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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HCG17-OCIAD1 (FusionGDB2 ID:HG414778TG54940)

Fusion Gene Summary for HCG17-OCIAD1

check button Fusion gene summary
Fusion gene informationFusion gene name: HCG17-OCIAD1
Fusion gene ID: hg414778tg54940
HgeneTgene
Gene symbol

HCG17

OCIAD1

Gene ID

414778

54940

Gene nameHLA complex group 17OCIA domain containing 1
SynonymsHCG18|LINC00046|NCRNA00046ASRIJ|OCIA|TPA018
Cytomap('HCG17')('OCIAD1')

6p22.1

4p11

Type of genencRNAprotein-coding
DescriptionHLA complex group 17 (non-protein coding)long intergenic non-protein coding RNA 46OCIA domain-containing protein 1ovarian cancer immunoreactive antigen domain containing 1ovarian cancer immunoreactive antigen domain containing 1Aovarian carcinoma immunoreactive antigen
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000426984, ENST00000419861, 
ENST00000437311, ENST00000439480, 
ENST00000448760, ENST00000453558, 
ENST00000455160, 
Fusion gene scores* DoF score4 X 4 X 3=4812 X 11 X 7=924
# samples 414
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/924*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HCG17 [Title/Abstract] AND OCIAD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHCG17(1587434)-OCIAD1(48859230), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-AK-3445-01AHCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+


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Fusion Gene ORF analysis for HCG17-OCIAD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000426984ENST00000509122HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
5UTR-intronENST00000426984ENST00000264312HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
5UTR-intronENST00000426984ENST00000381473HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
5UTR-intronENST00000426984ENST00000396448HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
5UTR-intronENST00000426984ENST00000425583HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
5UTR-intronENST00000426984ENST00000444354HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
5UTR-intronENST00000426984ENST00000506801HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
5UTR-intronENST00000426984ENST00000508293HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
5UTR-intronENST00000426984ENST00000512981HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
5UTR-intronENST00000426984ENST00000513391HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-3CDSENST00000419861ENST00000509122HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-3CDSENST00000437311ENST00000509122HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-3CDSENST00000439480ENST00000509122HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-3CDSENST00000448760ENST00000509122HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-3CDSENST00000453558ENST00000509122HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-3CDSENST00000455160ENST00000509122HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000419861ENST00000264312HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000419861ENST00000381473HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000419861ENST00000396448HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000419861ENST00000425583HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000419861ENST00000444354HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000419861ENST00000506801HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000419861ENST00000508293HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000419861ENST00000512981HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000419861ENST00000513391HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000437311ENST00000264312HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000437311ENST00000381473HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000437311ENST00000396448HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000437311ENST00000425583HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000437311ENST00000444354HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000437311ENST00000506801HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000437311ENST00000508293HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000437311ENST00000512981HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000437311ENST00000513391HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000439480ENST00000264312HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000439480ENST00000381473HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000439480ENST00000396448HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000439480ENST00000425583HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000439480ENST00000444354HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000439480ENST00000506801HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000439480ENST00000508293HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000439480ENST00000512981HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000439480ENST00000513391HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000448760ENST00000264312HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000448760ENST00000381473HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000448760ENST00000396448HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000448760ENST00000425583HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000448760ENST00000444354HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000448760ENST00000506801HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000448760ENST00000508293HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000448760ENST00000512981HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000448760ENST00000513391HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000453558ENST00000264312HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000453558ENST00000381473HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000453558ENST00000396448HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000453558ENST00000425583HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000453558ENST00000444354HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000453558ENST00000506801HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000453558ENST00000508293HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000453558ENST00000512981HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000453558ENST00000513391HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000455160ENST00000264312HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000455160ENST00000381473HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000455160ENST00000396448HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000455160ENST00000425583HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000455160ENST00000444354HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000455160ENST00000506801HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000455160ENST00000508293HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000455160ENST00000512981HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+
intron-intronENST00000455160ENST00000513391HCG17chr6_dbb_hap3

1587434

-OCIAD1chr4

48859230

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HCG17-OCIAD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HCG17chr6_dbb_hap31587433-OCIAD1chr448859229+2.03E-060.999998
HCG17chr6_dbb_hap31587433-OCIAD1chr448859229+2.03E-060.999998


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HCG17-OCIAD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1587434/:48859230)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HCG17-OCIAD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HCG17-OCIAD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HCG17-OCIAD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HCG17-OCIAD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human