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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACACA-RARA (FusionGDB2 ID:HG31TG5914) |
Fusion Gene Summary for ACACA-RARA |
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Fusion gene information | Fusion gene name: ACACA-RARA | Fusion gene ID: hg31tg5914 | Hgene | Tgene | Gene symbol | ACACA | RARA | Gene ID | 31 | 5914 |
Gene name | acetyl-CoA carboxylase alpha | retinoic acid receptor alpha | |
Synonyms | ACAC|ACACAD|ACC|ACC1|ACCA | NR1B1|RAR | |
Cytomap | ('ACACA')('RARA') 17q12 | 17q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | acetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha | retinoic acid receptor alphaRAR-alphanuclear receptor subfamily 1 group B member 1nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long formretinoic acid nuclear receptor alpha variant 1retinoic acid nuclear receptor alpha variant 2 | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | P10276 | |
Ensembl transtripts involved in fusion gene | ENST00000353139, ENST00000394406, ENST00000416895, ENST00000588142, ENST00000335166, ENST00000360679, ENST00000361253, ENST00000589665, | ||
Fusion gene scores | * DoF score | 44 X 35 X 17=26180 | 29 X 39 X 17=19227 |
# samples | 51 | 55 | |
** MAII score | log2(51/26180*10)=-5.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(55/19227*10)=-5.12755824682814 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACACA [Title/Abstract] AND RARA [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACACA(35687113)-RARA(38487109), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RARA | GO:0007165 | signal transduction | 2825025 |
Tgene | RARA | GO:0030853 | negative regulation of granulocyte differentiation | 19917671 |
Tgene | RARA | GO:0032689 | negative regulation of interferon-gamma production | 18416830 |
Tgene | RARA | GO:0032720 | negative regulation of tumor necrosis factor production | 18416830 |
Tgene | RARA | GO:0032736 | positive regulation of interleukin-13 production | 18416830 |
Tgene | RARA | GO:0032753 | positive regulation of interleukin-4 production | 18416830 |
Tgene | RARA | GO:0032754 | positive regulation of interleukin-5 production | 18416830 |
Tgene | RARA | GO:0045630 | positive regulation of T-helper 2 cell differentiation | 18416830 |
Tgene | RARA | GO:0045892 | negative regulation of transcription, DNA-templated | 20080953 |
Tgene | RARA | GO:0045893 | positive regulation of transcription, DNA-templated | 18845237|19850744|20080953 |
Tgene | RARA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19850744|21131358 |
Tgene | RARA | GO:0071300 | cellular response to retinoic acid | 19917671 |
Tgene | RARA | GO:0071391 | cellular response to estrogen stimulus | 20080953 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-8483-01A | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
ChimerDB4 | STAD | TCGA-BR-8483 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
ChimerDB4 | STAD | TCGA-BR-8483 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
ChimerDB4 | STAD | TCGA-BR-8680 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
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Fusion Gene ORF analysis for ACACA-RARA |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000353139 | ENST00000254066 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000353139 | ENST00000254066 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000353139 | ENST00000254066 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000353139 | ENST00000394089 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000353139 | ENST00000394089 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000353139 | ENST00000394089 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000353139 | ENST00000425707 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000353139 | ENST00000425707 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000353139 | ENST00000425707 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000394406 | ENST00000254066 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000394406 | ENST00000254066 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000394406 | ENST00000394089 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000394406 | ENST00000394089 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000394406 | ENST00000425707 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000394406 | ENST00000425707 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000416895 | ENST00000254066 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000416895 | ENST00000254066 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000416895 | ENST00000394089 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000416895 | ENST00000394089 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000416895 | ENST00000425707 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000416895 | ENST00000425707 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000588142 | ENST00000254066 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000588142 | ENST00000254066 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000588142 | ENST00000394089 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000588142 | ENST00000394089 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-5UTR | ENST00000588142 | ENST00000425707 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-5UTR | ENST00000588142 | ENST00000425707 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000353139 | ENST00000394081 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000353139 | ENST00000394081 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000353139 | ENST00000394081 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000353139 | ENST00000394086 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000353139 | ENST00000394086 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000353139 | ENST00000394086 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000353139 | ENST00000420042 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000353139 | ENST00000420042 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000353139 | ENST00000420042 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000394406 | ENST00000394081 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000394406 | ENST00000394081 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000394406 | ENST00000394086 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000394406 | ENST00000394086 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000394406 | ENST00000420042 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000394406 | ENST00000420042 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000416895 | ENST00000394081 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000416895 | ENST00000394081 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000416895 | ENST00000394086 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000416895 | ENST00000394086 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000416895 | ENST00000420042 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000416895 | ENST00000420042 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000588142 | ENST00000394081 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000588142 | ENST00000394081 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000588142 | ENST00000394086 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000588142 | ENST00000394086 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5CDS-intron | ENST00000588142 | ENST00000420042 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
5CDS-intron | ENST00000588142 | ENST00000420042 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
5UTR-5UTR | ENST00000394406 | ENST00000254066 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-5UTR | ENST00000394406 | ENST00000394089 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-5UTR | ENST00000394406 | ENST00000425707 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-5UTR | ENST00000416895 | ENST00000254066 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-5UTR | ENST00000416895 | ENST00000394089 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-5UTR | ENST00000416895 | ENST00000425707 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-intron | ENST00000394406 | ENST00000394081 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-intron | ENST00000394406 | ENST00000394086 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-intron | ENST00000394406 | ENST00000420042 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-intron | ENST00000416895 | ENST00000394081 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-intron | ENST00000416895 | ENST00000394086 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
5UTR-intron | ENST00000416895 | ENST00000420042 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000335166 | ENST00000254066 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000335166 | ENST00000254066 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000335166 | ENST00000254066 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000335166 | ENST00000394089 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000335166 | ENST00000394089 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000335166 | ENST00000394089 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000335166 | ENST00000425707 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000335166 | ENST00000425707 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000335166 | ENST00000425707 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000360679 | ENST00000254066 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000360679 | ENST00000254066 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000360679 | ENST00000254066 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000360679 | ENST00000394089 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000360679 | ENST00000394089 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000360679 | ENST00000394089 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000360679 | ENST00000425707 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000360679 | ENST00000425707 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000360679 | ENST00000425707 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000361253 | ENST00000254066 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000361253 | ENST00000254066 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000361253 | ENST00000254066 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000361253 | ENST00000394089 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000361253 | ENST00000394089 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000361253 | ENST00000394089 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000361253 | ENST00000425707 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000361253 | ENST00000425707 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000361253 | ENST00000425707 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000588142 | ENST00000254066 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000588142 | ENST00000394089 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000588142 | ENST00000425707 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000589665 | ENST00000254066 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000589665 | ENST00000254066 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000589665 | ENST00000254066 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000589665 | ENST00000394089 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000589665 | ENST00000394089 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000589665 | ENST00000394089 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000589665 | ENST00000425707 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-5UTR | ENST00000589665 | ENST00000425707 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-5UTR | ENST00000589665 | ENST00000425707 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000335166 | ENST00000394081 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000335166 | ENST00000394081 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000335166 | ENST00000394081 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000335166 | ENST00000394086 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000335166 | ENST00000394086 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000335166 | ENST00000394086 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000335166 | ENST00000420042 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000335166 | ENST00000420042 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000335166 | ENST00000420042 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000360679 | ENST00000394081 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000360679 | ENST00000394081 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000360679 | ENST00000394081 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000360679 | ENST00000394086 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000360679 | ENST00000394086 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000360679 | ENST00000394086 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000360679 | ENST00000420042 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000360679 | ENST00000420042 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000360679 | ENST00000420042 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000361253 | ENST00000394081 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000361253 | ENST00000394081 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000361253 | ENST00000394081 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000361253 | ENST00000394086 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000361253 | ENST00000394086 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000361253 | ENST00000394086 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000361253 | ENST00000420042 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000361253 | ENST00000420042 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000361253 | ENST00000420042 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000588142 | ENST00000394081 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000588142 | ENST00000394086 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000588142 | ENST00000420042 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000589665 | ENST00000394081 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000589665 | ENST00000394081 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000589665 | ENST00000394081 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000589665 | ENST00000394086 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000589665 | ENST00000394086 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000589665 | ENST00000394086 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000589665 | ENST00000420042 | ACACA | chr17 | 35687113 | - | RARA | chr17 | 38487109 | + |
intron-intron | ENST00000589665 | ENST00000420042 | ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + |
intron-intron | ENST00000589665 | ENST00000420042 | ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ACACA-RARA |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + | 5.79E-09 | 1 |
ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + | 5.79E-09 | 1 |
ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + | 1.65E-11 | 1 |
ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + | 5.79E-09 | 1 |
ACACA | chr17 | 35687112 | - | RARA | chr17 | 38487108 | + | 5.79E-09 | 1 |
ACACA | chr17 | 35696763 | - | RARA | chr17 | 38487108 | + | 1.65E-11 | 1 |
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Fusion Protein Features for ACACA-RARA |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35687113/:38487109) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | RARA |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758, PubMed:19398580). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:9267036}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ACACA-RARA |
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Fusion Gene PPI Analysis for ACACA-RARA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACACA-RARA |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | RARA | P10276 | DB00210 | Adapalene | Small molecule | Approved | |
Tgene | RARA | P10276 | DB00210 | Adapalene | Small molecule | Approved | |
Tgene | RARA | P10276 | DB00459 | Acitretin | Agonist | Small molecule | Approved |
Tgene | RARA | P10276 | DB00459 | Acitretin | Agonist | Small molecule | Approved |
Tgene | RARA | P10276 | DB00982 | Isotretinoin | Other/unknown | Small molecule | Approved |
Tgene | RARA | P10276 | DB00982 | Isotretinoin | Other/unknown | Small molecule | Approved |
Tgene | RARA | P10276 | DB00523 | Alitretinoin | Agonist | Small molecule | Approved|Investigational |
Tgene | RARA | P10276 | DB00523 | Alitretinoin | Agonist | Small molecule | Approved|Investigational |
Tgene | RARA | P10276 | DB00799 | Tazarotene | Agonist | Small molecule | Approved|Investigational |
Tgene | RARA | P10276 | DB00799 | Tazarotene | Agonist | Small molecule | Approved|Investigational |
Tgene | RARA | P10276 | DB12808 | Trifarotene | Agonist | Small molecule | Approved|Investigational |
Tgene | RARA | P10276 | DB12808 | Trifarotene | Agonist | Small molecule | Approved|Investigational |
Tgene | RARA | P10276 | DB00755 | Tretinoin | Small molecule | Approved|Investigational|Nutraceutical | |
Tgene | RARA | P10276 | DB00755 | Tretinoin | Small molecule | Approved|Investigational|Nutraceutical |
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Related Diseases for ACACA-RARA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACACA | C0018801 | Heart failure | 1 | CTD_human |
Hgene | ACACA | C0018802 | Congestive heart failure | 1 | CTD_human |
Hgene | ACACA | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
Hgene | ACACA | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
Hgene | ACACA | C1959583 | Myocardial Failure | 1 | CTD_human |
Hgene | ACACA | C1961112 | Heart Decompensation | 1 | CTD_human |
Hgene | ACACA | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | C0023487 | Acute Promyelocytic Leukemia | 24 | CTD_human;ORPHANET | |
Tgene | C0036341 | Schizophrenia | 3 | PSYGENET | |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0009363 | Congenital ocular coloboma (disorder) | 1 | GENOMICS_ENGLAND | |
Tgene | C0010701 | Phyllodes Tumor | 1 | CTD_human | |
Tgene | C0085183 | Neoplasms, Second Primary | 1 | CTD_human | |
Tgene | C0086696 | Neoplasms, Therapy-Associated | 1 | CTD_human | |
Tgene | C0149940 | Sciatic Neuropathy | 1 | CTD_human | |
Tgene | C0154748 | Lesion of Sciatic Nerve | 1 | CTD_human | |
Tgene | C0206650 | Fibroadenoma | 1 | CTD_human | |
Tgene | C0242013 | Sciatic Neuritis | 1 | CTD_human | |
Tgene | C0525045 | Mood Disorders | 1 | PSYGENET | |
Tgene | C0600066 | Malignant Cystosarcoma Phyllodes | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C0751924 | Neuralgia-Neuritis, Sciatic Nerve | 1 | CTD_human | |
Tgene | C0751925 | Sciatic Nerve Palsy | 1 | CTD_human | |
Tgene | C0877578 | Treatment related secondary malignancy | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C2239176 | Liver carcinoma | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |