Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:HCG17-TRIM26 (FusionGDB2 ID:HG414778TG7726)

Fusion Gene Summary for HCG17-TRIM26

check button Fusion gene summary
Fusion gene informationFusion gene name: HCG17-TRIM26
Fusion gene ID: hg414778tg7726
HgeneTgene
Gene symbol

HCG17

TRIM26

Gene ID

414778

7726

Gene nameHLA complex group 17tripartite motif containing 26
SynonymsHCG18|LINC00046|NCRNA00046AFP|RNF95|ZNF173
Cytomap('HCG17')('TRIM26')

6p22.1

6p22.1

Type of genencRNAprotein-coding
DescriptionHLA complex group 17 (non-protein coding)long intergenic non-protein coding RNA 46tripartite motif-containing protein 26RING finger protein 95acid finger proteinwidely expressed acid zinc finger proteinzinc finger protein 173
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000453558, ENST00000419861, 
ENST00000426984, ENST00000437311, 
ENST00000439480, ENST00000448760, 
ENST00000455160, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 5 X 5=125
# samples 48
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/125*10)=-0.643856189774725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HCG17 [Title/Abstract] AND TRIM26 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHCG17(30293786)-TRIM26(30172542), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM26

GO:0045087

innate immune response

18248090

TgeneTRIM26

GO:0046597

negative regulation of viral entry into host cell

18248090

TgeneTRIM26

GO:0051091

positive regulation of DNA-binding transcription factor activity

23077300

TgeneTRIM26

GO:1902187

negative regulation of viral release from host cell

18248090



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J5-01AHCG17chr6

30293786

-TRIM26chr6

30172542

-


Top

Fusion Gene ORF analysis for HCG17-TRIM26

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000453558ENST00000437089HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-5UTRENST00000453558ENST00000454678HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-5UTRENST00000453558ENST00000487829HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000327357HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000383607HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000396558HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000415923HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000422349HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000425523HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000425831HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000427535HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000428486HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000432326HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000433314HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000436219HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000438384HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000438908HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000439094HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000445259HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000447711HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000450392HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000453195HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000455000HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000456093HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000456770HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000463977HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000475230HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000477353HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000477569HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000481596HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000484938HCG17chr6

30293786

-TRIM26chr6

30172542

-
5UTR-intronENST00000453558ENST00000486529HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-3CDSENST00000419861ENST00000437089HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-3CDSENST00000426984ENST00000437089HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-3CDSENST00000437311ENST00000437089HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-3CDSENST00000439480ENST00000437089HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-3CDSENST00000448760ENST00000437089HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-3CDSENST00000455160ENST00000437089HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000419861ENST00000454678HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000419861ENST00000487829HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000426984ENST00000454678HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000426984ENST00000487829HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000437311ENST00000454678HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000437311ENST00000487829HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000439480ENST00000454678HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000439480ENST00000487829HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000448760ENST00000454678HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000448760ENST00000487829HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000455160ENST00000454678HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-5UTRENST00000455160ENST00000487829HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000327357HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000383607HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000396558HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000415923HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000422349HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000425523HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000425831HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000427535HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000428486HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000432326HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000433314HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000436219HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000438384HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000438908HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000439094HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000445259HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000447711HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000450392HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000453195HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000455000HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000456093HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000456770HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000463977HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000475230HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000477353HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000477569HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000481596HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000484938HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000419861ENST00000486529HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000327357HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000383607HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000396558HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000415923HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000422349HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000425523HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000425831HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000427535HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000428486HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000432326HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000433314HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000436219HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000438384HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000438908HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000439094HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000445259HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000447711HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000450392HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000453195HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000455000HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000456093HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000456770HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000463977HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000475230HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000477353HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000477569HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000481596HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000484938HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000426984ENST00000486529HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000327357HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000383607HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000396558HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000415923HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000422349HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000425523HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000425831HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000427535HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000428486HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000432326HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000433314HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000436219HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000438384HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000438908HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000439094HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000445259HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000447711HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000450392HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000453195HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000455000HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000456093HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000456770HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000463977HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000475230HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000477353HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000477569HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000481596HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000484938HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000437311ENST00000486529HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000327357HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000383607HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000396558HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000415923HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000422349HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000425523HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000425831HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000427535HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000428486HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000432326HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000433314HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000436219HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000438384HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000438908HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000439094HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000445259HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000447711HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000450392HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000453195HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000455000HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000456093HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000456770HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000463977HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000475230HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000477353HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000477569HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000481596HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000484938HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000439480ENST00000486529HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000327357HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000383607HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000396558HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000415923HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000422349HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000425523HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000425831HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000427535HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000428486HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000432326HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000433314HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000436219HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000438384HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000438908HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000439094HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000445259HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000447711HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000450392HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000453195HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000455000HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000456093HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000456770HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000463977HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000475230HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000477353HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000477569HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000481596HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000484938HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000448760ENST00000486529HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000327357HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000383607HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000396558HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000415923HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000422349HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000425523HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000425831HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000427535HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000428486HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000432326HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000433314HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000436219HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000438384HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000438908HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000439094HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000445259HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000447711HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000450392HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000453195HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000455000HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000456093HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000456770HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000463977HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000475230HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000477353HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000477569HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000481596HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000484938HCG17chr6

30293786

-TRIM26chr6

30172542

-
intron-intronENST00000455160ENST00000486529HCG17chr6

30293786

-TRIM26chr6

30172542

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for HCG17-TRIM26


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for HCG17-TRIM26


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30293786/:30172542)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for HCG17-TRIM26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for HCG17-TRIM26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for HCG17-TRIM26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for HCG17-TRIM26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource