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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:AR-NR4A3 (FusionGDB2 ID:HG367TG8013) |
Fusion Gene Summary for AR-NR4A3 |
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Fusion gene information | Fusion gene name: AR-NR4A3 | Fusion gene ID: hg367tg8013 | Hgene | Tgene | Gene symbol | AR | NR4A3 | Gene ID | 367 | 8013 |
Gene name | androgen receptor | nuclear receptor subfamily 4 group A member 3 | |
Synonyms | AIS|AR8|DHTR|HUMARA|HYSP1|KD|NR3C4|SBMA|SMAX1|TFM | CHN|CSMF|MINOR|NOR1|TEC | |
Cytomap | ('AR')('NR4A3') Xq12 | 9q31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | androgen receptordihydrotestosterone receptornuclear receptor subfamily 3 group C member 4 | nuclear receptor subfamily 4 group A member 3chondrosarcoma, extraskeletal myxoid, fused to EWSmitogen-induced nuclear orphan receptorneuron-derived orphan receptor 1nuclear hormone receptor NOR-1translocated in extraskeletal chondrosarcoma | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000513847, ENST00000374690, ENST00000396043, ENST00000396044, ENST00000504326, | ||
Fusion gene scores | * DoF score | 4 X 5 X 4=80 | 9 X 11 X 7=693 |
# samples | 5 | 11 | |
** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/693*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AR [Title/Abstract] AND NR4A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | AR(66863249)-NR4A3(102587941), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AR | GO:0006351 | transcription, DNA-templated | 15572661 |
Hgene | AR | GO:0008284 | positive regulation of cell proliferation | 17277772 |
Hgene | AR | GO:0010628 | positive regulation of gene expression | 24681825 |
Hgene | AR | GO:0030521 | androgen receptor signaling pathway | 19886863|20048160 |
Hgene | AR | GO:0030522 | intracellular receptor signaling pathway | 17277772 |
Hgene | AR | GO:0045720 | negative regulation of integrin biosynthetic process | 21310825 |
Hgene | AR | GO:0045726 | positive regulation of integrin biosynthetic process | 21310825 |
Hgene | AR | GO:0045893 | positive regulation of transcription, DNA-templated | 11477070|12799378 |
Hgene | AR | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12799378|16728402|17505061|20048160|20181722 |
Hgene | AR | GO:0045945 | positive regulation of transcription by RNA polymerase III | 18487222 |
Hgene | AR | GO:1903076 | regulation of protein localization to plasma membrane | 21310825 |
Hgene | AR | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 21310825 |
Tgene | NR4A3 | GO:0010828 | positive regulation of glucose transmembrane transport | 24022864 |
Tgene | NR4A3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20558821 |
Tgene | NR4A3 | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 23554459 |
Tgene | NR4A3 | GO:0048660 | regulation of smooth muscle cell proliferation | 25852083 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LIHC | TCGA-G3-A7M8-01A | AR | chrX | 66863249 | - | NR4A3 | chr9 | 102587941 | + |
ChimerDB4 | LIHC | TCGA-G3-A7M8-01A | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
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Fusion Gene ORF analysis for AR-NR4A3 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000513847 | ENST00000338488 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
3UTR-5UTR | ENST00000513847 | ENST00000395097 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
3UTR-intron | ENST00000513847 | ENST00000330847 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-5UTR | ENST00000374690 | ENST00000338488 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-5UTR | ENST00000374690 | ENST00000395097 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-5UTR | ENST00000396043 | ENST00000338488 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-5UTR | ENST00000396043 | ENST00000395097 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-5UTR | ENST00000396044 | ENST00000338488 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-5UTR | ENST00000396044 | ENST00000395097 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-5UTR | ENST00000504326 | ENST00000338488 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-5UTR | ENST00000504326 | ENST00000395097 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-intron | ENST00000374690 | ENST00000330847 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-intron | ENST00000396043 | ENST00000330847 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-intron | ENST00000396044 | ENST00000330847 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
5CDS-intron | ENST00000504326 | ENST00000330847 | AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587941 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for AR-NR4A3 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587940 | + | 0.000230349 | 0.9997696 |
AR | chrX | 66863249 | + | NR4A3 | chr9 | 102587940 | + | 0.000230349 | 0.9997696 |
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Fusion Protein Features for AR-NR4A3 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:66863249/:102587941) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for AR-NR4A3 |
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Fusion Gene PPI Analysis for AR-NR4A3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AR-NR4A3 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AR-NR4A3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AR | C0039585 | Androgen-Insensitivity Syndrome | 74 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | AR | C0268301 | Reifenstein Syndrome | 41 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | AR | C0033578 | Prostatic Neoplasms | 21 | CTD_human |
Hgene | AR | C0376358 | Malignant neoplasm of prostate | 21 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | AR | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | AR | C0011581 | Depressive disorder | 5 | PSYGENET |
Hgene | AR | C3658266 | Prostatic Cancer, Castration-Resistant | 4 | CTD_human |
Hgene | AR | C3658267 | Prostatic Neoplasms, Castration-Resistant | 4 | CTD_human |
Hgene | AR | C0021364 | Male infertility | 3 | CTD_human |
Hgene | AR | C0236663 | Alcohol withdrawal syndrome | 3 | PSYGENET |
Hgene | AR | C0848676 | Subfertility, Male | 3 | CTD_human |
Hgene | AR | C0917731 | Male sterility | 3 | CTD_human |
Hgene | AR | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Hgene | AR | C0006142 | Malignant neoplasm of breast | 2 | CTD_human;UNIPROT |
Hgene | AR | C0238033 | Carcinoma of Male Breast | 2 | CTD_human |
Hgene | AR | C0242788 | Breast Neoplasms, Male | 2 | CTD_human |
Hgene | AR | C0678222 | Breast Carcinoma | 2 | CTD_human |
Hgene | AR | C0936016 | Testicular Feminization | 2 | CTD_human |
Hgene | AR | C1257931 | Mammary Neoplasms, Human | 2 | CTD_human |
Hgene | AR | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Hgene | AR | C2713546 | Androgen Receptor Deficiency | 2 | CTD_human |
Hgene | AR | C4704874 | Mammary Carcinoma, Human | 2 | CTD_human |
Hgene | AR | C0002170 | Alopecia | 1 | CTD_human |
Hgene | AR | C0004114 | Astrocytoma | 1 | CTD_human |
Hgene | AR | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | AR | C0017412 | Genital Diseases, Male | 1 | CTD_human |
Hgene | AR | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | AR | C0021361 | Female infertility | 1 | CTD_human |
Hgene | AR | C0021655 | Insulin Resistance | 1 | CTD_human |
Hgene | AR | C0023418 | leukemia | 1 | CTD_human |
Hgene | AR | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Hgene | AR | C0038279 | Sterility, Postpartum | 1 | CTD_human |
Hgene | AR | C0085207 | Gestational Diabetes | 1 | CTD_human |
Hgene | AR | C0086873 | Pseudopelade | 1 | CTD_human |
Hgene | AR | C0162311 | Androgenetic Alopecia | 1 | CTD_human |
Hgene | AR | C0205768 | Subependymal Giant Cell Astrocytoma | 1 | CTD_human |
Hgene | AR | C0263477 | Female pattern alopecia (disorder) | 1 | CTD_human |
Hgene | AR | C0280783 | Juvenile Pilocytic Astrocytoma | 1 | CTD_human |
Hgene | AR | C0280785 | Diffuse Astrocytoma | 1 | CTD_human |
Hgene | AR | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
Hgene | AR | C0334579 | Anaplastic astrocytoma | 1 | CTD_human |
Hgene | AR | C0334580 | Protoplasmic astrocytoma | 1 | CTD_human |
Hgene | AR | C0334581 | Gemistocytic astrocytoma | 1 | CTD_human |
Hgene | AR | C0334582 | Fibrillary Astrocytoma | 1 | CTD_human |
Hgene | AR | C0334583 | Pilocytic Astrocytoma | 1 | CTD_human |
Hgene | AR | C0338070 | Childhood Cerebral Astrocytoma | 1 | CTD_human |
Hgene | AR | C0341869 | Subfertility, Female | 1 | CTD_human |
Hgene | AR | C0525045 | Mood Disorders | 1 | PSYGENET |
Hgene | AR | C0547065 | Mixed oligoastrocytoma | 1 | CTD_human |
Hgene | AR | C0556385 | Craving for alcohol | 1 | PSYGENET |
Hgene | AR | C0750935 | Cerebral Astrocytoma | 1 | CTD_human |
Hgene | AR | C0750936 | Intracranial Astrocytoma | 1 | CTD_human |
Hgene | AR | C0917730 | Female sterility | 1 | CTD_human |
Hgene | AR | C0920563 | Insulin Sensitivity | 1 | CTD_human |
Hgene | AR | C1704230 | Grade I Astrocytoma | 1 | CTD_human |
Hgene | AR | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | AR | C4083212 | Alopecia, Male Pattern | 1 | CTD_human |
Tgene | C0003873 | Rheumatoid Arthritis | 1 | CTD_human | |
Tgene | C0020443 | Hypercholesterolemia | 1 | CTD_human | |
Tgene | C0021655 | Insulin Resistance | 1 | CTD_human | |
Tgene | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human | |
Tgene | C0920563 | Insulin Sensitivity | 1 | CTD_human | |
Tgene | C1275278 | Extraskeletal Myxoid Chondrosarcoma | 1 | CTD_human;ORPHANET | |
Tgene | C3495559 | Juvenile arthritis | 1 | CTD_human | |
Tgene | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human | |
Tgene | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human | |
Tgene | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |