Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARRB1-ANKFN1 (FusionGDB2 ID:HG408TG162282)

Fusion Gene Summary for ARRB1-ANKFN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARRB1-ANKFN1
Fusion gene ID: hg408tg162282
HgeneTgene
Gene symbol

ARRB1

ANKFN1

Gene ID

408

162282

Gene namearrestin beta 1ankyrin repeat and fibronectin type III domain containing 1
SynonymsARB1|ARR1-
Cytomap('ARRB1')('ANKFN1')

11q13.4

17q22

Type of geneprotein-codingprotein-coding
Descriptionbeta-arrestin-1arrestin 2non-visual arrestin-2ankyrin repeat and fibronectin type-III domain-containing protein 1
Modification date2020031320200313
UniProtAcc.

Q8N957

Ensembl transtripts involved in fusion geneENST00000360025, ENST00000393505, 
ENST00000420843, 
Fusion gene scores* DoF score18 X 10 X 9=162017 X 16 X 6=1632
# samples 2319
** MAII scorelog2(23/1620*10)=-2.81628804682761
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1632*10)=-3.10256973364055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARRB1 [Title/Abstract] AND ANKFN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARRB1(75062632)-ANKFN1(54262110), # samples:2
ARRB1(75062632)-ANKFN1(54305278), # samples:2
Anticipated loss of major functional domain due to fusion event.ARRB1-ANKFN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARRB1-ANKFN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARRB1-ANKFN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARRB1-ANKFN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARRB1

GO:0031397

negative regulation of protein ubiquitination

16378096

HgeneARRB1

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16378096

HgeneARRB1

GO:0032715

negative regulation of interleukin-6 production

16378096

HgeneARRB1

GO:0032717

negative regulation of interleukin-8 production

16378096

HgeneARRB1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10644702


check buttonFusion gene breakpoints across ARRB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ANKFN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A155-01AARRB1chr11

75062632

-ANKFN1chr17

54262110

+
ChimerDB4BRCATCGA-E2-A155-01AARRB1chr11

75062632

-ANKFN1chr17

54305278

+


Top

Fusion Gene ORF analysis for ARRB1-ANKFN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000360025ENST00000574292ARRB1chr11

75062632

-ANKFN1chr17

54262110

+
5CDS-3UTRENST00000360025ENST00000574292ARRB1chr11

75062632

-ANKFN1chr17

54305278

+
5CDS-3UTRENST00000393505ENST00000574292ARRB1chr11

75062632

-ANKFN1chr17

54262110

+
5CDS-3UTRENST00000393505ENST00000574292ARRB1chr11

75062632

-ANKFN1chr17

54305278

+
5CDS-3UTRENST00000420843ENST00000574292ARRB1chr11

75062632

-ANKFN1chr17

54262110

+
5CDS-3UTRENST00000420843ENST00000574292ARRB1chr11

75062632

-ANKFN1chr17

54305278

+
5CDS-intronENST00000360025ENST00000318698ARRB1chr11

75062632

-ANKFN1chr17

54262110

+
5CDS-intronENST00000360025ENST00000566473ARRB1chr11

75062632

-ANKFN1chr17

54262110

+
5CDS-intronENST00000393505ENST00000318698ARRB1chr11

75062632

-ANKFN1chr17

54262110

+
5CDS-intronENST00000393505ENST00000566473ARRB1chr11

75062632

-ANKFN1chr17

54262110

+
5CDS-intronENST00000420843ENST00000318698ARRB1chr11

75062632

-ANKFN1chr17

54262110

+
5CDS-intronENST00000420843ENST00000566473ARRB1chr11

75062632

-ANKFN1chr17

54262110

+
In-frameENST00000360025ENST00000318698ARRB1chr11

75062632

-ANKFN1chr17

54305278

+
In-frameENST00000360025ENST00000566473ARRB1chr11

75062632

-ANKFN1chr17

54305278

+
In-frameENST00000393505ENST00000318698ARRB1chr11

75062632

-ANKFN1chr17

54305278

+
In-frameENST00000393505ENST00000566473ARRB1chr11

75062632

-ANKFN1chr17

54305278

+
In-frameENST00000420843ENST00000318698ARRB1chr11

75062632

-ANKFN1chr17

54305278

+
In-frameENST00000420843ENST00000566473ARRB1chr11

75062632

-ANKFN1chr17

54305278

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420843ARRB1chr1175062632-ENST00000318698ANKFN1chr1754305278+2488118162388790
ENST00000420843ARRB1chr1175062632-ENST00000566473ANKFN1chr1754305278+39371181635461176
ENST00000393505ARRB1chr1175062632-ENST00000318698ANKFN1chr1754305278+2612242442512822
ENST00000393505ARRB1chr1175062632-ENST00000566473ANKFN1chr1754305278+40612424436701208
ENST00000360025ARRB1chr1175062632-ENST00000318698ANKFN1chr1754305278+2488118162388790
ENST00000360025ARRB1chr1175062632-ENST00000566473ANKFN1chr1754305278+39371181635461176

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420843ENST00000318698ARRB1chr1175062632-ANKFN1chr1754305278+0.0054158380.99458414
ENST00000420843ENST00000566473ARRB1chr1175062632-ANKFN1chr1754305278+0.001593490.9984066
ENST00000393505ENST00000318698ARRB1chr1175062632-ANKFN1chr1754305278+0.0049749730.995025
ENST00000393505ENST00000566473ARRB1chr1175062632-ANKFN1chr1754305278+0.0017926290.99820733
ENST00000360025ENST00000318698ARRB1chr1175062632-ANKFN1chr1754305278+0.0054158380.99458414
ENST00000360025ENST00000566473ARRB1chr1175062632-ANKFN1chr1754305278+0.001593490.9984066

Top

Fusion Genomic Features for ARRB1-ANKFN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARRB1chr1175062631-ANKFN1chr1754262109+0.0008344130.99916565
ARRB1chr1175062631-ANKFN1chr1754305277+5.22E-060.99999475
ARRB1chr1175062631-ANKFN1chr1754262109+0.0008344130.99916565
ARRB1chr1175062631-ANKFN1chr1754305277+5.22E-060.99999475

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ARRB1-ANKFN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:75062632/chr17:54262110)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANKFN1

Q8N957

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKFN1chr11:75062632chr17:54305278ENST00000318698017205_2367764.0Coiled coilOntology_term=ECO:0000255
TgeneANKFN1chr11:75062632chr17:54305278ENST00000318698017273_3697764.0DomainFibronectin type-III
TgeneANKFN1chr11:75062632chr17:54305278ENST00000318698017136_1657764.0RepeatNote=ANK 1
TgeneANKFN1chr11:75062632chr17:54305278ENST00000318698017173_2027764.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARRB1chr11:75062632chr17:54305278ENST00000360025-115385_3956411.0MotifNote=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif
HgeneARRB1chr11:75062632chr17:54305278ENST00000420843-116385_3956419.0MotifNote=[DE]-X(1%2C2)-F-X-X-[FL]-X-X-X-R motif


Top

Fusion Gene Sequence for ARRB1-ANKFN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6832_6832_1_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000360025_ANKFN1_chr17_54305278_ENST00000318698_length(transcript)=2488nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGAGGCTACTCTTTAAAGACAGGCATTTTACTTGCAGCAAAATAATAGGAAGGAGATTCGCTTG
CTTTGCACAGAGGCTGAGCCACAGGAGAAAGCAAAGCCAATGTGATTTATTGAATGAAAGCACTGGACAATTACCAACAACTTGTTCCTC
TGCTGCCTCGAACAGCATAAACTGGAATTGTCGTGTGAAAATGACGCAACAAATGCAAAATTTACATCTCTGTCAGTCAAAAAAACATAG
TGCTCCCTCATCTCCCAACGCAGCCAAACGCCTGTACAGGAACCTCTCTGAGAAACTGAAAGGGAGCCACTCTTCCTTCGATGAGGCCTA
TTTTAGGACAAGAACTGATCGGCTGAGTCTCAGGAAGACCTCGGTGAATTTCCAGGGCAATGAAGCCATGTTTGAGGCAGTCGAACAGCA
GGACATGGATGCTGTGCAGATCCTCCTGTATCAGTACACACCAGAAGAACTTGACCTCAACACACCTAACAGCGAGGGCTTGACACCCCT
GGATATTGCCATCATGACCAACAATGTGCCCATTGCAAGGATTCTTCTGAGGACAGGGGCCCGAGAAAGTCCACACTTTGTCAGCCTGGA
AAGCCGAGCAATGCACCTCAACACACTGGTCCAGGAAGCCCAGGAGAGGGTGAGTGAACTGTCTGCCCAGGTGGAGAATGAAGGATTCAC
TCTGGACAACACAGAGAAAGAGAAGCAGCTGAAAGCTTGGGAGTGGAGGTATCGGCTCTACAGACGCATGAAAACAGGCTTTGAGCATGC
CAGAGCCCCTGAGATGCCAACCAATGTCTGTCTCATGGTAACCAGCAGCACATCACTCACTGTCAGCTTCCAAGAGCCTCTTAGCGTCAA
TGCAGCTGTAGTAACCAGGTATAAAGTGGAATGGAGTATGTCCGAAGACTTTTCTCCTTTGGCTGGAGAAATCATCATGGATAATCTGCA
GACTCTGAGATGCACAATCACAGGACTTACAATGGGCCAACAGTATTTTGTTCAAGTCTCGGCTTACAATATGAAAGGATGGGGACCTGC
TCAGACCACGACACCGGCATGTGCCTCTCCTTCTAACTGGAAAGACTATGACGACAGAGAGCCCAGACACAAGGGACAGAGTGAAGTTTT
GGAAGGTCTGCTGCAGCAGGTCCGAGCCCTTCATCAGCATTACAGTTGCCGGGAAAGCACAAAATTACAAACCACAGGCCGCAAGCAGTC
AGTCTCAAGAAGCCTGAAACACCTGTTCCATTCCTCGAACAAGTTTGTGAAGACCTTAAAACGGGGACTCTACATAGCCGTTATATTTTA
TTACAAAGACAATATCTTAGTCACCAATGAAGATCAAGTACCAATTGTTGAAATAGATGACTCTCACACCAGTTCTATTACACAAGATTT
TCTGTGGTTCACGAAGCTGTCTTGTATGTGGGAAGATATAAGGTGGCTGAGGCAAAGCATACCAATATCCTCATCCTCATCCACAGTGCT
GCAAACTCGGCAGAAGATGCTCGCAGCAACAGCACAGCTACAGAATTTACTTGGGACACACAACTTGGGAAGAGTTTACTATGAGCCCAT
TAAAGATCGACATGGAAACATACTCATAGTCACCATCAGGGAGGTGGAGATGCTTTATTCATTTTTTAATGGCAAATGGATGCAGATCTC
AAAGCTGCAAAGCCAGAGAAAGTCTCTATCAACACCTGAGGAGCCAACAGCTTTAGACATTCTACTGATAACCATCCAGGATATTCTATC
CTATCACAAAAGGAGTCATCAGCGTCTCTTTCCTGGATTATATCTGGGTTACCTAAAGCTCTGTAGCTCTGTGGATCAAATCAAAGTTCT
TGTTACCCAAAAGTTGCCCAACATTCTCTGCCACGTGAAGATCCGTGAAAACAATAATATTTCTAGAGAGGAATGGGAATGGATCCAAAA
GCTTTCTGGCTCTGAATCTATGGAAAGTGTGGATCATACTTCTGACTGCCCCATGCAATTGTTCTTCTACGAGCTCCAGATGGCAGTGAA
AGCTCTCCTTCAGCAGATCAATATACCTCTACACCAGGCAAGGAACTTCCGCCTCTACACACAGGAGGTGTTGGAAATGGGTCACAATGT
GTCCTTTCTTCTCCTGCTCCCTGCCTCAGACGACGTCTGTACAGCCCCAGGACAGAATAATCCTTACACCCCACACTCAGGGTTTCTTAA
CCTCCCTCTTCAGATGTTTGAACTTGGTATAGTAGCTTGTTTCACCTAGAAATATTAACCCAGCCTCCTTATAATAAAATCACAAAGTTA

>6832_6832_1_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000360025_ANKFN1_chr17_54305278_ENST00000318698_length(amino acids)=790AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPRLLFKDRHFTCSKIIGRRFACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNS
INWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFDEAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAV
QILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSLESRAMHLNTLVQEAQERVSELSAQVENEGFTLDNTE
KEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCT
ITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQSEVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSL
KHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSITQDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQK
MLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWMQISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRS
HQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEWIQKLSGSESMESVDHTSDCPMQLFFYELQMAVKALLQQ

--------------------------------------------------------------
>6832_6832_2_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000360025_ANKFN1_chr17_54305278_ENST00000566473_length(transcript)=3937nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGAGGCTACTCTTTAAAGACAGGCATTTTACTTGCAGCAAAATAATAGGAAGGAGATTCGCTTG
CTTTGCACAGAGGCTGAGCCACAGGAGAAAGCAAAGCCAATGTGATTTATTGAATGAAAGCACTGGACAATTACCAACAACTTGTTCCTC
TGCTGCCTCGAACAGCATAAACTGGAATTGTCGTGTGAAAATGACGCAACAAATGCAAAATTTACATCTCTGTCAGTCAAAAAAACATAG
TGCTCCCTCATCTCCCAACGCAGCCAAACGCCTGTACAGGAACCTCTCTGAGAAACTGAAAGGGAGCCACTCTTCCTTCGATGAGGCCTA
TTTTAGGACAAGAACTGATCGGCTGAGTCTCAGGAAGACCTCGGTGAATTTCCAGGGCAATGAAGCCATGTTTGAGGCAGTCGAACAGCA
GGACATGGATGCTGTGCAGATCCTCCTGTATCAGTACACACCAGAAGAACTTGACCTCAACACACCTAACAGCGAGGGCTTGACACCCCT
GGATATTGCCATCATGACCAACAATGTGCCCATTGCAAGGATTCTTCTGAGGACAGGGGCCCGAGAAAGTCCACACTTTGTCAGCCTGGA
AAGCCGAGCAATGCACCTCAACACACTGGTCCAGGAAGCCCAGGAGAGGGTGAGTGAACTGTCTGCCCAGGTGGAGAATGAAGGATTCAC
TCTGGACAACACAGAGAAAGAGAAGCAGCTGAAAGCTTGGGAGTGGAGGTATCGGCTCTACAGACGCATGAAAACAGGCTTTGAGCATGC
CAGAGCCCCTGAGATGCCAACCAATGTCTGTCTCATGGTAACCAGCAGCACATCACTCACTGTCAGCTTCCAAGAGCCTCTTAGCGTCAA
TGCAGCTGTAGTAACCAGGTATAAAGTGGAATGGAGTATGTCCGAAGACTTTTCTCCTTTGGCTGGAGAAATCATCATGGATAATCTGCA
GACTCTGAGATGCACAATCACAGGACTTACAATGGGCCAACAGTATTTTGTTCAAGTCTCGGCTTACAATATGAAAGGATGGGGACCTGC
TCAGACCACGACACCGGCATGTGCCTCTCCTTCTAACTGGAAAGACTATGACGACAGAGAGCCCAGACACAAGGGACAGAGTGAAGTTTT
GGAAGGTCTGCTGCAGCAGGTCCGAGCCCTTCATCAGCATTACAGTTGCCGGGAAAGCACAAAATTACAAACCACAGGCCGCAAGCAGTC
AGTCTCAAGAAGCCTGAAACACCTGTTCCATTCCTCGAACAAGTTTGTGAAGACCTTAAAACGGGGACTCTACATAGCCGTTATATTTTA
TTACAAAGACAATATCTTAGTCACCAATGAAGATCAAGTACCAATTGTTGAAATAGATGACTCTCACACCAGTTCTATTACACAAGATTT
TCTGTGGTTCACGAAGCTGTCTTGTATGTGGGAAGATATAAGGTGGCTGAGGCAAAGCATACCAATATCCTCATCCTCATCCACAGTGCT
GCAAACTCGGCAGAAGATGCTCGCAGCAACAGCACAGCTACAGAATTTACTTGGGACACACAACTTGGGAAGAGTTTACTATGAGCCCAT
TAAAGATCGACATGGAAACATACTCATAGTCACCATCAGGGAGGTGGAGATGCTTTATTCATTTTTTAATGGCAAATGGATGCAGATCTC
AAAGCTGCAAAGCCAGAGAAAGTCTCTATCAACACCTGAGGAGCCAACAGCTTTAGACATTCTACTGATAACCATCCAGGATATTCTATC
CTATCACAAAAGGAGTCATCAGCGTCTCTTTCCTGGATTATATCTGGGTTACCTAAAGCTCTGTAGCTCTGTGGATCAAATCAAAGTTCT
TGTTACCCAAAAGTTGCCCAACATTCTCTGCCACGTGAAGATCCGTGAAAACAATAATATTTCTAGAGAGGAATGGGAATGGATCCAAAA
GCTTTCTGGCTCTGAATCTATGGAAAGTGTGGATCATACTTCTGACTGCCCCATGCAATTGTTCTTCTACGAGCTCCAGATGGCAGTGAA
AGCTCTCCTTCAGCAGATCAATATACCTCTACACCAGGCAAGGAACTTCCGCCTCTACACACAGGAGGTGTTGGAAATGGGTCACAATGT
GTCCTTTCTTCTCCTGCTCCCTGCCTCAGACGACGTCTGTACAGCCCCAGGACAGAATAATCCTTACACCCCACACTCAGGGTTTCTTAA
CCTCCCTCTTCAGATGTTTGAACTTGTTCATTTTTGCAGCTACAGAGAGAAATTTATTAGTCTGTATTGCCGCCTTTCTGCTGTTGTGGA
GCTGGATTCTCTGAACACCCAACAGTCCCTCAGGGAAGCAATCTCAGACAGCGAGGTTGCAGCTGCCAAACAAAGACACCAGCAAGTTTT
AGATTTCATTCAGCAAATAGATGAAGTCTGGCGTGAAATGAGATGGATCATGGATGCTCTACAGTATGCAAGATACAAACAACCAGTTTC
TGGCTTGCCCATCACTAAGCTGATAGACCCCTCAGATGAGCAGAGCCTAAAGAAGATCAATTCTACATCATCATCACATATAGACTGTCT
TCCATCCCCACCCCCATCCCCAGAGATGCACAGAAGAAAGACAGTGAGTGATTCACAGCCCTGCTCTGATGAAGAAGCCTGCTCAGAAGT
CTTCCTCCCCACCAACAGTGACTACGACTCCAGCGATGCCCTGAGCCCCAGAGACCTGGACCTGGTCTACCTATCATCTCACGACATTGC
GCAGCAGACCCTTAGCGGCCTAAGCGGCAGCGCCCCCGACGTCCTGCAAGTGCACGACGTGAAAACCCCTCTGGGGCCGGGCCAGGATCC
CCAGGGCGAGGGCCCAAATCCCGATCACTCATGTGCCGAGTTTCTCCATAGCCTGACCCTCACGGGGTTCACACCCAAGAACCACGCCAA
GACTGTGTCCGGTGGGCGGCCCCCGCTAGGCTTCCTGGGAAAGCGGAAGCCAGGCAAGCACCCCCACTATGGCGGCTTCAGCCGCCATCA
TCGCTGGTTGCGCATCCACAGCGAGACCCAGTCGCTATCGCTCTCTGAGGGCATTTATACACAGCACCTGTCCCAGGCCTGTGGTCTGGC
CCAGGAGCCCAAGGAGGCCAAGCGGGCCGGCCCTGCCCTTGATGATCCCAGGGGCCTAACTCTGGCCCACGCTGCCAGCCTTCCTGAGGA
GCGGAACAGCAGTCTCCAGGACGCGAGGCCTTCCGTCCGCCGCCTCTACGTGGAGCCCTACGCAGCGGCCGTGGTGGCCCAGGACGAAAA
ACCATGGGCAAGCTTGAGCCCGCCCTCTGGAGGCCGCATCACCCTGCCCAGCCCCACTGGCCCCGATGTGAGTCAGGAGGGCCCCACCGC
CTCTCCCATGTCAGAAATACTCAGCAGCATGCTTTAGGGAGGCCCATCCCGGCTGTCCACCCCTCCATGGCTGCTACCTGCGTTTTACAT
CACCCTTACCCCCATCCTGCCCCACTGTGTACCCACTCATTTTCAAGCGTTTTGAATGTTATAAATACAAAGGTTACAAGTTCAAGGTCC
TCTTTTTTTGGAACAGAGTGGTGGGTGGAGGCCAGAGTTGCCAGTGCCATTCCCACTTCAGCCTAGAAAGGGCATGGGGGAGTTGTGTCA
ACATGGAATACGACATACAGTGACTCAAACATGCCACCCTGTTGGTGGCACCTATGACTGAAGCTGGCCATCCCAAAGAGAGACCCTCTG

>6832_6832_2_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000360025_ANKFN1_chr17_54305278_ENST00000566473_length(amino acids)=1176AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPRLLFKDRHFTCSKIIGRRFACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNS
INWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFDEAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAV
QILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSLESRAMHLNTLVQEAQERVSELSAQVENEGFTLDNTE
KEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCT
ITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQSEVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSL
KHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSITQDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQK
MLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWMQISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRS
HQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEWIQKLSGSESMESVDHTSDCPMQLFFYELQMAVKALLQQ
INIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSGFLNLPLQMFELVHFCSYREKFISLYCRLSAVVELDSLN
TQQSLREAISDSEVAAAKQRHQQVLDFIQQIDEVWREMRWIMDALQYARYKQPVSGLPITKLIDPSDEQSLKKINSTSSSHIDCLPSPPP
SPEMHRRKTVSDSQPCSDEEACSEVFLPTNSDYDSSDALSPRDLDLVYLSSHDIAQQTLSGLSGSAPDVLQVHDVKTPLGPGQDPQGEGP
NPDHSCAEFLHSLTLTGFTPKNHAKTVSGGRPPLGFLGKRKPGKHPHYGGFSRHHRWLRIHSETQSLSLSEGIYTQHLSQACGLAQEPKE
AKRAGPALDDPRGLTLAHAASLPEERNSSLQDARPSVRRLYVEPYAAAVVAQDEKPWASLSPPSGGRITLPSPTGPDVSQEGPTASPMSE

--------------------------------------------------------------
>6832_6832_3_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000393505_ANKFN1_chr17_54305278_ENST00000318698_length(transcript)=2612nt_BP=242nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGAGGCTACTCTTTAAAGACAGGCATTTTA
CTTGCAGCAAAATAATAGGAAGGAGATTCGCTTGCTTTGCACAGAGGCTGAGCCACAGGAGAAAGCAAAGCCAATGTGATTTATTGAATG
AAAGCACTGGACAATTACCAACAACTTGTTCCTCTGCTGCCTCGAACAGCATAAACTGGAATTGTCGTGTGAAAATGACGCAACAAATGC
AAAATTTACATCTCTGTCAGTCAAAAAAACATAGTGCTCCCTCATCTCCCAACGCAGCCAAACGCCTGTACAGGAACCTCTCTGAGAAAC
TGAAAGGGAGCCACTCTTCCTTCGATGAGGCCTATTTTAGGACAAGAACTGATCGGCTGAGTCTCAGGAAGACCTCGGTGAATTTCCAGG
GCAATGAAGCCATGTTTGAGGCAGTCGAACAGCAGGACATGGATGCTGTGCAGATCCTCCTGTATCAGTACACACCAGAAGAACTTGACC
TCAACACACCTAACAGCGAGGGCTTGACACCCCTGGATATTGCCATCATGACCAACAATGTGCCCATTGCAAGGATTCTTCTGAGGACAG
GGGCCCGAGAAAGTCCACACTTTGTCAGCCTGGAAAGCCGAGCAATGCACCTCAACACACTGGTCCAGGAAGCCCAGGAGAGGGTGAGTG
AACTGTCTGCCCAGGTGGAGAATGAAGGATTCACTCTGGACAACACAGAGAAAGAGAAGCAGCTGAAAGCTTGGGAGTGGAGGTATCGGC
TCTACAGACGCATGAAAACAGGCTTTGAGCATGCCAGAGCCCCTGAGATGCCAACCAATGTCTGTCTCATGGTAACCAGCAGCACATCAC
TCACTGTCAGCTTCCAAGAGCCTCTTAGCGTCAATGCAGCTGTAGTAACCAGGTATAAAGTGGAATGGAGTATGTCCGAAGACTTTTCTC
CTTTGGCTGGAGAAATCATCATGGATAATCTGCAGACTCTGAGATGCACAATCACAGGACTTACAATGGGCCAACAGTATTTTGTTCAAG
TCTCGGCTTACAATATGAAAGGATGGGGACCTGCTCAGACCACGACACCGGCATGTGCCTCTCCTTCTAACTGGAAAGACTATGACGACA
GAGAGCCCAGACACAAGGGACAGAGTGAAGTTTTGGAAGGTCTGCTGCAGCAGGTCCGAGCCCTTCATCAGCATTACAGTTGCCGGGAAA
GCACAAAATTACAAACCACAGGCCGCAAGCAGTCAGTCTCAAGAAGCCTGAAACACCTGTTCCATTCCTCGAACAAGTTTGTGAAGACCT
TAAAACGGGGACTCTACATAGCCGTTATATTTTATTACAAAGACAATATCTTAGTCACCAATGAAGATCAAGTACCAATTGTTGAAATAG
ATGACTCTCACACCAGTTCTATTACACAAGATTTTCTGTGGTTCACGAAGCTGTCTTGTATGTGGGAAGATATAAGGTGGCTGAGGCAAA
GCATACCAATATCCTCATCCTCATCCACAGTGCTGCAAACTCGGCAGAAGATGCTCGCAGCAACAGCACAGCTACAGAATTTACTTGGGA
CACACAACTTGGGAAGAGTTTACTATGAGCCCATTAAAGATCGACATGGAAACATACTCATAGTCACCATCAGGGAGGTGGAGATGCTTT
ATTCATTTTTTAATGGCAAATGGATGCAGATCTCAAAGCTGCAAAGCCAGAGAAAGTCTCTATCAACACCTGAGGAGCCAACAGCTTTAG
ACATTCTACTGATAACCATCCAGGATATTCTATCCTATCACAAAAGGAGTCATCAGCGTCTCTTTCCTGGATTATATCTGGGTTACCTAA
AGCTCTGTAGCTCTGTGGATCAAATCAAAGTTCTTGTTACCCAAAAGTTGCCCAACATTCTCTGCCACGTGAAGATCCGTGAAAACAATA
ATATTTCTAGAGAGGAATGGGAATGGATCCAAAAGCTTTCTGGCTCTGAATCTATGGAAAGTGTGGATCATACTTCTGACTGCCCCATGC
AATTGTTCTTCTACGAGCTCCAGATGGCAGTGAAAGCTCTCCTTCAGCAGATCAATATACCTCTACACCAGGCAAGGAACTTCCGCCTCT
ACACACAGGAGGTGTTGGAAATGGGTCACAATGTGTCCTTTCTTCTCCTGCTCCCTGCCTCAGACGACGTCTGTACAGCCCCAGGACAGA
ATAATCCTTACACCCCACACTCAGGGTTTCTTAACCTCCCTCTTCAGATGTTTGAACTTGGTATAGTAGCTTGTTTCACCTAGAAATATT
AACCCAGCCTCCTTATAATAAAATCACAAAGTTATATCTGTTCCCCCTTGTCCCAGTGGAGGGTCAATAAATCACATGATGGCTTTGGCA

>6832_6832_3_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000393505_ANKFN1_chr17_54305278_ENST00000318698_length(amino acids)=822AA_BP=66
MLDAAGGGRGPGAGAAAAAGRAEEAEQGAGSGLARAPPAGWGFSSLGADAADLPATVADHGRQRDPRLLFKDRHFTCSKIIGRRFACFAQ
RLSHRRKQSQCDLLNESTGQLPTTCSSAASNSINWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFDEAYFRT
RTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSLESRA
MHLNTLVQEAQERVSELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPLSVNAAV
VTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQSEVLEGL
LQQVRALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSITQDFLWF
TKLSCMWEDIRWLRQSIPISSSSSTVLQTRQKMLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWMQISKLQ
SQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEWIQKLSG
SESMESVDHTSDCPMQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSGFLNLPL

--------------------------------------------------------------
>6832_6832_4_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000393505_ANKFN1_chr17_54305278_ENST00000566473_length(transcript)=4061nt_BP=242nt
ACCCCGCGCGGTTCCACGCCCCTGGCCGCGGCCCGGGCGCTGCGCTGCTCGACGCGGCGGGCGGCGGGCGGGGACCGGGGGCGGGGGCGG
CGGCGGCGGCCGGGAGAGCGGAGGAGGCGGAGCAGGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCC
TGGGCGCTGACGCCGCGGACCTCCCTGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGAGGCTACTCTTTAAAGACAGGCATTTTA
CTTGCAGCAAAATAATAGGAAGGAGATTCGCTTGCTTTGCACAGAGGCTGAGCCACAGGAGAAAGCAAAGCCAATGTGATTTATTGAATG
AAAGCACTGGACAATTACCAACAACTTGTTCCTCTGCTGCCTCGAACAGCATAAACTGGAATTGTCGTGTGAAAATGACGCAACAAATGC
AAAATTTACATCTCTGTCAGTCAAAAAAACATAGTGCTCCCTCATCTCCCAACGCAGCCAAACGCCTGTACAGGAACCTCTCTGAGAAAC
TGAAAGGGAGCCACTCTTCCTTCGATGAGGCCTATTTTAGGACAAGAACTGATCGGCTGAGTCTCAGGAAGACCTCGGTGAATTTCCAGG
GCAATGAAGCCATGTTTGAGGCAGTCGAACAGCAGGACATGGATGCTGTGCAGATCCTCCTGTATCAGTACACACCAGAAGAACTTGACC
TCAACACACCTAACAGCGAGGGCTTGACACCCCTGGATATTGCCATCATGACCAACAATGTGCCCATTGCAAGGATTCTTCTGAGGACAG
GGGCCCGAGAAAGTCCACACTTTGTCAGCCTGGAAAGCCGAGCAATGCACCTCAACACACTGGTCCAGGAAGCCCAGGAGAGGGTGAGTG
AACTGTCTGCCCAGGTGGAGAATGAAGGATTCACTCTGGACAACACAGAGAAAGAGAAGCAGCTGAAAGCTTGGGAGTGGAGGTATCGGC
TCTACAGACGCATGAAAACAGGCTTTGAGCATGCCAGAGCCCCTGAGATGCCAACCAATGTCTGTCTCATGGTAACCAGCAGCACATCAC
TCACTGTCAGCTTCCAAGAGCCTCTTAGCGTCAATGCAGCTGTAGTAACCAGGTATAAAGTGGAATGGAGTATGTCCGAAGACTTTTCTC
CTTTGGCTGGAGAAATCATCATGGATAATCTGCAGACTCTGAGATGCACAATCACAGGACTTACAATGGGCCAACAGTATTTTGTTCAAG
TCTCGGCTTACAATATGAAAGGATGGGGACCTGCTCAGACCACGACACCGGCATGTGCCTCTCCTTCTAACTGGAAAGACTATGACGACA
GAGAGCCCAGACACAAGGGACAGAGTGAAGTTTTGGAAGGTCTGCTGCAGCAGGTCCGAGCCCTTCATCAGCATTACAGTTGCCGGGAAA
GCACAAAATTACAAACCACAGGCCGCAAGCAGTCAGTCTCAAGAAGCCTGAAACACCTGTTCCATTCCTCGAACAAGTTTGTGAAGACCT
TAAAACGGGGACTCTACATAGCCGTTATATTTTATTACAAAGACAATATCTTAGTCACCAATGAAGATCAAGTACCAATTGTTGAAATAG
ATGACTCTCACACCAGTTCTATTACACAAGATTTTCTGTGGTTCACGAAGCTGTCTTGTATGTGGGAAGATATAAGGTGGCTGAGGCAAA
GCATACCAATATCCTCATCCTCATCCACAGTGCTGCAAACTCGGCAGAAGATGCTCGCAGCAACAGCACAGCTACAGAATTTACTTGGGA
CACACAACTTGGGAAGAGTTTACTATGAGCCCATTAAAGATCGACATGGAAACATACTCATAGTCACCATCAGGGAGGTGGAGATGCTTT
ATTCATTTTTTAATGGCAAATGGATGCAGATCTCAAAGCTGCAAAGCCAGAGAAAGTCTCTATCAACACCTGAGGAGCCAACAGCTTTAG
ACATTCTACTGATAACCATCCAGGATATTCTATCCTATCACAAAAGGAGTCATCAGCGTCTCTTTCCTGGATTATATCTGGGTTACCTAA
AGCTCTGTAGCTCTGTGGATCAAATCAAAGTTCTTGTTACCCAAAAGTTGCCCAACATTCTCTGCCACGTGAAGATCCGTGAAAACAATA
ATATTTCTAGAGAGGAATGGGAATGGATCCAAAAGCTTTCTGGCTCTGAATCTATGGAAAGTGTGGATCATACTTCTGACTGCCCCATGC
AATTGTTCTTCTACGAGCTCCAGATGGCAGTGAAAGCTCTCCTTCAGCAGATCAATATACCTCTACACCAGGCAAGGAACTTCCGCCTCT
ACACACAGGAGGTGTTGGAAATGGGTCACAATGTGTCCTTTCTTCTCCTGCTCCCTGCCTCAGACGACGTCTGTACAGCCCCAGGACAGA
ATAATCCTTACACCCCACACTCAGGGTTTCTTAACCTCCCTCTTCAGATGTTTGAACTTGTTCATTTTTGCAGCTACAGAGAGAAATTTA
TTAGTCTGTATTGCCGCCTTTCTGCTGTTGTGGAGCTGGATTCTCTGAACACCCAACAGTCCCTCAGGGAAGCAATCTCAGACAGCGAGG
TTGCAGCTGCCAAACAAAGACACCAGCAAGTTTTAGATTTCATTCAGCAAATAGATGAAGTCTGGCGTGAAATGAGATGGATCATGGATG
CTCTACAGTATGCAAGATACAAACAACCAGTTTCTGGCTTGCCCATCACTAAGCTGATAGACCCCTCAGATGAGCAGAGCCTAAAGAAGA
TCAATTCTACATCATCATCACATATAGACTGTCTTCCATCCCCACCCCCATCCCCAGAGATGCACAGAAGAAAGACAGTGAGTGATTCAC
AGCCCTGCTCTGATGAAGAAGCCTGCTCAGAAGTCTTCCTCCCCACCAACAGTGACTACGACTCCAGCGATGCCCTGAGCCCCAGAGACC
TGGACCTGGTCTACCTATCATCTCACGACATTGCGCAGCAGACCCTTAGCGGCCTAAGCGGCAGCGCCCCCGACGTCCTGCAAGTGCACG
ACGTGAAAACCCCTCTGGGGCCGGGCCAGGATCCCCAGGGCGAGGGCCCAAATCCCGATCACTCATGTGCCGAGTTTCTCCATAGCCTGA
CCCTCACGGGGTTCACACCCAAGAACCACGCCAAGACTGTGTCCGGTGGGCGGCCCCCGCTAGGCTTCCTGGGAAAGCGGAAGCCAGGCA
AGCACCCCCACTATGGCGGCTTCAGCCGCCATCATCGCTGGTTGCGCATCCACAGCGAGACCCAGTCGCTATCGCTCTCTGAGGGCATTT
ATACACAGCACCTGTCCCAGGCCTGTGGTCTGGCCCAGGAGCCCAAGGAGGCCAAGCGGGCCGGCCCTGCCCTTGATGATCCCAGGGGCC
TAACTCTGGCCCACGCTGCCAGCCTTCCTGAGGAGCGGAACAGCAGTCTCCAGGACGCGAGGCCTTCCGTCCGCCGCCTCTACGTGGAGC
CCTACGCAGCGGCCGTGGTGGCCCAGGACGAAAAACCATGGGCAAGCTTGAGCCCGCCCTCTGGAGGCCGCATCACCCTGCCCAGCCCCA
CTGGCCCCGATGTGAGTCAGGAGGGCCCCACCGCCTCTCCCATGTCAGAAATACTCAGCAGCATGCTTTAGGGAGGCCCATCCCGGCTGT
CCACCCCTCCATGGCTGCTACCTGCGTTTTACATCACCCTTACCCCCATCCTGCCCCACTGTGTACCCACTCATTTTCAAGCGTTTTGAA
TGTTATAAATACAAAGGTTACAAGTTCAAGGTCCTCTTTTTTTGGAACAGAGTGGTGGGTGGAGGCCAGAGTTGCCAGTGCCATTCCCAC
TTCAGCCTAGAAAGGGCATGGGGGAGTTGTGTCAACATGGAATACGACATACAGTGACTCAAACATGCCACCCTGTTGGTGGCACCTATG
ACTGAAGCTGGCCATCCCAAAGAGAGACCCTCTGTTCTGCAGCTGGTTCTGTAATCTGACCCCTAGTTTAGGGCTCTTTCATGAATTTGT

>6832_6832_4_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000393505_ANKFN1_chr17_54305278_ENST00000566473_length(amino acids)=1208AA_BP=66
MLDAAGGGRGPGAGAAAAAGRAEEAEQGAGSGLARAPPAGWGFSSLGADAADLPATVADHGRQRDPRLLFKDRHFTCSKIIGRRFACFAQ
RLSHRRKQSQCDLLNESTGQLPTTCSSAASNSINWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFDEAYFRT
RTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSLESRA
MHLNTLVQEAQERVSELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPLSVNAAV
VTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQSEVLEGL
LQQVRALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSITQDFLWF
TKLSCMWEDIRWLRQSIPISSSSSTVLQTRQKMLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWMQISKLQ
SQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEWIQKLSG
SESMESVDHTSDCPMQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSGFLNLPL
QMFELVHFCSYREKFISLYCRLSAVVELDSLNTQQSLREAISDSEVAAAKQRHQQVLDFIQQIDEVWREMRWIMDALQYARYKQPVSGLP
ITKLIDPSDEQSLKKINSTSSSHIDCLPSPPPSPEMHRRKTVSDSQPCSDEEACSEVFLPTNSDYDSSDALSPRDLDLVYLSSHDIAQQT
LSGLSGSAPDVLQVHDVKTPLGPGQDPQGEGPNPDHSCAEFLHSLTLTGFTPKNHAKTVSGGRPPLGFLGKRKPGKHPHYGGFSRHHRWL
RIHSETQSLSLSEGIYTQHLSQACGLAQEPKEAKRAGPALDDPRGLTLAHAASLPEERNSSLQDARPSVRRLYVEPYAAAVVAQDEKPWA

--------------------------------------------------------------
>6832_6832_5_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000420843_ANKFN1_chr17_54305278_ENST00000318698_length(transcript)=2488nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGAGGCTACTCTTTAAAGACAGGCATTTTACTTGCAGCAAAATAATAGGAAGGAGATTCGCTTG
CTTTGCACAGAGGCTGAGCCACAGGAGAAAGCAAAGCCAATGTGATTTATTGAATGAAAGCACTGGACAATTACCAACAACTTGTTCCTC
TGCTGCCTCGAACAGCATAAACTGGAATTGTCGTGTGAAAATGACGCAACAAATGCAAAATTTACATCTCTGTCAGTCAAAAAAACATAG
TGCTCCCTCATCTCCCAACGCAGCCAAACGCCTGTACAGGAACCTCTCTGAGAAACTGAAAGGGAGCCACTCTTCCTTCGATGAGGCCTA
TTTTAGGACAAGAACTGATCGGCTGAGTCTCAGGAAGACCTCGGTGAATTTCCAGGGCAATGAAGCCATGTTTGAGGCAGTCGAACAGCA
GGACATGGATGCTGTGCAGATCCTCCTGTATCAGTACACACCAGAAGAACTTGACCTCAACACACCTAACAGCGAGGGCTTGACACCCCT
GGATATTGCCATCATGACCAACAATGTGCCCATTGCAAGGATTCTTCTGAGGACAGGGGCCCGAGAAAGTCCACACTTTGTCAGCCTGGA
AAGCCGAGCAATGCACCTCAACACACTGGTCCAGGAAGCCCAGGAGAGGGTGAGTGAACTGTCTGCCCAGGTGGAGAATGAAGGATTCAC
TCTGGACAACACAGAGAAAGAGAAGCAGCTGAAAGCTTGGGAGTGGAGGTATCGGCTCTACAGACGCATGAAAACAGGCTTTGAGCATGC
CAGAGCCCCTGAGATGCCAACCAATGTCTGTCTCATGGTAACCAGCAGCACATCACTCACTGTCAGCTTCCAAGAGCCTCTTAGCGTCAA
TGCAGCTGTAGTAACCAGGTATAAAGTGGAATGGAGTATGTCCGAAGACTTTTCTCCTTTGGCTGGAGAAATCATCATGGATAATCTGCA
GACTCTGAGATGCACAATCACAGGACTTACAATGGGCCAACAGTATTTTGTTCAAGTCTCGGCTTACAATATGAAAGGATGGGGACCTGC
TCAGACCACGACACCGGCATGTGCCTCTCCTTCTAACTGGAAAGACTATGACGACAGAGAGCCCAGACACAAGGGACAGAGTGAAGTTTT
GGAAGGTCTGCTGCAGCAGGTCCGAGCCCTTCATCAGCATTACAGTTGCCGGGAAAGCACAAAATTACAAACCACAGGCCGCAAGCAGTC
AGTCTCAAGAAGCCTGAAACACCTGTTCCATTCCTCGAACAAGTTTGTGAAGACCTTAAAACGGGGACTCTACATAGCCGTTATATTTTA
TTACAAAGACAATATCTTAGTCACCAATGAAGATCAAGTACCAATTGTTGAAATAGATGACTCTCACACCAGTTCTATTACACAAGATTT
TCTGTGGTTCACGAAGCTGTCTTGTATGTGGGAAGATATAAGGTGGCTGAGGCAAAGCATACCAATATCCTCATCCTCATCCACAGTGCT
GCAAACTCGGCAGAAGATGCTCGCAGCAACAGCACAGCTACAGAATTTACTTGGGACACACAACTTGGGAAGAGTTTACTATGAGCCCAT
TAAAGATCGACATGGAAACATACTCATAGTCACCATCAGGGAGGTGGAGATGCTTTATTCATTTTTTAATGGCAAATGGATGCAGATCTC
AAAGCTGCAAAGCCAGAGAAAGTCTCTATCAACACCTGAGGAGCCAACAGCTTTAGACATTCTACTGATAACCATCCAGGATATTCTATC
CTATCACAAAAGGAGTCATCAGCGTCTCTTTCCTGGATTATATCTGGGTTACCTAAAGCTCTGTAGCTCTGTGGATCAAATCAAAGTTCT
TGTTACCCAAAAGTTGCCCAACATTCTCTGCCACGTGAAGATCCGTGAAAACAATAATATTTCTAGAGAGGAATGGGAATGGATCCAAAA
GCTTTCTGGCTCTGAATCTATGGAAAGTGTGGATCATACTTCTGACTGCCCCATGCAATTGTTCTTCTACGAGCTCCAGATGGCAGTGAA
AGCTCTCCTTCAGCAGATCAATATACCTCTACACCAGGCAAGGAACTTCCGCCTCTACACACAGGAGGTGTTGGAAATGGGTCACAATGT
GTCCTTTCTTCTCCTGCTCCCTGCCTCAGACGACGTCTGTACAGCCCCAGGACAGAATAATCCTTACACCCCACACTCAGGGTTTCTTAA
CCTCCCTCTTCAGATGTTTGAACTTGGTATAGTAGCTTGTTTCACCTAGAAATATTAACCCAGCCTCCTTATAATAAAATCACAAAGTTA

>6832_6832_5_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000420843_ANKFN1_chr17_54305278_ENST00000318698_length(amino acids)=790AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPRLLFKDRHFTCSKIIGRRFACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNS
INWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFDEAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAV
QILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSLESRAMHLNTLVQEAQERVSELSAQVENEGFTLDNTE
KEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCT
ITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQSEVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSL
KHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSITQDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQK
MLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWMQISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRS
HQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEWIQKLSGSESMESVDHTSDCPMQLFFYELQMAVKALLQQ

--------------------------------------------------------------
>6832_6832_6_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000420843_ANKFN1_chr17_54305278_ENST00000566473_length(transcript)=3937nt_BP=118nt
GGGAGCCGGGAGCGGGCTGGCCCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCCTGCGACCGT
CGCGGACCATGGGCGACAAAGGGACCCGAGGCTACTCTTTAAAGACAGGCATTTTACTTGCAGCAAAATAATAGGAAGGAGATTCGCTTG
CTTTGCACAGAGGCTGAGCCACAGGAGAAAGCAAAGCCAATGTGATTTATTGAATGAAAGCACTGGACAATTACCAACAACTTGTTCCTC
TGCTGCCTCGAACAGCATAAACTGGAATTGTCGTGTGAAAATGACGCAACAAATGCAAAATTTACATCTCTGTCAGTCAAAAAAACATAG
TGCTCCCTCATCTCCCAACGCAGCCAAACGCCTGTACAGGAACCTCTCTGAGAAACTGAAAGGGAGCCACTCTTCCTTCGATGAGGCCTA
TTTTAGGACAAGAACTGATCGGCTGAGTCTCAGGAAGACCTCGGTGAATTTCCAGGGCAATGAAGCCATGTTTGAGGCAGTCGAACAGCA
GGACATGGATGCTGTGCAGATCCTCCTGTATCAGTACACACCAGAAGAACTTGACCTCAACACACCTAACAGCGAGGGCTTGACACCCCT
GGATATTGCCATCATGACCAACAATGTGCCCATTGCAAGGATTCTTCTGAGGACAGGGGCCCGAGAAAGTCCACACTTTGTCAGCCTGGA
AAGCCGAGCAATGCACCTCAACACACTGGTCCAGGAAGCCCAGGAGAGGGTGAGTGAACTGTCTGCCCAGGTGGAGAATGAAGGATTCAC
TCTGGACAACACAGAGAAAGAGAAGCAGCTGAAAGCTTGGGAGTGGAGGTATCGGCTCTACAGACGCATGAAAACAGGCTTTGAGCATGC
CAGAGCCCCTGAGATGCCAACCAATGTCTGTCTCATGGTAACCAGCAGCACATCACTCACTGTCAGCTTCCAAGAGCCTCTTAGCGTCAA
TGCAGCTGTAGTAACCAGGTATAAAGTGGAATGGAGTATGTCCGAAGACTTTTCTCCTTTGGCTGGAGAAATCATCATGGATAATCTGCA
GACTCTGAGATGCACAATCACAGGACTTACAATGGGCCAACAGTATTTTGTTCAAGTCTCGGCTTACAATATGAAAGGATGGGGACCTGC
TCAGACCACGACACCGGCATGTGCCTCTCCTTCTAACTGGAAAGACTATGACGACAGAGAGCCCAGACACAAGGGACAGAGTGAAGTTTT
GGAAGGTCTGCTGCAGCAGGTCCGAGCCCTTCATCAGCATTACAGTTGCCGGGAAAGCACAAAATTACAAACCACAGGCCGCAAGCAGTC
AGTCTCAAGAAGCCTGAAACACCTGTTCCATTCCTCGAACAAGTTTGTGAAGACCTTAAAACGGGGACTCTACATAGCCGTTATATTTTA
TTACAAAGACAATATCTTAGTCACCAATGAAGATCAAGTACCAATTGTTGAAATAGATGACTCTCACACCAGTTCTATTACACAAGATTT
TCTGTGGTTCACGAAGCTGTCTTGTATGTGGGAAGATATAAGGTGGCTGAGGCAAAGCATACCAATATCCTCATCCTCATCCACAGTGCT
GCAAACTCGGCAGAAGATGCTCGCAGCAACAGCACAGCTACAGAATTTACTTGGGACACACAACTTGGGAAGAGTTTACTATGAGCCCAT
TAAAGATCGACATGGAAACATACTCATAGTCACCATCAGGGAGGTGGAGATGCTTTATTCATTTTTTAATGGCAAATGGATGCAGATCTC
AAAGCTGCAAAGCCAGAGAAAGTCTCTATCAACACCTGAGGAGCCAACAGCTTTAGACATTCTACTGATAACCATCCAGGATATTCTATC
CTATCACAAAAGGAGTCATCAGCGTCTCTTTCCTGGATTATATCTGGGTTACCTAAAGCTCTGTAGCTCTGTGGATCAAATCAAAGTTCT
TGTTACCCAAAAGTTGCCCAACATTCTCTGCCACGTGAAGATCCGTGAAAACAATAATATTTCTAGAGAGGAATGGGAATGGATCCAAAA
GCTTTCTGGCTCTGAATCTATGGAAAGTGTGGATCATACTTCTGACTGCCCCATGCAATTGTTCTTCTACGAGCTCCAGATGGCAGTGAA
AGCTCTCCTTCAGCAGATCAATATACCTCTACACCAGGCAAGGAACTTCCGCCTCTACACACAGGAGGTGTTGGAAATGGGTCACAATGT
GTCCTTTCTTCTCCTGCTCCCTGCCTCAGACGACGTCTGTACAGCCCCAGGACAGAATAATCCTTACACCCCACACTCAGGGTTTCTTAA
CCTCCCTCTTCAGATGTTTGAACTTGTTCATTTTTGCAGCTACAGAGAGAAATTTATTAGTCTGTATTGCCGCCTTTCTGCTGTTGTGGA
GCTGGATTCTCTGAACACCCAACAGTCCCTCAGGGAAGCAATCTCAGACAGCGAGGTTGCAGCTGCCAAACAAAGACACCAGCAAGTTTT
AGATTTCATTCAGCAAATAGATGAAGTCTGGCGTGAAATGAGATGGATCATGGATGCTCTACAGTATGCAAGATACAAACAACCAGTTTC
TGGCTTGCCCATCACTAAGCTGATAGACCCCTCAGATGAGCAGAGCCTAAAGAAGATCAATTCTACATCATCATCACATATAGACTGTCT
TCCATCCCCACCCCCATCCCCAGAGATGCACAGAAGAAAGACAGTGAGTGATTCACAGCCCTGCTCTGATGAAGAAGCCTGCTCAGAAGT
CTTCCTCCCCACCAACAGTGACTACGACTCCAGCGATGCCCTGAGCCCCAGAGACCTGGACCTGGTCTACCTATCATCTCACGACATTGC
GCAGCAGACCCTTAGCGGCCTAAGCGGCAGCGCCCCCGACGTCCTGCAAGTGCACGACGTGAAAACCCCTCTGGGGCCGGGCCAGGATCC
CCAGGGCGAGGGCCCAAATCCCGATCACTCATGTGCCGAGTTTCTCCATAGCCTGACCCTCACGGGGTTCACACCCAAGAACCACGCCAA
GACTGTGTCCGGTGGGCGGCCCCCGCTAGGCTTCCTGGGAAAGCGGAAGCCAGGCAAGCACCCCCACTATGGCGGCTTCAGCCGCCATCA
TCGCTGGTTGCGCATCCACAGCGAGACCCAGTCGCTATCGCTCTCTGAGGGCATTTATACACAGCACCTGTCCCAGGCCTGTGGTCTGGC
CCAGGAGCCCAAGGAGGCCAAGCGGGCCGGCCCTGCCCTTGATGATCCCAGGGGCCTAACTCTGGCCCACGCTGCCAGCCTTCCTGAGGA
GCGGAACAGCAGTCTCCAGGACGCGAGGCCTTCCGTCCGCCGCCTCTACGTGGAGCCCTACGCAGCGGCCGTGGTGGCCCAGGACGAAAA
ACCATGGGCAAGCTTGAGCCCGCCCTCTGGAGGCCGCATCACCCTGCCCAGCCCCACTGGCCCCGATGTGAGTCAGGAGGGCCCCACCGC
CTCTCCCATGTCAGAAATACTCAGCAGCATGCTTTAGGGAGGCCCATCCCGGCTGTCCACCCCTCCATGGCTGCTACCTGCGTTTTACAT
CACCCTTACCCCCATCCTGCCCCACTGTGTACCCACTCATTTTCAAGCGTTTTGAATGTTATAAATACAAAGGTTACAAGTTCAAGGTCC
TCTTTTTTTGGAACAGAGTGGTGGGTGGAGGCCAGAGTTGCCAGTGCCATTCCCACTTCAGCCTAGAAAGGGCATGGGGGAGTTGTGTCA
ACATGGAATACGACATACAGTGACTCAAACATGCCACCCTGTTGGTGGCACCTATGACTGAAGCTGGCCATCCCAAAGAGAGACCCTCTG

>6832_6832_6_ARRB1-ANKFN1_ARRB1_chr11_75062632_ENST00000420843_ANKFN1_chr17_54305278_ENST00000566473_length(amino acids)=1176AA_BP=34
MARAPPAGWGFSSLGADAADLPATVADHGRQRDPRLLFKDRHFTCSKIIGRRFACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNS
INWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFDEAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAV
QILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSLESRAMHLNTLVQEAQERVSELSAQVENEGFTLDNTE
KEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCT
ITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQSEVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSL
KHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSITQDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQK
MLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWMQISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRS
HQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEWIQKLSGSESMESVDHTSDCPMQLFFYELQMAVKALLQQ
INIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSGFLNLPLQMFELVHFCSYREKFISLYCRLSAVVELDSLN
TQQSLREAISDSEVAAAKQRHQQVLDFIQQIDEVWREMRWIMDALQYARYKQPVSGLPITKLIDPSDEQSLKKINSTSSSHIDCLPSPPP
SPEMHRRKTVSDSQPCSDEEACSEVFLPTNSDYDSSDALSPRDLDLVYLSSHDIAQQTLSGLSGSAPDVLQVHDVKTPLGPGQDPQGEGP
NPDHSCAEFLHSLTLTGFTPKNHAKTVSGGRPPLGFLGKRKPGKHPHYGGFSRHHRWLRIHSETQSLSLSEGIYTQHLSQACGLAQEPKE
AKRAGPALDDPRGLTLAHAASLPEERNSSLQDARPSVRRLYVEPYAAAVVAQDEKPWASLSPPSGGRITLPSPTGPDVSQEGPTASPMSE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARRB1-ANKFN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARRB1chr11:75062632chr17:54305278ENST00000360025-11545_866.666666666666667411.0CHRM2
HgeneARRB1chr11:75062632chr17:54305278ENST00000420843-11645_866.666666666666667419.0CHRM2
HgeneARRB1chr11:75062632chr17:54305278ENST00000360025-1151_1636.666666666666667411.0SRC
HgeneARRB1chr11:75062632chr17:54305278ENST00000420843-1161_1636.666666666666667419.0SRC
HgeneARRB1chr11:75062632chr17:54305278ENST00000360025-115318_4186.666666666666667411.0TRAF6
HgeneARRB1chr11:75062632chr17:54305278ENST00000420843-116318_4186.666666666666667419.0TRAF6


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARRB1-ANKFN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARRB1-ANKFN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARRB1C0023890Liver Cirrhosis1CTD_human
HgeneARRB1C0041696Unipolar Depression1PSYGENET
HgeneARRB1C0239946Fibrosis, Liver1CTD_human
HgeneARRB1C1269683Major Depressive Disorder1PSYGENET
HgeneARRB1C3178803Social Anhedonia1PSYGENET