![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACACA-ANXA1 (FusionGDB2 ID:HG31TG301) |
Fusion Gene Summary for ACACA-ANXA1 |
![]() |
Fusion gene information | Fusion gene name: ACACA-ANXA1 | Fusion gene ID: hg31tg301 | Hgene | Tgene | Gene symbol | ACACA | ANXA1 | Gene ID | 31 | 301 |
Gene name | acetyl-CoA carboxylase alpha | annexin A1 | |
Synonyms | ACAC|ACACAD|ACC|ACC1|ACCA | ANX1|LPC1 | |
Cytomap | ('ACACA')('ANXA1') 17q12 | 9q21.13 | |
Type of gene | protein-coding | protein-coding | |
Description | acetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha | annexin A1annexin I (lipocortin I)annexin-1calpactin IIcalpactin-2chromobindin-9epididymis secretory sperm binding proteinphospholipase A2 inhibitory protein | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000335166, ENST00000353139, ENST00000360679, ENST00000361253, ENST00000394406, ENST00000416895, ENST00000588142, ENST00000589665, | ||
Fusion gene scores | * DoF score | 44 X 35 X 17=26180 | 24 X 6 X 7=1008 |
# samples | 51 | 23 | |
** MAII score | log2(51/26180*10)=-5.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/1008*10)=-2.13178987255554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACACA [Title/Abstract] AND ANXA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACACA(35569883)-ANXA1(75785309), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ANXA1 | GO:0002548 | monocyte chemotaxis | 15187149 |
Tgene | ANXA1 | GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 25664854 |
Tgene | ANXA1 | GO:0008360 | regulation of cell shape | 15187149 |
Tgene | ANXA1 | GO:0018149 | peptide cross-linking | 10908733 |
Tgene | ANXA1 | GO:0030216 | keratinocyte differentiation | 10908733 |
Tgene | ANXA1 | GO:0031340 | positive regulation of vesicle fusion | 2138016 |
Tgene | ANXA1 | GO:0031532 | actin cytoskeleton reorganization | 15187149 |
Tgene | ANXA1 | GO:0032743 | positive regulation of interleukin-2 production | 17008549 |
Tgene | ANXA1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 22773844 |
Tgene | ANXA1 | GO:0042102 | positive regulation of T cell proliferation | 17008549 |
Tgene | ANXA1 | GO:0045627 | positive regulation of T-helper 1 cell differentiation | 17008549 |
Tgene | ANXA1 | GO:0045629 | negative regulation of T-helper 2 cell differentiation | 17008549 |
Tgene | ANXA1 | GO:0071385 | cellular response to glucocorticoid stimulus | 2936963 |
Tgene | ANXA1 | GO:0071621 | granulocyte chemotaxis | 15187149 |
Tgene | ANXA1 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | 22773844 |
Tgene | ANXA1 | GO:0090303 | positive regulation of wound healing | 25664854 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Top |
Fusion Gene ORF analysis for ACACA-ANXA1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for ACACA-ANXA1 |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Top |
Fusion Protein Features for ACACA-ANXA1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35569883/:75785309) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for ACACA-ANXA1 |
![]() |
Top |
Fusion Gene PPI Analysis for ACACA-ANXA1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ACACA-ANXA1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for ACACA-ANXA1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACACA | C0018801 | Heart failure | 1 | CTD_human |
Hgene | ACACA | C0018802 | Congestive heart failure | 1 | CTD_human |
Hgene | ACACA | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
Hgene | ACACA | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
Hgene | ACACA | C1959583 | Myocardial Failure | 1 | CTD_human |
Hgene | ACACA | C1961112 | Heart Decompensation | 1 | CTD_human |
Hgene | ACACA | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | C0024667 | Animal Mammary Neoplasms | 3 | CTD_human | |
Tgene | C1257925 | Mammary Carcinoma, Animal | 3 | CTD_human | |
Tgene | C0007097 | Carcinoma | 2 | CTD_human | |
Tgene | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human | |
Tgene | C0205696 | Anaplastic carcinoma | 2 | CTD_human | |
Tgene | C0205697 | Carcinoma, Spindle-Cell | 2 | CTD_human | |
Tgene | C0205698 | Undifferentiated carcinoma | 2 | CTD_human | |
Tgene | C0205699 | Carcinomatosis | 2 | CTD_human | |
Tgene | C0007137 | Squamous cell carcinoma | 1 | CTD_human | |
Tgene | C0020538 | Hypertensive disease | 1 | CTD_human | |
Tgene | C0022658 | Kidney Diseases | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0024232 | Lymphatic Metastasis | 1 | CTD_human | |
Tgene | C0026640 | Mouth Neoplasms | 1 | CTD_human | |
Tgene | C0027626 | Neoplasm Invasiveness | 1 | CTD_human | |
Tgene | C0027627 | Neoplasm Metastasis | 1 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0038354 | Stomach Diseases | 1 | CTD_human | |
Tgene | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human | |
Tgene | C0153381 | Malignant neoplasm of mouth | 1 | CTD_human | |
Tgene | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |