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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KCNMA1-MSMB (FusionGDB2 ID:HG3778TG4477) |
Fusion Gene Summary for KCNMA1-MSMB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCNMA1-MSMB | Fusion gene ID: hg3778tg4477 | Hgene | Tgene | Gene symbol | KCNMA1 | MSMB | Gene ID | 3778 | 4477 |
| Gene name | potassium calcium-activated channel subfamily M alpha 1 | microseminoprotein beta | |
| Synonyms | BKTM|CADEDS|IEG16|KCa1.1|LIWAS|MaxiK|PNKD3|SAKCA|SLO|SLO-ALPHA|SLO1|bA205K10.1|hSlo|mSLO1 | HPC13|IGBF|MSP|MSPB|PN44|PRPS|PSP|PSP-94|PSP57|PSP94 | |
| Cytomap | ('KCNMA1')('MSMB') 10q22.3 | 10q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium-activated potassium channel subunit alpha-1uncharacterized proteinBK channel alpha subunitBKCA alpha subunitbig potassium channel alpha subunitcalcium-activated potassium channel, subfamily M subunit alpha-1k(VCA)alphamaxi-K channel HSLOpo | beta-microseminoproteinimmunoglobulin binding factorprostate secreted seminal plasma proteinprostate secretory protein of 94 amino acidsseminal plasma beta-inhibin | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000286627, ENST00000286628, ENST00000354353, ENST00000372440, ENST00000372443, ENST00000404771, ENST00000404857, ENST00000406533, ENST00000480683, ENST00000481070, ENST00000484507, | ||
| Fusion gene scores | * DoF score | 20 X 17 X 10=3400 | 18 X 7 X 6=756 |
| # samples | 25 | 21 | |
| ** MAII score | log2(25/3400*10)=-3.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(21/756*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KCNMA1 [Title/Abstract] AND MSMB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KCNMA1(78869931)-MSMB(51555731), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | KCNMA1-MSMB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCNMA1-MSMB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCNMA1-MSMB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KCNMA1-MSMB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KCNMA1 | GO:0001666 | response to hypoxia | 15528406 |
| Hgene | KCNMA1 | GO:0006813 | potassium ion transport | 7573516|7877450|11245614|12388065|17706472|18458941 |
| Hgene | KCNMA1 | GO:0006970 | response to osmotic stress | 10840032|12388065 |
| Hgene | KCNMA1 | GO:0030007 | cellular potassium ion homeostasis | 11245614 |
| Hgene | KCNMA1 | GO:0034465 | response to carbon monoxide | 15528406 |
| Hgene | KCNMA1 | GO:0042391 | regulation of membrane potential | 7877450|7993625 |
| Hgene | KCNMA1 | GO:0045794 | negative regulation of cell volume | 12388065 |
| Hgene | KCNMA1 | GO:0051592 | response to calcium ion | 12388065|18458941 |
| Hgene | KCNMA1 | GO:0060073 | micturition | 11641143 |
| Hgene | KCNMA1 | GO:0060083 | smooth muscle contraction involved in micturition | 11641143 |
| Fusion gene breakpoints across KCNMA1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MSMB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A2-A25D-01A | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| ChimerDB4 | BRCA | TCGA-A2-A25D-01A | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | + |
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Fusion Gene ORF analysis for KCNMA1-MSMB |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000286627 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000286627 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000286628 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000286628 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000354353 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000354353 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000372440 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000372440 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000372443 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000372443 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000404771 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000404771 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000404857 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000404857 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000406533 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| 5CDS-3UTR | ENST00000406533 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| In-frame | ENST00000286627 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| In-frame | ENST00000286628 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| In-frame | ENST00000354353 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| In-frame | ENST00000372440 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| In-frame | ENST00000372443 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| In-frame | ENST00000404771 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| In-frame | ENST00000404857 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| In-frame | ENST00000406533 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| intron-3CDS | ENST00000480683 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| intron-3CDS | ENST00000481070 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| intron-3CDS | ENST00000484507 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| intron-3UTR | ENST00000480683 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| intron-3UTR | ENST00000480683 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| intron-3UTR | ENST00000481070 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| intron-3UTR | ENST00000481070 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| intron-3UTR | ENST00000484507 | ENST00000298239 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| intron-3UTR | ENST00000484507 | ENST00000474170 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000404771 | KCNMA1 | chr10 | 78869931 | - | ENST00000358559 | MSMB | chr10 | 51555731 | - | 1706 | 1247 | 62 | 1588 | 508 |
| ENST00000372440 | KCNMA1 | chr10 | 78869931 | - | ENST00000358559 | MSMB | chr10 | 51555731 | - | 1941 | 1482 | 297 | 1823 | 508 |
| ENST00000372443 | KCNMA1 | chr10 | 78869931 | - | ENST00000358559 | MSMB | chr10 | 51555731 | - | 2317 | 1858 | 673 | 2199 | 508 |
| ENST00000286628 | KCNMA1 | chr10 | 78869931 | - | ENST00000358559 | MSMB | chr10 | 51555731 | - | 1590 | 1131 | 0 | 1472 | 490 |
| ENST00000286627 | KCNMA1 | chr10 | 78869931 | - | ENST00000358559 | MSMB | chr10 | 51555731 | - | 2543 | 2084 | 899 | 2425 | 508 |
| ENST00000354353 | KCNMA1 | chr10 | 78869931 | - | ENST00000358559 | MSMB | chr10 | 51555731 | - | 1590 | 1131 | 0 | 1472 | 490 |
| ENST00000404857 | KCNMA1 | chr10 | 78869931 | - | ENST00000358559 | MSMB | chr10 | 51555731 | - | 1590 | 1131 | 0 | 1472 | 490 |
| ENST00000406533 | KCNMA1 | chr10 | 78869931 | - | ENST00000358559 | MSMB | chr10 | 51555731 | - | 1590 | 1131 | 0 | 1472 | 490 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000404771 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - | 0.002884477 | 0.9971155 |
| ENST00000372440 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - | 0.003571844 | 0.9964282 |
| ENST00000372443 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - | 0.005180155 | 0.9948198 |
| ENST00000286628 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - | 0.002178571 | 0.99782145 |
| ENST00000286627 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - | 0.005726124 | 0.99427384 |
| ENST00000354353 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - | 0.002178571 | 0.99782145 |
| ENST00000404857 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - | 0.002178571 | 0.99782145 |
| ENST00000406533 | ENST00000358559 | KCNMA1 | chr10 | 78869931 | - | MSMB | chr10 | 51555731 | - | 0.002178571 | 0.99782145 |
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Fusion Genomic Features for KCNMA1-MSMB |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| KCNMA1 | chr10 | 78869930 | - | MSMB | chr10 | 51555730 | - | 0.021667548 | 0.97833246 |
| KCNMA1 | chr10 | 78869930 | - | MSMB | chr10 | 51555730 | + | 0.021667548 | 0.97833246 |
| KCNMA1 | chr10 | 78869930 | - | MSMB | chr10 | 51555730 | - | 0.021667548 | 0.97833246 |
| KCNMA1 | chr10 | 78869930 | - | MSMB | chr10 | 51555730 | + | 0.021667548 | 0.97833246 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KCNMA1-MSMB |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:78869931/chr10:51555731) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 13_20 | 377 | 1179.0 | Compositional bias | Note=Poly-Gly |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 39_60 | 377 | 1179.0 | Compositional bias | Note=Poly-Ser |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 4_10 | 377 | 1179.0 | Compositional bias | Note=Poly-Gly |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 13_20 | 377 | 1237.0 | Compositional bias | Note=Poly-Gly |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 39_60 | 377 | 1237.0 | Compositional bias | Note=Poly-Ser |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 4_10 | 377 | 1237.0 | Compositional bias | Note=Poly-Gly |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 13_20 | 377 | 1220.0 | Compositional bias | Note=Poly-Gly |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 39_60 | 377 | 1220.0 | Compositional bias | Note=Poly-Ser |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 4_10 | 377 | 1220.0 | Compositional bias | Note=Poly-Gly |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 336_358 | 377 | 1179.0 | Intramembrane | Pore-forming%3B Name%3DP region |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 336_358 | 377 | 1237.0 | Intramembrane | Pore-forming%3B Name%3DP region |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 336_358 | 377 | 1220.0 | Intramembrane | Pore-forming%3B Name%3DP region |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 352_355 | 377 | 1179.0 | Motif | Note=Selectivity for potassium |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 352_355 | 377 | 1237.0 | Motif | Note=Selectivity for potassium |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 352_355 | 377 | 1220.0 | Motif | Note=Selectivity for potassium |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 108_178 | 377 | 1179.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 1_86 | 377 | 1179.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 200_214 | 377 | 1179.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 236_239 | 377 | 1179.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 261_264 | 377 | 1179.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 286_300 | 377 | 1179.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 322_335 | 377 | 1179.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 359_367 | 377 | 1179.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 108_178 | 377 | 1237.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 1_86 | 377 | 1237.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 200_214 | 377 | 1237.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 236_239 | 377 | 1237.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 261_264 | 377 | 1237.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 286_300 | 377 | 1237.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 322_335 | 377 | 1237.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 359_367 | 377 | 1237.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 108_178 | 377 | 1220.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 1_86 | 377 | 1220.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 200_214 | 377 | 1220.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 236_239 | 377 | 1220.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 261_264 | 377 | 1220.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 286_300 | 377 | 1220.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 322_335 | 377 | 1220.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 359_367 | 377 | 1220.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 179_199 | 377 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S1 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 215_235 | 377 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S2 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 240_260 | 377 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S3 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 265_285 | 377 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S4 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 301_321 | 377 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 87_107 | 377 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S0 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 179_199 | 377 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S1 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 215_235 | 377 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S2 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 240_260 | 377 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S3 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 265_285 | 377 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S4 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 301_321 | 377 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 87_107 | 377 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S0 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 179_199 | 377 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S1 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 215_235 | 377 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S2 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 240_260 | 377 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S3 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 265_285 | 377 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S4 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 301_321 | 377 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 87_107 | 377 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S0 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 13_20 | 0 | 169.0 | Compositional bias | Note=Poly-Gly |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 39_60 | 0 | 169.0 | Compositional bias | Note=Poly-Ser |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 4_10 | 0 | 169.0 | Compositional bias | Note=Poly-Gly |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 415_558 | 377 | 1179.0 | Domain | Note=RCK N-terminal |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 415_558 | 377 | 1237.0 | Domain | Note=RCK N-terminal |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 415_558 | 377 | 1220.0 | Domain | Note=RCK N-terminal |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 415_558 | 0 | 169.0 | Domain | Note=RCK N-terminal |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 336_358 | 0 | 169.0 | Intramembrane | Pore-forming%3B Name%3DP region |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 1003_1025 | 377 | 1179.0 | Motif | Note=Calcium bowl |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 1003_1025 | 377 | 1237.0 | Motif | Note=Calcium bowl |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 1003_1025 | 377 | 1220.0 | Motif | Note=Calcium bowl |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 1003_1025 | 0 | 169.0 | Motif | Note=Calcium bowl |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 352_355 | 0 | 169.0 | Motif | Note=Selectivity for potassium |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 1032_1052 | 377 | 1179.0 | Region | Note=Segment S10 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 556_576 | 377 | 1179.0 | Region | Note=Segment S7 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 613_633 | 377 | 1179.0 | Region | Note=Segment S8 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 677_681 | 377 | 1179.0 | Region | Note=Heme-binding motif |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 837_857 | 377 | 1179.0 | Region | Note=Segment S9 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 1032_1052 | 377 | 1237.0 | Region | Note=Segment S10 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 556_576 | 377 | 1237.0 | Region | Note=Segment S7 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 613_633 | 377 | 1237.0 | Region | Note=Segment S8 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 677_681 | 377 | 1237.0 | Region | Note=Heme-binding motif |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 837_857 | 377 | 1237.0 | Region | Note=Segment S9 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 1032_1052 | 377 | 1220.0 | Region | Note=Segment S10 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 556_576 | 377 | 1220.0 | Region | Note=Segment S7 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 613_633 | 377 | 1220.0 | Region | Note=Segment S8 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 677_681 | 377 | 1220.0 | Region | Note=Heme-binding motif |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 837_857 | 377 | 1220.0 | Region | Note=Segment S9 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 1032_1052 | 0 | 169.0 | Region | Note=Segment S10 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 556_576 | 0 | 169.0 | Region | Note=Segment S7 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 613_633 | 0 | 169.0 | Region | Note=Segment S8 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 677_681 | 0 | 169.0 | Region | Note=Heme-binding motif |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 837_857 | 0 | 169.0 | Region | Note=Segment S9 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 389_1236 | 377 | 1179.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 389_1236 | 377 | 1237.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 389_1236 | 377 | 1220.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 108_178 | 0 | 169.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 1_86 | 0 | 169.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 200_214 | 0 | 169.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 236_239 | 0 | 169.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 261_264 | 0 | 169.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 286_300 | 0 | 169.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 322_335 | 0 | 169.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 359_367 | 0 | 169.0 | Topological domain | Extracellular |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 389_1236 | 0 | 169.0 | Topological domain | Cytoplasmic |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286627 | - | 8 | 27 | 368_388 | 377 | 1179.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000286628 | - | 8 | 28 | 368_388 | 377 | 1237.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000404857 | - | 8 | 28 | 368_388 | 377 | 1220.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 179_199 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S1 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 215_235 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S2 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 240_260 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S3 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 265_285 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S4 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 301_321 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S5 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 368_388 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S6 |
| Hgene | KCNMA1 | chr10:78869931 | chr10:51555731 | ENST00000480683 | - | 1 | 2 | 87_107 | 0 | 169.0 | Transmembrane | Helical%3B Name%3DSegment S0 |
Top |
Fusion Gene Sequence for KCNMA1-MSMB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >41495_41495_1_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000286627_MSMB_chr10_51555731_ENST00000358559_length(transcript)=2543nt_BP=2084nt CCGGGCCGCTGCCGAGGGGCCCTGCCCACCCCTGCCCAGCCCGGAGCCCAGGCGAGCCAGCGCGGCGAGCCTCCTCCCCTCCCGCCTGGG TCGTCCTGAGTCCGCGCCCGCTCCAGTTGCTGCAGCTGCTGCTGCTGGCGGCTGCGGGGAGCGCGGGGCGCGCGCCGAAGAGGCTTGGGC GGCGAGGACGGGGACGAGGAGGAGTCGGAGGCGGCAAGGAGGAAGAGCGAGCGGAGGCCGAGGGGCTCAGCGGCGTGGCGACAGGACTAG GGGGTCCCGAGAACATGGGCTAGCAGGCGGCCACGGGCCGGCGGCCGGACGCGGTGAACCTGCCGCGGCCGGGCGCGCACTGGCGCGGCG AGCCGGAGCCGAGCGCAGCCGGGGGAGGAGGGCTGGCGCAGGGGCGCCCGGGCGGAGGGGGCCGATTATCCATTATTAACGAGTTACCAC CTAATAAGCGGAGAGCGGCTCGTTAGCCGCGCGGGAGGCGCTCGGGGAAGGGGGTCACCGGCCGAGCGCAGCGCACACCCGTGGCGCACG GCGGGCGGCGCGGCGCCGAGGACACCCGGGACCGCGCGCGGAGCCGGGGCGGGCCCGGGGGCGGCGCAGACCCCGGGCGCGGGCGGCCCG CGGCGCCCCCTGGCTCTCGGCGCTCGGGGCCAGCGCAGCCCGGGGCGAGCGGGGCGCGGGCCGGGGAGGGGGAGCTGCCCGCGCACTCCA TCCCCCTCCCCCCCGGGCGGGCGGCGGCGGCTCGCTGTATATATCTCGGCGCACCCCGCCAGGTCGCGCACAGCGCCCCGAGCCCAGGCG CCTCCCCGCCCCCCTCCCGCGCTCCGCGGCGGCGGCGGCGGCGGCAGCAGTAGCAGCAATATGGCTGTTGATGGGTGTTTGGGGTGGCGC TGGCGGCGGGAGGAGCTCCCCCGAGCCCCTGCGCCGGCTGCCCGTTGCTAGCTATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCG GCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCT CCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGG TGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCT TCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCACTGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACA ATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGA AGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTG TAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTACAAAGATTTCACATTACAGATCGACATGGCTTTCAACG TGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTGTGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCT TCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTT CAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTGGTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGA CTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAATTTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTG TCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCAAAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCA TCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTCGTGACTTTATGCAATGCATCATGCTATTTCATACCTA ATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAACAAACACCCAATAAACTCGGAGTGGCAGACTGACAACT GTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCTACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAA TCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAAAAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTG CTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTAATAGTCAATGATTGTGTAGCCATGCCTATCAGTAAAA >41495_41495_1_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000286627_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395 MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN -------------------------------------------------------------- >41495_41495_2_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000286628_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1590nt_BP=1131nt ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTG GTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAAT TTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCA AAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTC GTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAAC AAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCT ACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAA AAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTA >41495_41495_2_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000286628_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS -------------------------------------------------------------- >41495_41495_3_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000354353_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1590nt_BP=1131nt ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTG GTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAAT TTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCA AAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTC GTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAAC AAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCT ACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAA AAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTA >41495_41495_3_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000354353_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS -------------------------------------------------------------- >41495_41495_4_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000372440_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1941nt_BP=1482nt GGCGCAGACCCCGGGCGCGGGCGGCCCGCGGCGCCCCCTGGCTCTCGGCGCTCGGGGCCAGCGCAGCCCGGGGCGAGCGGGGCGCGGGCC GGGGAGGGGGAGCTGCCCGCGCACTCCATCCCCCTCCCCCCCGGGCGGGCGGCGGCGGCTCGCTGTATATATCTCGGCGCACCCCGCCAG GTCGCGCACAGCGCCCCGAGCCCAGGCGCCTCCCCGCCCCCCTCCCGCGCTCCGCGGCGGCGGCGGCGGCGGCAGCAGTAGCAGCAATAT GGCTGTTGATGGGTGTTTGGGGTGGCGCTGGCGGCGGGAGGAGCTCCCCCGAGCCCCTGCGCCGGCTGCCCGTTGCTAGCTATGGCAAAT GGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCACGCGAACCAT CTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCGGTCCACGAG CCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTCCTGGCCTCC TCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCACTGCGGGGGC AAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAGGCAGTGGCC GCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTGGTTGTCTTA GTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTACAAAGATTTC ACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTGTGGTTCTGG CTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGTTTGAGATTT TTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTGGTGAATCTG CTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAATTTCCAAAAC AACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCAAAAACCACA CTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTCGTGACTTTA TGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAACAAACACCCA ATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCTACACCTGTG GGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAAAAGACCTGT TCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTAATAGTCAAT >41495_41495_4_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000372440_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395 MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN -------------------------------------------------------------- >41495_41495_5_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000372443_MSMB_chr10_51555731_ENST00000358559_length(transcript)=2317nt_BP=1858nt GCGAGCGGAGGCCGAGGGGCTCAGCGGCGTGGCGACAGGACTAGGGGGTCCCGAGAACATGGGCTAGCAGGCGGCCACGGGCCGGCGGCC GGACGCGGTGAACCTGCCGCGGCCGGGCGCGCACTGGCGCGGCGAGCCGGAGCCGAGCGCAGCCGGGGGAGGAGGGCTGGCGCAGGGGCG CCCGGGCGGAGGGGGCCGATTATCCATTATTAACGAGTTACCACCTAATAAGCGGAGAGCGGCTCGTTAGCCGCGCGGGAGGCGCTCGGG GAAGGGGGTCACCGGCCGAGCGCAGCGCACACCCGTGGCGCACGGCGGGCGGCGCGGCGCCGAGGACACCCGGGACCGCGCGCGGAGCCG GGGCGGGCCCGGGGGCGGCGCAGACCCCGGGCGCGGGCGGCCCGCGGCGCCCCCTGGCTCTCGGCGCTCGGGGCCAGCGCAGCCCGGGGC GAGCGGGGCGCGGGCCGGGGAGGGGGAGCTGCCCGCGCACTCCATCCCCCTCCCCCCCGGGCGGGCGGCGGCGGCTCGCTGTATATATCT CGGCGCACCCCGCCAGGTCGCGCACAGCGCCCCGAGCCCAGGCGCCTCCCCGCCCCCCTCCCGCGCTCCGCGGCGGCGGCGGCGGCGGCA GCAGTAGCAGCAATATGGCTGTTGATGGGTGTTTGGGGTGGCGCTGGCGGCGGGAGGAGCTCCCCCGAGCCCCTGCGCCGGCTGCCCGTT GCTAGCTATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAA TATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTC GTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTG GGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTG CTGCCACTGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAA AGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAG AGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAA TTTCTACAAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGA TAAATTGTGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTG GCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCAT CAAGCTGGTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATG GGAAAATTTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGT TTATGCAAAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGC CACCTTCGTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAA AGGAAACAAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCT TGTTTCTACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGA CCCAAAAAAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTG >41495_41495_5_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000372443_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395 MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN -------------------------------------------------------------- >41495_41495_6_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000404771_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1706nt_BP=1247nt