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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IPO5-IPO5 (FusionGDB2 ID:HG3843TG3843)

Fusion Gene Summary for IPO5-IPO5

check button Fusion gene summary
Fusion gene informationFusion gene name: IPO5-IPO5
Fusion gene ID: hg3843tg3843
HgeneTgene
Gene symbol

IPO5

IPO5

Gene ID

3843

3843

Gene nameimportin 5importin 5
SynonymsIMB3|KPNB3|Pse1|RANBP5|imp5IMB3|KPNB3|Pse1|RANBP5|imp5
Cytomap('IPO5')('IPO5')

13q32.2

13q32.2

Type of geneprotein-codingprotein-coding
Descriptionimportin-5RAN binding protein 5Ran_GTP binding protein 5importin beta-3 subunitimportin subunit beta-3karyopherin (importin) beta 3karyopherin beta-3ran-binding protein 5importin-5RAN binding protein 5Ran_GTP binding protein 5importin beta-3 subunitimportin subunit beta-3karyopherin (importin) beta 3karyopherin beta-3ran-binding protein 5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000493492, ENST00000261574, 
ENST00000490680, ENST00000539640, 
ENST00000261574, ENST00000490680, 
ENST00000539640, ENST00000493492, 
Fusion gene scores* DoF score3 X 6 X 1=1810 X 13 X 4=520
# samples 613
** MAII scorelog2(6/18*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(13/520*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IPO5 [Title/Abstract] AND IPO5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIPO5(98628910)-IPO5(98666336), # samples:2
Anticipated loss of major functional domain due to fusion event.IPO5-IPO5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IPO5-IPO5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IPO5-IPO5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
IPO5-IPO5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIPO5

