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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APP-CYYR1 (FusionGDB2 ID:HG351TG116159)

Fusion Gene Summary for APP-CYYR1

check button Fusion gene summary
Fusion gene informationFusion gene name: APP-CYYR1
Fusion gene ID: hg351tg116159
HgeneTgene
Gene symbol

APP

CYYR1

Gene ID

351

116159

Gene nameamyloid beta precursor proteincysteine and tyrosine rich 1
SynonymsAAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4C21orf95
Cytomap('APP')('CYYR1')

21q21.3

21q21.3

Type of geneprotein-codingprotein-coding
Descriptionamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor proteicysteine and tyrosine-rich protein 1cysteine and tyrosine-rich protein 1 isoform 1,2,2bis,3,4cysteine and tyrosine-rich protein 1 isoform 1,2,3,4bcysteine and tyrosine-rich protein 1 isoform 1,2,3bcysteine and tyrosine-rich protein 1 isoform 1,2,4cys
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000346798, ENST00000348990, 
ENST00000357903, ENST00000358918, 
ENST00000359726, ENST00000440126, 
ENST00000448388, ENST00000474136, 
ENST00000354192, ENST00000439274, 
ENST00000440126, ENST00000448388, 
ENST00000474136, ENST00000348990, 
ENST00000354192, ENST00000357903, 
ENST00000358918, ENST00000359726, 
ENST00000439274, ENST00000346798, 
Fusion gene scores* DoF score31 X 25 X 12=93004 X 4 X 3=48
# samples 335
** MAII scorelog2(33/9300*10)=-4.81669278663694
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: APP [Title/Abstract] AND CYYR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPP(27462259)-CYYR1(27938687), # samples:1
APP(27484296)-CYYR1(27852748), # samples:1
Anticipated loss of major functional domain due to fusion event.APP-CYYR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-CYYR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-CYYR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-CYYR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CYYR1-APP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYYR1-APP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

HgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

HgeneAPP

GO:1905606

regulation of presynapse assembly

19726636


check buttonFusion gene breakpoints across APP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CYYR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A6VV-01AAPPchr21

27462259

-CYYR1chr21

27938687

-
ChimerDB4BRCATCGA-A7-A6VV-01AAPPchr21

27484296

-CYYR1chr21

27852748

-


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Fusion Gene ORF analysis for APP-CYYR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000346798ENST00000400043APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000346798ENST00000435845APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000348990ENST00000400043APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000348990ENST00000435845APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000357903ENST00000400043APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000357903ENST00000435845APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000358918ENST00000400043APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000358918ENST00000435845APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000359726ENST00000400043APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000359726ENST00000435845APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000440126ENST00000400043APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000440126ENST00000435845APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000448388ENST00000400043APPchr21

27484296

-CYYR1chr21

27852748

-
5CDS-3UTRENST00000448388ENST00000435845APPchr21

27484296

-CYYR1chr21

27852748

-
5UTR-3CDSENST00000474136ENST00000299340APPchr21

27462259

-CYYR1chr21

27938687

-
5UTR-3CDSENST00000474136ENST00000299340APPchr21

27484296

-CYYR1chr21

27852748

-
5UTR-3CDSENST00000474136ENST00000400043APPchr21

27462259

-CYYR1chr21

27938687

-
5UTR-3CDSENST00000474136ENST00000435845APPchr21

27462259

-CYYR1chr21

27938687

-
5UTR-3UTRENST00000474136ENST00000400043APPchr21

27484296

-CYYR1chr21

27852748

-
5UTR-3UTRENST00000474136ENST00000435845APPchr21

27484296

-CYYR1chr21

27852748

-
Frame-shiftENST00000346798ENST00000299340APPchr21

27484296

-CYYR1chr21

27852748

-
Frame-shiftENST00000346798ENST00000435845APPchr21

27462259

-CYYR1chr21

27938687

-
Frame-shiftENST00000348990ENST00000299340APPchr21

27484296

-CYYR1chr21

27852748

-
Frame-shiftENST00000348990ENST00000435845APPchr21

27462259

-CYYR1chr21

27938687

-
Frame-shiftENST00000354192ENST00000435845APPchr21

27462259

-CYYR1chr21

27938687

-
Frame-shiftENST00000357903ENST00000299340APPchr21

27484296

-CYYR1chr21

27852748

-
Frame-shiftENST00000357903ENST00000435845APPchr21

27462259

-CYYR1chr21

27938687

-
Frame-shiftENST00000358918ENST00000299340APPchr21

27484296

-CYYR1chr21

27852748

-
Frame-shiftENST00000358918ENST00000435845APPchr21

27462259

-CYYR1chr21

27938687

-
Frame-shiftENST00000359726ENST00000299340APPchr21

27484296

-CYYR1chr21

27852748

-
Frame-shiftENST00000359726ENST00000435845APPchr21

27462259

-CYYR1chr21

27938687

-
Frame-shiftENST00000439274ENST00000435845APPchr21

27462259

-CYYR1chr21

27938687

-
Frame-shiftENST00000440126ENST00000299340APPchr21

27484296

-CYYR1chr21

27852748

-
Frame-shiftENST00000440126ENST00000435845APPchr21

27462259

-CYYR1chr21

27938687

-
Frame-shiftENST00000448388ENST00000299340APPchr21

27484296

-CYYR1chr21

27852748

-
Frame-shiftENST00000448388ENST00000435845APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000346798ENST00000299340APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000346798ENST00000400043APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000348990ENST00000299340APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000348990ENST00000400043APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000354192ENST00000299340APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000354192ENST00000400043APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000357903ENST00000299340APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000357903ENST00000400043APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000358918ENST00000299340APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000358918ENST00000400043APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000359726ENST00000299340APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000359726ENST00000400043APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000439274ENST00000299340APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000439274ENST00000400043APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000440126ENST00000299340APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000440126ENST00000400043APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000448388ENST00000299340APPchr21

27462259

-CYYR1chr21

27938687

-
In-frameENST00000448388ENST00000400043APPchr21

27462259

-CYYR1chr21

27938687

-
intron-3CDSENST00000354192ENST00000299340APPchr21

27484296

-CYYR1chr21

27852748

-
intron-3CDSENST00000439274ENST00000299340APPchr21

27484296

-CYYR1chr21

27852748

-
intron-3UTRENST00000354192ENST00000400043APPchr21

27484296

-CYYR1chr21

27852748

-
intron-3UTRENST00000354192ENST00000435845APPchr21

27484296

-CYYR1chr21

27852748

-
intron-3UTRENST00000439274ENST00000400043APPchr21

27484296

-CYYR1chr21

27852748

-
intron-3UTRENST00000439274ENST00000435845APPchr21

27484296

-CYYR1chr21

27852748

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346798APPchr2127462259-ENST00000299340CYYR1chr2127938687-307338934780248
ENST00000346798APPchr2127462259-ENST00000400043CYYR1chr2127938687-81538934714226
ENST00000354192APPchr2127462259-ENST00000299340CYYR1chr2127938687-2998314127705192
ENST00000354192APPchr2127462259-ENST00000400043CYYR1chr2127938687-740314127639170
ENST00000348990APPchr2127462259-ENST00000299340CYYR1chr2127938687-3186502147893248
ENST00000348990APPchr2127462259-ENST00000400043CYYR1chr2127938687-928502147827226
ENST00000357903APPchr2127462259-ENST00000299340CYYR1chr2127938687-3206522167913248
ENST00000357903APPchr2127462259-ENST00000400043CYYR1chr2127938687-948522167847226
ENST00000358918APPchr2127462259-ENST00000299340CYYR1chr2127938687-3239555200946248
ENST00000358918APPchr2127462259-ENST00000400043CYYR1chr2127938687-981555200880226
ENST00000359726APPchr2127462259-ENST00000299340CYYR1chr2127938687-3239555200946248
ENST00000359726APPchr2127462259-ENST00000400043CYYR1chr2127938687-981555200880226
ENST00000448388APPchr2127462259-ENST00000299340CYYR1chr2127938687-3126442168833221
ENST00000448388APPchr2127462259-ENST00000400043CYYR1chr2127938687-868442168767199
ENST00000440126APPchr2127462259-ENST00000299340CYYR1chr2127938687-3290606239997252
ENST00000440126APPchr2127462259-ENST00000400043CYYR1chr2127938687-1032606239931230
ENST00000439274APPchr2127462259-ENST00000299340CYYR1chr2127938687-290522134612192
ENST00000439274APPchr2127462259-ENST00000400043CYYR1chr2127938687-64722134546170

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346798ENST00000299340APPchr2127462259-CYYR1chr2127938687-0.0007432970.9992567
ENST00000346798ENST00000400043APPchr2127462259-CYYR1chr2127938687-0.0006672340.9993327
ENST00000354192ENST00000299340APPchr2127462259-CYYR1chr2127938687-0.0010031870.9989968
ENST00000354192ENST00000400043APPchr2127462259-CYYR1chr2127938687-0.0019269630.998073
ENST00000348990ENST00000299340APPchr2127462259-CYYR1chr2127938687-0.0008580610.99914193
ENST00000348990ENST00000400043APPchr2127462259-CYYR1chr2127938687-0.0008101460.9991898
ENST00000357903ENST00000299340APPchr2127462259-CYYR1chr2127938687-0.0008846060.9991154
ENST00000357903ENST00000400043APPchr2127462259-CYYR1chr2127938687-0.0009032870.99909675
ENST00000358918ENST00000299340APPchr2127462259-CYYR1chr2127938687-0.0009537950.99904615
ENST00000358918ENST00000400043APPchr2127462259-CYYR1chr2127938687-0.0008163720.9991836
ENST00000359726ENST00000299340APPchr2127462259-CYYR1chr2127938687-0.0009537950.99904615
ENST00000359726ENST00000400043APPchr2127462259-CYYR1chr2127938687-0.0008163720.9991836
ENST00000448388ENST00000299340APPchr2127462259-CYYR1chr2127938687-0.0012051120.9987949
ENST00000448388ENST00000400043APPchr2127462259-CYYR1chr2127938687-0.0005661490.9994338
ENST00000440126ENST00000299340APPchr2127462259-CYYR1chr2127938687-0.0009239470.999076
ENST00000440126ENST00000400043APPchr2127462259-CYYR1chr2127938687-0.0012817990.99871826
ENST00000439274ENST00000299340APPchr2127462259-CYYR1chr2127938687-0.0012593750.9987406
ENST00000439274ENST00000400043APPchr2127462259-CYYR1chr2127938687-0.0014707160.9985293

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Fusion Genomic Features for APP-CYYR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for APP-CYYR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:27462259/chr21:27938687)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-31896_110118771.0RegionHeparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-31696_110118696.0RegionHeparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-31796_110118752.0RegionHeparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-31796_110118753.0RegionHeparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-31796_110118715.0RegionHeparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-31796_110113747.0RegionHeparin-binding
TgeneCYYR1chr21:27462259chr21:27938687ENST0000029934004144_14924155.0Compositional biasNote=Poly-Pro
TgeneCYYR1chr21:27462259chr21:27938687ENST000002993400430_6124155.0Topological domainExtracellular
TgeneCYYR1chr21:27462259chr21:27938687ENST000002993400483_15424155.0Topological domainCytoplasmic
TgeneCYYR1chr21:27462259chr21:27938687ENST000002993400462_8224155.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318230_260118771.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318274_280118771.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316230_260118696.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316274_280118696.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215230_26062640.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215274_28062640.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317230_260118752.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317274_280118752.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317230_260118753.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317274_280118753.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317230_260118715.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317274_280118715.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317230_260113747.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317274_280113747.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-31828_189118771.0DomainE1
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318374_565118771.0DomainE2
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-31628_189118696.0DomainE1
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316374_565118696.0DomainE2
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-21528_18962640.0DomainE1
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215374_56562640.0DomainE2
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-31728_189118752.0DomainE1
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317374_565118752.0DomainE2
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-31728_189118753.0DomainE1
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317374_565118753.0DomainE2
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-31728_189118715.0DomainE1
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317374_565118715.0DomainE2
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-31728_189113747.0DomainE1
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317374_565113747.0DomainE2
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318344_365118771.0MotifOX-2
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318724_734118771.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316344_365118696.0MotifOX-2
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316724_734118696.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215344_36562640.0MotifOX-2
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215724_73462640.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317344_365118752.0MotifOX-2
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317724_734118752.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317344_365118753.0MotifOX-2
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317724_734118753.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317344_365118715.0MotifOX-2
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317724_734118715.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317344_365113747.0MotifOX-2
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317724_734113747.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318131_189118771.0RegionCuBD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318181_188118771.0RegionNote=Zinc-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-31828_123118771.0RegionGFLD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318391_423118771.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318491_522118771.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318523_540118771.0RegionCollagen-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316131_189118696.0RegionCuBD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316181_188118696.0RegionNote=Zinc-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-31628_123118696.0RegionGFLD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316391_423118696.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316491_522118696.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316523_540118696.0RegionCollagen-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215131_18962640.0RegionCuBD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215181_18862640.0RegionNote=Zinc-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-21528_12362640.0RegionGFLD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215391_42362640.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215491_52262640.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215523_54062640.0RegionCollagen-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-21596_11062640.0RegionHeparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317131_189118752.0RegionCuBD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317181_188118752.0RegionNote=Zinc-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-31728_123118752.0RegionGFLD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317391_423118752.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317491_522118752.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317523_540118752.0RegionCollagen-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317131_189118753.0RegionCuBD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317181_188118753.0RegionNote=Zinc-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-31728_123118753.0RegionGFLD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317391_423118753.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317491_522118753.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317523_540118753.0RegionCollagen-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317131_189118715.0RegionCuBD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317181_188118715.0RegionNote=Zinc-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-31728_123118715.0RegionGFLD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317391_423118715.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317491_522118715.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317523_540118715.0RegionCollagen-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317131_189113747.0RegionCuBD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317181_188113747.0RegionNote=Zinc-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-31728_123113747.0RegionGFLD subdomain
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317391_423113747.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317491_522113747.0RegionNote=Heparin-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317523_540113747.0RegionCollagen-binding
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-31818_701118771.0Topological domainExtracellular
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318723_770118771.0Topological domainCytoplasmic
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-31618_701118696.0Topological domainExtracellular
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316723_770118696.0Topological domainCytoplasmic
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-21518_70162640.0Topological domainExtracellular
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215723_77062640.0Topological domainCytoplasmic
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-31718_701118752.0Topological domainExtracellular
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317723_770118752.0Topological domainCytoplasmic
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-31718_701118753.0Topological domainExtracellular
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317723_770118753.0Topological domainCytoplasmic
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-31718_701118715.0Topological domainExtracellular
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317723_770118715.0Topological domainCytoplasmic
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-31718_701113747.0Topological domainExtracellular
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317723_770113747.0Topological domainCytoplasmic
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318702_722118771.0TransmembraneHelical
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316702_722118696.0TransmembraneHelical
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215702_72262640.0TransmembraneHelical
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317702_722118752.0TransmembraneHelical
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317702_722118753.0TransmembraneHelical
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317702_722118715.0TransmembraneHelical
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317702_722113747.0TransmembraneHelical


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Fusion Gene Sequence for APP-CYYR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5668_5668_1_APP-CYYR1_APP_chr21_27462259_ENST00000346798_CYYR1_chr21_27938687_ENST00000299340_length(transcript)=3073nt_BP=389nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA
ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC
CCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTGTGATGGAACCACGCC
CTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGG
GGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAGGACGACTCACATCAA
CACCGTCTCCTCCTATCCTGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCTCCTCCATACTCCCCCAC
CCCACAGGGTCCAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAGAACAGAACATGTGCCAA
TGGGCGATCTTGCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTTTTGGGGTCAGATAATGT
GTCAGGTGGAATATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTAATGTTTGGTTCTATGGA
ACCACATTTTAAGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTGATAATCATGTTGTTTAA
GGGCTAGGTGAAGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTGGCCCACACAAGGAAGCA
ACTTTATTCTATATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTGAGTGCCTAAGAGTTTAC
TATGTGCCTAGCACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAGCAATGACTAGATTGCTT
TGTGAAGCTCTTGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTCAGAAGTTCTGCTCGTAT
TTTAGGTGGGTGTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATTTAATTAGGGAGTTAAAA
CAAGACCAAAAAGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCATCTGGCTTTATAGTGGA
TCAGAATAAAGGTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTCACTTCCAAGTAAAAGAT
GAGAAATCAATTATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACAACAGACTCGCAAAAATA
AAGTGGGAAATGAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAATTTTGATAATCTGTTCTC
TTAAAAAAGTTAATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGAAGTGCCTACCTTTATAT
GTATAAAGCATTTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTATATGAATTGTTTCATGTA
TTTATAAAAATTGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAAATGCTTAATCCAATATC
ATCATCAAAATTCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTTTAAGGTGTAAGTTATAG
TACCTGTACTTGCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATATTAGAAAGATATTGATC
TGACTGAAATATAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTAAGCACTGATGATTTTCT
TATATATGAGGATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTTTTCAGTGCAATTTTAAT
AGTACATATGCTTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAAGTGCCAGGGTTTCTGTG
ATGATTCTGAGAATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAAATAGGGTTTTCTCATCT
TCACCATCAATAAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTCCACACCATCTCTTCTTT
GAGTTGTTTATGGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTTGTATTAAGTGTCATAAT
AGCATCAATGTGCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGGGAAAAATAGTATAGGAT
GTGAAAGTTTTGAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAGTGTTTACAATAAGCAATAAAGTGAAAGAACCTATTAT

>5668_5668_1_APP-CYYR1_APP_chr21_27462259_ENST00000346798_CYYR1_chr21_27938687_ENST00000299340_length(amino acids)=248AA_BP=118
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICM

--------------------------------------------------------------
>5668_5668_2_APP-CYYR1_APP_chr21_27462259_ENST00000346798_CYYR1_chr21_27938687_ENST00000400043_length(transcript)=815nt_BP=389nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA
ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC
CCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTGTGATGGAACCACGCC
CTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGG
GGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAGGACGACTCACATCAA
CACCGTCTCCTCCTATCCTGAATATGAACTCCATGAGGCAGAGATCTTGGTCTATTTTGTTCAACACTCTATTCCAAGCATGTAAGACCA
GGCCTGGTACATAATGGGCACTCAGCTGAATGAATGATGAACACAACTCATGAAAAGACCTGAATTAATCATATATCAATACCCTAGGGA

>5668_5668_2_APP-CYYR1_APP_chr21_27462259_ENST00000346798_CYYR1_chr21_27938687_ENST00000400043_length(amino acids)=226AA_BP=118
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICM

--------------------------------------------------------------
>5668_5668_3_APP-CYYR1_APP_chr21_27462259_ENST00000348990_CYYR1_chr21_27938687_ENST00000299340_length(transcript)=3186nt_BP=502nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC
CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCT
TACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTT
TTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGC
ATCCTCAGGACGACTCACATCAACACCGTCTCCTCCTATCCTGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGAC
TTGCCTCCTCCATACTCCCCCACCCCACAGGGTCCAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATC
TCCCAGAACAGAACATGTGCCAATGGGCGATCTTGCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAA
TACTTTTTGGGGTCAGATAATGTGTCAGGTGGAATATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGA
GTATTAATGTTTGGTTCTATGGAACCACATTTTAAGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAA
TATCTGATAATCATGTTGTTTAAGGGCTAGGTGAAGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAAT
GATTTGGCCCACACAAGGAAGCAACTTTATTCTATATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGT
ATTTTGAGTGCCTAAGAGTTTACTATGTGCCTAGCACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAG
AAAGAGCAATGACTAGATTGCTTTGTGAAGCTCTTGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTG
GGCCTCAGAAGTTCTGCTCGTATTTTAGGTGGGTGTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTA
TTTATTTAATTAGGGAGTTAAAACAAGACCAAAAAGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAA
AAATCATCTGGCTTTATAGTGGATCAGAATAAAGGTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGA
CACTTCACTTCCAAGTAAAAGATGAGAAATCAATTATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGA
TACACAACAGACTCGCAAAAATAAAGTGGGAAATGAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCG
TAAAATTTTGATAATCTGTTCTCTTAAAAAAGTTAATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATT
TTATGAAGTGCCTACCTTTATATGTATAAAGCATTTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATAT
TTTTATATGAATTGTTTCATGTATTTATAAAAATTGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAA
TCTAAAATGCTTAATCCAATATCATCATCAAAATTCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAA
GCATTTTAAGGTGTAAGTTATAGTACCTGTACTTGCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATA
CCTATATTAGAAAGATATTGATCTGACTGAAATATAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGA
TCTTTAAGCACTGATGATTTTCTTATATATGAGGATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACAT
AAAGTTTTCAGTGCAATTTTAATAGTACATATGCTTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACT
CTCAAAGTGCCAGGGTTTCTGTGATGATTCTGAGAATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCA
GCAGAAATAGGGTTTTCTCATCTTCACCATCAATAAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGT
TCAGTCCACACCATCTCTTCTTTGAGTTGTTTATGGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTA
CTATTTGTATTAAGTGTCATAATAGCATCAATGTGCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTT
CTTGGGGAAAAATAGTATAGGATGTGAAAGTTTTGAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAGTGTTTACAATAAGC

>5668_5668_3_APP-CYYR1_APP_chr21_27462259_ENST00000348990_CYYR1_chr21_27938687_ENST00000299340_length(amino acids)=248AA_BP=118
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICM

--------------------------------------------------------------
>5668_5668_4_APP-CYYR1_APP_chr21_27462259_ENST00000348990_CYYR1_chr21_27938687_ENST00000400043_length(transcript)=928nt_BP=502nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC
CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCT
TACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTT
TTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGC
ATCCTCAGGACGACTCACATCAACACCGTCTCCTCCTATCCTGAATATGAACTCCATGAGGCAGAGATCTTGGTCTATTTTGTTCAACAC
TCTATTCCAAGCATGTAAGACCAGGCCTGGTACATAATGGGCACTCAGCTGAATGAATGATGAACACAACTCATGAAAAGACCTGAATTA

>5668_5668_4_APP-CYYR1_APP_chr21_27462259_ENST00000348990_CYYR1_chr21_27938687_ENST00000400043_length(amino acids)=226AA_BP=118
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICM

--------------------------------------------------------------
>5668_5668_5_APP-CYYR1_APP_chr21_27462259_ENST00000354192_CYYR1_chr21_27938687_ENST00000299340_length(transcript)=2998nt_BP=314nt
GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC
GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT
GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA
GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTG
TGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAAT
AGTATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAG
GACGACTCACATCAACACCGTCTCCTCCTATCCTGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCTCC
TCCATACTCCCCCACCCCACAGGGTCCAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAGAA
CAGAACATGTGCCAATGGGCGATCTTGCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTTTT
GGGGTCAGATAATGTGTCAGGTGGAATATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTAAT
GTTTGGTTCTATGGAACCACATTTTAAGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTGAT
AATCATGTTGTTTAAGGGCTAGGTGAAGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTGGC
CCACACAAGGAAGCAACTTTATTCTATATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTGAG
TGCCTAAGAGTTTACTATGTGCCTAGCACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAGCA
ATGACTAGATTGCTTTGTGAAGCTCTTGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTCAG
AAGTTCTGCTCGTATTTTAGGTGGGTGTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATTTA
ATTAGGGAGTTAAAACAAGACCAAAAAGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCATC
TGGCTTTATAGTGGATCAGAATAAAGGTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTCAC
TTCCAAGTAAAAGATGAGAAATCAATTATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACAAC
AGACTCGCAAAAATAAAGTGGGAAATGAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAATTT
TGATAATCTGTTCTCTTAAAAAAGTTAATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGAAG
TGCCTACCTTTATATGTATAAAGCATTTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTATAT
GAATTGTTTCATGTATTTATAAAAATTGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAAAT
GCTTAATCCAATATCATCATCAAAATTCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTTTA
AGGTGTAAGTTATAGTACCTGTACTTGCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATATT
AGAAAGATATTGATCTGACTGAAATATAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTAAG
CACTGATGATTTTCTTATATATGAGGATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTTTT
CAGTGCAATTTTAATAGTACATATGCTTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAAGT
GCCAGGGTTTCTGTGATGATTCTGAGAATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAAAT
AGGGTTTTCTCATCTTCACCATCAATAAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTCCA
CACCATCTCTTCTTTGAGTTGTTTATGGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTTGT
ATTAAGTGTCATAATAGCATCAATGTGCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGGGA
AAAATAGTATAGGATGTGAAAGTTTTGAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAGTGTTTACAATAAGCAATAAAGT

>5668_5668_5_APP-CYYR1_APP_chr21_27462259_ENST00000354192_CYYR1_chr21_27938687_ENST00000299340_length(amino acids)=192AA_BP=62
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYA
YIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNHRATRVGILRTTHINTVSSYPGPPPYGHDHEMEYCADLPPPYSPTPQGPAQR

--------------------------------------------------------------
>5668_5668_6_APP-CYYR1_APP_chr21_27462259_ENST00000354192_CYYR1_chr21_27938687_ENST00000400043_length(transcript)=740nt_BP=314nt
GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC
GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT
GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA
GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTG
TGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAAT
AGTATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAG
GACGACTCACATCAACACCGTCTCCTCCTATCCTGAATATGAACTCCATGAGGCAGAGATCTTGGTCTATTTTGTTCAACACTCTATTCC
AAGCATGTAAGACCAGGCCTGGTACATAATGGGCACTCAGCTGAATGAATGATGAACACAACTCATGAAAAGACCTGAATTAATCATATA

>5668_5668_6_APP-CYYR1_APP_chr21_27462259_ENST00000354192_CYYR1_chr21_27938687_ENST00000400043_length(amino acids)=170AA_BP=62
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYA

--------------------------------------------------------------
>5668_5668_7_APP-CYYR1_APP_chr21_27462259_ENST00000357903_CYYR1_chr21_27938687_ENST00000299340_length(transcript)=3206nt_BP=522nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC
AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGT
GTGGCAAAGATTGCAAATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCA
CTGCAATTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACC
ACAGGGCGACCCGCGTGGGCATCCTCAGGACGACTCACATCAACACCGTCTCCTCCTATCCTGGACCACCACCCTACGGTCACGACCACG
AGATGGAATACTGTGCAGACTTGCCTCCTCCATACTCCCCCACCCCACAGGGTCCAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAA
ACGCAAGGAAATAATCTATCTCCCAGAACAGAACATGTGCCAATGGGCGATCTTGCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAG
GAAAGAATTGCTCCAAGGAATACTTTTTGGGGTCAGATAATGTGTCAGGTGGAATATCCCTGCTAGGAGATATAGGATTTCTACTCTGCT
CAAAGCTGACCCCATCTGGAGTATTAATGTTTGGTTCTATGGAACCACATTTTAAGAGATCTGCTGATCCACCTAAGCACATTCAGGGAA
GAGTAATGTAATTGACAAAATATCTGATAATCATGTTGTTTAAGGGCTAGGTGAAGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGA
TCTAAGTAGGATGGGAGAATGATTTGGCCCACACAAGGAAGCAACTTTATTCTATATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTC
TTTCATTCATCAATAAATGTATTTTGAGTGCCTAAGAGTTTACTATGTGCCTAGCACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGG
TACTCTGGTTTTAGTACAAGAAAGAGCAATGACTAGATTGCTTTGTGAAGCTCTTGGTAGAGACACGCTCCAGAAGGGATAACAAAATCA
AATAGTAGATGGGTTCATTGGGCCTCAGAAGTTCTGCTCGTATTTTAGGTGGGTGTGAAGTGAATTTCTATATGTCCAGGAGTGAATACA
ACAGAAAGAGTTGGATCTTATTTATTTAATTAGGGAGTTAAAACAAGACCAAAAAGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAA
TGCCAGCTACTGCCACCTAAAAATCATCTGGCTTTATAGTGGATCAGAATAAAGGTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTAT
CAAGTTCCACAGGTAGCAGACACTTCACTTCCAAGTAAAAGATGAGAAATCAATTATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATC
TCAGAACTTGACCATGAAGATACACAACAGACTCGCAAAAATAAAGTGGGAAATGAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAAC
TATTATTTTTTTCTTCTTCGTAAAATTTTGATAATCTGTTCTCTTAAAAAAGTTAATGACACAATTAAGATACTGACATCAAATTGTTGC
CTTTTACCAAAATGCAAATTTTATGAAGTGCCTACCTTTATATGTATAAAGCATTTAATAAATAATTCTAATGTGCCATATTTTGCTGTG
AGTGACCTTAACATTTATATTTTTATATGAATTGTTTCATGTATTTATAAAAATTGTATATTGAACATTGGAAATAGATGATTAGATTTT
TGTGTCATTTTACAATTAAATCTAAAATGCTTAATCCAATATCATCATCAAAATTCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCT
GAATGAAACAATCAAACAAAGCATTTTAAGGTGTAAGTTATAGTACCTGTACTTGCAGATAAGAAGCTTACTATATCATTATTATAAGTA
GCATATATTACTTTCAAATACCTATATTAGAAAGATATTGATCTGACTGAAATATAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTT
GTTTTGAATGAGTTCCTTGATCTTTAAGCACTGATGATTTTCTTATATATGAGGATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTG
AGGGGCTCCCTGACTTACATAAAGTTTTCAGTGCAATTTTAATAGTACATATGCTTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCA
ATTACACTGTGGCTAAGACTCTCAAAGTGCCAGGGTTTCTGTGATGATTCTGAGAATGCTGAATACAAATATACCTTATATTCTTTAAGG
AAAACGGAAAGGAAAGATCAGCAGAAATAGGGTTTTCTCATCTTCACCATCAATAAACATTTATTGCGTACCTCCTATATTCTGCAAATT
TTCCCCAAATAGAAGCCAGTTCAGTCCACACCATCTCTTCTTTGAGTTGTTTATGGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCT
ACAATAGATGAGTATTTTTACTATTTGTATTAAGTGTCATAATAGCATCAATGTGCACATTACCAGTATAGACTGTTGGAGTTCACTGAT
TGTTTTCATAGATGATGCTTCTTGGGGAAAAATAGTATAGGATGTGAAAGTTTTGAATTACGGTTATTTAAAAACTAACATTTGCTATGG

>5668_5668_7_APP-CYYR1_APP_chr21_27462259_ENST00000357903_CYYR1_chr21_27938687_ENST00000299340_length(amino acids)=248AA_BP=118
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICM

--------------------------------------------------------------
>5668_5668_8_APP-CYYR1_APP_chr21_27462259_ENST00000357903_CYYR1_chr21_27938687_ENST00000400043_length(transcript)=948nt_BP=522nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC
AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGT
GTGGCAAAGATTGCAAATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCA
CTGCAATTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACC
ACAGGGCGACCCGCGTGGGCATCCTCAGGACGACTCACATCAACACCGTCTCCTCCTATCCTGAATATGAACTCCATGAGGCAGAGATCT
TGGTCTATTTTGTTCAACACTCTATTCCAAGCATGTAAGACCAGGCCTGGTACATAATGGGCACTCAGCTGAATGAATGATGAACACAAC

>5668_5668_8_APP-CYYR1_APP_chr21_27462259_ENST00000357903_CYYR1_chr21_27938687_ENST00000400043_length(amino acids)=226AA_BP=118
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICM

--------------------------------------------------------------
>5668_5668_9_APP-CYYR1_APP_chr21_27462259_ENST00000358918_CYYR1_chr21_27938687_ENST00000299340_length(transcript)=3239nt_BP=555nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCT
ACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGA
TTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAGGACGACTCACATCAACACCGTCTCCTCCT
ATCCTGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCTCCTCCATACTCCCCCACCCCACAGGGTCCAG
CACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAGAACAGAACATGTGCCAATGGGCGATCTTGCC
TGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTTTTGGGGTCAGATAATGTGTCAGGTGGAATAT
CCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTAATGTTTGGTTCTATGGAACCACATTTTAAGA
GATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTGATAATCATGTTGTTTAAGGGCTAGGTGAAGA
AAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTGGCCCACACAAGGAAGCAACTTTATTCTATAT
AGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTGAGTGCCTAAGAGTTTACTATGTGCCTAGCAC
TGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAGCAATGACTAGATTGCTTTGTGAAGCTCTTGG
TAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTCAGAAGTTCTGCTCGTATTTTAGGTGGGTGTG
AAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATTTAATTAGGGAGTTAAAACAAGACCAAAAAGA
CTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCATCTGGCTTTATAGTGGATCAGAATAAAGGTT
ATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTCACTTCCAAGTAAAAGATGAGAAATCAATTAT
TCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACAACAGACTCGCAAAAATAAAGTGGGAAATGAA
GTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAATTTTGATAATCTGTTCTCTTAAAAAAGTTAAT
GACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGAAGTGCCTACCTTTATATGTATAAAGCATTTA
ATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTATATGAATTGTTTCATGTATTTATAAAAATTGT
ATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAAATGCTTAATCCAATATCATCATCAAAATTCA
GTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTTTAAGGTGTAAGTTATAGTACCTGTACTTGCA
GATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATATTAGAAAGATATTGATCTGACTGAAATATAA
CCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTAAGCACTGATGATTTTCTTATATATGAGGATG
CAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTTTTCAGTGCAATTTTAATAGTACATATGCTTT
AATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAAGTGCCAGGGTTTCTGTGATGATTCTGAGAAT
GCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAAATAGGGTTTTCTCATCTTCACCATCAATAAA
CATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTCCACACCATCTCTTCTTTGAGTTGTTTATGGC
CTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTTGTATTAAGTGTCATAATAGCATCAATGTGCA
CATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGGGAAAAATAGTATAGGATGTGAAAGTTTTGAA

>5668_5668_9_APP-CYYR1_APP_chr21_27462259_ENST00000358918_CYYR1_chr21_27938687_ENST00000299340_length(amino acids)=248AA_BP=118
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICM

--------------------------------------------------------------
>5668_5668_10_APP-CYYR1_APP_chr21_27462259_ENST00000358918_CYYR1_chr21_27938687_ENST00000400043_length(transcript)=981nt_BP=555nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCT
ACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGA
TTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAGGACGACTCACATCAACACCGTCTCCTCCT
ATCCTGAATATGAACTCCATGAGGCAGAGATCTTGGTCTATTTTGTTCAACACTCTATTCCAAGCATGTAAGACCAGGCCTGGTACATAA

>5668_5668_10_APP-CYYR1_APP_chr21_27462259_ENST00000358918_CYYR1_chr21_27938687_ENST00000400043_length(amino acids)=226AA_BP=118
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICM

--------------------------------------------------------------
>5668_5668_11_APP-CYYR1_APP_chr21_27462259_ENST00000359726_CYYR1_chr21_27938687_ENST00000299340_length(transcript)=3239nt_BP=555nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCT
ACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGA
TTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAGGACGACTCACATCAACACCGTCTCCTCCT
ATCCTGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCTCCTCCATACTCCCCCACCCCACAGGGTCCAG
CACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAGAACAGAACATGTGCCAATGGGCGATCTTGCC
TGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTTTTGGGGTCAGATAATGTGTCAGGTGGAATAT
CCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTAATGTTTGGTTCTATGGAACCACATTTTAAGA
GATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTGATAATCATGTTGTTTAAGGGCTAGGTGAAGA
AAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTGGCCCACACAAGGAAGCAACTTTATTCTATAT
AGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTGAGTGCCTAAGAGTTTACTATGTGCCTAGCAC
TGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAGCAATGACTAGATTGCTTTGTGAAGCTCTTGG
TAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTCAGAAGTTCTGCTCGTATTTTAGGTGGGTGTG
AAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATTTAATTAGGGAGTTAAAACAAGACCAAAAAGA
CTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCATCTGGCTTTATAGTGGATCAGAATAAAGGTT
ATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTCACTTCCAAGTAAAAGATGAGAAATCAATTAT
TCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACAACAGACTCGCAAAAATAAAGTGGGAAATGAA
GTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAATTTTGATAATCTGTTCTCTTAAAAAAGTTAAT
GACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGAAGTGCCTACCTTTATATGTATAAAGCATTTA
ATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTATATGAATTGTTTCATGTATTTATAAAAATTGT
ATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAAATGCTTAATCCAATATCATCATCAAAATTCA
GTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTTTAAGGTGTAAGTTATAGTACCTGTACTTGCA
GATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATATTAGAAAGATATTGATCTGACTGAAATATAA
CCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTAAGCACTGATGATTTTCTTATATATGAGGATG
CAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTTTTCAGTGCAATTTTAATAGTACATATGCTTT
AATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAAGTGCCAGGGTTTCTGTGATGATTCTGAGAAT
GCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAAATAGGGTTTTCTCATCTTCACCATCAATAAA
CATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTCCACACCATCTCTTCTTTGAGTTGTTTATGGC
CTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTTGTATTAAGTGTCATAATAGCATCAATGTGCA
CATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGGGAAAAATAGTATAGGATGTGAAAGTTTTGAA

>5668_5668_11_APP-CYYR1_APP_chr21_27462259_ENST00000359726_CYYR1_chr21_27938687_ENST00000299340_length(amino acids)=248AA_BP=118
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICM

--------------------------------------------------------------
>5668_5668_12_APP-CYYR1_APP_chr21_27462259_ENST00000359726_CYYR1_chr21_27938687_ENST00000400043_length(transcript)=981nt_BP=555nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCT
ACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGA
TTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAGGACGACTCACATCAACACCGTCTCCTCCT
ATCCTGAATATGAACTCCATGAGGCAGAGATCTTGGTCTATTTTGTTCAACACTCTATTCCAAGCATGTAAGACCAGGCCTGGTACATAA

>5668_5668_12_APP-CYYR1_APP_chr21_27462259_ENST00000359726_CYYR1_chr21_27938687_ENST00000400043_length(amino acids)=226AA_BP=118
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICM

--------------------------------------------------------------
>5668_5668_13_APP-CYYR1_APP_chr21_27462259_ENST00000439274_CYYR1_chr21_27938687_ENST00000299340_length(transcript)=2905nt_BP=221nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG
CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTGTGA
TGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAATAGT
ATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAGGAC
GACTCACATCAACACCGTCTCCTCCTATCCTGGACCACCACCCTACGGTCACGACCACGAGATGGAATACTGTGCAGACTTGCCTCCTCC
ATACTCCCCCACCCCACAGGGTCCAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAAGGAAATAATCTATCTCCCAGAACAG
AACATGTGCCAATGGGCGATCTTGCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTTTTGGG
GTCAGATAATGTGTCAGGTGGAATATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTAATGTT
TGGTTCTATGGAACCACATTTTAAGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAATGTAATTGACAAAATATCTGATAAT
CATGTTGTTTAAGGGCTAGGTGAAGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTGGCCCA
CACAAGGAAGCAACTTTATTCTATATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCATTCATCAATAAATGTATTTTGAGTGC
CTAAGAGTTTACTATGTGCCTAGCACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAGCAATG
ACTAGATTGCTTTGTGAAGCTCTTGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGTAGATGGGTTCATTGGGCCTCAGAAG
TTCTGCTCGTATTTTAGGTGGGTGTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAAAGAGTTGGATCTTATTTATTTAATT
AGGGAGTTAAAACAAGACCAAAAAGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAGCTACTGCCACCTAAAAATCATCTGG
CTTTATAGTGGATCAGAATAAAGGTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTTCCACAGGTAGCAGACACTTCACTTC
CAAGTAAAAGATGAGAAATCAATTATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAACTTGACCATGAAGATACACAACAGA
CTCGCAAAAATAAAGTGGGAAATGAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAATTTTGA
TAATCTGTTCTCTTAAAAAAGTTAATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTACCAAAATGCAAATTTTATGAAGTGC
CTACCTTTATATGTATAAAGCATTTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGACCTTAACATTTATATTTTTATATGAA
TTGTTTCATGTATTTATAAAAATTGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTCATTTTACAATTAAATCTAAAATGCT
TAATCCAATATCATCATCAAAATTCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGAAACAATCAAACAAAGCATTTTAAGG
TGTAAGTTATAGTACCTGTACTTGCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATATATTACTTTCAAATACCTATATTAGA
AAGATATTGATCTGACTGAAATATAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTAAGCAC
TGATGATTTTCTTATATATGAGGATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTTTTCAG
TGCAATTTTAATAGTACATATGCTTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACACTGTGGCTAAGACTCTCAAAGTGCC
AGGGTTTCTGTGATGATTCTGAGAATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAAATAGG
GTTTTCTCATCTTCACCATCAATAAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTCCACAC
CATCTCTTCTTTGAGTTGTTTATGGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATAGATGAGTATTTTTACTATTTGTATT
AAGTGTCATAATAGCATCAATGTGCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTTCATAGATGATGCTTCTTGGGGAAAA
ATAGTATAGGATGTGAAAGTTTTGAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAGTGTTTACAATAAGCAATAAAGTGAA

>5668_5668_13_APP-CYYR1_APP_chr21_27462259_ENST00000439274_CYYR1_chr21_27938687_ENST00000299340_length(amino acids)=192AA_BP=62
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYA
YIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNHRATRVGILRTTHINTVSSYPGPPPYGHDHEMEYCADLPPPYSPTPQGPAQR

--------------------------------------------------------------
>5668_5668_14_APP-CYYR1_APP_chr21_27462259_ENST00000439274_CYYR1_chr21_27938687_ENST00000400043_length(transcript)=647nt_BP=221nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG
CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTGTGA
TGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAATAGT
ATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAGGAC
GACTCACATCAACACCGTCTCCTCCTATCCTGAATATGAACTCCATGAGGCAGAGATCTTGGTCTATTTTGTTCAACACTCTATTCCAAG
CATGTAAGACCAGGCCTGGTACATAATGGGCACTCAGCTGAATGAATGATGAACACAACTCATGAAAAGACCTGAATTAATCATATATCA

>5668_5668_14_APP-CYYR1_APP_chr21_27462259_ENST00000439274_CYYR1_chr21_27938687_ENST00000400043_length(amino acids)=170AA_BP=62
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYA

--------------------------------------------------------------
>5668_5668_15_APP-CYYR1_APP_chr21_27462259_ENST00000440126_CYYR1_chr21_27938687_ENST00000299340_length(transcript)=3290nt_BP=606nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT
GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCA
AAGATTGCAAATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAA
TTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGG
CGACCCGCGTGGGCATCCTCAGGACGACTCACATCAACACCGTCTCCTCCTATCCTGGACCACCACCCTACGGTCACGACCACGAGATGG
AATACTGTGCAGACTTGCCTCCTCCATACTCCCCCACCCCACAGGGTCCAGCACAGCGTTCTCCACCCCCTCCTTATCCTGGAAACGCAA
GGAAATAATCTATCTCCCAGAACAGAACATGTGCCAATGGGCGATCTTGCCTGGAATAAAATGCCTCTACTCAGAAACAGGCAGGAAAGA
ATTGCTCCAAGGAATACTTTTTGGGGTCAGATAATGTGTCAGGTGGAATATCCCTGCTAGGAGATATAGGATTTCTACTCTGCTCAAAGC
TGACCCCATCTGGAGTATTAATGTTTGGTTCTATGGAACCACATTTTAAGAGATCTGCTGATCCACCTAAGCACATTCAGGGAAGAGTAA
TGTAATTGACAAAATATCTGATAATCATGTTGTTTAAGGGCTAGGTGAAGAAAGTTTCAGTATTGATCCTGGAAAAAAAGAAGATCTAAG
TAGGATGGGAGAATGATTTGGCCCACACAAGGAAGCAACTTTATTCTATATAGCTTTAAAAGTCAGAACTAGAATTGTTCATTCTTTCAT
TCATCAATAAATGTATTTTGAGTGCCTAAGAGTTTACTATGTGCCTAGCACTGTTTGAGGTCCTGATGGAAGTTACAGGACGGGTACTCT
GGTTTTAGTACAAGAAAGAGCAATGACTAGATTGCTTTGTGAAGCTCTTGGTAGAGACACGCTCCAGAAGGGATAACAAAATCAAATAGT
AGATGGGTTCATTGGGCCTCAGAAGTTCTGCTCGTATTTTAGGTGGGTGTGAAGTGAATTTCTATATGTCCAGGAGTGAATACAACAGAA
AGAGTTGGATCTTATTTATTTAATTAGGGAGTTAAAACAAGACCAAAAAGACTCAACAGCCGCTTGAAGCCAAGAACTCTTCAATGCCAG
CTACTGCCACCTAAAAATCATCTGGCTTTATAGTGGATCAGAATAAAGGTTATTCTAACTGTGGGGAGAAAAAAAAAATTGTATCAAGTT
CCACAGGTAGCAGACACTTCACTTCCAAGTAAAAGATGAGAAATCAATTATTCCCACAGGATTTTAGGTCAGGGAGCAAAAATCTCAGAA
CTTGACCATGAAGATACACAACAGACTCGCAAAAATAAAGTGGGAAATGAAGTTCAGATTCCCTTCTGTAGATTTCCTTAAAACTATTAT
TTTTTTCTTCTTCGTAAAATTTTGATAATCTGTTCTCTTAAAAAAGTTAATGACACAATTAAGATACTGACATCAAATTGTTGCCTTTTA
CCAAAATGCAAATTTTATGAAGTGCCTACCTTTATATGTATAAAGCATTTAATAAATAATTCTAATGTGCCATATTTTGCTGTGAGTGAC
CTTAACATTTATATTTTTATATGAATTGTTTCATGTATTTATAAAAATTGTATATTGAACATTGGAAATAGATGATTAGATTTTTGTGTC
ATTTTACAATTAAATCTAAAATGCTTAATCCAATATCATCATCAAAATTCAGTGAAATCCCAAAACAGTGCCAAGAATTTTGCTGAATGA
AACAATCAAACAAAGCATTTTAAGGTGTAAGTTATAGTACCTGTACTTGCAGATAAGAAGCTTACTATATCATTATTATAAGTAGCATAT
ATTACTTTCAAATACCTATATTAGAAAGATATTGATCTGACTGAAATATAACCTACCTGCCAGTAAGGTCCAAAGGCTGAATTTGTTTTG
AATGAGTTCCTTGATCTTTAAGCACTGATGATTTTCTTATATATGAGGATGCAAAGCATTCAAGAGTTTCAGCCTGTTCTGGTGAGGGGC
TCCCTGACTTACATAAAGTTTTCAGTGCAATTTTAATAGTACATATGCTTTAATTTATTTTTCTTCTGCGTGTGGTCAGACCCAATTACA
CTGTGGCTAAGACTCTCAAAGTGCCAGGGTTTCTGTGATGATTCTGAGAATGCTGAATACAAATATACCTTATATTCTTTAAGGAAAACG
GAAAGGAAAGATCAGCAGAAATAGGGTTTTCTCATCTTCACCATCAATAAACATTTATTGCGTACCTCCTATATTCTGCAAATTTTCCCC
AAATAGAAGCCAGTTCAGTCCACACCATCTCTTCTTTGAGTTGTTTATGGCCTCCCTTAAGGCATTTTACAAACCCATAAGCCTACAATA
GATGAGTATTTTTACTATTTGTATTAAGTGTCATAATAGCATCAATGTGCACATTACCAGTATAGACTGTTGGAGTTCACTGATTGTTTT
CATAGATGATGCTTCTTGGGGAAAAATAGTATAGGATGTGAAAGTTTTGAATTACGGTTATTTAAAAACTAACATTTGCTATGGCCAAAG

>5668_5668_15_APP-CYYR1_APP_chr21_27462259_ENST00000440126_CYYR1_chr21_27938687_ENST00000299340_length(amino acids)=252AA_BP=122
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAI

--------------------------------------------------------------
>5668_5668_16_APP-CYYR1_APP_chr21_27462259_ENST00000440126_CYYR1_chr21_27938687_ENST00000400043_length(transcript)=1032nt_BP=606nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT
GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGCCTTGCTCAGTGTGGCA
AAGATTGCAAATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATCCTCTCGGGCACTGCAA
TTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGCATGAAGAACCACAGGG
CGACCCGCGTGGGCATCCTCAGGACGACTCACATCAACACCGTCTCCTCCTATCCTGAATATGAACTCCATGAGGCAGAGATCTTGGTCT
ATTTTGTTCAACACTCTATTCCAAGCATGTAAGACCAGGCCTGGTACATAATGGGCACTCAGCTGAATGAATGATGAACACAACTCATGA

>5668_5668_16_APP-CYYR1_APP_chr21_27462259_ENST00000440126_CYYR1_chr21_27938687_ENST00000400043_length(amino acids)=230AA_BP=122
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAI

--------------------------------------------------------------
>5668_5668_17_APP-CYYR1_APP_chr21_27462259_ENST00000448388_CYYR1_chr21_27938687_ENST00000299340_length(transcript)=3126nt_BP=442nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA
GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGC
CTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATC
CTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGC
ATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAGGACGACTCACATCAACACCGTCTCCTCCTATCCTGGACCACCACCCTACGGT
CACGACCACGAGATGGAATACTGTGCAGACTTGCCTCCTCCATACTCCCCCACCCCACAGGGTCCAGCACAGCGTTCTCCACCCCCTCCT
TATCCTGGAAACGCAAGGAAATAATCTATCTCCCAGAACAGAACATGTGCCAATGGGCGATCTTGCCTGGAATAAAATGCCTCTACTCAG
AAACAGGCAGGAAAGAATTGCTCCAAGGAATACTTTTTGGGGTCAGATAATGTGTCAGGTGGAATATCCCTGCTAGGAGATATAGGATTT
CTACTCTGCTCAAAGCTGACCCCATCTGGAGTATTAATGTTTGGTTCTATGGAACCACATTTTAAGAGATCTGCTGATCCACCTAAGCAC
ATTCAGGGAAGAGTAATGTAATTGACAAAATATCTGATAATCATGTTGTTTAAGGGCTAGGTGAAGAAAGTTTCAGTATTGATCCTGGAA
AAAAAGAAGATCTAAGTAGGATGGGAGAATGATTTGGCCCACACAAGGAAGCAACTTTATTCTATATAGCTTTAAAAGTCAGAACTAGAA
TTGTTCATTCTTTCATTCATCAATAAATGTATTTTGAGTGCCTAAGAGTTTACTATGTGCCTAGCACTGTTTGAGGTCCTGATGGAAGTT
ACAGGACGGGTACTCTGGTTTTAGTACAAGAAAGAGCAATGACTAGATTGCTTTGTGAAGCTCTTGGTAGAGACACGCTCCAGAAGGGAT
AACAAAATCAAATAGTAGATGGGTTCATTGGGCCTCAGAAGTTCTGCTCGTATTTTAGGTGGGTGTGAAGTGAATTTCTATATGTCCAGG
AGTGAATACAACAGAAAGAGTTGGATCTTATTTATTTAATTAGGGAGTTAAAACAAGACCAAAAAGACTCAACAGCCGCTTGAAGCCAAG
AACTCTTCAATGCCAGCTACTGCCACCTAAAAATCATCTGGCTTTATAGTGGATCAGAATAAAGGTTATTCTAACTGTGGGGAGAAAAAA
AAAATTGTATCAAGTTCCACAGGTAGCAGACACTTCACTTCCAAGTAAAAGATGAGAAATCAATTATTCCCACAGGATTTTAGGTCAGGG
AGCAAAAATCTCAGAACTTGACCATGAAGATACACAACAGACTCGCAAAAATAAAGTGGGAAATGAAGTTCAGATTCCCTTCTGTAGATT
TCCTTAAAACTATTATTTTTTTCTTCTTCGTAAAATTTTGATAATCTGTTCTCTTAAAAAAGTTAATGACACAATTAAGATACTGACATC
AAATTGTTGCCTTTTACCAAAATGCAAATTTTATGAAGTGCCTACCTTTATATGTATAAAGCATTTAATAAATAATTCTAATGTGCCATA
TTTTGCTGTGAGTGACCTTAACATTTATATTTTTATATGAATTGTTTCATGTATTTATAAAAATTGTATATTGAACATTGGAAATAGATG
ATTAGATTTTTGTGTCATTTTACAATTAAATCTAAAATGCTTAATCCAATATCATCATCAAAATTCAGTGAAATCCCAAAACAGTGCCAA
GAATTTTGCTGAATGAAACAATCAAACAAAGCATTTTAAGGTGTAAGTTATAGTACCTGTACTTGCAGATAAGAAGCTTACTATATCATT
ATTATAAGTAGCATATATTACTTTCAAATACCTATATTAGAAAGATATTGATCTGACTGAAATATAACCTACCTGCCAGTAAGGTCCAAA
GGCTGAATTTGTTTTGAATGAGTTCCTTGATCTTTAAGCACTGATGATTTTCTTATATATGAGGATGCAAAGCATTCAAGAGTTTCAGCC
TGTTCTGGTGAGGGGCTCCCTGACTTACATAAAGTTTTCAGTGCAATTTTAATAGTACATATGCTTTAATTTATTTTTCTTCTGCGTGTG
GTCAGACCCAATTACACTGTGGCTAAGACTCTCAAAGTGCCAGGGTTTCTGTGATGATTCTGAGAATGCTGAATACAAATATACCTTATA
TTCTTTAAGGAAAACGGAAAGGAAAGATCAGCAGAAATAGGGTTTTCTCATCTTCACCATCAATAAACATTTATTGCGTACCTCCTATAT
TCTGCAAATTTTCCCCAAATAGAAGCCAGTTCAGTCCACACCATCTCTTCTTTGAGTTGTTTATGGCCTCCCTTAAGGCATTTTACAAAC
CCATAAGCCTACAATAGATGAGTATTTTTACTATTTGTATTAAGTGTCATAATAGCATCAATGTGCACATTACCAGTATAGACTGTTGGA
GTTCACTGATTGTTTTCATAGATGATGCTTCTTGGGGAAAAATAGTATAGGATGTGAAAGTTTTGAATTACGGTTATTTAAAAACTAACA

>5668_5668_17_APP-CYYR1_APP_chr21_27462259_ENST00000448388_CYYR1_chr21_27938687_ENST00000299340_length(amino acids)=221AA_BP=91
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNHRATRVGILRTTHINTVSSYPGP

--------------------------------------------------------------
>5668_5668_18_APP-CYYR1_APP_chr21_27462259_ENST00000448388_CYYR1_chr21_27938687_ENST00000400043_length(transcript)=868nt_BP=442nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA
GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGATGATTGC
CTTGCTCAGTGTGGCAAAGATTGCAAATCTTACTGCTGTGATGGAACCACGCCCTACTGTTGCTCCTACTACGCTTATATTGGGAATATC
CTCTCGGGCACTGCAATTGCGGGCATTGTTTTTGGAATAGTATTTATCATGGGGGTCATTGCTGGGATTGCCATATGCATCTGCATGTGC
ATGAAGAACCACAGGGCGACCCGCGTGGGCATCCTCAGGACGACTCACATCAACACCGTCTCCTCCTATCCTGAATATGAACTCCATGAG
GCAGAGATCTTGGTCTATTTTGTTCAACACTCTATTCCAAGCATGTAAGACCAGGCCTGGTACATAATGGGCACTCAGCTGAATGAATGA

>5668_5668_18_APP-CYYR1_APP_chr21_27462259_ENST00000448388_CYYR1_chr21_27938687_ENST00000400043_length(amino acids)=199AA_BP=91
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LDDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNHRATRVGILRTTHINTVSSYPEY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for APP-CYYR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318732_751118.33333333333333771.0G(o)-alpha
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316732_751118.33333333333333696.0G(o)-alpha
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215732_75162.333333333333336640.0G(o)-alpha
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317732_751118.33333333333333752.0G(o)-alpha
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317732_751118.33333333333333753.0G(o)-alpha
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317732_751118.33333333333333715.0G(o)-alpha
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317732_751113.33333333333333747.0G(o)-alpha
HgeneAPPchr21:27462259chr21:27938687ENST00000346798-318695_722118.33333333333333771.0PSEN1
HgeneAPPchr21:27462259chr21:27938687ENST00000348990-316695_722118.33333333333333696.0PSEN1
HgeneAPPchr21:27462259chr21:27938687ENST00000354192-215695_72262.333333333333336640.0PSEN1
HgeneAPPchr21:27462259chr21:27938687ENST00000357903-317695_722118.33333333333333752.0PSEN1
HgeneAPPchr21:27462259chr21:27938687ENST00000358918-317695_722118.33333333333333753.0PSEN1
HgeneAPPchr21:27462259chr21:27938687ENST00000359726-317695_722118.33333333333333715.0PSEN1
HgeneAPPchr21:27462259chr21:27938687ENST00000440126-317695_722113.33333333333333747.0PSEN1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APP-CYYR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APP-CYYR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPPC0002395Alzheimer's Disease63CTD_human;UNIPROT
HgeneAPPC0011265Presenile dementia35CTD_human
HgeneAPPC0276496Familial Alzheimer Disease (FAD)35CTD_human
HgeneAPPC0494463Alzheimer Disease, Late Onset35CTD_human
HgeneAPPC0546126Acute Confusional Senile Dementia35CTD_human
HgeneAPPC0750900Alzheimer's Disease, Focal Onset35CTD_human
HgeneAPPC0750901Alzheimer Disease, Early Onset35CTD_human
HgeneAPPC0025261Memory Disorders16CTD_human
HgeneAPPC0233794Memory impairment16CTD_human
HgeneAPPC0751292Age-Related Memory Disorders16CTD_human
HgeneAPPC0751293Memory Disorder, Semantic16CTD_human
HgeneAPPC0751294Memory Disorder, Spatial16CTD_human
HgeneAPPC0751295Memory Loss16CTD_human
HgeneAPPC0027746Nerve Degeneration11CTD_human
HgeneAPPC0023186Learning Disorders8CTD_human
HgeneAPPC0751262Adult Learning Disorders8CTD_human
HgeneAPPC0751263Learning Disturbance8CTD_human
HgeneAPPC0751265Learning Disabilities8CTD_human
HgeneAPPC1330966Developmental Academic Disorder8CTD_human
HgeneAPPC2751536CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED7CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAPPC0009241Cognition Disorders5CTD_human
HgeneAPPC0011570Mental Depression5PSYGENET
HgeneAPPC0011581Depressive disorder5PSYGENET
HgeneAPPC0234544Todd Paralysis5CTD_human
HgeneAPPC0522224Paralysed5CTD_human
HgeneAPPC0497327Dementia3CTD_human;GENOMICS_ENGLAND
HgeneAPPC2931672Cerebral hemorrhage with amyloidosis, hereditary, Dutch type3CTD_human;ORPHANET
HgeneAPPC0270715Degenerative Diseases, Central Nervous System2CTD_human
HgeneAPPC0333463Senile Plaques2CTD_human
HgeneAPPC0524851Neurodegenerative Disorders2CTD_human
HgeneAPPC0600467Neurogenic Inflammation2CTD_human
HgeneAPPC0751733Degenerative Diseases, Spinal Cord2CTD_human
HgeneAPPC2751494CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ARCTIC VARIANT2CTD_human
HgeneAPPC2936349Plaque, Amyloid2CTD_human
HgeneAPPC3888307CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, FLEMISH VARIANT2CTD_human
HgeneAPPC3888308CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ITALIAN VARIANT2CTD_human
HgeneAPPC3888309CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, IOWA VARIANT2CTD_human
HgeneAPPC0002622Amnesia1CTD_human
HgeneAPPC0002726Amyloidosis1CTD_human
HgeneAPPC0003469Anxiety Disorders1CTD_human
HgeneAPPC0005586Bipolar Disorder1PSYGENET
HgeneAPPC0006111Brain Diseases1CTD_human
HgeneAPPC0011573Endogenous depression1PSYGENET
HgeneAPPC0016667Fragile X Syndrome1CTD_human
HgeneAPPC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneAPPC0027540Necrosis1CTD_human
HgeneAPPC0033141Cardiomyopathies, Primary1CTD_human
HgeneAPPC0036529Myocardial Diseases, Secondary1CTD_human
HgeneAPPC0036572Seizures1GENOMICS_ENGLAND
HgeneAPPC0037928Spinal Cord Diseases1CTD_human
HgeneAPPC0038002Splenomegaly1CTD_human
HgeneAPPC0038454Cerebrovascular accident1GENOMICS_ENGLAND
HgeneAPPC0043094Weight Gain1CTD_human
HgeneAPPC0085220Cerebral Amyloid Angiopathy1CTD_human
HgeneAPPC0085584Encephalopathies1CTD_human
HgeneAPPC0231341Premature aging syndrome1CTD_human
HgeneAPPC0233750Hysterical amnesia1CTD_human
HgeneAPPC0233796Temporary Amnesia1CTD_human
HgeneAPPC0234985Mental deterioration1CTD_human
HgeneAPPC0236795Dissociative Amnesia1CTD_human
HgeneAPPC0262497Global Amnesia1CTD_human
HgeneAPPC0270612Leukoencephalopathy1GENOMICS_ENGLAND
HgeneAPPC0338582Sporadic Cerebral Amyloid Angiopathy1CTD_human
HgeneAPPC0338630Senile Paranoid Dementia1CTD_human
HgeneAPPC0338656Impaired cognition1CTD_human
HgeneAPPC0376280Anxiety States, Neurotic1CTD_human
HgeneAPPC0553692Brain hemorrhage1GENOMICS_ENGLAND
HgeneAPPC0750906Tactile Amnesia1CTD_human
HgeneAPPC0750907Amnestic State1CTD_human
HgeneAPPC0751071Familial Dementia1CTD_human
HgeneAPPC0751156FRAXA Syndrome1CTD_human
HgeneAPPC0751157FRAXE Syndrome1CTD_human
HgeneAPPC0878544Cardiomyopathies1CTD_human
HgeneAPPC0948008Ischemic stroke1GENOMICS_ENGLAND
HgeneAPPC1270972Mild cognitive disorder1CTD_human
HgeneAPPC1279420Anxiety neurosis (finding)1CTD_human