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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD42-PICALM (FusionGDB2 ID:HG338699TG8301)

Fusion Gene Summary for ANKRD42-PICALM

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD42-PICALM
Fusion gene ID: hg338699tg8301
HgeneTgene
Gene symbol

ANKRD42

PICALM

Gene ID

338699

8301

Gene nameankyrin repeat domain 42phosphatidylinositol binding clathrin assembly protein
SynonymsPPP1R79|SARPCALM|CLTH|LAP
Cytomap('ANKRD42')('PICALM')

11q14.1

11q14.2

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 42protein phosphatase 1, regulatory subunit 79several ankyrin repeat proteinphosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein
Modification date2020031320200322
UniProtAcc

Q8N9B4

Q13492

Ensembl transtripts involved in fusion geneENST00000260047, ENST00000393389, 
ENST00000526731, ENST00000531895, 
ENST00000533342, ENST00000528722, 
ENST00000393392, ENST00000528190, 
Fusion gene scores* DoF score6 X 6 X 3=10835 X 26 X 12=10920
# samples 644
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(44/10920*10)=-4.63332552228256
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD42 [Title/Abstract] AND PICALM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD42(82909684)-PICALM(85670103), # samples:1
Anticipated loss of major functional domain due to fusion event.ANKRD42-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD42-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD42-PICALM seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ANKRD42-PICALM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePICALM

GO:0006897

endocytosis

22118466

TgenePICALM

GO:0006898

receptor-mediated endocytosis

10436022

TgenePICALM

GO:0032880

regulation of protein localization

10436022

TgenePICALM

GO:0045893

positive regulation of transcription, DNA-templated

11425879

TgenePICALM

GO:0048261

negative regulation of receptor-mediated endocytosis

10436022

TgenePICALM

GO:1905224

clathrin-coated pit assembly

16262731


check buttonFusion gene breakpoints across ANKRD42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PICALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-7422-01AANKRD42chr11

82909684

+PICALMchr11

85670103

-


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Fusion Gene ORF analysis for ANKRD42-PICALM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000260047ENST00000528411ANKRD42chr11

82909684

+PICALMchr11

85670103

-
5CDS-intronENST00000393389ENST00000528411ANKRD42chr11

82909684

+PICALMchr11

85670103

-
5CDS-intronENST00000526731ENST00000528411ANKRD42chr11

82909684

+PICALMchr11

85670103

-
5CDS-intronENST00000531895ENST00000528411ANKRD42chr11

82909684

+PICALMchr11

85670103

-
5CDS-intronENST00000533342ENST00000528411ANKRD42chr11

82909684

+PICALMchr11

85670103

-
5UTR-3CDSENST00000528722ENST00000356360ANKRD42chr11

82909684

+PICALMchr11

85670103

-
5UTR-3CDSENST00000528722ENST00000393346ANKRD42chr11

82909684

+PICALMchr11

85670103

-
5UTR-3CDSENST00000528722ENST00000526033ANKRD42chr11

82909684

+PICALMchr11

85670103

-
5UTR-3CDSENST00000528722ENST00000528398ANKRD42chr11

82909684

+PICALMchr11

85670103

-
5UTR-3CDSENST00000528722ENST00000532317ANKRD42chr11

82909684

+PICALMchr11

85670103

-
5UTR-intronENST00000528722ENST00000528411ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000260047ENST00000393346ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000260047ENST00000526033ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000260047ENST00000528398ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000393389ENST00000393346ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000393389ENST00000526033ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000393389ENST00000528398ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000526731ENST00000393346ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000526731ENST00000526033ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000526731ENST00000528398ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000531895ENST00000393346ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000531895ENST00000526033ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000531895ENST00000528398ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000533342ENST00000393346ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000533342ENST00000526033ANKRD42chr11

82909684

+PICALMchr11

85670103

-
Frame-shiftENST00000533342ENST00000528398ANKRD42chr11

82909684

+PICALMchr11

85670103

-
In-frameENST00000260047ENST00000356360ANKRD42chr11

82909684

+PICALMchr11

85670103

-
In-frameENST00000260047ENST00000532317ANKRD42chr11

82909684

+PICALMchr11

85670103

-
In-frameENST00000393389ENST00000356360ANKRD42chr11

82909684

+PICALMchr11

85670103

-
In-frameENST00000393389ENST00000532317ANKRD42chr11

82909684

+PICALMchr11

85670103

-
In-frameENST00000526731ENST00000356360ANKRD42chr11

82909684

+PICALMchr11

85670103

-
In-frameENST00000526731ENST00000532317ANKRD42chr11

82909684

+PICALMchr11

85670103

-
In-frameENST00000531895ENST00000356360ANKRD42chr11

82909684

+PICALMchr11

85670103

-
In-frameENST00000531895ENST00000532317ANKRD42chr11

82909684

+PICALMchr11

85670103

-
In-frameENST00000533342ENST00000356360ANKRD42chr11

82909684

+PICALMchr11

85670103

-
In-frameENST00000533342ENST00000532317ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-3CDSENST00000393392ENST00000356360ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-3CDSENST00000393392ENST00000393346ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-3CDSENST00000393392ENST00000526033ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-3CDSENST00000393392ENST00000528398ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-3CDSENST00000393392ENST00000532317ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-3CDSENST00000528190ENST00000356360ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-3CDSENST00000528190ENST00000393346ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-3CDSENST00000528190ENST00000526033ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-3CDSENST00000528190ENST00000528398ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-3CDSENST00000528190ENST00000532317ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-intronENST00000393392ENST00000528411ANKRD42chr11

82909684

+PICALMchr11

85670103

-
intron-intronENST00000528190ENST00000528411ANKRD42chr11

82909684

+PICALMchr11

85670103

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393389ANKRD42chr1182909684+ENST00000532317PICALMchr1185670103-25311154321168378
ENST00000393389ANKRD42chr1182909684+ENST00000356360PICALMchr1185670103-12281154321168378
ENST00000260047ANKRD42chr1182909684+ENST00000532317PICALMchr1185670103-239410171501031293
ENST00000260047ANKRD42chr1182909684+ENST00000356360PICALMchr1185670103-109110171501031293
ENST00000526731ANKRD42chr1182909684+ENST00000532317PICALMchr1185670103-2021644576205123
ENST00000526731ANKRD42chr1182909684+ENST00000356360PICALMchr1185670103-718644576205123
ENST00000531895ANKRD42chr1182909684+ENST00000532317PICALMchr1185670103-187249542756123
ENST00000531895ANKRD42chr1182909684+ENST00000356360PICALMchr1185670103-56949542756123
ENST00000533342ANKRD42chr1182909684+ENST00000532317PICALMchr1185670103-16252482626278
ENST00000533342ANKRD42chr1182909684+ENST00000356360PICALMchr1185670103-3222482626278

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393389ENST00000532317ANKRD42chr1182909684+PICALMchr1185670103-0.75820440.24179566
ENST00000393389ENST00000356360ANKRD42chr1182909684+PICALMchr1185670103-0.434968650.56503135
ENST00000260047ENST00000532317ANKRD42chr1182909684+PICALMchr1185670103-0.689722660.31027734
ENST00000260047ENST00000356360ANKRD42chr1182909684+PICALMchr1185670103-0.383736760.6162633
ENST00000526731ENST00000532317ANKRD42chr1182909684+PICALMchr1185670103-0.71907090.28092906
ENST00000526731ENST00000356360ANKRD42chr1182909684+PICALMchr1185670103-0.436163930.5638361
ENST00000531895ENST00000532317ANKRD42chr1182909684+PICALMchr1185670103-0.312337550.6876624
ENST00000531895ENST00000356360ANKRD42chr1182909684+PICALMchr1185670103-0.18290780.8170922
ENST00000533342ENST00000532317ANKRD42chr1182909684+PICALMchr1185670103-0.306487350.6935127
ENST00000533342ENST00000356360ANKRD42chr1182909684+PICALMchr1185670103-0.151151940.848848

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Fusion Genomic Features for ANKRD42-PICALM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANKRD42-PICALM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:82909684/chr11:85670103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD42

