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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITGB2-SUMO3 (FusionGDB2 ID:HG3689TG6612)

Fusion Gene Summary for ITGB2-SUMO3

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB2-SUMO3
Fusion gene ID: hg3689tg6612
HgeneTgene
Gene symbol

ITGB2

SUMO3

Gene ID

3689

6612

Gene nameintegrin subunit beta 2small ubiquitin like modifier 3
SynonymsCD18|LAD|LCAMB|LFA-1|MAC-1|MF17|MFI7SMT3A|SMT3H1|SUMO-3|Smt3B
Cytomap('ITGB2')('SUMO3')

21q22.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-2cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)complement component 3 receptor 3 and 4 subunitcomplement receptor C3 beta-subunitintegrin beta chain, beta 2integrin, beta 2 (complement component 3 receptosmall ubiquitin-related modifier 3SMT3 suppressor of mif two 3 homolog 1SMT3 suppressor of mif two 3 homolog 3ubiquitin-like protein SMT3B
Modification date2020032220200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000302347, ENST00000397846, 
ENST00000397850, ENST00000397854, 
ENST00000355153, ENST00000397852, 
ENST00000397857, ENST00000523126, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 6 X 3=108
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGB2 [Title/Abstract] AND SUMO3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGB2(46340736)-SUMO3(46234019), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGB2

GO:0007155

cell adhesion

19703720

HgeneITGB2

GO:0007159

leukocyte cell-cell adhesion

12885943

HgeneITGB2

GO:0030593

neutrophil chemotaxis

12885943

HgeneITGB2

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

12885943

TgeneSUMO3

GO:0016925

protein sumoylation

11889051|16626738|17696781|21965678|24105744

TgeneSUMO3

GO:0043392

negative regulation of DNA binding

16626738



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315333ITGB2chr21

46340736

-SUMO3chr21

46234019

-
ChimerDB4Non-CancerERR315395ITGB2chr21

46340736

-SUMO3chr21

46234019

-
ChimerDB4Non-CancerERR315396ITGB2chr21

46340736

-SUMO3chr21

46234019

-
ChimerDB4Non-CancerERR315404ITGB2chr21

46340736

-SUMO3chr21

46234019

-
ChimerDB4Non-CancerERR315469ITGB2chr21

46340736

-SUMO3chr21

46234019

-


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Fusion Gene ORF analysis for ITGB2-SUMO3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000302347ENST00000332859ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-3CDSENST00000302347ENST00000397898ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-3CDSENST00000397846ENST00000332859ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-3CDSENST00000397846ENST00000397898ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-3CDSENST00000397850ENST00000332859ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-3CDSENST00000397850ENST00000397898ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-3CDSENST00000397854ENST00000332859ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-3CDSENST00000397854ENST00000397898ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000302347ENST00000397893ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000302347ENST00000411651ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000302347ENST00000479153ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000397846ENST00000397893ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000397846ENST00000411651ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000397846ENST00000479153ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000397850ENST00000397893ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000397850ENST00000411651ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000397850ENST00000479153ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000397854ENST00000397893ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000397854ENST00000411651ITGB2chr21

46340736

-SUMO3chr21

46234019

-
5UTR-5UTRENST00000397854ENST00000479153ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-3CDSENST00000355153ENST00000332859ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-3CDSENST00000355153ENST00000397898ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-3CDSENST00000397852ENST00000332859ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-3CDSENST00000397852ENST00000397898ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-3CDSENST00000397857ENST00000332859ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-3CDSENST00000397857ENST00000397898ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-3CDSENST00000523126ENST00000332859ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-3CDSENST00000523126ENST00000397898ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000355153ENST00000397893ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000355153ENST00000411651ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000355153ENST00000479153ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000397852ENST00000397893ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000397852ENST00000411651ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000397852ENST00000479153ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000397857ENST00000397893ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000397857ENST00000411651ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000397857ENST00000479153ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000523126ENST00000397893ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000523126ENST00000411651ITGB2chr21

46340736

-SUMO3chr21

46234019

-
intron-5UTRENST00000523126ENST00000479153ITGB2chr21

46340736

-SUMO3chr21

46234019

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ITGB2-SUMO3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ITGB2-SUMO3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46340736/:46234019)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ITGB2-SUMO3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ITGB2-SUMO3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITGB2-SUMO3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITGB2-SUMO3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGB2C0398738Leukocyte adhesion deficiency type 112CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneITGB2C0023510Leukocyte Disorders2CTD_human
HgeneITGB2C0004943Behcet Syndrome1CTD_human
HgeneITGB2C0006118Brain Neoplasms1CTD_human
HgeneITGB2C0006663Calcinosis1CTD_human
HgeneITGB2C0011603Dermatitis1CTD_human
HgeneITGB2C0018824Heart valve disease1CTD_human
HgeneITGB2C0020517Hypersensitivity1CTD_human
HgeneITGB2C0023487Acute Promyelocytic Leukemia1CTD_human
HgeneITGB2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneITGB2C0027720Nephrosis1CTD_human
HgeneITGB2C0032285Pneumonia1CTD_human
HgeneITGB2C0032300Lobar Pneumonia1CTD_human
HgeneITGB2C0037299Skin Ulcer1CTD_human
HgeneITGB2C0153633Malignant neoplasm of brain1CTD_human
HgeneITGB2C0242597Leukocyte-Adhesion Deficiency Syndrome1CTD_human
HgeneITGB2C0263454Chloracne1CTD_human
HgeneITGB2C0263628Tumoral calcinosis1CTD_human
HgeneITGB2C0496899Benign neoplasm of brain, unspecified1CTD_human
HgeneITGB2C0521174Microcalcification1CTD_human
HgeneITGB2C0750974Brain Tumor, Primary1CTD_human
HgeneITGB2C0750977Recurrent Brain Neoplasm1CTD_human
HgeneITGB2C0750979Primary malignant neoplasm of brain1CTD_human
HgeneITGB2C0887898Experimental Lung Inflammation1CTD_human
HgeneITGB2C1527304Allergic Reaction1CTD_human
HgeneITGB2C1527390Neoplasms, Intracranial1CTD_human
HgeneITGB2C3714636Pneumonitis1CTD_human