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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CEP85L-ROS1 (FusionGDB2 ID:HG387119TG6098) |
Fusion Gene Summary for CEP85L-ROS1 |
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Fusion gene information | Fusion gene name: CEP85L-ROS1 | Fusion gene ID: hg387119tg6098 | Hgene | Tgene | Gene symbol | CEP85L | ROS1 | Gene ID | 387119 | 6098 |
Gene name | centrosomal protein 85 like | ROS proto-oncogene 1, receptor tyrosine kinase | |
Synonyms | C6orf204|NY-BR-15|bA57K17.2 | MCF3|ROS|c-ros-1 | |
Cytomap | ('C6orf204','CEP85L')('ROS1','ROS1') 6q22.31 | 6q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | centrosomal protein of 85 kDa-likecentrosomal protein 85kDa-likeserologically defined breast cancer antigen NY-BR-15 | proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1 | |
Modification date | 20200313 | 20200314 | |
UniProtAcc | . | P08922 | |
Ensembl transtripts involved in fusion gene | ENST00000368488, ENST00000368491, ENST00000360290, ENST00000392500, ENST00000419517, ENST00000472713, | ||
Fusion gene scores | * DoF score | 10 X 10 X 6=600 | 18 X 20 X 5=1800 |
# samples | 11 | 20 | |
** MAII score | log2(11/600*10)=-2.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1800*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CEP85L [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | C6orf204(118802942)-ROS1(117641193), # samples:1 CEP85L(118802942)-ROS1(117641193), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | CEP85L-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEP85L-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEP85L-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CEP85L-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CEP85L-ROS1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CEP85L-ROS1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CEP85L-ROS1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ROS1 | GO:0001558 | regulation of cell growth | 16885344 |
Tgene | ROS1 | GO:0006468 | protein phosphorylation | 16885344 |
Tgene | ROS1 | GO:0032006 | regulation of TOR signaling | 16885344 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | GBM | TCGA-06-5418-01A | C6orf204 | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
ChimerDB4 | GBM | TCGA-06-5418-01A | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
ChimerKB4 | . | . | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
ChimerKB4 | . | . | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
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Fusion Gene ORF analysis for CEP85L-ROS1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000368488 | ENST00000368507 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
Frame-shift | ENST00000368488 | ENST00000368508 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
In-frame | ENST00000368491 | ENST00000368507 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
In-frame | ENST00000368491 | ENST00000368508 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
intron-3CDS | ENST00000360290 | ENST00000368507 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
intron-3CDS | ENST00000360290 | ENST00000368508 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
intron-3CDS | ENST00000392500 | ENST00000368507 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
intron-3CDS | ENST00000392500 | ENST00000368508 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
intron-3CDS | ENST00000419517 | ENST00000368507 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
intron-3CDS | ENST00000419517 | ENST00000368508 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
intron-3CDS | ENST00000472713 | ENST00000368507 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
intron-3CDS | ENST00000472713 | ENST00000368508 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - |
intron-intron | ENST00000360290 | ENST00000368507 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000360290 | ENST00000368507 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000360290 | ENST00000368508 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000360290 | ENST00000368508 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000368488 | ENST00000368507 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000368488 | ENST00000368507 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000368488 | ENST00000368508 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000368488 | ENST00000368508 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000368491 | ENST00000368507 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000368491 | ENST00000368507 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000368491 | ENST00000368508 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000368491 | ENST00000368508 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000392500 | ENST00000368507 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000392500 | ENST00000368507 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000392500 | ENST00000368508 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000392500 | ENST00000368508 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000419517 | ENST00000368507 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000419517 | ENST00000368507 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000419517 | ENST00000368508 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000419517 | ENST00000368508 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000472713 | ENST00000368507 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000472713 | ENST00000368507 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
intron-intron | ENST00000472713 | ENST00000368508 | CEP85L | chr6 | 118791807 | - | ROS1 | chr6 | 118791807 | - |
intron-intron | ENST00000472713 | ENST00000368508 | CEP85L | chr6 | 118805021 | - | ROS1 | chr6 | 118805021 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000368491 | CEP85L | chr6 | 118802942 | - | ENST00000368508 | ROS1 | chr6 | 117641193 | - | 3826 | 2367 | 511 | 3633 | 1040 |
ENST00000368491 | CEP85L | chr6 | 118802942 | - | ENST00000368507 | ROS1 | chr6 | 117641193 | - | 3826 | 2367 | 511 | 3633 | 1040 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000368491 | ENST00000368508 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - | 0.001415956 | 0.99858403 |
ENST00000368491 | ENST00000368507 | CEP85L | chr6 | 118802942 | - | ROS1 | chr6 | 117641193 | - | 0.001415956 | 0.99858403 |
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Fusion Genomic Features for CEP85L-ROS1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CEP85L-ROS1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:118802942/chr6:117641193) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | ROS1 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 1945_2222 | 1925 | 2348.0 | Domain | Protein kinase | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 1951_1959 | 1925 | 2348.0 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CEP85L | chr6:118802942 | chr6:117641193 | ENST00000360290 | - | 1 | 6 | 439_682 | 0 | 395.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | CEP85L | chr6:118802942 | chr6:117641193 | ENST00000368488 | - | 9 | 14 | 439_682 | 584 | 809.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | CEP85L | chr6:118802942 | chr6:117641193 | ENST00000368491 | - | 8 | 13 | 439_682 | 581 | 806.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | CEP85L | chr6:118802942 | chr6:117641193 | ENST00000392500 | - | 1 | 8 | 439_682 | 0 | 500.