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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APLP2-SPCS2 (FusionGDB2 ID:HG334TG9789)

Fusion Gene Summary for APLP2-SPCS2

check button Fusion gene summary
Fusion gene informationFusion gene name: APLP2-SPCS2
Fusion gene ID: hg334tg9789
HgeneTgene
Gene symbol

APLP2

SPCS2

Gene ID

334

9789

Gene nameamyloid beta precursor like protein 2signal peptidase complex subunit 2
SynonymsAPLP-2|APPH|APPL2|CDEBP-
Cytomap('APLP2')('SPCS2')

11q24.3

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionamyloid-like protein 2CDEI box-binding proteinamyloid beta (A4) precursor-like protein 2amyloid precursor protein homolog HSD-2testicular tissue protein Li 23signal peptidase complex subunit 2SPase 25 kDa subunitmicrosomal signal peptidase 25 kDa subunitsignal peptidase 25kDa subunitsignal peptidase complex subunit 2 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263574, ENST00000278756, 
ENST00000338167, ENST00000345598, 
ENST00000528499, ENST00000539648, 
ENST00000543137, ENST00000532456, 
Fusion gene scores* DoF score32 X 25 X 10=80005 X 5 X 5=125
# samples 366
** MAII scorelog2(36/8000*10)=-4.47393118833241
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APLP2 [Title/Abstract] AND SPCS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPLP2(129997735)-SPCS2(74676079), # samples:2
Anticipated loss of major functional domain due to fusion event.APLP2-SPCS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APLP2-SPCS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APLP2-SPCS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APLP2-SPCS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across APLP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPCS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-7669-01AAPLP2chr11

129997735

+SPCS2chr11

74676079

+


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Fusion Gene ORF analysis for APLP2-SPCS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263574ENST00000526361APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-5UTRENST00000278756ENST00000526361APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-5UTRENST00000338167ENST00000526361APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-5UTRENST00000345598ENST00000526361APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-5UTRENST00000528499ENST00000526361APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-5UTRENST00000539648ENST00000526361APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-5UTRENST00000543137ENST00000526361APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-intronENST00000263574ENST00000528265APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-intronENST00000278756ENST00000528265APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-intronENST00000338167ENST00000528265APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-intronENST00000345598ENST00000528265APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-intronENST00000528499ENST00000528265APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-intronENST00000539648ENST00000528265APLP2chr11

129997735

+SPCS2chr11

74676079

+
5CDS-intronENST00000543137ENST00000528265APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000263574ENST00000263672APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000263574ENST00000530257APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000278756ENST00000263672APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000278756ENST00000530257APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000338167ENST00000263672APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000338167ENST00000530257APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000345598ENST00000263672APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000345598ENST00000530257APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000528499ENST00000263672APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000528499ENST00000530257APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000539648ENST00000263672APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000539648ENST00000530257APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000543137ENST00000263672APLP2chr11

129997735

+SPCS2chr11

74676079

+
In-frameENST00000543137ENST00000530257APLP2chr11

129997735

+SPCS2chr11

74676079

+
intron-3CDSENST00000532456ENST00000263672APLP2chr11

129997735

+SPCS2chr11

74676079

+
intron-3CDSENST00000532456ENST00000530257APLP2chr11

129997735

+SPCS2chr11

74676079

+
intron-5UTRENST00000532456ENST00000526361APLP2chr11

129997735

+SPCS2chr11

74676079

+
intron-intronENST00000532456ENST00000528265APLP2chr11

129997735

+SPCS2chr11

74676079

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000539648APLP2chr11129997735+ENST00000263672SPCS2chr1174676079+34699142121480422
ENST00000539648APLP2chr11129997735+ENST00000530257SPCS2chr1174676079+13879142121273353
ENST00000528499APLP2chr11129997735+ENST00000263672SPCS2chr1174676079+37671212841778564
ENST00000528499APLP2chr11129997735+ENST00000530257SPCS2chr1174676079+16851212841571495
ENST00000263574APLP2chr11129997735+ENST00000263672SPCS2chr1174676079+39231368721934620
ENST00000263574APLP2chr11129997735+ENST00000530257SPCS2chr1174676079+18411368721727551
ENST00000345598APLP2chr11129997735+ENST00000263672SPCS2chr1174676079+3226671621237391
ENST00000345598APLP2chr11129997735+ENST00000530257SPCS2chr1174676079+1144671621030322
ENST00000338167APLP2chr11129997735+ENST00000263672SPCS2chr1174676079+39081353571919620
ENST00000338167APLP2chr11129997735+ENST00000530257SPCS2chr1174676079+18261353571712551
ENST00000278756APLP2chr11129997735+ENST00000263672SPCS2chr1174676079+39261371451937630
ENST00000278756APLP2chr11129997735+ENST00000530257SPCS2chr1174676079+18441371451730561
ENST00000543137APLP2chr11129997735+ENST00000263672SPCS2chr1174676079+39261371451937630
ENST00000543137APLP2chr11129997735+ENST00000530257SPCS2chr1174676079+18441371451730561

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539648ENST00000263672APLP2chr11129997735+SPCS2chr1174676079+0.0001030530.9998969
ENST00000539648ENST00000530257APLP2chr11129997735+SPCS2chr1174676079+0.0005890860.99941087
ENST00000528499ENST00000263672APLP2chr11129997735+SPCS2chr1174676079+0.0001869510.999813
ENST00000528499ENST00000530257APLP2chr11129997735+SPCS2chr1174676079+0.0012394670.9987606
ENST00000263574ENST00000263672APLP2chr11129997735+SPCS2chr1174676079+0.0002193290.9997807
ENST00000263574ENST00000530257APLP2chr11129997735+SPCS2chr1174676079+0.0017926530.99820733
ENST00000345598ENST00000263672APLP2chr11129997735+SPCS2chr1174676079+0.0003432570.9996568
ENST00000345598ENST00000530257APLP2chr11129997735+SPCS2chr1174676079+0.003481250.99651873
ENST00000338167ENST00000263672APLP2chr11129997735+SPCS2chr1174676079+0.0002247140.99977535
ENST00000338167ENST00000530257APLP2chr11129997735+SPCS2chr1174676079+0.0018718610.9981281
ENST00000278756ENST00000263672APLP2chr11129997735+SPCS2chr1174676079+0.0002830860.99971694
ENST00000278756ENST00000530257APLP2chr11129997735+SPCS2chr1174676079+0.0020448940.9979551
ENST00000543137ENST00000263672APLP2chr11129997735+SPCS2chr1174676079+0.0002830860.99971694
ENST00000543137ENST00000530257APLP2chr11129997735+SPCS2chr1174676079+0.0020448940.9979551

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Fusion Genomic Features for APLP2-SPCS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
APLP2chr11129997735+SPCS2chr1174676078+0.0004944070.99950564
APLP2chr11129997735+SPCS2chr1174676078+0.0004944070.99950564

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for APLP2-SPCS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:129997735/chr11:74676079)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+918215_231432764.0Compositional biasNote=Poly-Glu
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+918215_280432764.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+917215_231442762.0Compositional biasNote=Poly-Glu
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+917215_280442762.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+917215_231432752.0Compositional biasNote=Poly-Glu
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+917215_280432752.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+816215_231376696.0Compositional biasNote=Poly-Glu
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+816215_280376696.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+918306_364432764.0DomainBPTI/Kunitz inhibitor
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+91846_205432764.0DomainE1
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+917306_364442762.0DomainBPTI/Kunitz inhibitor
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+91746_205442762.0DomainE1
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+917306_364432752.0DomainBPTI/Kunitz inhibitor
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+91746_205432752.0DomainE1
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+51346_205203523.0DomainE1
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+816306_364376696.0DomainBPTI/Kunitz inhibitor
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+81646_205376696.0DomainE1
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+918147_205432764.0RegionCuBD subdomain
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+91846_139432764.0RegionGFLD subdomain
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+917147_205442762.0RegionCuBD subdomain
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+91746_139442762.0RegionGFLD subdomain
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+917147_205432752.0RegionCuBD subdomain
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+91746_139432752.0RegionGFLD subdomain
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+513147_205203523.0RegionCuBD subdomain
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+51346_139203523.0RegionGFLD subdomain
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+816147_205376696.0RegionCuBD subdomain
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+81646_139376696.0RegionGFLD subdomain
TgeneSPCS2chr11:129997735chr11:74676079ENST0000026367205108_11138227.0Topological domainLumenal
TgeneSPCS2chr11:129997735chr11:74676079ENST0000026367205133_22638227.0Topological domainCytoplasmic
TgeneSPCS2chr11:129997735chr11:74676079ENST0000026367205112_13238227.0TransmembraneHelical
TgeneSPCS2chr11:129997735chr11:74676079ENST000002636720587_10738227.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+513215_231203523.0Compositional biasNote=Poly-Glu
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+513215_280203523.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+918373_564432764.0DomainE2
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+917373_564442762.0DomainE2
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+917373_564432752.0DomainE2
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+513306_364203523.0DomainBPTI/Kunitz inhibitor
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+513373_564203523.0DomainE2
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+816373_564376696.0DomainE2
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+918750_755432764.0MotifNote=NPXY motif
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+917750_755442762.0MotifNote=NPXY motif
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+917750_755432752.0MotifNote=NPXY motif
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+513750_755203523.0MotifNote=NPXY motif
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+816750_755376696.0MotifNote=NPXY motif
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+91832_692432764.0Topological domainExtracellular
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+918717_763432764.0Topological domainCytoplasmic
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+91732_692442762.0Topological domainExtracellular
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+917717_763442762.0Topological domainCytoplasmic
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+91732_692432752.0Topological domainExtracellular
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+917717_763432752.0Topological domainCytoplasmic
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+51332_692203523.0Topological domainExtracellular
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+513717_763203523.0Topological domainCytoplasmic
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+81632_692376696.0Topological domainExtracellular
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+816717_763376696.0Topological domainCytoplasmic
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+918693_716432764.0TransmembraneHelical
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+917693_716442762.0TransmembraneHelical
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+917693_716432752.0TransmembraneHelical
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+513693_716203523.0TransmembraneHelical
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+816693_716376696.0TransmembraneHelical
TgeneSPCS2chr11:129997735chr11:74676079ENST00000263672052_8638227.0Topological domainCytoplasmic


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Fusion Gene Sequence for APLP2-SPCS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5469_5469_1_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000263574_SPCS2_chr11_74676079_ENST00000263672_length(transcript)=3923nt_BP=1368nt
GTCGCGGTGTGCTAAGCGAGGAGTCCGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGCCACCGGGACC
GCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCT
CTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATTCAG
ACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCA
GAGCTACAGATCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGTCGC
TTTGTTACACCTTTCAAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAGCGG
ATGGAGGTGTGTGAGAATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGCATG
CTGCTCCCATGTGGGGTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAAGAG
GAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGATCTG
GAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTATGAC
ACCTTCAAAGGAGATGACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGATGTC
AAAGCTGTCTGCTCCCAGGAGGCGATGACGGGGCCCTGCCGGGCCGTGATGCCTCGTTGGTACTTCGACCTCTCCAAGGGAAAGTGCGTG
CGCTTTATATATGGTGGCTGCGGCGGCAACAGGAACAATTTTGAGTCTGAGGATTATTGTATGGCTGTGTGTAAAGCGATGATTCCTCCA
ACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAGCAG
CTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCAGAG
AGGCAGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGATGAT
TCTGCCAAAAAGGTACTTCTGGAAAAATACAAATATGTGGAGAATTTTGGTCTAATTGATGGTCGCCTCACCATCTGTACAATCTCCTGT
TTCTTTGCCATAGTGGCTTTGATTTGGGATTATATGCACCCCTTTCCAGAGTCCAAACCCGTTTTGGCTTTGTGTGTCATATCCTATTTT
GTGATGATGGGGATTCTGACCATTTATACCTCATATAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGAT
CCTGATGATATTTGGCAGCTGTCCTCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAG
CAGCAGCGGGAAGCCGAGTTCACAAAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATA
TCCAGGCTCCATGACAGTCTTGCCATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTA
GTGGCTTGGGGGGTGGGGGAGATAAAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCCTGTTTTGTCCTGAAATTTTAGT
CTATTCTGGGTAAATAGGATTTTCTGACACAGATATGAGAAGTTGTAGCTCTGATGTCTAGCTGTAGTCTCCTTGATCTGCTGATTGCAT
TATTTTAATTTGCTTTTCTGGGAAAGCAGTTTTGCTAAAAGCTGTACAGACTTTTTCTTTTGTACCTAGCAGTACTTTATATAGTATAGC
TTTGGGCCATGTAGCATTTTAAGACTCAATTTTAAAAAATTATTAATCTGTTGCTGACTCTTAATTCCTATTTCAATATGTGTTTCCTTG
AAGAATTCAGGATACAACTTCTTGTGTATGACAGCTTTCCTTCACACACTATTTTTGTGGGTGTGTATATATCTGATTTGGGAAGAATTT
AAAAAACACATAGCTTTTTAATTTGTTTGAAACAGACTTTCTGCCTGTTACATTTTTGCTTTTAACCAATTAAAGAAGCCAATGGCATTT
TAGTTTTATATTGTGTTTTCCACTAGTATATCCCTGTTGATTTGTTTGTGCCTTTTATTAACTGCCATTTTCTAAAATTTTTTTCAATAA
AAGGAAGGAAGATGTGAAAAAAATGGAGTCATAGTTTTGATGGAGAGAACAGAGAAACAAGTGTTAACATCTTTCTACTATAGGTTTTTT
TCATTTTTAGGCTATTTTACTTGTCAAAGGCCCCTGAGAACCTGTAGCTAAGGAACTCTTAGCTTTCCAGTGATAATAACAATAATAACA
ACATTCTGTACTTACTTTGTGCCAGAAATGCTCCAAGTACTTTACATGTGTTAATAATGCTCACAGCAATCCTAAGAGGCAGGTGCTGTT
ATTATCCCCATTTTACACATGAGGAAACTGAGATACAAAAGTTAAATAATTGTCACACAGCTAGTGATAGAACTGGGATTCAAACCTGGG
GAGTCCGGCTTCAGAGTTTGTGGTCCTGCAGAGACAAAACAGCCGCTTTTCCAGTATTTTCCCAGTATGGTCAGAGAAGACCTGGGTGCT
TGCCAAGATCCTTTGACCTTTAGGAATATTTCCCTACAGCCTTACAAAACATCAATTTTGGCTGAGCCTAGTACCCAACACTATATTCAG
TTTGTAAGAAATTACCATTATCACATTTCCTGTTTGTCTTGGAGAGGTTGTCCTATCTCGCACCACATGGTAGGGAATTGTGAACAACAC
TGGACAGAAAGTTAAAGCCTTGGATTCTGTACTCTTCATTCCTGTAAACCTTGGGTAAGTTTCGGAATTCTCTGTGAGCTTCTTAAAGTT
TTTGAAAGCATGTAACCGGATAAGTGTATTTTTACAATGGAGGAGTTACAGTCATCTTGGTATTTGTGGGAGATTGGTTCCAGGATCCCC
AAGCATACCAAAATCCAAGGATGCTCAAGTCCCTTATATAAAATGGTATAGCATTTGCATATAACCTACACACATCCTCCCATATACTTT
TAATCACCTCTGGATTACCTATAATACCTAATATAATGTAAATGCTATGTAAATAGTTATACTGCATTGGTTTTTTAATTTATATTTTTT
GTTATTTTTTAAAATATATTTTTAATCCATGGTTGGTTAAATCTGTAGATATAGAGGGCCAACTGTACTGTTAGACACAAGGGTCTCGAG
GCTTGCAGATAGAGACTGAATAACCCTCTCCATGATGATCCCTTAGAGTTCCCCCACTGTGCCTTTTTCTTTACATGTGCATGCAAACAT
GTGTCTCCACATACATTTTTTTTAACAAAAATTGAATTATGTTGATATATGTCCTGTAATTTGTGTTTTAAACTTAATATATCTTAGGCA
TTTTCCCTGTGTGTGTGTATAATGCAGCTATTAAAAATGAGTCTGAGGCCAGG

>5469_5469_1_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000263574_SPCS2_chr11_74676079_ENST00000263672_length(amino acids)=620AA_BP=431
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQY
CQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVED
RDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC
KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQWKIDDKPVKIDKWDGSAV
KNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRK
DPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK

--------------------------------------------------------------
>5469_5469_2_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000263574_SPCS2_chr11_74676079_ENST00000530257_length(transcript)=1841nt_BP=1368nt
GTCGCGGTGTGCTAAGCGAGGAGTCCGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGCCACCGGGACC
GCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCT
CTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATTCAG
ACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCA
GAGCTACAGATCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGTCGC
TTTGTTACACCTTTCAAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAGCGG
ATGGAGGTGTGTGAGAATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGCATG
CTGCTCCCATGTGGGGTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAAGAG
GAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGATCTG
GAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTATGAC
ACCTTCAAAGGAGATGACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGATGTC
AAAGCTGTCTGCTCCCAGGAGGCGATGACGGGGCCCTGCCGGGCCGTGATGCCTCGTTGGTACTTCGACCTCTCCAAGGGAAAGTGCGTG
CGCTTTATATATGGTGGCTGCGGCGGCAACAGGAACAATTTTGAGTCTGAGGATTATTGTATGGCTGTGTGTAAAGCGATGATTCCTCCA
ACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAGCAG
CTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCAGAG
AGGCAGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGATGAT
TCTGCCAAAAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGATCCTGATGATATTTGGCAGCTGTCCTCC
AGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAGCAGCAGCGGGAAGCCGAGTTCACAAAG
TCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATATCCAGGCTCCATGACAGTCTTGCCATA
GAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTAGTGGCTTGGGGGGTGGGGGAGATAAAA
AGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCC

>5469_5469_2_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000263574_SPCS2_chr11_74676079_ENST00000530257_length(amino acids)=551AA_BP=431
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQY
CQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVED
RDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC
KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQWKIDDKPVKIDKWDGSAV
KNSLDDSAKKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRL
HDSLAIERKIK

--------------------------------------------------------------
>5469_5469_3_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000278756_SPCS2_chr11_74676079_ENST00000263672_length(transcript)=3926nt_BP=1371nt
TTTGTTGCCAGGTGGACGCGGCCCCGGCCTTCGCGCGCGGCAGGGATGCTGCGAGCCCCGGGGGAGCTCCCGCGCCAGGCCGCCCGCTGC
TCCCTCTGCCGCCTGGGGCCGGGTCGCGGACGCGCATTTTTTAAGTGGCGCTGTTTGCCTGCGTCCGTAGACCGAGGAAACCCGCTCTGG
GCTCTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATT
CAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTAT
CCAGAGCTACAGATCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGT
CGCTTTGTTACACCTTTCAAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAG
CGGATGGAGGTGTGTGAGAATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGC
ATGCTGCTCCCATGTGGGGTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAA
GAGGAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGAT
CTGGAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTAT
GACACCTTCAAAGGAGATGACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGAT
GTCAAAGCTGTCTGCTCCCAGGAGGCGATGACGGGGCCCTGCCGGGCCGTGATGCCTCGTTGGTACTTCGACCTCTCCAAGGGAAAGTGC
GTGCGCTTTATATATGGTGGCTGCGGCGGCAACAGGAACAATTTTGAGTCTGAGGATTATTGTATGGCTGTGTGTAAAGCGATGATTCCT
CCAACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAG
CAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCA
GAGAGGCAGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGAT
GATTCTGCCAAAAAGGTACTTCTGGAAAAATACAAATATGTGGAGAATTTTGGTCTAATTGATGGTCGCCTCACCATCTGTACAATCTCC
TGTTTCTTTGCCATAGTGGCTTTGATTTGGGATTATATGCACCCCTTTCCAGAGTCCAAACCCGTTTTGGCTTTGTGTGTCATATCCTAT
TTTGTGATGATGGGGATTCTGACCATTTATACCTCATATAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATG
GATCCTGATGATATTTGGCAGCTGTCCTCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACA
AAGCAGCAGCGGGAAGCCGAGTTCACAAAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAA
ATATCCAGGCTCCATGACAGTCTTGCCATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAA
TTAGTGGCTTGGGGGGTGGGGGAGATAAAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCCTGTTTTGTCCTGAAATTTT
AGTCTATTCTGGGTAAATAGGATTTTCTGACACAGATATGAGAAGTTGTAGCTCTGATGTCTAGCTGTAGTCTCCTTGATCTGCTGATTG
CATTATTTTAATTTGCTTTTCTGGGAAAGCAGTTTTGCTAAAAGCTGTACAGACTTTTTCTTTTGTACCTAGCAGTACTTTATATAGTAT
AGCTTTGGGCCATGTAGCATTTTAAGACTCAATTTTAAAAAATTATTAATCTGTTGCTGACTCTTAATTCCTATTTCAATATGTGTTTCC
TTGAAGAATTCAGGATACAACTTCTTGTGTATGACAGCTTTCCTTCACACACTATTTTTGTGGGTGTGTATATATCTGATTTGGGAAGAA
TTTAAAAAACACATAGCTTTTTAATTTGTTTGAAACAGACTTTCTGCCTGTTACATTTTTGCTTTTAACCAATTAAAGAAGCCAATGGCA
TTTTAGTTTTATATTGTGTTTTCCACTAGTATATCCCTGTTGATTTGTTTGTGCCTTTTATTAACTGCCATTTTCTAAAATTTTTTTCAA
TAAAAGGAAGGAAGATGTGAAAAAAATGGAGTCATAGTTTTGATGGAGAGAACAGAGAAACAAGTGTTAACATCTTTCTACTATAGGTTT
TTTTCATTTTTAGGCTATTTTACTTGTCAAAGGCCCCTGAGAACCTGTAGCTAAGGAACTCTTAGCTTTCCAGTGATAATAACAATAATA
ACAACATTCTGTACTTACTTTGTGCCAGAAATGCTCCAAGTACTTTACATGTGTTAATAATGCTCACAGCAATCCTAAGAGGCAGGTGCT
GTTATTATCCCCATTTTACACATGAGGAAACTGAGATACAAAAGTTAAATAATTGTCACACAGCTAGTGATAGAACTGGGATTCAAACCT
GGGGAGTCCGGCTTCAGAGTTTGTGGTCCTGCAGAGACAAAACAGCCGCTTTTCCAGTATTTTCCCAGTATGGTCAGAGAAGACCTGGGT
GCTTGCCAAGATCCTTTGACCTTTAGGAATATTTCCCTACAGCCTTACAAAACATCAATTTTGGCTGAGCCTAGTACCCAACACTATATT
CAGTTTGTAAGAAATTACCATTATCACATTTCCTGTTTGTCTTGGAGAGGTTGTCCTATCTCGCACCACATGGTAGGGAATTGTGAACAA
CACTGGACAGAAAGTTAAAGCCTTGGATTCTGTACTCTTCATTCCTGTAAACCTTGGGTAAGTTTCGGAATTCTCTGTGAGCTTCTTAAA
GTTTTTGAAAGCATGTAACCGGATAAGTGTATTTTTACAATGGAGGAGTTACAGTCATCTTGGTATTTGTGGGAGATTGGTTCCAGGATC
CCCAAGCATACCAAAATCCAAGGATGCTCAAGTCCCTTATATAAAATGGTATAGCATTTGCATATAACCTACACACATCCTCCCATATAC
TTTTAATCACCTCTGGATTACCTATAATACCTAATATAATGTAAATGCTATGTAAATAGTTATACTGCATTGGTTTTTTAATTTATATTT
TTTGTTATTTTTTAAAATATATTTTTAATCCATGGTTGGTTAAATCTGTAGATATAGAGGGCCAACTGTACTGTTAGACACAAGGGTCTC
GAGGCTTGCAGATAGAGACTGAATAACCCTCTCCATGATGATCCCTTAGAGTTCCCCCACTGTGCCTTTTTCTTTACATGTGCATGCAAA
CATGTGTCTCCACATACATTTTTTTTAACAAAAATTGAATTATGTTGATATATGTCCTGTAATTTGTGTTTTAAACTTAATATATCTTAG
GCATTTTCCCTGTGTGTGTGTATAATGCAGCTATTAAAAATGAGTCTGAGGCCAGG

>5469_5469_3_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000278756_SPCS2_chr11_74676079_ENST00000263672_length(amino acids)=630AA_BP=441
MLRAPGELPRQAARCSLCRLGPGRGRAFFKWRCLPASVDRGNPLWALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSC
FETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVV
KEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDED
EEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNF
ESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQWKIDDKPV
KIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKE
KSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK


--------------------------------------------------------------
>5469_5469_4_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000278756_SPCS2_chr11_74676079_ENST00000530257_length(transcript)=1844nt_BP=1371nt
TTTGTTGCCAGGTGGACGCGGCCCCGGCCTTCGCGCGCGGCAGGGATGCTGCGAGCCCCGGGGGAGCTCCCGCGCCAGGCCGCCCGCTGC
TCCCTCTGCCGCCTGGGGCCGGGTCGCGGACGCGCATTTTTTAAGTGGCGCTGTTTGCCTGCGTCCGTAGACCGAGGAAACCCGCTCTGG
GCTCTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATT
CAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTAT
CCAGAGCTACAGATCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGT
CGCTTTGTTACACCTTTCAAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAG
CGGATGGAGGTGTGTGAGAATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGC
ATGCTGCTCCCATGTGGGGTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAA
GAGGAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGAT
CTGGAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTAT
GACACCTTCAAAGGAGATGACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGAT
GTCAAAGCTGTCTGCTCCCAGGAGGCGATGACGGGGCCCTGCCGGGCCGTGATGCCTCGTTGGTACTTCGACCTCTCCAAGGGAAAGTGC
GTGCGCTTTATATATGGTGGCTGCGGCGGCAACAGGAACAATTTTGAGTCTGAGGATTATTGTATGGCTGTGTGTAAAGCGATGATTCCT
CCAACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAG
CAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCA
GAGAGGCAGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGAT
GATTCTGCCAAAAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGATCCTGATGATATTTGGCAGCTGTCC
TCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAGCAGCAGCGGGAAGCCGAGTTCACA
AAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATATCCAGGCTCCATGACAGTCTTGCC
ATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTAGTGGCTTGGGGGGTGGGGGAGATA
AAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCC

>5469_5469_4_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000278756_SPCS2_chr11_74676079_ENST00000530257_length(amino acids)=561AA_BP=441
MLRAPGELPRQAARCSLCRLGPGRGRAFFKWRCLPASVDRGNPLWALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSC
FETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVV
KEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDED
EEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNF
ESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQWKIDDKPV
KIDKWDGSAVKNSLDDSAKKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVM
DAYEPEISRLHDSLAIERKIK

--------------------------------------------------------------
>5469_5469_5_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000338167_SPCS2_chr11_74676079_ENST00000263672_length(transcript)=3908nt_BP=1353nt
GCGAGGAGTCCGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGCCACCGGGACCGCGGCCGCCGCAGCC
ACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCTCTTGCAGCCAATGCC
GGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATTCAGACTGGGAAATGGGAA
CCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCAGAGCTACAGATCACA
AATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGTCGCTTTGTTACACCTTTC
AAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAGCGGATGGAGGTGTGTGAG
AATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGCATGCTGCTCCCATGTGGG
GTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAAGAGGAAGAGGAAGATGAA
GAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGATCTGGAAGACTTCACAGAA
GCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTATGACACCTTCAAAGGAGAT
GACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGATGTCAAAGCTGTCTGCTCC
CAGGAGGCGATGACGGGGCCCTGCCGGGCCGTGATGCCTCGTTGGTACTTCGACCTCTCCAAGGGAAAGTGCGTGCGCTTTATATATGGT
GGCTGCGGCGGCAACAGGAACAATTTTGAGTCTGAGGATTATTGTATGGCTGTGTGTAAAGCGATGATTCCTCCAACTCCTCTGCCAACC
AATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCAC
CGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCAGAGAGGCAGACTCTGATT
CAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGATGATTCTGCCAAAAAGGTA
CTTCTGGAAAAATACAAATATGTGGAGAATTTTGGTCTAATTGATGGTCGCCTCACCATCTGTACAATCTCCTGTTTCTTTGCCATAGTG
GCTTTGATTTGGGATTATATGCACCCCTTTCCAGAGTCCAAACCCGTTTTGGCTTTGTGTGTCATATCCTATTTTGTGATGATGGGGATT
CTGACCATTTATACCTCATATAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGATCCTGATGATATTTGG
CAGCTGTCCTCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAGCAGCAGCGGGAAGCC
GAGTTCACAAAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATATCCAGGCTCCATGAC
AGTCTTGCCATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTAGTGGCTTGGGGGGTG
GGGGAGATAAAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCCTGTTTTGTCCTGAAATTTTAGTCTATTCTGGGTAAAT
AGGATTTTCTGACACAGATATGAGAAGTTGTAGCTCTGATGTCTAGCTGTAGTCTCCTTGATCTGCTGATTGCATTATTTTAATTTGCTT
TTCTGGGAAAGCAGTTTTGCTAAAAGCTGTACAGACTTTTTCTTTTGTACCTAGCAGTACTTTATATAGTATAGCTTTGGGCCATGTAGC
ATTTTAAGACTCAATTTTAAAAAATTATTAATCTGTTGCTGACTCTTAATTCCTATTTCAATATGTGTTTCCTTGAAGAATTCAGGATAC
AACTTCTTGTGTATGACAGCTTTCCTTCACACACTATTTTTGTGGGTGTGTATATATCTGATTTGGGAAGAATTTAAAAAACACATAGCT
TTTTAATTTGTTTGAAACAGACTTTCTGCCTGTTACATTTTTGCTTTTAACCAATTAAAGAAGCCAATGGCATTTTAGTTTTATATTGTG
TTTTCCACTAGTATATCCCTGTTGATTTGTTTGTGCCTTTTATTAACTGCCATTTTCTAAAATTTTTTTCAATAAAAGGAAGGAAGATGT
GAAAAAAATGGAGTCATAGTTTTGATGGAGAGAACAGAGAAACAAGTGTTAACATCTTTCTACTATAGGTTTTTTTCATTTTTAGGCTAT
TTTACTTGTCAAAGGCCCCTGAGAACCTGTAGCTAAGGAACTCTTAGCTTTCCAGTGATAATAACAATAATAACAACATTCTGTACTTAC
TTTGTGCCAGAAATGCTCCAAGTACTTTACATGTGTTAATAATGCTCACAGCAATCCTAAGAGGCAGGTGCTGTTATTATCCCCATTTTA
CACATGAGGAAACTGAGATACAAAAGTTAAATAATTGTCACACAGCTAGTGATAGAACTGGGATTCAAACCTGGGGAGTCCGGCTTCAGA
GTTTGTGGTCCTGCAGAGACAAAACAGCCGCTTTTCCAGTATTTTCCCAGTATGGTCAGAGAAGACCTGGGTGCTTGCCAAGATCCTTTG
ACCTTTAGGAATATTTCCCTACAGCCTTACAAAACATCAATTTTGGCTGAGCCTAGTACCCAACACTATATTCAGTTTGTAAGAAATTAC
CATTATCACATTTCCTGTTTGTCTTGGAGAGGTTGTCCTATCTCGCACCACATGGTAGGGAATTGTGAACAACACTGGACAGAAAGTTAA
AGCCTTGGATTCTGTACTCTTCATTCCTGTAAACCTTGGGTAAGTTTCGGAATTCTCTGTGAGCTTCTTAAAGTTTTTGAAAGCATGTAA
CCGGATAAGTGTATTTTTACAATGGAGGAGTTACAGTCATCTTGGTATTTGTGGGAGATTGGTTCCAGGATCCCCAAGCATACCAAAATC
CAAGGATGCTCAAGTCCCTTATATAAAATGGTATAGCATTTGCATATAACCTACACACATCCTCCCATATACTTTTAATCACCTCTGGAT
TACCTATAATACCTAATATAATGTAAATGCTATGTAAATAGTTATACTGCATTGGTTTTTTAATTTATATTTTTTGTTATTTTTTAAAAT
ATATTTTTAATCCATGGTTGGTTAAATCTGTAGATATAGAGGGCCAACTGTACTGTTAGACACAAGGGTCTCGAGGCTTGCAGATAGAGA
CTGAATAACCCTCTCCATGATGATCCCTTAGAGTTCCCCCACTGTGCCTTTTTCTTTACATGTGCATGCAAACATGTGTCTCCACATACA
TTTTTTTTAACAAAAATTGAATTATGTTGATATATGTCCTGTAATTTGTGTTTTAAACTTAATATATCTTAGGCATTTTCCCTGTGTGTG
TGTATAATGCAGCTATTAAAAATGAGTCTGAGGCCAGG

>5469_5469_5_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000338167_SPCS2_chr11_74676079_ENST00000263672_length(amino acids)=620AA_BP=431
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQY
CQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVED
RDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC
KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQWKIDDKPVKIDKWDGSAV
KNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRK
DPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK

--------------------------------------------------------------
>5469_5469_6_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000338167_SPCS2_chr11_74676079_ENST00000530257_length(transcript)=1826nt_BP=1353nt
GCGAGGAGTCCGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGCCACCGGGACCGCGGCCGCCGCAGCC
ACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCTCTTGCAGCCAATGCC
GGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATTCAGACTGGGAAATGGGAA
CCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCAGAGCTACAGATCACA
AATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGTCGCTTTGTTACACCTTTC
AAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAGCGGATGGAGGTGTGTGAG
AATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGCATGCTGCTCCCATGTGGG
GTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAAGAGGAAGAGGAAGATGAA
GAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGATCTGGAAGACTTCACAGAA
GCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTATGACACCTTCAAAGGAGAT
GACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGATGTCAAAGCTGTCTGCTCC
CAGGAGGCGATGACGGGGCCCTGCCGGGCCGTGATGCCTCGTTGGTACTTCGACCTCTCCAAGGGAAAGTGCGTGCGCTTTATATATGGT
GGCTGCGGCGGCAACAGGAACAATTTTGAGTCTGAGGATTATTGTATGGCTGTGTGTAAAGCGATGATTCCTCCAACTCCTCTGCCAACC
AATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCAC
CGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCAGAGAGGCAGACTCTGATT
CAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGATGATTCTGCCAAAAAGGAG
AAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGATCCTGATGATATTTGGCAGCTGTCCTCCAGTCTTAAAAGGTTT
GATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAGCAGCAGCGGGAAGCCGAGTTCACAAAGTCCATTGCTAAGTTT
TTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATATCCAGGCTCCATGACAGTCTTGCCATAGAAAGAAAAATAAAG
TAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTAGTGGCTTGGGGGGTGGGGGAGATAAAAAGAACTTAAAATGGG
TAAAGTAAGAAATGTTAAAAAGTCCC

>5469_5469_6_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000338167_SPCS2_chr11_74676079_ENST00000530257_length(amino acids)=551AA_BP=431
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQY
CQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVED
RDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC
KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQWKIDDKPVKIDKWDGSAV
KNSLDDSAKKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRL
HDSLAIERKIK

--------------------------------------------------------------
>5469_5469_7_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000345598_SPCS2_chr11_74676079_ENST00000263672_length(transcript)=3226nt_BP=671nt
GCTAAGCGAGGAGTCCGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGCCACCGGGACCGCGGCCGCCG
CAGCCACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCTCTTGCAGCCA
ATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATTCAGACTGGGAAAT
GGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCAGAGCTACAGA
TCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGTCGCTTTGTTACAC
CTTTCAAGTGTCTCGTTCCTCCAACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTC
GCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAG
CTAAGAACCTCCCCAAAGCAGAGAGGCAGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAG
CTGTGAAAAACTCTTTGGATGATTCTGCCAAAAAGGTACTTCTGGAAAAATACAAATATGTGGAGAATTTTGGTCTAATTGATGGTCGCC
TCACCATCTGTACAATCTCCTGTTTCTTTGCCATAGTGGCTTTGATTTGGGATTATATGCACCCCTTTCCAGAGTCCAAACCCGTTTTGG
CTTTGTGTGTCATATCCTATTTTGTGATGATGGGGATTCTGACCATTTATACCTCATATAAGGAGAAGAGCATCTTTCTCGTGGCCCACA
GGAAAGATCCTACAGGAATGGATCCTGATGATATTTGGCAGCTGTCCTCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGA
CCTTCATCAGTGGGAGAACAAAGCAGCAGCGGGAAGCCGAGTTCACAAAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCA
TGGATGCATATGAGCCTGAAATATCCAGGCTCCATGACAGTCTTGCCATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCT
TTCTCCTGGATCTTGCTGAATTAGTGGCTTGGGGGGTGGGGGAGATAAAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCC
CTGTTTTGTCCTGAAATTTTAGTCTATTCTGGGTAAATAGGATTTTCTGACACAGATATGAGAAGTTGTAGCTCTGATGTCTAGCTGTAG
TCTCCTTGATCTGCTGATTGCATTATTTTAATTTGCTTTTCTGGGAAAGCAGTTTTGCTAAAAGCTGTACAGACTTTTTCTTTTGTACCT
AGCAGTACTTTATATAGTATAGCTTTGGGCCATGTAGCATTTTAAGACTCAATTTTAAAAAATTATTAATCTGTTGCTGACTCTTAATTC
CTATTTCAATATGTGTTTCCTTGAAGAATTCAGGATACAACTTCTTGTGTATGACAGCTTTCCTTCACACACTATTTTTGTGGGTGTGTA
TATATCTGATTTGGGAAGAATTTAAAAAACACATAGCTTTTTAATTTGTTTGAAACAGACTTTCTGCCTGTTACATTTTTGCTTTTAACC
AATTAAAGAAGCCAATGGCATTTTAGTTTTATATTGTGTTTTCCACTAGTATATCCCTGTTGATTTGTTTGTGCCTTTTATTAACTGCCA
TTTTCTAAAATTTTTTTCAATAAAAGGAAGGAAGATGTGAAAAAAATGGAGTCATAGTTTTGATGGAGAGAACAGAGAAACAAGTGTTAA
CATCTTTCTACTATAGGTTTTTTTCATTTTTAGGCTATTTTACTTGTCAAAGGCCCCTGAGAACCTGTAGCTAAGGAACTCTTAGCTTTC
CAGTGATAATAACAATAATAACAACATTCTGTACTTACTTTGTGCCAGAAATGCTCCAAGTACTTTACATGTGTTAATAATGCTCACAGC
AATCCTAAGAGGCAGGTGCTGTTATTATCCCCATTTTACACATGAGGAAACTGAGATACAAAAGTTAAATAATTGTCACACAGCTAGTGA
TAGAACTGGGATTCAAACCTGGGGAGTCCGGCTTCAGAGTTTGTGGTCCTGCAGAGACAAAACAGCCGCTTTTCCAGTATTTTCCCAGTA
TGGTCAGAGAAGACCTGGGTGCTTGCCAAGATCCTTTGACCTTTAGGAATATTTCCCTACAGCCTTACAAAACATCAATTTTGGCTGAGC
CTAGTACCCAACACTATATTCAGTTTGTAAGAAATTACCATTATCACATTTCCTGTTTGTCTTGGAGAGGTTGTCCTATCTCGCACCACA
TGGTAGGGAATTGTGAACAACACTGGACAGAAAGTTAAAGCCTTGGATTCTGTACTCTTCATTCCTGTAAACCTTGGGTAAGTTTCGGAA
TTCTCTGTGAGCTTCTTAAAGTTTTTGAAAGCATGTAACCGGATAAGTGTATTTTTACAATGGAGGAGTTACAGTCATCTTGGTATTTGT
GGGAGATTGGTTCCAGGATCCCCAAGCATACCAAAATCCAAGGATGCTCAAGTCCCTTATATAAAATGGTATAGCATTTGCATATAACCT
ACACACATCCTCCCATATACTTTTAATCACCTCTGGATTACCTATAATACCTAATATAATGTAAATGCTATGTAAATAGTTATACTGCAT
TGGTTTTTTAATTTATATTTTTTGTTATTTTTTAAAATATATTTTTAATCCATGGTTGGTTAAATCTGTAGATATAGAGGGCCAACTGTA
CTGTTAGACACAAGGGTCTCGAGGCTTGCAGATAGAGACTGAATAACCCTCTCCATGATGATCCCTTAGAGTTCCCCCACTGTGCCTTTT
TCTTTACATGTGCATGCAAACATGTGTCTCCACATACATTTTTTTTAACAAAAATTGAATTATGTTGATATATGTCCTGTAATTTGTGTT
TTAAACTTAATATATCTTAGGCATTTTCCCTGTGTGTGTGTATAATGCAGCTATTAAAAATGAGTCTGAGGCCAGG

>5469_5469_7_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000345598_SPCS2_chr11_74676079_ENST00000263672_length(amino acids)=391AA_BP=202
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQY
CQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVK
KEWEEAELQAKNLPKAERQTLIQWKIDDKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMH
PFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAK
FFDHSGTLVMDAYEPEISRLHDSLAIERKIK

--------------------------------------------------------------
>5469_5469_8_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000345598_SPCS2_chr11_74676079_ENST00000530257_length(transcript)=1144nt_BP=671nt
GCTAAGCGAGGAGTCCGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGCCACCGGGACCGCGGCCGCCG
CAGCCACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCTCTTGCAGCCA
ATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATTCAGACTGGGAAAT
GGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCAGAGCTACAGA
TCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGTCGCTTTGTTACAC
CTTTCAAGTGTCTCGTTCCTCCAACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTC
GCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAG
CTAAGAACCTCCCCAAAGCAGAGAGGCAGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAG
CTGTGAAAAACTCTTTGGATGATTCTGCCAAAAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGATCCTG
ATGATATTTGGCAGCTGTCCTCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAGCAGC
AGCGGGAAGCCGAGTTCACAAAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATATCCA
GGCTCCATGACAGTCTTGCCATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTAGTGG
CTTGGGGGGTGGGGGAGATAAAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCC

>5469_5469_8_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000345598_SPCS2_chr11_74676079_ENST00000530257_length(amino acids)=322AA_BP=202
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQY
CQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVK
KEWEEAELQAKNLPKAERQTLIQWKIDDKPVKIDKWDGSAVKNSLDDSAKKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKL
TFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK

--------------------------------------------------------------
>5469_5469_9_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000528499_SPCS2_chr11_74676079_ENST00000263672_length(transcript)=3767nt_BP=1212nt
AGATGCTTCTGGGTCGCGGTGTGCTAAGCGAGGAGTCCGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCG
GCCACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGC
TACATCGAGGCTCTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCAT
GTGAACATTCAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAG
GAGATGTATCCAGAGCTACAGATCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAA
TGCAAGAGTCGCTTTGTTACACCTTTCAAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTC
CACAAAGAGCGGATGGAGGTGTGTGAGAATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATAT
AGCTACGGCATGCTGCTCCCATGTGGGGTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTG
TCAAAAGAAGAGGAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACT
GAAGCAGATCTGGAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGAT
TACTACTATGACACCTTCAAAGGAGATGACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATT
ACTCATGATGTCAAAGTTCCTCCAACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCT
CGCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAA
GCTAAGAACCTCCCCAAAGCAGAGAGGCAGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCA
GCTGTGAAAAACTCTTTGGATGATTCTGCCAAAAAGGTACTTCTGGAAAAATACAAATATGTGGAGAATTTTGGTCTAATTGATGGTCGC
CTCACCATCTGTACAATCTCCTGTTTCTTTGCCATAGTGGCTTTGATTTGGGATTATATGCACCCCTTTCCAGAGTCCAAACCCGTTTTG
GCTTTGTGTGTCATATCCTATTTTGTGATGATGGGGATTCTGACCATTTATACCTCATATAAGGAGAAGAGCATCTTTCTCGTGGCCCAC
AGGAAAGATCCTACAGGAATGGATCCTGATGATATTTGGCAGCTGTCCTCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTG
ACCTTCATCAGTGGGAGAACAAAGCAGCAGCGGGAAGCCGAGTTCACAAAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTC
ATGGATGCATATGAGCCTGAAATATCCAGGCTCCATGACAGTCTTGCCATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTC
TTTCTCCTGGATCTTGCTGAATTAGTGGCTTGGGGGGTGGGGGAGATAAAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTC
CCTGTTTTGTCCTGAAATTTTAGTCTATTCTGGGTAAATAGGATTTTCTGACACAGATATGAGAAGTTGTAGCTCTGATGTCTAGCTGTA
GTCTCCTTGATCTGCTGATTGCATTATTTTAATTTGCTTTTCTGGGAAAGCAGTTTTGCTAAAAGCTGTACAGACTTTTTCTTTTGTACC
TAGCAGTACTTTATATAGTATAGCTTTGGGCCATGTAGCATTTTAAGACTCAATTTTAAAAAATTATTAATCTGTTGCTGACTCTTAATT
CCTATTTCAATATGTGTTTCCTTGAAGAATTCAGGATACAACTTCTTGTGTATGACAGCTTTCCTTCACACACTATTTTTGTGGGTGTGT
ATATATCTGATTTGGGAAGAATTTAAAAAACACATAGCTTTTTAATTTGTTTGAAACAGACTTTCTGCCTGTTACATTTTTGCTTTTAAC
CAATTAAAGAAGCCAATGGCATTTTAGTTTTATATTGTGTTTTCCACTAGTATATCCCTGTTGATTTGTTTGTGCCTTTTATTAACTGCC
ATTTTCTAAAATTTTTTTCAATAAAAGGAAGGAAGATGTGAAAAAAATGGAGTCATAGTTTTGATGGAGAGAACAGAGAAACAAGTGTTA
ACATCTTTCTACTATAGGTTTTTTTCATTTTTAGGCTATTTTACTTGTCAAAGGCCCCTGAGAACCTGTAGCTAAGGAACTCTTAGCTTT
CCAGTGATAATAACAATAATAACAACATTCTGTACTTACTTTGTGCCAGAAATGCTCCAAGTACTTTACATGTGTTAATAATGCTCACAG
CAATCCTAAGAGGCAGGTGCTGTTATTATCCCCATTTTACACATGAGGAAACTGAGATACAAAAGTTAAATAATTGTCACACAGCTAGTG
ATAGAACTGGGATTCAAACCTGGGGAGTCCGGCTTCAGAGTTTGTGGTCCTGCAGAGACAAAACAGCCGCTTTTCCAGTATTTTCCCAGT
ATGGTCAGAGAAGACCTGGGTGCTTGCCAAGATCCTTTGACCTTTAGGAATATTTCCCTACAGCCTTACAAAACATCAATTTTGGCTGAG
CCTAGTACCCAACACTATATTCAGTTTGTAAGAAATTACCATTATCACATTTCCTGTTTGTCTTGGAGAGGTTGTCCTATCTCGCACCAC
ATGGTAGGGAATTGTGAACAACACTGGACAGAAAGTTAAAGCCTTGGATTCTGTACTCTTCATTCCTGTAAACCTTGGGTAAGTTTCGGA
ATTCTCTGTGAGCTTCTTAAAGTTTTTGAAAGCATGTAACCGGATAAGTGTATTTTTACAATGGAGGAGTTACAGTCATCTTGGTATTTG
TGGGAGATTGGTTCCAGGATCCCCAAGCATACCAAAATCCAAGGATGCTCAAGTCCCTTATATAAAATGGTATAGCATTTGCATATAACC
TACACACATCCTCCCATATACTTTTAATCACCTCTGGATTACCTATAATACCTAATATAATGTAAATGCTATGTAAATAGTTATACTGCA
TTGGTTTTTTAATTTATATTTTTTGTTATTTTTTAAAATATATTTTTAATCCATGGTTGGTTAAATCTGTAGATATAGAGGGCCAACTGT
ACTGTTAGACACAAGGGTCTCGAGGCTTGCAGATAGAGACTGAATAACCCTCTCCATGATGATCCCTTAGAGTTCCCCCACTGTGCCTTT
TTCTTTACATGTGCATGCAAACATGTGTCTCCACATACATTTTTTTTAACAAAAATTGAATTATGTTGATATATGTCCTGTAATTTGTGT
TTTAAACTTAATATATCTTAGGCATTTTCCCTGTGTGTGTGTATAATGCAGCTATTAAAAATGAGTCTGAGGCCAGG

>5469_5469_9_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000528499_SPCS2_chr11_74676079_ENST00000263672_length(amino acids)=564AA_BP=375
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQY
CQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVED
RDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
LQAKNLPKAERQTLIQWKIDDKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKP
VLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGT
LVMDAYEPEISRLHDSLAIERKIK

--------------------------------------------------------------
>5469_5469_10_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000528499_SPCS2_chr11_74676079_ENST00000530257_length(transcript)=1685nt_BP=1212nt
AGATGCTTCTGGGTCGCGGTGTGCTAAGCGAGGAGTCCGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCG
GCCACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGC
TACATCGAGGCTCTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCAT
GTGAACATTCAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAG
GAGATGTATCCAGAGCTACAGATCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAA
TGCAAGAGTCGCTTTGTTACACCTTTCAAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTC
CACAAAGAGCGGATGGAGGTGTGTGAGAATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATAT
AGCTACGGCATGCTGCTCCCATGTGGGGTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTG
TCAAAAGAAGAGGAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACT
GAAGCAGATCTGGAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGAT
TACTACTATGACACCTTCAAAGGAGATGACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATT
ACTCATGATGTCAAAGTTCCTCCAACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCT
CGCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAA
GCTAAGAACCTCCCCAAAGCAGAGAGGCAGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCA
GCTGTGAAAAACTCTTTGGATGATTCTGCCAAAAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGATCCT
GATGATATTTGGCAGCTGTCCTCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAGCAG
CAGCGGGAAGCCGAGTTCACAAAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATATCC
AGGCTCCATGACAGTCTTGCCATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTAGTG
GCTTGGGGGGTGGGGGAGATAAAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCC

>5469_5469_10_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000528499_SPCS2_chr11_74676079_ENST00000530257_length(amino acids)=495AA_BP=375
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQY
CQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVED
RDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
LQAKNLPKAERQTLIQWKIDDKPVKIDKWDGSAVKNSLDDSAKKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRT
KQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK

--------------------------------------------------------------
>5469_5469_11_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000539648_SPCS2_chr11_74676079_ENST00000263672_length(transcript)=3469nt_BP=914nt
AGATGCTTCTGGGTCGCGGTGTGCTAAGCGAGGAGTCCGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCG
GCCACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGC
TACATCGAGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAGCGGATGGAGGTGTGTGAGA
ATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGCATGCTGCTCCCATGTGGGG
TAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAAGAGGAAGAGGAAGATGAAG
AGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGATCTGGAAGACTTCACAGAAG
CAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTATGACACCTTCAAAGGAGATG
ACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGATGTCAAAGTTCCTCCAACTC
CTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAGCAGCTGG
AGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCAGAGAGGC
AGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGATGATTCTG
CCAAAAAGGTACTTCTGGAAAAATACAAATATGTGGAGAATTTTGGTCTAATTGATGGTCGCCTCACCATCTGTACAATCTCCTGTTTCT
TTGCCATAGTGGCTTTGATTTGGGATTATATGCACCCCTTTCCAGAGTCCAAACCCGTTTTGGCTTTGTGTGTCATATCCTATTTTGTGA
TGATGGGGATTCTGACCATTTATACCTCATATAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGATCCTG
ATGATATTTGGCAGCTGTCCTCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAGCAGC
AGCGGGAAGCCGAGTTCACAAAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATATCCA
GGCTCCATGACAGTCTTGCCATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTAGTGG
CTTGGGGGGTGGGGGAGATAAAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCCTGTTTTGTCCTGAAATTTTAGTCTAT
TCTGGGTAAATAGGATTTTCTGACACAGATATGAGAAGTTGTAGCTCTGATGTCTAGCTGTAGTCTCCTTGATCTGCTGATTGCATTATT
TTAATTTGCTTTTCTGGGAAAGCAGTTTTGCTAAAAGCTGTACAGACTTTTTCTTTTGTACCTAGCAGTACTTTATATAGTATAGCTTTG
GGCCATGTAGCATTTTAAGACTCAATTTTAAAAAATTATTAATCTGTTGCTGACTCTTAATTCCTATTTCAATATGTGTTTCCTTGAAGA
ATTCAGGATACAACTTCTTGTGTATGACAGCTTTCCTTCACACACTATTTTTGTGGGTGTGTATATATCTGATTTGGGAAGAATTTAAAA
AACACATAGCTTTTTAATTTGTTTGAAACAGACTTTCTGCCTGTTACATTTTTGCTTTTAACCAATTAAAGAAGCCAATGGCATTTTAGT
TTTATATTGTGTTTTCCACTAGTATATCCCTGTTGATTTGTTTGTGCCTTTTATTAACTGCCATTTTCTAAAATTTTTTTCAATAAAAGG
AAGGAAGATGTGAAAAAAATGGAGTCATAGTTTTGATGGAGAGAACAGAGAAACAAGTGTTAACATCTTTCTACTATAGGTTTTTTTCAT
TTTTAGGCTATTTTACTTGTCAAAGGCCCCTGAGAACCTGTAGCTAAGGAACTCTTAGCTTTCCAGTGATAATAACAATAATAACAACAT
TCTGTACTTACTTTGTGCCAGAAATGCTCCAAGTACTTTACATGTGTTAATAATGCTCACAGCAATCCTAAGAGGCAGGTGCTGTTATTA
TCCCCATTTTACACATGAGGAAACTGAGATACAAAAGTTAAATAATTGTCACACAGCTAGTGATAGAACTGGGATTCAAACCTGGGGAGT
CCGGCTTCAGAGTTTGTGGTCCTGCAGAGACAAAACAGCCGCTTTTCCAGTATTTTCCCAGTATGGTCAGAGAAGACCTGGGTGCTTGCC
AAGATCCTTTGACCTTTAGGAATATTTCCCTACAGCCTTACAAAACATCAATTTTGGCTGAGCCTAGTACCCAACACTATATTCAGTTTG
TAAGAAATTACCATTATCACATTTCCTGTTTGTCTTGGAGAGGTTGTCCTATCTCGCACCACATGGTAGGGAATTGTGAACAACACTGGA
CAGAAAGTTAAAGCCTTGGATTCTGTACTCTTCATTCCTGTAAACCTTGGGTAAGTTTCGGAATTCTCTGTGAGCTTCTTAAAGTTTTTG
AAAGCATGTAACCGGATAAGTGTATTTTTACAATGGAGGAGTTACAGTCATCTTGGTATTTGTGGGAGATTGGTTCCAGGATCCCCAAGC
ATACCAAAATCCAAGGATGCTCAAGTCCCTTATATAAAATGGTATAGCATTTGCATATAACCTACACACATCCTCCCATATACTTTTAAT
CACCTCTGGATTACCTATAATACCTAATATAATGTAAATGCTATGTAAATAGTTATACTGCATTGGTTTTTTAATTTATATTTTTTGTTA
TTTTTTAAAATATATTTTTAATCCATGGTTGGTTAAATCTGTAGATATAGAGGGCCAACTGTACTGTTAGACACAAGGGTCTCGAGGCTT
GCAGATAGAGACTGAATAACCCTCTCCATGATGATCCCTTAGAGTTCCCCCACTGTGCCTTTTTCTTTACATGTGCATGCAAACATGTGT
CTCCACATACATTTTTTTTAACAAAAATTGAATTATGTTGATATATGTCCTGTAATTTGTGTTTTAAACTTAATATATCTTAGGCATTTT
CCCTGTGTGTGTGTATAATGCAGCTATTAAAAATGAGTCTGAGGCCAGG

>5469_5469_11_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000539648_SPCS2_chr11_74676079_ENST00000263672_length(amino acids)=422AA_BP=233
MLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEED
YDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYF
ETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQWKIDDKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKY
VENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLK
RFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK

--------------------------------------------------------------
>5469_5469_12_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000539648_SPCS2_chr11_74676079_ENST00000530257_length(transcript)=1387nt_BP=914nt
AGATGCTTCTGGGTCGCGGTGTGCTAAGCGAGGAGTCCGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCG
GCCACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGC
TACATCGAGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAGCGGATGGAGGTGTGTGAGA
ATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGCATGCTGCTCCCATGTGGGG
TAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAAGAGGAAGAGGAAGATGAAG
AGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGATCTGGAAGACTTCACAGAAG
CAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTATGACACCTTCAAAGGAGATG
ACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGATGTCAAAGTTCCTCCAACTC
CTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAGCAGCTGG
AGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCAGAGAGGC
AGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGATGATTCTG
CCAAAAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGATCCTGATGATATTTGGCAGCTGTCCTCCAGTC
TTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAGCAGCAGCGGGAAGCCGAGTTCACAAAGTCCA
TTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATATCCAGGCTCCATGACAGTCTTGCCATAGAAA
GAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTAGTGGCTTGGGGGGTGGGGGAGATAAAAAGAA
CTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCC

>5469_5469_12_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000539648_SPCS2_chr11_74676079_ENST00000530257_length(amino acids)=353AA_BP=233
MLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEED
YDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYF
ETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQWKIDDKPVKIDKWDGSAVKNSLDDSAKKEKSIFLVA
HRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK

--------------------------------------------------------------
>5469_5469_13_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000543137_SPCS2_chr11_74676079_ENST00000263672_length(transcript)=3926nt_BP=1371nt
TTTGTTGCCAGGTGGACGCGGCCCCGGCCTTCGCGCGCGGCAGGGATGCTGCGAGCCCCGGGGGAGCTCCCGCGCCAGGCCGCCCGCTGC
TCCCTCTGCCGCCTGGGGCCGGGTCGCGGACGCGCATTTTTTAAGTGGCGCTGTTTGCCTGCGTCCGTAGACCGAGGAAACCCGCTCTGG
GCTCTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATT
CAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTAT
CCAGAGCTACAGATCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGT
CGCTTTGTTACACCTTTCAAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAG
CGGATGGAGGTGTGTGAGAATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGC
ATGCTGCTCCCATGTGGGGTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAA
GAGGAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGAT
CTGGAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTAT
GACACCTTCAAAGGAGATGACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGAT
GTCAAAGCTGTCTGCTCCCAGGAGGCGATGACGGGGCCCTGCCGGGCCGTGATGCCTCGTTGGTACTTCGACCTCTCCAAGGGAAAGTGC
GTGCGCTTTATATATGGTGGCTGCGGCGGCAACAGGAACAATTTTGAGTCTGAGGATTATTGTATGGCTGTGTGTAAAGCGATGATTCCT
CCAACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAG
CAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCA
GAGAGGCAGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGAT
GATTCTGCCAAAAAGGTACTTCTGGAAAAATACAAATATGTGGAGAATTTTGGTCTAATTGATGGTCGCCTCACCATCTGTACAATCTCC
TGTTTCTTTGCCATAGTGGCTTTGATTTGGGATTATATGCACCCCTTTCCAGAGTCCAAACCCGTTTTGGCTTTGTGTGTCATATCCTAT
TTTGTGATGATGGGGATTCTGACCATTTATACCTCATATAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATG
GATCCTGATGATATTTGGCAGCTGTCCTCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACA
AAGCAGCAGCGGGAAGCCGAGTTCACAAAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAA
ATATCCAGGCTCCATGACAGTCTTGCCATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAA
TTAGTGGCTTGGGGGGTGGGGGAGATAAAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCCTGTTTTGTCCTGAAATTTT
AGTCTATTCTGGGTAAATAGGATTTTCTGACACAGATATGAGAAGTTGTAGCTCTGATGTCTAGCTGTAGTCTCCTTGATCTGCTGATTG
CATTATTTTAATTTGCTTTTCTGGGAAAGCAGTTTTGCTAAAAGCTGTACAGACTTTTTCTTTTGTACCTAGCAGTACTTTATATAGTAT
AGCTTTGGGCCATGTAGCATTTTAAGACTCAATTTTAAAAAATTATTAATCTGTTGCTGACTCTTAATTCCTATTTCAATATGTGTTTCC
TTGAAGAATTCAGGATACAACTTCTTGTGTATGACAGCTTTCCTTCACACACTATTTTTGTGGGTGTGTATATATCTGATTTGGGAAGAA
TTTAAAAAACACATAGCTTTTTAATTTGTTTGAAACAGACTTTCTGCCTGTTACATTTTTGCTTTTAACCAATTAAAGAAGCCAATGGCA
TTTTAGTTTTATATTGTGTTTTCCACTAGTATATCCCTGTTGATTTGTTTGTGCCTTTTATTAACTGCCATTTTCTAAAATTTTTTTCAA
TAAAAGGAAGGAAGATGTGAAAAAAATGGAGTCATAGTTTTGATGGAGAGAACAGAGAAACAAGTGTTAACATCTTTCTACTATAGGTTT
TTTTCATTTTTAGGCTATTTTACTTGTCAAAGGCCCCTGAGAACCTGTAGCTAAGGAACTCTTAGCTTTCCAGTGATAATAACAATAATA
ACAACATTCTGTACTTACTTTGTGCCAGAAATGCTCCAAGTACTTTACATGTGTTAATAATGCTCACAGCAATCCTAAGAGGCAGGTGCT
GTTATTATCCCCATTTTACACATGAGGAAACTGAGATACAAAAGTTAAATAATTGTCACACAGCTAGTGATAGAACTGGGATTCAAACCT
GGGGAGTCCGGCTTCAGAGTTTGTGGTCCTGCAGAGACAAAACAGCCGCTTTTCCAGTATTTTCCCAGTATGGTCAGAGAAGACCTGGGT
GCTTGCCAAGATCCTTTGACCTTTAGGAATATTTCCCTACAGCCTTACAAAACATCAATTTTGGCTGAGCCTAGTACCCAACACTATATT
CAGTTTGTAAGAAATTACCATTATCACATTTCCTGTTTGTCTTGGAGAGGTTGTCCTATCTCGCACCACATGGTAGGGAATTGTGAACAA
CACTGGACAGAAAGTTAAAGCCTTGGATTCTGTACTCTTCATTCCTGTAAACCTTGGGTAAGTTTCGGAATTCTCTGTGAGCTTCTTAAA
GTTTTTGAAAGCATGTAACCGGATAAGTGTATTTTTACAATGGAGGAGTTACAGTCATCTTGGTATTTGTGGGAGATTGGTTCCAGGATC
CCCAAGCATACCAAAATCCAAGGATGCTCAAGTCCCTTATATAAAATGGTATAGCATTTGCATATAACCTACACACATCCTCCCATATAC
TTTTAATCACCTCTGGATTACCTATAATACCTAATATAATGTAAATGCTATGTAAATAGTTATACTGCATTGGTTTTTTAATTTATATTT
TTTGTTATTTTTTAAAATATATTTTTAATCCATGGTTGGTTAAATCTGTAGATATAGAGGGCCAACTGTACTGTTAGACACAAGGGTCTC
GAGGCTTGCAGATAGAGACTGAATAACCCTCTCCATGATGATCCCTTAGAGTTCCCCCACTGTGCCTTTTTCTTTACATGTGCATGCAAA
CATGTGTCTCCACATACATTTTTTTTAACAAAAATTGAATTATGTTGATATATGTCCTGTAATTTGTGTTTTAAACTTAATATATCTTAG
GCATTTTCCCTGTGTGTGTGTATAATGCAGCTATTAAAAATGAGTCTGAGGCCAGG

>5469_5469_13_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000543137_SPCS2_chr11_74676079_ENST00000263672_length(amino acids)=630AA_BP=441
MLRAPGELPRQAARCSLCRLGPGRGRAFFKWRCLPASVDRGNPLWALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSC
FETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVV
KEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDED
EEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNF
ESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQWKIDDKPV
KIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKE
KSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK


--------------------------------------------------------------
>5469_5469_14_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000543137_SPCS2_chr11_74676079_ENST00000530257_length(transcript)=1844nt_BP=1371nt
TTTGTTGCCAGGTGGACGCGGCCCCGGCCTTCGCGCGCGGCAGGGATGCTGCGAGCCCCGGGGGAGCTCCCGCGCCAGGCCGCCCGCTGC
TCCCTCTGCCGCCTGGGGCCGGGTCGCGGACGCGCATTTTTTAAGTGGCGCTGTTTGCCTGCGTCCGTAGACCGAGGAAACCCGCTCTGG
GCTCTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATT
CAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTAT
CCAGAGCTACAGATCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGT
CGCTTTGTTACACCTTTCAAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAG
CGGATGGAGGTGTGTGAGAATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGC
ATGCTGCTCCCATGTGGGGTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAA
GAGGAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGAT
CTGGAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTAT
GACACCTTCAAAGGAGATGACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGAT
GTCAAAGCTGTCTGCTCCCAGGAGGCGATGACGGGGCCCTGCCGGGCCGTGATGCCTCGTTGGTACTTCGACCTCTCCAAGGGAAAGTGC
GTGCGCTTTATATATGGTGGCTGCGGCGGCAACAGGAACAATTTTGAGTCTGAGGATTATTGTATGGCTGTGTGTAAAGCGATGATTCCT
CCAACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAG
CAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCA
GAGAGGCAGACTCTGATTCAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGAT
GATTCTGCCAAAAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGATCCTGATGATATTTGGCAGCTGTCC
TCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAGCAGCAGCGGGAAGCCGAGTTCACA
AAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATATCCAGGCTCCATGACAGTCTTGCC
ATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTAGTGGCTTGGGGGGTGGGGGAGATA
AAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCC

>5469_5469_14_APLP2-SPCS2_APLP2_chr11_129997735_ENST00000543137_SPCS2_chr11_74676079_ENST00000530257_length(amino acids)=561AA_BP=441
MLRAPGELPRQAARCSLCRLGPGRGRAFFKWRCLPASVDRGNPLWALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSC
FETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVV
KEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDED
EEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNF
ESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQWKIDDKPV
KIDKWDGSAVKNSLDDSAKKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVM
DAYEPEISRLHDSLAIERKIK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for APLP2-SPCS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAPLP2chr11:129997735chr11:74676079ENST00000263574+918749_763432.0764.0DAB2
HgeneAPLP2chr11:129997735chr11:74676079ENST00000278756+917749_763442.0762.0DAB2
HgeneAPLP2chr11:129997735chr11:74676079ENST00000338167+917749_763432.0752.0DAB2
HgeneAPLP2chr11:129997735chr11:74676079ENST00000345598+513749_763203.0523.0DAB2
HgeneAPLP2chr11:129997735chr11:74676079ENST00000528499+816749_763376.0696.0DAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APLP2-SPCS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APLP2-SPCS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPLP2C0027746Nerve Degeneration1CTD_human
HgeneAPLP2C0151744Myocardial Ischemia1CTD_human