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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:C2orf70-CNOT10 (FusionGDB2 ID:HG339778TG25904) |
Fusion Gene Summary for C2orf70-CNOT10 |
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Fusion gene information | Fusion gene name: C2orf70-CNOT10 | Fusion gene ID: hg339778tg25904 | Hgene | Tgene | Gene symbol | C2orf70 | CNOT10 | Gene ID | 339778 | 25904 |
Gene name | family with sequence similarity 166 member C | CCR4-NOT transcription complex subunit 10 | |
Synonyms | C2orf70 | - | |
Cytomap | ('C2orf70')('CNOT10') 2p23.3 | 3p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM166CUPF0573 protein C2orf70 | CCR4-NOT transcription complex subunit 10 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q9H9A5 | |
Ensembl transtripts involved in fusion gene | ENST00000329615, ENST00000409392, | ||
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 7 X 6=336 |
# samples | 1 | 8 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C2orf70 [Title/Abstract] AND CNOT10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | C2orf70(26785554)-CNOT10(32800949), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | 13N | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
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Fusion Gene ORF analysis for C2orf70-CNOT10 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000329615 | ENST00000463697 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
5UTR-3CDS | ENST00000409392 | ENST00000328834 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
5UTR-3CDS | ENST00000409392 | ENST00000331889 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
5UTR-3CDS | ENST00000409392 | ENST00000454516 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
5UTR-3CDS | ENST00000409392 | ENST00000538368 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
5UTR-intron | ENST00000409392 | ENST00000463697 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
In-frame | ENST00000329615 | ENST00000328834 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
In-frame | ENST00000329615 | ENST00000331889 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
In-frame | ENST00000329615 | ENST00000454516 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
In-frame | ENST00000329615 | ENST00000538368 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000329615 | C2orf70 | chr2 | 26785554 | + | ENST00000331889 | CNOT10 | chr3 | 32800949 | + | 848 | 105 | 31 | 744 | 237 |
ENST00000329615 | C2orf70 | chr2 | 26785554 | + | ENST00000328834 | CNOT10 | chr3 | 32800949 | + | 1009 | 105 | 31 | 744 | 237 |
ENST00000329615 | C2orf70 | chr2 | 26785554 | + | ENST00000538368 | CNOT10 | chr3 | 32800949 | + | 798 | 105 | 31 | 354 | 107 |
ENST00000329615 | C2orf70 | chr2 | 26785554 | + | ENST00000454516 | CNOT10 | chr3 | 32800949 | + | 846 | 105 | 31 | 744 | 237 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000329615 | ENST00000331889 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + | 0.003649677 | 0.9963503 |
ENST00000329615 | ENST00000328834 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + | 0.002365881 | 0.99763405 |
ENST00000329615 | ENST00000538368 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + | 0.057133194 | 0.94286686 |
ENST00000329615 | ENST00000454516 | C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + | 0.003802507 | 0.9961976 |
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Fusion Genomic Features for C2orf70-CNOT10 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + | 1.71E-06 | 0.99999833 |
C2orf70 | chr2 | 26785554 | + | CNOT10 | chr3 | 32800949 | + | 1.71E-06 | 0.99999833 |
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Fusion Protein Features for C2orf70-CNOT10 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:26785554/chr3:32800949) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | CNOT10 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. {ECO:0000269|PubMed:23221646}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | CNOT10 | chr2:26785554 | chr3:32800949 | ENST00000328834 | 12 | 19 | 74_107 | 531 | 745.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | CNOT10 | chr2:26785554 | chr3:32800949 | ENST00000331889 | 11 | 18 | 74_107 | 504 | 718.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | CNOT10 | chr2:26785554 | chr3:32800949 | ENST00000454516 | 12 | 19 | 74_107 | 591 | 805.0 | Coiled coil | Ontology_term=ECO:0000255 |
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Fusion Gene Sequence for C2orf70-CNOT10 |
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>11664_11664_1_C2orf70-CNOT10_C2orf70_chr2_26785554_ENST00000329615_CNOT10_chr3_32800949_ENST00000328834_length(transcript)=1009nt_BP=105nt GCGCCAGGCTCGCTGTACTCGCGCACCCACCATGGCCTCCCGCAGCGCGGGCACCCTACTGACCGAGTTCAATGCCGCCTACGTGCCCCC TGGACTCATGCCCGGGTGCTCCATACTTGCTTGCAGTGCCTACGTGGCTCTGGCTTTGGGTGATAACCTCATGGCTTTGAATCATGCAGA TAAACTTCTTCAGCAGCCCAAGCTGTCAGGATCTCTTAAGTTTTTGGGACATTTATATGCTGCAGAAGCCCTCATCTCTCTCGACAGAAT ATCTGATGCCATTACTCACTTGAACCCGGAGAATGTCACTGATGTCTCCTTAGGGATCTCTTCAAATGAGCAGGACCAAGGATCAGACAA AGGTGAAAATGAAGCAATGGAATCCTCTGGTAAGCGGGCCCCTCAGTGCTACCCCAGTTCCGTCAACTCTGCCAGGACTGTGATGCTGTT CAACCTTGGCAGCGCTTACTGCCTGAGGAGCGAATATGACAAAGCCCGAAAGTGTCTCCACCAGGCGGCTTCAATGATCCATCCTAAAGA GGTGCCCCCTGAGGCCATCTTGCTGGCAGTCTACCTTGAACTGCAGAATGGTAATACTCAGCTGGCCTTACAGATCATCAAAAGGAATCA GCTGCTCCCTGCAGTGAAAACACACTCTGAAGTGAGAAAGAAGCCAGTGTTTCAGCCTGTCCACCCGATCCAGCCCATCCAAATGCCGGC TTTCACCACTGTGCAGAGAAAGTGATACTTCACTTTTGGAAAACTGTTACCTGAGACCCAGGGGAGAATTTACTGGCCATTTTAGTTGTA TCACAGCAGAATGAATAAAAGATGGTGAAGGCTGTTAATTTTGAGTCAATTCTACCCCTGACATTTGGCCAAAAGCTTACTTAAAATTAA GGATTTACTAAGTCATCATCAGCTGTTTTTCTTAATTTCAGCCAGACTATTAATTTTGAGCCATTATGTAATATATGCCATAGGCAATTA AAACATAATTTTATCAGAA >11664_11664_1_C2orf70-CNOT10_C2orf70_chr2_26785554_ENST00000329615_CNOT10_chr3_32800949_ENST00000328834_length(amino acids)=237AA_BP=25 MASRSAGTLLTEFNAAYVPPGLMPGCSILACSAYVALALGDNLMALNHADKLLQQPKLSGSLKFLGHLYAAEALISLDRISDAITHLNPE NVTDVSLGISSNEQDQGSDKGENEAMESSGKRAPQCYPSSVNSARTVMLFNLGSAYCLRSEYDKARKCLHQAASMIHPKEVPPEAILLAV YLELQNGNTQLALQIIKRNQLLPAVKTHSEVRKKPVFQPVHPIQPIQMPAFTTVQRK -------------------------------------------------------------- >11664_11664_2_C2orf70-CNOT10_C2orf70_chr2_26785554_ENST00000329615_CNOT10_chr3_32800949_ENST00000331889_length(transcript)=848nt_BP=105nt GCGCCAGGCTCGCTGTACTCGCGCACCCACCATGGCCTCCCGCAGCGCGGGCACCCTACTGACCGAGTTCAATGCCGCCTACGTGCCCCC TGGACTCATGCCCGGGTGCTCCATACTTGCTTGCAGTGCCTACGTGGCTCTGGCTTTGGGTGATAACCTCATGGCTTTGAATCATGCAGA TAAACTTCTTCAGCAGCCCAAGCTGTCAGGATCTCTTAAGTTTTTGGGACATTTATATGCTGCAGAAGCCCTCATCTCTCTCGACAGAAT ATCTGATGCCATTACTCACTTGAACCCGGAGAATGTCACTGATGTCTCCTTAGGGATCTCTTCAAATGAGCAGGACCAAGGATCAGACAA AGGTGAAAATGAAGCAATGGAATCCTCTGGTAAGCGGGCCCCTCAGTGCTACCCCAGTTCCGTCAACTCTGCCAGGACTGTGATGCTGTT CAACCTTGGCAGCGCTTACTGCCTGAGGAGCGAATATGACAAAGCCCGAAAGTGTCTCCACCAGGCGGCTTCAATGATCCATCCTAAAGA GGTGCCCCCTGAGGCCATCTTGCTGGCAGTCTACCTTGAACTGCAGAATGGTAATACTCAGCTGGCCTTACAGATCATCAAAAGGAATCA GCTGCTCCCTGCAGTGAAAACACACTCTGAAGTGAGAAAGAAGCCAGTGTTTCAGCCTGTCCACCCGATCCAGCCCATCCAAATGCCGGC TTTCACCACTGTGCAGAGAAAGTGATACTTCACTTTTGGAAAACTGTTACCTGAGACCCAGGGGAGAATTTACTGGCCATTTTAGTTGTA TCACAGCAGAATGAATAAAAGATGGTGAAGGCTGTTAA >11664_11664_2_C2orf70-CNOT10_C2orf70_chr2_26785554_ENST00000329615_CNOT10_chr3_32800949_ENST00000331889_length(amino acids)=237AA_BP=25 MASRSAGTLLTEFNAAYVPPGLMPGCSILACSAYVALALGDNLMALNHADKLLQQPKLSGSLKFLGHLYAAEALISLDRISDAITHLNPE NVTDVSLGISSNEQDQGSDKGENEAMESSGKRAPQCYPSSVNSARTVMLFNLGSAYCLRSEYDKARKCLHQAASMIHPKEVPPEAILLAV YLELQNGNTQLALQIIKRNQLLPAVKTHSEVRKKPVFQPVHPIQPIQMPAFTTVQRK -------------------------------------------------------------- >11664_11664_3_C2orf70-CNOT10_C2orf70_chr2_26785554_ENST00000329615_CNOT10_chr3_32800949_ENST00000454516_length(transcript)=846nt_BP=105nt GCGCCAGGCTCGCTGTACTCGCGCACCCACCATGGCCTCCCGCAGCGCGGGCACCCTACTGACCGAGTTCAATGCCGCCTACGTGCCCCC TGGACTCATGCCCGGGTGCTCCATACTTGCTTGCAGTGCCTACGTGGCTCTGGCTTTGGGTGATAACCTCATGGCTTTGAATCATGCAGA TAAACTTCTTCAGCAGCCCAAGCTGTCAGGATCTCTTAAGTTTTTGGGACATTTATATGCTGCAGAAGCCCTCATCTCTCTCGACAGAAT ATCTGATGCCATTACTCACTTGAACCCGGAGAATGTCACTGATGTCTCCTTAGGGATCTCTTCAAATGAGCAGGACCAAGGATCAGACAA AGGTGAAAATGAAGCAATGGAATCCTCTGGTAAGCGGGCCCCTCAGTGCTACCCCAGTTCCGTCAACTCTGCCAGGACTGTGATGCTGTT CAACCTTGGCAGCGCTTACTGCCTGAGGAGCGAATATGACAAAGCCCGAAAGTGTCTCCACCAGGCGGCTTCAATGATCCATCCTAAAGA GGTGCCCCCTGAGGCCATCTTGCTGGCAGTCTACCTTGAACTGCAGAATGGTAATACTCAGCTGGCCTTACAGATCATCAAAAGGAATCA GCTGCTCCCTGCAGTGAAAACACACTCTGAAGTGAGAAAGAAGCCAGTGTTTCAGCCTGTCCACCCGATCCAGCCCATCCAAATGCCGGC TTTCACCACTGTGCAGAGAAAGTGATACTTCACTTTTGGAAAACTGTTACCTGAGACCCAGGGGAGAATTTACTGGCCATTTTAGTTGTA TCACAGCAGAATGAATAAAAGATGGTGAAGGCTGTT >11664_11664_3_C2orf70-CNOT10_C2orf70_chr2_26785554_ENST00000329615_CNOT10_chr3_32800949_ENST00000454516_length(amino acids)=237AA_BP=25 MASRSAGTLLTEFNAAYVPPGLMPGCSILACSAYVALALGDNLMALNHADKLLQQPKLSGSLKFLGHLYAAEALISLDRISDAITHLNPE NVTDVSLGISSNEQDQGSDKGENEAMESSGKRAPQCYPSSVNSARTVMLFNLGSAYCLRSEYDKARKCLHQAASMIHPKEVPPEAILLAV YLELQNGNTQLALQIIKRNQLLPAVKTHSEVRKKPVFQPVHPIQPIQMPAFTTVQRK -------------------------------------------------------------- >11664_11664_4_C2orf70-CNOT10_C2orf70_chr2_26785554_ENST00000329615_CNOT10_chr3_32800949_ENST00000538368_length(transcript)=798nt_BP=105nt GCGCCAGGCTCGCTGTACTCGCGCACCCACCATGGCCTCCCGCAGCGCGGGCACCCTACTGACCGAGTTCAATGCCGCCTACGTGCCCCC TGGACTCATGCCCGGGTGCTCCATACTTGCTTGCAGTGCCTACGTGGCTCTGGCTTTGGGTGATAACCTCATGGCTTTGAATCATGCAGA TAAACTTCTTCAGCAGCCCAAGCTGTCAGGATCTCTTAAGTTTTTGGGACATTTATATGCTGCAGAAGCCCTCATCTCTCTCGACAGAAT ATCTGATGCCATTACTCACTTGAACCCGGAGAATGTCACTGATGTCTCCTTAGGGATCTCTTCAAATGAGCAGGACCAAGGTTAATGAGG ACATCTTTGATCAGAACTGGTCACTGTTTCCATTTCCCTCCTGTCATAATTCAGGATGTGTGGAAATTTAGGCATGGTGGTAATGAGAAG AAAGTTTTAGGTTGGCTTTCCACATTTTTGTCTGTACTTACTTTGTAGCAGTTGTTTGCTAAGTAGACCTGAGAGTTAATGATCACATCA TCTAAATTCTCACTTTTGAAAGGCTGGTACTGTTAGAATGGTTAATTTTGGTTCTGATACTATTTATTTGTTTTCCTTTGGAGTGATTCT AAAATCCATAGGGGAGTAAAAATATTGCATTCAAGAGTCAGTTTTAGTCCAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA GGCTGTAGCAGGAGGGTCACTTGAGCCCAAGAGTTCAAGACCAGCCTGGGCAACCTGGTGAGACCCTGTCTCTATTTT >11664_11664_4_C2orf70-CNOT10_C2orf70_chr2_26785554_ENST00000329615_CNOT10_chr3_32800949_ENST00000538368_length(amino acids)=107AA_BP=25 MASRSAGTLLTEFNAAYVPPGLMPGCSILACSAYVALALGDNLMALNHADKLLQQPKLSGSLKFLGHLYAAEALISLDRISDAITHLNPE NVTDVSLGISSNEQDQG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for C2orf70-CNOT10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for C2orf70-CNOT10 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for C2orf70-CNOT10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |