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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCC6-C16orf70 (FusionGDB2 ID:HG368TG80262)

Fusion Gene Summary for ABCC6-C16orf70

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC6-C16orf70
Fusion gene ID: hg368tg80262
HgeneTgene
Gene symbol

ABCC6

C16orf70

Gene ID

368

80262

Gene nameATP binding cassette subfamily C member 6chromosome 16 open reading frame 70
SynonymsABC34|ARA|EST349056|GACI2|MLP1|MOAT-E|MOATE|MRP6|PXE|PXE1|URG7C16orf6|LIN10|lin-10
Cytomap('ABCC6')('C16orf70')

16p13.11

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 6URG7 proteinATP-binding cassette, sub-family C (CFTR/MRP), member 6anthracycline resistance-associated proteinmulti-specific organic anion transporter EUPF0183 protein C16orf70lin-10 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000205557, ENST00000574094, 
ENST00000575728, 
Fusion gene scores* DoF score5 X 5 X 3=757 X 7 X 6=294
# samples 58
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/294*10)=-1.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCC6 [Title/Abstract] AND C16orf70 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCC6(16253339)-C16orf70(67165189), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCC6-C16orf70 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC6-C16orf70 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC6-C16orf70 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC6-C16orf70 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ABCC6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C16orf70 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2846-03AABCC6chr16

16253339

-C16orf70chr16

67165189

+


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Fusion Gene ORF analysis for ABCC6-C16orf70

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000205557ENST00000569683ABCC6chr16

16253339

-C16orf70chr16

67165189

+
In-frameENST00000205557ENST00000219139ABCC6chr16

16253339

-C16orf70chr16

67165189

+
In-frameENST00000205557ENST00000569600ABCC6chr16

16253339

-C16orf70chr16

67165189

+
intron-3CDSENST00000574094ENST00000219139ABCC6chr16

16253339

-C16orf70chr16

67165189

+
intron-3CDSENST00000574094ENST00000569600ABCC6chr16

16253339

-C16orf70chr16

67165189

+
intron-3CDSENST00000575728ENST00000219139ABCC6chr16

16253339

-C16orf70chr16

67165189

+
intron-3CDSENST00000575728ENST00000569600ABCC6chr16

16253339

-C16orf70chr16

67165189

+
intron-3UTRENST00000574094ENST00000569683ABCC6chr16

16253339

-C16orf70chr16

67165189

+
intron-3UTRENST00000575728ENST00000569683ABCC6chr16

16253339

-C16orf70chr16

67165189

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000205557ABCC6chr1616253339-ENST00000569600C16orf70chr1667165189+480337653048021590
ENST00000205557ABCC6chr1616253339-ENST00000219139C16orf70chr1667165189+621137653048021590

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000205557ENST00000569600ABCC6chr1616253339-C16orf70chr1667165189+0.0012991650.99870086
ENST00000205557ENST00000219139ABCC6chr1616253339-C16orf70chr1667165189+0.0009538950.99904615

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Fusion Genomic Features for ABCC6-C16orf70


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABCC6chr1616253338-C16orf70chr1667165188+9.23E-070.99999905
ABCC6chr1616253338-C16orf70chr1667165188+9.23E-070.99999905

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABCC6-C16orf70


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:16253339/chr16:67165189)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631311_59312451504.0DomainABC transmembrane type-1 1
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631629_85312451504.0DomainABC transporter 1
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631947_122812451504.0DomainABC transmembrane type-1 2
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631663_67012451504.0Nucleotide bindingATP 1
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311019_106112451504.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311083_108312451504.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311105_117512451504.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311197_119812451504.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631120_13112451504.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631150_16712451504.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631189_30212451504.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311_3112451504.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631324_34912451504.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631371_42612451504.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631448_45012451504.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631472_53312451504.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-263153_7212451504.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631555_57512451504.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631597_93912451504.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-263194_9812451504.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631961_99712451504.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311062_108212451504.0TransmembraneHelical%3B Name%3D14
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311084_110412451504.0TransmembraneHelical%3B Name%3D15
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311176_119612451504.0TransmembraneHelical%3B Name%3D16
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311199_121912451504.0TransmembraneHelical%3B Name%3D17
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631132_14912451504.0TransmembraneHelical%3B Name%3D4
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631168_18812451504.0TransmembraneHelical%3B Name%3D5
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631303_32312451504.0TransmembraneHelical%3B Name%3D6
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-263132_5212451504.0TransmembraneHelical%3B Name%3D1
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631350_37012451504.0TransmembraneHelical%3B Name%3D7
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631427_44712451504.0TransmembraneHelical%3B Name%3D8
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631451_47112451504.0TransmembraneHelical%3B Name%3D9
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631534_55412451504.0TransmembraneHelical%3B Name%3D10
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631576_59612451504.0TransmembraneHelical%3B Name%3D11
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-263173_9312451504.0TransmembraneHelical%3B Name%3D2
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631940_96012451504.0TransmembraneHelical%3B Name%3D12
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-2631998_101812451504.0TransmembraneHelical%3B Name%3D13
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-263199_11912451504.0TransmembraneHelical%3B Name%3D3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311265_149912451504.0DomainABC transporter 2
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121265_14990100.0DomainABC transporter 2
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12311_5930100.0DomainABC transmembrane type-1 1
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12629_8530100.0DomainABC transporter 1
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12947_12280100.0DomainABC transmembrane type-1 2
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311299_130612451504.0Nucleotide bindingATP 2
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121299_13060100.0Nucleotide bindingATP 2
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12663_6700100.0Nucleotide bindingATP 1
HgeneABCC6chr16:16253339chr16:67165189ENST00000205557-26311220_150312451504.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121019_10610100.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121083_10830100.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121105_11750100.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121197_11980100.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12120_1310100.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121220_15030100.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12150_1670100.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12189_3020100.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121_310100.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12324_3490100.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12371_4260100.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12448_4500100.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12472_5330100.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-1253_720100.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12555_5750100.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12597_9390100.0Topological domainCytoplasmic
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-1294_980100.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12961_9970100.0Topological domainExtracellular
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121062_10820100.0TransmembraneHelical%3B Name%3D14
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121084_11040100.0TransmembraneHelical%3B Name%3D15
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121176_11960100.0TransmembraneHelical%3B Name%3D16
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-121199_12190100.0TransmembraneHelical%3B Name%3D17
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12132_1490100.0TransmembraneHelical%3B Name%3D4
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12168_1880100.0TransmembraneHelical%3B Name%3D5
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12303_3230100.0TransmembraneHelical%3B Name%3D6
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-1232_520100.0TransmembraneHelical%3B Name%3D1
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12350_3700100.0TransmembraneHelical%3B Name%3D7
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12427_4470100.0TransmembraneHelical%3B Name%3D8
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12451_4710100.0TransmembraneHelical%3B Name%3D9
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12534_5540100.0TransmembraneHelical%3B Name%3D10
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12576_5960100.0TransmembraneHelical%3B Name%3D11
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-1273_930100.0TransmembraneHelical%3B Name%3D2
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12940_9600100.0TransmembraneHelical%3B Name%3D12
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-12998_10180100.0TransmembraneHelical%3B Name%3D13
HgeneABCC6chr16:16253339chr16:67165189ENST00000575728-1299_1190100.0TransmembraneHelical%3B Name%3D3


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Fusion Gene Sequence for ABCC6-C16orf70


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>311_311_1_ABCC6-C16orf70_ABCC6_chr16_16253339_ENST00000205557_C16orf70_chr16_67165189_ENST00000219139_length(transcript)=6211nt_BP=3765nt
CGCTGGGACCCACGACGACAGAAGGCGCCGATGGCCGCGCCTGCTGAGCCCTGCGCGGGGCAGGGGGTCTGGAACCAGACAGAGCCTGAA
CCTGCCGCCACCAGCCTGCTGAGCCTGTGCTTCCTGAGAACAGCAGGGGTCTGGGTACCCCCCATGTACCTCTGGGTCCTTGGTCCCATC
TACCTCCTCTTCATCCACCACCATGGCCGGGGCTACCTCCGGATGTCCCCACTCTTCAAAGCCAAGATGGTGCTTGGATTCGCCCTCATA
GTCCTGTGTACCTCCAGCGTGGCTGTCGCTCTTTGGAAAATCCAACAGGGAACGCCTGAGGCCCCAGAATTCCTCATTCATCCTACTGTG
TGGCTCACCACGATGAGCTTCGCAGTGTTCCTGATTCACACCGAGAGGAAAAAGGGAGTCCAGTCATCTGGAGTGCTGTTTGGTTACTGG
CTTCTCTGCTTTGTCTTGCCAGCTACCAACGCTGCCCAGCAGGCCTCCGGAGCGGGCTTCCAGAGCGACCCTGTCCGCCACCTGTCCACC
TACCTATGCCTGTCTCTGGTGGTGGCACAGTTTGTGCTGTCCTGCCTGGCGGATCAACCCCCCTTCTTCCCTGAAGACCCCCAGCAGTCT
AACCCCTGTCCAGAGACTGGGGCAGCCTTCCCCTCCAAAGCCACGTTCTGGTGGGTTTCTGGCCTGGTCTGGAGGGGATACAGGAGGCCA
CTGAGACCAAAAGACCTCTGGTCGCTTGGGAGAGAAAACTCCTCAGAAGAACTTGTTTCCCGGCTTGAAAAGGAGTGGATGAGGAACCGC
AGTGCAGCCCGGAGGCACAACAAGGCAATAGCATTTAAAAGGAAAGGCGGCAGTGGCATGAAGGCTCCAGAGACCGAGCCCTTCCTACGG
CAAGAAGGGAGCCAGTGGCGCCCACTGCTGAAGGCCATCTGGCAGGTGTTCCATTCTACCTTCCTCCTGGGGACCCTCAGCCTCATCATC
AGTGATGTCTTCAGGTTCACTGTCCCCAAGCTGCTCAGCCTTTTCCTGGAGTTTATTGGTGATCCCAAGCCTCCAGCCTGGAAGGGCTAC
CTCCTCGCCGTGCTGATGTTCCTCTCAGCCTGCCTGCAAACGCTGTTTGAGCAGCAGAACATGTACAGGCTCAAGGTGCTGCAGATGAGG
TTGCGGTCGGCCATCACTGGCCTGGTGTACAGAAAGGTCCTGGCTCTGTCCAGCGGCTCCAGAAAGGCCAGTGCGGTGGGTGATGTGGTC
AATCTGGTGTCCGTGGACGTGCAGCGGCTGACCGAGAGCGTCCTCTACCTCAACGGGCTGTGGCTGCCTCTCGTCTGGATCGTGGTCTGC
TTCGTCTATCTCTGGCAGCTCCTGGGGCCCTCCGCCCTCACTGCCATCGCTGTCTTCCTGAGCCTCCTCCCTCTGAATTTCTTCATCTCC
AAGAAAAGGAACCACCATCAGGAGGAGCAAATGAGGCAGAAGGACTCACGGGCACGGCTCACCAGCTCTATCCTCAGGAACTCGAAGACC
ATCAAGTTCCATGGCTGGGAGGGAGCCTTTCTGGACAGAGTCCTGGGCATCCGAGGCCAGGAGCTGGGCGCCTTGCGGACCTCCGGCCTC
CTCTTCTCTGTGTCGCTGGTGTCCTTCCAAGTGTCTACATTTCTGGTCGCACTGGTGGTGTTTGCTGTCCACACTCTGGTGGCCGAGAAT
GCTATGAATGCAGAGAAAGCCTTTGTGACTCTCACAGTTCTCAACATCCTCAACAAGGCCCAGGCTTTCCTGCCCTTCTCCATCCACTCC
CTCGTCCAGGCCCGGGTGTCCTTTGACCGTCTGGTCACCTTCCTCTGCCTGGAAGAAGTTGACCCTGGTGTCGTAGACTCAAGTTCCTCT
GGAAGCGCTGCCGGGAAGGATTGCATCACCATACACAGTGCCACCTTCGCCTGGTCCCAGGAAAGCCCTCCCTGCCTCCACAGAATAAAC
CTCACGGTGCCCCAGGGCTGTCTGCTGGCTGTTGTCGGTCCAGTGGGGGCAGGGAAGTCCTCCCTGCTGTCCGCCCTCCTTGGGGAGCTG
TCAAAGGTGGAGGGGTTCGTGAGCATCGAGGGTGCTGTGGCCTACGTGCCCCAGGAGGCCTGGGTGCAGAACACCTCTGTGGTAGAGAAT
GTGTGCTTCGGGCAGGAGCTGGACCCACCCTGGCTGGAGAGAGTACTAGAAGCCTGTGCCCTGCAGCCAGATGTGGACAGCTTCCCTGAG
GGAATCCACACTTCAATTGGGGAGCAGGGCATGAATCTCTCCGGAGGCCAGAAGCAGCGGCTGAGCCTGGCCCGGGCTGTATACAGAAAG
GCAGCTGTGTACCTGCTGGATGACCCCCTGGCGGCCCTGGATGCCCACGTTGGCCAGCATGTCTTCAACCAGGTCATTGGGCCTGGTGGA
CTACTCCAGGGAACAACACGGATTCTCGTGACGCACGCACTCCACATCCTGCCCCAGGCTGATTGGATCATAGTGCTGGCAAATGGGGCC
ATCGCAGAGATGGGTTCCTACCAGGAGCTTCTGCAGAGGAAGGGGGCCCTCATGTGTCTTCTGGATCAAGCCAGACAGCCAGGAGATAGA
GGAGAAGGAGAAACAGAACCTGGGACCAGCACCAAGGACCCCAGAGGCACCTCTGCAGGCAGGAGGCCCGAGCTTAGACGCGAGAGGTCC
ATCAAGTCAGTCCCTGAGAAGGACCGTACCACTTCAGAAGCCCAGACAGAGGTTCCTCTGGATGACCCTGACAGGGCAGGATGGCCAGCA
GGAAAGGACAGCATCCAATACGGCAGGGTGAAGGCCACAGTGCACCTGGCCTACCTGCGTGCCGTGGGCACCCCCCTCTGCCTCTACGCA
CTCTTCCTCTTCCTCTGCCAGCAAGTGGCCTCCTTCTGCCGGGGCTACTGGCTGAGCCTGTGGGCGGACGACCCTGCAGTAGGTGGGCAG
CAGACGCAGGCAGCCCTGCGTGGCGGGATCTTCGGGCTCCTCGGCTGTCTCCAAGCCATTGGGCTGTTTGCCTCCATGGCTGCGGTGCTC
CTAGGTGGGGCCCGGGCATCCAGGTTGCTCTTCCAGAGGCTCCTGTGGGATGTGGTGCGATCTCCCATCAGCTTCTTTGAGCGGACACCC
ATTGGTCACCTGCTAAACCGCTTCTCCAAGGAGACAGACACGGTTGACGTGGACATTCCAGACAAACTCCGGTCCCTGCTGATGTACGCC
TTTGGACTCCTGGAGGTCAGCCTGGTGGTGGCAGTGGCTACCCCACTGGCCACTGTGGCCATCCTGCCACTGTTTCTCCTCTACGCTGGG
TTTCAGAGCCTGTATGTGGTTAGCTCATGCCAGCTGAGACGCTTGGAGTCAGCCAGCTACTCGTCTGTCTGCTCCCACATGGCTGAGACG
TTCCAGGGCAGCACAGTGGTCCGGGCATTCCGAACCCAGGCCCCCTTTGTGGCTCAGAACAATGCTCGCGTAGATGAAAGCCAGAGGATC
AGTTTCCCGCGACTGGTGGCTGACAGGTGGCTTGCGGCCAATGTGGAGCTCCTGGGGAATGGCCTGGTGTTTGCAGCTGCCACGTGTGCT
GTGCTGAGCAAAGCCCACCTCAGTGCTGGCCTCGTGGGCTTCTCTGTCTCTGCTGCCCTCCAGGTGACCCAGACACTGCAGTGGGTTGTT
CGCAACTGGACAGACCTAGAGAACAGCATCGTGTCAGTGGAGCGGATGCAGGACTATGCCTGGACGCCCAAGGAGGTGATCGAAGTATGT
GATTTGACTAAAGTAAAGTTAAAATATTGTGGCGTGCATTTTAATTCTCAGGCCATAGCTCCTACCATTGAACAGATTGACCAGTCTTTT
GGCGCAACCCATCCTGGAGTGTACAACTCCGCTGAGCAGCTCTTCCATCTCAACTTCAGAGGACTGTCTTTCTCTTTTCAGTTAGACTCA
TGGACTGAGGCTCCAAAGTATGAGCCCAATTTTGCCCATGGCCTGGCTTCTCTCCAGATACCCCATGGAGCAACTGTAAAACGAATGTAC
ATCTACAGTGGCAACAGCCTGCAGGATACCAAGGCTCCCATGATGCCTCTGAGCTGTTTCCTGGGCAATGTCTATGCTGAGAGTGTAGAT
GTTCTTCGAGATGGAACTGGACCTGCAGGTTTACGACTTCGCCTACTTGCTGCAGGTTGTGGACCTGGCCTATTAGCAGATGCCAAGATG
CGGGTATTTGAACGTTCAGTGTATTTTGGTGATTCCTGCCAAGATGTTCTTAGCATGCTTGGCTCTCCACACAAAGTCTTCTATAAATCA
GAAGACAAGATGAAAATTCATTCTCCTTCCCCTCATAAACAAGTTCCATCGAAGTGTAATGACTACTTTTTTAACTACTTCACTCTTGGA
GTGGACATCCTCTTTGATGCGAATACACACAAAGTGAAGAAGTTTGTTCTACACACCAATTACCCTGGGCATTATAATTTCAACATTTAT
CATCGCTGTGAGTTCAAGATCCCACTAGCCATAAAGAAAGAAAACGCAGATGGTCAGACAGAAACATGCACGACCTACAGCAAGTGGGAC
AACATCCAGGAGCTCCTGGGCCACCCTGTGGAGAAGCCTGTTGTCCTGCACAGGTCTTCCTCCCCAAACAACACCAACCCATTTGGTTCC
ACATTCTGCTTTGGTCTTCAGCGAATGATCTTTGAGGTCATGCAGAACAACCACATTGCCTCGGTGACCCTGTATGGCCCCCCCAGGCCT
GGTAGCCACCTGAGAACAGCGGAACTCCCCTAGGGACACCACCACCCATGCCCCTCTGTCCCGTGGAACTGTGCATCACATCCTGCTCAG
TGGGCCTCTGTACCACCCTGTGGGTTTTCTTGGACACCTGGCCAGTGCTGAAGGGCTGTTGTGATGTTCTGAGGTTGGGCTCAGGCTGGG
TGCTCTGCCATGGGCTGAGTGGCCCAGATATTCTTCTGTCCATCTTTGGCCTGCTGGTGCCAGCAGGGGACACAGACTGCAAAGAGAAGC
ACAAAGTTTGAGCCTTGATTCCTGGACCCAGGAGCTCTCAACTAACAAGGAGGCAGGAGAGGTCAACCCTTGTCCCATGCACATTGGGAA
GACTTGGGGCTCTTTCTGTGACTGAGGACACAGGCACCCAGGATAAGGACAAGGTCCTGCCTTTGGCTCCACATTGCCACATGACCCTTA
AGGCAAGCAGGTAGCGTGTCCATAGTACTTGGTTGCGACATTTGCACTACATCCACTTTAGTTACTTGATGAGCTGGCTGTGGCCAGGGT
GGCCCACCTGCCCTTCCCTGTTCCTTTCTTGCACGCGCTCCCTGCCTGGGCACACCAAACTGGTTGAAACACAGCTTTCTACCATCCAGG
TACATGCCCAGGCCTGGTTCTCACCCCTGTTGGAGTCAGCTTTCAAGATTGCCTGTGCCCCTGCTCTGCCCCATCCTGGCTGGCAGGGCT
GCATGTTTCCATCCTGTTTGCCTCTTTTATTTAATGCCAAAGTTTTAGCCAAAGACATCTTCCTACTTTTGTTGTGTTTCAGCATTCTGT
TCTGCACTGTGGGCTGGCTCTCTGCCCCAACCCTGGGCACTGGCCCCTGGCTGGGCCATTTCATGGCTCAAAGCCTCTGGGGGCTCAAGG
AAGGCTGGGCTGCTCAGTCCCTTCATGGGTCTTGCTAATGGAAAGTAGCATATATGTGCTTTAAAAATATTAATCCTTTTGAAAAGAACT
GAGAAGAAAAATGTATAATTTTATCCCATTTTTAATATTTTGGTCTAGCAACTTGTGATACATAGATGACAATTTTGTGAGTTTTTCAAA
TGTGTGTACAGATTTTTGTAAATATGACTCTTTTGTAATTAACTCATGTACAGCCTCATCCTGTATAGTTTAATGATGAATGTGCAGGGG
ACCTGTCTCAGGCTCCTATATGGTTCCTGGGCCTTATAGCCAGGTTTGTGTGGCGCTCCCGACTTTTGTGACTGACTGGTGTCTTCCCAT
TTGGACTGTGGCCTGGCCAGAGCCCCTTGCATATCCCCACTGTCAGGGGCAGCCAGGACTGTTCCCATCCTCCTGGAATGGGGGAACCTT
CCTTATCCCCTGCCCACATCCCCTCTCCAATAAAGCACCTGTGCCCTCAGCAATGGCCTGCCATGTGCTGTTGCTGGGATGTTTGTATTA
A

>311_311_1_ABCC6-C16orf70_ABCC6_chr16_16253339_ENST00000205557_C16orf70_chr16_67165189_ENST00000219139_length(amino acids)=1590AA_BP=1245
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVA
LWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQ
FVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAI
AFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSA
CLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGP
SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQ
VSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCIT
IHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP
WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILV
THALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRT
TSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGI
FGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVV
AVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRW
LAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEVIEVCDLTKVKLKYC
GVHFNSQAIAPTIEQIDQSFGATHPGVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPNFAHGLASLQIPHGATVKRMYIYSGNSLQDT
KAPMMPLSCFLGNVYAESVDVLRDGTGPAGLRLRLLAAGCGPGLLADAKMRVFERSVYFGDSCQDVLSMLGSPHKVFYKSEDKMKIHSPS
PHKQVPSKCNDYFFNYFTLGVDILFDANTHKVKKFVLHTNYPGHYNFNIYHRCEFKIPLAIKKENADGQTETCTTYSKWDNIQELLGHPV
EKPVVLHRSSSPNNTNPFGSTFCFGLQRMIFEVMQNNHIASVTLYGPPRPGSHLRTAELP

--------------------------------------------------------------
>311_311_2_ABCC6-C16orf70_ABCC6_chr16_16253339_ENST00000205557_C16orf70_chr16_67165189_ENST00000569600_length(transcript)=4803nt_BP=3765nt
CGCTGGGACCCACGACGACAGAAGGCGCCGATGGCCGCGCCTGCTGAGCCCTGCGCGGGGCAGGGGGTCTGGAACCAGACAGAGCCTGAA
CCTGCCGCCACCAGCCTGCTGAGCCTGTGCTTCCTGAGAACAGCAGGGGTCTGGGTACCCCCCATGTACCTCTGGGTCCTTGGTCCCATC
TACCTCCTCTTCATCCACCACCATGGCCGGGGCTACCTCCGGATGTCCCCACTCTTCAAAGCCAAGATGGTGCTTGGATTCGCCCTCATA
GTCCTGTGTACCTCCAGCGTGGCTGTCGCTCTTTGGAAAATCCAACAGGGAACGCCTGAGGCCCCAGAATTCCTCATTCATCCTACTGTG
TGGCTCACCACGATGAGCTTCGCAGTGTTCCTGATTCACACCGAGAGGAAAAAGGGAGTCCAGTCATCTGGAGTGCTGTTTGGTTACTGG
CTTCTCTGCTTTGTCTTGCCAGCTACCAACGCTGCCCAGCAGGCCTCCGGAGCGGGCTTCCAGAGCGACCCTGTCCGCCACCTGTCCACC
TACCTATGCCTGTCTCTGGTGGTGGCACAGTTTGTGCTGTCCTGCCTGGCGGATCAACCCCCCTTCTTCCCTGAAGACCCCCAGCAGTCT
AACCCCTGTCCAGAGACTGGGGCAGCCTTCCCCTCCAAAGCCACGTTCTGGTGGGTTTCTGGCCTGGTCTGGAGGGGATACAGGAGGCCA
CTGAGACCAAAAGACCTCTGGTCGCTTGGGAGAGAAAACTCCTCAGAAGAACTTGTTTCCCGGCTTGAAAAGGAGTGGATGAGGAACCGC
AGTGCAGCCCGGAGGCACAACAAGGCAATAGCATTTAAAAGGAAAGGCGGCAGTGGCATGAAGGCTCCAGAGACCGAGCCCTTCCTACGG
CAAGAAGGGAGCCAGTGGCGCCCACTGCTGAAGGCCATCTGGCAGGTGTTCCATTCTACCTTCCTCCTGGGGACCCTCAGCCTCATCATC
AGTGATGTCTTCAGGTTCACTGTCCCCAAGCTGCTCAGCCTTTTCCTGGAGTTTATTGGTGATCCCAAGCCTCCAGCCTGGAAGGGCTAC
CTCCTCGCCGTGCTGATGTTCCTCTCAGCCTGCCTGCAAACGCTGTTTGAGCAGCAGAACATGTACAGGCTCAAGGTGCTGCAGATGAGG
TTGCGGTCGGCCATCACTGGCCTGGTGTACAGAAAGGTCCTGGCTCTGTCCAGCGGCTCCAGAAAGGCCAGTGCGGTGGGTGATGTGGTC
AATCTGGTGTCCGTGGACGTGCAGCGGCTGACCGAGAGCGTCCTCTACCTCAACGGGCTGTGGCTGCCTCTCGTCTGGATCGTGGTCTGC
TTCGTCTATCTCTGGCAGCTCCTGGGGCCCTCCGCCCTCACTGCCATCGCTGTCTTCCTGAGCCTCCTCCCTCTGAATTTCTTCATCTCC
AAGAAAAGGAACCACCATCAGGAGGAGCAAATGAGGCAGAAGGACTCACGGGCACGGCTCACCAGCTCTATCCTCAGGAACTCGAAGACC
ATCAAGTTCCATGGCTGGGAGGGAGCCTTTCTGGACAGAGTCCTGGGCATCCGAGGCCAGGAGCTGGGCGCCTTGCGGACCTCCGGCCTC
CTCTTCTCTGTGTCGCTGGTGTCCTTCCAAGTGTCTACATTTCTGGTCGCACTGGTGGTGTTTGCTGTCCACACTCTGGTGGCCGAGAAT
GCTATGAATGCAGAGAAAGCCTTTGTGACTCTCACAGTTCTCAACATCCTCAACAAGGCCCAGGCTTTCCTGCCCTTCTCCATCCACTCC
CTCGTCCAGGCCCGGGTGTCCTTTGACCGTCTGGTCACCTTCCTCTGCCTGGAAGAAGTTGACCCTGGTGTCGTAGACTCAAGTTCCTCT
GGAAGCGCTGCCGGGAAGGATTGCATCACCATACACAGTGCCACCTTCGCCTGGTCCCAGGAAAGCCCTCCCTGCCTCCACAGAATAAAC
CTCACGGTGCCCCAGGGCTGTCTGCTGGCTGTTGTCGGTCCAGTGGGGGCAGGGAAGTCCTCCCTGCTGTCCGCCCTCCTTGGGGAGCTG
TCAAAGGTGGAGGGGTTCGTGAGCATCGAGGGTGCTGTGGCCTACGTGCCCCAGGAGGCCTGGGTGCAGAACACCTCTGTGGTAGAGAAT
GTGTGCTTCGGGCAGGAGCTGGACCCACCCTGGCTGGAGAGAGTACTAGAAGCCTGTGCCCTGCAGCCAGATGTGGACAGCTTCCCTGAG
GGAATCCACACTTCAATTGGGGAGCAGGGCATGAATCTCTCCGGAGGCCAGAAGCAGCGGCTGAGCCTGGCCCGGGCTGTATACAGAAAG
GCAGCTGTGTACCTGCTGGATGACCCCCTGGCGGCCCTGGATGCCCACGTTGGCCAGCATGTCTTCAACCAGGTCATTGGGCCTGGTGGA
CTACTCCAGGGAACAACACGGATTCTCGTGACGCACGCACTCCACATCCTGCCCCAGGCTGATTGGATCATAGTGCTGGCAAATGGGGCC
ATCGCAGAGATGGGTTCCTACCAGGAGCTTCTGCAGAGGAAGGGGGCCCTCATGTGTCTTCTGGATCAAGCCAGACAGCCAGGAGATAGA
GGAGAAGGAGAAACAGAACCTGGGACCAGCACCAAGGACCCCAGAGGCACCTCTGCAGGCAGGAGGCCCGAGCTTAGACGCGAGAGGTCC
ATCAAGTCAGTCCCTGAGAAGGACCGTACCACTTCAGAAGCCCAGACAGAGGTTCCTCTGGATGACCCTGACAGGGCAGGATGGCCAGCA
GGAAAGGACAGCATCCAATACGGCAGGGTGAAGGCCACAGTGCACCTGGCCTACCTGCGTGCCGTGGGCACCCCCCTCTGCCTCTACGCA
CTCTTCCTCTTCCTCTGCCAGCAAGTGGCCTCCTTCTGCCGGGGCTACTGGCTGAGCCTGTGGGCGGACGACCCTGCAGTAGGTGGGCAG
CAGACGCAGGCAGCCCTGCGTGGCGGGATCTTCGGGCTCCTCGGCTGTCTCCAAGCCATTGGGCTGTTTGCCTCCATGGCTGCGGTGCTC
CTAGGTGGGGCCCGGGCATCCAGGTTGCTCTTCCAGAGGCTCCTGTGGGATGTGGTGCGATCTCCCATCAGCTTCTTTGAGCGGACACCC
ATTGGTCACCTGCTAAACCGCTTCTCCAAGGAGACAGACACGGTTGACGTGGACATTCCAGACAAACTCCGGTCCCTGCTGATGTACGCC
TTTGGACTCCTGGAGGTCAGCCTGGTGGTGGCAGTGGCTACCCCACTGGCCACTGTGGCCATCCTGCCACTGTTTCTCCTCTACGCTGGG
TTTCAGAGCCTGTATGTGGTTAGCTCATGCCAGCTGAGACGCTTGGAGTCAGCCAGCTACTCGTCTGTCTGCTCCCACATGGCTGAGACG
TTCCAGGGCAGCACAGTGGTCCGGGCATTCCGAACCCAGGCCCCCTTTGTGGCTCAGAACAATGCTCGCGTAGATGAAAGCCAGAGGATC
AGTTTCCCGCGACTGGTGGCTGACAGGTGGCTTGCGGCCAATGTGGAGCTCCTGGGGAATGGCCTGGTGTTTGCAGCTGCCACGTGTGCT
GTGCTGAGCAAAGCCCACCTCAGTGCTGGCCTCGTGGGCTTCTCTGTCTCTGCTGCCCTCCAGGTGACCCAGACACTGCAGTGGGTTGTT
CGCAACTGGACAGACCTAGAGAACAGCATCGTGTCAGTGGAGCGGATGCAGGACTATGCCTGGACGCCCAAGGAGGTGATCGAAGTATGT
GATTTGACTAAAGTAAAGTTAAAATATTGTGGCGTGCATTTTAATTCTCAGGCCATAGCTCCTACCATTGAACAGATTGACCAGTCTTTT
GGCGCAACCCATCCTGGAGTGTACAACTCCGCTGAGCAGCTCTTCCATCTCAACTTCAGAGGACTGTCTTTCTCTTTTCAGTTAGACTCA
TGGACTGAGGCTCCAAAGTATGAGCCCAATTTTGCCCATGGCCTGGCTTCTCTCCAGATACCCCATGGAGCAACTGTAAAACGAATGTAC
ATCTACAGTGGCAACAGCCTGCAGGATACCAAGGCTCCCATGATGCCTCTGAGCTGTTTCCTGGGCAATGTCTATGCTGAGAGTGTAGAT
GTTCTTCGAGATGGAACTGGACCTGCAGGTTTACGACTTCGCCTACTTGCTGCAGGTTGTGGACCTGGCCTATTAGCAGATGCCAAGATG
CGGGTATTTGAACGTTCAGTGTATTTTGGTGATTCCTGCCAAGATGTTCTTAGCATGCTTGGCTCTCCACACAAAGTCTTCTATAAATCA
GAAGACAAGATGAAAATTCATTCTCCTTCCCCTCATAAACAAGTTCCATCGAAGTGTAATGACTACTTTTTTAACTACTTCACTCTTGGA
GTGGACATCCTCTTTGATGCGAATACACACAAAGTGAAGAAGTTTGTTCTACACACCAATTACCCTGGGCATTATAATTTCAACATTTAT
CATCGCTGTGAGTTCAAGATCCCACTAGCCATAAAGAAAGAAAACGCAGATGGTCAGACAGAAACATGCACGACCTACAGCAAGTGGGAC
AACATCCAGGAGCTCCTGGGCCACCCTGTGGAGAAGCCTGTTGTCCTGCACAGGTCTTCCTCCCCAAACAACACCAACCCATTTGGTTCC
ACATTCTGCTTTGGTCTTCAGCGAATGATCTTTGAGGTCATGCAGAACAACCACATTGCCTCGGTGACCCTGTATGGCCCCCCCAGGCCT
GGTAGCCACCTGAGAACAGCGGAACTCCCCTAG

>311_311_2_ABCC6-C16orf70_ABCC6_chr16_16253339_ENST00000205557_C16orf70_chr16_67165189_ENST00000569600_length(amino acids)=1590AA_BP=1245
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVA
LWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQ
FVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAI
AFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSA
CLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGP
SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQ
VSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCIT
IHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP
WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILV
THALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRT
TSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGI
FGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVV
AVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRW
LAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEVIEVCDLTKVKLKYC
GVHFNSQAIAPTIEQIDQSFGATHPGVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPNFAHGLASLQIPHGATVKRMYIYSGNSLQDT
KAPMMPLSCFLGNVYAESVDVLRDGTGPAGLRLRLLAAGCGPGLLADAKMRVFERSVYFGDSCQDVLSMLGSPHKVFYKSEDKMKIHSPS
PHKQVPSKCNDYFFNYFTLGVDILFDANTHKVKKFVLHTNYPGHYNFNIYHRCEFKIPLAIKKENADGQTETCTTYSKWDNIQELLGHPV
EKPVVLHRSSSPNNTNPFGSTFCFGLQRMIFEVMQNNHIASVTLYGPPRPGSHLRTAELP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABCC6-C16orf70


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCC6-C16orf70


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCC6-C16orf70


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC6C0033847Pseudoxanthoma Elasticum26CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneABCC6C1867450Pseudoxanthoma Elasticum, Incomplete11CTD_human;GENOMICS_ENGLAND
HgeneABCC6C0376359Gronblad-Strandberg Syndrome8CTD_human
HgeneABCC6C1859727Arterial calcification of infancy2CTD_human;ORPHANET
HgeneABCC6C3276161ARTERIAL CALCIFICATION, GENERALIZED, OF INFANCY, 22GENOMICS_ENGLAND;UNIPROT
HgeneABCC6C0009402Colorectal Carcinoma1CTD_human
HgeneABCC6C0009404Colorectal Neoplasms1CTD_human
HgeneABCC6C0235874Disease Exacerbation1CTD_human
HgeneABCC6C0264955Idiopathic arterial calcification of infancy1ORPHANET