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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MBP-PTPN2 (FusionGDB2 ID:HG4155TG5771)

Fusion Gene Summary for MBP-PTPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: MBP-PTPN2
Fusion gene ID: hg4155tg5771
HgeneTgene
Gene symbol

MBP

PTPN2

Gene ID

4155

5771

Gene namemyelin basic proteinprotein tyrosine phosphatase non-receptor type 2
Synonyms-PTN2|PTPT|TC-PTP|TCELLPTP|TCPTP
Cytomap('MBP')('PTPN2')

18q23

18p11.21

Type of geneprotein-codingprotein-coding
Descriptionmyelin basic proteinGolli-MBPproline-rich proteoglycan 2myelin A1 proteinmyelin membrane encephalitogenic proteintyrosine-protein phosphatase non-receptor type 2T-cell protein tyrosine phosphatase
Modification date2020031320200329
UniProtAcc

P02686

.
Ensembl transtripts involved in fusion geneENST00000355994, ENST00000397860, 
ENST00000397863, ENST00000579129, 
ENST00000580402, ENST00000487778, 
ENST00000354542, ENST00000359645, 
ENST00000382582, ENST00000397865, 
ENST00000397866, ENST00000397869, 
ENST00000397875, ENST00000526111, 
ENST00000527041, ENST00000528160, 
ENST00000578193, 
Fusion gene scores* DoF score26 X 20 X 7=36408 X 9 X 5=360
# samples 269
** MAII scorelog2(26/3640*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MBP [Title/Abstract] AND PTPN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMBP(74817167)-PTPN2(12802150), # samples:1
Anticipated loss of major functional domain due to fusion event.MBP-PTPN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MBP-PTPN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MBP-PTPN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MBP-PTPN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MBP-PTPN2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMBP

GO:0000165

MAPK cascade

22524708

HgeneMBP

GO:0034115

negative regulation of heterotypic cell-cell adhesion

22524708

HgeneMBP

GO:0035633

maintenance of permeability of blood-brain barrier

22524708

HgeneMBP

GO:1904209

positive regulation of chemokine (C-C motif) ligand 2 secretion

22524708

HgeneMBP

GO:1904685

positive regulation of metalloendopeptidase activity

22524708

HgeneMBP

GO:2000778

positive regulation of interleukin-6 secretion

22524708


check buttonFusion gene breakpoints across MBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PTPN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8364-01AMBPchr18

74817167

-PTPN2chr18

12802150

-


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Fusion Gene ORF analysis for MBP-PTPN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355994ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
5CDS-intronENST00000355994ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
5CDS-intronENST00000397860ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
5CDS-intronENST00000397860ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
5CDS-intronENST00000397863ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
5CDS-intronENST00000397863ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
5CDS-intronENST00000579129ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
5CDS-intronENST00000579129ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
5CDS-intronENST00000580402ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
5CDS-intronENST00000580402ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
5UTR-3CDSENST00000487778ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
5UTR-3CDSENST00000487778ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
5UTR-3CDSENST00000487778ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
5UTR-3CDSENST00000487778ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
5UTR-intronENST00000487778ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
5UTR-intronENST00000487778ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000355994ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000355994ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000355994ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000355994ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000397860ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000397860ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000397860ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000397860ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000397863ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000397863ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000397863ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000397863ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000579129ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000579129ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000579129ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
Frame-shiftENST00000579129ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
In-frameENST00000580402ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
In-frameENST00000580402ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
In-frameENST00000580402ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
In-frameENST00000580402ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000354542ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000354542ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000354542ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000354542ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000359645ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000359645ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000359645ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000359645ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000382582ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000382582ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000382582ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000382582ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397865ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397865ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397865ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397865ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397866ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397866ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397866ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397866ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397869ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397869ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397869ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397869ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397875ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397875ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397875ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000397875ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000526111ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000526111ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000526111ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000526111ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000527041ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000527041ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000527041ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000527041ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000528160ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000528160ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000528160ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000528160ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000578193ENST00000309660MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000578193ENST00000327283MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000578193ENST00000353319MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-3CDSENST00000578193ENST00000591115MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000354542ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000354542ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000359645ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000359645ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000382582ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000382582ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000397865ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000397865ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000397866ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000397866ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000397869ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000397869ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000397875ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000397875ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000526111ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000526111ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000527041ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000527041ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000528160ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000528160ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000578193ENST00000589086MBPchr18

74817167

-PTPN2chr18

12802150

-
intron-intronENST00000578193ENST00000591497MBPchr18

74817167

-PTPN2chr18

12802150

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000580402MBPchr1874817167-ENST00000327283PTPN2chr1812802150-702510356118
ENST00000580402MBPchr1874817167-ENST00000591115PTPN2chr1812802150-699510356118
ENST00000580402MBPchr1874817167-ENST00000353319PTPN2chr1812802150-59551025484
ENST00000580402MBPchr1874817167-ENST00000309660PTPN2chr1812802150-2566510440146

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000580402ENST00000327283MBPchr1874817167-PTPN2chr1812802150-0.0274242440.9725758
ENST00000580402ENST00000591115MBPchr1874817167-PTPN2chr1812802150-0.0279640540.97203594
ENST00000580402ENST00000353319MBPchr1874817167-PTPN2chr1812802150-0.0438678080.95613223
ENST00000580402ENST00000309660MBPchr1874817167-PTPN2chr1812802150-0.0104511050.9895489

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Fusion Genomic Features for MBP-PTPN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for MBP-PTPN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:74817167/chr18:12802150)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBP

P02686

.
FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPN2chr18:74817167chr18:12802150ENST0000030966069346_415286416.0RegionNote=Endoplasmic reticulum location
TgenePTPN2chr18:74817167chr18:12802150ENST00000327283610346_415286388.0RegionNote=Endoplasmic reticulum location
TgenePTPN2chr18:74817167chr18:12802150ENST0000035331969346_415286354.0RegionNote=Endoplasmic reticulum location

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBPchr18:74817167chr18:12802150ENST00000355994-29179_22217305.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:12802150ENST00000355994-29246_25617305.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:12802150ENST00000359645-16179_2220187.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:12802150ENST00000359645-16246_2560187.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:12802150ENST00000382582-17179_2220198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:12802150ENST00000382582-17246_2560198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:12802150ENST00000397860-24179_22217198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:12802150ENST00000397860-24246_25617198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:12802150ENST00000397863-24179_22217198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:12802150ENST00000397863-24246_25617198.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:12802150ENST00000397865-15179_2220161.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:12802150ENST00000397865-15246_2560161.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:12802150ENST00000397866-16179_2220172.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:12802150ENST00000397866-16246_2560172.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
HgeneMBPchr18:74817167chr18:12802150ENST00000580402-18179_22217305.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 1
HgeneMBPchr18:74817167chr18:12802150ENST00000580402-18246_25617305.0RegionNote=Induces experimental autoimmune encephalomyelitis (EAE) 2
TgenePTPN2chr18:74817167chr18:12802150ENST00000309660695_275286416.0DomainTyrosine-protein phosphatase
TgenePTPN2chr18:74817167chr18:12802150ENST000003272836105_275286388.0DomainTyrosine-protein phosphatase
TgenePTPN2chr18:74817167chr18:12802150ENST00000353319695_275286354.0DomainTyrosine-protein phosphatase
TgenePTPN2chr18:74817167chr18:12802150ENST0000030966069216_222286416.0RegionSubstrate binding
TgenePTPN2chr18:74817167chr18:12802150ENST00000327283610216_222286388.0RegionSubstrate binding
TgenePTPN2chr18:74817167chr18:12802150ENST0000035331969216_222286354.0RegionSubstrate binding


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Fusion Gene Sequence for MBP-PTPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>52079_52079_1_MBP-PTPN2_MBP_chr18_74817167_ENST00000580402_PTPN2_chr18_12802150_ENST00000309660_length(transcript)=2566nt_BP=51nt
ATGGGAAACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGAAACGATGGAAAGAACTTTCTAAGGAAGACTTATCTCCT
GCCTTTGATCATTCACCAAACAAAATAATGACTGAAAAATACAATGGGAACAGAATAGGTCTAGAAGAAGAAAAACTGACAGGTGACCGA
TGTACAGGACTTTCCTCTAAAATGCAAGATACAATGGAGGAGAACAGTGAGAGTGCTCTACGGAAACGTATTCGAGAGGACAGAAAGGCC
ACCACAGCTCAGAAGGTGCAGCAGATGAAACAGAGGCTAAATGAGAATGAACGAAAAAGAAAAAGGTGGTTATATTGGCAACCTATTCTC
ACTAAGATGGGGTTTATGTCAGTCATTTTGGTTGGCGCTTTTGTTGGCTGGACACTGTTTTTTCAGCAAAATGCCCTATAAACAATTAAT
TTTGCCCAGCAAGCTTCTGCACTAGTAACTGACAGTGCTACATTAATCATAGGGGTTTGTCTGCAGCAAACGCCTCATATCCCAAAAACG
GTGCAGTAGAATAGACATCAACCAGATAAGTGATATTTACAGTCACAAGCCCAACATCTCAGGACTCTTGACTGCAGGTTCCTCTGAACC
CCAAACTGTAAATGGCTGTCTAAAATAAAGACATTCATGTTTGTTAAAAACTGGTAAATTTTGCAACTGTATTCATACATGTCAAACACA
GTATTTCACCTGACCAACATTGAGATATCCTTTATCACAGGATTTGTTTTTGGAGGCTATCTGGATTTTAACCTGCACTTGATATAAGCA
ATAAATATTGTGGTTTTATCTACGTTATTGGAAAGAAAATGACATTTAAATAATGTGTGTAATGTATAATGTACTATTGACATGGGCATC
AACACTTTTATTCTTAAGCATTTCAGGGTAAATATATTTTATAAGTATCTATTTAATCTTTTGTAGTTAACTGTACTTTTTAAGAGCTCA
ATTTGAAAAATCTGTTACTAAAAAAATAAATTGTATGTCGATTGAATTGTACTGGATACATTTTCCATTTTTCTAAAGAGAAGTTTGATA
TGAGCAGTTAGAAGTTGGAATAAGCAATTTCTACTATATATTGCATTTCTTTTATGTTTTACAGTTTTCCCCATTTTAAAAAGAAAAGCA
AACAAAGAAACAAAAGTTTTTCCTAAAAATATCTTTGAAGGAAAATTCTCCTTACTGGGATAGTCAGGTAAACAGTTGGTCAAGACTTTG
TAAAGAAATTGGTTTCTGTAAATCCCATTATTGATATGTTTATTTTTCATGAAAATTTCAATGTAGTTGGGGTAGATTATGATTTAGGAA
GCAAAAGTAAGAAGCAGCATTTTATGATTCATAATTTCAGTTTACTAGACTGAAGTTTTGAAGTAAACACTTTTCAGTTTCTTTCTACTT
CAATAAATAGTATGATTATATGCAAACCTTACATTGTCATTTTAACTTAATGAATATTTTTTAAAGCAAACTGTTTAATGAATTTAACTG
CTCATTTGAATGCTAGCTTTCCTCAGATTTCAACATTCCATTCAGTGTTTAATTTGTCTTACTTAAACTTGAAATTGTTGTTACAAATTT
AATTGCTAGGAGGCATGGATAGCATACATTATTATGGATAGCATACCTTATTTCAGTGGTTTTCAAACTATGCTCATTGGATGTCCAGGT
GGGTCAAGAGGTTACTTTCAACCACAGCATCTCTGCCTTGTCTCTTTATATGCCACATAAGATTTCTGCATAAGGCTTAAGTATTTTAAA
GGGGGCAGTTATCATTTAAAAACAGTTTGGTCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATC
ACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACGTGGTGAAACACCATCTCTACTAAAAATGCAAAAATTAGCTGGGCATGGTGGAG
GGCACCTGTAATCTCAGCTACTCAGGAGGCTGAGGTAGGAGAATTGCTTGAACCCAGGAGATGGAGGTTGCAGTGAGCTGAGATCACGTC
ACTGCACTCCAGCCAGGGCGACAGAGCGAGACTCCATCTCAAAAGAAACAAACAAAAAAAACAGTTTGGGCCGGGTGTGGTGGCTCACGC
TTGTAATCCCAGCACTTCGGAAGGCCAAGGCGGGCGGATCACGAGGTCAAGAGATGGAGACTGTCCTGGCCAACATGGTGAAATCCCTTC
TTTACTAAAAATACAAAAATTATCTGGGCGTGGTGGTGCATGCCTGTAGTCCCAGCTCCTTGGGAGGCTAAGGCAGGAGAATCACTTGAA
CCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGCAACAGAGCAAGACTTCGTCTCAAAAAAAAAAAAA
AAAAAAGTTTGAAAACCATTGGTATAGATAGATATTTTGAATTGATTTGCATAGTCTCCTTGAATGTGTTAAATTATGTTGAAAGTATGA
AAGCAGGATGTAGGTGGTACTACATATTAAATAAGATTTATATAAC

>52079_52079_1_MBP-PTPN2_MBP_chr18_74817167_ENST00000580402_PTPN2_chr18_12802150_ENST00000309660_length(amino acids)=146AA_BP=17
MGNHAGKRELNAEKASTKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKA
TTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL

--------------------------------------------------------------
>52079_52079_2_MBP-PTPN2_MBP_chr18_74817167_ENST00000580402_PTPN2_chr18_12802150_ENST00000327283_length(transcript)=702nt_BP=51nt
ATGGGAAACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGAAACGATGGAAAGAACTTTCTAAGGAAGACTTATCTCCT
GCCTTTGATCATTCACCAAACAAAATAATGACTGAAAAATACAATGGGAACAGAATAGGTCTAGAAGAAGAAAAACTGACAGGTGACCGA
TGTACAGGACTTTCCTCTAAAATGCAAGATACAATGGAGGAGAACAGTGAGAGTGCTCTACGGAAACGTATTCGAGAGGACAGAAAGGCC
ACCACAGCTCAGAAGGTGCAGCAGATGAAACAGAGGCTAAATGAGAATGAACGAAAAAGAAAAAGGCCAAGATTGACAGACACCTAATAT
TCATGACTTGAGAATATTCTGCAGCTATAAATTTTGAACCATTGATGTGCAAAGCAAGACCTGAAGCCCACTCCGGAAACTAAAGTGAGG
CTCGCTAACCCTCTAGATTGCCTCACAGTTGTTTGTTTACAAAGTAAACTTTACATCCAGGGGATGAAGAGCACCCACCAGCAGAAGACT
TTGCAGAACCTTTAATTGGATGTGTTAAGTGTTTTTAATGAGTGTATGAAATGTAGAAAGATGTACAAGAAATAAATTAGGGGAGATTAC
TTTGTATTGTACTGCCATTCCTACTGTATTTTTATACTTTTTGGCAGCATTAAATATTTTTGTTAAATAGTC

>52079_52079_2_MBP-PTPN2_MBP_chr18_74817167_ENST00000580402_PTPN2_chr18_12802150_ENST00000327283_length(amino acids)=118AA_BP=17
MGNHAGKRELNAEKASTKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKA
TTAQKVQQMKQRLNENERKRKRPRLTDT

--------------------------------------------------------------
>52079_52079_3_MBP-PTPN2_MBP_chr18_74817167_ENST00000580402_PTPN2_chr18_12802150_ENST00000353319_length(transcript)=595nt_BP=51nt
ATGGGAAACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGAAACGATGGAAAGAACTTTCTAAGGAAGACTTATCTCCT
GCCTTTGATCATTCACCAAACAAAATAATGACTGAAAAATACAATGGGAACAGAATAGGTCTAGAAGAAGAAAAACTGACAGGTGACCGA
TGTACAGGACTTTCCTCTAAAATGCAAGATACAATGGAGGAGAACAGTGAGAGGCCAAGATTGACAGACACCTAATATTCATGACTTGAG
AATATTCTGCAGCTATAAATTTTGAACCATTGATGTGCAAAGCAAGACCTGAAGCCCACTCCGGAAACTAAAGTGAGGCTCGCTAACCCT
CTAGATTGCCTCACAGTTGTTTGTTTACAAAGTAAACTTTACATCCAGGGGATGAAGAGCACCCACCAGCAGAAGACTTTGCAGAACCTT
TAATTGGATGTGTTAAGTGTTTTTAATGAGTGTATGAAATGTAGAAAGATGTACAAGAAATAAATTAGGGGAGATTACTTTGTATTGTAC
TGCCATTCCTACTGTATTTTTATACTTTTTGGCAGCATTAAATATTTTTGTTAAA

>52079_52079_3_MBP-PTPN2_MBP_chr18_74817167_ENST00000580402_PTPN2_chr18_12802150_ENST00000353319_length(amino acids)=84AA_BP=17
MGNHAGKRELNAEKASTKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSERPRLTDT

--------------------------------------------------------------
>52079_52079_4_MBP-PTPN2_MBP_chr18_74817167_ENST00000580402_PTPN2_chr18_12802150_ENST00000591115_length(transcript)=699nt_BP=51nt
ATGGGAAACCACGCAGGCAAACGAGAATTAAATGCCGAGAAGGCCAGTACGAAACGATGGAAAGAACTTTCTAAGGAAGACTTATCTCCT
GCCTTTGATCATTCACCAAACAAAATAATGACTGAAAAATACAATGGGAACAGAATAGGTCTAGAAGAAGAAAAACTGACAGGTGACCGA
TGTACAGGACTTTCCTCTAAAATGCAAGATACAATGGAGGAGAACAGTGAGAGTGCTCTACGGAAACGTATTCGAGAGGACAGAAAGGCC
ACCACAGCTCAGAAGGTGCAGCAGATGAAACAGAGGCTAAATGAGAATGAACGAAAAAGAAAAAGGCCAAGATTGACAGACACCTAATAT
TCATGACTTGAGAATATTCTGCAGCTATAAATTTTGAACCATTGATGTGCAAAGCAAGACCTGAAGCCCACTCCGGAAACTAAAGTGAGG
CTCGCTAACCCTCTAGATTGCCTCACAGTTGTTTGTTTACAAAGTAAACTTTACATCCAGGGGATGAAGAGCACCCACCAGCAGAAGACT
TTGCAGAACCTTTAATTGGATGTGTTAAGTGTTTTTAATGAGTGTATGAAATGTAGAAAGATGTACAAGAAATAAATTAGGGGAGATTAC
TTTGTATTGTACTGCCATTCCTACTGTATTTTTATACTTTTTGGCAGCATTAAATATTTTTGTTAAATA

>52079_52079_4_MBP-PTPN2_MBP_chr18_74817167_ENST00000580402_PTPN2_chr18_12802150_ENST00000591115_length(amino acids)=118AA_BP=17
MGNHAGKRELNAEKASTKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKA
TTAQKVQQMKQRLNENERKRKRPRLTDT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MBP-PTPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MBP-PTPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MBP-PTPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMBPC0036341Schizophrenia4PSYGENET
HgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
HgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneMBPC0011303Demyelinating Diseases1CTD_human
HgeneMBPC0011304Demyelination1CTD_human
HgeneMBPC0027873Neuromyelitis Optica1CTD_human
HgeneMBPC2350037Clinically Isolated Syndrome, CNS Demyelinating1CTD_human
TgeneC0003873Rheumatoid Arthritis1CTD_human
TgeneC0009324Ulcerative Colitis1CTD_human;GENOMICS_ENGLAND
TgeneC0010346Crohn Disease1CTD_human
TgeneC0023492Leukemia, T-Cell1CTD_human
TgeneC0156147Crohn's disease of large bowel1CTD_human
TgeneC0267380Crohn's disease of the ileum1CTD_human
TgeneC0678202Regional enteritis1CTD_human
TgeneC0949272IIeocolitis1CTD_human
TgeneC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneC2931171Juvenile pauciarticular chronic arthritis1ORPHANET