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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Fusion gene:HSP90AB1-SLC29A1 (FusionGDB2 ID:HG3326TG2030)

Fusion Gene Summary for HSP90AB1-SLC29A1

check button Fusion gene summary
Fusion gene informationFusion gene name: HSP90AB1-SLC29A1
Fusion gene ID: hg3326tg2030
HgeneTgene
Gene symbol

HSP90AB1

SLC29A1

Gene ID

3326

2030

Gene nameheat shock protein 90 alpha family class B member 1solute carrier family 29 member 1 (Augustine blood group)
SynonymsD6S182|HSP84|HSP90B|HSPC2|HSPCBENT1
Cytomap('HSP90AB1')('SLC29A1')

6p21.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein HSP 90-betaHSP90-betaheat shock 84 kDaheat shock 90kD protein 1, betaheat shock protein 90 kDaheat shock protein 90kDa alpha (cytosolic), class B member 1heat shock protein 90kDa alpha family class B member 1equilibrative nucleoside transporter 1equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporternucleoside transporter, es-typesolute carrier family 29 (equilibrative nucleoside transporter), member 1solute carrier famil
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000353801, ENST00000371646, 
ENST00000371554, 
Fusion gene scores* DoF score20 X 20 X 7=28003 X 5 X 3=45
# samples 224
** MAII scorelog2(22/2800*10)=-3.66985139830767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSP90AB1 [Title/Abstract] AND SLC29A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSP90AB1(44214932)-SLC29A1(44195000), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSP90AB1

GO:0007004

telomere maintenance via telomerase

10197982

HgeneHSP90AB1

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

24613385

HgeneHSP90AB1

GO:0031396

regulation of protein ubiquitination

16809764

HgeneHSP90AB1

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

24613385

HgeneHSP90AB1

GO:0032516

positive regulation of phosphoprotein phosphatase activity

26593036

HgeneHSP90AB1

GO:0051131

chaperone-mediated protein complex assembly

10811660

HgeneHSP90AB1

GO:0051973

positive regulation of telomerase activity

10197982

HgeneHSP90AB1

GO:1901389

negative regulation of transforming growth factor beta activation

20599762

HgeneHSP90AB1

GO:1905323

telomerase holoenzyme complex assembly

10197982

HgeneHSP90AB1

GO:2000010

positive regulation of protein localization to cell surface

23431407

TgeneSLC29A1

GO:0015858

nucleoside transport

12527552



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0WA-01AHSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
ChimerDB4BRCATCGA-BH-A0WA-01AHSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
ChimerDB4BRCATCGA-BH-A0WA-01AHSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
ChimerDB4BRCATCGA-BH-A0WA-01AHSP90AB1chr6

44214932

-SLC29A1chr6

44195000

+
ChimerDB4BRCATCGA-BH-A0WA-01AHSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
ChimerDB4BRCATCGA-BH-A0WAHSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+


Top

Fusion Gene ORF analysis for HSP90AB1-SLC29A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000353801ENST00000313248HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000353801ENST00000313248HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000313248HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000353801ENST00000313248HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000353801ENST00000313248HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371708HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000353801ENST00000371708HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371708HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000353801ENST00000371708HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000353801ENST00000371708HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371713HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000353801ENST00000371713HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371713HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000353801ENST00000371713HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000353801ENST00000371713HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371724HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000353801ENST00000371724HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371724HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000353801ENST00000371724HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000353801ENST00000371724HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371731HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000353801ENST00000371731HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371731HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000353801ENST00000371731HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000353801ENST00000371731HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371740HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000353801ENST00000371740HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371740HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000353801ENST00000371740HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000353801ENST00000371740HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371755HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000353801ENST00000371755HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000371755HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000353801ENST00000371755HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000353801ENST00000371755HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000393841HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000353801ENST00000393841HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000393841HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000353801ENST00000393841HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000353801ENST00000393841HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000393844HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000353801ENST00000393844HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000393844HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000353801ENST00000393844HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000353801ENST00000393844HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000427851HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000353801ENST00000427851HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000353801ENST00000427851HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000353801ENST00000427851HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000353801ENST00000427851HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000313248HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000371646ENST00000313248HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000313248HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000371646ENST00000313248HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000371646ENST00000313248HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371708HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000371646ENST00000371708HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371708HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000371646ENST00000371708HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000371646ENST00000371708HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371713HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000371646ENST00000371713HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371713HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000371646ENST00000371713HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000371646ENST00000371713HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371724HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000371646ENST00000371724HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371724HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000371646ENST00000371724HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000371646ENST00000371724HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371731HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000371646ENST00000371731HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371731HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000371646ENST00000371731HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000371646ENST00000371731HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371740HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000371646ENST00000371740HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371740HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000371646ENST00000371740HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000371646ENST00000371740HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371755HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000371646ENST00000371755HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000371755HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000371646ENST00000371755HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000371646ENST00000371755HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000393841HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000371646ENST00000393841HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000393841HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000371646ENST00000393841HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000371646ENST00000393841HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000393844HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000371646ENST00000393844HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000393844HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000371646ENST00000393844HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000371646ENST00000393844HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000427851HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-5UTRENST00000371646ENST00000427851HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-5UTRENST00000371646ENST00000427851HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-5UTRENST00000371646ENST00000427851HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-5UTRENST00000371646ENST00000427851HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-intronENST00000353801ENST00000472176HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-intronENST00000353801ENST00000472176HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-intronENST00000353801ENST00000472176HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-intronENST00000353801ENST00000472176HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-intronENST00000353801ENST00000472176HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
5UTR-intronENST00000371646ENST00000472176HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
5UTR-intronENST00000371646ENST00000472176HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
5UTR-intronENST00000371646ENST00000472176HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
5UTR-intronENST00000371646ENST00000472176HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
5UTR-intronENST00000371646ENST00000472176HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000313248HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-5UTRENST00000371554ENST00000313248HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000313248HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-5UTRENST00000371554ENST00000313248HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-5UTRENST00000371554ENST00000313248HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371708HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-5UTRENST00000371554ENST00000371708HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371708HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-5UTRENST00000371554ENST00000371708HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-5UTRENST00000371554ENST00000371708HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371713HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-5UTRENST00000371554ENST00000371713HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371713HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-5UTRENST00000371554ENST00000371713HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-5UTRENST00000371554ENST00000371713HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371724HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-5UTRENST00000371554ENST00000371724HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371724HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-5UTRENST00000371554ENST00000371724HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-5UTRENST00000371554ENST00000371724HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371731HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-5UTRENST00000371554ENST00000371731HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371731HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-5UTRENST00000371554ENST00000371731HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-5UTRENST00000371554ENST00000371731HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371740HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-5UTRENST00000371554ENST00000371740HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371740HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-5UTRENST00000371554ENST00000371740HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-5UTRENST00000371554ENST00000371740HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371755HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-5UTRENST00000371554ENST00000371755HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000371755HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-5UTRENST00000371554ENST00000371755HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-5UTRENST00000371554ENST00000371755HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000393841HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-5UTRENST00000371554ENST00000393841HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000393841HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-5UTRENST00000371554ENST00000393841HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-5UTRENST00000371554ENST00000393841HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000393844HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-5UTRENST00000371554ENST00000393844HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000393844HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-5UTRENST00000371554ENST00000393844HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-5UTRENST00000371554ENST00000393844HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000427851HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-5UTRENST00000371554ENST00000427851HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-5UTRENST00000371554ENST00000427851HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-5UTRENST00000371554ENST00000427851HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-5UTRENST00000371554ENST00000427851HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+
intron-intronENST00000371554ENST00000472176HSP90AB1chr6

44214931

+SLC29A1chr6

44194996

+
intron-intronENST00000371554ENST00000472176HSP90AB1chr6

44214931

+SLC29A1chr6

44194999

+
intron-intronENST00000371554ENST00000472176HSP90AB1chr6

44214932

+SLC29A1chr6

44194997

+
intron-intronENST00000371554ENST00000472176HSP90AB1chr6

44214932

+SLC29A1chr6

44195000

+
intron-intronENST00000371554ENST00000472176HSP90AB1chr6

44214932

+SLC29A1chr6

44194999

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HSP90AB1-SLC29A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HSP90AB1chr644214932+SLC29A1chr644194999+0.000720030.99928004
HSP90AB1chr644214932+SLC29A1chr644194999+0.000720030.99928004
HSP90AB1chr644214932+SLC29A1chr644194999+0.000720030.99928004
HSP90AB1chr644214932+SLC29A1chr644194999+0.000720030.99928004


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HSP90AB1-SLC29A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:44214932/:44195000)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HSP90AB1-SLC29A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HSP90AB1-SLC29A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSP90AB1-SLC29A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSP90AB1-SLC29A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSP90AB1C0019693HIV Infections1CTD_human
HgeneHSP90AB1C0033578Prostatic Neoplasms1CTD_human
HgeneHSP90AB1C0376358Malignant neoplasm of prostate1CTD_human
HgeneHSP90AB1C4505456HIV Coinfection1CTD_human
TgeneC0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneC0020179Huntington Disease1CTD_human
TgeneC0030297Pancreatic Neoplasm1CTD_human
TgeneC0346647Malignant neoplasm of pancreas1CTD_human
TgeneC0393574Huntington Disease, Late Onset1CTD_human
TgeneC0586323Alcohol Withdrawal Seizures1CTD_human
TgeneC0751207Akinetic-Rigid Variant of Huntington Disease1CTD_human
TgeneC0751208Juvenile Huntington Disease1CTD_human
TgeneC0751868Alcohol Withdrawal-Induced Major Motor Seizure1CTD_human
TgeneC0751869Status Epilepticus, Alcohol Withdrawal-Induced1CTD_human