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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NHLRC3-PAK1 (FusionGDB2 ID:HG387921TG5058)

Fusion Gene Summary for NHLRC3-PAK1

check button Fusion gene summary
Fusion gene informationFusion gene name: NHLRC3-PAK1
Fusion gene ID: hg387921tg5058
HgeneTgene
Gene symbol

NHLRC3

PAK1

Gene ID

387921

5058

Gene nameNHL repeat containing 3p21 (RAC1) activated kinase 1
Synonyms-IDDMSSD|PAKalpha|alpha-PAK|p65-PAK
Cytomap('NHLRC3')('PAK1')

13q13.3

11q13.5-q14.1

Type of geneprotein-codingprotein-coding
DescriptionNHL repeat-containing protein 3serine/threonine-protein kinase PAK 1STE20 homolog, yeastp21 protein (Cdc42/Rac)-activated kinase 1p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
Modification date2020031320200327
UniProtAcc

Q5JS37

.
Ensembl transtripts involved in fusion geneENST00000379599, ENST00000379600, 
ENST00000470258, 
Fusion gene scores* DoF score8 X 3 X 4=9622 X 17 X 10=3740
# samples 726
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/3740*10)=-3.84645474174655
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NHLRC3 [Title/Abstract] AND PAK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNHLRC3(39613848)-PAK1(77091039), # samples:1
Anticipated loss of major functional domain due to fusion event.NHLRC3-PAK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NHLRC3-PAK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePAK1

GO:0000165

MAPK cascade

8805275

TgenePAK1

GO:0006338

chromatin remodeling

23260667

TgenePAK1

GO:0006468

protein phosphorylation

9852149|23260667

TgenePAK1

GO:0006974

cellular response to DNA damage stimulus

23260667

TgenePAK1

GO:0030335

positive regulation of cell migration

25766321

TgenePAK1

GO:0031532

actin cytoskeleton reorganization

9395435

TgenePAK1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgenePAK1

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

16278681

TgenePAK1

GO:0046777

protein autophosphorylation

8805275


check buttonFusion gene breakpoints across NHLRC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PAK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8078-01ANHLRC3chr13

39613848

+PAK1chr11

77091039

-


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Fusion Gene ORF analysis for NHLRC3-PAK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000379599ENST00000528203NHLRC3chr13

39613848

+PAK1chr11

77091039

-
5CDS-5UTRENST00000379600ENST00000528203NHLRC3chr13

39613848

+PAK1chr11

77091039

-
5CDS-intronENST00000379599ENST00000525542NHLRC3chr13

39613848

+PAK1chr11

77091039

-
5CDS-intronENST00000379600ENST00000525542NHLRC3chr13

39613848

+PAK1chr11

77091039

-
5UTR-3CDSENST00000470258ENST00000278568NHLRC3chr13

39613848

+PAK1chr11

77091039

-
5UTR-3CDSENST00000470258ENST00000356341NHLRC3chr13

39613848

+PAK1chr11

77091039

-
5UTR-3CDSENST00000470258ENST00000530617NHLRC3chr13

39613848

+PAK1chr11

77091039

-
5UTR-5UTRENST00000470258ENST00000528203NHLRC3chr13

39613848

+PAK1chr11

77091039

-
5UTR-intronENST00000470258ENST00000525542NHLRC3chr13

39613848

+PAK1chr11

77091039

-
In-frameENST00000379599ENST00000278568NHLRC3chr13

39613848

+PAK1chr11

77091039

-
In-frameENST00000379599ENST00000356341NHLRC3chr13

39613848

+PAK1chr11

77091039

-
In-frameENST00000379599ENST00000530617NHLRC3chr13

39613848

+PAK1chr11

77091039

-
In-frameENST00000379600ENST00000278568NHLRC3chr13

39613848

+PAK1chr11

77091039

-
In-frameENST00000379600ENST00000356341NHLRC3chr13

39613848

+PAK1chr11

77091039

-
In-frameENST00000379600ENST00000530617NHLRC3chr13

39613848

+PAK1chr11

77091039

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379600NHLRC3chr1339613848+ENST00000356341PAK1chr1177091039-37227071452154669
ENST00000379600NHLRC3chr1339613848+ENST00000530617PAK1chr1177091039-32067071452085646
ENST00000379600NHLRC3chr1339613848+ENST00000278568PAK1chr1177091039-25307071452178677
ENST00000379599NHLRC3chr1339613848+ENST00000356341PAK1chr1177091039-3649634722081669
ENST00000379599NHLRC3chr1339613848+ENST00000530617PAK1chr1177091039-3133634722012646
ENST00000379599NHLRC3chr1339613848+ENST00000278568PAK1chr1177091039-2457634722105677

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379600ENST00000356341NHLRC3chr1339613848+PAK1chr1177091039-0.000968880.9990312
ENST00000379600ENST00000530617NHLRC3chr1339613848+PAK1chr1177091039-0.0011157310.99888426
ENST00000379600ENST00000278568NHLRC3chr1339613848+PAK1chr1177091039-0.0018545820.99814546
ENST00000379599ENST00000356341NHLRC3chr1339613848+PAK1chr1177091039-0.0009870740.99901295
ENST00000379599ENST00000530617NHLRC3chr1339613848+PAK1chr1177091039-0.0011183780.99888164
ENST00000379599ENST00000278568NHLRC3chr1339613848+PAK1chr1177091039-0.0018592230.9981408

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Fusion Genomic Features for NHLRC3-PAK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for NHLRC3-PAK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:39613848/chr11:77091039)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NHLRC3

Q5JS37

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNHLRC3chr13:39613848chr11:77091039ENST00000379599+3647_93128281.0RepeatNote=NHL 1
HgeneNHLRC3chr13:39613848chr11:77091039ENST00000379600+3747_93128348.0RepeatNote=NHL 1
TgenePAK1chr13:39613848chr11:77091039ENST00000278568116270_52163554.0DomainProtein kinase
TgenePAK1chr13:39613848chr11:77091039ENST0000027856811675_8863554.0DomainCRIB
TgenePAK1chr13:39613848chr11:77091039ENST00000356341115270_52163546.0DomainProtein kinase
TgenePAK1chr13:39613848chr11:77091039ENST0000035634111575_8863546.0DomainCRIB
TgenePAK1chr13:39613848chr11:77091039ENST00000278568116276_28463554.0Nucleotide bindingNote=ATP
TgenePAK1chr13:39613848chr11:77091039ENST00000278568116345_34763554.0Nucleotide bindingNote=ATP
TgenePAK1chr13:39613848chr11:77091039ENST00000356341115276_28463546.0Nucleotide bindingNote=ATP
TgenePAK1chr13:39613848chr11:77091039ENST00000356341115345_34763546.0Nucleotide bindingNote=ATP
TgenePAK1chr13:39613848chr11:77091039ENST0000027856811670_14063554.0RegionNote=Autoregulatory region
TgenePAK1chr13:39613848chr11:77091039ENST0000027856811675_10563554.0RegionNote=GTPase-binding
TgenePAK1chr13:39613848chr11:77091039ENST0000035634111570_14063546.0RegionNote=Autoregulatory region
TgenePAK1chr13:39613848chr11:77091039ENST0000035634111575_10563546.0RegionNote=GTPase-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNHLRC3chr13:39613848chr11:77091039ENST00000379599+36150_196128281.0RepeatNote=NHL 2
HgeneNHLRC3chr13:39613848chr11:77091039ENST00000379599+36200_243128281.0RepeatNote=NHL 3
HgeneNHLRC3chr13:39613848chr11:77091039ENST00000379599+36294_338128281.0RepeatNote=NHL 4
HgeneNHLRC3chr13:39613848chr11:77091039ENST00000379600+37150_196128348.0RepeatNote=NHL 2
HgeneNHLRC3chr13:39613848chr11:77091039ENST00000379600+37200_243128348.0RepeatNote=NHL 3
HgeneNHLRC3chr13:39613848chr11:77091039ENST00000379600+37294_338128348.0RepeatNote=NHL 4


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Fusion Gene Sequence for NHLRC3-PAK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59077_59077_1_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379599_PAK1_chr11_77091039_ENST00000278568_length(transcript)=2457nt_BP=634nt
ACCTGACATGAGGGCGGGGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTT
CGTACTCAAAGCTCGTGCATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTG
CAGCCTGAGGCTGTCAGGTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGC
GTAGCCGGTGCTGGCTTCTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTT
TCCTGGAGAACTGAGAAAATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCA
GTTGACTCCCTCAATGGATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTA
CGAGCCTGGAATTATACAGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGA
AGTGCAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTC
ACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAG
GCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATAAGTCAGCTGAGGAT
TACAATTCTTCTAATGCCTTGAATGTGAAGGCTGTGTCTGAGACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGAT
GATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGAGCACACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACT
CCAACTCGGGACGTGGCTACATCTCCCATTTCACCTACTGAAAATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAG
AAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGAGAAATTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGG
TTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTACACAGCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAAT
CTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGAGATCCTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGAC
AGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGAATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGAT
GAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCAGGCTCTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGT
GACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCTAACTGACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGC
ACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGTTGTGACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATC
ATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCTCAATGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCA
GAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCGGGACTTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCT
AAAGAGCTGCTACAGGTGAGAAAACTGAGGTTTCAAGTGTTTAGTAACTTTTCCATGATAGCTGCATCAATTCCTGAAGATTGCCAAGCC
CCTCTCCAGCCTCACTCCACTGATTGCTGCAGCTAAGGAGGCAACAAAGAACAATCACTAAAACCACACTCACCCCAGCCTCATTGTGCC
AAGCCTTCTGTGAGATAAATGCACATTTCAGAAATTCCAACTCCTGATGCCCTCTTCTCCTTGCCTTGCTTCTCCCATTTCCTGATCTAG
CACTCCTCAAGACTTTGATCCTTGGAAACCGTGTGTCCAGCATTGAAGAGAACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTA
AATAAGGAATTTCCTCCCAATTCATGGATATGAGGGTGGTTTATGATTAAGGGTTTATATAAATAAATGTTTCTAGTCTTCCGTGTGTCA
AAATCCTCACCTCCTTCATAACCATCT

>59077_59077_1_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379599_PAK1_chr11_77091039_ENST00000278568_length(amino acids)=677AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSANKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT
DKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALT
RNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN
IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP
EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDV
EKRGSAKELLQVRKLRFQVFSNFSMIAASIPEDCQAPLQPHSTDCCS

--------------------------------------------------------------
>59077_59077_2_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379599_PAK1_chr11_77091039_ENST00000356341_length(transcript)=3649nt_BP=634nt
ACCTGACATGAGGGCGGGGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTT
CGTACTCAAAGCTCGTGCATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTG
CAGCCTGAGGCTGTCAGGTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGC
GTAGCCGGTGCTGGCTTCTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTT
TCCTGGAGAACTGAGAAAATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCA
GTTGACTCCCTCAATGGATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTA
CGAGCCTGGAATTATACAGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGA
AGTGCAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTC
ACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAG
GCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATAAGTCAGCTGAGGAT
TACAATTCTTCTAATGCCTTGAATGTGAAGGCTGTGTCTGAGACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGAT
GATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGAGCACACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACT
CCAACTCGGGACGTGGCTACATCTCCCATTTCACCTACTGAAAATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAG
AAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGAGAAATTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGG
TTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTACACAGCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAAT
CTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGAGATCCTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGAC
AGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGAATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGAT
GAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCAGGCTCTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGT
GACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCTAACTGACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGC
ACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGTTGTGACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATC
ATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCTCAATGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCA
GAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCGGGACTTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCT
AAAGAGCTGCTACAGCATCAATTCCTGAAGATTGCCAAGCCCCTCTCCAGCCTCACTCCACTGATTGCTGCAGCTAAGGAGGCAACAAAG
AACAATCACTAAAACCACACTCACCCCAGCCTCATTGTGCCAAGCCTTCTGTGAGATAAATGCACATTTCAGAAATTCCAACTCCTGATG
CCCTCTTCTCCTTGCCTTGCTTCTCCCATTTCCTGATCTAGCACTCCTCAAGACTTTGATCCTTGGAAACCGTGTGTCCAGCATTGAAGA
GAACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTAAATAAGGAATTTCCTCCCAATTCATGGATATGAGGGTGGTTTATGATTA
AGGGTTTATATAAATAAATGTTTCTAGTCTTCCGTGTGTCAAAATCCTCACCTCCTTCATAACCATCTCCCACAATTAATTCTTGACTAT
ATAAATTTATGGTTTGATAATATTATCAATTTGTAATCAATTGAGATTTCTTTAGTGCTTGCTTTTCTGTGACTCAACTGCCCAGACACC
TCATTGTACTTGAAAACTGGAACAGCTTGGGAATGCCATGGGGTTTGATAATCTGCCAGGGACATGAAGAGGCTCAGCTTCCTGGACCAT
GACTTTGGCTCAGCTGATCCTGACATGGGAGAACAACCACATTTTTCTTTGTGTGTGCTTCTAGCAGCTGTTCGGGAGGACCTTGACCCA
ATAGTGTTCCCATGCTGTTTCTTGTGAAATGCTCTCGGCTATGTAGCAGCTTTTGATTCCCTGCATACCCTAGGCTGCTGCCCCTATCCT
GTCCCTTGTTTATAACATTGAGAGGTTTTCTAGGGCACATACTGAGTGAGAGCAGTGTTGAGAAGTCGGGGAAAATGGTGACTACTTTTA
GAGCAAGGCTGGGCATCAGCACCTGTCCAGCTCTACTTGTGTGATGTTTCAGGAACTCAGCCCCTTTTTCTGCCTAGGATAAGGAGCTGA
AAGATTAACTTGGATCTTCTAATGGTCCAAATCTTTTGGTCACAATAAAGAGTCTCCAAATTAGAGACTGCATGTTAGTTCTGGATGGAT
TTGGTGGCCTGACATGATACCCTGCCAGCTGTGAGGGGACCCCGTTTTTAAGATGCATGGCCAAGCTCTCTGCAAATGGAAATGCTTACA
CTGGGTGTTGGGGATGTTTGCTACCTCCTGCTATTTTTGTGGTTTTGGTTCTCCCACTATGGTAGGACCCCTGGCCAGCATTGTGGCTTG
TCATGTCAGCCCCATTGACTACCTTCTCATGCTCTGAGGTACTACTGCCTCTGCAGCACAAATTTCTATTTCTGTCAATAAAAGGAGATG
AAAATATTCTATTGGAGTATGCCTTTCTTTTTTCTCTTCGTTTTTTCTTTCCTTTTCTAATTTTTTATATGAAATAATGAGTAGTTTCTT
CCTGAACCATTTGAGAGTGGTAAGTTGCAGATAGAATGCCCCTTTACCACTATATACCTGAATGTGTATTCTTTCTTTTTAACACTTTTA
TTTTAAATATAAATTAAGAGAAATGGGCCAAAACCATTTGTATTGTTTAAAGAATAATTATAAACACACTTGTATCCACCAAATCAAGAA
ATGGAACACTGACAGTAAGAACCTTCTCTATCTTGTCCTTCCTTTCTCA

>59077_59077_2_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379599_PAK1_chr11_77091039_ENST00000356341_length(amino acids)=669AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSANKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT
DKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALT
RNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN
IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP
EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDV
EKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH

--------------------------------------------------------------
>59077_59077_3_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379599_PAK1_chr11_77091039_ENST00000530617_length(transcript)=3133nt_BP=634nt
ACCTGACATGAGGGCGGGGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTT
CGTACTCAAAGCTCGTGCATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTG
CAGCCTGAGGCTGTCAGGTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGC
GTAGCCGGTGCTGGCTTCTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTT
TCCTGGAGAACTGAGAAAATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCA
GTTGACTCCCTCAATGGATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTA
CGAGCCTGGAATTATACAGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGA
AGTGCAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTC
ACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAG
GCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATAAGTCAGCTGAGGAT
TACAATTCTTCTAATGCCTTGAATGTGAAGGCTGTGTCTGAGACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGAT
GATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGAGCACACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACT
CCAACTCGGGACGTGGCTACATCTCCCATTTCACCTACTGAAAATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAG
AAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGAGAAATTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGG
TTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTACACAGCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAAT
CTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGAGATCCTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGAC
AGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGAATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGAT
GAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCAGGCTCTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGT
GACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCTAACTGACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGC
ACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGTTGTGACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATC
ATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCTCAATGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCA
GAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCGGGACTTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCT
AAAGAGCTGCTACAGCACTCCTCAAGACTTTGATCCTTGGAAACCGTGTGTCCAGCATTGAAGAGAACTGCAACTGAATGACTAATCAGA
TGATGGCCATTTCTAAATAAGGAATTTCCTCCCAATTCATGGATATGAGGGTGGTTTATGATTAAGGGTTTATATAAATAAATGTTTCTA
GTCTTCCGTGTGTCAAAATCCTCACCTCCTTCATAACCATCTCCCACAATTAATTCTTGACTATATAAATTTATGGTTTGATAATATTAT
CAATTTGTAATCAATTGAGATTTCTTTAGTGCTTGCTTTTCTGTGACTCAACTGCCCAGACACCTCATTGTACTTGAAAACTGGAACAGC
TTGGGAATGCCATGGGGTTTGATAATCTGCCAGGGACATGAAGAGGCTCAGCTTCCTGGACCATGACTTTGGCTCAGCTGATCCTGACAT
GGGAGAACAACCACATTTTTCTTTGTGTGTGCTTCTAGCAGCTGTTCGGGAGGACCTTGACCCAATAGTGTTCCCATGCTGTTTCTTGTG
AAATGCTCTCGGCTATGTAGCAGCTTTTGATTCCCTGCATACCCTAGGCTGCTGCCCCTATCCTGTCCCTTGTTTATAACATTGAGAGGT
TTTCTAGGGCACATACTGAGTGAGAGCAGTGTTGAGAAGTCGGGGAAAATGGTGACTACTTTTAGAGCAAGGCTGGGCATCAGCACCTGT
CCAGCTCTACTTGTGTGATGTTTCAGGAACTCAGCCCCTTTTTCTGCCTAGGATAAGGAGCTGAAAGATTAACTTGGATCTTCTAATGGT
CCAAATCTTTTGGTCACAATAAAGAGTCTCCAAATTAGAGACTGCATGTTAGTTCTGGATGGATTTGGTGGCCTGACATGATACCCTGCC
AGCTGTGAGGGGACCCCGTTTTTAAGATGCATGGCCAAGCTCTCTGCAAATGGAAATGCTTACACTGGGTGTTGGGGATGTTTGCTACCT
CCTGCTATTTTTGTGGTTTTGGTTCTCCCACTATGGTAGGACCCCTGGCCAGCATTGTGGCTTGTCATGTCAGCCCCATTGACTACCTTC
TCATGCTCTGAGGTACTACTGCCTCTGCAGCACAAATTTCTATTTCTGTCAATAAAAGGAGATGAAAATATTC

>59077_59077_3_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379599_PAK1_chr11_77091039_ENST00000530617_length(amino acids)=646AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSANKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT
DKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALT
RNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN
IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP
EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDV
EKRGSAKELLQHSSRL

--------------------------------------------------------------
>59077_59077_4_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379600_PAK1_chr11_77091039_ENST00000278568_length(transcript)=2530nt_BP=707nt
GGTGGCCACTGAAAGTCAGCGGCGCGGACTGCCCTGAGGGCGGGAAAGGGTGGTCACTGGGTCAGCCCGAAGCACCTGACATGAGGGCGG
GGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTTCGTACTCAAAGCTCGTG
CATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTGCAGCCTGAGGCTGTCAG
GTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGCGTAGCCGGTGCTGGCTT
CTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTTTCCTGGAGAACTGAGAA
AATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCAGTTGACTCCCTCAATGG
ATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTACGAGCCTGGAATTATAC
AGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGAAGTGCAAATAAAAAGAA
AGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAGGGGAGTTTACGGG
AATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTT
GGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATAAGTCAGCTGAGGATTACAATTCTTCTAATGC
CTTGAATGTGAAGGCTGTGTCTGAGACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACC
AGTGATTGCTCCACGCCCAGAGCACACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGC
TACATCTCCCATTTCACCTACTGAAAATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAAT
GTCTGATGAGGAGATCTTGGAGAAATTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACA
AGGTGCTTCAGGCACCGTGTACACAGCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAA
GAAAGAGCTGATTATTAATGAGATCCTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGA
TGAGCTGTGGGTTGTTATGGAATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGC
TGTGTGCCGTGAGTGTCTGCAGGCTCTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGG
AATGGATGGCTCTGTCAAGCTAACTGACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCC
ATACTGGATGGCACCAGAGGTTGTGACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGAT
TGAAGGGGAGCCTCCATACCTCAATGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGA
GAAGCTGTCAGCTATCTTCCGGGACTTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGGT
GAGAAAACTGAGGTTTCAAGTGTTTAGTAACTTTTCCATGATAGCTGCATCAATTCCTGAAGATTGCCAAGCCCCTCTCCAGCCTCACTC
CACTGATTGCTGCAGCTAAGGAGGCAACAAAGAACAATCACTAAAACCACACTCACCCCAGCCTCATTGTGCCAAGCCTTCTGTGAGATA
AATGCACATTTCAGAAATTCCAACTCCTGATGCCCTCTTCTCCTTGCCTTGCTTCTCCCATTTCCTGATCTAGCACTCCTCAAGACTTTG
ATCCTTGGAAACCGTGTGTCCAGCATTGAAGAGAACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTAAATAAGGAATTTCCTCC
CAATTCATGGATATGAGGGTGGTTTATGATTAAGGGTTTATATAAATAAATGTTTCTAGTCTTCCGTGTGTCAAAATCCTCACCTCCTTC
ATAACCATCT

>59077_59077_4_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379600_PAK1_chr11_77091039_ENST00000278568_length(amino acids)=677AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSANKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT
DKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALT
RNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN
IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP
EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDV
EKRGSAKELLQVRKLRFQVFSNFSMIAASIPEDCQAPLQPHSTDCCS

--------------------------------------------------------------
>59077_59077_5_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379600_PAK1_chr11_77091039_ENST00000356341_length(transcript)=3722nt_BP=707nt
GGTGGCCACTGAAAGTCAGCGGCGCGGACTGCCCTGAGGGCGGGAAAGGGTGGTCACTGGGTCAGCCCGAAGCACCTGACATGAGGGCGG
GGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTTCGTACTCAAAGCTCGTG
CATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTGCAGCCTGAGGCTGTCAG
GTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGCGTAGCCGGTGCTGGCTT
CTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTTTCCTGGAGAACTGAGAA
AATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCAGTTGACTCCCTCAATGG
ATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTACGAGCCTGGAATTATAC
AGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGAAGTGCAAATAAAAAGAA
AGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAGGGGAGTTTACGGG
AATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTT
GGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATAAGTCAGCTGAGGATTACAATTCTTCTAATGC
CTTGAATGTGAAGGCTGTGTCTGAGACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACC
AGTGATTGCTCCACGCCCAGAGCACACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGC
TACATCTCCCATTTCACCTACTGAAAATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAAT
GTCTGATGAGGAGATCTTGGAGAAATTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACA
AGGTGCTTCAGGCACCGTGTACACAGCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAA
GAAAGAGCTGATTATTAATGAGATCCTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGA
TGAGCTGTGGGTTGTTATGGAATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGC
TGTGTGCCGTGAGTGTCTGCAGGCTCTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGG
AATGGATGGCTCTGTCAAGCTAACTGACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCC
ATACTGGATGGCACCAGAGGTTGTGACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGAT
TGAAGGGGAGCCTCCATACCTCAATGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGA
GAAGCTGTCAGCTATCTTCCGGGACTTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGCA
TCAATTCCTGAAGATTGCCAAGCCCCTCTCCAGCCTCACTCCACTGATTGCTGCAGCTAAGGAGGCAACAAAGAACAATCACTAAAACCA
CACTCACCCCAGCCTCATTGTGCCAAGCCTTCTGTGAGATAAATGCACATTTCAGAAATTCCAACTCCTGATGCCCTCTTCTCCTTGCCT
TGCTTCTCCCATTTCCTGATCTAGCACTCCTCAAGACTTTGATCCTTGGAAACCGTGTGTCCAGCATTGAAGAGAACTGCAACTGAATGA
CTAATCAGATGATGGCCATTTCTAAATAAGGAATTTCCTCCCAATTCATGGATATGAGGGTGGTTTATGATTAAGGGTTTATATAAATAA
ATGTTTCTAGTCTTCCGTGTGTCAAAATCCTCACCTCCTTCATAACCATCTCCCACAATTAATTCTTGACTATATAAATTTATGGTTTGA
TAATATTATCAATTTGTAATCAATTGAGATTTCTTTAGTGCTTGCTTTTCTGTGACTCAACTGCCCAGACACCTCATTGTACTTGAAAAC
TGGAACAGCTTGGGAATGCCATGGGGTTTGATAATCTGCCAGGGACATGAAGAGGCTCAGCTTCCTGGACCATGACTTTGGCTCAGCTGA
TCCTGACATGGGAGAACAACCACATTTTTCTTTGTGTGTGCTTCTAGCAGCTGTTCGGGAGGACCTTGACCCAATAGTGTTCCCATGCTG
TTTCTTGTGAAATGCTCTCGGCTATGTAGCAGCTTTTGATTCCCTGCATACCCTAGGCTGCTGCCCCTATCCTGTCCCTTGTTTATAACA
TTGAGAGGTTTTCTAGGGCACATACTGAGTGAGAGCAGTGTTGAGAAGTCGGGGAAAATGGTGACTACTTTTAGAGCAAGGCTGGGCATC
AGCACCTGTCCAGCTCTACTTGTGTGATGTTTCAGGAACTCAGCCCCTTTTTCTGCCTAGGATAAGGAGCTGAAAGATTAACTTGGATCT
TCTAATGGTCCAAATCTTTTGGTCACAATAAAGAGTCTCCAAATTAGAGACTGCATGTTAGTTCTGGATGGATTTGGTGGCCTGACATGA
TACCCTGCCAGCTGTGAGGGGACCCCGTTTTTAAGATGCATGGCCAAGCTCTCTGCAAATGGAAATGCTTACACTGGGTGTTGGGGATGT
TTGCTACCTCCTGCTATTTTTGTGGTTTTGGTTCTCCCACTATGGTAGGACCCCTGGCCAGCATTGTGGCTTGTCATGTCAGCCCCATTG
ACTACCTTCTCATGCTCTGAGGTACTACTGCCTCTGCAGCACAAATTTCTATTTCTGTCAATAAAAGGAGATGAAAATATTCTATTGGAG
TATGCCTTTCTTTTTTCTCTTCGTTTTTTCTTTCCTTTTCTAATTTTTTATATGAAATAATGAGTAGTTTCTTCCTGAACCATTTGAGAG
TGGTAAGTTGCAGATAGAATGCCCCTTTACCACTATATACCTGAATGTGTATTCTTTCTTTTTAACACTTTTATTTTAAATATAAATTAA
GAGAAATGGGCCAAAACCATTTGTATTGTTTAAAGAATAATTATAAACACACTTGTATCCACCAAATCAAGAAATGGAACACTGACAGTA
AGAACCTTCTCTATCTTGTCCTTCCTTTCTCA

>59077_59077_5_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379600_PAK1_chr11_77091039_ENST00000356341_length(amino acids)=669AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSANKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT
DKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALT
RNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN
IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP
EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDV
EKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH

--------------------------------------------------------------
>59077_59077_6_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379600_PAK1_chr11_77091039_ENST00000530617_length(transcript)=3206nt_BP=707nt
GGTGGCCACTGAAAGTCAGCGGCGCGGACTGCCCTGAGGGCGGGAAAGGGTGGTCACTGGGTCAGCCCGAAGCACCTGACATGAGGGCGG
GGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTTCGTACTCAAAGCTCGTG
CATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTGCAGCCTGAGGCTGTCAG
GTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGCGTAGCCGGTGCTGGCTT
CTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTTTCCTGGAGAACTGAGAA
AATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCAGTTGACTCCCTCAATGG
ATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTACGAGCCTGGAATTATAC
AGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGAAGTGCAAATAAAAAGAA
AGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAGGGGAGTTTACGGG
AATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTT
GGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATAAGTCAGCTGAGGATTACAATTCTTCTAATGC
CTTGAATGTGAAGGCTGTGTCTGAGACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACC
AGTGATTGCTCCACGCCCAGAGCACACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGC
TACATCTCCCATTTCACCTACTGAAAATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAAT
GTCTGATGAGGAGATCTTGGAGAAATTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACA
AGGTGCTTCAGGCACCGTGTACACAGCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAA
GAAAGAGCTGATTATTAATGAGATCCTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGA
TGAGCTGTGGGTTGTTATGGAATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGC
TGTGTGCCGTGAGTGTCTGCAGGCTCTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGG
AATGGATGGCTCTGTCAAGCTAACTGACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCC
ATACTGGATGGCACCAGAGGTTGTGACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGAT
TGAAGGGGAGCCTCCATACCTCAATGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGA
GAAGCTGTCAGCTATCTTCCGGGACTTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGCA
CTCCTCAAGACTTTGATCCTTGGAAACCGTGTGTCCAGCATTGAAGAGAACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTAAA
TAAGGAATTTCCTCCCAATTCATGGATATGAGGGTGGTTTATGATTAAGGGTTTATATAAATAAATGTTTCTAGTCTTCCGTGTGTCAAA
ATCCTCACCTCCTTCATAACCATCTCCCACAATTAATTCTTGACTATATAAATTTATGGTTTGATAATATTATCAATTTGTAATCAATTG
AGATTTCTTTAGTGCTTGCTTTTCTGTGACTCAACTGCCCAGACACCTCATTGTACTTGAAAACTGGAACAGCTTGGGAATGCCATGGGG
TTTGATAATCTGCCAGGGACATGAAGAGGCTCAGCTTCCTGGACCATGACTTTGGCTCAGCTGATCCTGACATGGGAGAACAACCACATT
TTTCTTTGTGTGTGCTTCTAGCAGCTGTTCGGGAGGACCTTGACCCAATAGTGTTCCCATGCTGTTTCTTGTGAAATGCTCTCGGCTATG
TAGCAGCTTTTGATTCCCTGCATACCCTAGGCTGCTGCCCCTATCCTGTCCCTTGTTTATAACATTGAGAGGTTTTCTAGGGCACATACT
GAGTGAGAGCAGTGTTGAGAAGTCGGGGAAAATGGTGACTACTTTTAGAGCAAGGCTGGGCATCAGCACCTGTCCAGCTCTACTTGTGTG
ATGTTTCAGGAACTCAGCCCCTTTTTCTGCCTAGGATAAGGAGCTGAAAGATTAACTTGGATCTTCTAATGGTCCAAATCTTTTGGTCAC
AATAAAGAGTCTCCAAATTAGAGACTGCATGTTAGTTCTGGATGGATTTGGTGGCCTGACATGATACCCTGCCAGCTGTGAGGGGACCCC
GTTTTTAAGATGCATGGCCAAGCTCTCTGCAAATGGAAATGCTTACACTGGGTGTTGGGGATGTTTGCTACCTCCTGCTATTTTTGTGGT
TTTGGTTCTCCCACTATGGTAGGACCCCTGGCCAGCATTGTGGCTTGTCATGTCAGCCCCATTGACTACCTTCTCATGCTCTGAGGTACT
ACTGCCTCTGCAGCACAAATTTCTATTTCTGTCAATAAAAGGAGATGAAAATATTC

>59077_59077_6_NHLRC3-PAK1_NHLRC3_chr13_39613848_ENST00000379600_PAK1_chr11_77091039_ENST00000530617_length(amino acids)=646AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSANKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT
DKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALT
RNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN
IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP
EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDV
EKRGSAKELLQHSSRL

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Fusion Gene PPI Analysis for NHLRC3-PAK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePAK1chr13:39613848chr11:77091039ENST00000278568116132_27063.333333333333336554.0CRIPAK
TgenePAK1chr13:39613848chr11:77091039ENST00000356341115132_27063.333333333333336546.0CRIPAK


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NHLRC3-PAK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NHLRC3-PAK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4748428INTELLECTUAL DEVELOPMENTAL DISORDER WITH MACROCEPHALY, SEIZURES, AND SPEECH DELAY2GENOMICS_ENGLAND;UNIPROT
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0033687Proteinuria1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1535926Neurodevelopmental Disorders1GENOMICS_ENGLAND
TgeneC4704874Mammary Carcinoma, Human1CTD_human