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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD36C-FAM178B (FusionGDB2 ID:HG400986TG51252)

Fusion Gene Summary for ANKRD36C-FAM178B

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD36C-FAM178B
Fusion gene ID: hg400986tg51252
HgeneTgene
Gene symbol

ANKRD36C

FAM178B

Gene ID

400986

51252

Gene nameankyrin repeat domain 36Cfamily with sequence similarity 178 member B
Synonyms--
Cytomap('ANKRD36C')('FAM178B')

2q11.1

2q11.2

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 36Cprotein immuno-reactive with anti-PTH polyclonal antibodiesprotein FAM178B
Modification date2020031320200320
UniProtAcc

Q5JPF3

.
Ensembl transtripts involved in fusion geneENST00000456556, ENST00000295246, 
ENST00000419039, ENST00000420871, 
Fusion gene scores* DoF score2 X 2 X 2=812 X 9 X 8=864
# samples 219
** MAII scorelog2(2/8*10)=1.32192809488736log2(19/864*10)=-2.18503189383252
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD36C [Title/Abstract] AND FAM178B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD36C(96614278)-FAM178B(97559788), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANKRD36C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FAM178B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XJ-A9DXANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-


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Fusion Gene ORF analysis for ANKRD36C-FAM178B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000456556ENST00000393526ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
5CDS-5UTRENST00000456556ENST00000470789ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
In-frameENST00000456556ENST00000327896ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
In-frameENST00000456556ENST00000417561ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
In-frameENST00000456556ENST00000490605ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-3CDSENST00000295246ENST00000327896ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-3CDSENST00000295246ENST00000417561ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-3CDSENST00000295246ENST00000490605ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-3CDSENST00000419039ENST00000327896ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-3CDSENST00000419039ENST00000417561ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-3CDSENST00000419039ENST00000490605ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-3CDSENST00000420871ENST00000327896ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-3CDSENST00000420871ENST00000417561ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-3CDSENST00000420871ENST00000490605ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-5UTRENST00000295246ENST00000393526ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-5UTRENST00000295246ENST00000470789ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-5UTRENST00000419039ENST00000393526ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-5UTRENST00000419039ENST00000470789ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-5UTRENST00000420871ENST00000393526ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-
intron-5UTRENST00000420871ENST00000470789ANKRD36Cchr2

96614278

-FAM178Bchr2

97559788

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000456556ANKRD36Cchr296614278-ENST00000327896FAM178Bchr297559788-22301447701836588
ENST00000456556ANKRD36Cchr296614278-ENST00000417561FAM178Bchr297559788-22301447701836588
ENST00000456556ANKRD36Cchr296614278-ENST00000490605FAM178Bchr297559788-22281447701836588

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000456556ENST00000327896ANKRD36Cchr296614278-FAM178Bchr297559788-0.0036823730.9963176
ENST00000456556ENST00000417561ANKRD36Cchr296614278-FAM178Bchr297559788-0.0036823730.9963176
ENST00000456556ENST00000490605ANKRD36Cchr296614278-FAM178Bchr297559788-0.0036662280.9963337

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Fusion Genomic Features for ANKRD36C-FAM178B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANKRD36C-FAM178B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:96614278/chr2:97559788)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD36C

Q5JPF3

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD36Cchr2:96614278chr2:97559788ENST00000456556-1767130_1594541779.0RepeatNote=ANK 3
HgeneANKRD36Cchr2:96614278chr2:97559788ENST00000456556-1767163_1924541779.0RepeatNote=ANK 4
HgeneANKRD36Cchr2:96614278chr2:97559788ENST00000456556-1767196_2254541779.0RepeatNote=ANK 5
HgeneANKRD36Cchr2:96614278chr2:97559788ENST00000456556-176764_934541779.0RepeatNote=ANK 1
HgeneANKRD36Cchr2:96614278chr2:97559788ENST00000456556-176797_1264541779.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD36Cchr2:96614278chr2:97559788ENST00000456556-17671157_11874541779.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD36Cchr2:96614278chr2:97559788ENST00000456556-17671247_13334541779.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD36Cchr2:96614278chr2:97559788ENST00000456556-17671362_14804541779.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD36Cchr2:96614278chr2:97559788ENST00000456556-17671544_17684541779.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for ANKRD36C-FAM178B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4716_4716_1_ANKRD36C-FAM178B_ANKRD36C_chr2_96614278_ENST00000456556_FAM178B_chr2_97559788_ENST00000327896_length(transcript)=2230nt_BP=1447nt
TTTGCCTGTTGTTGCTCTTCGGAGGCGGCGATCCCCGAAGGCGAGCTGAAATACGGCTGCAGGCTACAATTTGCAGCCGACCATTATGGA
TGACAAGGAGCCGAAGAGGTGGCCCACCCTCAGGGACCGCTTGTGCTCGGATGGCTTCTTATTTCCCCAATACCCCATTAAACCGTATCA
TCTGAAGGGGATCCACAGAGCTGTCTTCTATCGTGATCTGGAGGAACTGAAGTTCGTTCTGCTCACGCGTTATGACATCAATAAGAGAGA
CAGGAAGGAAAGGACCGCCCTACATTTGGCCTGTGCCACTGGCCAACCGGAAATGGTACATCTCCTGGTGTCCAGAAGATGTGAGCTTAA
CCTCTGCGACCGTGAAGACAGGACACCTCTGATCAAGGCTGTACAACTGAGGCAGGAGGCTTGTGCAACTCTTCTGCTGCAAAATGGCGC
CGATCCAAATATTACGGATGTCTTTGGAAGGACTGCTCTGCACTACGCTGTGTATAATGAAGATACATCCATGATAGAAAAACTTCTTTC
ATATGGTGCAAATATTGAAGAATGCAGCGAGGATGAATATCCGCCACTGTTCCTTGCTGTGAGTCAAAGAAAAGTGAAAATGGTGGAATT
TTTATTAAAGAAAAAAGCAAATATAAATGCCGTTGATTATCTTGGCAGATCAGCCCTCATACATGCTGTTACTCTTGGAGAAAAAGATAT
AGTCATTCTTCTTCTGCAGCACAATATTGATGTGTTTTCTCGAGATGTGTATGGAAAGCTTGCAGAAGATTATGCCAGCGAGGCTAAGAA
CAGAGTCATTTTTGAACTAATTTATGAATATGAAAGAAAGAAACATGAAGAGCTTTCTATAAATAGCAATCCAGTGTCTTCTCAGAAACA
ACCAGCCTTGAAGGCTACAAGTGGCAAGGAAGATTCTATCTCGAATATAGCCACAGAAATAAAGGATGGACAAAAATCTGGGACAGTGTC
TTCTCAGAAACAACCGGCCTTGAAGGGTACAAGTGACAAGAACGATTCTGTTTCGAACACAGCCACAGAAATAAAAGATGAACAAAAATC
TGGGACAGTGTCTTCTCAGAAACAACCGGCCTTGAAGGATACAAGTGACAAGAACGATTCTGTTTCGAACACAGCCACAGAAATAAAAGA
TGAACAAAAATCTGGGACAGTGCTTCCTGCTGTTGAACAGTGTTTAAACAGGAGTCTCTACAGACCGGATGCTGTTGCACAGCCTGTGAC
AGAGGATGAGTTTGCTTTGGAATCTGAGATTATTTCAAAACTATACATCCCAAAGAGAAAGATTATTTCTCCACGATCTATAGAAGATGT
GCTTCCTCCTGTTGAAGAGGCTGTTGACAGGTGTCTCTACCTACTGGACCGTTTTGCACAGGCTGTGACAAAGGATAAGTTTGCTTTGGA
ATCTGAGCTGTCCTCGCTCAGCCGGCTCCTGGGCCTCATGAGGCCATCATCTCTCAGGCAATACCTGGACTCTGTGCCCTTGCCACCCTG
CCAGGAGCAACAGCCAAAGGCTAGTGCCGAGCTAGACCACAAGGCCTGCTACCTGTGCCACAGCTTGCTGATGCTGGCCGGGGTAGTTGT
TAGCTGCCAGGACATCACTCCAGACCAGTGGGGCGAGCTGCAGCTGCTGTGCATGCAGTTGGACCGCCACATCAGCACGCAGATCCGGGA
GAGCCCCCAGGCCATGCACCGCACCATGCTCAAGGACCTGGCTACCCAGACCTACATCCGTTGGCAGGAGCTGCTGACCCACTGCCAGCC
CCAGGCCCAGTATTTCAGCCCCTGGAAAGACATCTAAAGGGACAGGGTCAGGGCAGCCCAGGGCTCCTGGCTTCAGCAGGAAGTGAACAG
GCTCAGGGAACTGGAGGAAGCGAAGCATCAAGGCCAGAGGAGGCCACATGCTGACCAGCCTGATGAGGCAAGAGCCTGCCCCTGCCACCG
CCCCGACCCCTCTCCTCTCTGCAAGAGCCTGCCTCTGCCACCGCCCCGACCCCCTCTCCTCTCAGCAAGGGATGGGCCTCTCTGCCTCGC
CCACCCCTCAGCCCTCCTCCCAGCCATCTCCTCTTCCCTAAGGCCTCTGTCTCCATAGCTCTGGTTTCCCTGGGCCTCAGTCCTCCCCAC

