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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:C12orf76-GPX2 (FusionGDB2 ID:HG400073TG2877) |
Fusion Gene Summary for C12orf76-GPX2 |
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Fusion gene information | Fusion gene name: C12orf76-GPX2 | Fusion gene ID: hg400073tg2877 | Hgene | Tgene | Gene symbol | C12orf76 | GPX2 | Gene ID | 400073 | 2877 |
Gene name | chromosome 12 open reading frame 76 | glutathione peroxidase 2 | |
Synonyms | - | GI-GPx|GPRP|GPRP-2|GPx-2|GPx-GI|GSHPX-GI|GSHPx-2 | |
Cytomap | ('C12orf76')('GPX2') 12q24.11 | 14q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | uncharacterized protein C12orf76 | glutathione peroxidase 2gastrointestinal glutathione peroxidaseglutathione peroxidase 2 (gastrointestinal)glutathione peroxidase-related protein 2 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | Q8N812 | P18283 | |
Ensembl transtripts involved in fusion gene | ENST00000546627, ENST00000546651, ENST00000547573, ENST00000551185, ENST00000549724, ENST00000309050, ENST00000548191, ENST00000548936, | ||
Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 2 X 1 X 1=2 |
# samples | 5 | 2 | |
** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/2*10)=3.32192809488736 | |
Context | PubMed: C12orf76 [Title/Abstract] AND GPX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | C12orf76(110486168)-GPX2(65406556), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | C12orf76-GPX2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-8364-01A | C12orf76 | chr12 | 110486168 | - | GPX2 | chr14 | 65406556 | - |
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Fusion Gene ORF analysis for C12orf76-GPX2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000546627 | ENST00000389614 | C12orf76 | chr12 | 110486168 | - | GPX2 | chr14 | 65406556 | - |
Frame-shift | ENST00000546651 | ENST00000389614 | C12orf76 | chr12 | 110486168 | - | GPX2 | chr14 | 65406556 | - |
Frame-shift | ENST00000547573 | ENST00000389614 | C12orf76 | chr12 | 110486168 | - | GPX2 | chr14 | 65406556 | - |
Frame-shift | ENST00000551185 | ENST00000389614 | C12orf76 | chr12 | 110486168 | - | GPX2 | chr14 | 65406556 | - |
In-frame | ENST00000549724 | ENST00000389614 | C12orf76 | chr12 | 110486168 | - | GPX2 | chr14 | 65406556 | - |
intron-3CDS | ENST00000309050 | ENST00000389614 | C12orf76 | chr12 | 110486168 | - | GPX2 | chr14 | 65406556 | - |
intron-3CDS | ENST00000548191 | ENST00000389614 | C12orf76 | chr12 | 110486168 | - | GPX2 | chr14 | 65406556 | - |
intron-3CDS | ENST00000548936 | ENST00000389614 | C12orf76 | chr12 | 110486168 | - | GPX2 | chr14 | 65406556 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000549724 | C12orf76 | chr12 | 110486168 | - | ENST00000389614 | GPX2 | chr14 | 65406556 | - | 1418 | 737 | 581 | 1087 | 168 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000549724 | ENST00000389614 | C12orf76 | chr12 | 110486168 | - | GPX2 | chr14 | 65406556 | - | 0.41925973 | 0.58074033 |
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Fusion Genomic Features for C12orf76-GPX2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for C12orf76-GPX2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:110486168/chr14:65406556) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
C12orf76 | GPX2 |
FUNCTION: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for C12orf76-GPX2 |
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>10895_10895_1_C12orf76-GPX2_C12orf76_chr12_110486168_ENST00000549724_GPX2_chr14_65406556_ENST00000389614_length(transcript)=1418nt_BP=737nt AGGCAGGCCCAGGCCTGGTTTCGGGCCTGGCGCCGGGCTGCCCGTCTTTGGTTTCACTTCCTTGTTGTTTCTTCTTAAAACAGGTACTGA GTATAAAACAATATAAAACAAAATGAGAGGGTCTCTCTCTCCCCCAGTCTCTGGGACAGAGCAGAGAGCAAGAACAAAATCGCTGTGCTC GTGGACTTTACATGCTAGGGCGGAGCAGGTCCTCAGAAAATCATCAAATGCCCGTAATGAAGGTTTAATAAGAAAATGCATGGATTCGTA AAAAATCTTCAATAGGCCCCAAATGGACCTACAAGACCTCGACCCCAATGGATGAGGGAACGCTAACCACAGCAGAACGGTAATCGCGGC GAACGTTGGCACAGACGGAAAGTTGATCTGAACGGAAAGTTGGTCCGGGGGAAACATTAGTTATTGAGGAACGTTAATCCGGAACAAATC TTAGGCAGAAGCGGAACTTAGACCAGGACGCACAGTTACCATGGCAATGACGCGCGCCCTAAGGGCGGTGGCAGCGACGCAGAGAGACCT GGGAGGAGACAGAGGCAGGGCTTGCGACGGAAGTGGCCTCTCTGCTTCTGCAGGGCTGGGGAAGATGCTGCGTCCAGCGTTACCGTGGCT GTACCTTGGCCTCTGCAGCCTCCTGGTGGGGGAGGCAGAGGCCCCGAGCCCCGTGGATCCGCTGGAGCGGAGCCGGCCGTACGCGGTGCT GCGAGGGCAGAACCTGGGAGAACTGTCAGAATGAGGAGATCCTGAACAGTCTCAAGTATGTCCGTCCTGGGGGTGGATACCAGCCCACCT TCACCCTTGTCCAAAAATGTGAGGTGAATGGGCAGAACGAGCATCCTGTCTTCGCCTACCTGAAGGACAAGCTCCCCTACCCTTATGATG ACCCATTTTCCCTCATGACCGATCCCAAGCTCATCATTTGGAGCCCTGTGCGCCGCTCAGATGTGGCCTGGAACTTTGAGAAGTTCCTCA TAGGGCCGGAGGGAGAGCCCTTCCGACGCTACAGCCGCACCTTCCCAACCATCAACATTGAGCCTGACATCAAGCGCCTCCTTAAAGTTG CCATATAGATGTGAACTGCTCAACACACAGATCTCCTACTCCATCCAGTCCTGAGGAGCCTTAGGATGCAGCATGCCTTCAGGAGACACT GCTGGACCTCAGCATTCCCTTGATATCAGTCCCCTTCACTGCAGAGCCTTGCCTTTCCCCTCTGCCTGTTTCCTTTTCCTCTCCCAACCC TCTGGTTGGTGATTCAACTTGGGCTCCAAGACTTGGGTAAGCTCTGGGCCTTCACAGAATGATGGCACCTTCCTAAACCCTCATGGGTGG >10895_10895_1_C12orf76-GPX2_C12orf76_chr12_110486168_ENST00000549724_GPX2_chr14_65406556_ENST00000389614_length(amino acids)=168AA_BP=52 MLLQGWGRCCVQRYRGCTLASAASWWGRQRPRAPWIRWSGAGRTRCCEGRTWENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for C12orf76-GPX2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for C12orf76-GPX2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | GPX2 | P18283 | DB00143 | Glutathione | Cofactor | Small molecule | Approved|Investigational|Nutraceutical |
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Related Diseases for C12orf76-GPX2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0023903 | Liver neoplasms | 1 | CTD_human | |
Tgene | C0027627 | Neoplasm Metastasis | 1 | CTD_human | |
Tgene | C0345904 | Malignant neoplasm of liver | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |