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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HMOX1-C6orf62 (FusionGDB2 ID:HG3162TG81688)

Fusion Gene Summary for HMOX1-C6orf62

check button Fusion gene summary
Fusion gene informationFusion gene name: HMOX1-C6orf62
Fusion gene ID: hg3162tg81688
HgeneTgene
Gene symbol

HMOX1

C6orf62

Gene ID

3162

81688

Gene nameheme oxygenase 1chromosome 6 open reading frame 62
SynonymsHMOX1D|HO-1|HSP32|bK286B10Nbla00237|XTP12|dJ30M3.2
Cytomap('HMOX1')('C6orf62')

22q12.3

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionheme oxygenase 1heat shock protein, 32-kDheme oxygenase (decycling) 1uncharacterized protein C6orf62HBV X-transactivated gene 12 proteinHBV X-transactivated protein 12HBV XAg-transactivated protein 12
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000216117, 
Fusion gene scores* DoF score3 X 2 X 2=1215 X 11 X 6=990
# samples 315
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/990*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HMOX1 [Title/Abstract] AND C6orf62 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHMOX1(35778674)-C6orf62(24705089), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHMOX1

GO:0006788

heme oxidation

17915953

HgeneHMOX1

GO:0035094

response to nicotine

18205746

HgeneHMOX1

GO:0042167

heme catabolic process

17915953

HgeneHMOX1

GO:0045766

positive regulation of angiogenesis

21788589

HgeneHMOX1

GO:0048661

positive regulation of smooth muscle cell proliferation

17600318

HgeneHMOX1

GO:0048662

negative regulation of smooth muscle cell proliferation

17600318

HgeneHMOX1

GO:0055072

iron ion homeostasis

17915953



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for HMOX1-C6orf62

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HMOX1-C6orf62


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for HMOX1-C6orf62


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35778674/:24705089)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HMOX1-C6orf62


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HMOX1-C6orf62


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HMOX1-C6orf62


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HMOX1-C6orf62


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHMOX1C0035126Reperfusion Injury6CTD_human
HgeneHMOX1C0002152Alloxan Diabetes4CTD_human
HgeneHMOX1C0011853Diabetes Mellitus, Experimental4CTD_human
HgeneHMOX1C0021368Inflammation4CTD_human
HgeneHMOX1C0023893Liver Cirrhosis, Experimental4CTD_human
HgeneHMOX1C0038433Streptozotocin Diabetes4CTD_human
HgeneHMOX1C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
HgeneHMOX1C0020538Hypertensive disease3CTD_human
HgeneHMOX1C0023895Liver diseases3CTD_human
HgeneHMOX1C0028754Obesity3CTD_human
HgeneHMOX1C0086565Liver Dysfunction3CTD_human
HgeneHMOX1C0270715Degenerative Diseases, Central Nervous System3CTD_human
HgeneHMOX1C0524851Neurodegenerative Disorders3CTD_human
HgeneHMOX1C0751733Degenerative Diseases, Spinal Cord3CTD_human
HgeneHMOX1C0009319Colitis2CTD_human
HgeneHMOX1C0019193Hepatitis, Toxic2CTD_human
HgeneHMOX1C0021655Insulin Resistance2CTD_human
HgeneHMOX1C0022116Ischemia2CTD_human
HgeneHMOX1C0024121Lung Neoplasms2CTD_human
HgeneHMOX1C0024623Malignant neoplasm of stomach2CTD_human
HgeneHMOX1C0038356Stomach Neoplasms2CTD_human
HgeneHMOX1C0242379Malignant neoplasm of lung2CTD_human
HgeneHMOX1C0860207Drug-Induced Liver Disease2CTD_human
HgeneHMOX1C0920563Insulin Sensitivity2CTD_human
HgeneHMOX1C1262760Hepatitis, Drug-Induced2CTD_human
HgeneHMOX1C1708349Hereditary Diffuse Gastric Cancer2CTD_human
HgeneHMOX1C3658290Drug-Induced Acute Liver Injury2CTD_human
HgeneHMOX1C4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneHMOX1C4279912Chemically-Induced Liver Toxicity2CTD_human
HgeneHMOX1C0002395Alzheimer's Disease1CTD_human
HgeneHMOX1C0002726Amyloidosis1GENOMICS_ENGLAND
HgeneHMOX1C0002878Anemia, Hemolytic1CTD_human
HgeneHMOX1C0002879Anemia, Hemolytic, Acquired1CTD_human
HgeneHMOX1C0002889Anemia, Microangiopathic1CTD_human
HgeneHMOX1C0004096Asthma1CTD_human
HgeneHMOX1C0005779Blood Coagulation Disorders1CTD_human
HgeneHMOX1C0006142Malignant neoplasm of breast1CTD_human
HgeneHMOX1C0007273Carotid Artery Diseases1CTD_human
HgeneHMOX1C0010054Coronary Arteriosclerosis1CTD_human
HgeneHMOX1C0011265Presenile dementia1CTD_human
HgeneHMOX1C0011616Contact Dermatitis1CTD_human
HgeneHMOX1C0011875Diabetic Angiopathies1CTD_human
HgeneHMOX1C0012715Iron Metabolism Disorders1CTD_human
HgeneHMOX1C0013221Drug toxicity1CTD_human
HgeneHMOX1C0016059Fibrosis1CTD_human
HgeneHMOX1C0018273Growth Disorders1CTD_human
HgeneHMOX1C0018800Cardiomegaly1CTD_human
HgeneHMOX1C0018801Heart failure1CTD_human
HgeneHMOX1C0018802Congestive heart failure1CTD_human
HgeneHMOX1C0019054Hemolysis (disorder)1CTD_human
HgeneHMOX1C0019158Hepatitis1CTD_human
HgeneHMOX1C0019212Hepatorenal Syndrome1CTD_human
HgeneHMOX1C0020459Hyperinsulinism1CTD_human
HgeneHMOX1C0020507Hyperplasia1CTD_human
HgeneHMOX1C0022660Kidney Failure, Acute1CTD_human
HgeneHMOX1C0022661Kidney Failure, Chronic1CTD_human
HgeneHMOX1C0023186Learning Disorders1CTD_human
HgeneHMOX1C0023212Left-Sided Heart Failure1CTD_human
HgeneHMOX1C0023290Leishmaniasis, Visceral1CTD_human
HgeneHMOX1C0023903Liver neoplasms1CTD_human
HgeneHMOX1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneHMOX1C0025945Microangiopathy, Diabetic1CTD_human
HgeneHMOX1C0027626Neoplasm Invasiveness1CTD_human
HgeneHMOX1C0030286Pancreatic Diseases1CTD_human
HgeneHMOX1C0030567Parkinson Disease1CTD_human
HgeneHMOX1C0032285Pneumonia1CTD_human
