-kDheme oxygenase (decycling) 1 | uncharacterized protein C6orf62HBV X-transactivated gene 12 proteinHBV X-transactivated protein 12HBV XAg-transactivated protein 12 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000216117, | ||
Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 15 X 11 X 6=990 |
# samples | 3 | 15 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(15/990*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HMOX1 [Title/Abstract] AND C6orf62 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | HMOX1(35778674)-C6orf62(24705089), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HMOX1 | GO:0006788 | heme oxidation | 17915953 |
Hgene | HMOX1 | GO:0035094 | response to nicotine | 18205746 |
Hgene | HMOX1 | GO:0042167 | heme catabolic process | 17915953 |
Hgene | HMOX1 | GO:0045766 | positive regulation of angiogenesis | 21788589 |
Hgene | HMOX1 | GO:0048661 | positive regulation of smooth muscle cell proliferation | 17600318 |
Hgene | HMOX1 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 17600318 |
Hgene | HMOX1 | GO:0055072 | iron ion homeostasis | 17915953 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for HMOX1-C6orf62 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for HMOX1-C6orf62 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for HMOX1-C6orf62 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35778674/:24705089) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for HMOX1-C6orf62 |
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Fusion Gene PPI Analysis for HMOX1-C6orf62 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HMOX1-C6orf62 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for HMOX1-C6orf62 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HMOX1 | C0035126 | Reperfusion Injury | 6 | CTD_human |
Hgene | HMOX1 | C0002152 | Alloxan Diabetes | 4 | CTD_human |
Hgene | HMOX1 | C0011853 | Diabetes Mellitus, Experimental | 4 | CTD_human |
Hgene | HMOX1 | C0021368 | Inflammation | 4 | CTD_human |
Hgene | HMOX1 | C0023893 | Liver Cirrhosis, Experimental | 4 | CTD_human |
Hgene | HMOX1 | C0038433 | Streptozotocin Diabetes | 4 | CTD_human |
Hgene | HMOX1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | CTD_human |
Hgene | HMOX1 | C0020538 | Hypertensive disease | 3 | CTD_human |
Hgene | HMOX1 | C0023895 | Liver diseases | 3 | CTD_human |
Hgene | HMOX1 | C0028754 | Obesity | 3 | CTD_human |
Hgene | HMOX1 | C0086565 | Liver Dysfunction | 3 | CTD_human |
Hgene | HMOX1 | C0270715 | Degenerative Diseases, Central Nervous System | 3 | CTD_human |
Hgene | HMOX1 | C0524851 | Neurodegenerative Disorders | 3 | CTD_human |
Hgene | HMOX1 | C0751733 | Degenerative Diseases, Spinal Cord | 3 | CTD_human |
Hgene | HMOX1 | C0009319 | Colitis | 2 | CTD_human |
Hgene | HMOX1 | C0019193 | Hepatitis, Toxic | 2 | CTD_human |
Hgene | HMOX1 | C0021655 | Insulin Resistance | 2 | CTD_human |
Hgene | HMOX1 | C0022116 | Ischemia | 2 | CTD_human |
Hgene | HMOX1 | C0024121 | Lung Neoplasms | 2 | CTD_human |
Hgene | HMOX1 | C0024623 | Malignant neoplasm of stomach | 2 | CTD_human |
Hgene | HMOX1 | C0038356 | Stomach Neoplasms | 2 | CTD_human |
Hgene | HMOX1 | C0242379 | Malignant neoplasm of lung | 2 | CTD_human |
Hgene | HMOX1 | C0860207 | Drug-Induced Liver Disease | 2 | CTD_human |
Hgene | HMOX1 | C0920563 | Insulin Sensitivity | 2 | CTD_human |
Hgene | HMOX1 | C1262760 | Hepatitis, Drug-Induced | 2 | CTD_human |
Hgene | HMOX1 | C1708349 | Hereditary Diffuse Gastric Cancer | 2 | CTD_human |
Hgene | HMOX1 | C3658290 | Drug-Induced Acute Liver Injury | 2 | CTD_human |
Hgene | HMOX1 | C4277682 | Chemical and Drug Induced Liver Injury | 2 | CTD_human |
Hgene | HMOX1 | C4279912 | Chemically-Induced Liver Toxicity | 2 | CTD_human |
Hgene | HMOX1 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
Hgene | HMOX1 | C0002726 | Amyloidosis | 1 | GENOMICS_ENGLAND |
Hgene | HMOX1 | C0002878 | Anemia, Hemolytic | 1 | CTD_human |
Hgene | HMOX1 | C0002879 | Anemia, Hemolytic, Acquired | 1 | CTD_human |
Hgene | HMOX1 | C0002889 | Anemia, Microangiopathic | 1 | CTD_human |
Hgene | HMOX1 | C0004096 | Asthma | 1 | CTD_human |
Hgene | HMOX1 | C0005779 | Blood Coagulation Disorders | 1 | CTD_human |
Hgene | HMOX1 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
Hgene | HMOX1 | C0007273 | Carotid Artery Diseases | 1 | CTD_human |
Hgene | HMOX1 | C0010054 | Coronary Arteriosclerosis | 1 | CTD_human |
Hgene | HMOX1 | C0011265 | Presenile dementia | 1 | CTD_human |
Hgene | HMOX1 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Hgene | HMOX1 | C0011875 | Diabetic Angiopathies | 1 | CTD_human |
Hgene | HMOX1 | C0012715 | Iron Metabolism Disorders | 1 | CTD_human |
Hgene | HMOX1 | C0013221 | Drug toxicity | 1 | CTD_human |
Hgene | HMOX1 | C0016059 | Fibrosis | 1 | CTD_human |
Hgene | HMOX1 | C0018273 | Growth Disorders | 1 | CTD_human |
Hgene | HMOX1 | C0018800 | Cardiomegaly | 1 | CTD_human |
Hgene | HMOX1 | C0018801 | Heart failure | 1 | CTD_human |
Hgene | HMOX1 | C0018802 | Congestive heart failure | 1 | CTD_human |
Hgene | HMOX1 | C0019054 | Hemolysis (disorder) | 1 | CTD_human |
Hgene | HMOX1 | C0019158 | Hepatitis | 1 | CTD_human |
Hgene | HMOX1 | C0019212 | Hepatorenal Syndrome | 1 | CTD_human |
Hgene | HMOX1 | C0020459 | Hyperinsulinism | 1 | CTD_human |
Hgene | HMOX1 | C0020507 | Hyperplasia | 1 | CTD_human |
Hgene | HMOX1 | C0022660 | Kidney Failure, Acute | 1 | CTD_human |
Hgene | HMOX1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Hgene | HMOX1 | C0023186 | Learning Disorders | 1 | CTD_human |
Hgene | HMOX1 | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
Hgene | HMOX1 | C0023290 | Leishmaniasis, Visceral | 1 | CTD_human |
Hgene | HMOX1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | HMOX1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | HMOX1 | C0025945 | Microangiopathy, Diabetic | 1 | CTD_human |
Hgene | HMOX1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | HMOX1 | C0030286 | Pancreatic Diseases | 1 | CTD_human |
Hgene | HMOX1 | C0030567 | Parkinson Disease | 1 | CTD_human |
Hgene | HMOX1 | C0032285 | Pneumonia | 1 | CTD_human |
Hgene | HMOX1 | C0032300 | Lobar Pneumonia | 1 | CTD_human |
Hgene | HMOX1 | C0032914 | Pre-Eclampsia | 1 | CTD_human |
Hgene | HMOX1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | HMOX1 | C0034067 | Pulmonary Emphysema | 1 | CTD_human |
Hgene | HMOX1 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Hgene | HMOX1 | C0035309 | Retinal Diseases | 1 | CTD_human |
Hgene | HMOX1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | HMOX1 | C0038220 | Status Epilepticus | 1 | CTD_human |
Hgene | HMOX1 | C0040053 | Thrombosis | 1 | CTD_human |
Hgene | HMOX1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | HMOX1 | C0087086 | Thrombus | 1 | CTD_human |
Hgene | HMOX1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | HMOX1 | C0152020 | Gastroparesis | 1 | CTD_human |
Hgene | HMOX1 | C0162309 | Adrenoleukodystrophy | 1 | CTD_human |
Hgene | HMOX1 | C0162351 | Contact hypersensitivity | 1 | CTD_human |
Hgene | HMOX1 | C0221013 | Mastocytosis, Systemic | 1 | CTD_human |
Hgene | HMOX1 | C0221021 | Microangiopathic hemolytic anemia | 1 | CTD_human |
Hgene | HMOX1 | C0221227 | Centriacinar Emphysema | 1 | CTD_human |
Hgene | HMOX1 | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
Hgene | HMOX1 | C0235574 | Intravascular hemolysis | 1 | CTD_human |
Hgene | HMOX1 | C0264393 | Panacinar Emphysema | 1 | CTD_human |
Hgene | HMOX1 | C0270823 | Petit mal status | 1 | CTD_human |
Hgene | HMOX1 | C0272203 | Indolent Systemic Mastocytosis | 1 | CTD_human |
Hgene | HMOX1 | C0273115 | Lung Injury | 1 | CTD_human |
Hgene | HMOX1 | C0276496 | Familial Alzheimer Disease (FAD) | 1 | CTD_human |
Hgene | HMOX1 | C0311335 | Grand Mal Status Epilepticus | 1 | CTD_human |
Hgene | HMOX1 | C0312854 | Extravascular Hemolysis | 1 | CTD_human |
Hgene | HMOX1 | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |
Hgene | HMOX1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | HMOX1 | C0393734 | Complex Partial Status Epilepticus | 1 | CTD_human |
Hgene | HMOX1 | C0494463 | Alzheimer Disease, Late Onset | 1 | CTD_human |
Hgene | HMOX1 | C0546126 | Acute Confusional Senile Dementia | 1 | CTD_human |
Hgene | HMOX1 | C0577631 | Carotid Atherosclerosis | 1 | CTD_human |
Hgene | HMOX1 | C0600178 | External Carotid Artery Diseases | 1 | CTD_human |
Hgene | HMOX1 | C0678222 | Breast Carcinoma | 1 | CTD_human |
Hgene | HMOX1 | C0750900 | Alzheimer's Disease, Focal Onset | 1 | CTD_human |
Hgene | HMOX1 | C0750901 | Alzheimer Disease, Early Onset | 1 | CTD_human |
Hgene | HMOX1 | C0750986 | Internal Carotid Artery Diseases | 1 | CTD_human |
Hgene | HMOX1 | C0750987 | Arterial Diseases, Common Carotid | 1 | CTD_human |
Hgene | HMOX1 | C0751262 | Adult Learning Disorders | 1 | CTD_human |
Hgene | HMOX1 | C0751263 | Learning Disturbance | 1 | CTD_human |
Hgene | HMOX1 | C0751265 | Learning Disabilities | 1 | CTD_human |
Hgene | HMOX1 | C0751522 | Status Epilepticus, Subclinical | 1 | CTD_human |
Hgene | HMOX1 | C0751523 | Non-Convulsive Status Epilepticus | 1 | CTD_human |
Hgene | HMOX1 | C0751524 | Simple Partial Status Epilepticus | 1 | CTD_human |
Hgene | HMOX1 | C0887898 | Experimental Lung Inflammation | 1 | CTD_human |
Hgene | HMOX1 | C1112486 | Aggressive Systemic Mastocytosis | 1 | CTD_human |
Hgene | HMOX1 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
Hgene | HMOX1 | C1257963 | Endogenous Hyperinsulinism | 1 | CTD_human |
Hgene | HMOX1 | C1257964 | Exogenous Hyperinsulinism | 1 | CTD_human |
Hgene | HMOX1 | C1257965 | Compensatory Hyperinsulinemia | 1 | CTD_human |
Hgene | HMOX1 | C1330966 | Developmental Academic Disorder | 1 | CTD_human |
Hgene | HMOX1 | C1383860 | Cardiac Hypertrophy | 1 | CTD_human |
Hgene | HMOX1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | HMOX1 | C1527231 | Adrenomyeloneuropathy | 1 | CTD_human |
Hgene | HMOX1 | C1565662 | Acute Kidney Insufficiency | 1 | CTD_human |
Hgene | HMOX1 | C1623038 | Cirrhosis | 1 | CTD_human |
Hgene | HMOX1 | C1846707 | SPINOCEREBELLAR ATAXIA 17 | 1 | CTD_human |
Hgene | HMOX1 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
Hgene | HMOX1 | C1959583 | Myocardial Failure | 1 | CTD_human |
Hgene | HMOX1 | C1961112 | Heart Decompensation | 1 | CTD_human |
Hgene | HMOX1 | C2350344 | Chronic Lung Injury | 1 | CTD_human |
Hgene | HMOX1 | C2350878 | Focal Emphysema | 1 | CTD_human |
Hgene | HMOX1 | C2609414 | Acute kidney injury | 1 | CTD_human |
Hgene | HMOX1 | C2937358 | Cerebral Hemorrhage | 1 | CTD_human |
Hgene | HMOX1 | C3714636 | Pneumonitis | 1 | CTD_human |
Hgene | HMOX1 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
Hgene | HMOX1 | C4721507 | Alveolitis, Fibrosing | 1 | CTD_human |