GO:0006610

ribosomal protein import into nucleus

9687515

TgeneIPO5

GO:0006610

ribosomal protein import into nucleus

9687515


check buttonFusion gene breakpoints across IPO5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across IPO5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for IPO5-IPO5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IPO5-IPO5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for IPO5-IPO5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:98628910/chr13:98666336)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+17292_65901116.0Compositional biasNote=Poly-Ala
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729460_4655901116.0Compositional biasNote=Poly-Ala
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+14262_65721098.0Compositional biasNote=Poly-Ala
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426460_4655721098.0Compositional biasNote=Poly-Ala
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+172928_995901116.0DomainImportin N-terminal
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+142628_995721098.0DomainImportin N-terminal
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729325_3755901116.0RegionRan-GTP binding
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426325_3755721098.0RegionRan-GTP binding
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729130_1575901116.0RepeatHEAT 4
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729167_2015901116.0RepeatHEAT 5
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729210_2465901116.0RepeatHEAT 6
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729254_2895901116.0RepeatHEAT 7
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729298_3505901116.0RepeatHEAT 8
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729352_3865901116.0RepeatHEAT 9
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729390_4305901116.0RepeatHEAT 10
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729432_4725901116.0RepeatHEAT 11
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+172943_775901116.0RepeatHEAT 2
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729475_5235901116.0RepeatHEAT 12
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729525_5685901116.0RepeatHEAT 13
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+17295_385901116.0RepeatHEAT 1
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+172995_1225901116.0RepeatHEAT 3
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426130_1575721098.0RepeatHEAT 4
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426167_2015721098.0RepeatHEAT 5
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426210_2465721098.0RepeatHEAT 6
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426254_2895721098.0RepeatHEAT 7
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426298_3505721098.0RepeatHEAT 8
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426352_3865721098.0RepeatHEAT 9
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426390_4305721098.0RepeatHEAT 10
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426432_4725721098.0RepeatHEAT 11
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+142643_775721098.0RepeatHEAT 2
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426475_5235721098.0RepeatHEAT 12
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426525_5685721098.0RepeatHEAT 13
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+14265_385721098.0RepeatHEAT 1
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+142695_1225721098.0RepeatHEAT 3
TgeneIPO5chr13:98658596chr13:98658460ENST000002615740292_601116.0Compositional biasNote=Poly-Ala
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029460_46501116.0Compositional biasNote=Poly-Ala
TgeneIPO5chr13:98658596chr13:98658460ENST000004906800262_601098.0Compositional biasNote=Poly-Ala
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026460_46501098.0Compositional biasNote=Poly-Ala
TgeneIPO5chr13:98658596chr13:98658460ENST0000026157402928_9901116.0DomainImportin N-terminal
TgeneIPO5chr13:98658596chr13:98658460ENST0000049068002628_9901098.0DomainImportin N-terminal
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029325_37501116.0RegionRan-GTP binding
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026325_37501098.0RegionRan-GTP binding
TgeneIPO5chr13:98658596chr13:98658460ENST000002615740291032_106701116.0RepeatHEAT 23
TgeneIPO5chr13:98658596chr13:98658460ENST000002615740291070_109301116.0RepeatHEAT 24
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029130_15701116.0RepeatHEAT 4
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029167_20101116.0RepeatHEAT 5
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029210_24601116.0RepeatHEAT 6
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029254_28901116.0RepeatHEAT 7
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029298_35001116.0RepeatHEAT 8
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029352_38601116.0RepeatHEAT 9
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029390_43001116.0RepeatHEAT 10
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029432_47201116.0RepeatHEAT 11
TgeneIPO5chr13:98658596chr13:98658460ENST0000026157402943_7701116.0RepeatHEAT 2
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029475_52301116.0RepeatHEAT 12
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029525_56801116.0RepeatHEAT 13
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029570_61501116.0RepeatHEAT 14
TgeneIPO5chr13:98658596chr13:98658460ENST000002615740295_3801116.0RepeatHEAT 1
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029617_69201116.0RepeatHEAT 15
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029695_73701116.0RepeatHEAT 16
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029741_78001116.0RepeatHEAT 17
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029787_85301116.0RepeatHEAT 18
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029856_89501116.0RepeatHEAT 19
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029903_93501116.0RepeatHEAT 20
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029943_98301116.0RepeatHEAT 21
TgeneIPO5chr13:98658596chr13:98658460ENST0000026157402995_12201116.0RepeatHEAT 3
TgeneIPO5chr13:98658596chr13:98658460ENST00000261574029990_102101116.0RepeatHEAT 22
TgeneIPO5chr13:98658596chr13:98658460ENST000004906800261032_106701098.0RepeatHEAT 23
TgeneIPO5chr13:98658596chr13:98658460ENST000004906800261070_109301098.0RepeatHEAT 24
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026130_15701098.0RepeatHEAT 4
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026167_20101098.0RepeatHEAT 5
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026210_24601098.0RepeatHEAT 6
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026254_28901098.0RepeatHEAT 7
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026298_35001098.0RepeatHEAT 8
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026352_38601098.0RepeatHEAT 9
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026390_43001098.0RepeatHEAT 10
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026432_47201098.0RepeatHEAT 11
TgeneIPO5chr13:98658596chr13:98658460ENST0000049068002643_7701098.0RepeatHEAT 2
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026475_52301098.0RepeatHEAT 12
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026525_56801098.0RepeatHEAT 13
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026570_61501098.0RepeatHEAT 14
TgeneIPO5chr13:98658596chr13:98658460ENST000004906800265_3801098.0RepeatHEAT 1
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026617_69201098.0RepeatHEAT 15
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026695_73701098.0RepeatHEAT 16
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026741_78001098.0RepeatHEAT 17
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026787_85301098.0RepeatHEAT 18
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026856_89501098.0RepeatHEAT 19
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026903_93501098.0RepeatHEAT 20
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026943_98301098.0RepeatHEAT 21
TgeneIPO5chr13:98658596chr13:98658460ENST0000049068002695_12201098.0RepeatHEAT 3
TgeneIPO5chr13:98658596chr13:98658460ENST00000490680026990_102101098.0RepeatHEAT 22

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+17291032_10675901116.0RepeatHEAT 23
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+17291070_10935901116.0RepeatHEAT 24
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729570_6155901116.0RepeatHEAT 14
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729617_6925901116.0RepeatHEAT 15
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729695_7375901116.0RepeatHEAT 16
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729741_7805901116.0RepeatHEAT 17
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729787_8535901116.0RepeatHEAT 18
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729856_8955901116.0RepeatHEAT 19
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729903_9355901116.0RepeatHEAT 20
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729943_9835901116.0RepeatHEAT 21
HgeneIPO5chr13:98658596chr13:98658460ENST00000261574+1729990_10215901116.0RepeatHEAT 22
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+14261032_10675721098.0RepeatHEAT 23
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+14261070_10935721098.0RepeatHEAT 24
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426570_6155721098.0RepeatHEAT 14
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426617_6925721098.0RepeatHEAT 15
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426695_7375721098.0RepeatHEAT 16
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426741_7805721098.0RepeatHEAT 17
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426787_8535721098.0RepeatHEAT 18
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426856_8955721098.0RepeatHEAT 19
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426903_9355721098.0RepeatHEAT 20
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426943_9835721098.0RepeatHEAT 21
HgeneIPO5chr13:98658596chr13:98658460ENST00000490680+1426990_10215721098.0RepeatHEAT 22


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Fusion Gene Sequence for IPO5-IPO5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IPO5-IPO5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IPO5-IPO5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IPO5-IPO5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIPO5C0036341Schizophrenia4PSYGENET
HgeneIPO5C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneC0036341Schizophrenia4PSYGENET
TgeneC0152013Adenocarcinoma of lung (disorder)1CTD_human