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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ASMT-ANKDD1A (FusionGDB2 ID:HG438TG348094) |
Fusion Gene Summary for ASMT-ANKDD1A |
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Fusion gene information | Fusion gene name: ASMT-ANKDD1A | Fusion gene ID: hg438tg348094 | Hgene | Tgene | Gene symbol | ASMT | ANKDD1A | Gene ID | 438 | 348094 |
Gene name | acetylserotonin O-methyltransferase | ankyrin repeat and death domain containing 1A | |
Synonyms | ASMTY|HIOMT|HIOMTY | - | |
Cytomap | ('ASMT')('ANKDD1A') Xp22.33 and Yp11.2 | 15q22.31 | |
Type of gene | protein-coding | protein-coding | |
Description | acetylserotonin O-methyltransferaseacetylserotonin N-methyltransferaseacetylserotonin methyltransferase (Y chromosome)hydroxyindole O-methyltransferase | ankyrin repeat and death domain-containing protein 1A | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P46597 | Q495B1 | |
Ensembl transtripts involved in fusion gene | ENST00000381229, ENST00000381233, ENST00000381241, ENST00000509780, | ||
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 20 X 20 X 6=2400 |
# samples | 3 | 23 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(23/2400*10)=-3.38332863955151 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ASMT [Title/Abstract] AND ANKDD1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ASMT(1697965)-ANKDD1A(65244530), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ASMT | GO:0030187 | melatonin biosynthetic process | 22775292 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for ASMT-ANKDD1A |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ASMT-ANKDD1A |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ASMT-ANKDD1A |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1697965/:65244530) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ASMT | ANKDD1A |
FUNCTION: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. {ECO:0000269|PubMed:22775292}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ASMT-ANKDD1A |
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Fusion Gene PPI Analysis for ASMT-ANKDD1A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ASMT-ANKDD1A |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ASMT | P46597 | DB01065 | Melatonin | Small molecule | Approved|Nutraceutical|Vet_approved |
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Related Diseases for ASMT-ANKDD1A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ASMT | C0011570 | Mental Depression | 2 | PSYGENET |
Hgene | ASMT | C0011581 | Depressive disorder | 2 | PSYGENET |
Hgene | ASMT | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | ASMT | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | ASMT | C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
Hgene | ASMT | C1527352 | Hepatic Form of Wilson Disease | 1 | CTD_human |