>4716_4716_1_ANKRD36C-FAM178B_ANKRD36C_chr2_96614278_ENST00000456556_FAM178B_chr2_97559788_ENST00000327896_length(amino acids)=588AA_BP=1
MQPTIMDDKEPKRWPTLRDRLCSDGFLFPQYPIKPYHLKGIHRAVFYRDLEELKFVLLTRYDINKRDRKERTALHLACATGQPEMVHLLV
SRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGADPNITDVFGRTALHYAVYNEDTSMIEKLLSYGANIEECSEDEYPPLFLAVSQR
KVKMVEFLLKKKANINAVDYLGRSALIHAVTLGEKDIVILLLQHNIDVFSRDVYGKLAEDYASEAKNRVIFELIYEYERKKHEELSINSN
PVSSQKQPALKATSGKEDSISNIATEIKDGQKSGTVSSQKQPALKGTSDKNDSVSNTATEIKDEQKSGTVSSQKQPALKDTSDKNDSVSN
TATEIKDEQKSGTVLPAVEQCLNRSLYRPDAVAQPVTEDEFALESEIISKLYIPKRKIISPRSIEDVLPPVEEAVDRCLYLLDRFAQAVT
KDKFALESELSSLSRLLGLMRPSSLRQYLDSVPLPPCQEQQPKASAELDHKACYLCHSLLMLAGVVVSCQDITPDQWGELQLLCMQLDRH

--------------------------------------------------------------
>4716_4716_2_ANKRD36C-FAM178B_ANKRD36C_chr2_96614278_ENST00000456556_FAM178B_chr2_97559788_ENST00000417561_length(transcript)=2230nt_BP=1447nt
TTTGCCTGTTGTTGCTCTTCGGAGGCGGCGATCCCCGAAGGCGAGCTGAAATACGGCTGCAGGCTACAATTTGCAGCCGACCATTATGGA
TGACAAGGAGCCGAAGAGGTGGCCCACCCTCAGGGACCGCTTGTGCTCGGATGGCTTCTTATTTCCCCAATACCCCATTAAACCGTATCA
TCTGAAGGGGATCCACAGAGCTGTCTTCTATCGTGATCTGGAGGAACTGAAGTTCGTTCTGCTCACGCGTTATGACATCAATAAGAGAGA
CAGGAAGGAAAGGACCGCCCTACATTTGGCCTGTGCCACTGGCCAACCGGAAATGGTACATCTCCTGGTGTCCAGAAGATGTGAGCTTAA
CCTCTGCGACCGTGAAGACAGGACACCTCTGATCAAGGCTGTACAACTGAGGCAGGAGGCTTGTGCAACTCTTCTGCTGCAAAATGGCGC
CGATCCAAATATTACGGATGTCTTTGGAAGGACTGCTCTGCACTACGCTGTGTATAATGAAGATACATCCATGATAGAAAAACTTCTTTC
ATATGGTGCAAATATTGAAGAATGCAGCGAGGATGAATATCCGCCACTGTTCCTTGCTGTGAGTCAAAGAAAAGTGAAAATGGTGGAATT
TTTATTAAAGAAAAAAGCAAATATAAATGCCGTTGATTATCTTGGCAGATCAGCCCTCATACATGCTGTTACTCTTGGAGAAAAAGATAT
AGTCATTCTTCTTCTGCAGCACAATATTGATGTGTTTTCTCGAGATGTGTATGGAAAGCTTGCAGAAGATTATGCCAGCGAGGCTAAGAA
CAGAGTCATTTTTGAACTAATTTATGAATATGAAAGAAAGAAACATGAAGAGCTTTCTATAAATAGCAATCCAGTGTCTTCTCAGAAACA
ACCAGCCTTGAAGGCTACAAGTGGCAAGGAAGATTCTATCTCGAATATAGCCACAGAAATAAAGGATGGACAAAAATCTGGGACAGTGTC
TTCTCAGAAACAACCGGCCTTGAAGGGTACAAGTGACAAGAACGATTCTGTTTCGAACACAGCCACAGAAATAAAAGATGAACAAAAATC
TGGGACAGTGTCTTCTCAGAAACAACCGGCCTTGAAGGATACAAGTGACAAGAACGATTCTGTTTCGAACACAGCCACAGAAATAAAAGA
TGAACAAAAATCTGGGACAGTGCTTCCTGCTGTTGAACAGTGTTTAAACAGGAGTCTCTACAGACCGGATGCTGTTGCACAGCCTGTGAC
AGAGGATGAGTTTGCTTTGGAATCTGAGATTATTTCAAAACTATACATCCCAAAGAGAAAGATTATTTCTCCACGATCTATAGAAGATGT
GCTTCCTCCTGTTGAAGAGGCTGTTGACAGGTGTCTCTACCTACTGGACCGTTTTGCACAGGCTGTGACAAAGGATAAGTTTGCTTTGGA
ATCTGAGCTGTCCTCGCTCAGCCGGCTCCTGGGCCTCATGAGGCCATCATCTCTCAGGCAATACCTGGACTCTGTGCCCTTGCCACCCTG
CCAGGAGCAACAGCCAAAGGCTAGTGCCGAGCTAGACCACAAGGCCTGCTACCTGTGCCACAGCTTGCTGATGCTGGCCGGGGTAGTTGT
TAGCTGCCAGGACATCACTCCAGACCAGTGGGGCGAGCTGCAGCTGCTGTGCATGCAGTTGGACCGCCACATCAGCACGCAGATCCGGGA
GAGCCCCCAGGCCATGCACCGCACCATGCTCAAGGACCTGGCTACCCAGACCTACATCCGTTGGCAGGAGCTGCTGACCCACTGCCAGCC
CCAGGCCCAGTATTTCAGCCCCTGGAAAGACATCTAAAGGGACAGGGTCAGGGCAGCCCAGGGCTCCTGGCTTCAGCAGGAAGTGAACAG
GCTCAGGGAACTGGAGGAAGCGAAGCATCAAGGCCAGAGGAGGCCACATGCTGACCAGCCTGATGAGGCAAGAGCCTGCCCCTGCCACCG
CCCCGACCCCTCTCCTCTCTGCAAGAGCCTGCCTCTGCCACCGCCCCGACCCCCTCTCCTCTCAGCAAGGGATGGGCCTCTCTGCCTCGC
CCACCCCTCAGCCCTCCTCCCAGCCATCTCCTCTTCCCTAAGGCCTCTGTCTCCATAGCTCTGGTTTCCCTGGGCCTCAGTCCTCCCCAC

>4716_4716_2_ANKRD36C-FAM178B_ANKRD36C_chr2_96614278_ENST00000456556_FAM178B_chr2_97559788_ENST00000417561_length(amino acids)=588AA_BP=1
MQPTIMDDKEPKRWPTLRDRLCSDGFLFPQYPIKPYHLKGIHRAVFYRDLEELKFVLLTRYDINKRDRKERTALHLACATGQPEMVHLLV
SRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGADPNITDVFGRTALHYAVYNEDTSMIEKLLSYGANIEECSEDEYPPLFLAVSQR
KVKMVEFLLKKKANINAVDYLGRSALIHAVTLGEKDIVILLLQHNIDVFSRDVYGKLAEDYASEAKNRVIFELIYEYERKKHEELSINSN
PVSSQKQPALKATSGKEDSISNIATEIKDGQKSGTVSSQKQPALKGTSDKNDSVSNTATEIKDEQKSGTVSSQKQPALKDTSDKNDSVSN
TATEIKDEQKSGTVLPAVEQCLNRSLYRPDAVAQPVTEDEFALESEIISKLYIPKRKIISPRSIEDVLPPVEEAVDRCLYLLDRFAQAVT
KDKFALESELSSLSRLLGLMRPSSLRQYLDSVPLPPCQEQQPKASAELDHKACYLCHSLLMLAGVVVSCQDITPDQWGELQLLCMQLDRH

--------------------------------------------------------------
>4716_4716_3_ANKRD36C-FAM178B_ANKRD36C_chr2_96614278_ENST00000456556_FAM178B_chr2_97559788_ENST00000490605_length(transcript)=2228nt_BP=1447nt
TTTGCCTGTTGTTGCTCTTCGGAGGCGGCGATCCCCGAAGGCGAGCTGAAATACGGCTGCAGGCTACAATTTGCAGCCGACCATTATGGA
TGACAAGGAGCCGAAGAGGTGGCCCACCCTCAGGGACCGCTTGTGCTCGGATGGCTTCTTATTTCCCCAATACCCCATTAAACCGTATCA
TCTGAAGGGGATCCACAGAGCTGTCTTCTATCGTGATCTGGAGGAACTGAAGTTCGTTCTGCTCACGCGTTATGACATCAATAAGAGAGA
CAGGAAGGAAAGGACCGCCCTACATTTGGCCTGTGCCACTGGCCAACCGGAAATGGTACATCTCCTGGTGTCCAGAAGATGTGAGCTTAA
CCTCTGCGACCGTGAAGACAGGACACCTCTGATCAAGGCTGTACAACTGAGGCAGGAGGCTTGTGCAACTCTTCTGCTGCAAAATGGCGC
CGATCCAAATATTACGGATGTCTTTGGAAGGACTGCTCTGCACTACGCTGTGTATAATGAAGATACATCCATGATAGAAAAACTTCTTTC
ATATGGTGCAAATATTGAAGAATGCAGCGAGGATGAATATCCGCCACTGTTCCTTGCTGTGAGTCAAAGAAAAGTGAAAATGGTGGAATT
TTTATTAAAGAAAAAAGCAAATATAAATGCCGTTGATTATCTTGGCAGATCAGCCCTCATACATGCTGTTACTCTTGGAGAAAAAGATAT
AGTCATTCTTCTTCTGCAGCACAATATTGATGTGTTTTCTCGAGATGTGTATGGAAAGCTTGCAGAAGATTATGCCAGCGAGGCTAAGAA
CAGAGTCATTTTTGAACTAATTTATGAATATGAAAGAAAGAAACATGAAGAGCTTTCTATAAATAGCAATCCAGTGTCTTCTCAGAAACA
ACCAGCCTTGAAGGCTACAAGTGGCAAGGAAGATTCTATCTCGAATATAGCCACAGAAATAAAGGATGGACAAAAATCTGGGACAGTGTC
TTCTCAGAAACAACCGGCCTTGAAGGGTACAAGTGACAAGAACGATTCTGTTTCGAACACAGCCACAGAAATAAAAGATGAACAAAAATC
TGGGACAGTGTCTTCTCAGAAACAACCGGCCTTGAAGGATACAAGTGACAAGAACGATTCTGTTTCGAACACAGCCACAGAAATAAAAGA
TGAACAAAAATCTGGGACAGTGCTTCCTGCTGTTGAACAGTGTTTAAACAGGAGTCTCTACAGACCGGATGCTGTTGCACAGCCTGTGAC
AGAGGATGAGTTTGCTTTGGAATCTGAGATTATTTCAAAACTATACATCCCAAAGAGAAAGATTATTTCTCCACGATCTATAGAAGATGT
GCTTCCTCCTGTTGAAGAGGCTGTTGACAGGTGTCTCTACCTACTGGACCGTTTTGCACAGGCTGTGACAAAGGATAAGTTTGCTTTGGA
ATCTGAGCTGTCCTCGCTCAGCCGGCTCCTGGGCCTCATGAGGCCATCATCTCTCAGGCAATACCTGGACTCTGTGCCCTTGCCACCCTG
CCAGGAGCAACAGCCAAAGGCTAGTGCCGAGCTAGACCACAAGGCCTGCTACCTGTGCCACAGCTTGCTGATGCTGGCCGGGGTAGTTGT
TAGCTGCCAGGACATCACTCCAGACCAGTGGGGCGAGCTGCAGCTGCTGTGCATGCAGTTGGACCGCCACATCAGCACGCAGATCCGGGA
GAGCCCCCAGGCCATGCACCGCACCATGCTCAAGGACCTGGCTACCCAGACCTACATCCGTTGGCAGGAGCTGCTGACCCACTGCCAGCC
CCAGGCCCAGTATTTCAGCCCCTGGAAAGACATCTAAAGGGACAGGGTCAGGGCAGCCCAGGGCTCCTGGCTTCAGCAGGAAGTGAACAG
GCTCAGGGAACTGGAGGAAGCGAAGCATCAAGGCCAGAGGAGGCCACATGCTGACCAGCCTGATGAGGCAAGAGCCTGCCCCTGCCACCG
CCCCGACCCCTCTCCTCTCTGCAAGAGCCTGCCTCTGCCACCGCCCCGACCCCCTCTCCTCTCAGCAAGGGATGGGCCTCTCTGCCTCGC
CCACCCCTCAGCCCTCCTCCCAGCCATCTCCTCTTCCCTAAGGCCTCTGTCTCCATAGCTCTGGTTTCCCTGGGCCTCAGTCCTCCCCAC

>4716_4716_3_ANKRD36C-FAM178B_ANKRD36C_chr2_96614278_ENST00000456556_FAM178B_chr2_97559788_ENST00000490605_length(amino acids)=588AA_BP=1
MQPTIMDDKEPKRWPTLRDRLCSDGFLFPQYPIKPYHLKGIHRAVFYRDLEELKFVLLTRYDINKRDRKERTALHLACATGQPEMVHLLV
SRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGADPNITDVFGRTALHYAVYNEDTSMIEKLLSYGANIEECSEDEYPPLFLAVSQR
KVKMVEFLLKKKANINAVDYLGRSALIHAVTLGEKDIVILLLQHNIDVFSRDVYGKLAEDYASEAKNRVIFELIYEYERKKHEELSINSN
PVSSQKQPALKATSGKEDSISNIATEIKDGQKSGTVSSQKQPALKGTSDKNDSVSNTATEIKDEQKSGTVSSQKQPALKDTSDKNDSVSN
TATEIKDEQKSGTVLPAVEQCLNRSLYRPDAVAQPVTEDEFALESEIISKLYIPKRKIISPRSIEDVLPPVEEAVDRCLYLLDRFAQAVT
KDKFALESELSSLSRLLGLMRPSSLRQYLDSVPLPPCQEQQPKASAELDHKACYLCHSLLMLAGVVVSCQDITPDQWGELQLLCMQLDRH

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Fusion Gene PPI Analysis for ANKRD36C-FAM178B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD36C-FAM178B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD36C-FAM178B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource