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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:APOA1-FARP1 (FusionGDB2 ID:HG335TG10160) |
Fusion Gene Summary for APOA1-FARP1 |
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Fusion gene information | Fusion gene name: APOA1-FARP1 | Fusion gene ID: hg335tg10160 | Hgene | Tgene | Gene symbol | APOA1 | FARP1 | Gene ID | 335 | 10160 |
Gene name | apolipoprotein A1 | FERM, ARH/RhoGEF and pleckstrin domain protein 1 | |
Synonyms | HPALP2|apo(a) | CDEP|FARP1-IT1|PLEKHC2|PPP1R75 | |
Cytomap | ('APOA1')('FARP1') 11q23.3 | 13q32.2 | |
Type of gene | protein-coding | protein-coding | |
Description | apolipoprotein A-Iapo-AIepididymis secretory sperm binding protein | FERM, ARHGEF and pleckstrin domain-containing protein 1FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)FERM, RhoGEF and pleckstrin domain-containing protein 1PH domain-containing family C member 2chondrocyte-derived ezrin-li | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | P02647 | . | |
Ensembl transtripts involved in fusion gene | ENST00000236850, ENST00000359492, ENST00000375320, ENST00000375323, ENST00000375329, | ||
Fusion gene scores | * DoF score | 9 X 5 X 3=135 | 19 X 19 X 8=2888 |
# samples | 9 | 22 | |
** MAII score | log2(9/135*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/2888*10)=-3.71449531336251 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: APOA1 [Title/Abstract] AND FARP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | APOA1(116706808)-FARP1(99087897), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | APOA1 | GO:0002740 | negative regulation of cytokine secretion involved in immune response | 12458630 |
Hgene | APOA1 | GO:0006656 | phosphatidylcholine biosynthetic process | 4335615 |
Hgene | APOA1 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 23726972 |
Hgene | APOA1 | GO:0007186 | G protein-coupled receptor signaling pathway | 16443932 |
Hgene | APOA1 | GO:0007229 | integrin-mediated signaling pathway | 23726972 |
Hgene | APOA1 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 21571275 |
Hgene | APOA1 | GO:0010873 | positive regulation of cholesterol esterification | 4335615 |
Hgene | APOA1 | GO:0010875 | positive regulation of cholesterol efflux | 27472885 |
Hgene | APOA1 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling | 14967812 |
Hgene | APOA1 | GO:0018158 | protein oxidation | 12576517 |
Hgene | APOA1 | GO:0018206 | peptidyl-methionine modification | 12576517 |
Hgene | APOA1 | GO:0030301 | cholesterol transport | 10559507 |
Hgene | APOA1 | GO:0032489 | regulation of Cdc42 protein signal transduction | 16443932 |
Hgene | APOA1 | GO:0033344 | cholesterol efflux | 11162594|14703508|15358760|16443932|21481393 |
Hgene | APOA1 | GO:0033700 | phospholipid efflux | 11162594|14703508 |
Hgene | APOA1 | GO:0034115 | negative regulation of heterotypic cell-cell adhesion | 21571275 |
Hgene | APOA1 | GO:0034375 | high-density lipoprotein particle remodeling | 21481393 |
Hgene | APOA1 | GO:0034380 | high-density lipoprotein particle assembly | 190223 |
Hgene | APOA1 | GO:0035025 | positive regulation of Rho protein signal transduction | 23726972 |
Hgene | APOA1 | GO:0042632 | cholesterol homeostasis | 21571275 |
Hgene | APOA1 | GO:0050713 | negative regulation of interleukin-1 beta secretion | 12458630 |
Hgene | APOA1 | GO:0050728 | negative regulation of inflammatory response | 21571275 |
Hgene | APOA1 | GO:0050766 | positive regulation of phagocytosis | 20495215 |
Hgene | APOA1 | GO:0050821 | protein stabilization | 17655203|20495215 |
Hgene | APOA1 | GO:0050919 | negative chemotaxis | 23726972 |
Hgene | APOA1 | GO:0051345 | positive regulation of hydrolase activity | 7638166 |
Hgene | APOA1 | GO:0051496 | positive regulation of stress fiber assembly | 23726972 |
Hgene | APOA1 | GO:0055091 | phospholipid homeostasis | 21571275 |
Hgene | APOA1 | GO:0060354 | negative regulation of cell adhesion molecule production | 21571275 |
Hgene | APOA1 | GO:0060761 | negative regulation of response to cytokine stimulus | 21571275 |
Hgene | APOA1 | GO:0070328 | triglyceride homeostasis | 21571275 |
Hgene | APOA1 | GO:0070371 | ERK1 and ERK2 cascade | 23726972 |
Hgene | APOA1 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 23726972 |
Hgene | APOA1 | GO:1902995 | positive regulation of phospholipid efflux | 27472885 |
Tgene | FARP1 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LIHC | TCGA-RC-A7S9-01A | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
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Fusion Gene ORF analysis for APOA1-FARP1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000236850 | ENST00000319562 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000236850 | ENST00000376586 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000236850 | ENST00000595437 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000359492 | ENST00000319562 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000359492 | ENST00000376586 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000359492 | ENST00000595437 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000375320 | ENST00000319562 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000375320 | ENST00000376586 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000375320 | ENST00000595437 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000375323 | ENST00000319562 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000375323 | ENST00000376586 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000375323 | ENST00000595437 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000375329 | ENST00000319562 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000375329 | ENST00000376586 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-3CDS | ENST00000375329 | ENST00000595437 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-intron | ENST00000236850 | ENST00000376581 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-intron | ENST00000236850 | ENST00000593990 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-intron | ENST00000359492 | ENST00000376581 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-intron | ENST00000359492 | ENST00000593990 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-intron | ENST00000375320 | ENST00000376581 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-intron | ENST00000375320 | ENST00000593990 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-intron | ENST00000375323 | ENST00000376581 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-intron | ENST00000375323 | ENST00000593990 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-intron | ENST00000375329 | ENST00000376581 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
intron-intron | ENST00000375329 | ENST00000593990 | APOA1 | chr11 | 116706808 | - | FARP1 | chr13 | 99087897 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for APOA1-FARP1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for APOA1-FARP1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:116706808/:99087897) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
APOA1 | . |
FUNCTION: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for APOA1-FARP1 |
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Fusion Gene PPI Analysis for APOA1-FARP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for APOA1-FARP1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | APOA1 | P02647 | DB14548 | Zinc sulfate, unspecified form | Inducer|Ligand | Small molecule | Approved|Experimental |
Hgene | APOA1 | P02647 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
Hgene | APOA1 | P02647 | DB09130 | Copper | Small molecule | Approved|Investigational | |
Hgene | APOA1 | P02647 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
Hgene | APOA1 | P02647 | DB14533 | Zinc chloride | Inducer|Ligand | Small molecule | Approved|Investigational |
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Related Diseases for APOA1-FARP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | APOA1 | C0268389 | Amyloidosis, familial visceral | 8 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | APOA1 | C1704429 | Hypoalphalipoproteinemia, Familial | 3 | GENOMICS_ENGLAND;ORPHANET |
Hgene | APOA1 | C0024623 | Malignant neoplasm of stomach | 2 | CTD_human |
Hgene | APOA1 | C0038356 | Stomach Neoplasms | 2 | CTD_human |
Hgene | APOA1 | C0342898 | Apolipoprotein A-I deficiency | 2 | ORPHANET |
Hgene | APOA1 | C1708349 | Hereditary Diffuse Gastric Cancer | 2 | CTD_human |
Hgene | APOA1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | APOA1 | C0003129 | Anoxemia | 1 | CTD_human |
Hgene | APOA1 | C0003130 | Anoxia | 1 | CTD_human |
Hgene | APOA1 | C0004943 | Behcet Syndrome | 1 | CTD_human |
Hgene | APOA1 | C0010054 | Coronary Arteriosclerosis | 1 | CTD_human |
Hgene | APOA1 | C0011609 | Drug Eruptions | 1 | CTD_human |
Hgene | APOA1 | C0013604 | Edema | 1 | CTD_human |
Hgene | APOA1 | C0017665 | Membranous glomerulonephritis | 1 | CTD_human |
Hgene | APOA1 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Hgene | APOA1 | C0019693 | HIV Infections | 1 | CTD_human |
Hgene | APOA1 | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | APOA1 | C0021368 | Inflammation | 1 | CTD_human |
Hgene | APOA1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | APOA1 | C0038454 | Cerebrovascular accident | 1 | CTD_human |
Hgene | APOA1 | C0079221 | Determination of Death | 1 | CTD_human |
Hgene | APOA1 | C0086445 | Idiopathic Membranous Glomerulonephritis | 1 | CTD_human |
Hgene | APOA1 | C0151603 | Anasarca | 1 | CTD_human |
Hgene | APOA1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | APOA1 | C0154251 | Lipid Metabolism Disorders | 1 | CTD_human |
Hgene | APOA1 | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
Hgene | APOA1 | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
Hgene | APOA1 | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
Hgene | APOA1 | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
Hgene | APOA1 | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
Hgene | APOA1 | C0242184 | Hypoxia | 1 | CTD_human |
Hgene | APOA1 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
Hgene | APOA1 | C0242488 | Acute Lung Injury | 1 | CTD_human |
Hgene | APOA1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | APOA1 | C0376297 | Cardiac Death | 1 | CTD_human |
Hgene | APOA1 | C0406537 | Morbilliform Drug Reaction | 1 | CTD_human |
Hgene | APOA1 | C0700292 | Hypoxemia | 1 | CTD_human |
Hgene | APOA1 | C0751956 | Acute Cerebrovascular Accidents | 1 | CTD_human |
Hgene | APOA1 | C0853897 | Diabetic Cardiomyopathies | 1 | CTD_human |
Hgene | APOA1 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Hgene | APOA1 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Hgene | APOA1 | C1704378 | Heymann Nephritis | 1 | CTD_human |
Hgene | APOA1 | C1848533 | Ataxia with vitamin E deficiency | 1 | CTD_human |
Hgene | APOA1 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
Hgene | APOA1 | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | APOA1 | C2362324 | Pediatric Obesity | 1 | CTD_human |
Hgene | APOA1 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Hgene | APOA1 | C4087498 | Familial LCAT deficiency | 1 | GENOMICS_ENGLAND |
Hgene | APOA1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Hgene | APOA1 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
Hgene | APOA1 | C4317171 | Adolescent Obesity | 1 | CTD_human |
Hgene | APOA1 | C4505456 | HIV Coinfection | 1 | CTD_human |
Hgene | APOA1 | C4521075 | Childhood Overweight | 1 | CTD_human |
Hgene | APOA1 | C4553478 | Infantile Obesity | 1 | CTD_human |
Hgene | APOA1 | C4704955 | Infant Overweight | 1 | CTD_human |
Hgene | APOA1 | C4704956 | Adolescent Overweight | 1 | CTD_human |
Tgene | C0013146 | Drug abuse | 1 | CTD_human | |
Tgene | C0013170 | Drug habituation | 1 | CTD_human | |
Tgene | C0013222 | Drug Use Disorders | 1 | CTD_human | |
Tgene | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human | |
Tgene | C0038580 | Substance Dependence | 1 | CTD_human | |
Tgene | C0038586 | Substance Use Disorders | 1 | CTD_human | |
Tgene | C0236969 | Substance-Related Disorders | 1 | CTD_human | |
Tgene | C0740858 | Substance abuse problem | 1 | CTD_human | |
Tgene | C1510472 | Drug Dependence | 1 | CTD_human | |
Tgene | C4316881 | Prescription Drug Abuse | 1 | CTD_human |