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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MBP-ARF1 (FusionGDB2 ID:HG4155TG375)

Fusion Gene Summary for MBP-ARF1

check button Fusion gene summary
Fusion gene informationFusion gene name: MBP-ARF1
Fusion gene ID: hg4155tg375
HgeneTgene
Gene symbol

MBP

ARF1

Gene ID

4155

375

Gene namemyelin basic proteinADP ribosylation factor 1
Synonyms-PVNH8
Cytomap('MBP')('ARF1')

18q23

1q42.13

Type of geneprotein-codingprotein-coding
Descriptionmyelin basic proteinGolli-MBPproline-rich proteoglycan 2myelin A1 proteinmyelin membrane encephalitogenic proteinADP-ribosylation factor 1
Modification date2020031320200322
UniProtAcc

P02686

P84077

Ensembl transtripts involved in fusion geneENST00000355994, ENST00000397860, 
ENST00000487778, ENST00000579129, 
ENST00000354542, ENST00000359645, 
ENST00000382582, ENST00000397863, 
ENST00000397865, ENST00000397866, 
ENST00000397869, ENST00000397875, 
ENST00000526111, ENST00000527041, 
ENST00000528160, ENST00000578193, 
ENST00000580402, 
Fusion gene scores* DoF score26 X 20 X 7=36409 X 10 X 6=540
# samples 2611
** MAII scorelog2(26/3640*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBP [Title/Abstract] AND ARF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMBP(74844536)-ARF1(228284779), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMBP

GO:0000165

MAPK cascade

22524708

HgeneMBP

GO:0034115

negative regulation of heterotypic cell-cell adhesion

22524708

HgeneMBP

GO:0035633

maintenance of permeability of blood-brain barrier

22524708

HgeneMBP

GO:1904209

positive regulation of chemokine (C-C motif) ligand 2 secretion

22524708

HgeneMBP

GO:1904685

positive regulation of metalloendopeptidase activity

22524708

HgeneMBP

GO:2000778

positive regulation of interleukin-6 secretion

22524708



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-MY-A5BF-01AMBPchr18

74844536

-ARF1chr1

228284779

+


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Fusion Gene ORF analysis for MBP-ARF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000355994ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-3UTRENST00000397860ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-3UTRENST00000487778ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-3UTRENST00000579129ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000355994ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000355994ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000355994ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000397860ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000397860ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000397860ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000487778ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000487778ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000487778ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000579129ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000579129ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
5UTR-5UTRENST00000579129ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000354542ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000359645ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000382582ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000397863ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000397865ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000397866ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000397869ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000397875ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000526111ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000527041ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000528160ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000578193ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-3UTRENST00000580402ENST00000478424MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000354542ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000354542ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000354542ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000359645ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000359645ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000359645ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000382582ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000382582ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000382582ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397863ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397863ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397863ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397865ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397865ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397865ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397866ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397866ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397866ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397869ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397869ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397869ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397875ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397875ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000397875ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000526111ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000526111ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000526111ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000527041ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000527041ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000527041ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000528160ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000528160ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000528160ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000578193ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000578193ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000578193ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000580402ENST00000272102MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000580402ENST00000540651MBPchr18

74844536

-ARF1chr1

228284779

+
intron-5UTRENST00000580402ENST00000541182MBPchr18

74844536

-ARF1chr1

228284779

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MBP-ARF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MBP-ARF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:74844536/:228284779)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBP

P02686

ARF1

P84077

FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}.FUNCTION: GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MBP-ARF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MBP-ARF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MBP-ARF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneARF1P84077DB09462GlycerinSmall moleculeApproved|Investigational

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Related Diseases for MBP-ARF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMBPC0036341Schizophrenia4PSYGENET
HgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
HgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneMBPC0011303Demyelinating Diseases1CTD_human
HgeneMBPC0011304Demyelination1CTD_human
HgeneMBPC0027873Neuromyelitis Optica1CTD_human
HgeneMBPC2350037Clinically Isolated Syndrome, CNS Demyelinating1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1868720Periventricular Nodular Heterotopia1ORPHANET
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4748602PERIVENTRICULAR NODULAR HETEROTOPIA 81UNIPROT