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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MET-DYNC1I1 (FusionGDB2 ID:HG4233TG1780)

Fusion Gene Summary for MET-DYNC1I1

check button Fusion gene summary
Fusion gene informationFusion gene name: MET-DYNC1I1
Fusion gene ID: hg4233tg1780
HgeneTgene
Gene symbol

MET

DYNC1I1

Gene ID

4233

1780

Gene nameMET proto-oncogene, receptor tyrosine kinasedynein cytoplasmic 1 intermediate chain 1
SynonymsAUTS9|DFNB97|HGFR|RCCP2|c-MetDNCI1|DNCIC1
Cytomap('MET')('DYNC1I1')

7q31.2

7q21.3

Type of geneprotein-codingprotein-coding
Descriptionhepatocyte growth factor receptorHGF receptorHGF/SF receptorSF receptorproto-oncogene c-Metscatter factor receptortyrosine-protein kinase Metcytoplasmic dynein 1 intermediate chain 1DH IC-1cytoplasmic dynein intermediate chain 1dynein intermediate chain 1, cytosolicdynein, cytoplasmic, intermediate polypeptide 1
Modification date2020031520200313
UniProtAcc

P08581

.
Ensembl transtripts involved in fusion geneENST00000495962, ENST00000318493, 
ENST00000397752, ENST00000436117, 
ENST00000539704, 
Fusion gene scores* DoF score11 X 10 X 9=99012 X 12 X 6=864
# samples 1613
** MAII scorelog2(16/990*10)=-2.62935662007961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MET [Title/Abstract] AND DYNC1I1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMET(116371913)-DYNC1I1(95434033), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMET

GO:0001886

endothelial cell morphogenesis

14500721

HgeneMET

GO:0035024

negative regulation of Rho protein signal transduction

25198505

HgeneMET

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

HgeneMET

GO:0050918

positive chemotaxis

15218527

HgeneMET

GO:0051497

negative regulation of stress fiber assembly

25198505

HgeneMET

GO:0070495

negative regulation of thrombin-activated receptor signaling pathway

25198505

HgeneMET

GO:0071526

semaphorin-plexin signaling pathway

15218527

HgeneMET

GO:1905098

negative regulation of guanyl-nucleotide exchange factor activity

25198505



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AO-01AMETchr7

116371913

-DYNC1I1chr7

95434033

+
ChimerDB4BRCATCGA-AR-A1AO-01AMETchr7

116371913

+DYNC1I1chr7

95434033

+


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Fusion Gene ORF analysis for MET-DYNC1I1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000495962ENST00000324972METchr7

116371913

+DYNC1I1chr7

95434033

+
3UTR-5UTRENST00000495962ENST00000359388METchr7

116371913

+DYNC1I1chr7

95434033

+
3UTR-5UTRENST00000495962ENST00000413338METchr7

116371913

+DYNC1I1chr7

95434033

+
3UTR-5UTRENST00000495962ENST00000437599METchr7

116371913

+DYNC1I1chr7

95434033

+
3UTR-5UTRENST00000495962ENST00000447467METchr7

116371913

+DYNC1I1chr7

95434033

+
3UTR-5UTRENST00000495962ENST00000457059METchr7

116371913

+DYNC1I1chr7

95434033

+
3UTR-5UTRENST00000495962ENST00000537881METchr7

116371913

+DYNC1I1chr7

95434033

+
3UTR-intronENST00000495962ENST00000497626METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000318493ENST00000324972METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000318493ENST00000359388METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000318493ENST00000413338METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000318493ENST00000437599METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000318493ENST00000447467METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000318493ENST00000457059METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000318493ENST00000537881METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000397752ENST00000324972METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000397752ENST00000359388METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000397752ENST00000413338METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000397752ENST00000437599METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000397752ENST00000447467METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000397752ENST00000457059METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000397752ENST00000537881METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000436117ENST00000324972METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000436117ENST00000359388METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000436117ENST00000413338METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000436117ENST00000437599METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000436117ENST00000447467METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000436117ENST00000457059METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-5UTRENST00000436117ENST00000537881METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-intronENST00000318493ENST00000497626METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-intronENST00000397752ENST00000497626METchr7

116371913

+DYNC1I1chr7

95434033

+
5CDS-intronENST00000436117ENST00000497626METchr7

116371913

+DYNC1I1chr7

95434033

+
intron-5UTRENST00000539704ENST00000324972METchr7

116371913

+DYNC1I1chr7

95434033

+
intron-5UTRENST00000539704ENST00000359388METchr7

116371913

+DYNC1I1chr7

95434033

+
intron-5UTRENST00000539704ENST00000413338METchr7

116371913

+DYNC1I1chr7

95434033

+
intron-5UTRENST00000539704ENST00000437599METchr7

116371913

+DYNC1I1chr7

95434033

+
intron-5UTRENST00000539704ENST00000447467METchr7

116371913

+DYNC1I1chr7

95434033

+
intron-5UTRENST00000539704ENST00000457059METchr7

116371913

+DYNC1I1chr7

95434033

+
intron-5UTRENST00000539704ENST00000537881METchr7

116371913

+DYNC1I1chr7

95434033

+
intron-intronENST00000539704ENST00000497626METchr7

116371913

+DYNC1I1chr7

95434033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MET-DYNC1I1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MET-DYNC1I1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:116371913/:95434033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MET

P08581

.
FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). {ECO:0000250|UniProtKB:P16056}.; FUNCTION: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. {ECO:0000269|PubMed:11081636, ECO:0000305|PubMed:17662939, ECO:0000305|PubMed:19900460}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MET-DYNC1I1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MET-DYNC1I1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MET-DYNC1I1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMETP08581DB08865CrizotinibInhibitorSmall moleculeApproved
HgeneMETP08581DB08875CabozantinibAntagonistSmall moleculeApproved|Investigational
HgeneMETP08581DB11791CapmatinibInhibitorSmall moleculeApproved|Investigational
HgeneMETP08581DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneMETP08581DB12267BrigatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for MET-DYNC1I1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMETC1306837Papillary Renal Cell Carcinoma9CGI;CLINGEN;CTD_human;ORPHANET
HgeneMETC1336078Papillary renal cell carcinoma, sporadic7CLINGEN
HgeneMETC1336839Type 1 Papillary Renal Cell Carcinoma5UNIPROT
HgeneMETC0007131Non-Small Cell Lung Carcinoma4CGI;CTD_human
HgeneMETC1836723Tibia, Bowing of, with Pseudarthrosis and Pectus Excavatum4ORPHANET
HgeneMETC4085248OSTEOFIBROUS DYSPLASIA, SUSCEPTIBILITY TO4ORPHANET
HgeneMETC0001418Adenocarcinoma2CTD_human
HgeneMETC0004352Autistic Disorder2CTD_human
HgeneMETC0024623Malignant neoplasm of stomach2CGI;CTD_human;UNIPROT
HgeneMETC0027627Neoplasm Metastasis2CTD_human
HgeneMETC0038356Stomach Neoplasms2CGI;CTD_human
HgeneMETC0205641Adenocarcinoma, Basal Cell2CTD_human
HgeneMETC0205642Adenocarcinoma, Oxyphilic2CTD_human
HgeneMETC0205643Carcinoma, Cribriform2CTD_human
HgeneMETC0205644Carcinoma, Granular Cell2CTD_human
HgeneMETC0205645Adenocarcinoma, Tubular2CTD_human
HgeneMETC1708349Hereditary Diffuse Gastric Cancer2CTD_human
HgeneMETC0004114Astrocytoma1CTD_human
HgeneMETC0007097Carcinoma1CTD_human
HgeneMETC0007134Renal Cell Carcinoma1CTD_human
HgeneMETC0007137Squamous cell carcinoma1CTD_human
HgeneMETC0009241Cognition Disorders1CTD_human
HgeneMETC0014859Esophageal Neoplasms1CTD_human
HgeneMETC0017636Glioblastoma1CTD_human
HgeneMETC0019189Hepatitis, Chronic1CTD_human
HgeneMETC0019207Hepatoma, Morris1CTD_human
HgeneMETC0019208Hepatoma, Novikoff1CTD_human
HgeneMETC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneMETC0023904Liver Neoplasms, Experimental1CTD_human
HgeneMETC0024121Lung Neoplasms1CTD_human
HgeneMETC0024232Lymphatic Metastasis1CTD_human
HgeneMETC0025202melanoma1CTD_human
HgeneMETC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneMETC0027626Neoplasm Invasiveness1CTD_human
HgeneMETC0027819Neuroblastoma1CTD_human
HgeneMETC0029463Osteosarcoma1CTD_human
HgeneMETC0033578Prostatic Neoplasms1CTD_human
HgeneMETC0036341Schizophrenia1CTD_human
HgeneMETC0037199Sinusitis1CTD_human
HgeneMETC0086404Experimental Hepatoma1CTD_human
HgeneMETC0149519Chronic Persistent Hepatitis1CTD_human
HgeneMETC0205696Anaplastic carcinoma1CTD_human
HgeneMETC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneMETC0205698Undifferentiated carcinoma1CTD_human
HgeneMETC0205699Carcinomatosis1CTD_human
HgeneMETC0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneMETC0242379Malignant neoplasm of lung1CTD_human
HgeneMETC0279606Childhood Hepatocellular Carcinoma1ORPHANET
HgeneMETC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CGI;CTD_human
HgeneMETC0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneMETC0280785Diffuse Astrocytoma1CTD_human
HgeneMETC0334579Anaplastic astrocytoma1CTD_human
HgeneMETC0334580Protoplasmic astrocytoma1CTD_human
HgeneMETC0334581Gemistocytic astrocytoma1CTD_human
HgeneMETC0334582Fibrillary Astrocytoma1CTD_human
HgeneMETC0334583Pilocytic Astrocytoma1CTD_human
HgeneMETC0334588Giant Cell Glioblastoma1CTD_human
HgeneMETC0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneMETC0345967Malignant mesothelioma1CTD_human
HgeneMETC0376358Malignant neoplasm of prostate1CTD_human
HgeneMETC0520463Chronic active hepatitis1CTD_human
HgeneMETC0524611Cryptogenic Chronic Hepatitis1CTD_human
HgeneMETC0546837Malignant neoplasm of esophagus1CTD_human
HgeneMETC0547065Mixed oligoastrocytoma1CTD_human
HgeneMETC0750935Cerebral Astrocytoma1CTD_human
HgeneMETC0750936Intracranial Astrocytoma1CTD_human
HgeneMETC0919267ovarian neoplasm1CTD_human
HgeneMETC1140680Malignant neoplasm of ovary1CTD_human
HgeneMETC1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneMETC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneMETC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneMETC1621958Glioblastoma Multiforme1CTD_human
HgeneMETC1704230Grade I Astrocytoma1CTD_human
HgeneMETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome1CLINGEN
HgeneMETC1876165Copper-Overload Cirrhosis1CTD_human
HgeneMETC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneMETC2239176Liver carcinoma1CGI;CTD_human;UNIPROT
HgeneMETC3711374Nonsyndromic Deafness1CLINGEN
HgeneMETC4084709DEAFNESS, AUTOSOMAL RECESSIVE 971CTD_human;UNIPROT
TgeneC4721453Peripheral Nervous System Diseases1CTD_human