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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:MMP14-MED23 (FusionGDB2 ID:HG4323TG9439) |
Fusion Gene Summary for MMP14-MED23 |
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Fusion gene information | Fusion gene name: MMP14-MED23 | Fusion gene ID: hg4323tg9439 | Hgene | Tgene | Gene symbol | MMP14 | MED23 | Gene ID | 4323 | 9439 |
Gene name | matrix metallopeptidase 14 | mediator complex subunit 23 | |
Synonyms | MMP-14|MMP-X1|MT-MMP|MT-MMP 1|MT1-MMP|MT1MMP|MTMMP1|WNCHRS | ARC130|CRSP130|CRSP133|CRSP3|DRIP130|MRT18|SUR-2|SUR2 | |
Cytomap | ('MMP14')('MED23') 14q11.2 | 6q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | matrix metalloproteinase-14matrix metallopeptidase 14 (membrane-inserted)membrane type 1 metalloproteasemembrane-type-1 matrix metalloproteinase | mediator of RNA polymerase II transcription subunit 23130 kDa transcriptional co-activator133 kDa transcriptional co-activatoractivator-recruited cofactor 130 kDa componentcofactor required for Sp1 transcriptional activation subunit 3mental retardati | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | P50281 | . | |
Ensembl transtripts involved in fusion gene | ENST00000548162, ENST00000311852, | ||
Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 4 X 6 X 3=72 |
# samples | 7 | 6 | |
** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MMP14 [Title/Abstract] AND MED23 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MMP14(23305858)-MED23(131908317), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MMP14 | GO:0006508 | proteolysis | 15863497|24970228 |
Hgene | MMP14 | GO:0030307 | positive regulation of cell growth | 22065321 |
Hgene | MMP14 | GO:0030335 | positive regulation of cell migration | 22065321 |
Hgene | MMP14 | GO:0031638 | zymogen activation | 20666777 |
Tgene | MED23 | GO:0006355 | regulation of transcription, DNA-templated | 9989412 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for MMP14-MED23 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MMP14-MED23 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for MMP14-MED23 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:23305858/:131908317) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
MMP14 | . |
FUNCTION: Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). {ECO:0000250|UniProtKB:P53690, ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:22330140}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MMP14-MED23 |
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Fusion Gene PPI Analysis for MMP14-MED23 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MMP14-MED23 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MMP14-MED23 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MMP14 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | MMP14 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
Hgene | MMP14 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | MMP14 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | MMP14 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
Hgene | MMP14 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | MMP14 | C0162871 | Aortic Aneurysm, Abdominal | 1 | CTD_human |
Hgene | MMP14 | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
Hgene | MMP14 | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
Hgene | MMP14 | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
Hgene | MMP14 | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
Hgene | MMP14 | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
Hgene | MMP14 | C0432289 | Winchester syndrome (disorder) | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | MMP14 | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
Hgene | MMP14 | C0678222 | Breast Carcinoma | 1 | CTD_human |
Hgene | MMP14 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
Hgene | MMP14 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | MMP14 | C1527303 | Chronic Airflow Obstruction | 1 | CTD_human |
Hgene | MMP14 | C2931456 | Prostate cancer, familial | 1 | CTD_human |
Hgene | MMP14 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
Hgene | MMP14 | C4722327 | PROSTATE CANCER, HEREDITARY, 1 | 1 | CTD_human |
Tgene | C3280265 | MENTAL RETARDATION, AUTOSOMAL RECESSIVE 18 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |