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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APP-PRKAA1 (FusionGDB2 ID:HG351TG5562)

Fusion Gene Summary for APP-PRKAA1

check button Fusion gene summary
Fusion gene informationFusion gene name: APP-PRKAA1
Fusion gene ID: hg351tg5562
HgeneTgene
Gene symbol

APP

PRKAA1

Gene ID

351

5562

Gene nameamyloid beta precursor proteinprotein kinase AMP-activated catalytic subunit alpha 1
SynonymsAAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4AMPK|AMPKa1
Cytomap('APP')('PRKAA1')

21q21.3

5p13.1

Type of geneprotein-codingprotein-coding
Descriptionamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei5'-AMP-activated protein kinase catalytic subunit alpha-15'-AMP-activated protein kinase, catalytic alpha-1 chainACACA kinaseAMP -activate kinase alpha 1 subunitAMP-activated protein kinase, catalytic, alpha-1AMPK alpha 1AMPK subunit alpha-1HMGCR k
Modification date2020032920200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000474136, ENST00000346798, 
ENST00000348990, ENST00000354192, 
ENST00000357903, ENST00000358918, 
ENST00000359726, ENST00000439274, 
ENST00000440126, ENST00000448388, 
Fusion gene scores* DoF score31 X 25 X 12=93009 X 8 X 4=288
# samples 3310
** MAII scorelog2(33/9300*10)=-4.81669278663694
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APP [Title/Abstract] AND PRKAA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPP(27423315)-PRKAA1(40775605), # samples:1
Anticipated loss of major functional domain due to fusion event.APP-PRKAA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-PRKAA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-PRKAA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-PRKAA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

HgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

HgeneAPP

GO:1905606

regulation of presynapse assembly

19726636

TgenePRKAA1

GO:0006468

protein phosphorylation

17028174

TgenePRKAA1

GO:0010508

positive regulation of autophagy

22012985

TgenePRKAA1

GO:0010628

positive regulation of gene expression

17028174


check buttonFusion gene breakpoints across APP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PRKAA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5718APPchr21

27423315

-PRKAA1chr5

40775605

-


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Fusion Gene ORF analysis for APP-PRKAA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000474136ENST00000296800APPchr21

27423315

-PRKAA1chr5

40775605

-
5UTR-3CDSENST00000474136ENST00000354209APPchr21

27423315

-PRKAA1chr5

40775605

-
5UTR-3CDSENST00000474136ENST00000397128APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000346798ENST00000296800APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000346798ENST00000354209APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000346798ENST00000397128APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000348990ENST00000296800APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000348990ENST00000354209APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000348990ENST00000397128APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000354192ENST00000296800APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000354192ENST00000354209APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000354192ENST00000397128APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000357903ENST00000296800APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000357903ENST00000354209APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000357903ENST00000397128APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000358918ENST00000296800APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000358918ENST00000354209APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000358918ENST00000397128APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000359726ENST00000296800APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000359726ENST00000354209APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000359726ENST00000397128APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000439274ENST00000296800APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000439274ENST00000354209APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000439274ENST00000397128APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000440126ENST00000296800APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000440126ENST00000354209APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000440126ENST00000397128APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000448388ENST00000296800APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000448388ENST00000354209APPchr21

27423315

-PRKAA1chr5

40775605

-
In-frameENST00000448388ENST00000397128APPchr21

27423315

-PRKAA1chr5

40775605

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346798APPchr2127423315-ENST00000397128PRKAA1chr540775605-5506696342106690
ENST00000346798APPchr2127423315-ENST00000354209PRKAA1chr540775605-2160696342151705
ENST00000346798APPchr2127423315-ENST00000296800PRKAA1chr540775605-1576696341077347
ENST00000354192APPchr2127423315-ENST00000397128PRKAA1chr540775605-54316211272031634
ENST00000354192APPchr2127423315-ENST00000354209PRKAA1chr540775605-20856211272076649
ENST00000354192APPchr2127423315-ENST00000296800PRKAA1chr540775605-15016211271002291
ENST00000348990APPchr2127423315-ENST00000397128PRKAA1chr540775605-56198091472219690
ENST00000348990APPchr2127423315-ENST00000354209PRKAA1chr540775605-22738091472264705
ENST00000348990APPchr2127423315-ENST00000296800PRKAA1chr540775605-16898091471190347
ENST00000357903APPchr2127423315-ENST00000397128PRKAA1chr540775605-56398291672239690
ENST00000357903APPchr2127423315-ENST00000354209PRKAA1chr540775605-22938291672284705
ENST00000357903APPchr2127423315-ENST00000296800PRKAA1chr540775605-17098291671210347
ENST00000358918APPchr2127423315-ENST00000397128PRKAA1chr540775605-56728622002272690
ENST00000358918APPchr2127423315-ENST00000354209PRKAA1chr540775605-23268622002317705
ENST00000358918APPchr2127423315-ENST00000296800PRKAA1chr540775605-17428622001243347
ENST00000359726APPchr2127423315-ENST00000397128PRKAA1chr540775605-56728622002272690
ENST00000359726APPchr2127423315-ENST00000354209PRKAA1chr540775605-23268622002317705
ENST00000359726APPchr2127423315-ENST00000296800PRKAA1chr540775605-17428622001243347
ENST00000448388APPchr2127423315-ENST00000397128PRKAA1chr540775605-55597491682159663
ENST00000448388APPchr2127423315-ENST00000354209PRKAA1chr540775605-22137491682204678
ENST00000448388APPchr2127423315-ENST00000296800PRKAA1chr540775605-16297491681130320
ENST00000440126APPchr2127423315-ENST00000397128PRKAA1chr540775605-57239132392323694
ENST00000440126APPchr2127423315-ENST00000354209PRKAA1chr540775605-23779132392368709
ENST00000440126APPchr2127423315-ENST00000296800PRKAA1chr540775605-17939132391294351
ENST00000439274APPchr2127423315-ENST00000397128PRKAA1chr540775605-5338528341938634
ENST00000439274APPchr2127423315-ENST00000354209PRKAA1chr540775605-1992528341983649
ENST00000439274APPchr2127423315-ENST00000296800PRKAA1chr540775605-140852834909291

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346798ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0001890690.999811
ENST00000346798ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0022005270.99779946
ENST00000346798ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0003023910.9996977
ENST00000354192ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0001787480.99982125
ENST00000354192ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0015893060.9984107
ENST00000354192ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0003892580.9996107
ENST00000348990ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0001986360.99980134
ENST00000348990ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.002896420.9971035
ENST00000348990ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0004154560.9995845
ENST00000357903ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0001998770.99980015
ENST00000357903ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0031124320.9968876
ENST00000357903ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0004375780.99956244
ENST00000358918ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0002074470.9997925
ENST00000358918ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0034168880.99658316
ENST00000358918ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0005270110.99947304
ENST00000359726ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0002074470.9997925
ENST00000359726ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0034168880.99658316
ENST00000359726ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0005270110.99947304
ENST00000448388ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0002124530.9997875
ENST00000448388ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0025368250.9974631
ENST00000448388ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.000253570.9997464
ENST00000440126ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0002208240.99977916
ENST00000440126ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0011477070.99885225
ENST00000440126ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0002342750.9997657
ENST00000439274ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0001738410.99982613
ENST00000439274ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0013153670.9986846
ENST00000439274ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0003212780.99967873

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Fusion Genomic Features for APP-PRKAA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for APP-PRKAA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:27423315/chr5:40775605)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-51828_189220771.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-51628_189220696.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-51728_189220752.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-51728_189220753.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-51728_189220715.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-51728_189215747.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518131_189220771.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518181_188220771.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-51828_123220771.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-51896_110220771.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516131_189220696.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516181_188220696.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-51628_123220696.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-51696_110220696.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-41528_123164640.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-41596_110164640.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517131_189220752.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517181_188220752.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-51728_123220752.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-51796_110220752.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517131_189220753.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517181_188220753.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-51728_123220753.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-51796_110220753.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517131_189220715.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517181_188220715.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-51728_123220715.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-51796_110220715.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517131_189215747.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517181_188215747.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-51728_123215747.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-51796_110215747.0RegionHeparin-binding
TgenePRKAA1chr21:27423315chr5:40775605ENST00000354209110302_38189575.0RegionNote=AIS
TgenePRKAA1chr21:27423315chr5:40775605ENST0000039712819302_38189560.0RegionNote=AIS

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518230_260220771.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518274_280220771.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516230_260220696.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516274_280220696.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415230_260164640.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415274_280164640.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517230_260220752.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517274_280220752.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517230_260220753.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517274_280220753.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517230_260220715.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517274_280220715.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517230_260215747.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517274_280215747.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518374_565220771.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516374_565220696.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-41528_189164640.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415374_565164640.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517374_565220752.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517374_565220753.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517374_565220715.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517374_565215747.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518344_365220771.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518724_734220771.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516344_365220696.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516724_734220696.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415344_365164640.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415724_734164640.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517344_365220752.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517724_734220752.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517344_365220753.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517724_734220753.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517344_365220715.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517724_734220715.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517344_365215747.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517724_734215747.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518391_423220771.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518491_522220771.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518523_540220771.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516391_423220696.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516491_522220696.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516523_540220696.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415131_189164640.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415181_188164640.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415391_423164640.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415491_522164640.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415523_540164640.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517391_423220752.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517491_522220752.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517523_540220752.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517391_423220753.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517491_522220753.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517523_540220753.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517391_423220715.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517491_522220715.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517523_540220715.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517391_423215747.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517491_522215747.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517523_540215747.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-51818_701220771.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518723_770220771.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-51618_701220696.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516723_770220696.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-41518_701164640.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415723_770164640.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-51718_701220752.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517723_770220752.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-51718_701220753.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517723_770220753.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-51718_701220715.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517723_770220715.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-51718_701215747.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517723_770215747.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518702_722220771.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516702_722220696.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415702_722164640.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517702_722220752.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517702_722220753.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517702_722220715.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517702_722215747.0TransmembraneHelical
TgenePRKAA1chr21:27423315chr5:40775605ENST0000035420911027_27989575.0DomainProtein kinase
TgenePRKAA1chr21:27423315chr5:40775605ENST000003971281927_27989560.0DomainProtein kinase
TgenePRKAA1chr21:27423315chr5:40775605ENST0000035420911033_4189575.0Nucleotide bindingATP
TgenePRKAA1chr21:27423315chr5:40775605ENST000003971281933_4189560.0Nucleotide bindingATP


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Fusion Gene Sequence for APP-PRKAA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5701_5701_1_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1576nt_BP=696nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA
ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC
CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA
GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG
CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC
TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATC
TGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCG
GCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCT
TGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACC
CAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAATTTACTAACTACCAGCATTGAGA
ACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACT
ATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTCACCCAAACCATGCTTATTTGTGT
GAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAAT
GAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTA
ATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTCAGGACATGGAGACTG
TGGAAAGTTGTTATTTAAATAAATAAAAAGAAATGTTATAACTGTG

>5701_5701_1_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRDCNIIRILTSQFTNYQH

--------------------------------------------------------------
>5701_5701_2_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2160nt_BP=696nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA
ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC
CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA
GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG
CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC
TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATC
TGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGT
AGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAG
GCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAA
CATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGG
CCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCT
TTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGA
TCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATC
ATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTA
CAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTT
GGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACC
AAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAG
TCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTT
GCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGA
TTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTG
CCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGT
TGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAA


>5701_5701_2_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE
KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI
LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL
KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP
QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA
KSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_3_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5506nt_BP=696nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA
TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA
ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC
CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA
GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG
CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC
TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATC
TGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCG
GCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCT
TGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACC
CAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTT
ATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTT
AAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATG
GTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATG
TGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCAT
AATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGAC
TCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAA
ACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAAT
CAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAAT
GAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGAC
TGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGA
AGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGA
GATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCAC
AGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACAT
GATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGT
GAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTC
ATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGT
TTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTT
TTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGA
TTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGT
TTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCC
ACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTA
GCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACAC
AAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCAT
CATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCT
TACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAA
GCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCTATATATGTATAGATACAGCTAGT
TATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATC
ACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATAT
CATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTAC
ATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGG
TCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCATTCT
TAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGTATCATTTATATTT
GCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCTATTTTAAGAATCATA
TTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGA
CTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATT
CAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCT
TTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTT
GTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAAT
TGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTGCAC
TTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGT
GTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATT
TTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGAT
GTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAA
ATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAA
TAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCT
AGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTG
TGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAA
TAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATT
TGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAATATGATATAATAAAGAAAAACTC
CATTTATCATCTGTTA

>5701_5701_3_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH
VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL
SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL
GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN
YRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_4_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1689nt_BP=809nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC
CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC
AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG
AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA
GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGG
TACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGA
AGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGAT
TTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTT
TTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAA
TTTACTAACTACCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTA
AGAATAACTCTTTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTC
ACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGT
TGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCA
TCTTTTTTTTAAATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAA
AACAATTCAGGACATGGAGACTGTGGAAAGTTGTTATTTAAATAAATAAAAAGAAATGTTATAACTGTG

>5701_5701_4_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRDCNIIRILTSQFTNYQH

--------------------------------------------------------------
>5701_5701_5_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2273nt_BP=809nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC
CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC
AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG
AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA
GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGG
TACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGA
AGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTT
TCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAG
ATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTA
ATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTT
GATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTT
TTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAA
TATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAA
GAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATG
AATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTA
CCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCA
AAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGG
AAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTG
GATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGA
TCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTG
ACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAA
ATTCTTGCACAATAAACAGAAAA

>5701_5701_5_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE
KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI
LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL
KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP
QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA
KSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_6_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5619nt_BP=809nt
AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA
GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC
GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG
AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG
TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC
CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC
AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG
AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA
GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGG
TACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGA
AGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGAT
TTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTT
TTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGC
AGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGG
ATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATC
AAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGAT
GATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCT
TTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCT
TTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGAT
GAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATT
ATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCT
GTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAA
ATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCT
GAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGA
AGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGC
AATAAGCATGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGC
AATTTGCACAGGGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTAT
GTATATAGCATAATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAA
TATTAATTTACATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCC
AAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTC
TTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAAC
CTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTT
CGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAG
TGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCA
GACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAA
TATTCCCACGATATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAA
TTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGAT
TCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGA
AAAATTGAAAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCT
ATATATGTATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATT
TGGATGTTACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTG
TAAAAGTAATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAA
ACTAGGATCCAATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAAC
AAATCAATTCTATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACA
CTGATATTTTTTTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATG
ATAATATTGTATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATA
TTTTTTCTATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTC
ATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCT
TTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTAT
TTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGAC
TGTATTTTTAAAGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCA
ATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATT
TTGAAAATATTTAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGA
AATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGG
TAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTA
CTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATG
TAAAAATTTTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCT
AATTTAAAATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATG
ATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCT
AGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCT
TTCCCTCATCTTCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATT
GTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAA
TATGATATAATAAAGAAAAACTCCATTTATCATCTGTTA

>5701_5701_6_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH
VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL
SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL
GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN
YRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_7_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1501nt_BP=621nt
GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC
GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT
GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA
GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA
ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA
CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA
CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGT
CATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGA
TGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACC
TGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAAC
AAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAATTTACTAA
CTACCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAAC
TCTTTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTCACCCAAAC
CATGCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAG
ACTGCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTT
TTAAATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTC
AGGACATGGAGACTGTGGAAAGTTGTTATTTAAATAAATAAAAAGAAATGTTATAACTGTG

>5701_5701_7_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=291AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV
ISGRDCNIIRILTSQFTNYQH

--------------------------------------------------------------
>5701_5701_8_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2085nt_BP=621nt
GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC
GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT
GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA
GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA
ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA
CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA
CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGT
CATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATC
TGATGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGT
GGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGA
TTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGG
AAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGA
CCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACA
TATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTT
TCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGT
TCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGC
CAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTT
GGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCA
TTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGT
AAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAG
AACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAG
CAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACT
TGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGC
ACAATAAACAGAAAA

>5701_5701_8_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=649AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATI
KDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNP
VTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
SHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_9_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5431nt_BP=621nt
GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC
GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT
GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA
GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA
ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA
CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA
CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGT
CATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGA
TGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACC
TGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAAC
AAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGT
TATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTA
TACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATAT
CAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGC
CTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGT
TGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGA
TGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAA
TCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGA
AGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAG
CACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGA
AGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCA
AGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACAC
AATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCA
TGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCA
CAGGGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAG
CATAATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATT
TACATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTT
TATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATAT
CCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCT
CCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTT
TAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGA
TTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAAT
TTAAATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCA
CGATATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAA
ATTCCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCA
TAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGAAAAATTGA
AAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCTATATATGT
ATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTT
ACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTA
ATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGAT
CCAATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAAT
TCTATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATT
TTTTTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATT
GTATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCT
ATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTCATGATAGC
TTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCC
AGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTT
TATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTT
TAAAGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATA
GGACCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAAT
ATTTAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAA
CCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAG
GCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCT
TGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATGTAAAAATT
TTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATTTAAA
ATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATA
CAAAATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGG
AACTCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCA
TCTTCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAG
GTAGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAATATGATAT
AATAAAGAAAAACTCCATTTATCATCTGTTA

>5701_5701_9_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=634AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV
ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK
YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERV
PFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV
DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIK
ILAQ

--------------------------------------------------------------
>5701_5701_10_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1709nt_BP=829nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC
AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG
ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA
AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG
TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA
CAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTG
ATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGC
ATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACA
TGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTA
TAAGAATTTTAACCTCTCAATTTACTAACTACCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAAC
AGGAGAATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAA
TGAACTTTTAATAACTTTTCACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATT
TTCTATTTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAAT
TTTAGATTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTAT
CTTAATTCTTTTAGGAATAAAACAATTCAGGACATGGAGACTGTGGAAAGTTGTTATTTAAATAAATAAAAAGAAATGTTATAACTGTG

>5701_5701_10_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRDCNIIRILTSQFTNYQH

--------------------------------------------------------------
>5701_5701_11_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2293nt_BP=829nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC
AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG
ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA
AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG
TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA
CAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTG
ATTATATCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGC
GTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTG
ATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCA
ACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTAT
TATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAA
ATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGT
TTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTG
AAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAA
TAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTC
GGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAAC
ACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCA
AACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGA
GTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTG
CTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAG
TTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGA
TGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAA

>5701_5701_11_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE
KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI
LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL
KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP
QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA
KSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_12_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5639nt_BP=829nt
CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG
TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT
TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG
CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA
CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC
AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG
ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA
AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG
TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA
CAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTG
ATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGC
ATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACA
TGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCC
CAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTT
TTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATC
CCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCAT
ATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACA
ACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGG
CGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAA
GGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTC
AAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGC
GTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATT
TCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCC
AAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTG
ACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACT
TTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGA
GGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTT
TGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTA
GTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATA
AATATTTGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTA
GTAACAGTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTG
TGGTCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCC
ACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCC
ACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATG
GTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAG
CACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATA
AATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGAT
TATGTATCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTA
TGAACATTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGT
CATTTGTTTTCTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGC
TTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCT
AAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTC
TTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATT
ATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTT
CCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGA
TAAAATTGGTATCGTGTATGATAATATTGTATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTT
CCCATTGCAACAGAGCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGA
TGATAATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTC
AAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAA
ATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGT
TCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGG
GGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCAT
TTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTT
TTTTAAGCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAAT
TGTTACTAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGAC
TTTATGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTA
TAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGG
GAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTA
GTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTA
ATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCA
AATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCAC
ATACAACATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTT
CAGCTTCCTTGATTTAGAAATATGATATAATAAAGAAAAACTCCATTTATCATCTGTTA

>5701_5701_12_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH
VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL
SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL
GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN
YRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_13_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1742nt_BP=862nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT
GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT
GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG
ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG
TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAAC
AGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGA
ATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCAC
CAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAATTTACTAACTACCAGCATTGAGAACATGAAGATATTT
GTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACTATACTACTGAAATT
GAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTCACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATC
TTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAA
AATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTAATGTCAAAAATTAT
TTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTCAGGACATGGAGACTGTGGAAAGTTGTTAT
TTAAATAAATAAAAAGAAATGTTATAACTGTG

>5701_5701_13_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRDCNIIRILTSQFTNYQH

--------------------------------------------------------------
>5701_5701_14_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2326nt_BP=862nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT
GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT
GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG
ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG
TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCT
CCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCC
ATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATG
GTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATA
TATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATAT
GTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGG
CCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCA
TGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACC
AGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCAC
CTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATA
CCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAA
ATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGA
AGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTG
ATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATT
CAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAA
GACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAA

>5701_5701_14_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE
KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI
LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL
KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP
QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA
KSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_15_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5672nt_BP=862nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT
GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT
GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG
ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG
TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAAC
AGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGA
ATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCAC
CAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCC
TTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGA
TTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACC
TTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGT
GCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGA
GAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTG
AAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAA
GGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATT
ATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTAT
ACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGA
GATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCT
CATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATC
TAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCC
ATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAA
AGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTATAGGTCTC
AGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTCATATATTATTACGT
GTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTT
AACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTG
TCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAG
CTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCC
CAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCT
CCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCA
AAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGTTCTTTTT
GTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTA
TTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGT
GCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATATCT
ACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATG
CATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACT
TCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCC
ATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGT
TATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATTTGTTTTG
GGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCATTCTTAATTGCATCACAC
AATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGTATCATTTATATTTGCCTTATGTTAACT
TTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTATTT
TTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTG
ACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTG
AAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAA
TTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAA
GTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAA
ACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTGCACTTCTATAAATAGTA
TGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAAC
AGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTT
ATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTT
GCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTG
AGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCT
TTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTT
TGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCA
CCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAATAGAAATTTTATTT
CCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTAT
ATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAATATGATATAATAAAGAAAAACTCCATTTATCATCTGT
TA

>5701_5701_15_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH
VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL
SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL
GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN
YRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_16_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1742nt_BP=862nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT
GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT
GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG
ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG
TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAAC
AGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGA
ATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCAC
CAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAATTTACTAACTACCAGCATTGAGAACATGAAGATATTT
GTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACTATACTACTGAAATT
GAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTCACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATC
TTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAA
AATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTAATGTCAAAAATTAT
TTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTCAGGACATGGAGACTGTGGAAAGTTGTTAT
TTAAATAAATAAAAAGAAATGTTATAACTGTG

>5701_5701_16_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRDCNIIRILTSQFTNYQH

--------------------------------------------------------------
>5701_5701_17_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2326nt_BP=862nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT
GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT
GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG
ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG
TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCT
CCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCC
ATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATG
GTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATA
TATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATAT
GTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGG
CCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCA
TGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACC
AGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCAC
CTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATA
CCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAA
ATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGA
AGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTG
ATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATT
CAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAA
GACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAA

>5701_5701_17_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE
KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI
LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL
KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP
QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA
KSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_18_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5672nt_BP=862nt
GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG
AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG
GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG
GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT
CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA
ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC
CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT
GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT
GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG
ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGG
TGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAAC
AGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGA
ATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCAC
CAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCC
TTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGA
TTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACC
TTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGT
GCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGA
GAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTG
AAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAA
GGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATT
ATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTAT
ACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGA
GATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCT
CATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATC
TAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCC
ATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAA
AGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTATAGGTCTC
AGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTCATATATTATTACGT
GTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTT
AACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTG
TCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAG
CTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCC
CAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCT
CCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCA
AAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGTTCTTTTT
GTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTA
TTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGT
GCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATATCT
ACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATG
CATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACT
TCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCC
ATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGT
TATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATTTGTTTTG
GGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCATTCTTAATTGCATCACAC
AATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGTATCATTTATATTTGCCTTATGTTAACT
TTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTATTT
TTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTG
ACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTG
AAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAA
TTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAA
GTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAA
ACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTGCACTTCTATAAATAGTA
TGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAAC
AGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTT
ATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTT
GCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTG
AGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCT
TTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTT
TGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCA
CCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAATAGAAATTTTATTT
CCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTAT
ATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAATATGATATAATAAAGAAAAACTCCATTTATCATCTGT
TA

>5701_5701_18_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH
VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL
SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL
GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN
YRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_19_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1408nt_BP=528nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG
CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT
CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT
GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA
TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCAT
CAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGA
AAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGA
AAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAG
TTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAATTTTAACCTCTCAATTTACTAACTA
CCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAACTCT
TTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACTTTTAATAACTTTTCACCCAAACCAT
GCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAGACT
GCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTTTTA
AATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTCAGG
ACATGGAGACTGTGGAAAGTTGTTATTTAAATAAATAAAAAGAAATGTTATAACTGTG

>5701_5701_19_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=291AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV
ISGRDCNIIRILTSQFTNYQH

--------------------------------------------------------------
>5701_5701_20_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=1992nt_BP=528nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG
CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT
CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT
GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA
TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCAT
CAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATCTGA
TGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGA
TTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTT
TGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAG
ATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCA
TGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATAT
GCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCC
TGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCT
CAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAA
AGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGT
TGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTT
AGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAA
CCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAAC
TTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAA
CTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGA
CTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACA
ATAAACAGAAAA

>5701_5701_20_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=649AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATI
KDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNP
VTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
SHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_21_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5338nt_BP=528nt
CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA
GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG
CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT
CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT
GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA
TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCAT
CAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGA
AAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGA
AAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAG
TTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTAT
TCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATAC
CCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAG
GGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTT
AAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGC
CTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGA
TCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCC
ACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGT
ATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCAC
TTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGC
CAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGG
AAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAAT
AGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGC
ATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAG
GGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCAT
AATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTAC
ATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTAT
AGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATATCCC
TCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCTCCC
GGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAG
TGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTA
CAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTA
AATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGA
TATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATT
CCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATAG
AAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGAAAAATTGAAAA
ACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTTCTCTATACCTATATATGTATA
GATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACA
GACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATA
ATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCA
ATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAATTCT
ATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTT
TTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGTA
TCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCTATT
TTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAACTCAAATGTCATGATAGCTTG
CATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGG
GCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTAT
GTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAA
AGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGA
CCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATT
TAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACCT
TTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAGGCA
ATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCTTGA
CAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAGATTTTACTGATATGTAAAAATTTTG
CCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATA
ATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAA
AATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAAC
TCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCT
TCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGTA
GAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAATATGATATAAT
AAAGAAAAACTCCATTTATCATCTGTTA

>5701_5701_21_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=634AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV
ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK
YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERV
PFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV
DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIK
ILAQ

--------------------------------------------------------------
>5701_5701_22_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1793nt_BP=913nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT
GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC
TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA
CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT
GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT
ATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATA
TCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGG
TGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGT
CAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGACTGCAATATTATAAGAA
TTTTAACCTCTCAATTTACTAACTACCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAGTTTGGAAAACAGGAGA
ATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCTAGATTTATAATGAACT
TTTAATAACTTTTCACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATACTGTAGTATTTTCTAT
TTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGGAGTACCTAATTTTAGA
TTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGGTGTTGTCTATCTTAAT
TCTTTTAGGAATAAAACAATTCAGGACATGGAGACTGTGGAAAGTTGTTATTTAAATAAATAAAAAGAAATGTTATAACTGTG

>5701_5701_22_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=351AA_BP=224
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQIL
SGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRDCNIIRILTSQFTNYQH

--------------------------------------------------------------
>5701_5701_23_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2377nt_BP=913nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT
GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC
TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA
CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT
GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT
ATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATA
TCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAAGAAAGTCGGCGTCTGT
TCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCAC
ACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATG
CTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTG
GAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTT
CTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAAC
AGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGT
TTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATA
ACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCC
ATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAG
GTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAAT
TGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTAC
AGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTC
CACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTC
TTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTG
CAAATCTAATTAAAATTCTTGCACAATAAACAGAAAA

>5701_5701_23_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=709AA_BP=224
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTK
ELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS
SGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLD
ELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE
ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_24_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5723nt_BP=913nt
AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT
GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC
AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG
ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT
TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG
AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT
GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC
TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA
CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT
GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT
ATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGAGAGCTATTTGATTATA
TCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGG
TGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGT
CAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGG
TAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGA
AGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGA
AGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTT
CAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAA
ATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAA
GCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCAC
GCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTC
GACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTAC
GAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTA
GTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGA
GTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAA
CTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAACTTTGCTT
ATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAATTATAACCGAGGGCTG
GCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATTAAGATCATTTTGTTGT
TCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTAC
ACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATT
TGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACA
GTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCT
CGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCCACCACA
CCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGACCGCGTGATCCACCACC
TCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCTGTAGTGTATGGTAAGT
CATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCAGATACTCTAGCACTAA
TTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCAT
ATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTA
TCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACA
TTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTG
TTTTCTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGCTTTTTT
CCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATGACATTCTCCTAAAAAT
CCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAACTCCAAATTTCTTTATA
GCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAACATTATTATTATTTTG
ATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAG
ATTTCTGATTTACACTGATATTTTTTTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAAT
TGGTATCGTGTATGATAATATTGTATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATT
GCAACAGAGCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAA
TGAACTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTCAAAAGA
AAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAGTTCCATTTAAATATGA
GTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGCAGCATAATGTTCCTGA
TGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAG
AAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGT
TACTGTGTTTTATTTTGAAAATATTTAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAA
GCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTAC
TAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATG
CAACCATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTATAACAG
ATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTGGGGCATATGGGAGCTT
AATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGATGCTTTTGTAGTTTTT
CAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTACATTGAATTAATGCTT
GGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTT
TTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAA
CATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTT
CCTTGATTTAGAAATATGATATAATAAAGAAAAACTCCATTTATCATCTGTTA

>5701_5701_24_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=694AA_BP=224
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQIL
SGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF
DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSE
EEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA
KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSG
SVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_25_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000296800_length(transcript)=1629nt_BP=749nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA
GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG
TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC
ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG
GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC
GGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGA
GAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTAT
TGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGT
CTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGAGAC
TGCAATATTATAAGAATTTTAACCTCTCAATTTACTAACTACCAGCATTGAGAACATGAAGATATTTGTACAGTGTCGCTTTTTGAATAG
TTTGGAAAACAGGAGAATTTAATATTTTTAAGAATAACTCTTTGTCCTTCACTATACTACTGAAATTGAAAACAGAAGCTGAAGTTTGCT
AGATTTATAATGAACTTTTAATAACTTTTCACCCAAACCATGCTTATTTGTGTGAATGTTTTGCATCTTGATTAACTCAATGCAGAAATA
CTGTAGTATTTTCTATTTTTATAAGCTTGTTGGCCTAGACTGCTCAAAGAAATGAGATTTGTGTAAAAATATGGCTGTGAGTAAGGCAGG
AGTACCTAATTTTAGATTTGTCAAGTTTCATCTTTTTTTTAAATATTAACTTAATGTCAAAAATTATTTAAAAAATTTTTAAAAAAATGG
TGTTGTCTATCTTAATTCTTTTAGGAATAAAACAATTCAGGACATGGAGACTGTGGAAAGTTGTTATTTAAATAAATAAAAAGAAATGTT
ATAACTGTG

>5701_5701_25_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=320AA_BP=193
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD
VWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKI
ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRDCNIIRILTSQFTNYQH

--------------------------------------------------------------
>5701_5701_26_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000354209_length(transcript)=2213nt_BP=749nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA
GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG
TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC
ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG
GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC
GGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGA
GAGCTATTTGATTATATCTGTAAGAATGGAAGGAAATCTGATGTACCTGGAGTAGTAAAAACAGGCTCCACGAAGGAGCTGGATGAAAAA
GAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTATTGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAAT
GTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGTCTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGT
GGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTGTATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTC
TATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTGCCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCT
CAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTGCAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAA
CATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAGGATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAA
GAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTAC
CATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCAT
CACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAG
AAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGT
AGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTAC
TCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTATCTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAA
TCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTATCGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAA
TCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCTTCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAA
TTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAAACAGAAAA

>5701_5701_26_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=678AA_BP=193
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD
VWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDL
KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI
FYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPL
AVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIM
AEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAE
AQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------
>5701_5701_27_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000397128_length(transcript)=5559nt_BP=749nt
GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT
GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA
CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC
TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA
GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG
TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC
ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG
GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC
GGAGCAGACACAGACTATGCAGATGGGAGGTACCAGGTCATCAGTACACCATCTGATATTTTCATGGTGATGGAATATGTCTCAGGAGGA
GAGCTATTTGATTATATCTGTAAGAATGGAAGGCTGGATGAAAAAGAAAGTCGGCGTCTGTTCCAACAGATCCTTTCTGGTGTGGATTAT
TGTCACAGGCATATGGTGGTCCATAGAGATTTGAAACCTGAAAATGTCCTGCTTGATGCACACATGAATGCAAAGATAGCTGATTTTGGT
CTTTCAAACATGATGTCAGATGGTGAATTTTTAAGAACAAGTTGTGGCTCACCCAACTATGCTGCACCAGAAGTAATTTCAGGAAGATTG
TATGCAGGCCCAGAGGTAGATATATGGAGCAGTGGGGTTATTCTCTATGCTTTATTATGTGGAACCCTTCCATTTGATGATGACCATGTG
CCAACTCTTTTTAAGAAGATATGTGATGGGATCTTCTATACCCCTCAATATTTAAATCCTTCTGTGATTAGCCTTTTGAAACATATGCTG
CAGGTGGATCCCATGAAGAGGGCCACAATCAAAGATATCAGGGAACATGAATGGTTTAAACAGGACCTTCCAAAATATCTCTTTCCTGAG
GATCCATCATATAGTTCAACCATGATTGATGATGAAGCCTTAAAAGAAGTATGTGAAAAGTTTGAGTGCTCAGAAGAGGAAGTTCTCAGC
TGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGAT
TTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCT
GAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGA
ATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCA
TATTATTTGCGTGTACGAAGGAAGAATCCTGTGACAAGCACTTACTCCAAAATGAGTCTACAGTTATACCAAGTGGATAGTAGAACTTAT
CTACTGGATTTCCGTAGTATTGATGATGAAATTACAGAAGCCAAATCAGGGACTGCTACTCCACAGAGATCGGGATCAGTTAGCAACTAT
CGATCTTGCCAAAGGAGTGATTCAGATGCTGAGGCTCAAGGAAAATCCTCAGAAGTTTCTCTTACCTCATCTGTGACCTCACTTGACTCT
TCTCCTGTTGACCTAACTCCAAGACCTGGAAGTCACACAATAGAATTTTTTGAGATGTGTGCAAATCTAATTAAAATTCTTGCACAATAA
ACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAGTTATACATAA
TTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAAAGCCTAATATGCAGAAATGAATT
AAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTATAGGTCTCAGGCTTACTTGATTTTTGGCTAT
TTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCCTTCATATATTATTACGTGTTATATATTACGTGTTATAAAT
TTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTATAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCT
TCCAGCAGTAGTAACAGTCTGGATAACTTCTTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAG
TGCAATGGTGTGGTCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACA
GGCGTGTGCCACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGAC
CGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTTTTAAAATTCT
GTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCAAAAACACAGAATTTATATATTCA
GATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGTTCTTTTTGTTACAAGAGCTGAGTTGCATAT
ACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCCCATCATGTCAGTCATTATTGAGTATATGCACACATTGCTA
CTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATAGAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCA
AATTTTATTATGAACATTTTTAAAAACAGAAAAATTGAAAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTT
AATGTTTTGTCATTTGTTTTCTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTAT
GTATATATGCTTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATG
ACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTCTGAAGTTAAC
TCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGTTATAACTCTTTAGTTGGATATAA
CATTATTATTATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATTTGTTTTGGGCTTAAATTACTTTTTAAAGAT
ACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCATTCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAG
TCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGTATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTAT
TAATCATTTTCCCATTGCAACAGAGCTATATTTTTTCTATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTA
TGTAACCAGATGATAATGAACTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATG
CACTGAATTCAAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAG
TTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGTCTCTAAGTGC
AGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAAGTAATGGCGCTATATACGCTGTT
GTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAATTTTGTAAACTTTGCTTCTCTTATAAGTTAT
TGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTGCACTTCTATAAATAGTATGATAAATGCACAGACAATTGCA
GTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACCTTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTT
GTTTGCAAATTGTTACTAATATTGAAGAGGTAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATAT
TTTTTGTGACTTTATGCAACCATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATA
GTTTTAAGTATAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTG
GGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTTTTTCTTGAGA
TGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTTTGATGTTGTAGTGACACCATTTA
CATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTGACTGGCACCTTTGGAATGAAAGAAAAGTGT
GTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCATAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAAT
GAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGTAGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAG
TATATAATTTCAGCTTCCTTGATTTAGAAATATGATATAATAAAGAAAAACTCCATTTATCATCTGTTA

>5701_5701_27_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=663AA_BP=193
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD
VWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKI
ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLL
KHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMN
EAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWK
VVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVT
SLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for APP-PRKAA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518732_751220.66666666666666771.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516732_751220.66666666666666696.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415732_751164.66666666666666640.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517732_751220.66666666666666752.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517732_751220.66666666666666753.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517732_751220.66666666666666715.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517732_751215.66666666666666747.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518695_722220.66666666666666771.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516695_722220.66666666666666696.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415695_722164.66666666666666640.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517695_722220.66666666666666752.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517695_722220.66666666666666753.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517695_722220.66666666666666715.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517695_722215.66666666666666747.0PSEN1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APP-PRKAA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APP-PRKAA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPPC0002395Alzheimer's Disease63CTD_human;UNIPROT
HgeneAPPC0011265Presenile dementia35CTD_human
HgeneAPPC0276496Familial Alzheimer Disease (FAD)35CTD_human
HgeneAPPC0494463Alzheimer Disease, Late Onset35CTD_human
HgeneAPPC0546126Acute Confusional Senile Dementia35CTD_human
HgeneAPPC0750900Alzheimer's Disease, Focal Onset35CTD_human
HgeneAPPC0750901Alzheimer Disease, Early Onset35CTD_human
HgeneAPPC0025261Memory Disorders16CTD_human
HgeneAPPC0233794Memory impairment16CTD_human
HgeneAPPC0751292Age-Related Memory Disorders16CTD_human
HgeneAPPC0751293Memory Disorder, Semantic16CTD_human
HgeneAPPC0751294Memory Disorder, Spatial16CTD_human
HgeneAPPC0751295Memory Loss16CTD_human
HgeneAPPC0027746Nerve Degeneration11CTD_human
HgeneAPPC0023186Learning Disorders8CTD_human
HgeneAPPC0751262Adult Learning Disorders8CTD_human
HgeneAPPC0751263Learning Disturbance8CTD_human
HgeneAPPC0751265Learning Disabilities8CTD_human
HgeneAPPC1330966Developmental Academic Disorder8CTD_human
HgeneAPPC2751536CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED7CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAPPC0009241Cognition Disorders5CTD_human
HgeneAPPC0011570Mental Depression5PSYGENET
HgeneAPPC0011581Depressive disorder5PSYGENET
HgeneAPPC0234544Todd Paralysis5CTD_human
HgeneAPPC0522224Paralysed5CTD_human
HgeneAPPC0497327Dementia3CTD_human;GENOMICS_ENGLAND
HgeneAPPC2931672Cerebral hemorrhage with amyloidosis, hereditary, Dutch type3CTD_human;ORPHANET
HgeneAPPC0270715Degenerative Diseases, Central Nervous System2CTD_human
HgeneAPPC0333463Senile Plaques2CTD_human
HgeneAPPC0524851Neurodegenerative Disorders2CTD_human
HgeneAPPC0600467Neurogenic Inflammation2CTD_human
HgeneAPPC0751733Degenerative Diseases, Spinal Cord2CTD_human
HgeneAPPC2751494CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ARCTIC VARIANT2CTD_human
HgeneAPPC2936349Plaque, Amyloid2CTD_human
HgeneAPPC3888307CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, FLEMISH VARIANT2CTD_human
HgeneAPPC3888308CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ITALIAN VARIANT2CTD_human
HgeneAPPC3888309CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, IOWA VARIANT2CTD_human
HgeneAPPC0002622Amnesia1CTD_human
HgeneAPPC0002726Amyloidosis1CTD_human
HgeneAPPC0003469Anxiety Disorders1CTD_human
HgeneAPPC0005586Bipolar Disorder1PSYGENET
HgeneAPPC0006111Brain Diseases1CTD_human
HgeneAPPC0011573Endogenous depression1PSYGENET
HgeneAPPC0016667Fragile X Syndrome1CTD_human
HgeneAPPC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneAPPC0027540Necrosis1CTD_human
HgeneAPPC0033141Cardiomyopathies, Primary1CTD_human
HgeneAPPC0036529Myocardial Diseases, Secondary1CTD_human
HgeneAPPC0036572Seizures1GENOMICS_ENGLAND
HgeneAPPC0037928Spinal Cord Diseases1CTD_human
HgeneAPPC0038002Splenomegaly1CTD_human
HgeneAPPC0038454Cerebrovascular accident1GENOMICS_ENGLAND
HgeneAPPC0043094Weight Gain1CTD_human
HgeneAPPC0085220Cerebral Amyloid Angiopathy1CTD_human
HgeneAPPC0085584Encephalopathies1CTD_human
HgeneAPPC0231341Premature aging syndrome1CTD_human
HgeneAPPC0233750Hysterical amnesia1CTD_human
HgeneAPPC0233796Temporary Amnesia1CTD_human
HgeneAPPC0234985Mental deterioration1CTD_human
HgeneAPPC0236795Dissociative Amnesia1CTD_human
HgeneAPPC0262497Global Amnesia1CTD_human
HgeneAPPC0270612Leukoencephalopathy1GENOMICS_ENGLAND
HgeneAPPC0338582Sporadic Cerebral Amyloid Angiopathy1CTD_human
HgeneAPPC0338630Senile Paranoid Dementia1CTD_human
HgeneAPPC0338656Impaired cognition1CTD_human
HgeneAPPC0376280Anxiety States, Neurotic1CTD_human
HgeneAPPC0553692Brain hemorrhage1GENOMICS_ENGLAND
HgeneAPPC0750906Tactile Amnesia1CTD_human
HgeneAPPC0750907Amnestic State1CTD_human
HgeneAPPC0751071Familial Dementia1CTD_human
HgeneAPPC0751156FRAXA Syndrome1CTD_human
HgeneAPPC0751157FRAXE Syndrome1CTD_human
HgeneAPPC0878544Cardiomyopathies1CTD_human
HgeneAPPC0948008Ischemic stroke1GENOMICS_ENGLAND
HgeneAPPC1270972Mild cognitive disorder1CTD_human
HgeneAPPC1279420Anxiety neurosis (finding)1CTD_human
TgeneC0021655Insulin Resistance1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0032927Precancerous Conditions1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0079487Helicobacter Infections1CTD_human
TgeneC0271650Impaired glucose tolerance1CTD_human
TgeneC0282313Condition, Preneoplastic1CTD_human
TgeneC0920563Insulin Sensitivity1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human