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | CEP85L | chr6:118802942 | chr6:117641193 | ENST00000419517 | - | 1 | 6 | 439_682 | 0 | 497.0 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 101_196 | 1925 | 2348.0 | Domain | Fibronectin type-III 1 | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 1043_1150 | 1925 | 2348.0 | Domain | Fibronectin type-III 5 | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 1450_1556 | 1925 | 2348.0 | Domain | Fibronectin type-III 6 | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 1557_1656 | 1925 | 2348.0 | Domain | Fibronectin type-III 7 | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 1658_1751 | 1925 | 2348.0 | Domain | Fibronectin type-III 8 | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 1752_1854 | 1925 | 2348.0 | Domain | Fibronectin type-III 9 | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 197_285 | 1925 | 2348.0 | Domain | Fibronectin type-III 2 | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 557_671 | 1925 | 2348.0 | Domain | Fibronectin type-III 3 | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 947_1042 | 1925 | 2348.0 | Domain | Fibronectin type-III 4 | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 1883_2347 | 1925 | 2348.0 | Topological domain | Cytoplasmic | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 28_1859 | 1925 | 2348.0 | Topological domain | Extracellular | |
Tgene | ROS1 | chr6:118802942 | chr6:117641193 | ENST00000368508 | 34 | 43 | 1860_1882 | 1925 | 2348.0 | Transmembrane | Helical |
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Fusion Gene Sequence for CEP85L-ROS1 |
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>15916_15916_1_CEP85L-ROS1_CEP85L_chr6_118802942_ENST00000368491_ROS1_chr6_117641193_ENST00000368507_length(transcript)=3826nt_BP=2367nt GGGAGGGCGTGAGGGATTACCCAAGGGAGGGGCGAGTATCGCAAAATAGGCCAAGTCGCTGCCCTCTACTCAACTCGCAGGGCGGGAGGA TGGAGACAGAGGGATGCGGCGGGAGGGCGGGACAGCCCAGTCGCCGCCAAGGAGGCGAAGCGGGGTCGGGGTAGCTCACCCGCCCCCCGC AGTCCCCGCCCCCCGCAGTCCCCGCCCCGCGCGGCGCCGCGCACGCCTGAAGTCATTGCCCGAGGCCCCGCCCCCTCGCGGCCCCAGCCC CGGCTCTGGCTCTGCCGGCGGAGGGGGCGGAGAGAACCCGCAGCTGCAACTTCGCCTGGAGCCTTTGAGCCTGGGCTCAGCCGGGGATCT AGCAGCCGTCACCGCCGAGTCGCCGCTTCCCCGGCGCGGGCCTCAGCCCAGCCGGCTTGGCCATGGCAGGCGCCGGCAGTGCGGCGAATC TGGCCCCTGCGCTCCCCGCCCGTAGCTGAGCAGCCGTTAACCAGCCATCCCGCCTTTCCTCCTGCCCGTGTCGCCGAGGCCCACGCTCCG CGCAAGTTTCCGCCGCCGAAGAAGCAGGAGGACGGACGTGAGGAGTCGGGCGTCCCTGGCCCACCCGGCCCTCTCGCCCGCGATGTGGGG GCGCTTCCTGGCTCCGGAGGCCAGCGGCCGGGATAGCCCCGGCGGAGCCCGCAGCTTCCCTGCCGGCCCAGATTATTCATCAGCATGGCT ACCTGCTAATGAATCATTGTGGCAGGCCACAACTGTTCCATCTAACCATCGAAATAACCATATCAGGAGACACAGTATAGCTTCTGACAG TGGAGACACTGGCATTGGAACTTCCTGTTCTGATAGCGTGGAAGATCATTCAACTTCAAGTGGCACATTATCTTTTAAGCCTAGTCAATC ATTGATTACTCTTCCTACTGCCCATGTGATGCCGTCTAATTCCAGCGCTTCAATTTCCAAACTTAGGGAATCATTGACACCAGATGGCTC AAAATGGAGTACAAGCCTCATGCAAACATTGGGAAACCACAGTAGGGGGGAGCAGGACTCTTCCCTAGACATGAAGGACTTCCGGCCACT TCGGAAATGGTCATCTTTATCCAAACTCACTGCCCCGGATAACTGTGGCCAGGGTGGCACTGTATGCAGAGAAGAGTCAAGGAATGGTTT GGAGAAGATAGGGAAGGCTAAGGCTTTAACATCACAACTGAGGACAATTGGGCCTAGCTGTTTACATGATAGTATGGAGATGCTTAGGTT AGAGGACAAGGAAATAAATAAAAAACGGTCATCAACTCTGGACTGCAAGTATAAATTTGAGAGCTGTAGCAAGGAGGACTTTAGAGCCTC TTCCTCTACTCTTAGGAGACAGCCTGTAGACATGACATATAGTGCCTTACCTGAAAGCAAGCCCATTATGACAAGCTCAGAGGCTTTTGA ACCTCCAAAATATTTAATGCTTGGTCAACAGGCAGTAGGTGGAGTTCCCATTCAGCCTTCCGTAAGGACTCAGATGTGGCTTACAGAGCA GCTGCGGACAAATCCTTTGGAAGGTAGAAATACAGAGGATTCTTACAGTTTAGCTCCTTGGCAACAGCAGCAAATTGAAGACTTTCGACA AGGAAGTGAAACACCAATGCAGGTTTTGACTGGATCATCTCGTCAAAGTTATTCACCTGGCTATCAGGATTTCAGTAAGTGGGAATCAAT GTTGAAAATAAAAGAAGGACTTCTAAGGCAGAAAGAAATTGTAATCGATCGGCAGAAGCAACAAATTACCCACCTGCATGAGAGGATAAG GGATAATGAATTACGGGCTCAACATGCCATGTTAGGACATTATGTAAATTGTGAGGATTCTTATGTGGCTAGTTTGCAGCCACAATATGA GAACACTTCACTCCAGACACCATTTTCAGAGGAATCAGTTTCCCATTCCCAACAAGGGGAATTTGAGCAAAAGCTTGCATCTACTGAGAA AGAAGTTTTACAGCTTAATGAGTTTCTCAAACAAAGACTAAGCCTATTTAGTGAAGAGAAGAAGAAACTAGAGGAAAAACTTAAAACTAG AGATCGATACATCAGTAGTCTGAAAAAGAAATGCCAGAAGGAATCTGAACAAAACAAAGAAAAGCAGAGAAGAATTGAGACCTTGGAAAA GTATCTGGCTGATCTTCCAACTCTAGATGATGTACAGAGTCAGAGTCTACAGCTGCAGATTCTGGAAGAAAAAAATAAGAATTTACAAGA GGCTTTGATAGATACAGAAAAAAAACTTGAAGAGATCAAAAAGCAGTGTCAAGATAAAGAGACACAGTTAATATGCCAGAAAAAGAAAGA AAAGGAGTTAGTAACTACCGTTCAGAGTACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGACTCT GCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAAAGT AGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCAAATTTAATCATCC CAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTACTTA TTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATATTTCAAAAGGCTG TGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACGGAT AGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGCTCCCAGTTCGGTG GATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGGAGATTTTAACTCT TGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCACCAAGAAATTGTCC TGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCAGTT ATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCTTTGAAGGTGAAGA TGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGTACT TGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGAGGAAAGAAGAGAA GGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTGTCT CACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCATTCAGTAGTTACTG AAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCTAATCTTGGTTCTG >15916_15916_1_CEP85L-ROS1_CEP85L_chr6_118802942_ENST00000368491_ROS1_chr6_117641193_ENST00000368507_length(amino acids)=1040AA_BP=1 MPVSPRPTLRASFRRRRSRRTDVRSRASLAHPALSPAMWGRFLAPEASGRDSPGGARSFPAGPDYSSAWLPANESLWQATTVPSNHRNNH IRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLITLPTAHVMPSNSSASISKLRESLTPDGSKWSTSLMQTLGNHSRGEQDS SLDMKDFRPLRKWSSLSKLTAPDNCGQGGTVCREESRNGLEKIGKAKALTSQLRTIGPSCLHDSMEMLRLEDKEINKKRSSTLDCKYKFE SCSKEDFRASSSTLRRQPVDMTYSALPESKPIMTSSEAFEPPKYLMLGQQAVGGVPIQPSVRTQMWLTEQLRTNPLEGRNTEDSYSLAPW QQQQIEDFRQGSETPMQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIRDNELRAQHAMLGHYVNCEDS YVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKLKTRDRYISSLKKKCQKESEQNKE KQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDKETQLICQKKKEKELVTTVQSTLPTQEEIENL PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILE LMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPT FHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQES -------------------------------------------------------------- >15916_15916_2_CEP85L-ROS1_CEP85L_chr6_118802942_ENST00000368491_ROS1_chr6_117641193_ENST00000368508_length(transcript)=3826nt_BP=2367nt GGGAGGGCGTGAGGGATTACCCAAGGGAGGGGCGAGTATCGCAAAATAGGCCAAGTCGCTGCCCTCTACTCAACTCGCAGGGCGGGAGGA TGGAGACAGAGGGATGCGGCGGGAGGGCGGGACAGCCCAGTCGCCGCCAAGGAGGCGAAGCGGGGTCGGGGTAGCTCACCCGCCCCCCGC AGTCCCCGCCCCCCGCAGTCCCCGCCCCGCGCGGCGCCGCGCACGCCTGAAGTCATTGCCCGAGGCCCCGCCCCCTCGCGGCCCCAGCCC CGGCTCTGGCTCTGCCGGCGGAGGGGGCGGAGAGAACCCGCAGCTGCAACTTCGCCTGGAGCCTTTGAGCCTGGGCTCAGCCGGGGATCT AGCAGCCGTCACCGCCGAGTCGCCGCTTCCCCGGCGCGGGCCTCAGCCCAGCCGGCTTGGCCATGGCAGGCGCCGGCAGTGCGGCGAATC TGGCCCCTGCGCTCCCCGCCCGTAGCTGAGCAGCCGTTAACCAGCCATCCCGCCTTTCCTCCTGCCCGTGTCGCCGAGGCCCACGCTCCG CGCAAGTTTCCGCCGCCGAAGAAGCAGGAGGACGGACGTGAGGAGTCGGGCGTCCCTGGCCCACCCGGCCCTCTCGCCCGCGATGTGGGG GCGCTTCCTGGCTCCGGAGGCCAGCGGCCGGGATAGCCCCGGCGGAGCCCGCAGCTTCCCTGCCGGCCCAGATTATTCATCAGCATGGCT ACCTGCTAATGAATCATTGTGGCAGGCCACAACTGTTCCATCTAACCATCGAAATAACCATATCAGGAGACACAGTATAGCTTCTGACAG TGGAGACACTGGCATTGGAACTTCCTGTTCTGATAGCGTGGAAGATCATTCAACTTCAAGTGGCACATTATCTTTTAAGCCTAGTCAATC ATTGATTACTCTTCCTACTGCCCATGTGATGCCGTCTAATTCCAGCGCTTCAATTTCCAAACTTAGGGAATCATTGACACCAGATGGCTC AAAATGGAGTACAAGCCTCATGCAAACATTGGGAAACCACAGTAGGGGGGAGCAGGACTCTTCCCTAGACATGAAGGACTTCCGGCCACT TCGGAAATGGTCATCTTTATCCAAACTCACTGCCCCGGATAACTGTGGCCAGGGTGGCACTGTATGCAGAGAAGAGTCAAGGAATGGTTT GGAGAAGATAGGGAAGGCTAAGGCTTTAACATCACAACTGAGGACAATTGGGCCTAGCTGTTTACATGATAGTATGGAGATGCTTAGGTT AGAGGACAAGGAAATAAATAAAAAACGGTCATCAACTCTGGACTGCAAGTATAAATTTGAGAGCTGTAGCAAGGAGGACTTTAGAGCCTC TTCCTCTACTCTTAGGAGACAGCCTGTAGACATGACATATAGTGCCTTACCTGAAAGCAAGCCCATTATGACAAGCTCAGAGGCTTTTGA ACCTCCAAAATATTTAATGCTTGGTCAACAGGCAGTAGGTGGAGTTCCCATTCAGCCTTCCGTAAGGACTCAGATGTGGCTTACAGAGCA GCTGCGGACAAATCCTTTGGAAGGTAGAAATACAGAGGATTCTTACAGTTTAGCTCCTTGGCAACAGCAGCAAATTGAAGACTTTCGACA AGGAAGTGAAACACCAATGCAGGTTTTGACTGGATCATCTCGTCAAAGTTATTCACCTGGCTATCAGGATTTCAGTAAGTGGGAATCAAT GTTGAAAATAAAAGAAGGACTTCTAAGGCAGAAAGAAATTGTAATCGATCGGCAGAAGCAACAAATTACCCACCTGCATGAGAGGATAAG GGATAATGAATTACGGGCTCAACATGCCATGTTAGGACATTATGTAAATTGTGAGGATTCTTATGTGGCTAGTTTGCAGCCACAATATGA GAACACTTCACTCCAGACACCATTTTCAGAGGAATCAGTTTCCCATTCCCAACAAGGGGAATTTGAGCAAAAGCTTGCATCTACTGAGAA AGAAGTTTTACAGCTTAATGAGTTTCTCAAACAAAGACTAAGCCTATTTAGTGAAGAGAAGAAGAAACTAGAGGAAAAACTTAAAACTAG AGATCGATACATCAGTAGTCTGAAAAAGAAATGCCAGAAGGAATCTGAACAAAACAAAGAAAAGCAGAGAAGAATTGAGACCTTGGAAAA GTATCTGGCTGATCTTCCAACTCTAGATGATGTACAGAGTCAGAGTCTACAGCTGCAGATTCTGGAAGAAAAAAATAAGAATTTACAAGA GGCTTTGATAGATACAGAAAAAAAACTTGAAGAGATCAAAAAGCAGTGTCAAGATAAAGAGACACAGTTAATATGCCAGAAAAAGAAAGA AAAGGAGTTAGTAACTACCGTTCAGAGTACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGACTCT GCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAAAGT AGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCAAATTTAATCATCC CAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTACTTA TTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATATTTCAAAAGGCTG TGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACGGAT AGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGCTCCCAGTTCGGTG GATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGGAGATTTTAACTCT TGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCACCAAGAAATTGTCC TGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCAGTT ATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCTTTGAAGGTGAAGA TGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGTACT TGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGAGGAAAGAAGAGAA GGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTGTCT CACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCATTCAGTAGTTACTG AAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCTAATCTTGGTTCTG >15916_15916_2_CEP85L-ROS1_CEP85L_chr6_118802942_ENST00000368491_ROS1_chr6_117641193_ENST00000368508_length(amino acids)=1040AA_BP=1 MPVSPRPTLRASFRRRRSRRTDVRSRASLAHPALSPAMWGRFLAPEASGRDSPGGARSFPAGPDYSSAWLPANESLWQATTVPSNHRNNH IRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLITLPTAHVMPSNSSASISKLRESLTPDGSKWSTSLMQTLGNHSRGEQDS SLDMKDFRPLRKWSSLSKLTAPDNCGQGGTVCREESRNGLEKIGKAKALTSQLRTIGPSCLHDSMEMLRLEDKEINKKRSSTLDCKYKFE SCSKEDFRASSSTLRRQPVDMTYSALPESKPIMTSSEAFEPPKYLMLGQQAVGGVPIQPSVRTQMWLTEQLRTNPLEGRNTEDSYSLAPW QQQQIEDFRQGSETPMQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIRDNELRAQHAMLGHYVNCEDS YVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKLKTRDRYISSLKKKCQKESEQNKE KQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDKETQLICQKKKEKELVTTVQSTLPTQEEIENL PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILE LMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPT FHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQES -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CEP85L-ROS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CEP85L-ROS1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ROS1 | P08922 | DB11986 | Entrectinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | ROS1 | P08922 | DB11986 | Entrectinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | ROS1 | P08922 | DB11986 | Entrectinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | ROS1 | P08922 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | ROS1 | P08922 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | ROS1 | P08922 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for CEP85L-ROS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0007131 | Non-Small Cell Lung Carcinoma | 4 | CTD_human | |
Tgene | C0017638 | Glioma | 1 | CTD_human | |
Tgene | C0025202 | melanoma | 1 | CTD_human | |
Tgene | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CGI;CTD_human | |
Tgene | C0259783 | mixed gliomas | 1 | CTD_human | |
Tgene | C0555198 | Malignant Glioma | 1 | CTD_human |