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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ACACA-RARA (FusionGDB2 ID:HG31TG5914)

Fusion Gene Summary for ACACA-RARA

Fusion gene summary

Fusion gene information	Fusion gene name: ACACA-RARA
	Fusion gene ID: hg31tg5914
		Hgene	Tgene
	Gene symbol	ACACA	RARA
	Gene ID	31	5914
	Gene name	acetyl-CoA carboxylase alpha	retinoic acid receptor alpha
	Synonyms	ACAC\|ACACAD\|ACC\|ACC1\|ACCA	NR1B1\|RAR
	Cytomap	('ACACA')('RARA') 17q12	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	acetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha	retinoic acid receptor alphaRAR-alphanuclear receptor subfamily 1 group B member 1nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long formretinoic acid nuclear receptor alpha variant 1retinoic acid nuclear receptor alpha variant 2
	Modification date	20200313	20200327
	UniProtAcc	.	P10276
	Ensembl transtripts involved in fusion gene	ENST00000353139, ENST00000394406, ENST00000416895, ENST00000588142, ENST00000335166, ENST00000360679, ENST00000361253, ENST00000589665,
Fusion gene scores	* DoF score	44 X 35 X 17=26180	29 X 39 X 17=19227
	# samples	51	55
	** MAII score	log2(51/26180*10)=-5.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(55/19227*10)=-5.12755824682814 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ACACA [Title/Abstract] AND RARA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACACA(35687113)-RARA(38487109), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RARA	GO:0007165	signal transduction	2825025
Tgene	RARA	GO:0030853	negative regulation of granulocyte differentiation	19917671
Tgene	RARA	GO:0032689	negative regulation of interferon-gamma production	18416830
Tgene	RARA	GO:0032720	negative regulation of tumor necrosis factor production	18416830
Tgene	RARA	GO:0032736	positive regulation of interleukin-13 production	18416830
Tgene	RARA	GO:0032753	positive regulation of interleukin-4 production	18416830
Tgene	RARA	GO:0032754	positive regulation of interleukin-5 production	18416830
Tgene	RARA	GO:0045630	positive regulation of T-helper 2 cell differentiation	18416830
Tgene	RARA	GO:0045892	negative regulation of transcription, DNA-templated	20080953
Tgene	RARA	GO:0045893	positive regulation of transcription, DNA-templated	18845237\|19850744\|20080953
Tgene	RARA	GO:0045944	positive regulation of transcription by RNA polymerase II	19850744\|21131358
Tgene	RARA	GO:0071300	cellular response to retinoic acid	19917671
Tgene	RARA	GO:0071391	cellular response to estrogen stimulus	20080953

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8483-01A	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
ChimerDB4	STAD	TCGA-BR-8483	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
ChimerDB4	STAD	TCGA-BR-8483	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
ChimerDB4	STAD	TCGA-BR-8680	ACACA	chr17	35687112	-	RARA	chr17	38487108	+