HgeneHMOX1C0032300Lobar Pneumonia1CTD_human
HgeneHMOX1C0032914Pre-Eclampsia1CTD_human
HgeneHMOX1C0033578Prostatic Neoplasms1CTD_human
HgeneHMOX1C0034067Pulmonary Emphysema1CTD_human
HgeneHMOX1C0034069Pulmonary Fibrosis1CTD_human
HgeneHMOX1C0035309Retinal Diseases1CTD_human
HgeneHMOX1C0036341Schizophrenia1PSYGENET
HgeneHMOX1C0038220Status Epilepticus1CTD_human
HgeneHMOX1C0040053Thrombosis1CTD_human
HgeneHMOX1C0041755Adverse reaction to drug1CTD_human
HgeneHMOX1C0087086Thrombus1CTD_human
HgeneHMOX1C0151744Myocardial Ischemia1CTD_human
HgeneHMOX1C0152020Gastroparesis1CTD_human
HgeneHMOX1C0162309Adrenoleukodystrophy1CTD_human
HgeneHMOX1C0162351Contact hypersensitivity1CTD_human
HgeneHMOX1C0221013Mastocytosis, Systemic1CTD_human
HgeneHMOX1C0221021Microangiopathic hemolytic anemia1CTD_human
HgeneHMOX1C0221227Centriacinar Emphysema1CTD_human
HgeneHMOX1C0235527Heart Failure, Right-Sided1CTD_human
HgeneHMOX1C0235574Intravascular hemolysis1CTD_human
HgeneHMOX1C0264393Panacinar Emphysema1CTD_human
HgeneHMOX1C0270823Petit mal status1CTD_human
HgeneHMOX1C0272203Indolent Systemic Mastocytosis1CTD_human
HgeneHMOX1C0273115Lung Injury1CTD_human
HgeneHMOX1C0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneHMOX1C0311335Grand Mal Status Epilepticus1CTD_human
HgeneHMOX1C0312854Extravascular Hemolysis1CTD_human
HgeneHMOX1C0345904Malignant neoplasm of liver1CTD_human
HgeneHMOX1C0376358Malignant neoplasm of prostate1CTD_human
HgeneHMOX1C0393734Complex Partial Status Epilepticus1CTD_human
HgeneHMOX1C0494463Alzheimer Disease, Late Onset1CTD_human
HgeneHMOX1C0546126Acute Confusional Senile Dementia1CTD_human
HgeneHMOX1C0577631Carotid Atherosclerosis1CTD_human
HgeneHMOX1C0600178External Carotid Artery Diseases1CTD_human
HgeneHMOX1C0678222Breast Carcinoma1CTD_human
HgeneHMOX1C0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneHMOX1C0750901Alzheimer Disease, Early Onset1CTD_human
HgeneHMOX1C0750986Internal Carotid Artery Diseases1CTD_human
HgeneHMOX1C0750987Arterial Diseases, Common Carotid1CTD_human
HgeneHMOX1C0751262Adult Learning Disorders1CTD_human
HgeneHMOX1C0751263Learning Disturbance1CTD_human
HgeneHMOX1C0751265Learning Disabilities1CTD_human
HgeneHMOX1C0751522Status Epilepticus, Subclinical1CTD_human
HgeneHMOX1C0751523Non-Convulsive Status Epilepticus1CTD_human
HgeneHMOX1C0751524Simple Partial Status Epilepticus1CTD_human
HgeneHMOX1C0887898Experimental Lung Inflammation1CTD_human
HgeneHMOX1C1112486Aggressive Systemic Mastocytosis1CTD_human
HgeneHMOX1C1257931Mammary Neoplasms, Human1CTD_human
HgeneHMOX1C1257963Endogenous Hyperinsulinism1CTD_human
HgeneHMOX1C1257964Exogenous Hyperinsulinism1CTD_human
HgeneHMOX1C1257965Compensatory Hyperinsulinemia1CTD_human
HgeneHMOX1C1330966Developmental Academic Disorder1CTD_human
HgeneHMOX1C1383860Cardiac Hypertrophy1CTD_human
HgeneHMOX1C1458155Mammary Neoplasms1CTD_human
HgeneHMOX1C1527231Adrenomyeloneuropathy1CTD_human
HgeneHMOX1C1565662Acute Kidney Insufficiency1CTD_human
HgeneHMOX1C1623038Cirrhosis1CTD_human
HgeneHMOX1C1846707SPINOCEREBELLAR ATAXIA 171CTD_human
HgeneHMOX1C1956346Coronary Artery Disease1CTD_human
HgeneHMOX1C1959583Myocardial Failure1CTD_human
HgeneHMOX1C1961112Heart Decompensation1CTD_human
HgeneHMOX1C2350344Chronic Lung Injury1CTD_human
HgeneHMOX1C2350878Focal Emphysema1CTD_human
HgeneHMOX1C2609414Acute kidney injury1CTD_human
HgeneHMOX1C2937358Cerebral Hemorrhage1CTD_human
HgeneHMOX1C3714636Pneumonitis1CTD_human
HgeneHMOX1C4704874Mammary Carcinoma, Human1CTD_human
HgeneHMOX1C4721507Alveolitis, Fibrosing1CTD_human