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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C16orf87-ATXN2 (FusionGDB2 ID:HG388272TG6311)

Fusion Gene Summary for C16orf87-ATXN2

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf87-ATXN2
Fusion gene ID: hg388272tg6311
HgeneTgene
Gene symbol

C16orf87

ATXN2

Gene ID

388272

6311

Gene namechromosome 16 open reading frame 87ataxin 2
Synonyms-ATX2|SCA2|TNRC13
Cytomap('C16orf87')('ATXN2')

16q11.2

12q24.12

Type of geneprotein-codingprotein-coding
DescriptionUPF0547 protein C16orf87ataxin-2spinocerebellar ataxia type 2 proteintrinucleotide repeat-containing gene 13 protein
Modification date2020031320200313
UniProtAcc

Q6PH81

.
Ensembl transtripts involved in fusion geneENST00000285697, ENST00000394806, 
ENST00000564250, 
Fusion gene scores* DoF score4 X 3 X 4=4821 X 19 X 10=3990
# samples 527
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/3990*10)=-3.88535743405888
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C16orf87 [Title/Abstract] AND ATXN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC16orf87(46864996)-ATXN2(111891649), # samples:2
Anticipated loss of major functional domain due to fusion event.C16orf87-ATXN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C16orf87-ATXN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C16orf87 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATXN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A425-01AC16orf87chr16

46864996

-ATXN2chr12

111891649

-


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Fusion Gene ORF analysis for C16orf87-ATXN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000285697ENST00000535949C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000285697ENST00000542287C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000285697ENST00000550104C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000394806ENST00000535949C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000394806ENST00000542287C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000394806ENST00000550104C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-intronENST00000285697ENST00000549455C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-intronENST00000394806ENST00000549455C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000285697ENST00000377617C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000285697ENST00000389153C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000285697ENST00000608853C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000394806ENST00000377617C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000394806ENST00000389153C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000394806ENST00000608853C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3CDSENST00000564250ENST00000377617C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3CDSENST00000564250ENST00000389153C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3CDSENST00000564250ENST00000608853C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3UTRENST00000564250ENST00000535949C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3UTRENST00000564250ENST00000542287C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3UTRENST00000564250ENST00000550104C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-intronENST00000564250ENST00000549455C16orf87chr16

46864996

-ATXN2chr12

111891649

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000394806C16orf87chr1646864996-ENST00000389153ATXN2chr12111891649-8757957392111
ENST00000394806C16orf87chr1646864996-ENST00000608853ATXN2chr12111891649-8757957392111
ENST00000394806C16orf87chr1646864996-ENST00000377617ATXN2chr12111891649-8757957392111
ENST00000285697C16orf87chr1646864996-ENST00000389153ATXN2chr12111891649-11243285532184
ENST00000285697C16orf87chr1646864996-ENST00000608853ATXN2chr12111891649-11243285532184
ENST00000285697C16orf87chr1646864996-ENST00000377617ATXN2chr12111891649-11243285532184

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394806ENST00000389153C16orf87chr1646864996-ATXN2chr12111891649-0.25194060.7480594
ENST00000394806ENST00000608853C16orf87chr1646864996-ATXN2chr12111891649-0.25194060.7480594
ENST00000394806ENST00000377617C16orf87chr1646864996-ATXN2chr12111891649-0.25194060.7480594
ENST00000285697ENST00000389153C16orf87chr1646864996-ATXN2chr12111891649-0.396886560.6031134
ENST00000285697ENST00000608853C16orf87chr1646864996-ATXN2chr12111891649-0.396886560.6031134
ENST00000285697ENST00000377617C16orf87chr1646864996-ATXN2chr12111891649-0.396886560.6031134

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Fusion Genomic Features for C16orf87-ATXN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C16orf87-ATXN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:46864996/chr12:111891649)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C16orf87

Q6PH81

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC16orf87chr16:46864996chr12:111891649ENST00000285697-14104_13222155.0Coiled coilOntology_term=ECO:0000255
HgeneC16orf87chr16:46864996chr12:111891649ENST00000394806-13104_1322294.0Coiled coilOntology_term=ECO:0000255
TgeneATXN2chr16:46864996chr12:111891649ENST000003776172225166_18712481314.0Compositional biasNote=Poly-Gln
TgeneATXN2chr16:46864996chr12:111891649ENST000003776172225213_22312481314.0Compositional biasNote=Poly-Ser
TgeneATXN2chr16:46864996chr12:111891649ENST00000377617222547_15812481314.0Compositional biasNote=Pro-rich
TgeneATXN2chr16:46864996chr12:111891649ENST000003776172225551_73412481314.0Compositional biasNote=Pro-rich
TgeneATXN2chr16:46864996chr12:111891649ENST00000377617222555_6412481314.0Compositional biasNote=Poly-Pro
TgeneATXN2chr16:46864996chr12:111891649ENST000003776172225929_108512481314.0Compositional biasNote=Pro-rich
TgeneATXN2chr16:46864996chr12:111891649ENST000005501042124166_18712271015.3333333333334Compositional biasNote=Poly-Gln
TgeneATXN2chr16:46864996chr12:111891649ENST000005501042124213_22312271015.3333333333334Compositional biasNote=Poly-Ser
TgeneATXN2chr16:46864996chr12:111891649ENST00000550104212447_15812271015.3333333333334Compositional biasNote=Pro-rich
TgeneATXN2chr16:46864996chr12:111891649ENST000005501042124551_73412271015.3333333333334Compositional biasNote=Pro-rich
TgeneATXN2chr16:46864996chr12:111891649ENST00000550104212455_6412271015.3333333333334Compositional biasNote=Poly-Pro
TgeneATXN2chr16:46864996chr12:111891649ENST000005501042124929_108512271015.3333333333334Compositional biasNote=Pro-rich


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Fusion Gene Sequence for C16orf87-ATXN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11042_11042_1_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000285697_ATXN2_chr12_111891649_ENST00000377617_length(transcript)=1124nt_BP=328nt
GATACTCTGGGCGAGCTCGCGGGCGGGCTGTGGGTCGCGAGCCGCCGTGGGAGCGCGTGTCGCGGTCCCCAGGAGCCGCCGGCCGACGCT
CCGCCCCGCCCCCTTGGCGCCCAGGTCCCGCGCGAGCTCGCGCACGCGCGCGCGCGCACCCGCCAGAGGCTTGTTTGAGGCCCGCGGGGA
CTGGGCGGGCGGAGGCCGGGCTGCCGAAGTGTGAGGGGAGGAGCCCGAGCCGTCGCTGCTGCCGCCGCTAAGGGAGAGGAGCATGTCTGC
AACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTTCCTTCTCA
TCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTACAGCCCAT
TCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCAGTTGTAAGGCTGCCCTGGAGG
AACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATTTCATTTATTTTGTTTTTAAAA
TATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGGACCGAGTAGAGGCATTTAGGA
ACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCGAAACTGGAAGTTATTTATTTT
TTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTATTACTGCTAAAAAAAAAAAAA
AAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAAACTGACGGATTATTATTTATA
AATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACTTTGTAGATAATATAAAATAAA

>11042_11042_1_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000285697_ATXN2_chr12_111891649_ENST00000377617_length(amino acids)=184AA_BP=1
MAFRFLQGSLTTAVGGGLVLKGASYRGNALLSRLEWAVVHFERGRPGDRRVAVSSLASLAHGQLDEKEPFLTVHEPVGRTRGMIWWPSSL
SWLELQTCSSPLAAAAATARAPPLTLRQPGLRPPSPRGPQTSLWRVRARACASSRGTWAPRGRGGASAGGSWGPRHALPRRLATHSPPAS

