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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:MPO-ACSL1 (FusionGDB2 ID:HG4353TG2180) |
Fusion Gene Summary for MPO-ACSL1 |
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Fusion gene information | Fusion gene name: MPO-ACSL1 | Fusion gene ID: hg4353tg2180 | Hgene | Tgene | Gene symbol | MPO | ACSL1 | Gene ID | 4353 | 2180 |
Gene name | myeloperoxidase | acyl-CoA synthetase long chain family member 1 | |
Synonyms | - | ACS1|FACL1|FACL2|LACS|LACS1|LACS2 | |
Cytomap | ('MPO')('ACSL1') 17q22 | 4q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | myeloperoxidase | long-chain-fatty-acid--CoA ligase 1LACS 1LACS 2acyl-CoA synthetase 1arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 1fatty-acid-Coenzyme A ligase, long-chain 2lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 1long-chain acy | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | P05164 | . | |
Ensembl transtripts involved in fusion gene | ENST00000225275, ENST00000340482, ENST00000578493, | ||
Fusion gene scores | * DoF score | 9 X 6 X 2=108 | 3 X 3 X 3=27 |
# samples | 8 | 3 | |
** MAII score | log2(8/108*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MPO [Title/Abstract] AND ACSL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MPO(56355832)-ACSL1(185678233), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MPO | GO:0034374 | low-density lipoprotein particle remodeling | 10772654 |
Hgene | MPO | GO:0042744 | hydrogen peroxide catabolic process | 10772654|11907569 |
Hgene | MPO | GO:0055114 | oxidation-reduction process | 10772654 |
Tgene | ACSL1 | GO:0001676 | long-chain fatty acid metabolic process | 22022213|24269233 |
Tgene | ACSL1 | GO:0008610 | lipid biosynthetic process | 21242590 |
Tgene | ACSL1 | GO:0044539 | long-chain fatty acid import | 22022213 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for MPO-ACSL1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MPO-ACSL1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for MPO-ACSL1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:56355832/:185678233) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
MPO | . |
FUNCTION: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. {ECO:0000269|PubMed:9922160}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MPO-ACSL1 |
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Fusion Gene PPI Analysis for MPO-ACSL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MPO-ACSL1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | MPO | P05164 | DB00244 | Mesalazine | Small molecule | Approved | |
Hgene | MPO | P05164 | DB00535 | Cefdinir | Inhibitor | Small molecule | Approved |
Hgene | MPO | P05164 | DB00583 | Levocarnitine | Small molecule | Approved|Investigational | |
Hgene | MPO | P05164 | DB01065 | Melatonin | Inhibitor | Small molecule | Approved|Nutraceutical|Vet_approved |
Hgene | MPO | P05164 | DB04821 | Nomifensine | Small molecule | Approved|Withdrawn |
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Related Diseases for MPO-ACSL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MPO | C0035126 | Reperfusion Injury | 6 | CTD_human |
Hgene | MPO | C0021368 | Inflammation | 5 | CTD_human |
Hgene | MPO | C0398595 | Myeloperoxidase Deficiency | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | MPO | C0009324 | Ulcerative Colitis | 3 | CTD_human |
Hgene | MPO | C0003873 | Rheumatoid Arthritis | 2 | CTD_human |
Hgene | MPO | C0023891 | Liver Cirrhosis, Alcoholic | 2 | CTD_human |
Hgene | MPO | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
Hgene | MPO | C0002152 | Alloxan Diabetes | 1 | CTD_human |
Hgene | MPO | C0002395 | Alzheimer's Disease | 1 | CTD_human |
Hgene | MPO | C0003129 | Anoxemia | 1 | CTD_human |
Hgene | MPO | C0003130 | Anoxia | 1 | CTD_human |
Hgene | MPO | C0003865 | Arthritis, Adjuvant-Induced | 1 | CTD_human |
Hgene | MPO | C0005398 | Cholestasis, Extrahepatic | 1 | CTD_human |
Hgene | MPO | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
Hgene | MPO | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | MPO | C0006111 | Brain Diseases | 1 | CTD_human |
Hgene | MPO | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
Hgene | MPO | C0007786 | Brain Ischemia | 1 | CTD_human |
Hgene | MPO | C0009319 | Colitis | 1 | CTD_human |
Hgene | MPO | C0011265 | Presenile dementia | 1 | CTD_human |
Hgene | MPO | C0011574 | Involutional Depression | 1 | CTD_human |
Hgene | MPO | C0011609 | Drug Eruptions | 1 | CTD_human |
Hgene | MPO | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Hgene | MPO | C0022593 | Keratosis | 1 | CTD_human |
Hgene | MPO | C0022594 | Keratosis Blennorrhagica | 1 | CTD_human |
Hgene | MPO | C0022658 | Kidney Diseases | 1 | CTD_human |
Hgene | MPO | C0022660 | Kidney Failure, Acute | 1 | CTD_human |
Hgene | MPO | C0024115 | Lung diseases | 1 | CTD_human |
Hgene | MPO | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | MPO | C0028797 | Occupational Diseases | 1 | CTD_human |
Hgene | MPO | C0030305 | Pancreatitis | 1 | CTD_human |
Hgene | MPO | C0032927 | Precancerous Conditions | 1 | CTD_human |
Hgene | MPO | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | MPO | C0036982 | Shock, Hemorrhagic | 1 | CTD_human |
Hgene | MPO | C0038433 | Streptozotocin Diabetes | 1 | CTD_human |
Hgene | MPO | C0040954 | Infection by Trichuris trichiura | 1 | CTD_human |
Hgene | MPO | C0042109 | Urticaria | 1 | CTD_human |
Hgene | MPO | C0085584 | Encephalopathies | 1 | CTD_human |
Hgene | MPO | C0086501 | Keratoma | 1 | CTD_human |
Hgene | MPO | C0242184 | Hypoxia | 1 | CTD_human |
Hgene | MPO | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
Hgene | MPO | C0276496 | Familial Alzheimer Disease (FAD) | 1 | CTD_human |
Hgene | MPO | C0282313 | Condition, Preneoplastic | 1 | CTD_human |
Hgene | MPO | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | MPO | C0406537 | Morbilliform Drug Reaction | 1 | CTD_human |
Hgene | MPO | C0494463 | Alzheimer Disease, Late Onset | 1 | CTD_human |
Hgene | MPO | C0546126 | Acute Confusional Senile Dementia | 1 | CTD_human |
Hgene | MPO | C0700292 | Hypoxemia | 1 | CTD_human |
Hgene | MPO | C0750900 | Alzheimer's Disease, Focal Onset | 1 | CTD_human |
Hgene | MPO | C0750901 | Alzheimer Disease, Early Onset | 1 | CTD_human |
Hgene | MPO | C0917798 | Cerebral Ischemia | 1 | CTD_human |
Hgene | MPO | C0971858 | Arthritis, Collagen-Induced | 1 | CTD_human |
Hgene | MPO | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Hgene | MPO | C1269683 | Major Depressive Disorder | 1 | CTD_human |
Hgene | MPO | C1565662 | Acute Kidney Insufficiency | 1 | CTD_human |
Hgene | MPO | C1571983 | Involutional paraphrenia | 1 | CTD_human |
Hgene | MPO | C1571984 | Psychosis, Involutional | 1 | CTD_human |
Hgene | MPO | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | MPO | C2609414 | Acute kidney injury | 1 | CTD_human |
Tgene | C0002152 | Alloxan Diabetes | 1 | CTD_human | |
Tgene | C0003865 | Arthritis, Adjuvant-Induced | 1 | CTD_human | |
Tgene | C0007097 | Carcinoma | 1 | CTD_human | |
Tgene | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human | |
Tgene | C0019193 | Hepatitis, Toxic | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human | |
Tgene | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human | |
Tgene | C0028754 | Obesity | 1 | CTD_human | |
Tgene | C0038433 | Streptozotocin Diabetes | 1 | CTD_human | |
Tgene | C0205696 | Anaplastic carcinoma | 1 | CTD_human | |
Tgene | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human | |
Tgene | C0205698 | Undifferentiated carcinoma | 1 | CTD_human | |
Tgene | C0205699 | Carcinomatosis | 1 | CTD_human | |
Tgene | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human | |
Tgene | C0971858 | Arthritis, Collagen-Induced | 1 | CTD_human | |
Tgene | C0993582 | Arthritis, Experimental | 1 | CTD_human | |
Tgene | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human | |
Tgene | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human | |
Tgene | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human | |
Tgene | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human | |
Tgene | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |