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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AFF1-U2SURP (FusionGDB2 ID:HG4299TG23350)

Fusion Gene Summary for AFF1-U2SURP

check button Fusion gene summary
Fusion gene informationFusion gene name: AFF1-U2SURP
Fusion gene ID: hg4299tg23350
HgeneTgene
Gene symbol

AFF1

U2SURP

Gene ID

4299

23350

Gene nameAF4/FMR2 family member 1U2 snRNP associated SURP domain containing
SynonymsAF4|MLLT2|PBM1SR140|fSAPa
Cytomap('AFF1')('U2SURP')

4q21.3-q22.1

3q23

Type of geneprotein-codingprotein-coding
DescriptionAF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4U2 snRNP-associated SURP motif-containing protein140 kDa Ser/Arg-rich domain proteinSer/Arg-rich domain protein, 140 kDaU2-associated SR140 proteinU2-associated protein SR140functional spliceosome-associated protein a
Modification date2020031320200313
UniProtAcc

P51825

.
Ensembl transtripts involved in fusion geneENST00000511996, ENST00000395146, 
ENST00000307808, ENST00000544085, 
Fusion gene scores* DoF score27 X 51 X 13=179019 X 10 X 3=270
# samples 6811
** MAII scorelog2(68/17901*10)=-4.71836162613835
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/270*10)=-1.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AFF1 [Title/Abstract] AND U2SURP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAFF1(87869723)-U2SURP(142751625), # samples:1
Anticipated loss of major functional domain due to fusion event.AFF1-U2SURP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-U2SURP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-U2SURP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-U2SURP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AFF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across U2SURP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer2397NAFF1chr4

87869723

+U2SURPchr3

142751625

+


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Fusion Gene ORF analysis for AFF1-U2SURP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000511996ENST00000397933AFF1chr4

87869723

+U2SURPchr3

142751625

+
3UTR-3CDSENST00000511996ENST00000473835AFF1chr4

87869723

+U2SURPchr3

142751625

+
3UTR-3CDSENST00000511996ENST00000493598AFF1chr4

87869723

+U2SURPchr3

142751625

+
In-frameENST00000395146ENST00000397933AFF1chr4

87869723

+U2SURPchr3

142751625

+
In-frameENST00000395146ENST00000473835AFF1chr4

87869723

+U2SURPchr3

142751625

+
In-frameENST00000395146ENST00000493598AFF1chr4

87869723

+U2SURPchr3

142751625

+
intron-3CDSENST00000307808ENST00000397933AFF1chr4

87869723

+U2SURPchr3

142751625

+
intron-3CDSENST00000307808ENST00000473835AFF1chr4

87869723

+U2SURPchr3

142751625

+
intron-3CDSENST00000307808ENST00000493598AFF1chr4

87869723

+U2SURPchr3

142751625

+
intron-3CDSENST00000544085ENST00000397933AFF1chr4

87869723

+U2SURPchr3

142751625

+
intron-3CDSENST00000544085ENST00000473835AFF1chr4

87869723

+U2SURPchr3

142751625

+
intron-3CDSENST00000544085ENST00000493598AFF1chr4

87869723

+U2SURPchr3

142751625

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395146AFF1chr487869723+ENST00000397933U2SURPchr3142751625+60683132661792508
ENST00000395146AFF1chr487869723+ENST00000473835U2SURPchr3142751625+58893132661792508
ENST00000395146AFF1chr487869723+ENST00000493598U2SURPchr3142751625+21893132661792508

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395146ENST00000397933AFF1chr487869723+U2SURPchr3142751625+9.45E-050.99990547
ENST00000395146ENST00000473835AFF1chr487869723+U2SURPchr3142751625+9.85E-050.99990153
ENST00000395146ENST00000493598AFF1chr487869723+U2SURPchr3142751625+0.0005693280.9994306

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Fusion Genomic Features for AFF1-U2SURP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AFF1chr487869723+U2SURPchr3142751625+1.46E-070.9999999
AFF1chr487869723+U2SURPchr3142751625+1.46E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AFF1-U2SURP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:87869723/chr3:142751625)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFF1

P51825

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneU2SURPchr4:87869723chr3:142751625ENST000003979331427192_232127621.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr4:87869723chr3:142751625ENST000003979331427837_915127621.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr4:87869723chr3:142751625ENST000004738351528837_9155361030.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr4:87869723chr3:142751625ENST000003979331427357_402127621.0Compositional biasNote=Pro-rich
TgeneU2SURPchr4:87869723chr3:142751625ENST000003979331427689_746127621.0Compositional biasNote=Asp-rich
TgeneU2SURPchr4:87869723chr3:142751625ENST000003979331427762_917127621.0Compositional biasNote=Glu-rich
TgeneU2SURPchr4:87869723chr3:142751625ENST000003979331427922_1001127621.0Compositional biasNote=Arg/Ser-rich
TgeneU2SURPchr4:87869723chr3:142751625ENST000004738351528689_7465361030.0Compositional biasNote=Asp-rich
TgeneU2SURPchr4:87869723chr3:142751625ENST000004738351528762_9175361030.0Compositional biasNote=Glu-rich
TgeneU2SURPchr4:87869723chr3:142751625ENST000004738351528922_10015361030.0Compositional biasNote=Arg/Ser-rich
TgeneU2SURPchr4:87869723chr3:142751625ENST000003979331427274_355127621.0DomainRRM
TgeneU2SURPchr4:87869723chr3:142751625ENST000003979331427534_679127621.0DomainCID
TgeneU2SURPchr4:87869723chr3:142751625ENST000004738351528534_6795361030.0DomainCID
TgeneU2SURPchr4:87869723chr3:142751625ENST000003979331427430_473127621.0RepeatNote=SURP motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAFF1chr4:87869723chr3:142751625ENST00000307808+120483_49201211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:87869723chr3:142751625ENST00000307808+120835_84301211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:87869723chr3:142751625ENST00000307808+120866_86901211.0Compositional biasNote=Poly-Pro
HgeneAFF1chr4:87869723chr3:142751625ENST00000307808+120871_87401211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:87869723chr3:142751625ENST00000395146+221483_492121219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:87869723chr3:142751625ENST00000395146+221835_843121219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:87869723chr3:142751625ENST00000395146+221866_869121219.0Compositional biasNote=Poly-Pro
HgeneAFF1chr4:87869723chr3:142751625ENST00000395146+221871_874121219.0Compositional biasNote=Poly-Ser
TgeneU2SURPchr4:87869723chr3:142751625ENST00000397933142792_121127621.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr4:87869723chr3:142751625ENST000004738351528192_2325361030.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr4:87869723chr3:142751625ENST00000473835152892_1215361030.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr4:87869723chr3:142751625ENST000004738351528357_4025361030.0Compositional biasNote=Pro-rich
TgeneU2SURPchr4:87869723chr3:142751625ENST000004738351528274_3555361030.0DomainRRM
TgeneU2SURPchr4:87869723chr3:142751625ENST000004738351528430_4735361030.0RepeatNote=SURP motif


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Fusion Gene Sequence for AFF1-U2SURP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2668_2668_1_AFF1-U2SURP_AFF1_chr4_87869723_ENST00000395146_U2SURP_chr3_142751625_ENST00000397933_length(transcript)=6068nt_BP=313nt
GAGCTTGCCAGCCAGCTAGCGAGCGACGGGCGCGCGCGGCCCCTGCGCACTCGGCCGCCGCCTGCGCGCGTTGCGGCCGCAGCTGCACCT
TTGCCTCCGCGGTTCCGCAGCCGAGCCCCGGGAGGAGGCGCTCCCCTGCGTCGTCCGCACTTGCGCCCTTTCCCACCGCAACAGGTCAGG
GGAGGGCGGAGGTGACGAGGGCGCCCGACCCGGGACTAGAGGACGGAAGGGTCTGGAAGATGAACAGACTAGCCACTTTGCATTGACTGG
AAACAATGGCATTTACAGAAAGAGTCAACAGCAGTGGCAACAGACAGAGGGATAAATTGGAAGAAATCTTGCGGGGATTAACTCCAAGGA
AAAATGATATTGGAGATGCAATGGTTTTCTGTCTTAATAATGCTGAAGCTGCTGAAGAAATAGTGGATTGCATTACTGAGTCGTTGTCCA
TCTTAAAGACACCCCTTCCTAAAAAGATTGCCAGATTATATTTGGTTTCTGATGTTTTGTACAACTCTTCAGCCAAAGTTGCTAATGCTT
CATATTATAGAAAATTTTTTGAAACAAAGTTATGTCAGATATTTTCAGACCTCAATGCCACCTATCGTACAATTCAAGGCCATTTACAAT
CTGAAAACTTTAAGCAACGGGTAATGACTTGCTTCAGAGCATGGGAAGATTGGGCAATTTATCCAGAACCATTTTTGATCAAACTACAAA
ATATTTTCTTAGGACTTGTAAATATTATTGAAGAAAAGGAAACAGAGGATGTTCCAGATGACCTTGATGGTGCCCCCATCGAGGAAGAGC
TTGATGGTGCACCTCTGGAAGATGTAGATGGAATTCCTATTGATGCTACTCCCATCGATGATCTTGATGGAGTCCCTATAAAAAGTCTTG
ATGATGATCTTGATGGAGTGCCTTTGGATGCAACTGAAGACTCAAAAAAGAATGAGCCTATATTTAAAGTTGCCCCATCAAAATGGGAAG
CTGTGGATGAATCTGAATTGGAAGCACAGGCTGTTACAACTTCTAAATGGGAATTATTTGACCAGCATGAAGAATCAGAAGAAGAAGAAA
ATCAAAATCAAGAAGAAGAAAGTGAAGATGAAGAAGATACTCAAAGTTCCAAATCTGAAGAACATCATTTGTACTCTAATCCAATCAAAG
AAGAAATGACTGAGTCTAAGTTCTCTAAGTACTCTGAAATGAGTGAGGAAAAACGAGCCAAACTTCGTGAAATTGAGCTCAAAGTTATGA
AGTTTCAGGATGAATTGGAATCTGGGAAAAGACCTAAAAAACCAGGCCAGAGTTTTCAGGAGCAAGTAGAACACTACAGAGATAAACTTC
TTCAACGAGAGAAAGAGAAAGAGTTAGAAAGAGAACGAGAAAGAGACAAGAAAGATAAAGAAAAATTGGAATCTCGCTCCAAAGACAAGA
AGGAAAAAGATGAGTGTACTCCGACAAGGAAGGAAAGGAAGAGGCGACACAGTACATCCCCCAGCCCATCTCGCAGTAGCAGTGGTAGAC
GAGTGAAATCCCCATCACCAAAATCGGAGCGATCAGAGCGTTCAGAAAGATCTCATAAAGAGAGCTCACGGTCCAGGTCATCTCACAAAG
ATTCTCCTAGAGATGTTAGCAAAAAAGCCAAAAGATCACCATCTGGTTCAAGGACACCTAAAAGGTCTAGGCGATCACGGTCTAGATCTC
CTAAAAAATCAGGAAAGAAGTCCAGATCCCAGTCCAGATCTCCACACAGGTCTCATAAAAAGTCAAAGAAAAACAAACACTGACGTAAAT
TTTTAAGATGCTGTCACTTATTGGAAATGCGATTTGTTTTGTGCCTGAACGGTCTGTTTTTTAAAAAAACAAAAAATCAAATGAAAGAGC
ATTCCTGGGGTTTTTTGTTTGTTTGTGTATGCATGTGTAAACTCATGAGCAACTGCATCTGTAGATCTGTCATTGTTTTATATTGTGTAA
ATTACTTTCATTGTGGCTATTTCTCAAGATGAAATTTTTATTGTTCTAATGGATTTCATCAGAAATGTGTATAATGGATCTGCTGACAGT
AGTAGTATTTTGTTTTAGGATGTTGTGACTTAGCAAAAATAATACAGATGTCTTCCCCCCTTTTGTAGCTTTGACAATTTGAATTAGATT
TCAAATAAAATCTGAACAGAAAACTATAATGTTGTTTTTTTGCCCCACCGGTGATATTAAGTCCCTTAAAGTCCTACTGAGTTTCACACT
ACTGTTGTGCTTCTTATACCTGATGCACTTTATAAGCCCCAGTGTTCAAGTAGCTTAAGTTTTATATTTACTAAGATGACTATCCAAATT
AAGGGACCTGAGACTCCTATTTGGTGGTTTGCTAACCATTTGCTTTTGATAAGTTTCTCTTGGGTAATACTAATACCCAGATATCAAAGA
CTAGGTAGATATGGCATGGCGTTTTGTTAGTGGAATGCCTGGCTAAAACATTTTTTTCACAGAAGCAATATGATTTCCATACATCCAACC
CATGTTCTGAGCAACTACTTACTTTTAGGGGGAAATTAAATATCTTTTCATTTCCTCTTCTATTATGAAAGAAGTTTATTTGTAAAACAA
ATTTTCTAACAAGGTTTGGCCATAGAATTCTCTTGTATGATCGTTGACCTTTTATAATCTTCTGTAGGCTATCTTTCAAACACTGGCATC
AGAATATTTTTTATAAGTTTGTGTTTAAACAGCTTAGTTGGTCCCCCCCCACTCCCAAGAGACTTGGGTTTAGTTATAGCTTTAAGTAAA
ATTTAAAAATAAAATGTTTTTCAGGAAACTTCGTATCTAATGGTTTGTAAATTCAAGGTGCAAAAAGTTGATTTAAACCATTTGCAGAGT
TGAACTCTATTATGAAAATAAATTTGCTACGGTATGAGGAAGAAATAAAACTTGTGTAATGTTGGTCATAATACTGCTATAAATATAATA
AAGGGTTATGTAGAATTGAACTGACACTATTATTTGTGAATCTTGATTTCAGTTTTTTATGTAGGCACTTCATACACTGGTTTGATGGGT
TTTTTTTTTCCTCCCTAAAAGAGAAAGTAGAAAACTATTCTAACAATGGATTATTTTGATTTAGCTTGCTTTTTAAAAAAATCTTTTCAA
CTTGTTTTACTTAATCTTGCCTAGTCACAAAATAAGATGTGCACCCATGGTTTGGAGAGTTCCTATATTAGCTGAGCAGTGAGATACACT
ATTTCCAAACGGTGCACACCTACAGTAGCTTTGGAAATGAGCCAATCACTGTTTTACTTAATGGTTCTTATCAGCATGCAAATATTGCTT
GAAAGTTATTTCCTTATTCACTGTTTTGTTAGTCCATTTTGTTAGGAAACATTAATTCCTAAAAATTTGTTCAGAATAATTAAAAGTGAA
CATTTGGTGCTGATACTCAAAAACCTACAAATGTAGCCATTTAAAAAGTAACATGTTTTTCTCCCCTGCTCATTGCCTGGGAGAATGGAA
TTTTATATAACTACCTTTCTTTGCAAAAATAACGGTCGTGTCGAGTTGGTGGTGATTTTGGCATTCCATCTTGCACTGGTTTCTAGTATA
GGCTTAGAAATAATTGGTCAGGTAATAATCTTTCCAGTCAAGTTGCAAGGGATGCTTATTTCTCTTCAAAAAAAGACATCCTGCGGGATT
GAGTAGAAAATTTTAGGTCAGTTTTGGGTGCTTATTTGTAATATTTTTCCTACTACATTGGAGTTTAGCAGTTCTTTTTTTCTGGATCCA
GATACAAGTGTCATGGTTTATCTTACAGTGGGTGAAACTGACTTTCTTTTGGTTGGGTGGGTGAGGATTTCTTAGGCCTGATAGAATATA
TATTCTGTGAAGTTTGTTAATGTACATATTAGATTGTATTGGATTTTTTTTTCTTGAATTGCAAATGGTATTATTAGATAGGTTATTTCC
AGTTTTACTTCATGACAAATTACCTAGAGTAAACCTACTTAATACTCCCATGGATTCTATGAAAGTTTAATGGGATCAGAAATTGGTGAC
TTATAAGGGGGAAGATATTCTACCATATTTTTATAATAGCTTATTATTCATGTTTCTTGTCTGAAGGACACTCAAGTTACAGAGCAAAAT
TTCTATAGGTTGACTAGAATGTTCATAAGCATGGTCTTCCAGTTGCAGGAAAGATCATGTTCTATCTGTGGACACTTACTGTCCTCTACC
ACAGCTACGTGCCAGAGTTGTTTTCCACAGTTCTTATAAAGGGCATGACTTAGGCTCTTTACCCTCCAACTTAATGTTTATACACAGGGA
TTGTTTACTAGGTTAATGACATTTAACTCCCCTCTCTTCTGTAGGTGAGAGAAAATAAGTAAGTCTTGATCTGTTTCTTACCAAAGAGAG
ACAGACCTATGATGGAAAATGATCACGTCTCTGAATTTTTTCTTTAACGTTATAGTTCCTTATTACAGATAGTAAGCATATGGGAATTTC
TGAGCTATAACATGTTGAGAAGTTAGAAATTAAAACTAACACAACAAAAGGCGCTGAATCAAAAGATCTTTGCTTTTATTTGGCTCAGAA
TGTTTTTGGCTTTTCTGCTAAAGATGGCAGAAATTACTCTACACAGACCTGATTTTTCTTTATTGCAGACCATTCTTGTGGGCTTACCCT
GAGACTTTTATCCCAATTAGTGAATCTTGGAGGGAATACTTGCTTATTTATGACTTAGGTATTTCCCCCCAAACTTTAATATTCTTGAGC
ACTTGAAAATACTTTTGAGAAATTTTAACTGTGATTAAATTTAGGTTTATTAGAAATATTCTGTACACATTTGCCTCCATGGTGGCGTAA
GTTCTGAAAAATTATATGACCGTGACAATAGTTTATCATCATCATTATTGTTATTCAAAATAAGGGTAAATAAATCTCTGTATTGCCAAA
GTGACTTAAACTGTTCTGATGACCACACAGTGTGATTTCTTTAGCAGAGAAAGTTGGTTTTAAAAATAAATAGTACCACTTTTCTAAGAC
TGTACAGTTTACAAATAAGGTTTTTTTCTTTGTTGTTTTCCTCTTCTATTAAGTTTTAGTGAAAAGCCTAATTACAGAAAATTGTGCAGA
TACTAGTGAAGATACTAGTATAAGTTTAAAGGAACACGTGACTGTAAAATCTCACATTTACAAAGTGCTTGATCTCTTCATATTTCACAC
GCATGTTTTAGAATAGATTTTAGGGAGTGTTTAATTCATTATCCTTTTGACTTAAAATTTTTGTTACCAACTTCCTAGGACTTAGATAAT
ATATAAATAAGTACAAATCCCAGGGGAAGTGTTGTGATGCTAGACTAAAAGGTGGGAATGTGCTGCTGTTCCGTGAGCCTTGTTCCATTG
TTGAAAATTTGATGCCTCAGTGTTTATTCAGTACCACCTCATGGAGCTTCAATGTAAATGGATTATATGTATAATTGGTAATTTGTATAG
TTTTGTAGATTGTAGATTAAATGCACTCATCATGTCACATGTAATTGTGCTTGGAGTATTTGTGTTTTATTCTTTTACTTCAACGGGTTC
TTGTCTGTTACATCTCTGGTGATTTGAAATATCAGGAAAGACAGTTTGTCAGAAATGAGAATAATATAGTTGAAATCAGTTGGGCTAAAA
TATTCTACAGCAAGACAATTTCTTTTGGGTGAACTGATTCTATAATTTACTTACTTTTAATGTAAGGATTAGATTTATTGTTGAGCTGCT
TTCCAGATCAGACTGTCACTTTATAGTTTTTCTACATAAAGATTATATAGTTGCAAACAAAGGTTGTGAAATTTCCCTTTTGTTGTTTTT
GACTTTTAATTAATAAAAGTACATTGTTTTCATAGCAAACTTAGACTGTCCATGTAATTTTCTCCATATTGTTTTTCCGATGCAAGCCCA
GTTAATAATTAGTTTTTTAGCAGCTTTCTCTCAAGTGAAATAAGTGATGTGACATGTTTATCAGTTATGGCTAAAATGTTACACTTTACA
TGTTTAAACTATAATCATATGTTTTCATGCTAGATGGT

>2668_2668_1_AFF1-U2SURP_AFF1_chr4_87869723_ENST00000395146_U2SURP_chr3_142751625_ENST00000397933_length(amino acids)=508AA_BP=15
METMAFTERVNSSGNRQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVAN
ASYYRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEE
ELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEE
ENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDK
LLQREKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSH
KDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNKH

--------------------------------------------------------------
>2668_2668_2_AFF1-U2SURP_AFF1_chr4_87869723_ENST00000395146_U2SURP_chr3_142751625_ENST00000473835_length(transcript)=5889nt_BP=313nt
GAGCTTGCCAGCCAGCTAGCGAGCGACGGGCGCGCGCGGCCCCTGCGCACTCGGCCGCCGCCTGCGCGCGTTGCGGCCGCAGCTGCACCT
TTGCCTCCGCGGTTCCGCAGCCGAGCCCCGGGAGGAGGCGCTCCCCTGCGTCGTCCGCACTTGCGCCCTTTCCCACCGCAACAGGTCAGG
GGAGGGCGGAGGTGACGAGGGCGCCCGACCCGGGACTAGAGGACGGAAGGGTCTGGAAGATGAACAGACTAGCCACTTTGCATTGACTGG
AAACAATGGCATTTACAGAAAGAGTCAACAGCAGTGGCAACAGACAGAGGGATAAATTGGAAGAAATCTTGCGGGGATTAACTCCAAGGA
AAAATGATATTGGAGATGCAATGGTTTTCTGTCTTAATAATGCTGAAGCTGCTGAAGAAATAGTGGATTGCATTACTGAGTCGTTGTCCA
TCTTAAAGACACCCCTTCCTAAAAAGATTGCCAGATTATATTTGGTTTCTGATGTTTTGTACAACTCTTCAGCCAAAGTTGCTAATGCTT
CATATTATAGAAAATTTTTTGAAACAAAGTTATGTCAGATATTTTCAGACCTCAATGCCACCTATCGTACAATTCAAGGCCATTTACAAT
CTGAAAACTTTAAGCAACGGGTAATGACTTGCTTCAGAGCATGGGAAGATTGGGCAATTTATCCAGAACCATTTTTGATCAAACTACAAA
ATATTTTCTTAGGACTTGTAAATATTATTGAAGAAAAGGAAACAGAGGATGTTCCAGATGACCTTGATGGTGCCCCCATCGAGGAAGAGC
TTGATGGTGCACCTCTGGAAGATGTAGATGGAATTCCTATTGATGCTACTCCCATCGATGATCTTGATGGAGTCCCTATAAAAAGTCTTG
ATGATGATCTTGATGGAGTGCCTTTGGATGCAACTGAAGACTCAAAAAAGAATGAGCCTATATTTAAAGTTGCCCCATCAAAATGGGAAG
CTGTGGATGAATCTGAATTGGAAGCACAGGCTGTTACAACTTCTAAATGGGAATTATTTGACCAGCATGAAGAATCAGAAGAAGAAGAAA
ATCAAAATCAAGAAGAAGAAAGTGAAGATGAAGAAGATACTCAAAGTTCCAAATCTGAAGAACATCATTTGTACTCTAATCCAATCAAAG
AAGAAATGACTGAGTCTAAGTTCTCTAAGTACTCTGAAATGAGTGAGGAAAAACGAGCCAAACTTCGTGAAATTGAGCTCAAAGTTATGA
AGTTTCAGGATGAATTGGAATCTGGGAAAAGACCTAAAAAACCAGGCCAGAGTTTTCAGGAGCAAGTAGAACACTACAGAGATAAACTTC
TTCAACGAGAGAAAGAGAAAGAGTTAGAAAGAGAACGAGAAAGAGACAAGAAAGATAAAGAAAAATTGGAATCTCGCTCCAAAGACAAGA
AGGAAAAAGATGAGTGTACTCCGACAAGGAAGGAAAGGAAGAGGCGACACAGTACATCCCCCAGCCCATCTCGCAGTAGCAGTGGTAGAC
GAGTGAAATCCCCATCACCAAAATCGGAGCGATCAGAGCGTTCAGAAAGATCTCATAAAGAGAGCTCACGGTCCAGGTCATCTCACAAAG
ATTCTCCTAGAGATGTTAGCAAAAAAGCCAAAAGATCACCATCTGGTTCAAGGACACCTAAAAGGTCTAGGCGATCACGGTCTAGATCTC
CTAAAAAATCAGGAAAGAAGTCCAGATCCCAGTCCAGATCTCCACACAGGTCTCATAAAAAGTCAAAGAAAAACAAACACTGACGTAAAT
TTTTAAGATGCTGTCACTTATTGGAAATGCGATTTGTTTTGTGCCTGAACGGTCTGTTTTTTAAAAAAACAAAAAATCAAATGAAAGAGC
ATTCCTGGGGTTTTTTGTTTGTTTGTGTATGCATGTGTAAACTCATGAGCAACTGCATCTGTAGATCTGTCATTGTTTTATATTGTGTAA
ATTACTTTCATTGTGGCTATTTCTCAAGATGAAATTTTTATTGTTCTAATGGATTTCATCAGAAATGTGTATAATGGATCTGCTGACAGT
AGTAGTATTTTGTTTTAGGATGTTGTGACTTAGCAAAAATAATACAGATGTCTTCCCCCCTTTTGTAGCTTTGACAATTTGAATTAGATT
TCAAATAAAATCTGAACAGAAAACTATAATGTTGTTTTTTTGCCCCACCGGTGATATTAAGTCCCTTAAAGTCCTACTGAGTTTCACACT
ACTGTTGTGCTTCTTATACCTGATGCACTTTATAAGCCCCAGTGTTCAAGTAGCTTAAGTTTTATATTTACTAAGATGACTATCCAAATT
AAGGGACCTGAGACTCCTATTTGGTGGTTTGCTAACCATTTGCTTTTGATAAGTTTCTCTTGGGTAATACTAATACCCAGATATCAAAGA
CTAGGTAGATATGGCATGGCGTTTTGTTAGTGGAATGCCTGGCTAAAACATTTTTTTCACAGAAGCAATATGATTTCCATACATCCAACC
CATGTTCTGAGCAACTACTTACTTTTAGGGGGAAATTAAATATCTTTTCATTTCCTCTTCTATTATGAAAGAAGTTTATTTGTAAAACAA
ATTTTCTAACAAGGTTTGGCCATAGAATTCTCTTGTATGATCGTTGACCTTTTATAATCTTCTGTAGGCTATCTTTCAAACACTGGCATC
AGAATATTTTTTATAAGTTTGTGTTTAAACAGCTTAGTTGGTCCCCCCCCACTCCCAAGAGACTTGGGTTTAGTTATAGCTTTAAGTAAA
ATTTAAAAATAAAATGTTTTTCAGGAAACTTCGTATCTAATGGTTTGTAAATTCAAGGTGCAAAAAGTTGATTTAAACCATTTGCAGAGT
TGAACTCTATTATGAAAATAAATTTGCTACGGTATGAGGAAGAAATAAAACTTGTGTAATGTTGGTCATAATACTGCTATAAATATAATA
AAGGGTTATGTAGAATTGAACTGACACTATTATTTGTGAATCTTGATTTCAGTTTTTTATGTAGGCACTTCATACACTGGTTTGATGGGT
TTTTTTTTTCCTCCCTAAAAGAGAAAGTAGAAAACTATTCTAACAATGGATTATTTTGATTTAGCTTGCTTTTTAAAAAAATCTTTTCAA
CTTGTTTTACTTAATCTTGCCTAGTCACAAAATAAGATGTGCACCCATGGTTTGGAGAGTTCCTATATTAGCTGAGCAGTGAGATACACT
ATTTCCAAACGGTGCACACCTACAGTAGCTTTGGAAATGAGCCAATCACTGTTTTACTTAATGGTTCTTATCAGCATGCAAATATTGCTT
GAAAGTTATTTCCTTATTCACTGTTTTGTTAGTCCATTTTGTTAGGAAACATTAATTCCTAAAAATTTGTTCAGAATAATTAAAAGTGAA
CATTTGGTGCTGATACTCAAAAACCTACAAATGTAGCCATTTAAAAAGTAACATGTTTTTCTCCCCTGCTCATTGCCTGGGAGAATGGAA
TTTTATATAACTACCTTTCTTTGCAAAAATAACGGTCGTGTCGAGTTGGTGGTGATTTTGGCATTCCATCTTGCACTGGTTTCTAGTATA
GGCTTAGAAATAATTGGTCAGGTAATAATCTTTCCAGTCAAGTTGCAAGGGATGCTTATTTCTCTTCAAAAAAAGACATCCTGCGGGATT
GAGTAGAAAATTTTAGGTCAGTTTTGGGTGCTTATTTGTAATATTTTTCCTACTACATTGGAGTTTAGCAGTTCTTTTTTTCTGGATCCA
GATACAAGTGTCATGGTTTATCTTACAGTGGGTGAAACTGACTTTCTTTTGGTTGGGTGGGTGAGGATTTCTTAGGCCTGATAGAATATA
TATTCTGTGAAGTTTGTTAATGTACATATTAGATTGTATTGGATTTTTTTTTCTTGAATTGCAAATGGTATTATTAGATAGGTTATTTCC
AGTTTTACTTCATGACAAATTACCTAGAGTAAACCTACTTAATACTCCCATGGATTCTATGAAAGTTTAATGGGATCAGAAATTGGTGAC
TTATAAGGGGGAAGATATTCTACCATATTTTTATAATAGCTTATTATTCATGTTTCTTGTCTGAAGGACACTCAAGTTACAGAGCAAAAT
TTCTATAGGTTGACTAGAATGTTCATAAGCATGGTCTTCCAGTTGCAGGAAAGATCATGTTCTATCTGTGGACACTTACTGTCCTCTACC
ACAGCTACGTGCCAGAGTTGTTTTCCACAGTTCTTATAAAGGGCATGACTTAGGCTCTTTACCCTCCAACTTAATGTTTATACACAGGGA
TTGTTTACTAGGTTAATGACATTTAACTCCCCTCTCTTCTGTAGGTGAGAGAAAATAAGTAAGTCTTGATCTGTTTCTTACCAAAGAGAG
ACAGACCTATGATGGAAAATGATCACGTCTCTGAATTTTTTCTTTAACGTTATAGTTCCTTATTACAGATAGTAAGCATATGGGAATTTC
TGAGCTATAACATGTTGAGAAGTTAGAAATTAAAACTAACACAACAAAAGGCGCTGAATCAAAAGATCTTTGCTTTTATTTGGCTCAGAA
TGTTTTTGGCTTTTCTGCTAAAGATGGCAGAAATTACTCTACACAGACCTGATTTTTCTTTATTGCAGACCATTCTTGTGGGCTTACCCT
GAGACTTTTATCCCAATTAGTGAATCTTGGAGGGAATACTTGCTTATTTATGACTTAGGTATTTCCCCCCAAACTTTAATATTCTTGAGC
ACTTGAAAATACTTTTGAGAAATTTTAACTGTGATTAAATTTAGGTTTATTAGAAATATTCTGTACACATTTGCCTCCATGGTGGCGTAA
GTTCTGAAAAATTATATGACCGTGACAATAGTTTATCATCATCATTATTGTTATTCAAAATAAGGGTAAATAAATCTCTGTATTGCCAAA
GTGACTTAAACTGTTCTGATGACCACACAGTGTGATTTCTTTAGCAGAGAAAGTTGGTTTTAAAAATAAATAGTACCACTTTTCTAAGAC
TGTACAGTTTACAAATAAGGTTTTTTTCTTTGTTGTTTTCCTCTTCTATTAAGTTTTAGTGAAAAGCCTAATTACAGAAAATTGTGCAGA
TACTAGTGAAGATACTAGTATAAGTTTAAAGGAACACGTGACTGTAAAATCTCACATTTACAAAGTGCTTGATCTCTTCATATTTCACAC
GCATGTTTTAGAATAGATTTTAGGGAGTGTTTAATTCATTATCCTTTTGACTTAAAATTTTTGTTACCAACTTCCTAGGACTTAGATAAT
ATATAAATAAGTACAAATCCCAGGGGAAGTGTTGTGATGCTAGACTAAAAGGTGGGAATGTGCTGCTGTTCCGTGAGCCTTGTTCCATTG
TTGAAAATTTGATGCCTCAGTGTTTATTCAGTACCACCTCATGGAGCTTCAATGTAAATGGATTATATGTATAATTGGTAATTTGTATAG
TTTTGTAGATTGTAGATTAAATGCACTCATCATGTCACATGTAATTGTGCTTGGAGTATTTGTGTTTTATTCTTTTACTTCAACGGGTTC
TTGTCTGTTACATCTCTGGTGATTTGAAATATCAGGAAAGACAGTTTGTCAGAAATGAGAATAATATAGTTGAAATCAGTTGGGCTAAAA
TATTCTACAGCAAGACAATTTCTTTTGGGTGAACTGATTCTATAATTTACTTACTTTTAATGTAAGGATTAGATTTATTGTTGAGCTGCT
TTCCAGATCAGACTGTCACTTTATAGTTTTTCTACATAAAGATTATATAGTTGCAAACAAAGGTTGTGAAATTTCCCTTTTGTTGTTTTT
GACTTTTAATTAATAAAAGTACATTGTTTTCATAGCAAA

>2668_2668_2_AFF1-U2SURP_AFF1_chr4_87869723_ENST00000395146_U2SURP_chr3_142751625_ENST00000473835_length(amino acids)=508AA_BP=15
METMAFTERVNSSGNRQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVAN
ASYYRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEE
ELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEE
ENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDK
LLQREKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSH
KDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNKH

--------------------------------------------------------------
>2668_2668_3_AFF1-U2SURP_AFF1_chr4_87869723_ENST00000395146_U2SURP_chr3_142751625_ENST00000493598_length(transcript)=2189nt_BP=313nt
GAGCTTGCCAGCCAGCTAGCGAGCGACGGGCGCGCGCGGCCCCTGCGCACTCGGCCGCCGCCTGCGCGCGTTGCGGCCGCAGCTGCACCT
TTGCCTCCGCGGTTCCGCAGCCGAGCCCCGGGAGGAGGCGCTCCCCTGCGTCGTCCGCACTTGCGCCCTTTCCCACCGCAACAGGTCAGG
GGAGGGCGGAGGTGACGAGGGCGCCCGACCCGGGACTAGAGGACGGAAGGGTCTGGAAGATGAACAGACTAGCCACTTTGCATTGACTGG
AAACAATGGCATTTACAGAAAGAGTCAACAGCAGTGGCAACAGACAGAGGGATAAATTGGAAGAAATCTTGCGGGGATTAACTCCAAGGA
AAAATGATATTGGAGATGCAATGGTTTTCTGTCTTAATAATGCTGAAGCTGCTGAAGAAATAGTGGATTGCATTACTGAGTCGTTGTCCA
TCTTAAAGACACCCCTTCCTAAAAAGATTGCCAGATTATATTTGGTTTCTGATGTTTTGTACAACTCTTCAGCCAAAGTTGCTAATGCTT
CATATTATAGAAAATTTTTTGAAACAAAGTTATGTCAGATATTTTCAGACCTCAATGCCACCTATCGTACAATTCAAGGCCATTTACAAT
CTGAAAACTTTAAGCAACGGGTAATGACTTGCTTCAGAGCATGGGAAGATTGGGCAATTTATCCAGAACCATTTTTGATCAAACTACAAA
ATATTTTCTTAGGACTTGTAAATATTATTGAAGAAAAGGAAACAGAGGATGTTCCAGATGACCTTGATGGTGCCCCCATCGAGGAAGAGC
TTGATGGTGCACCTCTGGAAGATGTAGATGGAATTCCTATTGATGCTACTCCCATCGATGATCTTGATGGAGTCCCTATAAAAAGTCTTG
ATGATGATCTTGATGGAGTGCCTTTGGATGCAACTGAAGACTCAAAAAAGAATGAGCCTATATTTAAAGTTGCCCCATCAAAATGGGAAG
CTGTGGATGAATCTGAATTGGAAGCACAGGCTGTTACAACTTCTAAATGGGAATTATTTGACCAGCATGAAGAATCAGAAGAAGAAGAAA
ATCAAAATCAAGAAGAAGAAAGTGAAGATGAAGAAGATACTCAAAGTTCCAAATCTGAAGAACATCATTTGTACTCTAATCCAATCAAAG
AAGAAATGACTGAGTCTAAGTTCTCTAAGTACTCTGAAATGAGTGAGGAAAAACGAGCCAAACTTCGTGAAATTGAGCTCAAAGTTATGA
AGTTTCAGGATGAATTGGAATCTGGGAAAAGACCTAAAAAACCAGGCCAGAGTTTTCAGGAGCAAGTAGAACACTACAGAGATAAACTTC
TTCAACGAGAGAAAGAGAAAGAGTTAGAAAGAGAACGAGAAAGAGACAAGAAAGATAAAGAAAAATTGGAATCTCGCTCCAAAGACAAGA
AGGAAAAAGATGAGTGTACTCCGACAAGGAAGGAAAGGAAGAGGCGACACAGTACATCCCCCAGCCCATCTCGCAGTAGCAGTGGTAGAC
GAGTGAAATCCCCATCACCAAAATCGGAGCGATCAGAGCGTTCAGAAAGATCTCATAAAGAGAGCTCACGGTCCAGGTCATCTCACAAAG
ATTCTCCTAGAGATGTTAGCAAAAAAGCCAAAAGATCACCATCTGGTTCAAGGACACCTAAAAGGTCTAGGCGATCACGGTCTAGATCTC
CTAAAAAATCAGGAAAGAAGTCCAGATCCCAGTCCAGATCTCCACACAGGTCTCATAAAAAGTCAAAGAAAAACAAACACTGACGTAAAT
TTTTAAGATGCTGTCACTTATTGGAAATGCGATTTGTTTTGTGCCTGAACGGTCTGTTTTTTAAAAAAACAAAAAATCAAATGAAAGAGC
ATTCCTGGGGTTTTTTGTTTGTTTGTGTATGCATGTGTAAACTCATGAGCAACTGCATCTGTAGATCTGTCATTGTTTTATATTGTGTAA
ATTACTTTCATTGTGGCTATTTCTCAAGATGAAATTTTTATTGTTCTAATGGATTTCATCAGAAATGTGTATAATGGATCTGCTGACAGT
AGTAGTATTTTGTTTTAGGATGTTGTGACTTAGCAAAAATAATACAGATGTCTTCCCCCCTTTTGTAGCTTTGACAATTTGAATTAGATT
TCAAATAAAATCTGAACAGAAAACTATAA

>2668_2668_3_AFF1-U2SURP_AFF1_chr4_87869723_ENST00000395146_U2SURP_chr3_142751625_ENST00000493598_length(amino acids)=508AA_BP=15
METMAFTERVNSSGNRQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVAN
ASYYRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEE
ELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEE
ENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDK
LLQREKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSH
KDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNKH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AFF1-U2SURP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AFF1-U2SURP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AFF1-U2SURP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human