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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APRT-EFCAB6 (FusionGDB2 ID:HG353TG64800)

Fusion Gene Summary for APRT-EFCAB6

check button Fusion gene summary
Fusion gene informationFusion gene name: APRT-EFCAB6
Fusion gene ID: hg353tg64800
HgeneTgene
Gene symbol

APRT

EFCAB6

Gene ID

353

64800

Gene nameadenine phosphoribosyltransferaseEF-hand calcium binding domain 6
SynonymsAMP|APRTDDJBP|HSCBCIP1|dJ185D5.1
Cytomap('APRT')('EFCAB6')

16q24.3

22q13.2-q13.31

Type of geneprotein-codingprotein-coding
Descriptionadenine phosphoribosyltransferaseAMP diphosphorylaseAMP pyrophosphorylasetransphosphoribosidaseEF-hand calcium-binding domain-containing protein 6CAP-binding protein complex-interacting protein 1DJ-1-binding proteinepididymis secretory sperm binding protein
Modification date2020032220200313
UniProtAcc

P07741

.
Ensembl transtripts involved in fusion geneENST00000426324, ENST00000563655, 
ENST00000378364, 
Fusion gene scores* DoF score2 X 2 X 1=429 X 21 X 6=3654
# samples 231
** MAII scorelog2(2/4*10)=2.32192809488736log2(31/3654*10)=-3.55913651335325
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APRT [Title/Abstract] AND EFCAB6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPRT(88875877)-EFCAB6(43944420), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for APRT-EFCAB6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for APRT-EFCAB6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for APRT-EFCAB6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:88875877/:43944420)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APRT

P07741

.
FUNCTION: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for APRT-EFCAB6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for APRT-EFCAB6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APRT-EFCAB6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneAPRTP07741DB016325-O-phosphono-alpha-D-ribofuranosyl diphosphateSmall moleculeApproved|Experimental|Investigational
HgeneAPRTP07741DB00173AdenineSmall moleculeApproved|Nutraceutical
HgeneAPRTP07741DB04272Citric acidSmall moleculeApproved|Nutraceutical|Vet_approved

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Related Diseases for APRT-EFCAB6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPRTC0268120Adenine phosphoribosyltransferase deficiency11CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneAPRTC0011570Mental Depression5PSYGENET
HgeneAPRTC0011581Depressive disorder5PSYGENET
HgeneAPRTC0451641Urolithiasis2CTD_human
HgeneAPRTC0006142Malignant neoplasm of breast1CTD_human
HgeneAPRTC0007134Renal Cell Carcinoma1CTD_human
HgeneAPRTC0022661Kidney Failure, Chronic1GENOMICS_ENGLAND
HgeneAPRTC0027707Nephritis, Interstitial1GENOMICS_ENGLAND
HgeneAPRTC0041696Unipolar Depression1PSYGENET
HgeneAPRTC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneAPRTC0678222Breast Carcinoma1CTD_human
HgeneAPRTC1257931Mammary Neoplasms, Human1CTD_human
HgeneAPRTC1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneAPRTC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneAPRTC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneAPRTC1269683Major Depressive Disorder1PSYGENET
HgeneAPRTC1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneAPRTC1458155Mammary Neoplasms1CTD_human
HgeneAPRTC1561643Chronic Kidney Diseases1GENOMICS_ENGLAND
HgeneAPRTC36653822,8-Dihydroxyadenine Urolithiasis1CTD_human;ORPHANET
HgeneAPRTC4704874Mammary Carcinoma, Human1CTD_human