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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM69A-ENSA (FusionGDB2 ID:HG388650TG2029)

Fusion Gene Summary for FAM69A-ENSA

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM69A-ENSA
Fusion gene ID: hg388650tg2029
HgeneTgene
Gene symbol

FAM69A

ENSA

Gene ID

388650

2029

Gene namedivergent protein kinase domain 1Aendosulfine alpha
SynonymsFAM69AARPP-19e
Cytomap('FAM69A')('ENSA')

1p22.1

1q21.3

Type of geneprotein-codingprotein-coding
Descriptiondivergent protein kinase domain 1Afamily with sequence similarity 69 member Aprotein FAM69Aalpha-endosulfine
Modification date2020031320200313
UniProtAcc.

O43768

Ensembl transtripts involved in fusion geneENST00000370310, 
Fusion gene scores* DoF score14 X 10 X 7=9805 X 4 X 2=40
# samples 156
** MAII scorelog2(15/980*10)=-2.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM69A [Title/Abstract] AND ENSA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM69A(93312739)-ENSA(150598284), # samples:1
FAM69A(93312740)-ENSA(150598284), # samples:1
Anticipated loss of major functional domain due to fusion event.FAM69A-ENSA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FAM69A-ENSA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneENSA

GO:0050796

regulation of insulin secretion

9653196


check buttonFusion gene breakpoints across FAM69A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ENSA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8284-01AFAM69Achr1

93312740

-ENSAchr1

150598284

-
ChimerDB4STADTCGA-BR-8284FAM69Achr1

93312739

-ENSAchr1

150598284

-


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Fusion Gene ORF analysis for FAM69A-ENSA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000370310ENST00000503241FAM69Achr1

93312740

-ENSAchr1

150598284

-
5CDS-3UTRENST00000370310ENST00000503241FAM69Achr1

93312739

-ENSAchr1

150598284

-
5CDS-3UTRENST00000370310ENST00000503345FAM69Achr1

93312740

-ENSAchr1

150598284

-
5CDS-3UTRENST00000370310ENST00000503345FAM69Achr1

93312739

-ENSAchr1

150598284

-
5CDS-5UTRENST00000370310ENST00000354702FAM69Achr1

93312740

-ENSAchr1

150598284

-
5CDS-5UTRENST00000370310ENST00000354702FAM69Achr1

93312739

-ENSAchr1

150598284

-
5CDS-intronENST00000370310ENST00000361532FAM69Achr1

93312740

-ENSAchr1

150598284

-
5CDS-intronENST00000370310ENST00000361532FAM69Achr1

93312739

-ENSAchr1

150598284

-
5CDS-intronENST00000370310ENST00000361631FAM69Achr1

93312740

-ENSAchr1

150598284

-
5CDS-intronENST00000370310ENST00000361631FAM69Achr1

93312739

-ENSAchr1

150598284

-
5CDS-intronENST00000370310ENST00000362052FAM69Achr1

93312740

-ENSAchr1

150598284

-
5CDS-intronENST00000370310ENST00000362052FAM69Achr1

93312739

-ENSAchr1

150598284

-
5CDS-intronENST00000370310ENST00000513281FAM69Achr1

93312740

-ENSAchr1

150598284

-
5CDS-intronENST00000370310ENST00000513281FAM69Achr1

93312739

-ENSAchr1

150598284

-
Frame-shiftENST00000370310ENST00000271690FAM69Achr1

93312740

-ENSAchr1

150598284

-
Frame-shiftENST00000370310ENST00000271690FAM69Achr1

93312739

-ENSAchr1

150598284

-
Frame-shiftENST00000370310ENST00000356527FAM69Achr1

93312740

-ENSAchr1

150598284

-
Frame-shiftENST00000370310ENST00000356527FAM69Achr1

93312739

-ENSAchr1

150598284

-
In-frameENST00000370310ENST00000339643FAM69Achr1

93312740

-ENSAchr1

150598284

-
In-frameENST00000370310ENST00000339643FAM69Achr1

93312739

-ENSAchr1

150598284

-
In-frameENST00000370310ENST00000369009FAM69Achr1

93312740

-ENSAchr1

150598284

-
In-frameENST00000370310ENST00000369009FAM69Achr1

93312739

-ENSAchr1

150598284

-
In-frameENST00000370310ENST00000369014FAM69Achr1

93312740

-ENSAchr1

150598284

-
In-frameENST00000370310ENST00000369014FAM69Achr1

93312739

-ENSAchr1

150598284

-
In-frameENST00000370310ENST00000369016FAM69Achr1

93312740

-ENSAchr1

150598284

-
In-frameENST00000370310ENST00000369016FAM69Achr1

93312739

-ENSAchr1

150598284

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370310FAM69Achr193312739-ENST00000369016ENSAchr1150598284-114154571877268
ENST00000370310FAM69Achr193312739-ENST00000369014ENSAchr1150598284-232154571727218
ENST00000370310FAM69Achr193312739-ENST00000369009ENSAchr1150598284-144454571727218
ENST00000370310FAM69Achr193312739-ENST00000339643ENSAchr1150598284-84154571727218
ENST00000370310FAM69Achr193312740-ENST00000369016ENSAchr1150598284-114154571877268
ENST00000370310FAM69Achr193312740-ENST00000369014ENSAchr1150598284-232154571727218
ENST00000370310FAM69Achr193312740-ENST00000369009ENSAchr1150598284-144454571727218
ENST00000370310FAM69Achr193312740-ENST00000339643ENSAchr1150598284-84154571727218

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370310ENST00000369016FAM69Achr193312739-ENSAchr1150598284-0.0028450450.99715495
ENST00000370310ENST00000369014FAM69Achr193312739-ENSAchr1150598284-0.0008756970.99912435
ENST00000370310ENST00000369009FAM69Achr193312739-ENSAchr1150598284-0.0009899730.99900997
ENST00000370310ENST00000339643FAM69Achr193312739-ENSAchr1150598284-0.0015251230.9984749
ENST00000370310ENST00000369016FAM69Achr193312740-ENSAchr1150598284-0.0028450450.99715495
ENST00000370310ENST00000369014FAM69Achr193312740-ENSAchr1150598284-0.0008756970.99912435
ENST00000370310ENST00000369009FAM69Achr193312740-ENSAchr1150598284-0.0009899730.99900997
ENST00000370310ENST00000339643FAM69Achr193312740-ENSAchr1150598284-0.0015251230.9984749

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Fusion Genomic Features for FAM69A-ENSA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FAM69A-ENSA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:93312739/chr1:150598284)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ENSA

O43768

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM69Achr1:93312739chr1:150598284ENST00000370310-451_27158429.0Topological domainCytoplasmic
HgeneFAM69Achr1:93312740chr1:150598284ENST00000370310-451_27158429.0Topological domainCytoplasmic
HgeneFAM69Achr1:93312739chr1:150598284ENST00000370310-4528_48158429.0TransmembraneHelical
HgeneFAM69Achr1:93312740chr1:150598284ENST00000370310-4528_48158429.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM69Achr1:93312739chr1:150598284ENST00000370310-4549_428158429.0Topological domainLumenal
HgeneFAM69Achr1:93312740chr1:150598284ENST00000370310-4549_428158429.0Topological domainLumenal


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Fusion Gene Sequence for FAM69A-ENSA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29165_29165_1_FAM69A-ENSA_FAM69A_chr1_93312739_ENST00000370310_ENSA_chr1_150598284_ENST00000339643_length(transcript)=841nt_BP=545nt
GGCGGGGAGCCCGGCCGCCAGCGCTCGGGTCCGCCTCTGACTGCAGCGCGGCGGGGCGATGTGTGATTACCATGGCGAGGAGTCTCTGTC
CGGGGGCCTGGCTAAGGAAACCCTATTACCTCCAGGCTCGCTTCTCATATGTGCGGATGAAATATCTTTTCTTTTCCTGGTTAGTGGTTT
TTGTTGGAAGCTGGATTATATATGTGCAGTATTCTACCTATACAGAATTATGCAGAGGAAAGGACTGTAAGAAAATAATATGTGACAAGT
ACAAGACTGGAGTTATTGATGGGCCTGCATGTAACAGCCTTTGTGTTACAGAAACTCTTTACTTTGGAAAATGTTTATCCACCAAGCCCA
ACAATCAGATGTATTTAGGGATTTGGGATAATCTACCAGGTGTTGTGAAATGTCAAATGGAACAAGCGCTTCATCTTGATTTTGGAACTG
AATTGGAACCAAGAAAAGAAATAGTGCTATTTGATAAGCCAACTAGAGGAACTACTGTACAAAAATTTAAAGAAATGGTCTATAGTCTCT
TTAAGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGA
ACCTGGTGACTGGTGATCACATCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGGGTGGCCAAG
TTGAATGATGCTGCCCGGGGCTCTGCCAGATCCTGAGACGCTTCCCCTCCCTGCCCCACCCGGGTCCTGTGCTGGCTCCTGCCCCTTCCT
GCTTTTGCAGCCAGGGGTCAGGAGGTGGCTC

>29165_29165_1_FAM69A-ENSA_FAM69A_chr1_93312739_ENST00000370310_ENSA_chr1_150598284_ENST00000339643_length(amino acids)=218AA_BP=158
MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGK
CLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKQKYFDSGDYNMAKAKMKNKQLP
SAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE

--------------------------------------------------------------
>29165_29165_2_FAM69A-ENSA_FAM69A_chr1_93312739_ENST00000370310_ENSA_chr1_150598284_ENST00000369009_length(transcript)=1444nt_BP=545nt
GGCGGGGAGCCCGGCCGCCAGCGCTCGGGTCCGCCTCTGACTGCAGCGCGGCGGGGCGATGTGTGATTACCATGGCGAGGAGTCTCTGTC
CGGGGGCCTGGCTAAGGAAACCCTATTACCTCCAGGCTCGCTTCTCATATGTGCGGATGAAATATCTTTTCTTTTCCTGGTTAGTGGTTT
TTGTTGGAAGCTGGATTATATATGTGCAGTATTCTACCTATACAGAATTATGCAGAGGAAAGGACTGTAAGAAAATAATATGTGACAAGT
ACAAGACTGGAGTTATTGATGGGCCTGCATGTAACAGCCTTTGTGTTACAGAAACTCTTTACTTTGGAAAATGTTTATCCACCAAGCCCA
ACAATCAGATGTATTTAGGGATTTGGGATAATCTACCAGGTGTTGTGAAATGTCAAATGGAACAAGCGCTTCATCTTGATTTTGGAACTG
AATTGGAACCAAGAAAAGAAATAGTGCTATTTGATAAGCCAACTAGAGGAACTACTGTACAAAAATTTAAAGAAATGGTCTATAGTCTCT
TTAAGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGA
ACCTGGTGACTGGTGATCACATCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGGGTGGCCAAG
TTGAATGATGCTGCCCGGGGCTCTGCCAGATCCTGAGACGCTTCCCCTCCCTGCCCCACCCGGGTCCTGTGCTGGCTCCTGCCCCTTCCT
GCTTTTGCAGCCAGGGGTCAGGAGGTGGCTCGGGTGTGGGCTGGAGAGGCAGAAGCCCTTTCCTGTTGGTGTCCCAGCACATGGAGCCCC
TTGGGCTGAGCACCAAGACCTTGAACCTTTTTTGTTTTACCTTTTTTCCAAATAACAGTTGGGAGAAATATCAATGAAATTCTGGGGGTG
GGGGTGGGGTTGAAAGGGTGGGGTGGGAGATATGGAGGAGTATGAATTAGGGCTTGGAGTTGGTAAAAACATTCCTGACTATCCTTCTTA
ACCACGTGGCTGATGTGGGGTAGGTATGAGGGGAAGGAAGTGGAGTAGCCTAATGAAAAGGGGTTCTAGTTGAGCTCTGTAGATAAATGC
CTTGTTTCAGTGTGGTTGGAGACCTGGTGTCAGATAAAAGAAACTCCATCCGCACAGACAGATGCAAACAGCTCCTCTAGTTCTGCAGAG
CTAGTTGAGAACTCAACATTAATCATTTTAAAAAGTACTGTCCTTGAAATAGATTTGCTGTGGGAAGAAGGGCAGTGAGTGTGGGAGAAA
GGAGCCGTGAGCGTGGGGAACCCCACAGAGCCCAAAGGACTTTTTCAGTATTCGAAATAAACAAAACAAAAACCCATGAAAAAACCCAAC
CCAG

>29165_29165_2_FAM69A-ENSA_FAM69A_chr1_93312739_ENST00000370310_ENSA_chr1_150598284_ENST00000369009_length(amino acids)=218AA_BP=158
MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGK
CLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKQKYFDSGDYNMAKAKMKNKQLP
SAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE

--------------------------------------------------------------
>29165_29165_3_FAM69A-ENSA_FAM69A_chr1_93312739_ENST00000370310_ENSA_chr1_150598284_ENST00000369014_length(transcript)=2321nt_BP=545nt
GGCGGGGAGCCCGGCCGCCAGCGCTCGGGTCCGCCTCTGACTGCAGCGCGGCGGGGCGATGTGTGATTACCATGGCGAGGAGTCTCTGTC
CGGGGGCCTGGCTAAGGAAACCCTATTACCTCCAGGCTCGCTTCTCATATGTGCGGATGAAATATCTTTTCTTTTCCTGGTTAGTGGTTT
TTGTTGGAAGCTGGATTATATATGTGCAGTATTCTACCTATACAGAATTATGCAGAGGAAAGGACTGTAAGAAAATAATATGTGACAAGT
ACAAGACTGGAGTTATTGATGGGCCTGCATGTAACAGCCTTTGTGTTACAGAAACTCTTTACTTTGGAAAATGTTTATCCACCAAGCCCA
ACAATCAGATGTATTTAGGGATTTGGGATAATCTACCAGGTGTTGTGAAATGTCAAATGGAACAAGCGCTTCATCTTGATTTTGGAACTG
AATTGGAACCAAGAAAAGAAATAGTGCTATTTGATAAGCCAACTAGAGGAACTACTGTACAAAAATTTAAAGAAATGGTCTATAGTCTCT
TTAAGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGA
ACCTGGTGACTGGTGATCACATCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGGGTGGCCAAG
TTGAATGATGCTGCCCGGGGCTCTGCCAGATCCTGAGACGCTTCCCCTCCCTGCCCCACCCGGGTCCTGTGCTGGCTCCTGCCCCTTCCT
GCTTTTGCAGCCAGGGGTCAGGAGGTGGCTCGGGTGTGGGCTGGAGAGGCAGAAGCCCTTTCCTGTTGGTGTCCCAGCACATGGAGCCCC
TTGGGCTGAGCACCAAGACCTTGAACCTTTTTTGTTTTACCTTTTTTCCAAATAACAGTTGGGAGAAATATCAATGAAATTCTGGGGGTG
GGGGTGGGGTTGAAAGGGTGGGGTGGGAGATATGGAGGAGTATGAATTAGGGCTTGGAGTTGGTAAAAACATTCCTGACTATCCTTCTTA
ACCACGTGGCTGATGTGGGGTAGGTATGAGGGGAAGGAAGTGGAGTAGCCTAATGAAAAGGGGTTCTAGTTGAGCTCTGTAGATAAATGC
CTTGTTTCAGTGTGGTTGGAGACCTGGTGTCAGATAAAAGAAACTCCATCCGCACAGACAGATGCAAACAGCTCCTCTAGTTCTGCAGAG
CTAGTTGAGAACTCAACATTAATCATTTTAAAAAGTACTGTCCTTGAAATAGATTTGCTGTGGGAAGAAGGGCAGTGAGTGTGGGAGAAA
GGAGCCGTGAGCGTGGGGAACCCCACAGAGCCCAAAGGACTTTTTCAGTATTCGAAATAAACAAAACAAAAACCCATGAAAAAACCCAAC
CCAGAAATATTCTGAAGCAGTTGGTGTGTTTTATTGGGGTTTGGGAGGGGGAAGAAAACAATACTGAAGACATTGTTAATGTGAGATGCG
GCTGAGTTCCCCAATACCATCACTTAGGAAAGGGAGCAGGAATGTTGGCATAAACCTTGCCCATCCCTTTGTTTCTGTAACCAATGTAGA
AGGTGCATCAACCTCAGTTTGTGGCTCACAAAATGAGGCATTTAAGATATTTGATCTAAATGGTTTCTTGACACCTAAGCCTAGTCCAGG
TTTAGCAGAAAAGGAGGCCCAGTCTCCTTTTCCCTCTGTCTTCCATTCCTTTTCAAGTTCCCATGTTTGTGAGGGAGAAATGTGACAAAC
CAAAAGAAATATATTATTTCTTTGTAATAAGCCAAAAGAAACTCAAGTCTTTCTGCTGGTGGCCAGCAGGAGGCAGAGTGATTTCTTTCC
TCATGATGTGCCAATCTGCATTGCTGGAAACCTGCTACTGAAAGAAGTTAAAAGCTGCCTGTGAATGTAACGTACAAAAGAAAGGTTACC
AAAGGAGAAAAAACTCCAGCGGGTGTACGGTGGCTCACGCCTATAATTCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACTTGAGGTC
AGGAGTTTGAGACCAGCCTAGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGCGGCACATGCCTATA
ATCCCACTTACTTGGGAGGCTGAGGTAGGAGAATCGCTTGAACCCAGGAGGCAGAGTTTGCAGTGAGCCGAGATTGTGCCATTGCACTCC
AGCCTGGGCGACAGAGCGAGACTCCATCTAAAAAAAATAAATGAATAAAATAAAACAAGTACAAATTTAAA

>29165_29165_3_FAM69A-ENSA_FAM69A_chr1_93312739_ENST00000370310_ENSA_chr1_150598284_ENST00000369014_length(amino acids)=218AA_BP=158
MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGK
CLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKQKYFDSGDYNMAKAKMKNKQLP
SAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE

--------------------------------------------------------------
>29165_29165_4_FAM69A-ENSA_FAM69A_chr1_93312739_ENST00000370310_ENSA_chr1_150598284_ENST00000369016_length(transcript)=1141nt_BP=545nt
GGCGGGGAGCCCGGCCGCCAGCGCTCGGGTCCGCCTCTGACTGCAGCGCGGCGGGGCGATGTGTGATTACCATGGCGAGGAGTCTCTGTC
CGGGGGCCTGGCTAAGGAAACCCTATTACCTCCAGGCTCGCTTCTCATATGTGCGGATGAAATATCTTTTCTTTTCCTGGTTAGTGGTTT
TTGTTGGAAGCTGGATTATATATGTGCAGTATTCTACCTATACAGAATTATGCAGAGGAAAGGACTGTAAGAAAATAATATGTGACAAGT
ACAAGACTGGAGTTATTGATGGGCCTGCATGTAACAGCCTTTGTGTTACAGAAACTCTTTACTTTGGAAAATGTTTATCCACCAAGCCCA
ACAATCAGATGTATTTAGGGATTTGGGATAATCTACCAGGTGTTGTGAAATGTCAAATGGAACAAGCGCTTCATCTTGATTTTGGAACTG
AATTGGAACCAAGAAAAGAAATAGTGCTATTTGATAAGCCAACTAGAGGAACTACTGTACAAAAATTTAAAGAAATGGTCTATAGTCTCT
TTAAGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGA
ACCTGGTGACTGGTGATCACATCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGGGACAAAGTT
TTGCTCTTGTCGCCCAGGCTGGAGTGCAATGGCATGATCTCTGCTTACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCA
GCCTCCTGAGTAGCTGGGATTACAGGCATGCAACACCACGCCCGGCTAATTTTGTAATTTTTTTGTAGAGACGGGGTTTCATCACGTTAG
CCAGGCTGGTCTCAAACTCCTGACCTCAGGTAATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCTG
GCCTCTCTACGGTAAATATTGAAAGTTGCTGGGTCACAGGGTATGCACATTTAAATTTTTTTTTTCTTTTTAAAGGGACAGAGTCTTGCT
CTGTTGCCCAGGCTGGAGTACAGTGACGCAATCTTGGCTCAATGCAACCTCCGCCTCCCGG

>29165_29165_4_FAM69A-ENSA_FAM69A_chr1_93312739_ENST00000370310_ENSA_chr1_150598284_ENST00000369016_length(amino acids)=268AA_BP=158
MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGK
CLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKQKYFDSGDYNMAKAKMKNKQLP
SAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGQSFALVAQAGVQWHDLCLLQPLPPGFKRFSCLSLLSSWDYRHATPRPANFVIFL

--------------------------------------------------------------
>29165_29165_5_FAM69A-ENSA_FAM69A_chr1_93312740_ENST00000370310_ENSA_chr1_150598284_ENST00000339643_length(transcript)=841nt_BP=545nt
GGCGGGGAGCCCGGCCGCCAGCGCTCGGGTCCGCCTCTGACTGCAGCGCGGCGGGGCGATGTGTGATTACCATGGCGAGGAGTCTCTGTC
CGGGGGCCTGGCTAAGGAAACCCTATTACCTCCAGGCTCGCTTCTCATATGTGCGGATGAAATATCTTTTCTTTTCCTGGTTAGTGGTTT
TTGTTGGAAGCTGGATTATATATGTGCAGTATTCTACCTATACAGAATTATGCAGAGGAAAGGACTGTAAGAAAATAATATGTGACAAGT
ACAAGACTGGAGTTATTGATGGGCCTGCATGTAACAGCCTTTGTGTTACAGAAACTCTTTACTTTGGAAAATGTTTATCCACCAAGCCCA
ACAATCAGATGTATTTAGGGATTTGGGATAATCTACCAGGTGTTGTGAAATGTCAAATGGAACAAGCGCTTCATCTTGATTTTGGAACTG
AATTGGAACCAAGAAAAGAAATAGTGCTATTTGATAAGCCAACTAGAGGAACTACTGTACAAAAATTTAAAGAAATGGTCTATAGTCTCT
TTAAGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGA
ACCTGGTGACTGGTGATCACATCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGGGTGGCCAAG
TTGAATGATGCTGCCCGGGGCTCTGCCAGATCCTGAGACGCTTCCCCTCCCTGCCCCACCCGGGTCCTGTGCTGGCTCCTGCCCCTTCCT
GCTTTTGCAGCCAGGGGTCAGGAGGTGGCTC

>29165_29165_5_FAM69A-ENSA_FAM69A_chr1_93312740_ENST00000370310_ENSA_chr1_150598284_ENST00000339643_length(amino acids)=218AA_BP=158
MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGK
CLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKQKYFDSGDYNMAKAKMKNKQLP
SAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE

--------------------------------------------------------------
>29165_29165_6_FAM69A-ENSA_FAM69A_chr1_93312740_ENST00000370310_ENSA_chr1_150598284_ENST00000369009_length(transcript)=1444nt_BP=545nt
GGCGGGGAGCCCGGCCGCCAGCGCTCGGGTCCGCCTCTGACTGCAGCGCGGCGGGGCGATGTGTGATTACCATGGCGAGGAGTCTCTGTC
CGGGGGCCTGGCTAAGGAAACCCTATTACCTCCAGGCTCGCTTCTCATATGTGCGGATGAAATATCTTTTCTTTTCCTGGTTAGTGGTTT
TTGTTGGAAGCTGGATTATATATGTGCAGTATTCTACCTATACAGAATTATGCAGAGGAAAGGACTGTAAGAAAATAATATGTGACAAGT
ACAAGACTGGAGTTATTGATGGGCCTGCATGTAACAGCCTTTGTGTTACAGAAACTCTTTACTTTGGAAAATGTTTATCCACCAAGCCCA
ACAATCAGATGTATTTAGGGATTTGGGATAATCTACCAGGTGTTGTGAAATGTCAAATGGAACAAGCGCTTCATCTTGATTTTGGAACTG
AATTGGAACCAAGAAAAGAAATAGTGCTATTTGATAAGCCAACTAGAGGAACTACTGTACAAAAATTTAAAGAAATGGTCTATAGTCTCT
TTAAGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGA
ACCTGGTGACTGGTGATCACATCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGGGTGGCCAAG
TTGAATGATGCTGCCCGGGGCTCTGCCAGATCCTGAGACGCTTCCCCTCCCTGCCCCACCCGGGTCCTGTGCTGGCTCCTGCCCCTTCCT
GCTTTTGCAGCCAGGGGTCAGGAGGTGGCTCGGGTGTGGGCTGGAGAGGCAGAAGCCCTTTCCTGTTGGTGTCCCAGCACATGGAGCCCC
TTGGGCTGAGCACCAAGACCTTGAACCTTTTTTGTTTTACCTTTTTTCCAAATAACAGTTGGGAGAAATATCAATGAAATTCTGGGGGTG
GGGGTGGGGTTGAAAGGGTGGGGTGGGAGATATGGAGGAGTATGAATTAGGGCTTGGAGTTGGTAAAAACATTCCTGACTATCCTTCTTA
ACCACGTGGCTGATGTGGGGTAGGTATGAGGGGAAGGAAGTGGAGTAGCCTAATGAAAAGGGGTTCTAGTTGAGCTCTGTAGATAAATGC
CTTGTTTCAGTGTGGTTGGAGACCTGGTGTCAGATAAAAGAAACTCCATCCGCACAGACAGATGCAAACAGCTCCTCTAGTTCTGCAGAG
CTAGTTGAGAACTCAACATTAATCATTTTAAAAAGTACTGTCCTTGAAATAGATTTGCTGTGGGAAGAAGGGCAGTGAGTGTGGGAGAAA
GGAGCCGTGAGCGTGGGGAACCCCACAGAGCCCAAAGGACTTTTTCAGTATTCGAAATAAACAAAACAAAAACCCATGAAAAAACCCAAC
CCAG

>29165_29165_6_FAM69A-ENSA_FAM69A_chr1_93312740_ENST00000370310_ENSA_chr1_150598284_ENST00000369009_length(amino acids)=218AA_BP=158
MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGK
CLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKQKYFDSGDYNMAKAKMKNKQLP
SAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE

--------------------------------------------------------------
>29165_29165_7_FAM69A-ENSA_FAM69A_chr1_93312740_ENST00000370310_ENSA_chr1_150598284_ENST00000369014_length(transcript)=2321nt_BP=545nt
GGCGGGGAGCCCGGCCGCCAGCGCTCGGGTCCGCCTCTGACTGCAGCGCGGCGGGGCGATGTGTGATTACCATGGCGAGGAGTCTCTGTC
CGGGGGCCTGGCTAAGGAAACCCTATTACCTCCAGGCTCGCTTCTCATATGTGCGGATGAAATATCTTTTCTTTTCCTGGTTAGTGGTTT
TTGTTGGAAGCTGGATTATATATGTGCAGTATTCTACCTATACAGAATTATGCAGAGGAAAGGACTGTAAGAAAATAATATGTGACAAGT
ACAAGACTGGAGTTATTGATGGGCCTGCATGTAACAGCCTTTGTGTTACAGAAACTCTTTACTTTGGAAAATGTTTATCCACCAAGCCCA
ACAATCAGATGTATTTAGGGATTTGGGATAATCTACCAGGTGTTGTGAAATGTCAAATGGAACAAGCGCTTCATCTTGATTTTGGAACTG
AATTGGAACCAAGAAAAGAAATAGTGCTATTTGATAAGCCAACTAGAGGAACTACTGTACAAAAATTTAAAGAAATGGTCTATAGTCTCT
TTAAGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGA
ACCTGGTGACTGGTGATCACATCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGGGTGGCCAAG
TTGAATGATGCTGCCCGGGGCTCTGCCAGATCCTGAGACGCTTCCCCTCCCTGCCCCACCCGGGTCCTGTGCTGGCTCCTGCCCCTTCCT
GCTTTTGCAGCCAGGGGTCAGGAGGTGGCTCGGGTGTGGGCTGGAGAGGCAGAAGCCCTTTCCTGTTGGTGTCCCAGCACATGGAGCCCC
TTGGGCTGAGCACCAAGACCTTGAACCTTTTTTGTTTTACCTTTTTTCCAAATAACAGTTGGGAGAAATATCAATGAAATTCTGGGGGTG
GGGGTGGGGTTGAAAGGGTGGGGTGGGAGATATGGAGGAGTATGAATTAGGGCTTGGAGTTGGTAAAAACATTCCTGACTATCCTTCTTA
ACCACGTGGCTGATGTGGGGTAGGTATGAGGGGAAGGAAGTGGAGTAGCCTAATGAAAAGGGGTTCTAGTTGAGCTCTGTAGATAAATGC
CTTGTTTCAGTGTGGTTGGAGACCTGGTGTCAGATAAAAGAAACTCCATCCGCACAGACAGATGCAAACAGCTCCTCTAGTTCTGCAGAG
CTAGTTGAGAACTCAACATTAATCATTTTAAAAAGTACTGTCCTTGAAATAGATTTGCTGTGGGAAGAAGGGCAGTGAGTGTGGGAGAAA
GGAGCCGTGAGCGTGGGGAACCCCACAGAGCCCAAAGGACTTTTTCAGTATTCGAAATAAACAAAACAAAAACCCATGAAAAAACCCAAC
CCAGAAATATTCTGAAGCAGTTGGTGTGTTTTATTGGGGTTTGGGAGGGGGAAGAAAACAATACTGAAGACATTGTTAATGTGAGATGCG
GCTGAGTTCCCCAATACCATCACTTAGGAAAGGGAGCAGGAATGTTGGCATAAACCTTGCCCATCCCTTTGTTTCTGTAACCAATGTAGA
AGGTGCATCAACCTCAGTTTGTGGCTCACAAAATGAGGCATTTAAGATATTTGATCTAAATGGTTTCTTGACACCTAAGCCTAGTCCAGG
TTTAGCAGAAAAGGAGGCCCAGTCTCCTTTTCCCTCTGTCTTCCATTCCTTTTCAAGTTCCCATGTTTGTGAGGGAGAAATGTGACAAAC
CAAAAGAAATATATTATTTCTTTGTAATAAGCCAAAAGAAACTCAAGTCTTTCTGCTGGTGGCCAGCAGGAGGCAGAGTGATTTCTTTCC
TCATGATGTGCCAATCTGCATTGCTGGAAACCTGCTACTGAAAGAAGTTAAAAGCTGCCTGTGAATGTAACGTACAAAAGAAAGGTTACC
AAAGGAGAAAAAACTCCAGCGGGTGTACGGTGGCTCACGCCTATAATTCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACTTGAGGTC
AGGAGTTTGAGACCAGCCTAGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGCGGCACATGCCTATA
ATCCCACTTACTTGGGAGGCTGAGGTAGGAGAATCGCTTGAACCCAGGAGGCAGAGTTTGCAGTGAGCCGAGATTGTGCCATTGCACTCC
AGCCTGGGCGACAGAGCGAGACTCCATCTAAAAAAAATAAATGAATAAAATAAAACAAGTACAAATTTAAA

>29165_29165_7_FAM69A-ENSA_FAM69A_chr1_93312740_ENST00000370310_ENSA_chr1_150598284_ENST00000369014_length(amino acids)=218AA_BP=158
MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGK
CLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKQKYFDSGDYNMAKAKMKNKQLP
SAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE

--------------------------------------------------------------
>29165_29165_8_FAM69A-ENSA_FAM69A_chr1_93312740_ENST00000370310_ENSA_chr1_150598284_ENST00000369016_length(transcript)=1141nt_BP=545nt
GGCGGGGAGCCCGGCCGCCAGCGCTCGGGTCCGCCTCTGACTGCAGCGCGGCGGGGCGATGTGTGATTACCATGGCGAGGAGTCTCTGTC
CGGGGGCCTGGCTAAGGAAACCCTATTACCTCCAGGCTCGCTTCTCATATGTGCGGATGAAATATCTTTTCTTTTCCTGGTTAGTGGTTT
TTGTTGGAAGCTGGATTATATATGTGCAGTATTCTACCTATACAGAATTATGCAGAGGAAAGGACTGTAAGAAAATAATATGTGACAAGT
ACAAGACTGGAGTTATTGATGGGCCTGCATGTAACAGCCTTTGTGTTACAGAAACTCTTTACTTTGGAAAATGTTTATCCACCAAGCCCA
ACAATCAGATGTATTTAGGGATTTGGGATAATCTACCAGGTGTTGTGAAATGTCAAATGGAACAAGCGCTTCATCTTGATTTTGGAACTG
AATTGGAACCAAGAAAAGAAATAGTGCTATTTGATAAGCCAACTAGAGGAACTACTGTACAAAAATTTAAAGAAATGGTCTATAGTCTCT
TTAAGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGA
ACCTGGTGACTGGTGATCACATCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGGGACAAAGTT
TTGCTCTTGTCGCCCAGGCTGGAGTGCAATGGCATGATCTCTGCTTACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCA
GCCTCCTGAGTAGCTGGGATTACAGGCATGCAACACCACGCCCGGCTAATTTTGTAATTTTTTTGTAGAGACGGGGTTTCATCACGTTAG
CCAGGCTGGTCTCAAACTCCTGACCTCAGGTAATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCTG
GCCTCTCTACGGTAAATATTGAAAGTTGCTGGGTCACAGGGTATGCACATTTAAATTTTTTTTTTCTTTTTAAAGGGACAGAGTCTTGCT
CTGTTGCCCAGGCTGGAGTACAGTGACGCAATCTTGGCTCAATGCAACCTCCGCCTCCCGG

>29165_29165_8_FAM69A-ENSA_FAM69A_chr1_93312740_ENST00000370310_ENSA_chr1_150598284_ENST00000369016_length(amino acids)=268AA_BP=158
MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGK
CLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKQKYFDSGDYNMAKAKMKNKQLP
SAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGQSFALVAQAGVQWHDLCLLQPLPPGFKRFSCLSLLSSWDYRHATPRPANFVIFL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM69A-ENSA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM69A-ENSA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM69A-ENSA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0151744Myocardial Ischemia1CTD_human