--------------------------------------------------------------
>11042_11042_2_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000285697_ATXN2_chr12_111891649_ENST00000389153_length(transcript)=1124nt_BP=328nt
GATACTCTGGGCGAGCTCGCGGGCGGGCTGTGGGTCGCGAGCCGCCGTGGGAGCGCGTGTCGCGGTCCCCAGGAGCCGCCGGCCGACGCT
CCGCCCCGCCCCCTTGGCGCCCAGGTCCCGCGCGAGCTCGCGCACGCGCGCGCGCGCACCCGCCAGAGGCTTGTTTGAGGCCCGCGGGGA
CTGGGCGGGCGGAGGCCGGGCTGCCGAAGTGTGAGGGGAGGAGCCCGAGCCGTCGCTGCTGCCGCCGCTAAGGGAGAGGAGCATGTCTGC
AACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTTCCTTCTCA
TCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTACAGCCCAT
TCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCAGTTGTAAGGCTGCCCTGGAGG
AACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATTTCATTTATTTTGTTTTTAAAA
TATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGGACCGAGTAGAGGCATTTAGGA
ACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCGAAACTGGAAGTTATTTATTTT
TTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTATTACTGCTAAAAAAAAAAAAA
AAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAAACTGACGGATTATTATTTATA
AATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACTTTGTAGATAATATAAAATAAA

>11042_11042_2_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000285697_ATXN2_chr12_111891649_ENST00000389153_length(amino acids)=184AA_BP=1
MAFRFLQGSLTTAVGGGLVLKGASYRGNALLSRLEWAVVHFERGRPGDRRVAVSSLASLAHGQLDEKEPFLTVHEPVGRTRGMIWWPSSL
SWLELQTCSSPLAAAAATARAPPLTLRQPGLRPPSPRGPQTSLWRVRARACASSRGTWAPRGRGGASAGGSWGPRHALPRRLATHSPPAS

--------------------------------------------------------------
>11042_11042_3_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000285697_ATXN2_chr12_111891649_ENST00000608853_length(transcript)=1124nt_BP=328nt
GATACTCTGGGCGAGCTCGCGGGCGGGCTGTGGGTCGCGAGCCGCCGTGGGAGCGCGTGTCGCGGTCCCCAGGAGCCGCCGGCCGACGCT
CCGCCCCGCCCCCTTGGCGCCCAGGTCCCGCGCGAGCTCGCGCACGCGCGCGCGCGCACCCGCCAGAGGCTTGTTTGAGGCCCGCGGGGA
CTGGGCGGGCGGAGGCCGGGCTGCCGAAGTGTGAGGGGAGGAGCCCGAGCCGTCGCTGCTGCCGCCGCTAAGGGAGAGGAGCATGTCTGC
AACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTTCCTTCTCA
TCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTACAGCCCAT
TCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCAGTTGTAAGGCTGCCCTGGAGG
AACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATTTCATTTATTTTGTTTTTAAAA
TATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGGACCGAGTAGAGGCATTTAGGA
ACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCGAAACTGGAAGTTATTTATTTT
TTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTATTACTGCTAAAAAAAAAAAAA
AAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAAACTGACGGATTATTATTTATA
AATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACTTTGTAGATAATATAAAATAAA

>11042_11042_3_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000285697_ATXN2_chr12_111891649_ENST00000608853_length(amino acids)=184AA_BP=1
MAFRFLQGSLTTAVGGGLVLKGASYRGNALLSRLEWAVVHFERGRPGDRRVAVSSLASLAHGQLDEKEPFLTVHEPVGRTRGMIWWPSSL
SWLELQTCSSPLAAAAATARAPPLTLRQPGLRPPSPRGPQTSLWRVRARACASSRGTWAPRGRGGASAGGSWGPRHALPRRLATHSPPAS

--------------------------------------------------------------
>11042_11042_4_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000394806_ATXN2_chr12_111891649_ENST00000377617_length(transcript)=875nt_BP=79nt
AAGGGAGAGGAGCATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACA
GTCAGGAATGGTTCCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGC
TCAAAGTGCACTACAGCCCATTCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCA
GTTGTAAGGCTGCCCTGGAGGAACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATT
TCATTTATTTTGTTTTTAAAATATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGG
ACCGAGTAGAGGCATTTAGGAACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCG
AAACTGGAAGTTATTTATTTTTTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTA
TTACTGCTAAAAAAAAAAAAAAAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAA
ACTGACGGATTATTATTTATAAATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACT

>11042_11042_4_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000394806_ATXN2_chr12_111891649_ENST00000377617_length(amino acids)=111AA_BP=7
MPRVRPTGSCTVRNGSFSSNCPCANDANDDTATRRSPGRPRSKCTTAHSSLDNSAFPLYDAPFSTSPPPTAVVRLPWRNRKAKFPPPFYC

--------------------------------------------------------------
>11042_11042_5_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000394806_ATXN2_chr12_111891649_ENST00000389153_length(transcript)=875nt_BP=79nt
AAGGGAGAGGAGCATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACA
GTCAGGAATGGTTCCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGC
TCAAAGTGCACTACAGCCCATTCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCA
GTTGTAAGGCTGCCCTGGAGGAACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATT
TCATTTATTTTGTTTTTAAAATATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGG
ACCGAGTAGAGGCATTTAGGAACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCG
AAACTGGAAGTTATTTATTTTTTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTA
TTACTGCTAAAAAAAAAAAAAAAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAA
ACTGACGGATTATTATTTATAAATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACT

>11042_11042_5_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000394806_ATXN2_chr12_111891649_ENST00000389153_length(amino acids)=111AA_BP=7
MPRVRPTGSCTVRNGSFSSNCPCANDANDDTATRRSPGRPRSKCTTAHSSLDNSAFPLYDAPFSTSPPPTAVVRLPWRNRKAKFPPPFYC

--------------------------------------------------------------
>11042_11042_6_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000394806_ATXN2_chr12_111891649_ENST00000608853_length(transcript)=875nt_BP=79nt
AAGGGAGAGGAGCATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACA
GTCAGGAATGGTTCCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGC
TCAAAGTGCACTACAGCCCATTCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCA
GTTGTAAGGCTGCCCTGGAGGAACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATT
TCATTTATTTTGTTTTTAAAATATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGG
ACCGAGTAGAGGCATTTAGGAACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCG
AAACTGGAAGTTATTTATTTTTTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTA
TTACTGCTAAAAAAAAAAAAAAAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAA
ACTGACGGATTATTATTTATAAATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACT

>11042_11042_6_C16orf87-ATXN2_C16orf87_chr16_46864996_ENST00000394806_ATXN2_chr12_111891649_ENST00000608853_length(amino acids)=111AA_BP=7
MPRVRPTGSCTVRNGSFSSNCPCANDANDDTATRRSPGRPRSKCTTAHSSLDNSAFPLYDAPFSTSPPPTAVVRLPWRNRKAKFPPPFYC

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Fusion Gene PPI Analysis for C16orf87-ATXN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C16orf87-ATXN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C16orf87-ATXN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0752121Spinocerebellar Ataxia Type 23CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
TgeneC0087012Ataxia, Spinocerebellar2CTD_human
TgeneC0752120Spinocerebellar Ataxia Type 12CTD_human
TgeneC0752122Spinocerebellar Ataxia Type 42CTD_human
TgeneC0752123Spinocerebellar Ataxia Type 52CTD_human
TgeneC0752124Spinocerebellar Ataxia Type 6 (disorder)2CTD_human
TgeneC0752125Spinocerebellar Ataxia Type 72CTD_human
TgeneC0017612Glaucoma, Open-Angle1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0271148Secondary Open Angle Glaucoma1CTD_human
TgeneC0339573Glaucoma, Primary Open Angle1CTD_human
TgeneC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human