Q8N9B4

PICALM

Q13492

FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393389+2625_6074199.0RepeatNote=ANK 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393389+26130_15974199.0RepeatNote=ANK 4
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393389+26163_19274199.0RepeatNote=ANK 5
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393389+26200_23274199.0RepeatNote=ANK 6
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393389+26235_26574199.0RepeatNote=ANK 7
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393389+26269_29874199.0RepeatNote=ANK 8
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393389+26302_33274199.0RepeatNote=ANK 9
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393389+2664_9374199.0RepeatNote=ANK 2
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393389+2697_12674199.0RepeatNote=ANK 3
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393392+110130_1590390.0RepeatNote=ANK 4
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393392+110163_1920390.0RepeatNote=ANK 5
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393392+110200_2320390.0RepeatNote=ANK 6
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393392+110235_2650390.0RepeatNote=ANK 7
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393392+11025_600390.0RepeatNote=ANK 1
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393392+110269_2980390.0RepeatNote=ANK 8
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393392+110302_3320390.0RepeatNote=ANK 9
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393392+11064_930390.0RepeatNote=ANK 2
HgeneANKRD42chr11:82909684chr11:85670103ENST00000393392+11097_1260390.0RepeatNote=ANK 3
TgenePICALMchr11:82909684chr11:85670103ENST00000356360171914_145628633.0DomainENTH
TgenePICALMchr11:82909684chr11:85670103ENST00000393346182014_145648653.0DomainENTH
TgenePICALMchr11:82909684chr11:85670103ENST00000526033182014_145641646.0DomainENTH
TgenePICALMchr11:82909684chr11:85670103ENST00000528398171914_145547552.0DomainENTH
TgenePICALMchr11:82909684chr11:85670103ENST00000532317182014_145606611.0DomainENTH


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Fusion Gene Sequence for ANKRD42-PICALM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4731_4731_1_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000260047_PICALM_chr11_85670103_ENST00000356360_length(transcript)=1091nt_BP=1017nt
TGGAGGATAAACGGTCTACACGGCCATTCCGGCGCCGAGTCTAGGGAAAGAGTTAGCGACGACGGGGAAAGAAAATGTGAAGAGAGCGAC
CGCCGCTCCAGGGTCGCTGCAGGAAGCCTAAGTGCAGACGCCGGCTTCTCCCGCAGTGACTTGAGAAGGGTCAGTGAAAACCTCGGCCAC
TGCCGCAGCGTCTCTAGGGAGAGAGTTAGGGGAGATAGTGGCCACAGTCACAGCTGCTCTTGGGAGAGAGTTAGGGGAGACAGCACCTTC
TGCAGCAGCGACGTGAATTTTAGTGAAGTTGGAGGCCACCAAACTACCGACTCCAGGGGAACAGCCAGAGAAGACCGAGGCCTCCGCCTC
AGTGGTCCTTGGGAGGGAGTCAGTGACATTCGGGACCCGCGAACTAGTGACTTCGGGGATAGAGTCAGTGACGATCGCAGTCGCCGCTTC
AGTGGCTCCTGGGAGGGAGGGAGTGTCGAAGGCGGCCACAGCGTTGGTAGTTCTTGGGAGGAAGTAAGTGGAGACCGCGGCTACGCAGCC
AGCGACTCCTCTGGTGTGAGCGGCAGTGAAGACGCCAGCTACCGCTTCAGTGGCTTTTGGGAGAGAGAAAGTGAAGACGAAGGTTTCCGC
TGCAGCTTCTGGGAGAGAGCAAGAGAGGACCTTGGGCCCCGTCCTAGTGACGACGGAGAAGAGGGCCGCTGCCGCTGCAGTGGCTCGTGG
GTGAGAGCAAGTGAAGACCGCCGCAGCATCAGGGGCCTGGACTCAACTCCTCCCCAGAGTCGGAGGTGTTGCGCCATGCCCGGGGTGGCC
AATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCAGGAAGAAGGTGCATTTTGGCAGCATACATGATGCAGTACGA
GCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCATTAATGAACTTGATGTTCTCCATAAGTTTACCCCTTTACAT
TGGGCAGCACATTCTGGAAGTTTGGAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCA

>4731_4731_1_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000260047_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=293AA_BP=
MRRVSENLGHCRSVSRERVRGDSGHSHSCSWERVRGDSTFCSSDVNFSEVGGHQTTDSRGTAREDRGLRLSGPWEGVSDIRDPRTSDFGD
RVSDDRSRRFSGSWEGGSVEGGHSVGSSWEEVSGDRGYAASDSSGVSGSEDASYRFSGFWERESEDEGFRCSFWERAREDLGPRPSDDGE
EGRCRCSGSWVRASEDRRSIRGLDSTPPQSRRCCAMPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINEL

--------------------------------------------------------------
>4731_4731_2_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000260047_PICALM_chr11_85670103_ENST00000532317_length(transcript)=2394nt_BP=1017nt
TGGAGGATAAACGGTCTACACGGCCATTCCGGCGCCGAGTCTAGGGAAAGAGTTAGCGACGACGGGGAAAGAAAATGTGAAGAGAGCGAC
CGCCGCTCCAGGGTCGCTGCAGGAAGCCTAAGTGCAGACGCCGGCTTCTCCCGCAGTGACTTGAGAAGGGTCAGTGAAAACCTCGGCCAC
TGCCGCAGCGTCTCTAGGGAGAGAGTTAGGGGAGATAGTGGCCACAGTCACAGCTGCTCTTGGGAGAGAGTTAGGGGAGACAGCACCTTC
TGCAGCAGCGACGTGAATTTTAGTGAAGTTGGAGGCCACCAAACTACCGACTCCAGGGGAACAGCCAGAGAAGACCGAGGCCTCCGCCTC
AGTGGTCCTTGGGAGGGAGTCAGTGACATTCGGGACCCGCGAACTAGTGACTTCGGGGATAGAGTCAGTGACGATCGCAGTCGCCGCTTC
AGTGGCTCCTGGGAGGGAGGGAGTGTCGAAGGCGGCCACAGCGTTGGTAGTTCTTGGGAGGAAGTAAGTGGAGACCGCGGCTACGCAGCC
AGCGACTCCTCTGGTGTGAGCGGCAGTGAAGACGCCAGCTACCGCTTCAGTGGCTTTTGGGAGAGAGAAAGTGAAGACGAAGGTTTCCGC
TGCAGCTTCTGGGAGAGAGCAAGAGAGGACCTTGGGCCCCGTCCTAGTGACGACGGAGAAGAGGGCCGCTGCCGCTGCAGTGGCTCGTGG
GTGAGAGCAAGTGAAGACCGCCGCAGCATCAGGGGCCTGGACTCAACTCCTCCCCAGAGTCGGAGGTGTTGCGCCATGCCCGGGGTGGCC
AATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCAGGAAGAAGGTGCATTTTGGCAGCATACATGATGCAGTACGA
GCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCATTAATGAACTTGATGTTCTCCATAAGTTTACCCCTTTACAT
TGGGCAGCACATTCTGGAAGTTTGGAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCA
GCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAG
TGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAA
GATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGG
AAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAA
ATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAA
AAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATTTATGATTATCAATTTTACATAACATTAATATTGTATCAG
ACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTATCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTG
ACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTAT
AAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCA
GCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGT
GAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTG
AACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGT
TTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGA
CAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAA

>4731_4731_2_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000260047_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=293AA_BP=
MRRVSENLGHCRSVSRERVRGDSGHSHSCSWERVRGDSTFCSSDVNFSEVGGHQTTDSRGTAREDRGLRLSGPWEGVSDIRDPRTSDFGD
RVSDDRSRRFSGSWEGGSVEGGHSVGSSWEEVSGDRGYAASDSSGVSGSEDASYRFSGFWERESEDEGFRCSFWERAREDLGPRPSDDGE
EGRCRCSGSWVRASEDRRSIRGLDSTPPQSRRCCAMPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINEL

--------------------------------------------------------------
>4731_4731_3_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000393389_PICALM_chr11_85670103_ENST00000356360_length(transcript)=1228nt_BP=1154nt
GCCTCTCCAGCCAAGTGGCTGGAGTCGGGAGGCTGGAAAGAGACTCCGAGAAAGTACCAGCGGAAGGCGGCCGCCGCTACGGCGATTCGC
AGGGAGTAGCAGACGAAGACGGTGGCCGCCGCACTAGCCACCACGTGTGGAGGATAAACGGTCTACACGGCCATTCCGGCGCCGAGTCTA
GGGAAAGAGTTAGCGACGACGGGGAAAGAAAATGTGAAGAGAGCGACCGCCGCTCCAGGGTCGCTGCAGGAAGCCTAAGTGCAGACGCCG
GCTTCTCCCGCAGTGACTTGAGAAGGGTCAGTGAAAACCTCGGCCACTGCCGCAGCGTCTCTAGGGAGAGAGTTAGGGGAGATAGTGGCC
ACAGTCACAGCTGCTCTTGGGAGAGAGTTAGGGGAGACAGCACCTTCTGCAGCAGCGACGTGAATTTTAGTGAAGTTGGAGGCCACCAAA
CTACCGACTCCAGGGGAACAGCCAGAGAAGACCGAGGCCTCCGCCTCAGTGGTCCTTGGGAGGGAGTCAGTGACATTCGGGACCCGCGAA
CTAGTGACTTCGGGGATAGAGTCAGTGACGATCGCAGTCGCCGCTTCAGTGGCTCCTGGGAGGGAGGGAGTGTCGAAGGCGGCCACAGCG
TTGGTAGTTCTTGGGAGGAAGTAAGTGGAGACCGCGGCTACGCAGCCAGCGACTCCTCTGGTGTGAGCGGCAGTGAAGACGCCAGCTACC
GCTTCAGTGGCTTTTGGGAGAGAGAAAGTGAAGACGAAGGTTTCCGCTGCAGCTTCTGGGAGAGAGCAAGAGAGGACCTTGGGCCCCGTC
CTAGTGACGACGGAGAAGAGGGCCGCTGCCGCTGCAGTGGCTCGTGGGTGAGAGCAAGTGAAGACCGCCGCAGCATCAGGGGCCTGGACT
CAACTCCTCCCCAGAGTCGGAGGTGTTGCGCCATGCCCGGGGTGGCCAATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCT
GTTCCAGGAAGAAGGTGCATTTTGGCAGCATACATGATGCAGTACGAGCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAG
CCAGCATTAATGAACTTGATGTTCTCCATAAGTTTACCCCTTTACATTGGGCAGCACATTCTGGAAGTTTGGAGATACAGTTTATGTAAC

>4731_4731_3_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000393389_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=378AA_BP=
MERDSEKVPAEGGRRYGDSQGVADEDGGRRTSHHVWRINGLHGHSGAESRERVSDDGERKCEESDRRSRVAAGSLSADAGFSRSDLRRVS
ENLGHCRSVSRERVRGDSGHSHSCSWERVRGDSTFCSSDVNFSEVGGHQTTDSRGTAREDRGLRLSGPWEGVSDIRDPRTSDFGDRVSDD
RSRRFSGSWEGGSVEGGHSVGSSWEEVSGDRGYAASDSSGVSGSEDASYRFSGFWERESEDEGFRCSFWERAREDLGPRPSDDGEEGRCR
CSGSWVRASEDRRSIRGLDSTPPQSRRCCAMPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHK

--------------------------------------------------------------
>4731_4731_4_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000393389_PICALM_chr11_85670103_ENST00000532317_length(transcript)=2531nt_BP=1154nt
GCCTCTCCAGCCAAGTGGCTGGAGTCGGGAGGCTGGAAAGAGACTCCGAGAAAGTACCAGCGGAAGGCGGCCGCCGCTACGGCGATTCGC
AGGGAGTAGCAGACGAAGACGGTGGCCGCCGCACTAGCCACCACGTGTGGAGGATAAACGGTCTACACGGCCATTCCGGCGCCGAGTCTA
GGGAAAGAGTTAGCGACGACGGGGAAAGAAAATGTGAAGAGAGCGACCGCCGCTCCAGGGTCGCTGCAGGAAGCCTAAGTGCAGACGCCG
GCTTCTCCCGCAGTGACTTGAGAAGGGTCAGTGAAAACCTCGGCCACTGCCGCAGCGTCTCTAGGGAGAGAGTTAGGGGAGATAGTGGCC
ACAGTCACAGCTGCTCTTGGGAGAGAGTTAGGGGAGACAGCACCTTCTGCAGCAGCGACGTGAATTTTAGTGAAGTTGGAGGCCACCAAA
CTACCGACTCCAGGGGAACAGCCAGAGAAGACCGAGGCCTCCGCCTCAGTGGTCCTTGGGAGGGAGTCAGTGACATTCGGGACCCGCGAA
CTAGTGACTTCGGGGATAGAGTCAGTGACGATCGCAGTCGCCGCTTCAGTGGCTCCTGGGAGGGAGGGAGTGTCGAAGGCGGCCACAGCG
TTGGTAGTTCTTGGGAGGAAGTAAGTGGAGACCGCGGCTACGCAGCCAGCGACTCCTCTGGTGTGAGCGGCAGTGAAGACGCCAGCTACC
GCTTCAGTGGCTTTTGGGAGAGAGAAAGTGAAGACGAAGGTTTCCGCTGCAGCTTCTGGGAGAGAGCAAGAGAGGACCTTGGGCCCCGTC
CTAGTGACGACGGAGAAGAGGGCCGCTGCCGCTGCAGTGGCTCGTGGGTGAGAGCAAGTGAAGACCGCCGCAGCATCAGGGGCCTGGACT
CAACTCCTCCCCAGAGTCGGAGGTGTTGCGCCATGCCCGGGGTGGCCAATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCT
GTTCCAGGAAGAAGGTGCATTTTGGCAGCATACATGATGCAGTACGAGCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAG
CCAGCATTAATGAACTTGATGTTCTCCATAAGTTTACCCCTTTACATTGGGCAGCACATTCTGGAAGTTTGGAGATACAGTTTATGTAAC
TTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTA
AATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACG
TATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCC
TGTTAATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGA
ACTGTGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCC
TCACAAATACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTG
TATTTATTTATGATTATCAATTTTACATAACATTAATATTGTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGA
TTTTTATCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTG
AATCTCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTG
CCAGGGAACAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGC
ATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAA
ACTCTAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTT
TAAATAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTG
TGTAAATACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCAT
TCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAAATGTATGTTAGCAAAATGGGTGGATTTTCAAATAAAATGCAG

>4731_4731_4_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000393389_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=378AA_BP=
MERDSEKVPAEGGRRYGDSQGVADEDGGRRTSHHVWRINGLHGHSGAESRERVSDDGERKCEESDRRSRVAAGSLSADAGFSRSDLRRVS
ENLGHCRSVSRERVRGDSGHSHSCSWERVRGDSTFCSSDVNFSEVGGHQTTDSRGTAREDRGLRLSGPWEGVSDIRDPRTSDFGDRVSDD
RSRRFSGSWEGGSVEGGHSVGSSWEEVSGDRGYAASDSSGVSGSEDASYRFSGFWERESEDEGFRCSFWERAREDLGPRPSDDGEEGRCR
CSGSWVRASEDRRSIRGLDSTPPQSRRCCAMPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHK

--------------------------------------------------------------
>4731_4731_5_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000526731_PICALM_chr11_85670103_ENST00000356360_length(transcript)=718nt_BP=644nt
AGGGAGTCAGTGACATTCGGGACCCGCGAACTAGTGACTTCGGGGATAGAGTCAGTGACGATCGCAGTCGCCGCTTCAGTGGCTCCTGGG
AGGGAGGGAGTGTCGAAGGCGGCCACAGCGTTGGTAGTTCTTGGGAGGAAGTAAGTGGAGACCGCGGCTACGCAGCCAGCGACTCCTCTG
GTGTGAGCGGCAGTGAAGACGCCAGCTACCGCTTCAGTGGCTTTTGGGAGAGAGAAAGTGAAGACGAAGGTTTCCGCTGCAGCTTCTGGG
AGAGAGCAAGAGAGGACCTTGGGCCCCGTCCTAGTGACGACGGAGAAGAGGGCCGCTGCCGCTGCAGTGGCTCGTGGGTGAGAGCAAGTG
AAGACCGCCGCAGCATCAGGGGCCTGGACTCAACTCCTCCCCAGAGTCGGAGGTGTTGCGCCATGCCCGGGGTGGCCAATTCAGGCCCCT
CCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCAGGAAGAAGGTGCATTTTGGCAGCATACATGATGCAGTACGAGCTGGAGATGTAA
AGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCATTAATGAACTTGATGTTCTCCATAAGTTTACCCCTTTACATTGGGCAGCACATT

>4731_4731_5_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000526731_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=123AA_BP=
MLAPRTTISESCFTSPARTASCMLPKCTFFLEQGFAVSLEEVEGPELATPGMAQHLRLWGGVESRPLMLRRSSLALTHEPLQRQRPSSPS

--------------------------------------------------------------
>4731_4731_6_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000526731_PICALM_chr11_85670103_ENST00000532317_length(transcript)=2021nt_BP=644nt
AGGGAGTCAGTGACATTCGGGACCCGCGAACTAGTGACTTCGGGGATAGAGTCAGTGACGATCGCAGTCGCCGCTTCAGTGGCTCCTGGG
AGGGAGGGAGTGTCGAAGGCGGCCACAGCGTTGGTAGTTCTTGGGAGGAAGTAAGTGGAGACCGCGGCTACGCAGCCAGCGACTCCTCTG
GTGTGAGCGGCAGTGAAGACGCCAGCTACCGCTTCAGTGGCTTTTGGGAGAGAGAAAGTGAAGACGAAGGTTTCCGCTGCAGCTTCTGGG
AGAGAGCAAGAGAGGACCTTGGGCCCCGTCCTAGTGACGACGGAGAAGAGGGCCGCTGCCGCTGCAGTGGCTCGTGGGTGAGAGCAAGTG
AAGACCGCCGCAGCATCAGGGGCCTGGACTCAACTCCTCCCCAGAGTCGGAGGTGTTGCGCCATGCCCGGGGTGGCCAATTCAGGCCCCT
CCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCAGGAAGAAGGTGCATTTTGGCAGCATACATGATGCAGTACGAGCTGGAGATGTAA
AGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCATTAATGAACTTGATGTTCTCCATAAGTTTACCCCTTTACATTGGGCAGCACATT
CTGGAAGTTTGGAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTTAC
TTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGTGAAGGCCCATGA
AGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAGATCTGTCTTTTT
GGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGAAAGTGTGAAATT
TGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAAATTAAAATTCCTA
ATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAAAAAAATTATATTC
AGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATTTATGATTATCAATTTTACATAACATTAATATTGTATCAGACCTCCTTATGAA
AATGAGTATGGATGTGCACAGTATGTTTGATTTTTATCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGACATACAGAGCAC
TAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTATAAATGCATTAATC
CTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCAGCATTAGTGCATT
GGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGTGAGGAATTGCTTT
CACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTG
GCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAG
AATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGACAGTTCATTGTAG
GAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAAATGTATGTTAGC

>4731_4731_6_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000526731_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=123AA_BP=
MLAPRTTISESCFTSPARTASCMLPKCTFFLEQGFAVSLEEVEGPELATPGMAQHLRLWGGVESRPLMLRRSSLALTHEPLQRQRPSSPS

--------------------------------------------------------------
>4731_4731_7_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000531895_PICALM_chr11_85670103_ENST00000356360_length(transcript)=569nt_BP=495nt
GACCGCGGCTACGCAGCCAGCGACTCCTCTGGTGTGAGCGGCAGTGAAGACGCCAGCTACCGCTTCAGTGGCTTTTGGGAGAGAGAAAGT
GAAGACGAAGGTTTCCGCTGCAGCTTCTGGGAGAGAGCAAGAGAGGACCTTGGGCCCCGTCCTAGTGACGACGGAGAAGAGGGCCGCTGC
CGCTGCAGTGGCTCGTGGGTGAGAGCAAGTGAAGACCGCCGCAGCATCAGGGGCCTGGACTCAACTCCTCCCCAGAGTCGGAGGTGTTGC
GCCATGCCCGGGGTGGCCAATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCAGGAAGAAGGTGCATTTTGGCAGC
ATACATGATGCAGTACGAGCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCATTAATGAACTTGATGTTCTCCAT
AAGTTTACCCCTTTACATTGGGCAGCACATTCTGGAAGTTTGGAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAA

>4731_4731_7_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000531895_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=123AA_BP=
MLAPRTTISESCFTSPARTASCMLPKCTFFLEQGFAVSLEEVEGPELATPGMAQHLRLWGGVESRPLMLRRSSLALTHEPLQRQRPSSPS

--------------------------------------------------------------
>4731_4731_8_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000531895_PICALM_chr11_85670103_ENST00000532317_length(transcript)=1872nt_BP=495nt
GACCGCGGCTACGCAGCCAGCGACTCCTCTGGTGTGAGCGGCAGTGAAGACGCCAGCTACCGCTTCAGTGGCTTTTGGGAGAGAGAAAGT
GAAGACGAAGGTTTCCGCTGCAGCTTCTGGGAGAGAGCAAGAGAGGACCTTGGGCCCCGTCCTAGTGACGACGGAGAAGAGGGCCGCTGC
CGCTGCAGTGGCTCGTGGGTGAGAGCAAGTGAAGACCGCCGCAGCATCAGGGGCCTGGACTCAACTCCTCCCCAGAGTCGGAGGTGTTGC
GCCATGCCCGGGGTGGCCAATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCAGGAAGAAGGTGCATTTTGGCAGC
ATACATGATGCAGTACGAGCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCATTAATGAACTTGATGTTCTCCAT
AAGTTTACCCCTTTACATTGGGCAGCACATTCTGGAAGTTTGGAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAA
AAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGA
ATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATT
GCTATGATTTAAGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATACCCATAATCAGTAACCTATCA
AGAAAAGCCCTTATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACAGGA
CTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATT
AACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATTTATGATTATCAATTTTACATA
ACATTAATATTGTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTATCCACAAGAATGAATCTGATTCA
GAATGCTTTTCTCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTGTGG
GATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAG
CACTACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATTATTTTCCATTTGACATTAGGG
CCTTTCCAAAATGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAGGGA
AGGGGGGCAAAGTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCTTTAAAGT
TAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGA
GAGGGGCCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTCTAT

>4731_4731_8_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000531895_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=123AA_BP=
MLAPRTTISESCFTSPARTASCMLPKCTFFLEQGFAVSLEEVEGPELATPGMAQHLRLWGGVESRPLMLRRSSLALTHEPLQRQRPSSPS

--------------------------------------------------------------
>4731_4731_9_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000533342_PICALM_chr11_85670103_ENST00000356360_length(transcript)=322nt_BP=248nt
CTCCCCAGAGTCGGAGGTGTTGCGCCATGCCCGGGGTGGCCAATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCA
GGAAGAAGGTGCATTTTGGCAGCATACATGATGCAGTACGAGCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCA
TTAATGAACTTGATGTTCTCCATAAGTTTACCCCTTTACATTGGGCAGCACATTCTGGAAGTTTGGAGATACAGTTTATGTAACTTGATG

>4731_4731_9_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000533342_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=78AA_BP=

--------------------------------------------------------------
>4731_4731_10_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000533342_PICALM_chr11_85670103_ENST00000532317_length(transcript)=1625nt_BP=248nt
CTCCCCAGAGTCGGAGGTGTTGCGCCATGCCCGGGGTGGCCAATTCAGGCCCCTCCACTTCCTCTAGGGAGACTGCAAACCCCTGTTCCA
GGAAGAAGGTGCATTTTGGCAGCATACATGATGCAGTACGAGCTGGAGATGTAAAGCAGCTTTCAGAAATAGTGGTACGTGGAGCCAGCA
TTAATGAACTTGATGTTCTCCATAAGTTTACCCCTTTACATTGGGCAGCACATTCTGGAAGTTTGGAGATACAGTTTATGTAACTTGATG
GAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTC
TTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAA
TACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAA
TACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTG
TCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAA
ATACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTA
TTTATGATTATCAATTTTACATAACATTAATATTGTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTA
TCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTC
TTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGG
AACAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCA
TTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTA
GAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATA
AGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAA
TACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGT
TGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAAATGTATGTTAGCAAAATGGGTGGATTTTCAAATAAAATGCAGCTTCCA

>4731_4731_10_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000533342_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=78AA_BP=

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKRD42-PICALM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePICALMchr11:82909684chr11:85670103ENST000003563601719221_294628.0633.0PIMREG
TgenePICALMchr11:82909684chr11:85670103ENST000003933461820221_294648.0653.0PIMREG
TgenePICALMchr11:82909684chr11:85670103ENST000005260331820221_294641.0646.0PIMREG
TgenePICALMchr11:82909684chr11:85670103ENST000005283981719221_294547.0552.0PIMREG
TgenePICALMchr11:82909684chr11:85670103ENST000005323171820221_294606.0611.0PIMREG


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD42-PICALM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD42-PICALM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0002395Alzheimer's Disease2CTD_human
TgeneC0011265Presenile dementia2CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)2CTD_human
TgeneC0494463Alzheimer Disease, Late Onset2CTD_human
TgeneC0546126Acute Confusional Senile Dementia2CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset2CTD_human
TgeneC0750901Alzheimer Disease, Early Onset2CTD_human
TgeneC0234985Mental deterioration1CTD_human
TgeneC0338656Impaired cognition1CTD_human
TgeneC1270972Mild cognitive disorder1CTD_human