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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:ATP9B-CHGB (FusionGDB2 ID:HG374868TG1114)

Fusion Gene Summary for ATP9B-CHGB

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP9B-CHGB
Fusion gene ID: hg374868tg1114
HgeneTgene
Gene symbol

ATP9B

CHGB

Gene ID

374868

1114

Gene nameATPase phospholipid transporting 9B (putative)chromogranin B
SynonymsATPASEP|ATPIIB|HUSSY-20|NEO1L|hMMR1SCG1
Cytomap('ATP9B')('CHGB')

18q23

20p12.3

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IIBATPase type IV, phospholipid transporting (P-type)ATPase, class II, type 9Bmacrophage MHC receptor 1secretogranin-1cgBsecretogranin Bsecretogranin IsgI
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000307671, ENST00000426216, 
ENST00000543761, ENST00000458297, 
ENST00000586722, ENST00000591464, 
Fusion gene scores* DoF score15 X 16 X 5=12008 X 11 X 4=352
# samples 1510
** MAII scorelog2(15/1200*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/352*10)=-1.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP9B [Title/Abstract] AND CHGB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP9B(77134093)-CHGB(5903356), # samples:4
Anticipated loss of major functional domain due to fusion event.ATP9B-CHGB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP9B-CHGB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATP9B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CHGB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-QR-A702-01AATP9Bchr18

77134093

+CHGBchr20

5903356

+
ChimerDB4PCPGTCGA-QT-A5XK-01AATP9Bchr18

77134093

+CHGBchr20

5903356

+
ChimerDB4PCPGTCGA-SR-A6MY-01AATP9Bchr18

77134094

+CHGBchr20

5903357

+
ChimerDB4PCPGTCGA-WB-A81S-01AATP9Bchr18

77134093

+CHGBchr20

5903356

+
ChimerDB4PCPGTCGA-WB-A81T-01AATP9Bchr18

77134093

+CHGBchr20

5903356

+


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Fusion Gene ORF analysis for ATP9B-CHGB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000307671ENST00000488832ATP9Bchr18

77134094

+CHGBchr20

5903357

+
5CDS-intronENST00000307671ENST00000488832ATP9Bchr18

77134093

+CHGBchr20

5903356

+
5CDS-intronENST00000426216ENST00000488832ATP9Bchr18

77134094

+CHGBchr20

5903357

+
5CDS-intronENST00000426216ENST00000488832ATP9Bchr18

77134093

+CHGBchr20

5903356

+
5CDS-intronENST00000543761ENST00000488832ATP9Bchr18

77134094

+CHGBchr20

5903357

+
5CDS-intronENST00000543761ENST00000488832ATP9Bchr18

77134093

+CHGBchr20

5903356

+
In-frameENST00000307671ENST00000378961ATP9Bchr18

77134094

+CHGBchr20

5903357

+
In-frameENST00000307671ENST00000378961ATP9Bchr18

77134093

+CHGBchr20

5903356

+
In-frameENST00000426216ENST00000378961ATP9Bchr18

77134094

+CHGBchr20

5903357

+
In-frameENST00000426216ENST00000378961ATP9Bchr18

77134093

+CHGBchr20

5903356

+
In-frameENST00000543761ENST00000378961ATP9Bchr18

77134094

+CHGBchr20

5903357

+
In-frameENST00000543761ENST00000378961ATP9Bchr18

77134093

+CHGBchr20

5903356

+
intron-3CDSENST00000458297ENST00000378961ATP9Bchr18

77134094

+CHGBchr20

5903357

+
intron-3CDSENST00000458297ENST00000378961ATP9Bchr18

77134093

+CHGBchr20

5903356

+
intron-3CDSENST00000586722ENST00000378961ATP9Bchr18

77134094

+CHGBchr20

5903357

+
intron-3CDSENST00000586722ENST00000378961ATP9Bchr18

77134093

+CHGBchr20

5903356

+
intron-3CDSENST00000591464ENST00000378961ATP9Bchr18

77134094

+CHGBchr20

5903357

+
intron-3CDSENST00000591464ENST00000378961ATP9Bchr18

77134093

+CHGBchr20

5903356

+
intron-intronENST00000458297ENST00000488832ATP9Bchr18

77134094

+CHGBchr20

5903357

+
intron-intronENST00000458297ENST00000488832ATP9Bchr18

77134093

+CHGBchr20

5903356

+
intron-intronENST00000586722ENST00000488832ATP9Bchr18

77134094

+CHGBchr20

5903357

+
intron-intronENST00000586722ENST00000488832ATP9Bchr18

77134093

+CHGBchr20

5903356

+
intron-intronENST00000591464ENST00000488832ATP9Bchr18

77134094

+CHGBchr20

5903357

+
intron-intronENST00000591464ENST00000488832ATP9Bchr18

77134093

+CHGBchr20

5903356

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000426216ATP9Bchr1877134093+ENST00000378961CHGBchr205903356+487530951731301037
ENST00000307671ATP9Bchr1877134093+ENST00000378961CHGBchr205903356+487230921431271037
ENST00000543761ATP9Bchr1877134093+ENST00000378961CHGBchr205903356+28551075131110365
ENST00000426216ATP9Bchr1877134094+ENST00000378961CHGBchr205903357+487330941731511044
ENST00000307671ATP9Bchr1877134094+ENST00000378961CHGBchr205903357+487030911431481044
ENST00000543761ATP9Bchr1877134094+ENST00000378961CHGBchr205903357+2853107410412540499

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000426216ENST00000378961ATP9Bchr1877134093+CHGBchr205903356+0.0004837260.99951625
ENST00000307671ENST00000378961ATP9Bchr1877134093+CHGBchr205903356+0.0004864310.9995136
ENST00000543761ENST00000378961ATP9Bchr1877134093+CHGBchr205903356+0.0006232020.99937683
ENST00000426216ENST00000378961ATP9Bchr1877134094+CHGBchr205903357+0.0007599470.99924004
ENST00000307671ENST00000378961ATP9Bchr1877134094+CHGBchr205903357+0.0007641160.99923587
ENST00000543761ENST00000378961ATP9Bchr1877134094+CHGBchr205903357+0.0097140570.99028593

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Fusion Genomic Features for ATP9B-CHGB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATP9B-CHGB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:77134093/chr20:5903356)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHGBchr18:77134093chr20:5903356ENST0000037896105163_1710678.0Compositional biasNote=Poly-Glu
TgeneCHGBchr18:77134094chr20:5903357ENST0000037896105163_1710678.0Compositional biasNote=Poly-Glu
TgeneCHGBchr18:77134093chr20:5903356ENST0000037896105116_1200678.0RegionNote=O-glycosylated at one site
TgeneCHGBchr18:77134094chr20:5903357ENST0000037896105116_1200678.0RegionNote=O-glycosylated at one site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+1291032_103801137.0Topological domainExtracellular
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+1291062_106701137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+1291089_110501137.0Topological domainExtracellular
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+1291131_114701137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129169_17301137.0Topological domainExtracellular
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129197_38001137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+1291_14601137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129402_40901137.0Topological domainExtracellular
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129432_93001137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129952_96301137.0Topological domainExtracellular
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129983_101201137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+1301032_103801148.0Topological domainExtracellular
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+1301062_106701148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+1301089_110501148.0Topological domainExtracellular
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+1301131_114701148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130169_17301148.0Topological domainExtracellular
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130197_38001148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+1301_14601148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130402_40901148.0Topological domainExtracellular
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130432_93001148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130952_96301148.0Topological domainExtracellular
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130983_101201148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+1291032_103801137.0Topological domainExtracellular
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+1291062_106701137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+1291089_110501137.0Topological domainExtracellular
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+1291131_114701137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129169_17301137.0Topological domainExtracellular
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129197_38001137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+1291_14601137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129402_40901137.0Topological domainExtracellular
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129432_93001137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129952_96301137.0Topological domainExtracellular
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129983_101201137.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+1301032_103801148.0Topological domainExtracellular
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+1301062_106701148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+1301089_110501148.0Topological domainExtracellular
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+1301131_114701148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130169_17301148.0Topological domainExtracellular
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130197_38001148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+1301_14601148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130402_40901148.0Topological domainExtracellular
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130432_93001148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130952_96301148.0Topological domainExtracellular
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130983_101201148.0Topological domainCytoplasmic
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+1291013_103101137.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+1291039_106101137.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+1291068_108801137.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+1291106_113001137.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129147_16801137.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129174_19601137.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129381_40101137.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129410_43101137.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129931_95101137.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000307671+129964_98201137.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+1301013_103101148.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+1301039_106101148.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+1301068_108801148.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+1301106_113001148.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130147_16801148.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130174_19601148.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130381_40101148.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130410_43101148.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130931_95101148.0TransmembraneHelical
HgeneATP9Bchr18:77134093chr20:5903356ENST00000426216+130964_98201148.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+1291013_103101137.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+1291039_106101137.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+1291068_108801137.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+1291106_113001137.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129147_16801137.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129174_19601137.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129381_40101137.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129410_43101137.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129931_95101137.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000307671+129964_98201137.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+1301013_103101148.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+1301039_106101148.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+1301068_108801148.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+1301106_113001148.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130147_16801148.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130174_19601148.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130381_40101148.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130410_43101148.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130931_95101148.0TransmembraneHelical
HgeneATP9Bchr18:77134094chr20:5903357ENST00000426216+130964_98201148.0TransmembraneHelical


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Fusion Gene Sequence for ATP9B-CHGB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8296_8296_1_ATP9B-CHGB_ATP9B_chr18_77134093_ENST00000307671_CHGB_chr20_5903356_ENST00000378961_length(transcript)=4872nt_BP=3092nt
GGGGCGGTCGGAACATGGCGGACCAGATCCCGCTTTACCCGGTGCGTAGCGCAGCGGCGGCCGCAGCCAACCGCAAACGCGCGGCCTACT
ACAGCGCCGCGGGGCCCAGGCCGGGAGCCGACCGGCACAGCAGGTACCAGCTGGAGGATGAGTCTGCGCATTTGGATGAAATGCCACTAA
TGATGTCTGAAGAAGGCTTTGAGAATGAGGAAAGTGATTACCACACCTTACCACGAGCCAGGATAATGCAAAGGAAAAGAGGACTGGAGT
GGTTTGTCTGTGATGGCTGGAAGTTCCTCTGTACCAGTTGCTGTGGTTGGCTGATAAATATTTGTCGAAGAAAGAAAGAGCTGAAAGCTC
GCACAGTATGGCTTGGATGTCCTGAAAAGTGTGAAGAAAAACATCCCAGGAATTCTATAAAAAATCAAAAATACAATGTGTTTACCTTTA
TACCTGGGGTTTTGTATGAACAATTCAAGTTTTTCTTGAATCTCTATTTTCTAGTAATATCCTGCTCACAGTTTGTACCAGCATTGAAAA
TAGGCTATCTCTACACCTACTGGGCTCCTCTGGGATTTGTCTTGGCTGTTACTATGACACGGGAAGCAATTGATGAATTTCGGCGTTTTC
AGCGTGACAAGGAAGTGAATTCACAACTATATAGCAAGCTTACAGTAAGAGGTAAAGTGCAAGTTAAGAGTTCAGACATACAAGTTGGAG
ACCTCATCATAGTGGAAAAGAATCAAAGAATTCCATCGGACATGGTGTTTCTTAGGACTTCAGAAAAAGCAGGTTCGTGTTTTATTCGAA
CTGATCAACTAGATGGTGAAACTGACTGGAAGCTGAAGGTGGCAGTGAGCTGCACGCAACAGCTGCCGGCTCTGGGGGACCTTTTTTCTA
TCAGTGCTTATGTTTATGCTCAGAAACCACAAATGGACATTCACAGTTTCGAAGGCACATTTACCAGGGAAGACAGTGACCCGCCCATTC
ATGAAAGTCTCAGCATAGAAAATACATTGTGGGCAAGCACCATTGTTGCATCAGGTACTGTAATAGGTGTTGTCATTTATACCGGAAAAG
AGACTCGAAGTGTAATGAACACATCCAATCCAAAAAATAAGGTTGGTTTGTTGGACCTTGAACTCAATCGGCTGACGAAAGCGCTATTTT
TGGCTTTAGTTGCTCTTTCCATTGTTATGGTAACCTTACAAGGATTTGTGGGTCCATGGTACCGCAATCTTTTTCGGTTCCTTCTCCTCT
TTTCTTACATCATTCCCATAAGTTTGCGTGTGAACTTGGACATGGGCAAAGCGGTGTATGGATGGATGATGATGAAAGATGAGAACATCC
CTGGCACGGTCGTTCGGACCAGCACTATCCCAGAGGAACTTGGGCGCCTGGTGTATTTATTGACAGACAAAACAGGAACCCTCACCCAGA
ATGAAATGATATTTAAGCGGCTGCACCTGGGCACCGTGTCCTATGGCGCCGACACGATGGATGAGATCCAGAGCCATGTCAGGGACTCCT
ACTCACAGATGCAGTCTCAAGCTGGTGGAAACAATACTGGTTCAACTCCACTAAGAAAAGCCCAATCTTCAGCTCCCAAAGTTAGGAAAA
GTGTCAGTAGTCGAATCCATGAAGCCGTGAAAGCCATCGTGCTGTGTCACAACGTGACCCCCGTGTATGAGTCTCGGGCCGGCGTTACTG
AGGAGACTGAGTTCGCAGAGGCTGACCAAGACTTCAGTGATGAGAATCGCACCTACCAGGCTTCCAGCCCGGATGAGGTCGCTCTGGTGC
AGTGGACAGAGAGTGTGGGCCTCACGCTGGTCAGCAGGGACCTCACCTCCATGCAGCTGAAGACCCCCAGTGGCCAGGTCCTCAGCTTCT
GCATTCTGCAGCTGTTTCCCTTCACCTCCGAGAGCAAGCGGATGGGCGTCATCGTCAGGGATGAATCCACGGCAGAAATCACATTCTACA
TGAAGGGCGCTGACGTGGCCATGTCTCCTATCGTGCAGTATAATGACTGGCTGGAAGAGGAGTGCGGAAACATGGCTCGCGAAGGACTGC
GGACCCTCGTGGTTGCAAAGAAGGCGTTGACAGAGGAGCAGTACCAGGACTTTGAGAGCCGATACACTCAAGCCAAGCTGAGCATGCACG
ACAGGTCCCTCAAGGTGGCCGCGGTAGTCGAGAGCCTGGAGAGGGAGATGGAACTGCTGTGCCTCACCGGCGTGGAGGACCAGCTGCAGG
CAGACGTGCGGCCCACGCTGGAGATGCTGCGCAACGCCGGGATCAAGATATGGATGCTAACAGGCGATAAACTCGAGACAGCTACCTGCA
TTGCCAAAAGTTCACATCTCGTGTCTAGAACACAAGATATTCATATTTTCAGACAGGTAACCAGTCGGGGAGAGGCACATTTGGAGCTGA
ATGCATTTCGAAGGAAGCATGATTGTGCACTAGTCATATCTGGGGACTCTCTGGAGGTTTGTCTAAAGTACTACGAGCATGAATTTGTGG
AGCTGGCCTGCCAGTGCCCTGCCGTGGTTTGCTGCCGCTGCTCACCCACCCAGAAGGCCCGCATTGTGACACTGCTGCAGCAGCACACAG
GGAGACGCACCTGCGCCATCGGTGATGGAGGAAATGATGTCAGCATGATTCAGGCAGCAGACTGTGGGATTGGGATTGAGGGAAAGGAGG
GTAAACAGGCCTCGCTGGCGGCCGACTTCTCCATCACGCAGTTCCGGCACATAGGCAGGCTGCTCATGGTGCACGGGCGGAACAGCTACA
AGAGGTCGGCGGCACTCGGCCAGTTCGTCATGCACAGGGGCCTTATCATCTCCACCATGCAGGCTGTGTTTTCCTCAGTCTTCTACTTCG
CATCCGTCCCTTTGTATCAGGGCTTCCTCATGGTGGGGTATGCCACCATATACACCATGTTCCCAGTGTTCTCCTTAGTGCTGGACCAGG
ACGTGAAGCCAGAGATGGCGATGCTCTACCCGGAGCTGTACAAGGACCTCACCAAGGGAAGATCCTTGTCCTTCAAAACCTTCCTCATCT
GGGTTTTAATAAGTATTTACCAAGATATTTTGAGAGCCAGGAGAGACACAAAACGCTTTTCTCAATGAAAGAAAGCAGGCTTCAGCTATA
AAAAAAGAGGAGTTAGTGGCCAGATCGGAAACACATGCTGCCGGGCATTCTCAGGAGAAGACACATAGCCGAGAGAAGAGTAGCCAGGAG
AGTGGAGAGGAGACAGGGAGCCAGGAGAATCACCCCCAGGAGTCTAAAGGCCAACCCCGAAGCCAGGAAGAATCTGAGGAAGGTGAGGAA
GATGCCACCTCTGAGGTGGACAAACGACGCACGAGGCCCAGACACCACCACGGGAGGAGCAGGCCCGACAGGTCCTCTCAAGGAGGGAGT
CTTCCCTCTGAGGAAAAGGGACACCCCCAGGAGGAATCTGAGGAGTCAAACGTCAGCATGGCCAGTTTAGGGGAAAAGAGGGACCACCAT
TCAACCCACTACAGGGCTTCAGAGGAAGAACCTGAATATGGAGAAGAAATAAAGGGTTATCCAGGCGTCCAGGCCCCTGAGGACCTGGAG
TGGGAGCGCTATAGGGGCAGAGGAAGTGAAGAATACAGGGCTCCAAGACCTCAGAGTGAGGAGAGTTGGGATGAGGAGGACAAGAGAAAC
TACCCCAGCTTAGAGCTTGATAAGATGGCACATGGATATGGTGAAGAAAGTGAGGAAGAGAGGGGCCTTGAGCCGGGAAAGGGACGCCAT
CACAGAGGCAGGGGAGGGGAGCCACGTGCCTATTTCATGTCTGACACCAGAGAAGAGAAAAGGTTCTTGGGTGAAGGACACCACCGTGTC
CAAGAAAACCAGATGGACAAGGCAAGGAGGCATCCACAAGGTGCGTGGAAAGAGCTGGACAGAAATTATCTCAACTACGGTGAGGAAGGA
GCCCCAGGGAAGTGGCAGCAGCAGGGAGACCTGCAGGACACTAAAGAAAACAGGGAGGAAGCTAGGTTTCAAGATAAACAATATAGCTCC
CATCACACAGCTGAAAAGAGGAAGAGATTAGGGGAACTGTTCAACCCATACTACGACCCTCTCCAGTGGAAGAGCAGCCATTTTGAAAGA
AGAGACAACATGAATGACAATTTTCTCGAGGGTGAGGAGGAAAATGAGCTGACCTTGAACGAGAAGAATTTCTTCCCAGAATACAACTAT
GACTGGTGGGAGAAAAAGCCCTTCTCTGAGGATGTGAACTGGGGGTATGAGAAGAGAAACCTCGCCAGGGTCCCCAAGCTGGACCTGAAA
AGGCAATATGACAGGGTGGCCCAACTGGACCAGCTCCTTCACTACAGGAAGAAGTCAGCTGAGTTTCCAGACTTCTATGATTCTGAGGAG
CCGGTGAGCACCCACCAGGAGGCAGAAAATGAAAAGGACAGGGCTGACCAGACAGTCCTGACAGAGGACGAGAAAAAAGAACTCGAAAAC
TTGGCTGCAATGGATTTGGAACTACAGAAGATAGCTGAGAAATTCAGCCAAAGGGGCTGACTGTCATTGGAGCGGTGGGCACTGTTAAGA
AGCAGCCATCACATGATCTGTTTTTCACCACTTCACTGAAAGACACCATTTATCTACCCAAGGGCAGAAAGTAGAACTTACTATTCATTA
AATGTTTGACACAATTGGAATTGTCTTTAATTTCTGTCAGAATGCTATTGAAAATGTGAATTGCATGACTTGTAGCATATTCTTTTCTGC
AAAATAGACATATTAACATGCTTATGACAATGACTGTGCTACTGTCTTTGGAAAAATGTTTGTCTCAGTTGGAAATAATAAAAGATTCAC

>8296_8296_1_ATP9B-CHGB_ATP9B_chr18_77134093_ENST00000307671_CHGB_chr20_5903356_ENST00000378961_length(amino acids)=1037AA_BP=
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCD
GWKFLCTSCCGWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY
TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLD
GETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSV
MNTSNPKNKVGLLDLELNRLTKALFLALVALSIVMVTLQGFVGPWYRNLFRFLLLFSYIIPISLRVNLDMGKAVYGWMMMKDENIPGTVV
RTSTIPEELGRLVYLLTDKTGTLTQNEMIFKRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTPLRKAQSSAPKVRKSVSSR
IHEAVKAIVLCHNVTPVYESRAGVTEETEFAEADQDFSDENRTYQASSPDEVALVQWTESVGLTLVSRDLTSMQLKTPSGQVLSFCILQL
FPFTSESKRMGVIVRDESTAEITFYMKGADVAMSPIVQYNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDFESRYTQAKLSMHDRSLK
VAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSRGEAHLELNAFRR
KHDCALVISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQAS
LAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSLVLDQDVKPE

--------------------------------------------------------------
>8296_8296_2_ATP9B-CHGB_ATP9B_chr18_77134093_ENST00000426216_CHGB_chr20_5903356_ENST00000378961_length(transcript)=4875nt_BP=3095nt
AAAGGGGCGGTCGGAACATGGCGGACCAGATCCCGCTTTACCCGGTGCGTAGCGCAGCGGCGGCCGCAGCCAACCGCAAACGCGCGGCCT
ACTACAGCGCCGCGGGGCCCAGGCCGGGAGCCGACCGGCACAGCAGGTACCAGCTGGAGGATGAGTCTGCGCATTTGGATGAAATGCCAC
TAATGATGTCTGAAGAAGGCTTTGAGAATGAGGAAAGTGATTACCACACCTTACCACGAGCCAGGATAATGCAAAGGAAAAGAGGACTGG
AGTGGTTTGTCTGTGATGGCTGGAAGTTCCTCTGTACCAGTTGCTGTGGTTGGCTGATAAATATTTGTCGAAGAAAGAAAGAGCTGAAAG
CTCGCACAGTATGGCTTGGATGTCCTGAAAAGTGTGAAGAAAAACATCCCAGGAATTCTATAAAAAATCAAAAATACAATGTGTTTACCT
TTATACCTGGGGTTTTGTATGAACAATTCAAGTTTTTCTTGAATCTCTATTTTCTAGTAATATCCTGCTCACAGTTTGTACCAGCATTGA
AAATAGGCTATCTCTACACCTACTGGGCTCCTCTGGGATTTGTCTTGGCTGTTACTATGACACGGGAAGCAATTGATGAATTTCGGCGTT
TTCAGCGTGACAAGGAAGTGAATTCACAACTATATAGCAAGCTTACAGTAAGAGGTAAAGTGCAAGTTAAGAGTTCAGACATACAAGTTG
GAGACCTCATCATAGTGGAAAAGAATCAAAGAATTCCATCGGACATGGTGTTTCTTAGGACTTCAGAAAAAGCAGGTTCGTGTTTTATTC
GAACTGATCAACTAGATGGTGAAACTGACTGGAAGCTGAAGGTGGCAGTGAGCTGCACGCAACAGCTGCCGGCTCTGGGGGACCTTTTTT
CTATCAGTGCTTATGTTTATGCTCAGAAACCACAAATGGACATTCACAGTTTCGAAGGCACATTTACCAGGGAAGACAGTGACCCGCCCA
TTCATGAAAGTCTCAGCATAGAAAATACATTGTGGGCAAGCACCATTGTTGCATCAGGTACTGTAATAGGTGTTGTCATTTATACCGGAA
AAGAGACTCGAAGTGTAATGAACACATCCAATCCAAAAAATAAGGTTGGTTTGTTGGACCTTGAACTCAATCGGCTGACGAAAGCGCTAT
TTTTGGCTTTAGTTGCTCTTTCCATTGTTATGGTAACCTTACAAGGATTTGTGGGTCCATGGTACCGCAATCTTTTTCGGTTCCTTCTCC
TCTTTTCTTACATCATTCCCATAAGTTTGCGTGTGAACTTGGACATGGGCAAAGCGGTGTATGGATGGATGATGATGAAAGATGAGAACA
TCCCTGGCACGGTCGTTCGGACCAGCACTATCCCAGAGGAACTTGGGCGCCTGGTGTATTTATTGACAGACAAAACAGGAACCCTCACCC
AGAATGAAATGATATTTAAGCGGCTGCACCTGGGCACCGTGTCCTATGGCGCCGACACGATGGATGAGATCCAGAGCCATGTCAGGGACT
CCTACTCACAGATGCAGTCTCAAGCTGGTGGAAACAATACTGGTTCAACTCCACTAAGAAAAGCCCAATCTTCAGCTCCCAAAGTTAGGA
AAAGTGTCAGTAGTCGAATCCATGAAGCCGTGAAAGCCATCGTGCTGTGTCACAACGTGACCCCCGTGTATGAGTCTCGGGCCGGCGTTA
CTGAGGAGACTGAGTTCGCAGAGGCTGACCAAGACTTCAGTGATGAGAATCGCACCTACCAGGCTTCCAGCCCGGATGAGGTCGCTCTGG
TGCAGTGGACAGAGAGTGTGGGCCTCACGCTGGTCAGCAGGGACCTCACCTCCATGCAGCTGAAGACCCCCAGTGGCCAGGTCCTCAGCT
TCTGCATTCTGCAGCTGTTTCCCTTCACCTCCGAGAGCAAGCGGATGGGCGTCATCGTCAGGGATGAATCCACGGCAGAAATCACATTCT
ACATGAAGGGCGCTGACGTGGCCATGTCTCCTATCGTGCAGTATAATGACTGGCTGGAAGAGGAGTGCGGAAACATGGCTCGCGAAGGAC
TGCGGACCCTCGTGGTTGCAAAGAAGGCGTTGACAGAGGAGCAGTACCAGGACTTTGAGAGCCGATACACTCAAGCCAAGCTGAGCATGC
ACGACAGGTCCCTCAAGGTGGCCGCGGTAGTCGAGAGCCTGGAGAGGGAGATGGAACTGCTGTGCCTCACCGGCGTGGAGGACCAGCTGC
AGGCAGACGTGCGGCCCACGCTGGAGATGCTGCGCAACGCCGGGATCAAGATATGGATGCTAACAGGCGATAAACTCGAGACAGCTACCT
GCATTGCCAAAAGTTCACATCTCGTGTCTAGAACACAAGATATTCATATTTTCAGACAGGTAACCAGTCGGGGAGAGGCACATTTGGAGC
TGAATGCATTTCGAAGGAAGCATGATTGTGCACTAGTCATATCTGGGGACTCTCTGGAGGTTTGTCTAAAGTACTACGAGCATGAATTTG
TGGAGCTGGCCTGCCAGTGCCCTGCCGTGGTTTGCTGCCGCTGCTCACCCACCCAGAAGGCCCGCATTGTGACACTGCTGCAGCAGCACA
CAGGGAGACGCACCTGCGCCATCGGTGATGGAGGAAATGATGTCAGCATGATTCAGGCAGCAGACTGTGGGATTGGGATTGAGGGAAAGG
AGGGTAAACAGGCCTCGCTGGCGGCCGACTTCTCCATCACGCAGTTCCGGCACATAGGCAGGCTGCTCATGGTGCACGGGCGGAACAGCT
ACAAGAGGTCGGCGGCACTCGGCCAGTTCGTCATGCACAGGGGCCTTATCATCTCCACCATGCAGGCTGTGTTTTCCTCAGTCTTCTACT
TCGCATCCGTCCCTTTGTATCAGGGCTTCCTCATGGTGGGGTATGCCACCATATACACCATGTTCCCAGTGTTCTCCTTAGTGCTGGACC
AGGACGTGAAGCCAGAGATGGCGATGCTCTACCCGGAGCTGTACAAGGACCTCACCAAGGGAAGATCCTTGTCCTTCAAAACCTTCCTCA
TCTGGGTTTTAATAAGTATTTACCAAGATATTTTGAGAGCCAGGAGAGACACAAAACGCTTTTCTCAATGAAAGAAAGCAGGCTTCAGCT
ATAAAAAAAGAGGAGTTAGTGGCCAGATCGGAAACACATGCTGCCGGGCATTCTCAGGAGAAGACACATAGCCGAGAGAAGAGTAGCCAG
GAGAGTGGAGAGGAGACAGGGAGCCAGGAGAATCACCCCCAGGAGTCTAAAGGCCAACCCCGAAGCCAGGAAGAATCTGAGGAAGGTGAG
GAAGATGCCACCTCTGAGGTGGACAAACGACGCACGAGGCCCAGACACCACCACGGGAGGAGCAGGCCCGACAGGTCCTCTCAAGGAGGG
AGTCTTCCCTCTGAGGAAAAGGGACACCCCCAGGAGGAATCTGAGGAGTCAAACGTCAGCATGGCCAGTTTAGGGGAAAAGAGGGACCAC
CATTCAACCCACTACAGGGCTTCAGAGGAAGAACCTGAATATGGAGAAGAAATAAAGGGTTATCCAGGCGTCCAGGCCCCTGAGGACCTG
GAGTGGGAGCGCTATAGGGGCAGAGGAAGTGAAGAATACAGGGCTCCAAGACCTCAGAGTGAGGAGAGTTGGGATGAGGAGGACAAGAGA
AACTACCCCAGCTTAGAGCTTGATAAGATGGCACATGGATATGGTGAAGAAAGTGAGGAAGAGAGGGGCCTTGAGCCGGGAAAGGGACGC
CATCACAGAGGCAGGGGAGGGGAGCCACGTGCCTATTTCATGTCTGACACCAGAGAAGAGAAAAGGTTCTTGGGTGAAGGACACCACCGT
GTCCAAGAAAACCAGATGGACAAGGCAAGGAGGCATCCACAAGGTGCGTGGAAAGAGCTGGACAGAAATTATCTCAACTACGGTGAGGAA
GGAGCCCCAGGGAAGTGGCAGCAGCAGGGAGACCTGCAGGACACTAAAGAAAACAGGGAGGAAGCTAGGTTTCAAGATAAACAATATAGC
TCCCATCACACAGCTGAAAAGAGGAAGAGATTAGGGGAACTGTTCAACCCATACTACGACCCTCTCCAGTGGAAGAGCAGCCATTTTGAA
AGAAGAGACAACATGAATGACAATTTTCTCGAGGGTGAGGAGGAAAATGAGCTGACCTTGAACGAGAAGAATTTCTTCCCAGAATACAAC
TATGACTGGTGGGAGAAAAAGCCCTTCTCTGAGGATGTGAACTGGGGGTATGAGAAGAGAAACCTCGCCAGGGTCCCCAAGCTGGACCTG
AAAAGGCAATATGACAGGGTGGCCCAACTGGACCAGCTCCTTCACTACAGGAAGAAGTCAGCTGAGTTTCCAGACTTCTATGATTCTGAG
GAGCCGGTGAGCACCCACCAGGAGGCAGAAAATGAAAAGGACAGGGCTGACCAGACAGTCCTGACAGAGGACGAGAAAAAAGAACTCGAA
AACTTGGCTGCAATGGATTTGGAACTACAGAAGATAGCTGAGAAATTCAGCCAAAGGGGCTGACTGTCATTGGAGCGGTGGGCACTGTTA
AGAAGCAGCCATCACATGATCTGTTTTTCACCACTTCACTGAAAGACACCATTTATCTACCCAAGGGCAGAAAGTAGAACTTACTATTCA
TTAAATGTTTGACACAATTGGAATTGTCTTTAATTTCTGTCAGAATGCTATTGAAAATGTGAATTGCATGACTTGTAGCATATTCTTTTC
TGCAAAATAGACATATTAACATGCTTATGACAATGACTGTGCTACTGTCTTTGGAAAAATGTTTGTCTCAGTTGGAAATAATAAAAGATT

>8296_8296_2_ATP9B-CHGB_ATP9B_chr18_77134093_ENST00000426216_CHGB_chr20_5903356_ENST00000378961_length(amino acids)=1037AA_BP=
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCD
GWKFLCTSCCGWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY
TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLD
GETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSV
MNTSNPKNKVGLLDLELNRLTKALFLALVALSIVMVTLQGFVGPWYRNLFRFLLLFSYIIPISLRVNLDMGKAVYGWMMMKDENIPGTVV
RTSTIPEELGRLVYLLTDKTGTLTQNEMIFKRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTPLRKAQSSAPKVRKSVSSR
IHEAVKAIVLCHNVTPVYESRAGVTEETEFAEADQDFSDENRTYQASSPDEVALVQWTESVGLTLVSRDLTSMQLKTPSGQVLSFCILQL
FPFTSESKRMGVIVRDESTAEITFYMKGADVAMSPIVQYNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDFESRYTQAKLSMHDRSLK
VAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSRGEAHLELNAFRR
KHDCALVISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQAS
LAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSLVLDQDVKPE

--------------------------------------------------------------
>8296_8296_3_ATP9B-CHGB_ATP9B_chr18_77134093_ENST00000543761_CHGB_chr20_5903356_ENST00000378961_length(transcript)=2855nt_BP=1075nt
GTATAATGACTGGCTGGAAGAGGAGTGCGGAAACATGGCTCGCGAAGGACTGCGGACCCTCGTGGTTGCAAAGAAGGCGTTGACAGAGGA
GCAGTACCAGGACTTTGAGAGCCGATACACTCAAGCCAAGCTGAGCATGCACGACAGGTCCCTCAAGGTGGCCGCGGTAGTCGAGAGCCT
GGAGAGGGAGATGGAACTGCTGTGCCTCACCGGCGTGGAGGACCAGCTGCAGGCAGACGTGCGGCCCACGCTGGAGATGCTGCGCAACGC
CGGGATCAAGATATGGATGCTAACAGGCGATAAACTCGAGACAGCTACCTGCATTGCCAAAAGTTCACATCTCGTGTCTAGAACACAAGA
TATTCATATTTTCAGACAGGTAACCAGTCGGGGAGAGGCACATTTGGAGCTGAATGCATTTCGAAGGAAGCATGATTGTGCACTAGTCAT
ATCTGGGGACTCTCTGGAGGTTTGTCTAAAGTACTACGAGCATGAATTTGTGGAGCTGGCCTGCCAGTGCCCTGCCGTGGTTTGCTGCCG
CTGCTCACCCACCCAGAAGGCCCGCATTGTGACACTGCTGCAGCAGCACACAGGGAGACGCACCTGCGCCATCGGTGATGGAGGAAATGA
TGTCAGCATGATTCAGGCAGCAGACTGTGGGATTGGGATTGAGGGAAAGGAGGGTAAACAGGCCTCGCTGGCGGCCGACTTCTCCATCAC
GCAGTTCCGGCACATAGGCAGGCTGCTCATGGTGCACGGGCGGAACAGCTACAAGAGGTCGGCGGCACTCGGCCAGTTCGTCATGCACAG
GGGCCTTATCATCTCCACCATGCAGGCTGTGTTTTCCTCAGTCTTCTACTTCGCATCCGTCCCTTTGTATCAGGGCTTCCTCATGGTGGG
GTATGCCACCATATACACCATGTTCCCAGTGTTCTCCTTAGTGCTGGACCAGGACGTGAAGCCAGAGATGGCGATGCTCTACCCGGAGCT
GTACAAGGACCTCACCAAGGGAAGATCCTTGTCCTTCAAAACCTTCCTCATCTGGGTTTTAATAAGTATTTACCAAGATATTTTGAGAGC
CAGGAGAGACACAAAACGCTTTTCTCAATGAAAGAAAGCAGGCTTCAGCTATAAAAAAAGAGGAGTTAGTGGCCAGATCGGAAACACATG
CTGCCGGGCATTCTCAGGAGAAGACACATAGCCGAGAGAAGAGTAGCCAGGAGAGTGGAGAGGAGACAGGGAGCCAGGAGAATCACCCCC
AGGAGTCTAAAGGCCAACCCCGAAGCCAGGAAGAATCTGAGGAAGGTGAGGAAGATGCCACCTCTGAGGTGGACAAACGACGCACGAGGC
CCAGACACCACCACGGGAGGAGCAGGCCCGACAGGTCCTCTCAAGGAGGGAGTCTTCCCTCTGAGGAAAAGGGACACCCCCAGGAGGAAT
CTGAGGAGTCAAACGTCAGCATGGCCAGTTTAGGGGAAAAGAGGGACCACCATTCAACCCACTACAGGGCTTCAGAGGAAGAACCTGAAT
ATGGAGAAGAAATAAAGGGTTATCCAGGCGTCCAGGCCCCTGAGGACCTGGAGTGGGAGCGCTATAGGGGCAGAGGAAGTGAAGAATACA
GGGCTCCAAGACCTCAGAGTGAGGAGAGTTGGGATGAGGAGGACAAGAGAAACTACCCCAGCTTAGAGCTTGATAAGATGGCACATGGAT
ATGGTGAAGAAAGTGAGGAAGAGAGGGGCCTTGAGCCGGGAAAGGGACGCCATCACAGAGGCAGGGGAGGGGAGCCACGTGCCTATTTCA
TGTCTGACACCAGAGAAGAGAAAAGGTTCTTGGGTGAAGGACACCACCGTGTCCAAGAAAACCAGATGGACAAGGCAAGGAGGCATCCAC
AAGGTGCGTGGAAAGAGCTGGACAGAAATTATCTCAACTACGGTGAGGAAGGAGCCCCAGGGAAGTGGCAGCAGCAGGGAGACCTGCAGG
ACACTAAAGAAAACAGGGAGGAAGCTAGGTTTCAAGATAAACAATATAGCTCCCATCACACAGCTGAAAAGAGGAAGAGATTAGGGGAAC
TGTTCAACCCATACTACGACCCTCTCCAGTGGAAGAGCAGCCATTTTGAAAGAAGAGACAACATGAATGACAATTTTCTCGAGGGTGAGG
AGGAAAATGAGCTGACCTTGAACGAGAAGAATTTCTTCCCAGAATACAACTATGACTGGTGGGAGAAAAAGCCCTTCTCTGAGGATGTGA
ACTGGGGGTATGAGAAGAGAAACCTCGCCAGGGTCCCCAAGCTGGACCTGAAAAGGCAATATGACAGGGTGGCCCAACTGGACCAGCTCC
TTCACTACAGGAAGAAGTCAGCTGAGTTTCCAGACTTCTATGATTCTGAGGAGCCGGTGAGCACCCACCAGGAGGCAGAAAATGAAAAGG
ACAGGGCTGACCAGACAGTCCTGACAGAGGACGAGAAAAAAGAACTCGAAAACTTGGCTGCAATGGATTTGGAACTACAGAAGATAGCTG
AGAAATTCAGCCAAAGGGGCTGACTGTCATTGGAGCGGTGGGCACTGTTAAGAAGCAGCCATCACATGATCTGTTTTTCACCACTTCACT
GAAAGACACCATTTATCTACCCAAGGGCAGAAAGTAGAACTTACTATTCATTAAATGTTTGACACAATTGGAATTGTCTTTAATTTCTGT
CAGAATGCTATTGAAAATGTGAATTGCATGACTTGTAGCATATTCTTTTCTGCAAAATAGACATATTAACATGCTTATGACAATGACTGT

>8296_8296_3_ATP9B-CHGB_ATP9B_chr18_77134093_ENST00000543761_CHGB_chr20_5903356_ENST00000378961_length(amino acids)=365AA_BP=
MEEECGNMAREGLRTLVVAKKALTEEQYQDFESRYTQAKLSMHDRSLKVAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKI
WMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPT
QKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLII
STMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSLVLDQDVKPEMAMLYPELYKDLTKGRSLSFKTFLIWVLISIYQDILRARRDT

--------------------------------------------------------------
>8296_8296_4_ATP9B-CHGB_ATP9B_chr18_77134094_ENST00000307671_CHGB_chr20_5903357_ENST00000378961_length(transcript)=4870nt_BP=3091nt
GGGGCGGTCGGAACATGGCGGACCAGATCCCGCTTTACCCGGTGCGTAGCGCAGCGGCGGCCGCAGCCAACCGCAAACGCGCGGCCTACT
ACAGCGCCGCGGGGCCCAGGCCGGGAGCCGACCGGCACAGCAGGTACCAGCTGGAGGATGAGTCTGCGCATTTGGATGAAATGCCACTAA
TGATGTCTGAAGAAGGCTTTGAGAATGAGGAAAGTGATTACCACACCTTACCACGAGCCAGGATAATGCAAAGGAAAAGAGGACTGGAGT
GGTTTGTCTGTGATGGCTGGAAGTTCCTCTGTACCAGTTGCTGTGGTTGGCTGATAAATATTTGTCGAAGAAAGAAAGAGCTGAAAGCTC
GCACAGTATGGCTTGGATGTCCTGAAAAGTGTGAAGAAAAACATCCCAGGAATTCTATAAAAAATCAAAAATACAATGTGTTTACCTTTA
TACCTGGGGTTTTGTATGAACAATTCAAGTTTTTCTTGAATCTCTATTTTCTAGTAATATCCTGCTCACAGTTTGTACCAGCATTGAAAA
TAGGCTATCTCTACACCTACTGGGCTCCTCTGGGATTTGTCTTGGCTGTTACTATGACACGGGAAGCAATTGATGAATTTCGGCGTTTTC
AGCGTGACAAGGAAGTGAATTCACAACTATATAGCAAGCTTACAGTAAGAGGTAAAGTGCAAGTTAAGAGTTCAGACATACAAGTTGGAG
ACCTCATCATAGTGGAAAAGAATCAAAGAATTCCATCGGACATGGTGTTTCTTAGGACTTCAGAAAAAGCAGGTTCGTGTTTTATTCGAA
CTGATCAACTAGATGGTGAAACTGACTGGAAGCTGAAGGTGGCAGTGAGCTGCACGCAACAGCTGCCGGCTCTGGGGGACCTTTTTTCTA
TCAGTGCTTATGTTTATGCTCAGAAACCACAAATGGACATTCACAGTTTCGAAGGCACATTTACCAGGGAAGACAGTGACCCGCCCATTC
ATGAAAGTCTCAGCATAGAAAATACATTGTGGGCAAGCACCATTGTTGCATCAGGTACTGTAATAGGTGTTGTCATTTATACCGGAAAAG
AGACTCGAAGTGTAATGAACACATCCAATCCAAAAAATAAGGTTGGTTTGTTGGACCTTGAACTCAATCGGCTGACGAAAGCGCTATTTT
TGGCTTTAGTTGCTCTTTCCATTGTTATGGTAACCTTACAAGGATTTGTGGGTCCATGGTACCGCAATCTTTTTCGGTTCCTTCTCCTCT
TTTCTTACATCATTCCCATAAGTTTGCGTGTGAACTTGGACATGGGCAAAGCGGTGTATGGATGGATGATGATGAAAGATGAGAACATCC
CTGGCACGGTCGTTCGGACCAGCACTATCCCAGAGGAACTTGGGCGCCTGGTGTATTTATTGACAGACAAAACAGGAACCCTCACCCAGA
ATGAAATGATATTTAAGCGGCTGCACCTGGGCACCGTGTCCTATGGCGCCGACACGATGGATGAGATCCAGAGCCATGTCAGGGACTCCT
ACTCACAGATGCAGTCTCAAGCTGGTGGAAACAATACTGGTTCAACTCCACTAAGAAAAGCCCAATCTTCAGCTCCCAAAGTTAGGAAAA
GTGTCAGTAGTCGAATCCATGAAGCCGTGAAAGCCATCGTGCTGTGTCACAACGTGACCCCCGTGTATGAGTCTCGGGCCGGCGTTACTG
AGGAGACTGAGTTCGCAGAGGCTGACCAAGACTTCAGTGATGAGAATCGCACCTACCAGGCTTCCAGCCCGGATGAGGTCGCTCTGGTGC
AGTGGACAGAGAGTGTGGGCCTCACGCTGGTCAGCAGGGACCTCACCTCCATGCAGCTGAAGACCCCCAGTGGCCAGGTCCTCAGCTTCT
GCATTCTGCAGCTGTTTCCCTTCACCTCCGAGAGCAAGCGGATGGGCGTCATCGTCAGGGATGAATCCACGGCAGAAATCACATTCTACA
TGAAGGGCGCTGACGTGGCCATGTCTCCTATCGTGCAGTATAATGACTGGCTGGAAGAGGAGTGCGGAAACATGGCTCGCGAAGGACTGC
GGACCCTCGTGGTTGCAAAGAAGGCGTTGACAGAGGAGCAGTACCAGGACTTTGAGAGCCGATACACTCAAGCCAAGCTGAGCATGCACG
ACAGGTCCCTCAAGGTGGCCGCGGTAGTCGAGAGCCTGGAGAGGGAGATGGAACTGCTGTGCCTCACCGGCGTGGAGGACCAGCTGCAGG
CAGACGTGCGGCCCACGCTGGAGATGCTGCGCAACGCCGGGATCAAGATATGGATGCTAACAGGCGATAAACTCGAGACAGCTACCTGCA
TTGCCAAAAGTTCACATCTCGTGTCTAGAACACAAGATATTCATATTTTCAGACAGGTAACCAGTCGGGGAGAGGCACATTTGGAGCTGA
ATGCATTTCGAAGGAAGCATGATTGTGCACTAGTCATATCTGGGGACTCTCTGGAGGTTTGTCTAAAGTACTACGAGCATGAATTTGTGG
AGCTGGCCTGCCAGTGCCCTGCCGTGGTTTGCTGCCGCTGCTCACCCACCCAGAAGGCCCGCATTGTGACACTGCTGCAGCAGCACACAG
GGAGACGCACCTGCGCCATCGGTGATGGAGGAAATGATGTCAGCATGATTCAGGCAGCAGACTGTGGGATTGGGATTGAGGGAAAGGAGG
GTAAACAGGCCTCGCTGGCGGCCGACTTCTCCATCACGCAGTTCCGGCACATAGGCAGGCTGCTCATGGTGCACGGGCGGAACAGCTACA
AGAGGTCGGCGGCACTCGGCCAGTTCGTCATGCACAGGGGCCTTATCATCTCCACCATGCAGGCTGTGTTTTCCTCAGTCTTCTACTTCG
CATCCGTCCCTTTGTATCAGGGCTTCCTCATGGTGGGGTATGCCACCATATACACCATGTTCCCAGTGTTCTCCTTAGTGCTGGACCAGG
ACGTGAAGCCAGAGATGGCGATGCTCTACCCGGAGCTGTACAAGGACCTCACCAAGGGAAGATCCTTGTCCTTCAAAACCTTCCTCATCT
GGGTTTTAATAAGTATTTACCAAGTATTTTGGAGCCAGGAGAGACACAAAACGCTTTTCTCAATGAAAGAAAGCAGGCTTCAGCTATAAA
AAAAGAGGAGTTAGTGGCCAGATCGGAAACACATGCTGCCGGGCATTCTCAGGAGAAGACACATAGCCGAGAGAAGAGTAGCCAGGAGAG
TGGAGAGGAGACAGGGAGCCAGGAGAATCACCCCCAGGAGTCTAAAGGCCAACCCCGAAGCCAGGAAGAATCTGAGGAAGGTGAGGAAGA
TGCCACCTCTGAGGTGGACAAACGACGCACGAGGCCCAGACACCACCACGGGAGGAGCAGGCCCGACAGGTCCTCTCAAGGAGGGAGTCT
TCCCTCTGAGGAAAAGGGACACCCCCAGGAGGAATCTGAGGAGTCAAACGTCAGCATGGCCAGTTTAGGGGAAAAGAGGGACCACCATTC
AACCCACTACAGGGCTTCAGAGGAAGAACCTGAATATGGAGAAGAAATAAAGGGTTATCCAGGCGTCCAGGCCCCTGAGGACCTGGAGTG
GGAGCGCTATAGGGGCAGAGGAAGTGAAGAATACAGGGCTCCAAGACCTCAGAGTGAGGAGAGTTGGGATGAGGAGGACAAGAGAAACTA
CCCCAGCTTAGAGCTTGATAAGATGGCACATGGATATGGTGAAGAAAGTGAGGAAGAGAGGGGCCTTGAGCCGGGAAAGGGACGCCATCA
CAGAGGCAGGGGAGGGGAGCCACGTGCCTATTTCATGTCTGACACCAGAGAAGAGAAAAGGTTCTTGGGTGAAGGACACCACCGTGTCCA
AGAAAACCAGATGGACAAGGCAAGGAGGCATCCACAAGGTGCGTGGAAAGAGCTGGACAGAAATTATCTCAACTACGGTGAGGAAGGAGC
CCCAGGGAAGTGGCAGCAGCAGGGAGACCTGCAGGACACTAAAGAAAACAGGGAGGAAGCTAGGTTTCAAGATAAACAATATAGCTCCCA
TCACACAGCTGAAAAGAGGAAGAGATTAGGGGAACTGTTCAACCCATACTACGACCCTCTCCAGTGGAAGAGCAGCCATTTTGAAAGAAG
AGACAACATGAATGACAATTTTCTCGAGGGTGAGGAGGAAAATGAGCTGACCTTGAACGAGAAGAATTTCTTCCCAGAATACAACTATGA
CTGGTGGGAGAAAAAGCCCTTCTCTGAGGATGTGAACTGGGGGTATGAGAAGAGAAACCTCGCCAGGGTCCCCAAGCTGGACCTGAAAAG
GCAATATGACAGGGTGGCCCAACTGGACCAGCTCCTTCACTACAGGAAGAAGTCAGCTGAGTTTCCAGACTTCTATGATTCTGAGGAGCC
GGTGAGCACCCACCAGGAGGCAGAAAATGAAAAGGACAGGGCTGACCAGACAGTCCTGACAGAGGACGAGAAAAAAGAACTCGAAAACTT
GGCTGCAATGGATTTGGAACTACAGAAGATAGCTGAGAAATTCAGCCAAAGGGGCTGACTGTCATTGGAGCGGTGGGCACTGTTAAGAAG
CAGCCATCACATGATCTGTTTTTCACCACTTCACTGAAAGACACCATTTATCTACCCAAGGGCAGAAAGTAGAACTTACTATTCATTAAA
TGTTTGACACAATTGGAATTGTCTTTAATTTCTGTCAGAATGCTATTGAAAATGTGAATTGCATGACTTGTAGCATATTCTTTTCTGCAA
AATAGACATATTAACATGCTTATGACAATGACTGTGCTACTGTCTTTGGAAAAATGTTTGTCTCAGTTGGAAATAATAAAAGATTCACCT

>8296_8296_4_ATP9B-CHGB_ATP9B_chr18_77134094_ENST00000307671_CHGB_chr20_5903357_ENST00000378961_length(amino acids)=1044AA_BP=1026
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCD
GWKFLCTSCCGWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY
TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLD
GETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSV
MNTSNPKNKVGLLDLELNRLTKALFLALVALSIVMVTLQGFVGPWYRNLFRFLLLFSYIIPISLRVNLDMGKAVYGWMMMKDENIPGTVV
RTSTIPEELGRLVYLLTDKTGTLTQNEMIFKRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTPLRKAQSSAPKVRKSVSSR
IHEAVKAIVLCHNVTPVYESRAGVTEETEFAEADQDFSDENRTYQASSPDEVALVQWTESVGLTLVSRDLTSMQLKTPSGQVLSFCILQL
FPFTSESKRMGVIVRDESTAEITFYMKGADVAMSPIVQYNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDFESRYTQAKLSMHDRSLK
VAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSRGEAHLELNAFRR
KHDCALVISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQAS
LAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSLVLDQDVKPE

--------------------------------------------------------------
>8296_8296_5_ATP9B-CHGB_ATP9B_chr18_77134094_ENST00000426216_CHGB_chr20_5903357_ENST00000378961_length(transcript)=4873nt_BP=3094nt
AAAGGGGCGGTCGGAACATGGCGGACCAGATCCCGCTTTACCCGGTGCGTAGCGCAGCGGCGGCCGCAGCCAACCGCAAACGCGCGGCCT
ACTACAGCGCCGCGGGGCCCAGGCCGGGAGCCGACCGGCACAGCAGGTACCAGCTGGAGGATGAGTCTGCGCATTTGGATGAAATGCCAC
TAATGATGTCTGAAGAAGGCTTTGAGAATGAGGAAAGTGATTACCACACCTTACCACGAGCCAGGATAATGCAAAGGAAAAGAGGACTGG
AGTGGTTTGTCTGTGATGGCTGGAAGTTCCTCTGTACCAGTTGCTGTGGTTGGCTGATAAATATTTGTCGAAGAAAGAAAGAGCTGAAAG
CTCGCACAGTATGGCTTGGATGTCCTGAAAAGTGTGAAGAAAAACATCCCAGGAATTCTATAAAAAATCAAAAATACAATGTGTTTACCT
TTATACCTGGGGTTTTGTATGAACAATTCAAGTTTTTCTTGAATCTCTATTTTCTAGTAATATCCTGCTCACAGTTTGTACCAGCATTGA
AAATAGGCTATCTCTACACCTACTGGGCTCCTCTGGGATTTGTCTTGGCTGTTACTATGACACGGGAAGCAATTGATGAATTTCGGCGTT
TTCAGCGTGACAAGGAAGTGAATTCACAACTATATAGCAAGCTTACAGTAAGAGGTAAAGTGCAAGTTAAGAGTTCAGACATACAAGTTG
GAGACCTCATCATAGTGGAAAAGAATCAAAGAATTCCATCGGACATGGTGTTTCTTAGGACTTCAGAAAAAGCAGGTTCGTGTTTTATTC
GAACTGATCAACTAGATGGTGAAACTGACTGGAAGCTGAAGGTGGCAGTGAGCTGCACGCAACAGCTGCCGGCTCTGGGGGACCTTTTTT
CTATCAGTGCTTATGTTTATGCTCAGAAACCACAAATGGACATTCACAGTTTCGAAGGCACATTTACCAGGGAAGACAGTGACCCGCCCA
TTCATGAAAGTCTCAGCATAGAAAATACATTGTGGGCAAGCACCATTGTTGCATCAGGTACTGTAATAGGTGTTGTCATTTATACCGGAA
AAGAGACTCGAAGTGTAATGAACACATCCAATCCAAAAAATAAGGTTGGTTTGTTGGACCTTGAACTCAATCGGCTGACGAAAGCGCTAT
TTTTGGCTTTAGTTGCTCTTTCCATTGTTATGGTAACCTTACAAGGATTTGTGGGTCCATGGTACCGCAATCTTTTTCGGTTCCTTCTCC
TCTTTTCTTACATCATTCCCATAAGTTTGCGTGTGAACTTGGACATGGGCAAAGCGGTGTATGGATGGATGATGATGAAAGATGAGAACA
TCCCTGGCACGGTCGTTCGGACCAGCACTATCCCAGAGGAACTTGGGCGCCTGGTGTATTTATTGACAGACAAAACAGGAACCCTCACCC
AGAATGAAATGATATTTAAGCGGCTGCACCTGGGCACCGTGTCCTATGGCGCCGACACGATGGATGAGATCCAGAGCCATGTCAGGGACT
CCTACTCACAGATGCAGTCTCAAGCTGGTGGAAACAATACTGGTTCAACTCCACTAAGAAAAGCCCAATCTTCAGCTCCCAAAGTTAGGA
AAAGTGTCAGTAGTCGAATCCATGAAGCCGTGAAAGCCATCGTGCTGTGTCACAACGTGACCCCCGTGTATGAGTCTCGGGCCGGCGTTA
CTGAGGAGACTGAGTTCGCAGAGGCTGACCAAGACTTCAGTGATGAGAATCGCACCTACCAGGCTTCCAGCCCGGATGAGGTCGCTCTGG
TGCAGTGGACAGAGAGTGTGGGCCTCACGCTGGTCAGCAGGGACCTCACCTCCATGCAGCTGAAGACCCCCAGTGGCCAGGTCCTCAGCT
TCTGCATTCTGCAGCTGTTTCCCTTCACCTCCGAGAGCAAGCGGATGGGCGTCATCGTCAGGGATGAATCCACGGCAGAAATCACATTCT
ACATGAAGGGCGCTGACGTGGCCATGTCTCCTATCGTGCAGTATAATGACTGGCTGGAAGAGGAGTGCGGAAACATGGCTCGCGAAGGAC
TGCGGACCCTCGTGGTTGCAAAGAAGGCGTTGACAGAGGAGCAGTACCAGGACTTTGAGAGCCGATACACTCAAGCCAAGCTGAGCATGC
ACGACAGGTCCCTCAAGGTGGCCGCGGTAGTCGAGAGCCTGGAGAGGGAGATGGAACTGCTGTGCCTCACCGGCGTGGAGGACCAGCTGC
AGGCAGACGTGCGGCCCACGCTGGAGATGCTGCGCAACGCCGGGATCAAGATATGGATGCTAACAGGCGATAAACTCGAGACAGCTACCT
GCATTGCCAAAAGTTCACATCTCGTGTCTAGAACACAAGATATTCATATTTTCAGACAGGTAACCAGTCGGGGAGAGGCACATTTGGAGC
TGAATGCATTTCGAAGGAAGCATGATTGTGCACTAGTCATATCTGGGGACTCTCTGGAGGTTTGTCTAAAGTACTACGAGCATGAATTTG
TGGAGCTGGCCTGCCAGTGCCCTGCCGTGGTTTGCTGCCGCTGCTCACCCACCCAGAAGGCCCGCATTGTGACACTGCTGCAGCAGCACA
CAGGGAGACGCACCTGCGCCATCGGTGATGGAGGAAATGATGTCAGCATGATTCAGGCAGCAGACTGTGGGATTGGGATTGAGGGAAAGG
AGGGTAAACAGGCCTCGCTGGCGGCCGACTTCTCCATCACGCAGTTCCGGCACATAGGCAGGCTGCTCATGGTGCACGGGCGGAACAGCT
ACAAGAGGTCGGCGGCACTCGGCCAGTTCGTCATGCACAGGGGCCTTATCATCTCCACCATGCAGGCTGTGTTTTCCTCAGTCTTCTACT
TCGCATCCGTCCCTTTGTATCAGGGCTTCCTCATGGTGGGGTATGCCACCATATACACCATGTTCCCAGTGTTCTCCTTAGTGCTGGACC
AGGACGTGAAGCCAGAGATGGCGATGCTCTACCCGGAGCTGTACAAGGACCTCACCAAGGGAAGATCCTTGTCCTTCAAAACCTTCCTCA
TCTGGGTTTTAATAAGTATTTACCAAGTATTTTGGAGCCAGGAGAGACACAAAACGCTTTTCTCAATGAAAGAAAGCAGGCTTCAGCTAT
AAAAAAAGAGGAGTTAGTGGCCAGATCGGAAACACATGCTGCCGGGCATTCTCAGGAGAAGACACATAGCCGAGAGAAGAGTAGCCAGGA
GAGTGGAGAGGAGACAGGGAGCCAGGAGAATCACCCCCAGGAGTCTAAAGGCCAACCCCGAAGCCAGGAAGAATCTGAGGAAGGTGAGGA
AGATGCCACCTCTGAGGTGGACAAACGACGCACGAGGCCCAGACACCACCACGGGAGGAGCAGGCCCGACAGGTCCTCTCAAGGAGGGAG
TCTTCCCTCTGAGGAAAAGGGACACCCCCAGGAGGAATCTGAGGAGTCAAACGTCAGCATGGCCAGTTTAGGGGAAAAGAGGGACCACCA
TTCAACCCACTACAGGGCTTCAGAGGAAGAACCTGAATATGGAGAAGAAATAAAGGGTTATCCAGGCGTCCAGGCCCCTGAGGACCTGGA
GTGGGAGCGCTATAGGGGCAGAGGAAGTGAAGAATACAGGGCTCCAAGACCTCAGAGTGAGGAGAGTTGGGATGAGGAGGACAAGAGAAA
CTACCCCAGCTTAGAGCTTGATAAGATGGCACATGGATATGGTGAAGAAAGTGAGGAAGAGAGGGGCCTTGAGCCGGGAAAGGGACGCCA
TCACAGAGGCAGGGGAGGGGAGCCACGTGCCTATTTCATGTCTGACACCAGAGAAGAGAAAAGGTTCTTGGGTGAAGGACACCACCGTGT
CCAAGAAAACCAGATGGACAAGGCAAGGAGGCATCCACAAGGTGCGTGGAAAGAGCTGGACAGAAATTATCTCAACTACGGTGAGGAAGG
AGCCCCAGGGAAGTGGCAGCAGCAGGGAGACCTGCAGGACACTAAAGAAAACAGGGAGGAAGCTAGGTTTCAAGATAAACAATATAGCTC
CCATCACACAGCTGAAAAGAGGAAGAGATTAGGGGAACTGTTCAACCCATACTACGACCCTCTCCAGTGGAAGAGCAGCCATTTTGAAAG
AAGAGACAACATGAATGACAATTTTCTCGAGGGTGAGGAGGAAAATGAGCTGACCTTGAACGAGAAGAATTTCTTCCCAGAATACAACTA
TGACTGGTGGGAGAAAAAGCCCTTCTCTGAGGATGTGAACTGGGGGTATGAGAAGAGAAACCTCGCCAGGGTCCCCAAGCTGGACCTGAA
AAGGCAATATGACAGGGTGGCCCAACTGGACCAGCTCCTTCACTACAGGAAGAAGTCAGCTGAGTTTCCAGACTTCTATGATTCTGAGGA
GCCGGTGAGCACCCACCAGGAGGCAGAAAATGAAAAGGACAGGGCTGACCAGACAGTCCTGACAGAGGACGAGAAAAAAGAACTCGAAAA
CTTGGCTGCAATGGATTTGGAACTACAGAAGATAGCTGAGAAATTCAGCCAAAGGGGCTGACTGTCATTGGAGCGGTGGGCACTGTTAAG
AAGCAGCCATCACATGATCTGTTTTTCACCACTTCACTGAAAGACACCATTTATCTACCCAAGGGCAGAAAGTAGAACTTACTATTCATT
AAATGTTTGACACAATTGGAATTGTCTTTAATTTCTGTCAGAATGCTATTGAAAATGTGAATTGCATGACTTGTAGCATATTCTTTTCTG
CAAAATAGACATATTAACATGCTTATGACAATGACTGTGCTACTGTCTTTGGAAAAATGTTTGTCTCAGTTGGAAATAATAAAAGATTCA

>8296_8296_5_ATP9B-CHGB_ATP9B_chr18_77134094_ENST00000426216_CHGB_chr20_5903357_ENST00000378961_length(amino acids)=1044AA_BP=1026
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCD
GWKFLCTSCCGWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY
TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLD
GETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSV
MNTSNPKNKVGLLDLELNRLTKALFLALVALSIVMVTLQGFVGPWYRNLFRFLLLFSYIIPISLRVNLDMGKAVYGWMMMKDENIPGTVV
RTSTIPEELGRLVYLLTDKTGTLTQNEMIFKRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTPLRKAQSSAPKVRKSVSSR
IHEAVKAIVLCHNVTPVYESRAGVTEETEFAEADQDFSDENRTYQASSPDEVALVQWTESVGLTLVSRDLTSMQLKTPSGQVLSFCILQL
FPFTSESKRMGVIVRDESTAEITFYMKGADVAMSPIVQYNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDFESRYTQAKLSMHDRSLK
VAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSRGEAHLELNAFRR
KHDCALVISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQAS
LAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSLVLDQDVKPE

--------------------------------------------------------------
>8296_8296_6_ATP9B-CHGB_ATP9B_chr18_77134094_ENST00000543761_CHGB_chr20_5903357_ENST00000378961_length(transcript)=2853nt_BP=1074nt
GTATAATGACTGGCTGGAAGAGGAGTGCGGAAACATGGCTCGCGAAGGACTGCGGACCCTCGTGGTTGCAAAGAAGGCGTTGACAGAGGA
GCAGTACCAGGACTTTGAGAGCCGATACACTCAAGCCAAGCTGAGCATGCACGACAGGTCCCTCAAGGTGGCCGCGGTAGTCGAGAGCCT
GGAGAGGGAGATGGAACTGCTGTGCCTCACCGGCGTGGAGGACCAGCTGCAGGCAGACGTGCGGCCCACGCTGGAGATGCTGCGCAACGC
CGGGATCAAGATATGGATGCTAACAGGCGATAAACTCGAGACAGCTACCTGCATTGCCAAAAGTTCACATCTCGTGTCTAGAACACAAGA
TATTCATATTTTCAGACAGGTAACCAGTCGGGGAGAGGCACATTTGGAGCTGAATGCATTTCGAAGGAAGCATGATTGTGCACTAGTCAT
ATCTGGGGACTCTCTGGAGGTTTGTCTAAAGTACTACGAGCATGAATTTGTGGAGCTGGCCTGCCAGTGCCCTGCCGTGGTTTGCTGCCG
CTGCTCACCCACCCAGAAGGCCCGCATTGTGACACTGCTGCAGCAGCACACAGGGAGACGCACCTGCGCCATCGGTGATGGAGGAAATGA
TGTCAGCATGATTCAGGCAGCAGACTGTGGGATTGGGATTGAGGGAAAGGAGGGTAAACAGGCCTCGCTGGCGGCCGACTTCTCCATCAC
GCAGTTCCGGCACATAGGCAGGCTGCTCATGGTGCACGGGCGGAACAGCTACAAGAGGTCGGCGGCACTCGGCCAGTTCGTCATGCACAG
GGGCCTTATCATCTCCACCATGCAGGCTGTGTTTTCCTCAGTCTTCTACTTCGCATCCGTCCCTTTGTATCAGGGCTTCCTCATGGTGGG
GTATGCCACCATATACACCATGTTCCCAGTGTTCTCCTTAGTGCTGGACCAGGACGTGAAGCCAGAGATGGCGATGCTCTACCCGGAGCT
GTACAAGGACCTCACCAAGGGAAGATCCTTGTCCTTCAAAACCTTCCTCATCTGGGTTTTAATAAGTATTTACCAAGTATTTTGGAGCCA
GGAGAGACACAAAACGCTTTTCTCAATGAAAGAAAGCAGGCTTCAGCTATAAAAAAAGAGGAGTTAGTGGCCAGATCGGAAACACATGCT
GCCGGGCATTCTCAGGAGAAGACACATAGCCGAGAGAAGAGTAGCCAGGAGAGTGGAGAGGAGACAGGGAGCCAGGAGAATCACCCCCAG
GAGTCTAAAGGCCAACCCCGAAGCCAGGAAGAATCTGAGGAAGGTGAGGAAGATGCCACCTCTGAGGTGGACAAACGACGCACGAGGCCC
AGACACCACCACGGGAGGAGCAGGCCCGACAGGTCCTCTCAAGGAGGGAGTCTTCCCTCTGAGGAAAAGGGACACCCCCAGGAGGAATCT
GAGGAGTCAAACGTCAGCATGGCCAGTTTAGGGGAAAAGAGGGACCACCATTCAACCCACTACAGGGCTTCAGAGGAAGAACCTGAATAT
GGAGAAGAAATAAAGGGTTATCCAGGCGTCCAGGCCCCTGAGGACCTGGAGTGGGAGCGCTATAGGGGCAGAGGAAGTGAAGAATACAGG
GCTCCAAGACCTCAGAGTGAGGAGAGTTGGGATGAGGAGGACAAGAGAAACTACCCCAGCTTAGAGCTTGATAAGATGGCACATGGATAT
GGTGAAGAAAGTGAGGAAGAGAGGGGCCTTGAGCCGGGAAAGGGACGCCATCACAGAGGCAGGGGAGGGGAGCCACGTGCCTATTTCATG
TCTGACACCAGAGAAGAGAAAAGGTTCTTGGGTGAAGGACACCACCGTGTCCAAGAAAACCAGATGGACAAGGCAAGGAGGCATCCACAA
GGTGCGTGGAAAGAGCTGGACAGAAATTATCTCAACTACGGTGAGGAAGGAGCCCCAGGGAAGTGGCAGCAGCAGGGAGACCTGCAGGAC
ACTAAAGAAAACAGGGAGGAAGCTAGGTTTCAAGATAAACAATATAGCTCCCATCACACAGCTGAAAAGAGGAAGAGATTAGGGGAACTG
TTCAACCCATACTACGACCCTCTCCAGTGGAAGAGCAGCCATTTTGAAAGAAGAGACAACATGAATGACAATTTTCTCGAGGGTGAGGAG
GAAAATGAGCTGACCTTGAACGAGAAGAATTTCTTCCCAGAATACAACTATGACTGGTGGGAGAAAAAGCCCTTCTCTGAGGATGTGAAC
TGGGGGTATGAGAAGAGAAACCTCGCCAGGGTCCCCAAGCTGGACCTGAAAAGGCAATATGACAGGGTGGCCCAACTGGACCAGCTCCTT
CACTACAGGAAGAAGTCAGCTGAGTTTCCAGACTTCTATGATTCTGAGGAGCCGGTGAGCACCCACCAGGAGGCAGAAAATGAAAAGGAC
AGGGCTGACCAGACAGTCCTGACAGAGGACGAGAAAAAAGAACTCGAAAACTTGGCTGCAATGGATTTGGAACTACAGAAGATAGCTGAG
AAATTCAGCCAAAGGGGCTGACTGTCATTGGAGCGGTGGGCACTGTTAAGAAGCAGCCATCACATGATCTGTTTTTCACCACTTCACTGA
AAGACACCATTTATCTACCCAAGGGCAGAAAGTAGAACTTACTATTCATTAAATGTTTGACACAATTGGAATTGTCTTTAATTTCTGTCA
GAATGCTATTGAAAATGTGAATTGCATGACTTGTAGCATATTCTTTTCTGCAAAATAGACATATTAACATGCTTATGACAATGACTGTGC

>8296_8296_6_ATP9B-CHGB_ATP9B_chr18_77134094_ENST00000543761_CHGB_chr20_5903357_ENST00000378961_length(amino acids)=499AA_BP=11
MGFNKYLPSILEPGETQNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQESGEETGSQENHPQESKGQPRSQEESEEGEE
DATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRASEEEPEYGEEIKGYPGVQAPEDLE
WERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSLELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMSDTREEKRFLGEGHHRV
QENQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEARFQDKQYSSHHTAEKRKRLGELFNPYYDPLQWKSSHFER
RDNMNDNFLEGEEENELTLNEKNFFPEYNYDWWEKKPFSEDVNWGYEKRNLARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFYDSEE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATP9B-CHGB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP9B-CHGB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP9B-CHGB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP9BC0009171Cocaine Abuse1CTD_human
HgeneATP9BC0236736Cocaine-Related Disorders1CTD_human
HgeneATP9BC0600427Cocaine Dependence1CTD_human
TgeneC0036341Schizophrenia3PSYGENET
TgeneC0221765Chronic schizophrenia1PSYGENET