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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AGRN-PIEZO1 (FusionGDB2 ID:HG375790TG9780)

Fusion Gene Summary for AGRN-PIEZO1

check button Fusion gene summary
Fusion gene informationFusion gene name: AGRN-PIEZO1
Fusion gene ID: hg375790tg9780
HgeneTgene
Gene symbol

AGRN

PIEZO1

Gene ID

375790

9780

Gene nameagrinpiezo type mechanosensitive ion channel component 1
SynonymsAGRIN|CMS8|CMSPPDDHS|FAM38A|LMPH3|LMPHM6|Mib
Cytomap('AGRN')('PIEZO1')

1p36.33

16q24.3

Type of geneprotein-codingprotein-coding
Descriptionagrinagrin proteoglycanpiezo-type mechanosensitive ion channel component 1family with sequence similarity 38, member Amembrane protein induced by beta-amyloid treatment
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000477585, ENST00000379370, 
Fusion gene scores* DoF score14 X 7 X 10=9806 X 4 X 2=48
# samples 186
** MAII scorelog2(18/980*10)=-2.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AGRN [Title/Abstract] AND PIEZO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGRN(970704)-PIEZO1(88815887), # samples:1
Anticipated loss of major functional domain due to fusion event.AGRN-PIEZO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGRN-PIEZO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGRN-PIEZO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGRN-PIEZO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAGRN

GO:0043113

receptor clustering

15340048


check buttonFusion gene breakpoints across AGRN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PIEZO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-7808-01AAGRNchr1

970704

+PIEZO1chr16

88815887

-


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Fusion Gene ORF analysis for AGRN-PIEZO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000477585ENST00000301015AGRNchr1

970704

+PIEZO1chr16

88815887

-
3UTR-intronENST00000477585ENST00000327397AGRNchr1

970704

+PIEZO1chr16

88815887

-
5CDS-intronENST00000379370ENST00000327397AGRNchr1

970704

+PIEZO1chr16

88815887

-
In-frameENST00000379370ENST00000301015AGRNchr1

970704

+PIEZO1chr16

88815887

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379370AGRNchr1970704+ENST00000301015PIEZO1chr1688815887-83225615080622670

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379370ENST00000301015AGRNchr1970704+PIEZO1chr1688815887-0.0026099340.9973901

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Fusion Genomic Features for AGRN-PIEZO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AGRN-PIEZO1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:970704/chr16:88815887)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+33630_1571702046.0DomainNtA
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511339_1368212522.0Coiled coilOntology_term=ECO:0000255
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150512198_2431212522.0Topological domainExtracellular
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511043_1063212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511160_1180212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511184_1204212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051118_138212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511218_1240212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511247_1264212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511277_1297212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511678_1698212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511700_1720212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511734_1754212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051194_214212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150511962_1982212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150512003_2023212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150512032_2052212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150512061_2081212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150512100_2122212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150512129_2149212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150512177_2197212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051218_238212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150512432_2452212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051248_268212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST0000030101505127_47212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051302_322212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051428_448212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051460_480212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051514_534212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051579_599212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051602_622212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051629_649212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST0000030101505164_84212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051681_701212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051823_843212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051852_872212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051926_946212522.0TransmembraneHelical
TgenePIEZO1chr1:970704chr16:88815887ENST00000301015051987_1007212522.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361941_20091702046.0Calcium bindingOntology_term=ECO:0000250
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361058_10971702046.0Compositional biasNote=Gly/Ser-rich
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361254_13241702046.0Compositional biasNote=Ser/Thr-rich
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336671_6771702046.0Compositional biasNote=Gly/Ser-rich
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336974_10991702046.0Compositional biasNote=Ser/Thr-rich
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361130_12521702046.0DomainSEA
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361329_13671702046.0DomainEGF-like 1
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361372_15481702046.0DomainLaminin G-like 1
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361549_15861702046.0DomainEGF-like 2
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361588_16251702046.0DomainEGF-like 3
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361635_18221702046.0DomainLaminin G-like 2
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361818_18571702046.0DomainEGF-like 4
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+3361868_20651702046.0DomainLaminin G-like 3
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336191_2441702046.0DomainKazal-like 1
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336264_3191702046.0DomainKazal-like 2
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336337_3911702046.0DomainKazal-like 3
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336408_4631702046.0DomainKazal-like 4
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336484_5361702046.0DomainKazal-like 5
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336540_6011702046.0DomainKazal-like 6
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336607_6661702046.0DomainKazal-like 7
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336699_7521702046.0DomainKazal-like 8
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336793_8461702046.0DomainLaminin EGF-like 1
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336847_8931702046.0DomainLaminin EGF-like 2
HgeneAGRNchr1:970704chr16:88815887ENST00000379370+336917_9711702046.0DomainKazal-like 9
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150516_91212522.0Compositional biasNote=Leu-rich
TgenePIEZO1chr1:970704chr16:88815887ENST000003010150515_25212522.0TransmembraneHelical


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Fusion Gene Sequence for AGRN-PIEZO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3004_3004_1_AGRN-PIEZO1_AGRN_chr1_970704_ENST00000379370_PIEZO1_chr16_88815887_ENST00000301015_length(transcript)=8322nt_BP=561nt
CCCGTCCCCGGCGCGGCCCGCGCGCTCCTCCGCCGCCTCTCGCCTGCGCCATGGCCGGCCGGTCCCACCCGGGCCCGCTGCGGCCGCTGC
TGCCGCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGACATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGA
ACGTGGTGCTCACCGGGACGGTGGAGGAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACT
TGAAGGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTGGAGACCCCCTCATCTGTG
ACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCACCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGC
TCAACTCCAGCCTCATGCGGATCACCCTGCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGATAAACCCGGGACCCACTTCACTCCAG
TGCCTCCGACGCCTCCTGATGCCTGCCTGCTCCGCTTCAGCGGACTCTCGCTGGTCTACCTGCTCTTCCTGCTGCTGCTGCCCTGGTTCC
CCGGCCCCACCCGATGCGGCCTCCAAGGTCACACAGGCCGCCTCCTGCGGGCATTGCTGGGCCTCAGCCTGCTCTTCCTGGTGGCCCATC
TCGCCCTCCAGATCTGCCTGCATATTGTGCCCCGCCTGGACCAGCTCCTGGGACCCAGCTGCAGCCGCTGGGAGACCCTCTCGCGACACA
TAGGGGTCACAAGGCTGGACCTGAAGGACATCCCCAACGCCATCCGGCTGGTGGCCCCTGACCTGGGCATCTTGGTGGTCTCCTCTGTCT
GCCTCGGCATCTGCGGGCGCCTTGCAAGGAACACCCGGCAGAGCCCACATCCACGGGAGCTGGATGATGATGAGAGGGATGTGGATGCCA
GCCCGACGGCAGGGCTGCAGGAAGCAGCAACGCTGGCCCCTACACGGAGGTCACGGCTGGCCGCTCGTTTCCGAGTCACGGCCCACTGGC
TGCTGGTGGCGGCTGGGCGGGTCCTGGCCGTAACACTGCTTGCACTGGCAGGCATCGCCCACCCCTCGGCCCTCTCCAGTGTCTACCTGC
TGCTCTTCCTGGCCCTCTGCACCTGGTGGGCCTGCCACTTTCCCATCAGCACTCGGGGCTTCAGCAGACTCTGCGTCGCGGTGGGGTGCT
TCGGCGCCGGCCATCTCATCTGCCTCTACTGCTACCAGATGCCCTTGGCACAGGCTCTGCTCCCGCCTGCCGGCATCTGGGCTAGGGTGC
TGGGTCTCAAGGACTTCGTGGGTCCCACCAACTGCTCCAGCCCCCACGCGCTGGTCCTCAACACCGGCCTGGACTGGCCTGTGTATGCCA
GCCCCGGCGTCCTCCTGCTGCTGTGCTACGCCACGGCCTCTCTGCGCAAGCTCCGCGCGTACCGCCCCTCCGGCCAGAGGAAGGAGGCGG
CAAAGGGGTATGAGGCTCGGGAGCTGGAGCTAGCAGAGCTGGACCAGTGGCCCCAGGAACGGGAGTCTGACCAGCACGTGGTGCCCACAG
CACCCGACACCGAGGCTGATAACTGCATCGTGCACGAGCTGACCGGCCAGAGCTCCGTCCTGCGGCGGCCTGTGCGGCCCAAGCGGGCTG
AGCCCAGGGAGGCGTCTCCGCTCCACAGCCTGGGCCACCTCATCATGGACCAGAGCTATGTGTGCGCGCTCATTGCCATGATGGTATGGA
GCATCACCTACCACAGCTGGCTGACCTTCGTACTGCTGCTCTGGGCCTGCCTCATCTGGACGGTGCGCAGCCGCCACCAACTGGCCATGC
TGTGCTCGCCCTGCATCCTGCTGTATGGGATGACGCTGTGCTGCCTACGCTACGTGTGGGCCATGGACCTGCGCCCTGAGCTGCCCACCA
CCCTGGGCCCCGTCAGCCTGCGCCAGCTGGGGCTGGAGCACACCCGCTACCCCTGTCTGGACCTTGGTGCCATGTTGCTCTACACCCTGA
CCTTCTGGCTCCTGCTGCGCCAGTTTGTGAAAGAGAAGCTGCTGAAGTGGGCAGAGTCTCCAGCTGCGCTGACGGAGGTCACCGTGGCAG
ACACAGAGCCCACGCGGACGCAGACGCTGTTGCAGAGCCTGGGGGAGCTGGTGAAGGGCGTGTACGCCAAGTACTGGATCTATGTGTGTG
CTGGCATGTTCATCGTGGTCAGCTTCGCCGGCCGCCTCGTGGTCTACAAGATTGTCTACATGTTCCTCTTCCTGCTCTGCCTCACCCTCT
TCCAGGTCTACTACAGCCTGTGGCGGAAGCTGCTCAAGGCCTTCTGGTGGCTCGTGGTGGCCTACACCATGCTGGTCCTCATCGCCGTCT
ACACCTTCCAGTTCCAGGACTTCCCTGCCTACTGGCGCAACCTCACTGGCTTCACCGACGAGCAGCTGGGGGACCTGGGCCTGGAGCAGT
TCAGCGTGTCCGAGCTCTTCTCCAGCATCCTGGTGCCCGGCTTCTTCCTCCTGGCCTGCATCCTGCAGCTGCACTACTTCCACAGGCCCT
TCATGCAGCTCACCGACATGGAGCACGTGTCCCTGCCTGGCACGCGCCTCCCGCGCTGGGCTCACAGGCAGGATGCAGTGAGTGGGACCC
CACTGCTGCGGGAGGAGCAGCAGGAGCATCAGCAGCAGCAGCAGGAGGAGGAGGAGGAGGAGGAGGACTCCAGGGACGAGGGGCTGGGCG
TGGCCACTCCCCACCAGGCCACGCAGGTGCCTGAAGGGGCAGCCAAGTGGGGCCTGGTGGCTGAGCGGCTGCTGGAGCTGGCAGCCGGCT
TCTCGGACGTCCTCTCACGCGTGCAGGTGTTCCTGCGGCGGCTGCTGGAGCTTCACGTTTTCAAGCTGGTGGCCCTGTACACCGTCTGGG
TGGCCCTGAAGGAGGTGTCGGTGATGAACCTGCTGCTGGTGGTGCTGTGGGCCTTCGCCCTGCCCTACCCACGCTTCCGGCCCATGGCCT
CCTGCCTGTCCACCGTGTGGACCTGCGTCATCATCGTGTGTAAGATGCTGTACCAGCTCAAGGTTGTCAACCCCCAGGAGTATTCCAGCA
ACTGCACCGAGCCCTTCCCCAACAGCACCAACTTGCTGCCCACGGAGATCAGCCAGTCCCTGCTGTACCGGGGGCCCGTGGACCCTGCCA
ACTGGTTTGGGGTGCGGAAAGGGTTCCCCAACCTGGGCTACATCCAGAACCACCTGCAAGTGCTGCTGCTGCTGGTATTCGAGGCCATCG
TGTACCGGCGCCAGGAGCACTACCGCCGGCAGCACCAGCTGGCCCCGCTGCCTGCCCAGGCCGTGTTTGCCAGCGGCACCCGCCAGCAGC
TGGACCAGGATCTGCTCGGCTGCCTCAAGTACTTCATCAACTTCTTCTTCTACAAATTCGGGCTGGAGATCTGCTTCCTGATGGCCGTGA
ACGTGATCGGGCAGCGCATGAACTTTCTGGTGACCCTGCACGGTTGCTGGCTGGTGGCCATCCTCACCCGCAGGCACCGCCAGGCCATTG
CCCGCCTCTGGCCCAACTACTGCCTCTTCCTGGCGCTGTTCCTGCTGTACCAGTACCTGCTGTGCCTGGGGATGCCCCCGGCCCTGTGCA
TTGATTATCCCTGGCGCTGGAGCCGGGCCGTCCCCATGAACTCCGCACTCATCAAGTGGCTGTACCTGCCTGATTTCTTCCGGGCCCCCA
ACTCCACCAACCTCATCAGCGACTTTCTCCTGCTGCTGTGCGCCTCCCAGCAGTGGCAGGTGTTCTCAGCTGAGCGCACAGAGGAGTGGC
AGCGCATGGCTGGCGTCAACACCGACCGCCTGGAGCCGCTGCGGGGGGAGCCCAACCCCGTGCCCAACTTTATCCACTGCAGGTCCTACC
TTGACATGCTGAAGGTGGCCGTCTTCCGATACCTGTTCTGGCTGGTGCTGGTGGTGGTGTTTGTCACGGGGGCCACCCGCATCAGCATCT
TCGGGCTGGGCTACCTGCTGGCCTGCTTCTACCTGCTGCTCTTCGGCACGGCCCTGCTGCAGAGGGACACACGGGCCCGCCTCGTGCTGT
GGGACTGCCTCATTCTGTACAACGTCACCGTCATCATCTCCAAGAACATGCTGTCGCTCCTGGCCTGCGTCTTCGTGGAGCAGATGCAGA
CCGGCTTCTGCTGGGTCATCCAGCTCTTCAGCCTTGTATGCACCGTCAAGGGCTACTATGACCCCAAGGAGATGATGGACAGAGACCAGG
ACTGCCTGCTGCCTGTGGAGGAGGCTGGCATCATCTGGGACAGCGTCTGCTTCTTCTTCCTGCTGCTGCAGCGCCGCGTCTTCCTTAGCC
ATTACTACCTGCACGTCAGGGCCGACCTCCAGGCCACCGCCCTGCTAGCCTCCAGGGGCTTCGCCCTCTACAACGCTGCCAACCTCAAGA
GCATTGACTTTCACCGCAGGATAGAGGAGAAGTCCCTGGCCCAGCTGAAAAGACAGATGGAGCGTATCCGTGCCAAGCAGGAGAAGCACA
GGCAGGGCCGGGTGGACCGCAGTCGCCCCCAGGACACCCTGGGCCCCAAGGACCCCGGCCTGGAGCCAGGGCCCGACAGTCCAGGGGGCT
CCTCCCCGCCACGGAGGCAGTGGTGGCGGCCCTGGCTGGACCACGCCACAGTCATCCACTCCGGGGACTACTTCCTGTTTGAGTCCGACA
GTGAGGAAGAGGAGGAGGCTGTTCCTGAAGACCCGAGGCCGTCGGCACAGAGTGCCTTCCAGCTGGCGTACCAGGCATGGGTGACCAACG
CCCAGGCGGTGCTGAGGCGGCGGCAGCAGGAGCAGGAGCAGGCAAGGCAGGAACAGGCAGGACAGCTACCCACAGGAGGTGGTCCCAGCC
AGGAGGTGGAGCCAGCAGAGGGCCCCGAGGAGGCAGCGGCAGGCCGGAGCCATGTGGTGCAGAGGGTGCTGAGCACGGCGCAGTTCCTGT
GGATGCTGGGGCAGGCGCTAGTGGATGAGCTGACACGCTGGCTGCAGGAGTTCACCCGGCACCACGGCACCATGAGCGACGTGCTGCGGG
CAGAGCGCTACCTCCTCACACAGGAGCTCCTGCAGGGCGGCGAAGTGCACAGGGGCGTGCTGGATCAGCTGTACACAAGCCAGGCCGAGG
CCACGCTGCCAGGCCCCACCGAGGCCCCCAATGCCCCAAGCACCGTGTCCAGTGGGCTGGGCGCGGAGGAGCCACTCAGCAGCATGACAG
ACGACATGGGCAGCCCCCTGAGCACCGGCTACCACACGCGCAGTGGCAGTGAGGAGGCAGTCACCGACCCCGGGGAGCGTGAGGCTGGTG
CCTCTCTGTACCAGGGACTGATGCGGACGGCCAGCGAGCTGCTCCTGGACAGGCGCCTGCGCATCCCAGAGCTGGAGGAGGCAGAGCTGT
TTGCGGAGGGGCAGGGCCGGGCGCTGCGGCTGCTGCGGGCCGTGTACCAGTGTGTGGCCGCCCACTCGGAGCTGCTCTGCTACTTCATCA
TCATCCTCAACCACATGGTCACGGCCTCCGCCGGCTCGCTGGTGCTGCCCGTGCTCGTCTTCCTGTGGGCCATGCTGTCGATCCCGAGGC
CCAGCAAGCGCTTCTGGATGACGGCCATCGTCTTCACCGAGATCGCGGTGGTCGTCAAGTACCTGTTCCAGTTTGGGTTCTTCCCCTGGA
ACAGCCACGTGGTGCTGCGGCGCTACGAGAACAAGCCCTACTTCCCGCCCCGCATCCTGGGCCTGGAGAAGACTGACGGCTACATCAAGT
ACGACCTGGTGCAGCTCATGGCCCTTTTCTTCCACCGCTCCCAGCTGCTGTGCTATGGCCTCTGGGACCATGAGGAGGACTCACCATCCA
AGGAGCATGACAAGAGCGGCGAGGAGGAGCAGGGAGCCGAGGAGGGGCCAGGGGTGCCTGCGGCCACCACCGAAGACCACATTCAGGTGG
AAGCCAGGGTCGGACCCACGGACGGGACCCCAGAACCCCAAGTGGAGCTCAGGCCCCGTGATACGAGGCGCATCAGTCTACGTTTTAGAA
GAAGGAAGAAGGAGGGCCCAGCACGGAAAGGAGCGGCAGCCATCGAAGCTGAGGACAGGGAGGAAGAAGAGGGGGAGGAAGAGAAAGAGG
CCCCCACGGGGAGAGAGAAGAGGCCAAGCCGCTCTGGAGGAAGAGTAAGGGCGGCCGGGCGGCGGCTGCAGGGCTTCTGCCTGTCCCTGG
CCCAGGGCACATATCGGCCGCTACGGCGCTTCTTCCACGACATCCTGCACACCAAGTACCGCGCAGCCACCGACGTCTATGCCCTCATGT
TCCTGGCTGATGTTGTCGACTTCATCATCATCATTTTTGGCTTCTGGGCCTTTGGGAAGCACTCGGCGGCCACAGACATCACGTCCTCCC
TATCAGACGACCAGGTACCCGAGGCTTTCCTGGTCATGCTGCTGATCCAGTTCAGTACCATGGTGGTTGACCGCGCCCTCTACCTGCGCA
AGACCGTGCTGGGCAAGCTGGCCTTCCAGGTGGCGCTGGTGCTGGCCATCCACCTATGGATGTTCTTCATCCTGCCCGCCGTCACTGAGA
GGATGTTCAACCAGAATGTGGTGGCCCAGCTCTGGTACTTCGTGAAGTGCATCTACTTCGCCCTGTCCGCCTACCAGATCCGCTGCGGCT
ACCCCACCCGCATCCTCGGCAACTTCCTCACCAAGAAGTACAATCATCTCAACCTCTTCCTCTTCCAGGGGTTCCGGCTGGTGCCGTTCC
TGGTGGAGCTGCGGGCAGTGATGGACTGGGTGTGGACGGACACCACGCTGTCCCTGTCCAGCTGGATGTGTGTGGAGGACATCTATGCCA
ACATCTTCATCATCAAATGCAGCCGAGAGACAGAGAAGAAATACCCGCAGCCCAAAGGGCAGAAGAAGAAGAAGATCGTCAAGTACGGCA
TGGGTGGCCTCATCATCCTCTTCCTCATCGCCATCATCTGGTTCCCACTGCTCTTCATGTCGCTGGTGCGCTCCGTGGTTGGGGTTGTCA
ACCAGCCCATCGATGTCACCGTCACCCTGAAGCTGGGCGGCTATGAGCCGCTGTTCACCATGAGCGCCCAGCAGCCGTCCATCATCCCCT
TCACGGCCCAGGCCTATGAGGAGCTGTCCCGGCAGTTTGACCCCCAGCCGCTGGCCATGCAGTTCATCAGCCAGTACAGCCCTGAGGACA
TCGTCACGGCGCAGATTGAGGGCAGCTCCGGGGCGCTGTGGCGCATCAGTCCCCCCAGCCGTGCCCAGATGAAGCGGGAGCTCTACAACG
GCACGGCCGACATCACCCTGCGCTTCACCTGGAACTTCCAGAGGGACCTGGCGAAGGGAGGCACTGTGGAGTATGCCAACGAGAAGCACA
TGCTGGCCCTGGCCCCCAACAGCACTGCACGGCGGCAGCTGGCCAGCCTGCTCGAGGGCACCTCGGACCAGTCTGTGGTCATCCCTAATC
TCTTCCCCAAGTACATCCGTGCCCCCAACGGGCCCGAAGCCAACCCTGTGAAGCAGCTGCAGCCCAATGAGGAGGCCGACTACCTCGGCG
TGCGTATCCAGCTGCGGAGGGAGCAGGGTGCGGGGGCCACCGGCTTCCTCGAATGGTGGGTCATCGAGCTGCAGGAGTGCCGGACCGACT
GCAACCTGCTGCCCATGGTCATTTTCAGTGACAAGGTCAGCCCACCGAGCCTCGGCTTCCTGGCTGGCTACGGCATCATGGGGCTGTACG
TGTCCATCGTGCTGGTCATCGGCAAGTTCGTGCGCGGATTCTTCAGCGAGATCTCGCACTCCATTATGTTCGAGGAGCTGCCGTGCGTGG
ACCGCATCCTCAAGCTCTGCCAGGACATCTTCCTGGTGCGGGAGACTCGGGAGCTGGAGCTGGAGGAGGAGTTGTACGCCAAGCTCATCT
TCCTCTACCGCTCACCGGAGACCATGATCAAGTGGACTCGTGAGAAGGAGTAGGAGCTGCTGCTGGCGCCCGAGAGGGAAGGAGCCGGCC
TGCTGGGCAGCGTGGCCACAAGGGGCGGCACTCCTCAGGCCGGGGGAGCCACTGCCCCGTCCAAGGCCGCCAGCTGTGATGCATCCTCCC
GGCCTGCCTGAGCCCTGATGCTGCTGTCAGAGAAGGACACTGCGTCCCCACGGCCTGCGTGGCGCTGCCGTCCCCCACGTGTACTGTAGA

>3004_3004_1_AGRN-PIEZO1_AGRN_chr1_970704_ENST00000379370_PIEZO1_chr16_88815887_ENST00000301015_length(amino acids)=2670AA_BP=168
MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGN
KVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACLLRFSGLS
LVYLLFLLLLPWFPGPTRCGLQGHTGRLLRALLGLSLLFLVAHLALQICLHIVPRLDQLLGPSCSRWETLSRHIGVTRLDLKDIPNAIRL
VAPDLGILVVSSVCLGICGRLARNTRQSPHPRELDDDERDVDASPTAGLQEAATLAPTRRSRLAARFRVTAHWLLVAAGRVLAVTLLALA
GIAHPSALSSVYLLLFLALCTWWACHFPISTRGFSRLCVAVGCFGAGHLICLYCYQMPLAQALLPPAGIWARVLGLKDFVGPTNCSSPHA
LVLNTGLDWPVYASPGVLLLLCYATASLRKLRAYRPSGQRKEAAKGYEARELELAELDQWPQERESDQHVVPTAPDTEADNCIVHELTGQ
SSVLRRPVRPKRAEPREASPLHSLGHLIMDQSYVCALIAMMVWSITYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLYGMTLCCLR
YVWAMDLRPELPTTLGPVSLRQLGLEHTRYPCLDLGAMLLYTLTFWLLLRQFVKEKLLKWAESPAALTEVTVADTEPTRTQTLLQSLGEL
VKGVYAKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYYSLWRKLLKAFWWLVVAYTMLVLIAVYTFQFQDFPAYWRNLTG
FTDEQLGDLGLEQFSVSELFSSILVPGFFLLACILQLHYFHRPFMQLTDMEHVSLPGTRLPRWAHRQDAVSGTPLLREEQQEHQQQQQEE
EEEEEDSRDEGLGVATPHQATQVPEGAAKWGLVAERLLELAAGFSDVLSRVQVFLRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLW
AFALPYPRFRPMASCLSTVWTCVIIVCKMLYQLKVVNPQEYSSNCTEPFPNSTNLLPTEISQSLLYRGPVDPANWFGVRKGFPNLGYIQN
HLQVLLLLVFEAIVYRRQEHYRRQHQLAPLPAQAVFASGTRQQLDQDLLGCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFLVTLHGCW
LVAILTRRHRQAIARLWPNYCLFLALFLLYQYLLCLGMPPALCIDYPWRWSRAVPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQ
QWQVFSAERTEEWQRMAGVNTDRLEPLRGEPNPVPNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGT
ALLQRDTRARLVLWDCLILYNVTVIISKNMLSLLACVFVEQMQTGFCWVIQLFSLVCTVKGYYDPKEMMDRDQDCLLPVEEAGIIWDSVC
FFFLLLQRRVFLSHYYLHVRADLQATALLASRGFALYNAANLKSIDFHRRIEEKSLAQLKRQMERIRAKQEKHRQGRVDRSRPQDTLGPK
DPGLEPGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLFESDSEEEEEAVPEDPRPSAQSAFQLAYQAWVTNAQAVLRRRQQEQEQARQ
EQAGQLPTGGGPSQEVEPAEGPEEAAAGRSHVVQRVLSTAQFLWMLGQALVDELTRWLQEFTRHHGTMSDVLRAERYLLTQELLQGGEVH
RGVLDQLYTSQAEATLPGPTEAPNAPSTVSSGLGAEEPLSSMTDDMGSPLSTGYHTRSGSEEAVTDPGEREAGASLYQGLMRTASELLLD
RRLRIPELEEAELFAEGQGRALRLLRAVYQCVAAHSELLCYFIIILNHMVTASAGSLVLPVLVFLWAMLSIPRPSKRFWMTAIVFTEIAV
VVKYLFQFGFFPWNSHVVLRRYENKPYFPPRILGLEKTDGYIKYDLVQLMALFFHRSQLLCYGLWDHEEDSPSKEHDKSGEEEQGAEEGP
GVPAATTEDHIQVEARVGPTDGTPEPQVELRPRDTRRISLRFRRRKKEGPARKGAAAIEAEDREEEEGEEEKEAPTGREKRPSRSGGRVR
AAGRRLQGFCLSLAQGTYRPLRRFFHDILHTKYRAATDVYALMFLADVVDFIIIIFGFWAFGKHSAATDITSSLSDDQVPEAFLVMLLIQ
FSTMVVDRALYLRKTVLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHL
NLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSSWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPL
LFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRIS
PPSRAQMKRELYNGTADITLRFTWNFQRDLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSDQSVVIPNLFPKYIRAPNGPEANPV
KQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVIELQECRTDCNLLPMVIFSDKVSPPSLGFLAGYGIMGLYVSIVLVIGKFVRGFFSE

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Fusion Gene PPI Analysis for AGRN-PIEZO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AGRN-PIEZO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AGRN-PIEZO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGRNC3808739MYASTHENIC SYNDROME, CONGENITAL, 83GENOMICS_ENGLAND;UNIPROT
HgeneAGRNC0751883Congenital Myasthenic Syndromes, Postsynaptic2CTD_human;ORPHANET
HgeneAGRNC0751884Congenital Myasthenic Syndromes, Presynaptic2CTD_human;ORPHANET
HgeneAGRNC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneAGRNC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneAGRNC0751882Myasthenic Syndromes, Congenital1CTD_human;GENOMICS_ENGLAND
HgeneAGRNC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneC4551512DEHYDRATED HEREDITARY STOMATOCYTOSIS 1 WITH OR WITHOUT PSEUDOHYPERKALEMIA AND/OR PERINATAL EDEMA7GENOMICS_ENGLAND;UNIPROT
TgeneC4225184LYMPHATIC MALFORMATION 64CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0272051Xerocytosis3GENOMICS_ENGLAND;ORPHANET
TgeneC0272048stomatocytic anemia2GENOMICS_ENGLAND
TgeneC0677598Stomatocytosis Result2GENOMICS_ENGLAND