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Fusion Gene ORF analysis for ACACA-RARA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000353139	ENST00000254066	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000353139	ENST00000254066	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000353139	ENST00000254066	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000353139	ENST00000394089	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000353139	ENST00000394089	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000353139	ENST00000394089	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000353139	ENST00000425707	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000353139	ENST00000425707	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000353139	ENST00000425707	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000394406	ENST00000254066	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000394406	ENST00000254066	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000394406	ENST00000394089	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000394406	ENST00000394089	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000394406	ENST00000425707	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000394406	ENST00000425707	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000416895	ENST00000254066	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000416895	ENST00000254066	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000416895	ENST00000394089	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000416895	ENST00000394089	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000416895	ENST00000425707	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000416895	ENST00000425707	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000588142	ENST00000254066	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000588142	ENST00000254066	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000588142	ENST00000394089	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000588142	ENST00000394089	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-5UTR	ENST00000588142	ENST00000425707	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-5UTR	ENST00000588142	ENST00000425707	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000353139	ENST00000394081	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000353139	ENST00000394081	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000353139	ENST00000394081	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000353139	ENST00000394086	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000353139	ENST00000394086	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000353139	ENST00000394086	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000353139	ENST00000420042	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000353139	ENST00000420042	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000353139	ENST00000420042	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000394406	ENST00000394081	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000394406	ENST00000394081	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000394406	ENST00000394086	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000394406	ENST00000394086	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000394406	ENST00000420042	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000394406	ENST00000420042	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000416895	ENST00000394081	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000416895	ENST00000394081	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000416895	ENST00000394086	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000416895	ENST00000394086	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000416895	ENST00000420042	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000416895	ENST00000420042	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000588142	ENST00000394081	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000588142	ENST00000394081	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000588142	ENST00000394086	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000588142	ENST00000394086	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5CDS-intron	ENST00000588142	ENST00000420042	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
5CDS-intron	ENST00000588142	ENST00000420042	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
5UTR-5UTR	ENST00000394406	ENST00000254066	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-5UTR	ENST00000394406	ENST00000394089	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-5UTR	ENST00000394406	ENST00000425707	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-5UTR	ENST00000416895	ENST00000254066	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-5UTR	ENST00000416895	ENST00000394089	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-5UTR	ENST00000416895	ENST00000425707	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-intron	ENST00000394406	ENST00000394081	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-intron	ENST00000394406	ENST00000394086	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-intron	ENST00000394406	ENST00000420042	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-intron	ENST00000416895	ENST00000394081	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-intron	ENST00000416895	ENST00000394086	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
5UTR-intron	ENST00000416895	ENST00000420042	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000335166	ENST00000254066	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000335166	ENST00000254066	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000335166	ENST00000254066	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000335166	ENST00000394089	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000335166	ENST00000394089	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000335166	ENST00000394089	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000335166	ENST00000425707	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000335166	ENST00000425707	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000335166	ENST00000425707	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000360679	ENST00000254066	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000360679	ENST00000254066	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000360679	ENST00000254066	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000360679	ENST00000394089	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000360679	ENST00000394089	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000360679	ENST00000394089	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000360679	ENST00000425707	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000360679	ENST00000425707	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000360679	ENST00000425707	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000361253	ENST00000254066	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000361253	ENST00000254066	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000361253	ENST00000254066	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000361253	ENST00000394089	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000361253	ENST00000394089	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000361253	ENST00000394089	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000361253	ENST00000425707	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000361253	ENST00000425707	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000361253	ENST00000425707	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000588142	ENST00000254066	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000588142	ENST00000394089	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000588142	ENST00000425707	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000589665	ENST00000254066	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000589665	ENST00000254066	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000589665	ENST00000254066	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000589665	ENST00000394089	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000589665	ENST00000394089	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000589665	ENST00000394089	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000589665	ENST00000425707	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-5UTR	ENST00000589665	ENST00000425707	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-5UTR	ENST00000589665	ENST00000425707	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000335166	ENST00000394081	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000335166	ENST00000394081	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000335166	ENST00000394081	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000335166	ENST00000394086	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000335166	ENST00000394086	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000335166	ENST00000394086	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000335166	ENST00000420042	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000335166	ENST00000420042	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000335166	ENST00000420042	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000360679	ENST00000394081	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000360679	ENST00000394081	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000360679	ENST00000394081	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000360679	ENST00000394086	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000360679	ENST00000394086	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000360679	ENST00000394086	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000360679	ENST00000420042	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000360679	ENST00000420042	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000360679	ENST00000420042	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000361253	ENST00000394081	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000361253	ENST00000394081	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000361253	ENST00000394081	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000361253	ENST00000394086	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000361253	ENST00000394086	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000361253	ENST00000394086	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000361253	ENST00000420042	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000361253	ENST00000420042	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000361253	ENST00000420042	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000588142	ENST00000394081	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000588142	ENST00000394086	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000588142	ENST00000420042	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000589665	ENST00000394081	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000589665	ENST00000394081	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000589665	ENST00000394081	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000589665	ENST00000394086	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000589665	ENST00000394086	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000589665	ENST00000394086	ACACA	chr17	35687112	-	RARA	chr17	38487108	+
intron-intron	ENST00000589665	ENST00000420042	ACACA	chr17	35687113	-	RARA	chr17	38487109	+
intron-intron	ENST00000589665	ENST00000420042	ACACA	chr17	35696763	-	RARA	chr17	38487108	+
intron-intron	ENST00000589665	ENST00000420042	ACACA	chr17	35687112	-	RARA	chr17	38487108	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ACACA-RARA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ACACA	chr17	35687112	-	RARA	chr17	38487108	+	5.79E-09	1
ACACA	chr17	35687112	-	RARA	chr17	38487108	+	5.79E-09	1
ACACA	chr17	35696763	-	RARA	chr17	38487108	+	1.65E-11	1
ACACA	chr17	35687112	-	RARA	chr17	38487108	+	5.79E-09	1
ACACA	chr17	35687112	-	RARA	chr17	38487108	+	5.79E-09	1
ACACA	chr17	35696763	-	RARA	chr17	38487108	+	1.65E-11	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACACA-RARA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35687113/:38487109)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	RARA P10276
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758, PubMed:19398580). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250\|UniProtKB:P11416, ECO:0000269\|PubMed:16417524, ECO:0000269\|PubMed:19398580, ECO:0000269\|PubMed:19850744, ECO:0000269\|PubMed:20215566, ECO:0000269\|PubMed:28167758, ECO:0000269\|PubMed:9267036}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ACACA-RARA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACACA-RARA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ACACA-RARA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	RARA	P10276	DB00210	Adapalene		Small molecule	Approved
Tgene	RARA	P10276	DB00210	Adapalene		Small molecule	Approved
Tgene	RARA	P10276	DB00459	Acitretin	Agonist	Small molecule	Approved
Tgene	RARA	P10276	DB00459	Acitretin	Agonist	Small molecule	Approved
Tgene	RARA	P10276	DB00982	Isotretinoin	Other/unknown	Small molecule	Approved
Tgene	RARA	P10276	DB00982	Isotretinoin	Other/unknown	Small molecule	Approved
Tgene	RARA	P10276	DB00523	Alitretinoin	Agonist	Small molecule	Approved\|Investigational
Tgene	RARA	P10276	DB00523	Alitretinoin	Agonist	Small molecule	Approved\|Investigational
Tgene	RARA	P10276	DB00799	Tazarotene	Agonist	Small molecule	Approved\|Investigational
Tgene	RARA	P10276	DB00799	Tazarotene	Agonist	Small molecule	Approved\|Investigational
Tgene	RARA	P10276	DB12808	Trifarotene	Agonist	Small molecule	Approved\|Investigational
Tgene	RARA	P10276	DB12808	Trifarotene	Agonist	Small molecule	Approved\|Investigational
Tgene	RARA	P10276	DB00755	Tretinoin		Small molecule	Approved\|Investigational\|Nutraceutical
Tgene	RARA	P10276	DB00755	Tretinoin		Small molecule	Approved\|Investigational\|Nutraceutical

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Related Diseases for ACACA-RARA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ACACA	C0018801	Heart failure	1	CTD_human
Hgene	ACACA	C0018802	Congestive heart failure	1	CTD_human
Hgene	ACACA	C0023212	Left-Sided Heart Failure	1	CTD_human
Hgene	ACACA	C0235527	Heart Failure, Right-Sided	1	CTD_human
Hgene	ACACA	C1959583	Myocardial Failure	1	CTD_human
Hgene	ACACA	C1961112	Heart Decompensation	1	CTD_human
Hgene	ACACA	C2239176	Liver carcinoma	1	CTD_human
Tgene		C0023487	Acute Promyelocytic Leukemia	24	CTD_human;ORPHANET
Tgene		C0036341	Schizophrenia	3	PSYGENET
Tgene		C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene		C0009363	Congenital ocular coloboma (disorder)	1	GENOMICS_ENGLAND
Tgene		C0010701	Phyllodes Tumor	1	CTD_human
Tgene		C0085183	Neoplasms, Second Primary	1	CTD_human
Tgene		C0086696	Neoplasms, Therapy-Associated	1	CTD_human
Tgene		C0149940	Sciatic Neuropathy	1	CTD_human
Tgene		C0154748	Lesion of Sciatic Nerve	1	CTD_human
Tgene		C0206650	Fibroadenoma	1	CTD_human
Tgene		C0242013	Sciatic Neuritis	1	CTD_human
Tgene		C0525045	Mood Disorders	1	PSYGENET
Tgene		C0600066	Malignant Cystosarcoma Phyllodes	1	CTD_human
Tgene		C0678222	Breast Carcinoma	1	CTD_human
Tgene		C0751924	Neuralgia-Neuritis, Sciatic Nerve	1	CTD_human
Tgene		C0751925	Sciatic Nerve Palsy	1	CTD_human
Tgene		C0877578	Treatment related secondary malignancy	1	CTD_human
Tgene		C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene		C1458155	Mammary Neoplasms	1	CTD_human
Tgene		C2239176	Liver carcinoma	1	CTD_human
Tgene		C4704874	Mammary Carcinoma, Human	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ACACA-RARA (FusionGDB2 ID:HG31TG5914)

Fusion Gene Summary for ACACA-RARA

Fusion Gene ORF analysis for ACACA-RARA

Fusion Genomic Features for ACACA-RARA

Fusion Protein Features for ACACA-RARA

Fusion Gene Sequence for ACACA-RARA

Fusion Gene PPI Analysis for ACACA-RARA

Related Drugs for ACACA-RARA

Related Diseases for ACACA-RARA

Fusion Gene Studies
in Kim Lab