Fusion gene information | Fusion gene name: IFNAR1-RPS27A |
Fusion gene ID: hg3454tg6233 | | Hgene | Tgene | Gene symbol | IFNAR1 | RPS27A | Gene ID | 3454 | 6233 | Gene name | interferon alpha and beta receptor subunit 1 | ribosomal protein S27a |
Synonyms | AVP|IFN-alpha-REC|IFNAR|IFNBR|IFRC | CEP80|HEL112|S27A|UBA80|UBC|UBCEP1|UBCEP80 |
Cytomap | ('IFNAR1')('RPS27A') 21q22.11 | 2p16.1 |
Type of gene | protein-coding | protein-coding |
Description | interferon alpha/beta receptor 1CRF2-1IFN-R-1IFN-alpha/beta receptor 1alpha-type antiviral proteinbeta-type antiviral proteincytokine receptor class-II member 1cytokine receptor family 2 member 1interferon (alpha, beta and omega) receptor 1interf | ubiquitin-40S ribosomal protein S27a40S ribosomal protein S27aepididymis luminal protein 112ubiquitin Cubiquitin and ribosomal protein S27aubiquitin carboxyl extension protein 80ubiquitin-CEP80 |
Modification date | 20200313 | 20200313 |
UniProtAcc | . | . |
Ensembl transtripts involved in fusion gene | ENST00000270139, ENST00000416947, ENST00000442357, ENST00000493503,
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Fusion gene scores | * DoF score | 7 X 8 X 4=224 | 12 X 13 X 6=936 |
# samples | 7 | 17 |
** MAII score | log2(7/224*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/936*10)=-2.4609737834457 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 |
Context | PubMed: IFNAR1 [Title/Abstract] AND RPS27A [Title/Abstract] AND fusion [Title/Abstract] |
Most frequent breakpoint | IFNAR1(34727789)-RPS27A(55460532), # samples:1
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Anticipated loss of major functional domain due to fusion event. | IFNAR1-RPS27A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. IFNAR1-RPS27A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
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Hgene | Tgene |
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FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |