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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:APLP1-DBH (FusionGDB2 ID:HG333TG1621)

Fusion Gene Summary for APLP1-DBH

Fusion gene summary

Fusion gene information	Fusion gene name: APLP1-DBH
	Fusion gene ID: hg333tg1621
		Hgene	Tgene
	Gene symbol	APLP1	DBH
	Gene ID	333	1621
	Gene name	amyloid beta precursor like protein 1	dopamine beta-hydroxylase
	Synonyms	APLP	DBM\|ORTHYP1
	Cytomap	('APLP1')('DBH') 19q13.12	9q34.2
	Type of gene	protein-coding	protein-coding
	Description	amyloid-like protein 1amyloid beta (A4) precursor-like protein 1amyloid precursor-like protein 1	dopamine beta-hydroxylasedopamine beta-hydroxylase (dopamine beta-monooxygenase)
	Modification date	20200313	20200313
	UniProtAcc	P51693	P09172
	Ensembl transtripts involved in fusion gene	ENST00000589298, ENST00000221891, ENST00000537454, ENST00000586861,
Fusion gene scores	* DoF score	3 X 3 X 3=27	3 X 3 X 3=27
	# samples	3	3
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: APLP1 [Title/Abstract] AND DBH [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	APLP1(36365771)-DBH(136523438), # samples:1
Anticipated loss of major functional domain due to fusion event.	APLP1-DBH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APLP1-DBH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. APLP1-DBH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. APLP1-DBH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	APLP1	GO:0071874	cellular response to norepinephrine stimulus	16531006
Hgene	APLP1	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	16531006
Tgene	DBH	GO:0042420	dopamine catabolic process	3443096\|7961964

Fusion gene breakpoints across APLP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DBH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PCPG	TCGA-SR-A6MT-01A	APLP1	chr19	36365771	+	DBH	chr9	136523438	+

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Fusion Gene ORF analysis for APLP1-DBH

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000589298	ENST00000393056	APLP1	chr19	36365771	+	DBH	chr9	136523438	+
In-frame	ENST00000221891	ENST00000393056	APLP1	chr19	36365771	+	DBH	chr9	136523438	+
In-frame	ENST00000537454	ENST00000393056	APLP1	chr19	36365771	+	DBH	chr9	136523438	+
In-frame	ENST00000586861	ENST00000393056	APLP1	chr19	36365771	+	DBH	chr9	136523438	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000537454

APLP1

chr19

36365771

ENST00000393056

DBH

chr9

136523438

2601

1572

270

1703

477

ENST00000221891

APLP1

chr19

36365771

ENST00000393056

DBH

chr9

136523438

2565

1536

192

1667

491

ENST00000586861

APLP1

chr19

36365771

ENST00000393056

DBH

chr9

136523438

2420

1391

1522

485

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000537454	ENST00000393056	APLP1	chr19	36365771	+	DBH	chr9	136523438	+	0.043739	0.956261
ENST00000221891	ENST00000393056	APLP1	chr19	36365771	+	DBH	chr9	136523438	+	0.08413941	0.9158606
ENST00000586861	ENST00000393056	APLP1	chr19	36365771	+	DBH	chr9	136523438	+	0.08219274	0.9178073

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Fusion Genomic Features for APLP1-DBH

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
APLP1	chr19	36365771	+	DBH	chr9	136523437	+	5.03E-07	0.9999995
APLP1	chr19	36365771	+	DBH	chr9	136523437	+	5.03E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for APLP1-DBH

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:36365771/chr9:136523438)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
APLP1 P51693	DBH P09172
FUNCTION: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. {ECO:0000250}.; FUNCTION: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. {ECO:0000250}.	FUNCTION: Conversion of dopamine to noradrenaline. {ECO:0000269\|PubMed:27148966, ECO:0000269\|PubMed:3443096, ECO:0000269\|PubMed:7961964, ECO:0000269\|PubMed:8546710}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

241_247

448

652.0

Compositional bias

Note=Poly-Glu

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

264_268

448

652.0

Compositional bias

Note=Poly-Glu

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

50_212

448

652.0

Domain

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

154_212

448

652.0

Region

CuBD subdomain

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

158_178

448

652.0

Region

Copper-binding

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

204_211

448

652.0

Region

Note=Zinc-binding

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

285_305

448

652.0

Region

Note=O-glycosylated at three sites

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

310_342

448

652.0

Region

Heparin-binding

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

410_441

448

652.0

Region

Heparin-binding

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

50_146

448

652.0

Region

GFLD subdomain

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

293_484

448

652.0

Domain

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

604_615

448

652.0

Motif

Basolateral sorting signal

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

640_643

448

652.0

Motif

Note=NPXY motif%3B contains endocytosis signal

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

442_459

448

652.0

Region

Collagen-binding

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

39_580

448

652.0

Topological domain

Extracellular

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

604_650

448

652.0

Topological domain

Cytoplasmic

Hgene

APLP1

chr19:36365771

chr9:136523438

ENST00000221891

581_603

448

652.0

Transmembrane

Helical

Tgene

DBH

chr19:36365771

chr9:136523438

ENST00000393056

57_173

574

618.0

Domain

DOMON

Tgene

DBH

chr19:36365771

chr9:136523438

ENST00000393056

1_16

574

618.0

Topological domain

Cytoplasmic

Tgene

DBH

chr19:36365771

chr9:136523438

ENST00000393056

38_617

574

618.0

Topological domain

Intragranular

Tgene

DBH

chr19:36365771

chr9:136523438

ENST00000393056

17_37

574

618.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for APLP1-DBH

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5437_5437_1_APLP1-DBH_APLP1_chr19_36365771_ENST00000221891_DBH_chr9_136523438_ENST00000393056_length(transcript)=2565nt_BP=1536nt
ACTCTGCGCGAAGCCGCCACGCTATTGTCCTGACCAGGAAGGCGGGGCCGGCGCGGGGCGGGGCTGGCGGCGCCGGCGCAGCCCGGGGGC
GGCGGGAGGAGGAGGTGGCGGCGGTGGCGCTGGGAGCTCCTGTCACCGCTGGGGCCGGGCCGGGCGGGAGTGCAGGGGACGTGAGGGCGC
AAGGGCCGGGACATGGGGCCCGCCAGCCCCGCTGCTCGCGGTCTAAGTCGCCGCCCGGGCCAGCCGCCGCTGCCGCTGCTGCTGCCACTA
TTGCTGCTGCTTCTGCGCGCGCAGCCCGCCATCGGGAGCCTGGCCGGTGGGAGCCCCGGCGCGGCCGAGGCCCCGGGGTCGGCCCAGGTG
GCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGG
GACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATG
GAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTG
AGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAG
GCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAG
TATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGA
GTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAA
GAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATT
TACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAAT
GAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCC
ATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGAC
CAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTAC
CTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGC
TTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGA
AGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGGACCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGG
GCTCACACCGGCACTGTGCACTCTACTCTGCGACGATCCCCATGGAACAGCCCTGCACGCCCAGGATGAAGGGGCCAGACCACGCCCCTG
CCTGAGACCACGGTCCAATCCAGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTGAGAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACC
GAGTGGACCACGACCTCGTCCATTTAAACCCGGCTGACTCAGTGCAGGGACAGCCTGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCC
CTGTTCCGCCTCACTGGGTGTGGCCTGGCTTCTGGGACAGGCACCATGCTGGGCCGGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCG
CCCCGCTGCTCCCGGTGTGCAGCGGGTGCGGGTGCCGCTTAAACATTTCCCTGCTGAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTG
CGACGGAGGCAGGACCAGGCATTTAGCTAGTTAGAGACTCGCCTGGGAAATTGCTCCATTCCTGAGTAAACAGATATTTTCGCCCACCTA
AAGGGAAGCCCTGACAACAACTATCACCAAAAGACGAGGCGGCAAAGATCCAGCGGGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAAT
TATTAGCACCAGCTTGCTTCTCTGCCGGTGGGGCCAGCGCTGAACAGACCGGGGTGGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCA
CTTAGGGAGTGTGCCTTGGGCGGGCCATTTCACATTCCTGACCCTCACTTTTCTCATCTGTAAAACCAGGCTGATGCCGTGCGGGCTAAT
GAGCCAATAAAGCTCACACTTGGGCTGGCACCCACTGGAGGTGGG

>5437_5437_1_APLP1-DBH_APLP1_chr19_36365771_ENST00000221891_DBH_chr9_136523438_ENST00000393056_length(amino acids)=491AA_BP=447
MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQR
VLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA
CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETV
PPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT
LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQGE
WNLQPLPKVISTLEEPTPQCPTSQGRSPAGPTVVSIGGGKG

--------------------------------------------------------------
>5437_5437_2_APLP1-DBH_APLP1_chr19_36365771_ENST00000537454_DBH_chr9_136523438_ENST00000393056_length(transcript)=2601nt_BP=1572nt
AATCCTGAGGTGCTGCATCCACAGTGGGCATGGTGCTGGTGCCTGCTTGGATGATCCTTAAAGAAAGGTCCTGGGGGCTTTGGTTCATGG
ATCCTTGAGCTAGGAGTTAAAGGTCCAGGCCCCTGGGACCCTTGGGAAGCAGAGCAAGAAGAGTGAACTCCTGGGTCTGAAGGAGAATGG
GCTGGGGGCTTGGTCTCTGGTCCTGAGAGAGAAGGTGCCCAGACTTCTGGATCTGAAAGAGGAAGGGACTAGGTCTCAACTGCTGCCTTC
TTGACTGGGGACATTTTGGAGGCCTGTATTCCTGAGCCCTCAACAGAGGAATGTACTAGGGGATGGGGGTCTCTGATGCTTGCATCCTTG
GAAAAGGACAAAACTGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGG
GAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATT
GCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAG
GTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATG
GACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTC
TTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGT
GACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGAT
GATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTC
ACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAG
ATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAA
GCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAA
ACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCT
CAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTG
GCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAA
GAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGG
ACCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGGGCTCACACCGGCACTGTGCACTCTACTCTGCGACGATCCCCATGGAACAGCCCT
GCACGCCCAGGATGAAGGGGCCAGACCACGCCCCTGCCTGAGACCACGGTCCAATCCAGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTG
AGAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACCGAGTGGACCACGACCTCGTCCATTTAAACCCGGCTGACTCAGTGCAGGGACAGC
CTGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCCCTGTTCCGCCTCACTGGGTGTGGCCTGGCTTCTGGGACAGGCACCATGCTGGGC
CGGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCGCCCCGCTGCTCCCGGTGTGCAGCGGGTGCGGGTGCCGCTTAAACATTTCCCTGC
TGAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTGCGACGGAGGCAGGACCAGGCATTTAGCTAGTTAGAGACTCGCCTGGGAAATTGC
TCCATTCCTGAGTAAACAGATATTTTCGCCCACCTAAAGGGAAGCCCTGACAACAACTATCACCAAAAGACGAGGCGGCAAAGATCCAGC
GGGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAATTATTAGCACCAGCTTGCTTCTCTGCCGGTGGGGCCAGCGCTGAACAGACCGGGG
TGGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCACTTAGGGAGTGTGCCTTGGGCGGGCCATTTCACATTCCTGACCCTCACTTTTCT
CATCTGTAAAACCAGGCTGATGCCGTGCGGGCTAATGAGCCAATAAAGCTCACACTTGGGCTGGCACCCACTGGAGGTGGG

>5437_5437_2_APLP1-DBH_APLP1_chr19_36365771_ENST00000537454_DBH_chr9_136523438_ENST00000393056_length(amino acids)=477AA_BP=433
MTGDILEACIPEPSTEECTRGWGSLMLASLEKDKTAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQI
ARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGML
LPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKV
TPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVE
THATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQGEWNLQPLPKVISTLE
EPTPQCPTSQGRSPAGPTVVSIGGGKG

--------------------------------------------------------------
>5437_5437_3_APLP1-DBH_APLP1_chr19_36365771_ENST00000586861_DBH_chr9_136523438_ENST00000393056_length(transcript)=2420nt_BP=1391nt
ATAGCAACGGGAGCGCTGGGGCGCCCCCGCCCTACGGGAGCTGTTTCCCAGGGAACGGTGCCTCCATGGAGGCGGTGTGCGGTGCTTGGG
GGAGGGGGCTGGTGCTGGGGGTCTCGGTCCTAGGGAGCAAAGAACCAGGGGACCCTCATGCCAACGCCCCCCGAGCCCTCACTGTCCTTT
CCACTTCCATCCAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGG
AACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTG
CACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGG
TTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGG
ACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCT
TACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTG
ACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATG
ATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCA
CTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGA
TGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAG
CCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAA
CCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTC
AGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGG
CCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCATCTCCACACTGGAAG
AGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGGA
CCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGGGCTCACACCGGCACTGTGCACTCTACTCTGCGACGATCCCCATGGAACAGCCCTG
CACGCCCAGGATGAAGGGGCCAGACCACGCCCCTGCCTGAGACCACGGTCCAATCCAGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTGA
GAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACCGAGTGGACCACGACCTCGTCCATTTAAACCCGGCTGACTCAGTGCAGGGACAGCC
TGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCCCTGTTCCGCCTCACTGGGTGTGGCCTGGCTTCTGGGACAGGCACCATGCTGGGCC
GGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCGCCCCGCTGCTCCCGGTGTGCAGCGGGTGCGGGTGCCGCTTAAACATTTCCCTGCT
GAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTGCGACGGAGGCAGGACCAGGCATTTAGCTAGTTAGAGACTCGCCTGGGAAATTGCT
CCATTCCTGAGTAAACAGATATTTTCGCCCACCTAAAGGGAAGCCCTGACAACAACTATCACCAAAAGACGAGGCGGCAAAGATCCAGCG
GGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAATTATTAGCACCAGCTTGCTTCTCTGCCGGTGGGGCCAGCGCTGAACAGACCGGGGT
GGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCACTTAGGGAGTGTGCCTTGGGCGGGCCATTTCACATTCCTGACCCTCACTTTTCTC
ATCTGTAAAACCAGGCTGATGCCGTGCGGGCTAATGAGCCAATAAAGCTCACACTTGGGCTGGCACCCACTGGAGGTGGG

>5437_5437_3_APLP1-DBH_APLP1_chr19_36365771_ENST00000586861_DBH_chr9_136523438_ENST00000393056_length(amino acids)=485AA_BP=441
MEAVCGAWGRGLVLGVSVLGSKEPGDPHANAPRALTVLSTSIQAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCR
QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGL
ILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSH
TLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVS
GERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQGEWNLQPL
PKVISTLEEPTPQCPTSQGRSPAGPTVVSIGGGKG

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Fusion Gene PPI Analysis for APLP1-DBH

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	APLP1	chr19:36365771	chr9:136523438	ENST00000221891	+	10	17	632_649	448.0	652.0	DAB1
Hgene	APLP1	chr19:36365771	chr9:136523438	ENST00000221891	+	10	17	636_650	448.0	652.0	DAB2

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for APLP1-DBH

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	APLP1	P51693	DB14548	Zinc sulfate, unspecified form	Ligand	Small molecule	Approved\|Experimental
Hgene	APLP1	P51693	DB01593	Zinc	Cofactor	Small molecule	Approved\|Investigational
Hgene	APLP1	P51693	DB09130	Copper	Cofactor	Small molecule	Approved\|Investigational
Hgene	APLP1	P51693	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Hgene	APLP1	P51693	DB14533	Zinc chloride	Ligand	Small molecule	Approved\|Investigational
Tgene	DBH	P09172	DB00822	Disulfiram	Inhibitor	Small molecule	Approved
Tgene	DBH	P09172	DB00988	Dopamine	Ligand	Small molecule	Approved
Tgene	DBH	P09172	DB00126	Ascorbic acid	Cofactor	Small molecule	Approved\|Nutraceutical

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Related Diseases for APLP1-DBH

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0001973	Alcoholic Intoxication, Chronic	5	PSYGENET
Tgene		C0005586	Bipolar Disorder	5	PSYGENET
Tgene		C0011570	Mental Depression	5	PSYGENET
Tgene		C0011581	Depressive disorder	5	PSYGENET
Tgene		C0600427	Cocaine Dependence	5	PSYGENET
Tgene		C0525045	Mood Disorders	4	PSYGENET
Tgene		C4746777	ORTHOSTATIC HYPOTENSION 1	4	GENOMICS_ENGLAND;UNIPROT
Tgene		C0041696	Unipolar Depression	3	PSYGENET
Tgene		C1269683	Major Depressive Disorder	3	PSYGENET
Tgene		C1306067	Drug-induced paranoid state	3	PSYGENET
Tgene		C1456784	Paranoia	3	CTD_human
Tgene		C0027819	Neuroblastoma	1	CTD_human
Tgene		C0031511	Pheochromocytoma	1	CTD_human
Tgene		C1257877	Pheochromocytoma, Extra-Adrenal	1	CTD_human
Tgene		C2239176	Liver carcinoma	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:APLP1-DBH (FusionGDB2 ID:HG333TG1621)

Fusion Gene Summary for APLP1-DBH

Fusion Gene ORF analysis for APLP1-DBH

Fusion Genomic Features for APLP1-DBH

Fusion Protein Features for APLP1-DBH

Fusion Gene Sequence for APLP1-DBH

Fusion Gene PPI Analysis for APLP1-DBH

Related Drugs for APLP1-DBH

Related Diseases for APLP1-DBH

Fusion Gene Studies
in Kim Lab