GGCGGCGGCGGCGGCGGCAGCAGTAGCAGCAATATGGCTGTTGATGGGTGTTTGGGGTGGCGCTGGCGGCGGGAGGAGCTCCCCCGAGCC CCTGCGCCGGCTGCCCGTTGCTAGCTATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCA GTCTTAGAATGAGTAGCAATATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTT CCTCCTCCTCTTCCTCCTCGTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCC GGGGCCAACGCATGTGGTGGGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCA AGTACCTGTGGACCGTGTGCTGCCACTGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTC TCAAACCAGTGGATGAAAAAGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCG CCCAGACACTGACTGGCAGAGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACC CAATAGAATCCTGCCAGAATTTCTACAAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGC GGTTTATTGCAGCCAACGATAAATTGTGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTG TGTACTTAAACAGAAGTTGGCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTC TTAAAACAAGTAATTCCATCAAGCTGGTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGG AGAATTCAGGGGACCCATGGGAAAATTTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCA CCGTTGGTTATGGGGATGTTTATGCAAAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGG GCAGCGTTGTGATCTTTGCCACCTTCGTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCA GGAAATGCATGGATCTCAAAGGAAACAAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAG AAATTTCATGTTGCACCCTTGTTTCTACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATA TCGTGGTGGAGAAGAAGGACCCAAAAAAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGC >41495_41495_6_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000404771_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395 MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN -------------------------------------------------------------- >41495_41495_7_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000404857_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1590nt_BP=1131nt ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTG GTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAAT TTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCA AAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTC GTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAAC AAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCT ACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAA AAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTA >41495_41495_7_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000404857_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS -------------------------------------------------------------- >41495_41495_8_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000406533_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1590nt_BP=1131nt ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTG GTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAAT TTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCA AAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTC GTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAAC AAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCT ACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAA AAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTA >41495_41495_8_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000406533_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KCNMA1-MSMB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KCNMA1-MSMB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KCNMA1-MSMB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KCNMA1 | C1836173 | Generalized Epilepsy and Paroxysmal Dyskinesia | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | KCNMA1 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | KCNMA1 | C0005944 | Metabolic Bone Disorder | 1 | CTD_human |
| Hgene | KCNMA1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | KCNMA1 | C0018273 | Growth Disorders | 1 | CTD_human |
| Hgene | KCNMA1 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| Hgene | KCNMA1 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
| Hgene | KCNMA1 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | KCNMA1 | C0028756 | Obesity, Morbid | 1 | CTD_human |
| Hgene | KCNMA1 | C0029453 | Osteopenia | 1 | CTD_human |
| Hgene | KCNMA1 | C0038220 | Status Epilepticus | 1 | CTD_human |
| Hgene | KCNMA1 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | KCNMA1 | C0270823 | Petit mal status | 1 | CTD_human |
| Hgene | KCNMA1 | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | KCNMA1 | C0311335 | Grand Mal Status Epilepticus | 1 | CTD_human |
| Hgene | KCNMA1 | C0393734 | Complex Partial Status Epilepticus | 1 | CTD_human |
| Hgene | KCNMA1 | C0410916 | Neonatal Death | 1 | CTD_human |
| Hgene | KCNMA1 | C0701826 | Perinatal death | 1 | CTD_human |
| Hgene | KCNMA1 | C0751522 | Status Epilepticus, Subclinical | 1 | CTD_human |
| Hgene | KCNMA1 | C0751523 | Non-Convulsive Status Epilepticus | 1 | CTD_human |
| Hgene | KCNMA1 | C0751524 | Simple Partial Status Epilepticus | 1 | CTD_human |
| Hgene | KCNMA1 | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | KCNMA1 | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | KCNMA1 | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human |
| Hgene | KCNMA1 | C1306837 | Papillary Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | KCNMA1 | C4539985 | CEREBELLAR ATROPHY, DEVELOPMENTAL DELAY, AND SEIZURES | 1 | GENOMICS_ENGLAND |
| Tgene | C0033578 | Prostatic Neoplasms | 3 | CTD_human | |
| Tgene | C0376358 | Malignant neoplasm of prostate | 3 | CTD_human | |
| Tgene | C2931456 | Prostate cancer, familial | 3 | ORPHANET |
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