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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FREM2-MTRF1 (FusionGDB2 ID:HG341640TG9617) |
Fusion Gene Summary for FREM2-MTRF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FREM2-MTRF1 | Fusion gene ID: hg341640tg9617 | Hgene | Tgene | Gene symbol | FREM2 | MTRF1 | Gene ID | 341640 | 9617 |
| Gene name | FRAS1 related extracellular matrix 2 | mitochondrial translation release factor 1 | |
| Synonyms | CRYPTOP|FRASRS2 | MRF1|MTTRF1|RF1 | |
| Cytomap | ('FREM2')('MTRF1') 13q13.3 | 13q14.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FRAS1-related extracellular matrix protein 2ECM3 homologFRAS1 related extracellular matrix protein 2 | peptide chain release factor 1, mitochondrialMRF-1mitochondrial translational release factor 1mitochontrial peptide chain release factor 1mtRF-1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q5SZK8 | O75570 | |
| Ensembl transtripts involved in fusion gene | ENST00000280481, ENST00000482551, | ||
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 6 X 6 X 4=144 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FREM2 [Title/Abstract] AND MTRF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FREM2(39438743)-MTRF1(41808143), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | FREM2-MTRF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FREM2-MTRF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across FREM2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MTRF1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-27-1831-01A | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - |
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Fusion Gene ORF analysis for FREM2-MTRF1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000280481 | ENST00000239852 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - |
| In-frame | ENST00000280481 | ENST00000379477 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - |
| In-frame | ENST00000280481 | ENST00000379480 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - |
| In-frame | ENST00000280481 | ENST00000430347 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - |
| intron-3CDS | ENST00000482551 | ENST00000379477 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - |
| intron-3CDS | ENST00000482551 | ENST00000379480 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - |
| intron-3CDS | ENST00000482551 | ENST00000430347 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - |
| intron-intron | ENST00000482551 | ENST00000239852 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000280481 | FREM2 | chr13 | 39438743 | + | ENST00000379480 | MTRF1 | chr13 | 41808143 | - | 9413 | 8199 | 30 | 8666 | 2878 |
| ENST00000280481 | FREM2 | chr13 | 39438743 | + | ENST00000379477 | MTRF1 | chr13 | 41808143 | - | 8807 | 8199 | 30 | 8666 | 2878 |
| ENST00000280481 | FREM2 | chr13 | 39438743 | + | ENST00000430347 | MTRF1 | chr13 | 41808143 | - | 8811 | 8199 | 30 | 8696 | 2888 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000280481 | ENST00000379480 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - | 0.000156619 | 0.99984336 |
| ENST00000280481 | ENST00000379477 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - | 0.000216926 | 0.9997831 |
| ENST00000280481 | ENST00000430347 | FREM2 | chr13 | 39438743 | + | MTRF1 | chr13 | 41808143 | - | 0.000430485 | 0.9995695 |
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Fusion Genomic Features for FREM2-MTRF1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for FREM2-MTRF1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:39438743/chr13:41808143) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FREM2 | MTRF1 |
| FUNCTION: Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (PubMed:15838507). Required for epidermal adhesion (PubMed:15838507). Involved in the development of eyelids and the anterior segment of the eyeballs (PubMed:29688405, PubMed:30802441). {ECO:0000269|PubMed:15838507, ECO:0000269|PubMed:29688405, ECO:0000269|PubMed:30802441}. | FUNCTION: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 1759_1858 | 2661 | 3170.0 | Domain | Note=Calx-beta 1 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 1871_1982 | 2661 | 3170.0 | Domain | Note=Calx-beta 2 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 1997_2103 | 2661 | 3170.0 | Domain | Note=Calx-beta 3 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 2118_2220 | 2661 | 3170.0 | Domain | Note=Calx-beta 4 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 2238_2342 | 2661 | 3170.0 | Domain | Note=Calx-beta 5 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 1066_1168 | 2661 | 3170.0 | Repeat | CSPG 7 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 1189_1282 | 2661 | 3170.0 | Repeat | CSPG 8 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 1303_1399 | 2661 | 3170.0 | Repeat | CSPG 9 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 1420_1512 | 2661 | 3170.0 | Repeat | CSPG 10 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 1532_1621 | 2661 | 3170.0 | Repeat | CSPG 11 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 1655_1752 | 2661 | 3170.0 | Repeat | CSPG 12 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 319_413 | 2661 | 3170.0 | Repeat | CSPG 1 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 438_537 | 2661 | 3170.0 | Repeat | CSPG 2 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 560_675 | 2661 | 3170.0 | Repeat | CSPG 3 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 700_807 | 2661 | 3170.0 | Repeat | CSPG 4 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 828_919 | 2661 | 3170.0 | Repeat | CSPG 5 |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 945_1037 | 2661 | 3170.0 | Repeat | CSPG 6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 3135_3169 | 2661 | 3170.0 | Topological domain | Cytoplasmic |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 47_3113 | 2661 | 3170.0 | Topological domain | Extracellular |
| Hgene | FREM2 | chr13:39438743 | chr13:41808143 | ENST00000280481 | + | 16 | 24 | 3114_3134 | 2661 | 3170.0 | Transmembrane | Helical |
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Fusion Gene Sequence for FREM2-MTRF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >31294_31294_1_FREM2-MTRF1_FREM2_chr13_39438743_ENST00000280481_MTRF1_chr13_41808143_ENST00000379477_length(transcript)=8807nt_BP=8199nt GGACGGCCTGGGAAGGCTTCGGCTCCTCGGCTGCGGCTCCAGCCCGGACGGCGCCGCGCAACTTTGCCATCCTTCTGGCCCAGCCCCGGC TACAGGAGGACCCCGCGGGCAACGCGCGGAGTTCCTGGCACTTCCCGGCGGTGTCTCTTGTTGTCTGCCCGGGGACCGACTTCGCATGCT CTCAGGCTGACCTGTCCAAGCCCGAACACCGGGACCATGCACTCAGCCGGGACTCCCGGGTTATCCTCGCGCCGGACAGGCAACTCCACC AGCTTTCAACCAGGACCGCCACCGCCGCCCCGGCTGCTGCTGCTGCTGCTGCTTCTCCTGTCACTGGTAAGCCGCGTCCCGGCACAGCCC GCTGCCTTCGGCAGGGCGTTGCTGTCCCCTGGTCTCGCGGGGGCTGCAGGGGTCCCTGCTGAGGAGGCCATAGTGCTGGCGAACCGCGGA CTCCGGGTGCCTTTCGGCCGTGAAGTCTGGCTGGATCCCCTGCATGACCTGGTGTTGCAGGTGCAGCCCGGGGACCGCTGCGCGGTTTCG GTACTAGACAACGACGCACTGGCCCAGCGACCGGGCCGCCTGAGTCCCAAGCGCTTCCCGTGCGACTTTGGCCCTGGCGAGGTGCGCTAC TCTCACCTGGGCGCGCGCAGCCCGTCTCGGGACCGCGTCCGGCTGCAGCTGCGCTATGACGCGCCCGGAGGGGCAGTAGTGCTACCACTG GTACTGGAGGTGGAGGTGGTCTTCACCCAGCTGGAGGTTGTGACTCGGAACTTGCCTCTGGTCGTGGAAGAGCTGCTGGGGACCAGCAAT GCCCTGGACGCGCGGAGCCTGGAGTTCGCCTTCCAGCCCGAGACAGAGGAGTGCCGCGTGGGCATCCTGTCCGGCTTGGGCGCGCTGCCT CGCTATGGAGAACTCCTCCACTACCCGCAGGTCCCTGGAGGAGCCAGAGAGGGAGGCGCCCCGGAGACTCTCCTGATGGACTGCAAAGCT TTCCAGGAACTAGGCGTGCGCTATCGCCACACAGCCGCCAGTCGCTCACCAAACAGGGACTGGATACCCATGGTGGTGGAGCTGCGTTCA CGAGGGGCTCCTGTGGGCAGCCCTGCTTTGAAACGCGAGCACTTCCAGGTTCTGGTGAGGATCCGAGGAGGGGCCGAGAACACTGCACCC AAGCCCAGTTTCGTGGCCATGATGATGATGGAGGTGGACCAGTTTGTACTGACGGCCCTGACCCCAGACATGCTGGCAGCCGAGGATGCT GAGTCTCCCTCTGACCTGTTGATCTTCAACCTTACTTCTCCATTCCAGCCTGGCCAGGGCTACTTGGTGAGCACCGATGATCGCAGCCTG CCCCTTTCCTCCTTCACTCAGAGGGATCTGCGGCTCCTGAAGATTGCCTACCAGCCCCCTTCTGAAGACTCTGACCAGGAGCGCCTCTTT GAACTGGAATTGGAGGTAGTGGATCTAGAAGGAGCAGCTTCAGACCCTTTTGCCTTCATGGTAGTGGTGAAGCCCATGAACACAATGGCT CCGGTGGTCACCCGGAATACCGGTCTTATTCTCTATGAGGGTCAGTCTCGGCCCCTCACAGGCCCTGCAGGCAGTGGTCCGCAAAACTTG GTCATCAGCGATGAGGATGACCTAGAAGCAGTGCGGCTAGAGGTGGTGGCTGGGCTCCGGCATGGTCACCTTGTCATTCTGGGTGCTTCC AGTGGCAGCTCTGCTCCCAAGAGCTTTACAGTGGCTGAGCTGGCAGCCGGCCAGGTGGTCTACCAGCATGATGACAGAGACGGCTCGCTG AGCGACAACCTGGTGCTTCGCATGGTGGATGGAGGAGGCAGGCACCAGGTACAGTTTCTGTTCCCCATCACCTTAGTGCCTGTGGATGAC CAGCCACCTGTTCTCAATGCCAACACGGGGCTGACACTGGCAGAGGGTGAAACAGTGCCCATCCTGCCCCTTTCCCTGAGTGCAACTGAC ATGGATTCAGATGATTCTCTGCTGCTTTTTGTGCTGGAGTCACCCTTCTTAACTACGGGGCATCTGCTTCTCCGCCAAACTCACCCTCCC CATGAGAAGCAGGAACTTCTCAGAGGCCTTTGGAGGAAGGAGGGGGCATTTTATGAGCGAACAGTGACAGAGTGGCAGCAGCAGGACATA ACAGAGGGCAGGCTGTTCTATAGACACTCTGGGCCCCATAGTCCTGGGCCAGTCACAGACCAGTTCACATTTAGAGTCCAGGATAACCAT GACCCTCCTAATCAGTCCGGGCTACAGCGGTTTGTGATTCGTATCCATCCTGTGGATCGCCTCCCTCCGGAGCTGGGCAGTGGCTGTCCC CTTCGTATGGTGGTACAGGAATCCCAGCTCACACCACTGAGGAAGAAGTGGCTGCGCTACACTGACCTGGACACAGATGACCGAGAACTA CGTTACACAGTGACTCAGTCCCCCACAGACACAGACGAAAATCACCTGCCAGCCCCACTGGGTACCTTGGTCTTGACTGACAACCCCTCA GTCGTGGTGACCCATTTTACCCAAGCCCAGATCAACCATCATAAAATTGCTTACAGACCCCCGGGTCAAGAACTGGGCGTGGCTACTCGA GTGGCCCAGTTCCAGTTCCAGGTGGAAGACCGAGCTGGGAATGTGGCTCCAGGTACCTTTACCCTTTACTTGCATCCCGTGGACAACCAG CCACCTGAGATCCTCAACACCGGCTTCACTATTCAGGAGAAGGGTCACCACATCCTGAGTGAGACAGAGTTGCACGTGAATGATGTAGAC ACTGATGTTGCCCATATCTCTTTCACTCTCACTCAGGCACCCAAACATGGCCACATGAGAGTGTCTGGACAGATCCTGCATGTAGGGGGT CTCTTCCACTTGGAGGACATAAAACAGGGCCGAGTTTCCTATGCCCATAATGGGGACAAGTCCCTGACTGATAGCTGCTCCTTGGAAGTC AGTGACAGACATCATGTGGTGCCCATCACTCTCAGAGTAAATGTCCGGCCAGTGGATGATGAAGTGCCCATACTGAGCCATCCTACTGGC ACTCTGGAGTCCTATCTAGATGTCTTAGAAAATGGGGCTACTGAAATCACTGCCAATGTTATTAAGGGGACCAATGAGGAAACTGATGAC TTGATGTTGACTTTCCTCTTGGAAGATCCACCTTTGTATGGGGAAATCTTGGTCAATGGCATTCCAGCAGAGCAGTTTACTCAAAGGGAC ATCTTGGAGGGCTCTGTTGTATATACCCACACCAGTGGTGAGATAGGCCTATTGCCTAAAGCGGATTCTTTTAACCTGAGTCTGTCAGAT ATGTCTCAAGAATGGAGAATTGGTGGCAATACTATCCAAGGAGTTACTATATGGGTGACCATCCTGCCTGTTGATAGCCAGGCCCCAGAA ATCTTTGTAGGTGAACAGTTGATAGTAATGGAAGGTGATAAAAGTGTTATAACATCAGTGCATATAAGTGCTGAAGATGTCGACTCCCTG AATGATGACATCTTGTGCACTATAGTTATTCAGCCTACTTCAGGTTATGTTGAAAACATTTCTCCAGCACCAGGCTCTGAGAAATCAAGA GCAGGGATTGCCATAAGTGCTTTCAACTTGAAAGATCTCAGGCAGGGCCACATAAACTATGTCCAGAGTGTCCATAAAGGGGTGGAACCT GTGGAGGACCGATTTGTATTTCGTTGTTCTGATGGCATTAACTTTTCAGAGAGACAGTTCTTCCCCATTGTAATCATTCCCACCAATGAT GAACAGCCAGAGATGTTTATGAGAGAATTTATGGTGATGGAAGGCATGAGTCTGGTAATTGATACACCCATTCTCAATGCTGCTGATGCT GATGTTCCCCTGGATGATTTAACTTTCACTATTACCCAATTCCCCACTCATGGTCACATCATGAATCAGCTGATAAATGGCACGGTTTTG GTCGAAAGCTTCACCTTGGATCAGATCATAGAGAGTTCCAGCATTATTTATGAGCATGATGACTCCGAGACCCAGGAAGACAGTTTTGTG ATTAAACTAACAGATGGGAAGCACTCTGTGGAAAAGACGGTCCTCATTATAGTTATCCCTGTTGATGATGAGACGCCCAGAATGACTATC AATAATGGACTAGAAATAGAAATTGGGGATACCAAGATTATCAACAACAAAATATTAATGGCAACAGATTTAGATTCAGAAGACAAATCT TTGGTTTATATTATTCGTTATGGGCCAGGACATGGCTTATTACAGAGACGAAAACCTACTGGTGCCTTTGAAAATATCACACTGGGCATG AATTTTACCCAGGATGAAGTAGACAGAAACTTAATTCAGTATGTCCATTTGGGGCAAGAGGGCATTCGGGACCTAATTAAATTTGATGTG ACTGATGGAATAAATCCCCTCATAGATCGTTACTTTTATGTGTCCATCGGGAGCATTGACATTGTCTTCCCTGATGTGATAAGTAAGGGA GTGTCCTTGAAAGAAGGTGGCAAAGTCACTCTTACAACAGACCTACTAAGCACTAGTGACTTGAACAGTCCTGATGAAAACTTGGTTTTT ACCATCACCAGGGCTCCCATGCGAGGTCACCTGGAATGCACGGATCAGCCTGGTGTGTCCATCACGTCTTTCACTCAGCTGCAACTGGCT GGAAACAAAATCTACTACATCCACACAGCTGATGATGAAGTGAAAATGGACAGTTTTGAGTTTCAAGTCACCGATGGACGTAACCCTGTC TTTCGGACATTCCGTATCTCCATTAGCGATGTGGACAATAAAAAGCCAGTGGTCACCATCCACAAGCTGGTTGTCAGTGAAAGTGAAAAC AAGCTGATTACTCCTTTTGAGCTCACTGTCGAAGACAGAGATACTCCTGACAAGCTCCTGAAATTCACTATCACCCAGGTGCCTATTCAT GGCCATCTCCTATTCAACAATACCAGACCTGTCATGGTTTTTACCAAGCAAGACTTGAATGAAAACTTAATCAGCTACAAACATGATGGC ACTGAGTCAAGTGAAGATAGCTTCTCCTTCACAGTGACTGATGGCACCCATACAGACTTCTATGTTTTTCCTGATACGGTGTTTGAAACA AGGAGACCCCAAGTGATGAAGATCCAGGTCTTGGCTGTTGACAACAGTGTCCCCCAAATCGCAGTGAATAAGGGGGCCTCTACACTTCGC ACTCTAGCCACTGGCCACTTGGGGTTCATGATCACAAGCAAAATATTGAAAGTGGAGGACAGAGACAGCTTACACATTTCTCTTAGATTT ATCGTGACAGAGGCCCCTCAACATGGATATCTTCTCAACCTGGACAAAGGCAACCACAGCATCACTCAGTTCACACAAGCTGACATTGAT GACATGAAAATATGCTATGTCTTAAGAGAAGGGGCTAATGCCACAAGTGATATGTTCTATTTTGCAGTTGAAGATGGTGGTGGAAACAAG TTAACGTACCAGAATTTTCGTCTGAATTGGGCATGGATCTCCTTTGAAAAGGAATATTACCTGGTCAATGAGGACTCCAAATTTCTAGAT GTTGTTCTTAAACGTAGAGGTTACTTGGGAGAAACTTCTTTTATAAGTATTGGCACAAGAGACAGAACTGCAGAAAAAGACAAAGACTTC AAGGGCAAAGCACAGAAACAAGTGCAGTTCAACCCAGGCCAGACCAGGGCCACATGGCGAGTGCGGATCCTGAGTGATGGGGAGCATGAG CAGTCTGAAACCTTTCAGGTGGTACTCTCAGAGCCCGTGCTGGCTGCCTTGGAATTCCCCACAGTCGCCACTGTTGAGATCGTTGATCCA GGAGATGAGCCAACTGTGTTTATTCCCCAGTCCAAATACTCCGTTGAAGAAGATGTTGGTGAGCTGTTCATTCCCATCAGGAGGAGCGGA GATGTGAGCCAGGAGTTGATGGTGGTCTGTTATACCCAACAAGGAACAGCAACTGGAACTGTGCCGACTTCCGTGTTGTCTTACTCTGAT TACATATCCAGGCCTGAGGACCACACCAGTGTTGTCCGCTTTGACAAAGATGAACGGGAGAAACTGTGTCGGATAGTCATAATTGATGAC TCTTTGTACGAGGAGGAGGAAACCTTCCATGTCCTTCTGAGCATGCCCATGGGGGGAAGAATCGGATCAGAGTTCCCAGGGGCTCAAGTT ACAATCGTTCCTGACAAAGATGATGAACCCATCTTTTACTTCGGTGATGTGGAATACTCTGTGGATGAGAGTGCTGGCTATGTGGAAGTG CAGGTGTGGAGAACGGGCACTGACCTGTCCAAGTCTTCTAGTGTCACAGTGAGGTCTCGGAAAACAGATCCTCCCTCTGCAGATGCTGGA ACAGACTATGTGGGCATCAGCCGTAATTTAGATTTTGCACCTGGAGTCAACATGCAGCCTGTTCGTGTTGTCATTCTGGATGACCTTGGA CAACCAGCGCTGGAGGGAATTGAGAAATTTGAACTGGTGCTTCGCATGCCTATGAACGCAGCCCTTGGCGAGCCCAGCAAAGCCACAGTG TCCATAAATGACTCTGTCTCCGATTTGCCTAAGATGCAATTCAAAGAACGAATATATACTGGCAGCGAAAGTGATGGGCAGATAGTTACA ATGATCCATAGGACTGGGGATGTCCAGTACAGATCTTCAGTGAGATGCTACACCCGGCAGGGGTCTGCACAGGTGATGATGGACTTTGAA GAACGCCCAAACACTGATACCTCCATCATCACATTCCTCCCTGGTGAGACAGAAAAGCCCTGCATTCTTGAGCTGATGGACGATGTGCTC TATGAGGAGGTAGAGGAGCTCCGCCTGGTACTCGGCACTCCACAAAGCAACTCTCCCTTTGGGGCTGCAGTTGGTGAACAAAATGAAACT CTCATAAGGATCCGAGATGATGCTGATAAGACTGTTATTAAATTTGGAGAAACCAAATTTAGTGTCACTGAACCCAAAGAACCTGGAGAG TCGGTGGTTATAAGAATTCCAGTGATTCGCCAAGGAGACACTTCAAAGGTTTCCATTGTGAGAGTCCACACCAAGGATGGCTCGGCCACC TCTGGAGAAGACTACCACCCTGTGTCAGAAGAAATTGAGTTTAAGGAAGGGGAAACCCAGCACGTGGTTGAAATCGAAGTTACCTTTGAC GGGGTGAGAGAGATGAGAGAGGCCTTCACTGTTCACCTAAAACCTGATGAAAATATGATAGCAGAGATGCAGTTGACGAAAGCCATTGTG TACATAGAAGAAATGAGCAGCATGGCAGATGTCACTTTTCCTTCTGTCCCTCAAATTGTATCCCTGTTGATGTATGACGACACTTCCAAA GCTAAGGAGAGTGCTGAACCCATGTCTGGCTATCCTGTCATCTGTATCACAGCTTGCAACCCCAAATATTCAGACTACGATAAAACAGGC TCTATCTGTGCAAGTGAGAACATCAATGACACTTTGACGCGGTACCGGTGGCTGATTAGTGCACCTGCGGGCCCTGACGGTGTGACCAGC CCTATGAGAGAAGTGGACTTCGACACCTTTTTTACGTCATCCAAGATGGTCACACTGGACTCCATATACTTTCAGCCTGGCTCCCGGGTA CAGTGCGCAGCTCGTGCTGTGAACACCAATGGGGATGAAGGCCTGGAGCTCATGAGCCCTATTGTAACCATCAGCAGAGAAGAAGGTCTT TGTCAGCCCCGTGTACCTGGGGTTGTTGGAGCAGAGCCGTTCTCAGCTAAATTGCGCTACACAGGCCCTGAGGATGCAGACTACACAAAC CTTATCAAGCTCACTGTCACAATGCCACACATAGATGGCATGCTCCCCGTGATCTCCACTAGAGAGCTTTCCAACTTTGAGCTCACCCTC AGCCCTGATGGCACAAGAGTTGGAAACCACAAGTGCTCCAACCTCCTGGATTATACTGAAGTGAAGACTCATTATGGTTTCTTGACTGAT GCTACCAAAAATCCAGAAATAATTGGAGAGACATATCCTTACCAGTACAGCTTGTCCATCAGAGGTTCCACTACCTTGCGCTTCTACCGG AACCTGAACCTAGAGGCCTGTTTATGGGAGTTCGTTAGCTACTATGACATGTCAGAACTCCTTGCTGACTGTGGTGGCACCATTGGAACA GATGGACAGGTGGATGTGAAATTGGACCCCAAGGATTTGCGAATAGATACATTTCGAGCCAAAGGAGCAGGAGGGCAGCATGTTAATAAA ACTGATAGTGCCGTCAGACTTGTCCACATCCCCACAGGGCTAGTAGTAGAATGCCAACAAGAAAGATCACAGATAAAAAATAAAGAAATA GCCTTTCGTGTGTTGAGAGCTAGACTCTACCAGCAGATTATTGAGAAAGACAAGCGTCAGCAACAAAGTGCTAGAAAACTGCAGGTGGGA ACAAGAGCCCAGTCAGAGCGAATTCGGACATATAATTTCACCCAGGATAGAGTCAGTGACCACAGGATAGCATATGAAGTTCGTGATATT AAGGAATTTTTATGTGGTGGGAAGGGCCTGGATCAGCTAATTCAGAGACTGCTTCAATCAGCAGATGAAGAAGCCATTGCTGAACTTTTG GATGAACACCTTAAATCAGCAAAATAAATACTAACTTATTATTATTTATGATTATATAAATGAAATGGACCTATATCAAGAGGCAGACTG >31294_31294_1_FREM2-MTRF1_FREM2_chr13_39438743_ENST00000280481_MTRF1_chr13_41808143_ENST00000379477_length(amino acids)=2878AA_BP=2723 MRLQPGRRRATLPSFWPSPGYRRTPRATRGVPGTSRRCLLLSARGPTSHALRLTCPSPNTGTMHSAGTPGLSSRRTGNSTSFQPGPPPPP RLLLLLLLLLSLVSRVPAQPAAFGRALLSPGLAGAAGVPAEEAIVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQR PGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFA FQPETEECRVGILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRSRGAPVGSPAL KREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDRSLPLSSFTQRDL RLLKIAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEA VRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNANTG LTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHS GPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTD TDENHLPAPLGTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTFTLYLHPVDNQPPEILNTGFT IQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRHHVVPIT LRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTH TSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVI QPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREF MVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSV EKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRN LIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGH LECTDQPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTV EDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQV LAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLRE GANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQF NPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVC YTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEP IFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKF ELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSII TFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIR QGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMAD VTFPSVPQIVSLLMYDDTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICASENINDTLTRYRWLISAPAGPDGVTSPMREVDFDTF FTSSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAEPFSAKLRYTGPEDADYTNLIKLTVTMPH IDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHYGFLTDATKNPEIIGETYPYQYSLSIRGSTTLRFYRNLNLEACLWE FVSYYDMSELLADCGGTIGTDGQVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLY -------------------------------------------------------------- >31294_31294_2_FREM2-MTRF1_FREM2_chr13_39438743_ENST00000280481_MTRF1_chr13_41808143_ENST00000379480_length(transcript)=9413nt_BP=8199nt GGACGGCCTGGGAAGGCTTCGGCTCCTCGGCTGCGGCTCCAGCCCGGACGGCGCCGCGCAACTTTGCCATCCTTCTGGCCCAGCCCCGGC TACAGGAGGACCCCGCGGGCAACGCGCGGAGTTCCTGGCACTTCCCGGCGGTGTCTCTTGTTGTCTGCCCGGGGACCGACTTCGCATGCT CTCAGGCTGACCTGTCCAAGCCCGAACACCGGGACCATGCACTCAGCCGGGACTCCCGGGTTATCCTCGCGCCGGACAGGCAACTCCACC AGCTTTCAACCAGGACCGCCACCGCCGCCCCGGCTGCTGCTGCTGCTGCTGCTTCTCCTGTCACTGGTAAGCCGCGTCCCGGCACAGCCC GCTGCCTTCGGCAGGGCGTTGCTGTCCCCTGGTCTCGCGGGGGCTGCAGGGGTCCCTGCTGAGGAGGCCATAGTGCTGGCGAACCGCGGA CTCCGGGTGCCTTTCGGCCGTGAAGTCTGGCTGGATCCCCTGCATGACCTGGTGTTGCAGGTGCAGCCCGGGGACCGCTGCGCGGTTTCG GTACTAGACAACGACGCACTGGCCCAGCGACCGGGCCGCCTGAGTCCCAAGCGCTTCCCGTGCGACTTTGGCCCTGGCGAGGTGCGCTAC TCTCACCTGGGCGCGCGCAGCCCGTCTCGGGACCGCGTCCGGCTGCAGCTGCGCTATGACGCGCCCGGAGGGGCAGTAGTGCTACCACTG GTACTGGAGGTGGAGGTGGTCTTCACCCAGCTGGAGGTTGTGACTCGGAACTTGCCTCTGGTCGTGGAAGAGCTGCTGGGGACCAGCAAT GCCCTGGACGCGCGGAGCCTGGAGTTCGCCTTCCAGCCCGAGACAGAGGAGTGCCGCGTGGGCATCCTGTCCGGCTTGGGCGCGCTGCCT CGCTATGGAGAACTCCTCCACTACCCGCAGGTCCCTGGAGGAGCCAGAGAGGGAGGCGCCCCGGAGACTCTCCTGATGGACTGCAAAGCT TTCCAGGAACTAGGCGTGCGCTATCGCCACACAGCCGCCAGTCGCTCACCAAACAGGGACTGGATACCCATGGTGGTGGAGCTGCGTTCA CGAGGGGCTCCTGTGGGCAGCCCTGCTTTGAAACGCGAGCACTTCCAGGTTCTGGTGAGGATCCGAGGAGGGGCCGAGAACACTGCACCC AAGCCCAGTTTCGTGGCCATGATGATGATGGAGGTGGACCAGTTTGTACTGACGGCCCTGACCCCAGACATGCTGGCAGCCGAGGATGCT GAGTCTCCCTCTGACCTGTTGATCTTCAACCTTACTTCTCCATTCCAGCCTGGCCAGGGCTACTTGGTGAGCACCGATGATCGCAGCCTG CCCCTTTCCTCCTTCACTCAGAGGGATCTGCGGCTCCTGAAGATTGCCTACCAGCCCCCTTCTGAAGACTCTGACCAGGAGCGCCTCTTT GAACTGGAATTGGAGGTAGTGGATCTAGAAGGAGCAGCTTCAGACCCTTTTGCCTTCATGGTAGTGGTGAAGCCCATGAACACAATGGCT CCGGTGGTCACCCGGAATACCGGTCTTATTCTCTATGAGGGTCAGTCTCGGCCCCTCACAGGCCCTGCAGGCAGTGGTCCGCAAAACTTG GTCATCAGCGATGAGGATGACCTAGAAGCAGTGCGGCTAGAGGTGGTGGCTGGGCTCCGGCATGGTCACCTTGTCATTCTGGGTGCTTCC AGTGGCAGCTCTGCTCCCAAGAGCTTTACAGTGGCTGAGCTGGCAGCCGGCCAGGTGGTCTACCAGCATGATGACAGAGACGGCTCGCTG AGCGACAACCTGGTGCTTCGCATGGTGGATGGAGGAGGCAGGCACCAGGTACAGTTTCTGTTCCCCATCACCTTAGTGCCTGTGGATGAC CAGCCACCTGTTCTCAATGCCAACACGGGGCTGACACTGGCAGAGGGTGAAACAGTGCCCATCCTGCCCCTTTCCCTGAGTGCAACTGAC ATGGATTCAGATGATTCTCTGCTGCTTTTTGTGCTGGAGTCACCCTTCTTAACTACGGGGCATCTGCTTCTCCGCCAAACTCACCCTCCC CATGAGAAGCAGGAACTTCTCAGAGGCCTTTGGAGGAAGGAGGGGGCATTTTATGAGCGAACAGTGACAGAGTGGCAGCAGCAGGACATA ACAGAGGGCAGGCTGTTCTATAGACACTCTGGGCCCCATAGTCCTGGGCCAGTCACAGACCAGTTCACATTTAGAGTCCAGGATAACCAT GACCCTCCTAATCAGTCCGGGCTACAGCGGTTTGTGATTCGTATCCATCCTGTGGATCGCCTCCCTCCGGAGCTGGGCAGTGGCTGTCCC CTTCGTATGGTGGTACAGGAATCCCAGCTCACACCACTGAGGAAGAAGTGGCTGCGCTACACTGACCTGGACACAGATGACCGAGAACTA CGTTACACAGTGACTCAGTCCCCCACAGACACAGACGAAAATCACCTGCCAGCCCCACTGGGTACCTTGGTCTTGACTGACAACCCCTCA GTCGTGGTGACCCATTTTACCCAAGCCCAGATCAACCATCATAAAATTGCTTACAGACCCCCGGGTCAAGAACTGGGCGTGGCTACTCGA GTGGCCCAGTTCCAGTTCCAGGTGGAAGACCGAGCTGGGAATGTGGCTCCAGGTACCTTTACCCTTTACTTGCATCCCGTGGACAACCAG CCACCTGAGATCCTCAACACCGGCTTCACTATTCAGGAGAAGGGTCACCACATCCTGAGTGAGACAGAGTTGCACGTGAATGATGTAGAC ACTGATGTTGCCCATATCTCTTTCACTCTCACTCAGGCACCCAAACATGGCCACATGAGAGTGTCTGGACAGATCCTGCATGTAGGGGGT CTCTTCCACTTGGAGGACATAAAACAGGGCCGAGTTTCCTATGCCCATAATGGGGACAAGTCCCTGACTGATAGCTGCTCCTTGGAAGTC AGTGACAGACATCATGTGGTGCCCATCACTCTCAGAGTAAATGTCCGGCCAGTGGATGATGAAGTGCCCATACTGAGCCATCCTACTGGC ACTCTGGAGTCCTATCTAGATGTCTTAGAAAATGGGGCTACTGAAATCACTGCCAATGTTATTAAGGGGACCAATGAGGAAACTGATGAC TTGATGTTGACTTTCCTCTTGGAAGATCCACCTTTGTATGGGGAAATCTTGGTCAATGGCATTCCAGCAGAGCAGTTTACTCAAAGGGAC ATCTTGGAGGGCTCTGTTGTATATACCCACACCAGTGGTGAGATAGGCCTATTGCCTAAAGCGGATTCTTTTAACCTGAGTCTGTCAGAT ATGTCTCAAGAATGGAGAATTGGTGGCAATACTATCCAAGGAGTTACTATATGGGTGACCATCCTGCCTGTTGATAGCCAGGCCCCAGAA ATCTTTGTAGGTGAACAGTTGATAGTAATGGAAGGTGATAAAAGTGTTATAACATCAGTGCATATAAGTGCTGAAGATGTCGACTCCCTG AATGATGACATCTTGTGCACTATAGTTATTCAGCCTACTTCAGGTTATGTTGAAAACATTTCTCCAGCACCAGGCTCTGAGAAATCAAGA GCAGGGATTGCCATAAGTGCTTTCAACTTGAAAGATCTCAGGCAGGGCCACATAAACTATGTCCAGAGTGTCCATAAAGGGGTGGAACCT GTGGAGGACCGATTTGTATTTCGTTGTTCTGATGGCATTAACTTTTCAGAGAGACAGTTCTTCCCCATTGTAATCATTCCCACCAATGAT GAACAGCCAGAGATGTTTATGAGAGAATTTATGGTGATGGAAGGCATGAGTCTGGTAATTGATACACCCATTCTCAATGCTGCTGATGCT GATGTTCCCCTGGATGATTTAACTTTCACTATTACCCAATTCCCCACTCATGGTCACATCATGAATCAGCTGATAAATGGCACGGTTTTG GTCGAAAGCTTCACCTTGGATCAGATCATAGAGAGTTCCAGCATTATTTATGAGCATGATGACTCCGAGACCCAGGAAGACAGTTTTGTG ATTAAACTAACAGATGGGAAGCACTCTGTGGAAAAGACGGTCCTCATTATAGTTATCCCTGTTGATGATGAGACGCCCAGAATGACTATC AATAATGGACTAGAAATAGAAATTGGGGATACCAAGATTATCAACAACAAAATATTAATGGCAACAGATTTAGATTCAGAAGACAAATCT TTGGTTTATATTATTCGTTATGGGCCAGGACATGGCTTATTACAGAGACGAAAACCTACTGGTGCCTTTGAAAATATCACACTGGGCATG AATTTTACCCAGGATGAAGTAGACAGAAACTTAATTCAGTATGTCCATTTGGGGCAAGAGGGCATTCGGGACCTAATTAAATTTGATGTG ACTGATGGAATAAATCCCCTCATAGATCGTTACTTTTATGTGTCCATCGGGAGCATTGACATTGTCTTCCCTGATGTGATAAGTAAGGGA GTGTCCTTGAAAGAAGGTGGCAAAGTCACTCTTACAACAGACCTACTAAGCACTAGTGACTTGAACAGTCCTGATGAAAACTTGGTTTTT ACCATCACCAGGGCTCCCATGCGAGGTCACCTGGAATGCACGGATCAGCCTGGTGTGTCCATCACGTCTTTCACTCAGCTGCAACTGGCT GGAAACAAAATCTACTACATCCACACAGCTGATGATGAAGTGAAAATGGACAGTTTTGAGTTTCAAGTCACCGATGGACGTAACCCTGTC TTTCGGACATTCCGTATCTCCATTAGCGATGTGGACAATAAAAAGCCAGTGGTCACCATCCACAAGCTGGTTGTCAGTGAAAGTGAAAAC AAGCTGATTACTCCTTTTGAGCTCACTGTCGAAGACAGAGATACTCCTGACAAGCTCCTGAAATTCACTATCACCCAGGTGCCTATTCAT GGCCATCTCCTATTCAACAATACCAGACCTGTCATGGTTTTTACCAAGCAAGACTTGAATGAAAACTTAATCAGCTACAAACATGATGGC ACTGAGTCAAGTGAAGATAGCTTCTCCTTCACAGTGACTGATGGCACCCATACAGACTTCTATGTTTTTCCTGATACGGTGTTTGAAACA AGGAGACCCCAAGTGATGAAGATCCAGGTCTTGGCTGTTGACAACAGTGTCCCCCAAATCGCAGTGAATAAGGGGGCCTCTACACTTCGC ACTCTAGCCACTGGCCACTTGGGGTTCATGATCACAAGCAAAATATTGAAAGTGGAGGACAGAGACAGCTTACACATTTCTCTTAGATTT ATCGTGACAGAGGCCCCTCAACATGGATATCTTCTCAACCTGGACAAAGGCAACCACAGCATCACTCAGTTCACACAAGCTGACATTGAT GACATGAAAATATGCTATGTCTTAAGAGAAGGGGCTAATGCCACAAGTGATATGTTCTATTTTGCAGTTGAAGATGGTGGTGGAAACAAG TTAACGTACCAGAATTTTCGTCTGAATTGGGCATGGATCTCCTTTGAAAAGGAATATTACCTGGTCAATGAGGACTCCAAATTTCTAGAT GTTGTTCTTAAACGTAGAGGTTACTTGGGAGAAACTTCTTTTATAAGTATTGGCACAAGAGACAGAACTGCAGAAAAAGACAAAGACTTC AAGGGCAAAGCACAGAAACAAGTGCAGTTCAACCCAGGCCAGACCAGGGCCACATGGCGAGTGCGGATCCTGAGTGATGGGGAGCATGAG CAGTCTGAAACCTTTCAGGTGGTACTCTCAGAGCCCGTGCTGGCTGCCTTGGAATTCCCCACAGTCGCCACTGTTGAGATCGTTGATCCA GGAGATGAGCCAACTGTGTTTATTCCCCAGTCCAAATACTCCGTTGAAGAAGATGTTGGTGAGCTGTTCATTCCCATCAGGAGGAGCGGA GATGTGAGCCAGGAGTTGATGGTGGTCTGTTATACCCAACAAGGAACAGCAACTGGAACTGTGCCGACTTCCGTGTTGTCTTACTCTGAT TACATATCCAGGCCTGAGGACCACACCAGTGTTGTCCGCTTTGACAAAGATGAACGGGAGAAACTGTGTCGGATAGTCATAATTGATGAC TCTTTGTACGAGGAGGAGGAAACCTTCCATGTCCTTCTGAGCATGCCCATGGGGGGAAGAATCGGATCAGAGTTCCCAGGGGCTCAAGTT ACAATCGTTCCTGACAAAGATGATGAACCCATCTTTTACTTCGGTGATGTGGAATACTCTGTGGATGAGAGTGCTGGCTATGTGGAAGTG CAGGTGTGGAGAACGGGCACTGACCTGTCCAAGTCTTCTAGTGTCACAGTGAGGTCTCGGAAAACAGATCCTCCCTCTGCAGATGCTGGA ACAGACTATGTGGGCATCAGCCGTAATTTAGATTTTGCACCTGGAGTCAACATGCAGCCTGTTCGTGTTGTCATTCTGGATGACCTTGGA CAACCAGCGCTGGAGGGAATTGAGAAATTTGAACTGGTGCTTCGCATGCCTATGAACGCAGCCCTTGGCGAGCCCAGCAAAGCCACAGTG TCCATAAATGACTCTGTCTCCGATTTGCCTAAGATGCAATTCAAAGAACGAATATATACTGGCAGCGAAAGTGATGGGCAGATAGTTACA ATGATCCATAGGACTGGGGATGTCCAGTACAGATCTTCAGTGAGATGCTACACCCGGCAGGGGTCTGCACAGGTGATGATGGACTTTGAA GAACGCCCAAACACTGATACCTCCATCATCACATTCCTCCCTGGTGAGACAGAAAAGCCCTGCATTCTTGAGCTGATGGACGATGTGCTC TATGAGGAGGTAGAGGAGCTCCGCCTGGTACTCGGCACTCCACAAAGCAACTCTCCCTTTGGGGCTGCAGTTGGTGAACAAAATGAAACT CTCATAAGGATCCGAGATGATGCTGATAAGACTGTTATTAAATTTGGAGAAACCAAATTTAGTGTCACTGAACCCAAAGAACCTGGAGAG TCGGTGGTTATAAGAATTCCAGTGATTCGCCAAGGAGACACTTCAAAGGTTTCCATTGTGAGAGTCCACACCAAGGATGGCTCGGCCACC TCTGGAGAAGACTACCACCCTGTGTCAGAAGAAATTGAGTTTAAGGAAGGGGAAACCCAGCACGTGGTTGAAATCGAAGTTACCTTTGAC GGGGTGAGAGAGATGAGAGAGGCCTTCACTGTTCACCTAAAACCTGATGAAAATATGATAGCAGAGATGCAGTTGACGAAAGCCATTGTG TACATAGAAGAAATGAGCAGCATGGCAGATGTCACTTTTCCTTCTGTCCCTCAAATTGTATCCCTGTTGATGTATGACGACACTTCCAAA GCTAAGGAGAGTGCTGAACCCATGTCTGGCTATCCTGTCATCTGTATCACAGCTTGCAACCCCAAATATTCAGACTACGATAAAACAGGC TCTATCTGTGCAAGTGAGAACATCAATGACACTTTGACGCGGTACCGGTGGCTGATTAGTGCACCTGCGGGCCCTGACGGTGTGACCAGC CCTATGAGAGAAGTGGACTTCGACACCTTTTTTACGTCATCCAAGATGGTCACACTGGACTCCATATACTTTCAGCCTGGCTCCCGGGTA CAGTGCGCAGCTCGTGCTGTGAACACCAATGGGGATGAAGGCCTGGAGCTCATGAGCCCTATTGTAACCATCAGCAGAGAAGAAGGTCTT TGTCAGCCCCGTGTACCTGGGGTTGTTGGAGCAGAGCCGTTCTCAGCTAAATTGCGCTACACAGGCCCTGAGGATGCAGACTACACAAAC CTTATCAAGCTCACTGTCACAATGCCACACATAGATGGCATGCTCCCCGTGATCTCCACTAGAGAGCTTTCCAACTTTGAGCTCACCCTC AGCCCTGATGGCACAAGAGTTGGAAACCACAAGTGCTCCAACCTCCTGGATTATACTGAAGTGAAGACTCATTATGGTTTCTTGACTGAT GCTACCAAAAATCCAGAAATAATTGGAGAGACATATCCTTACCAGTACAGCTTGTCCATCAGAGGTTCCACTACCTTGCGCTTCTACCGG AACCTGAACCTAGAGGCCTGTTTATGGGAGTTCGTTAGCTACTATGACATGTCAGAACTCCTTGCTGACTGTGGTGGCACCATTGGAACA GATGGACAGGTGGATGTGAAATTGGACCCCAAGGATTTGCGAATAGATACATTTCGAGCCAAAGGAGCAGGAGGGCAGCATGTTAATAAA ACTGATAGTGCCGTCAGACTTGTCCACATCCCCACAGGGCTAGTAGTAGAATGCCAACAAGAAAGATCACAGATAAAAAATAAAGAAATA GCCTTTCGTGTGTTGAGAGCTAGACTCTACCAGCAGATTATTGAGAAAGACAAGCGTCAGCAACAAAGTGCTAGAAAACTGCAGGTGGGA ACAAGAGCCCAGTCAGAGCGAATTCGGACATATAATTTCACCCAGGATAGAGTCAGTGACCACAGGATAGCATATGAAGTTCGTGATATT AAGGAATTTTTATGTGGTGGGAAGGGCCTGGATCAGCTAATTCAGAGACTGCTTCAATCAGCAGATGAAGAAGCCATTGCTGAACTTTTG GATGAACACCTTAAATCAGCAAAATAAATACTAACTTATTATTATTTATGATTATATAAATGAAATGGACCTATATCAAGAGGCAGACTG AAGCTTGGAAATCATTATGAATATTTGTAAATTACAGCTTTAAGAACACATTACACATAAATATATGTTTTGTAATTAATCGAAGTCACA TTTCCTGACCTAAGAATTTATTTTAGGTTTCCTGTAAAGTACAATCCAACTCATCAAGTAGAAAATAAGCATGCATCATTGAAAAGAGAA AGTATTGAGAATTGATTGTGTCATTTAGGACAAGTCACTTGTTCTCTTTATATGCCTTTTTTCCCCAGCCATCTATGAATTAATTTAAAT ATATTTTTAATCTACTACTTCAGGAAAATATGGTAAAATTTAGTAAAATATGAATTTTAGACTTCCTTATAAACCTTTTATTTAAATACA AAGTACCTTGGCCTATAGTGGATGCTTATGCCTGTAATCCCAGTGCTTTGAAGGGCCAAAGGGGGAAGATCTCTTGAGGTAAGAATTTGA GACCAGCCTGGGCAAAATAGACCCCATGTCTACAAAAAAACTCAAAACATAAAGAAAAACCATAATACTGTTAATCATGTTAAAGTTAAG ACTTAGACTGCAACTTTTAAATAAAAATTATGAAGAATATGAGTCATTCAATAACAATGAGCATCTGGGTACAGACAGTAAAGCCCTTTG >31294_31294_2_FREM2-MTRF1_FREM2_chr13_39438743_ENST00000280481_MTRF1_chr13_41808143_ENST00000379480_length(amino acids)=2878AA_BP=2723 MRLQPGRRRATLPSFWPSPGYRRTPRATRGVPGTSRRCLLLSARGPTSHALRLTCPSPNTGTMHSAGTPGLSSRRTGNSTSFQPGPPPPP RLLLLLLLLLSLVSRVPAQPAAFGRALLSPGLAGAAGVPAEEAIVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQR PGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFA FQPETEECRVGILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRSRGAPVGSPAL KREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDRSLPLSSFTQRDL RLLKIAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEA VRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNANTG LTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHS GPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTD TDENHLPAPLGTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTFTLYLHPVDNQPPEILNTGFT IQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRHHVVPIT LRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTH TSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVI QPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREF MVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSV EKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRN LIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGH LECTDQPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTV EDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQV LAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLRE GANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQF NPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVC YTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEP IFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKF ELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSII TFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIR QGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMAD VTFPSVPQIVSLLMYDDTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICASENINDTLTRYRWLISAPAGPDGVTSPMREVDFDTF FTSSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAEPFSAKLRYTGPEDADYTNLIKLTVTMPH IDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHYGFLTDATKNPEIIGETYPYQYSLSIRGSTTLRFYRNLNLEACLWE FVSYYDMSELLADCGGTIGTDGQVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLY -------------------------------------------------------------- >31294_31294_3_FREM2-MTRF1_FREM2_chr13_39438743_ENST00000280481_MTRF1_chr13_41808143_ENST00000430347_length(transcript)=8811nt_BP=8199nt GGACGGCCTGGGAAGGCTTCGGCTCCTCGGCTGCGGCTCCAGCCCGGACGGCGCCGCGCAACTTTGCCATCCTTCTGGCCCAGCCCCGGC TACAGGAGGACCCCGCGGGCAACGCGCGGAGTTCCTGGCACTTCCCGGCGGTGTCTCTTGTTGTCTGCCCGGGGACCGACTTCGCATGCT CTCAGGCTGACCTGTCCAAGCCCGAACACCGGGACCATGCACTCAGCCGGGACTCCCGGGTTATCCTCGCGCCGGACAGGCAACTCCACC AGCTTTCAACCAGGACCGCCACCGCCGCCCCGGCTGCTGCTGCTGCTGCTGCTTCTCCTGTCACTGGTAAGCCGCGTCCCGGCACAGCCC GCTGCCTTCGGCAGGGCGTTGCTGTCCCCTGGTCTCGCGGGGGCTGCAGGGGTCCCTGCTGAGGAGGCCATAGTGCTGGCGAACCGCGGA CTCCGGGTGCCTTTCGGCCGTGAAGTCTGGCTGGATCCCCTGCATGACCTGGTGTTGCAGGTGCAGCCCGGGGACCGCTGCGCGGTTTCG GTACTAGACAACGACGCACTGGCCCAGCGACCGGGCCGCCTGAGTCCCAAGCGCTTCCCGTGCGACTTTGGCCCTGGCGAGGTGCGCTAC TCTCACCTGGGCGCGCGCAGCCCGTCTCGGGACCGCGTCCGGCTGCAGCTGCGCTATGACGCGCCCGGAGGGGCAGTAGTGCTACCACTG GTACTGGAGGTGGAGGTGGTCTTCACCCAGCTGGAGGTTGTGACTCGGAACTTGCCTCTGGTCGTGGAAGAGCTGCTGGGGACCAGCAAT GCCCTGGACGCGCGGAGCCTGGAGTTCGCCTTCCAGCCCGAGACAGAGGAGTGCCGCGTGGGCATCCTGTCCGGCTTGGGCGCGCTGCCT CGCTATGGAGAACTCCTCCACTACCCGCAGGTCCCTGGAGGAGCCAGAGAGGGAGGCGCCCCGGAGACTCTCCTGATGGACTGCAAAGCT TTCCAGGAACTAGGCGTGCGCTATCGCCACACAGCCGCCAGTCGCTCACCAAACAGGGACTGGATACCCATGGTGGTGGAGCTGCGTTCA CGAGGGGCTCCTGTGGGCAGCCCTGCTTTGAAACGCGAGCACTTCCAGGTTCTGGTGAGGATCCGAGGAGGGGCCGAGAACACTGCACCC AAGCCCAGTTTCGTGGCCATGATGATGATGGAGGTGGACCAGTTTGTACTGACGGCCCTGACCCCAGACATGCTGGCAGCCGAGGATGCT GAGTCTCCCTCTGACCTGTTGATCTTCAACCTTACTTCTCCATTCCAGCCTGGCCAGGGCTACTTGGTGAGCACCGATGATCGCAGCCTG CCCCTTTCCTCCTTCACTCAGAGGGATCTGCGGCTCCTGAAGATTGCCTACCAGCCCCCTTCTGAAGACTCTGACCAGGAGCGCCTCTTT GAACTGGAATTGGAGGTAGTGGATCTAGAAGGAGCAGCTTCAGACCCTTTTGCCTTCATGGTAGTGGTGAAGCCCATGAACACAATGGCT CCGGTGGTCACCCGGAATACCGGTCTTATTCTCTATGAGGGTCAGTCTCGGCCCCTCACAGGCCCTGCAGGCAGTGGTCCGCAAAACTTG GTCATCAGCGATGAGGATGACCTAGAAGCAGTGCGGCTAGAGGTGGTGGCTGGGCTCCGGCATGGTCACCTTGTCATTCTGGGTGCTTCC AGTGGCAGCTCTGCTCCCAAGAGCTTTACAGTGGCTGAGCTGGCAGCCGGCCAGGTGGTCTACCAGCATGATGACAGAGACGGCTCGCTG AGCGACAACCTGGTGCTTCGCATGGTGGATGGAGGAGGCAGGCACCAGGTACAGTTTCTGTTCCCCATCACCTTAGTGCCTGTGGATGAC CAGCCACCTGTTCTCAATGCCAACACGGGGCTGACACTGGCAGAGGGTGAAACAGTGCCCATCCTGCCCCTTTCCCTGAGTGCAACTGAC ATGGATTCAGATGATTCTCTGCTGCTTTTTGTGCTGGAGTCACCCTTCTTAACTACGGGGCATCTGCTTCTCCGCCAAACTCACCCTCCC CATGAGAAGCAGGAACTTCTCAGAGGCCTTTGGAGGAAGGAGGGGGCATTTTATGAGCGAACAGTGACAGAGTGGCAGCAGCAGGACATA ACAGAGGGCAGGCTGTTCTATAGACACTCTGGGCCCCATAGTCCTGGGCCAGTCACAGACCAGTTCACATTTAGAGTCCAGGATAACCAT GACCCTCCTAATCAGTCCGGGCTACAGCGGTTTGTGATTCGTATCCATCCTGTGGATCGCCTCCCTCCGGAGCTGGGCAGTGGCTGTCCC CTTCGTATGGTGGTACAGGAATCCCAGCTCACACCACTGAGGAAGAAGTGGCTGCGCTACACTGACCTGGACACAGATGACCGAGAACTA CGTTACACAGTGACTCAGTCCCCCACAGACACAGACGAAAATCACCTGCCAGCCCCACTGGGTACCTTGGTCTTGACTGACAACCCCTCA GTCGTGGTGACCCATTTTACCCAAGCCCAGATCAACCATCATAAAATTGCTTACAGACCCCCGGGTCAAGAACTGGGCGTGGCTACTCGA GTGGCCCAGTTCCAGTTCCAGGTGGAAGACCGAGCTGGGAATGTGGCTCCAGGTACCTTTACCCTTTACTTGCATCCCGTGGACAACCAG CCACCTGAGATCCTCAACACCGGCTTCACTATTCAGGAGAAGGGTCACCACATCCTGAGTGAGACAGAGTTGCACGTGAATGATGTAGAC ACTGATGTTGCCCATATCTCTTTCACTCTCACTCAGGCACCCAAACATGGCCACATGAGAGTGTCTGGACAGATCCTGCATGTAGGGGGT CTCTTCCACTTGGAGGACATAAAACAGGGCCGAGTTTCCTATGCCCATAATGGGGACAAGTCCCTGACTGATAGCTGCTCCTTGGAAGTC AGTGACAGACATCATGTGGTGCCCATCACTCTCAGAGTAAATGTCCGGCCAGTGGATGATGAAGTGCCCATACTGAGCCATCCTACTGGC ACTCTGGAGTCCTATCTAGATGTCTTAGAAAATGGGGCTACTGAAATCACTGCCAATGTTATTAAGGGGACCAATGAGGAAACTGATGAC TTGATGTTGACTTTCCTCTTGGAAGATCCACCTTTGTATGGGGAAATCTTGGTCAATGGCATTCCAGCAGAGCAGTTTACTCAAAGGGAC ATCTTGGAGGGCTCTGTTGTATATACCCACACCAGTGGTGAGATAGGCCTATTGCCTAAAGCGGATTCTTTTAACCTGAGTCTGTCAGAT ATGTCTCAAGAATGGAGAATTGGTGGCAATACTATCCAAGGAGTTACTATATGGGTGACCATCCTGCCTGTTGATAGCCAGGCCCCAGAA ATCTTTGTAGGTGAACAGTTGATAGTAATGGAAGGTGATAAAAGTGTTATAACATCAGTGCATATAAGTGCTGAAGATGTCGACTCCCTG AATGATGACATCTTGTGCACTATAGTTATTCAGCCTACTTCAGGTTATGTTGAAAACATTTCTCCAGCACCAGGCTCTGAGAAATCAAGA GCAGGGATTGCCATAAGTGCTTTCAACTTGAAAGATCTCAGGCAGGGCCACATAAACTATGTCCAGAGTGTCCATAAAGGGGTGGAACCT GTGGAGGACCGATTTGTATTTCGTTGTTCTGATGGCATTAACTTTTCAGAGAGACAGTTCTTCCCCATTGTAATCATTCCCACCAATGAT GAACAGCCAGAGATGTTTATGAGAGAATTTATGGTGATGGAAGGCATGAGTCTGGTAATTGATACACCCATTCTCAATGCTGCTGATGCT GATGTTCCCCTGGATGATTTAACTTTCACTATTACCCAATTCCCCACTCATGGTCACATCATGAATCAGCTGATAAATGGCACGGTTTTG GTCGAAAGCTTCACCTTGGATCAGATCATAGAGAGTTCCAGCATTATTTATGAGCATGATGACTCCGAGACCCAGGAAGACAGTTTTGTG ATTAAACTAACAGATGGGAAGCACTCTGTGGAAAAGACGGTCCTCATTATAGTTATCCCTGTTGATGATGAGACGCCCAGAATGACTATC AATAATGGACTAGAAATAGAAATTGGGGATACCAAGATTATCAACAACAAAATATTAATGGCAACAGATTTAGATTCAGAAGACAAATCT TTGGTTTATATTATTCGTTATGGGCCAGGACATGGCTTATTACAGAGACGAAAACCTACTGGTGCCTTTGAAAATATCACACTGGGCATG AATTTTACCCAGGATGAAGTAGACAGAAACTTAATTCAGTATGTCCATTTGGGGCAAGAGGGCATTCGGGACCTAATTAAATTTGATGTG ACTGATGGAATAAATCCCCTCATAGATCGTTACTTTTATGTGTCCATCGGGAGCATTGACATTGTCTTCCCTGATGTGATAAGTAAGGGA GTGTCCTTGAAAGAAGGTGGCAAAGTCACTCTTACAACAGACCTACTAAGCACTAGTGACTTGAACAGTCCTGATGAAAACTTGGTTTTT ACCATCACCAGGGCTCCCATGCGAGGTCACCTGGAATGCACGGATCAGCCTGGTGTGTCCATCACGTCTTTCACTCAGCTGCAACTGGCT GGAAACAAAATCTACTACATCCACACAGCTGATGATGAAGTGAAAATGGACAGTTTTGAGTTTCAAGTCACCGATGGACGTAACCCTGTC TTTCGGACATTCCGTATCTCCATTAGCGATGTGGACAATAAAAAGCCAGTGGTCACCATCCACAAGCTGGTTGTCAGTGAAAGTGAAAAC AAGCTGATTACTCCTTTTGAGCTCACTGTCGAAGACAGAGATACTCCTGACAAGCTCCTGAAATTCACTATCACCCAGGTGCCTATTCAT GGCCATCTCCTATTCAACAATACCAGACCTGTCATGGTTTTTACCAAGCAAGACTTGAATGAAAACTTAATCAGCTACAAACATGATGGC ACTGAGTCAAGTGAAGATAGCTTCTCCTTCACAGTGACTGATGGCACCCATACAGACTTCTATGTTTTTCCTGATACGGTGTTTGAAACA AGGAGACCCCAAGTGATGAAGATCCAGGTCTTGGCTGTTGACAACAGTGTCCCCCAAATCGCAGTGAATAAGGGGGCCTCTACACTTCGC ACTCTAGCCACTGGCCACTTGGGGTTCATGATCACAAGCAAAATATTGAAAGTGGAGGACAGAGACAGCTTACACATTTCTCTTAGATTT ATCGTGACAGAGGCCCCTCAACATGGATATCTTCTCAACCTGGACAAAGGCAACCACAGCATCACTCAGTTCACACAAGCTGACATTGAT GACATGAAAATATGCTATGTCTTAAGAGAAGGGGCTAATGCCACAAGTGATATGTTCTATTTTGCAGTTGAAGATGGTGGTGGAAACAAG TTAACGTACCAGAATTTTCGTCTGAATTGGGCATGGATCTCCTTTGAAAAGGAATATTACCTGGTCAATGAGGACTCCAAATTTCTAGAT GTTGTTCTTAAACGTAGAGGTTACTTGGGAGAAACTTCTTTTATAAGTATTGGCACAAGAGACAGAACTGCAGAAAAAGACAAAGACTTC AAGGGCAAAGCACAGAAACAAGTGCAGTTCAACCCAGGCCAGACCAGGGCCACATGGCGAGTGCGGATCCTGAGTGATGGGGAGCATGAG CAGTCTGAAACCTTTCAGGTGGTACTCTCAGAGCCCGTGCTGGCTGCCTTGGAATTCCCCACAGTCGCCACTGTTGAGATCGTTGATCCA GGAGATGAGCCAACTGTGTTTATTCCCCAGTCCAAATACTCCGTTGAAGAAGATGTTGGTGAGCTGTTCATTCCCATCAGGAGGAGCGGA GATGTGAGCCAGGAGTTGATGGTGGTCTGTTATACCCAACAAGGAACAGCAACTGGAACTGTGCCGACTTCCGTGTTGTCTTACTCTGAT TACATATCCAGGCCTGAGGACCACACCAGTGTTGTCCGCTTTGACAAAGATGAACGGGAGAAACTGTGTCGGATAGTCATAATTGATGAC TCTTTGTACGAGGAGGAGGAAACCTTCCATGTCCTTCTGAGCATGCCCATGGGGGGAAGAATCGGATCAGAGTTCCCAGGGGCTCAAGTT ACAATCGTTCCTGACAAAGATGATGAACCCATCTTTTACTTCGGTGATGTGGAATACTCTGTGGATGAGAGTGCTGGCTATGTGGAAGTG CAGGTGTGGAGAACGGGCACTGACCTGTCCAAGTCTTCTAGTGTCACAGTGAGGTCTCGGAAAACAGATCCTCCCTCTGCAGATGCTGGA ACAGACTATGTGGGCATCAGCCGTAATTTAGATTTTGCACCTGGAGTCAACATGCAGCCTGTTCGTGTTGTCATTCTGGATGACCTTGGA CAACCAGCGCTGGAGGGAATTGAGAAATTTGAACTGGTGCTTCGCATGCCTATGAACGCAGCCCTTGGCGAGCCCAGCAAAGCCACAGTG TCCATAAATGACTCTGTCTCCGATTTGCCTAAGATGCAATTCAAAGAACGAATATATACTGGCAGCGAAAGTGATGGGCAGATAGTTACA ATGATCCATAGGACTGGGGATGTCCAGTACAGATCTTCAGTGAGATGCTACACCCGGCAGGGGTCTGCACAGGTGATGATGGACTTTGAA GAACGCCCAAACACTGATACCTCCATCATCACATTCCTCCCTGGTGAGACAGAAAAGCCCTGCATTCTTGAGCTGATGGACGATGTGCTC TATGAGGAGGTAGAGGAGCTCCGCCTGGTACTCGGCACTCCACAAAGCAACTCTCCCTTTGGGGCTGCAGTTGGTGAACAAAATGAAACT CTCATAAGGATCCGAGATGATGCTGATAAGACTGTTATTAAATTTGGAGAAACCAAATTTAGTGTCACTGAACCCAAAGAACCTGGAGAG TCGGTGGTTATAAGAATTCCAGTGATTCGCCAAGGAGACACTTCAAAGGTTTCCATTGTGAGAGTCCACACCAAGGATGGCTCGGCCACC TCTGGAGAAGACTACCACCCTGTGTCAGAAGAAATTGAGTTTAAGGAAGGGGAAACCCAGCACGTGGTTGAAATCGAAGTTACCTTTGAC GGGGTGAGAGAGATGAGAGAGGCCTTCACTGTTCACCTAAAACCTGATGAAAATATGATAGCAGAGATGCAGTTGACGAAAGCCATTGTG TACATAGAAGAAATGAGCAGCATGGCAGATGTCACTTTTCCTTCTGTCCCTCAAATTGTATCCCTGTTGATGTATGACGACACTTCCAAA GCTAAGGAGAGTGCTGAACCCATGTCTGGCTATCCTGTCATCTGTATCACAGCTTGCAACCCCAAATATTCAGACTACGATAAAACAGGC TCTATCTGTGCAAGTGAGAACATCAATGACACTTTGACGCGGTACCGGTGGCTGATTAGTGCACCTGCGGGCCCTGACGGTGTGACCAGC CCTATGAGAGAAGTGGACTTCGACACCTTTTTTACGTCATCCAAGATGGTCACACTGGACTCCATATACTTTCAGCCTGGCTCCCGGGTA CAGTGCGCAGCTCGTGCTGTGAACACCAATGGGGATGAAGGCCTGGAGCTCATGAGCCCTATTGTAACCATCAGCAGAGAAGAAGGTCTT TGTCAGCCCCGTGTACCTGGGGTTGTTGGAGCAGAGCCGTTCTCAGCTAAATTGCGCTACACAGGCCCTGAGGATGCAGACTACACAAAC CTTATCAAGCTCACTGTCACAATGCCACACATAGATGGCATGCTCCCCGTGATCTCCACTAGAGAGCTTTCCAACTTTGAGCTCACCCTC AGCCCTGATGGCACAAGAGTTGGAAACCACAAGTGCTCCAACCTCCTGGATTATACTGAAGTGAAGACTCATTATGGTTTCTTGACTGAT GCTACCAAAAATCCAGAAATAATTGGAGAGACATATCCTTACCAGTACAGCTTGTCCATCAGAGGTTCCACTACCTTGCGCTTCTACCGG AACCTGAACCTAGAGGCCTGTTTATGGGAGTTCGTTAGCTACTATGACATGTCAGAACTCCTTGCTGACTGTGGTGGCACCATTGGAACA GATGGACAGGTGGATGTGAAATTGGACCCCAAGGATTTGCGAATAGATACATTTCGAGCCAAAGGAGCAGGAGGGCAGCATGTTAATAAA ACTGATAGTGCCGTCAGACTTGTCCACATCCCCACAGGGCTAGTAGTAGAATGCCAACAAGAAAGATCACAGATAAAAAATAAAGAAATA GCCTTTCGTGTGTTGAGAGCTAGACTCTACCAGCAGATTATTGAGAAAGACAAGCGTCAGCAACAAAGTGCTAGAAAACTGCAGGTGGGA ACAAGAGCCCAGTCAGAGCGAATTCGGACATATAATTTCACCCAGGATAGAGTCAGTGACCACAGGATAGCATATGAAGTTCGTGATATT AAGGCTCAGTCTCATTCCACGGGTGGTAGTCGTGACCCTGCACATTCCACATTCCTATCCTTGGATTCTGTGAGATCACCTGGTATTCTC ATTATGACTTCTTCTGTTAGGAATTTTTATGTGGTGGGAAGGGCCTGGATCAGCTAATTCAGAGACTGCTTCAATCAGCAGATGAAGAAG >31294_31294_3_FREM2-MTRF1_FREM2_chr13_39438743_ENST00000280481_MTRF1_chr13_41808143_ENST00000430347_length(amino acids)=2888AA_BP=2723 MRLQPGRRRATLPSFWPSPGYRRTPRATRGVPGTSRRCLLLSARGPTSHALRLTCPSPNTGTMHSAGTPGLSSRRTGNSTSFQPGPPPPP RLLLLLLLLLSLVSRVPAQPAAFGRALLSPGLAGAAGVPAEEAIVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQR PGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFA FQPETEECRVGILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRSRGAPVGSPAL KREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDRSLPLSSFTQRDL RLLKIAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEA VRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNANTG LTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHS GPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTD TDENHLPAPLGTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTFTLYLHPVDNQPPEILNTGFT IQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRHHVVPIT LRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTH TSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVI QPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREF MVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSV EKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRN LIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGH LECTDQPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTV EDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQV LAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLRE GANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQF NPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVC YTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEP IFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKF ELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSII TFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIR QGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMAD VTFPSVPQIVSLLMYDDTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICASENINDTLTRYRWLISAPAGPDGVTSPMREVDFDTF FTSSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAEPFSAKLRYTGPEDADYTNLIKLTVTMPH IDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHYGFLTDATKNPEIIGETYPYQYSLSIRGSTTLRFYRNLNLEACLWE FVSYYDMSELLADCGGTIGTDGQVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLY QQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKAQSHSTGGSRDPAHSTFLSLDSVRSPGILIMTSSVRNFY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FREM2-MTRF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FREM2-MTRF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FREM2-MTRF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FREM2 | C4540036 | FRASER SYNDROME 2 | 3 | GENOMICS_ENGLAND;UNIPROT |
| Hgene | FREM2 | C0265233 | Cryptophthalmos syndrome | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Hgene | FREM2 | C0266294 | Unilateral agenesis of kidney | 2 | ORPHANET |
| Hgene | FREM2 | C1852453 | Cryptophthalmos, Unilateral or Bilateral, Isolated | 2 | ORPHANET;UNIPROT |
| Hgene | FREM2 | C4551480 | FRASER SYNDROME 1 | 2 | GENOMICS_ENGLAND |
| Hgene | FREM2 | C0015397 | Disorder of eye | 1 | GENOMICS_ENGLAND |
| Hgene | FREM2 | C0152423 | Congenital small ears | 1 | GENOMICS_ENGLAND |
| Hgene | FREM2 | C0152427 | Polydactyly | 1 | GENOMICS_ENGLAND |
| Hgene | FREM2 | C1855425 | Marles Greenberg Persaud syndrome | 1 | GENOMICS_ENGLAND |
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