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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:FAM66C-CACNA1C (FusionGDB2 ID:HG440078TG775) |
Fusion Gene Summary for FAM66C-CACNA1C |
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Fusion gene information | Fusion gene name: FAM66C-CACNA1C | Fusion gene ID: hg440078tg775 | Hgene | Tgene | Gene symbol | FAM66C | CACNA1C | Gene ID | 440078 | 775 |
Gene name | family with sequence similarity 66 member C | calcium voltage-gated channel subunit alpha1 C | |
Synonyms | - | CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS|TS. LQT8 | |
Cytomap | ('FAM66C')('CACNA1C') 12p13.31 | 12p13.33 | |
Type of gene | ncRNA | protein-coding | |
Description | - | voltage-dependent L-type calcium channel subunit alpha-1CDHPR, alpha-1 subunitcalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac musclecalcium channel, cardic dihydropyridine-sensitive, alpha-1 subunitcalcium channel, voltage-dependent, | |
Modification date | 20200313 | 20200315 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000454799, ENST00000456135, ENST00000541558, ENST00000544214, ENST00000372173, ENST00000420514, ENST00000438689, ENST00000535567, ENST00000540566, | ||
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 21 X 20 X 10=4200 |
# samples | 1 | 24 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(24/4200*10)=-4.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FAM66C [Title/Abstract] AND CACNA1C [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FAM66C(8333348)-CACNA1C(2224390), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CACNA1C | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 12130699 |
Tgene | CACNA1C | GO:0061577 | calcium ion transmembrane transport via high voltage-gated calcium channel | 15454078 |
Tgene | CACNA1C | GO:0070588 | calcium ion transmembrane transport | 15454078 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PRAD | TCGA-CH-5792 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
Top |
Fusion Gene ORF analysis for FAM66C-CACNA1C |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000454799 | ENST00000327702 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000335762 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000344100 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000347598 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399591 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399595 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399597 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399601 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399603 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399606 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399617 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399621 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399629 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399634 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399637 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399638 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399641 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399644 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399649 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000399655 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000402845 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000406454 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000454799 | ENST00000480911 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000327702 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000335762 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000344100 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000347598 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399591 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399595 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399597 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399601 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399603 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399606 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399617 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399621 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399629 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399634 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399637 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399638 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399641 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399644 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399649 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000399655 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000402845 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000406454 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000456135 | ENST00000480911 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000327702 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000335762 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000344100 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000347598 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399591 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399595 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399597 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399601 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399603 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399606 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399617 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399621 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399629 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399634 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399637 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399638 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399641 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399644 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399649 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000399655 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000402845 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000406454 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000541558 | ENST00000480911 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000327702 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000335762 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000344100 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000347598 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399591 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399595 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399597 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399601 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399603 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399606 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399617 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399621 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399629 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399634 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399637 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399638 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399641 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399644 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399649 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000399655 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000402845 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000406454 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-3CDS | ENST00000544214 | ENST00000480911 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-intron | ENST00000454799 | ENST00000491104 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-intron | ENST00000456135 | ENST00000491104 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-intron | ENST00000541558 | ENST00000491104 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
3UTR-intron | ENST00000544214 | ENST00000491104 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000327702 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000335762 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000344100 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000347598 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399591 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399595 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399597 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399601 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399603 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399606 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399617 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399621 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399629 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399634 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399637 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399638 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399641 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399644 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399649 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000399655 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000402845 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000406454 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000372173 | ENST00000480911 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000327702 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000335762 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000344100 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000347598 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399591 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399595 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399597 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399601 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399603 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399606 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399617 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399621 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399629 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399634 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399637 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399638 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399641 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399644 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399649 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000399655 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000402845 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000406454 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000420514 | ENST00000480911 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000327702 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000335762 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000344100 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000347598 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399591 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399595 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399597 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399601 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399603 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399606 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399617 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399621 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399629 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399634 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399637 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399638 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399641 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399644 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399649 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000399655 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000402845 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000406454 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000438689 | ENST00000480911 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000327702 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000335762 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000344100 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000347598 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399591 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399595 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399597 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399601 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399603 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399606 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399617 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399621 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399629 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399634 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399637 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399638 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399641 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399644 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399649 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000399655 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000402845 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000406454 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000535567 | ENST00000480911 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000327702 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000335762 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000344100 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000347598 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399591 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399595 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399597 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399601 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399603 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399606 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399617 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399621 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399629 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399634 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399637 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399638 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399641 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399644 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399649 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000399655 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000402845 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000406454 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-3CDS | ENST00000540566 | ENST00000480911 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-intron | ENST00000372173 | ENST00000491104 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-intron | ENST00000420514 | ENST00000491104 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-intron | ENST00000438689 | ENST00000491104 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-intron | ENST00000535567 | ENST00000491104 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
intron-intron | ENST00000540566 | ENST00000491104 | FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224390 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FAM66C-CACNA1C |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224389 | + | 0.002150152 | 0.9978498 |
FAM66C | chr12 | 8333348 | + | CACNA1C | chr12 | 2224389 | + | 0.002150152 | 0.9978498 |
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Fusion Protein Features for FAM66C-CACNA1C |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:8333348/:2224390) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FAM66C-CACNA1C |
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Fusion Gene PPI Analysis for FAM66C-CACNA1C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FAM66C-CACNA1C |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FAM66C-CACNA1C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0005586 | Bipolar Disorder | 9 | CTD_human;PSYGENET | |
Tgene | C1832916 | Timothy syndrome | 8 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C1142166 | Brugada Syndrome (disorder) | 7 | CLINGEN;GENOMICS_ENGLAND | |
Tgene | C1269683 | Major Depressive Disorder | 6 | CTD_human;PSYGENET | |
Tgene | C0011570 | Mental Depression | 5 | PSYGENET | |
Tgene | C0011581 | Depressive disorder | 5 | PSYGENET | |
Tgene | C0041696 | Unipolar Depression | 5 | PSYGENET | |
Tgene | C0525045 | Mood Disorders | 5 | PSYGENET | |
Tgene | C2678478 | Brugada Syndrome 3 | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0005587 | Depression, Bipolar | 4 | CTD_human | |
Tgene | C0024713 | Manic Disorder | 4 | CTD_human | |
Tgene | C0036341 | Schizophrenia | 4 | PSYGENET | |
Tgene | C0338831 | Manic | 4 | CTD_human | |
Tgene | C0033975 | Psychotic Disorders | 3 | PSYGENET | |
Tgene | C0178417 | Anhedonia | 2 | PSYGENET | |
Tgene | C0002895 | Anemia, Sickle Cell | 1 | GENOMICS_ENGLAND | |
Tgene | C0003257 | Antibody Deficiency Syndrome | 1 | CTD_human | |
Tgene | C0003469 | Anxiety Disorders | 1 | CTD_human | |
Tgene | C0003811 | Cardiac Arrhythmia | 1 | CTD_human | |
Tgene | C0004352 | Autistic Disorder | 1 | CTD_human | |
Tgene | C0007194 | Hypertrophic Cardiomyopathy | 1 | GENOMICS_ENGLAND | |
Tgene | C0011574 | Involutional Depression | 1 | CTD_human | |
Tgene | C0020538 | Hypertensive disease | 1 | CTD_human | |
Tgene | C0020615 | Hypoglycemia | 1 | CTD_human | |
Tgene | C0021051 | Immunologic Deficiency Syndromes | 1 | CTD_human | |
Tgene | C0038441 | Stress Disorders, Traumatic | 1 | CTD_human | |
Tgene | C0039070 | Syncope | 1 | GENOMICS_ENGLAND | |
Tgene | C0085298 | Sudden Cardiac Death | 1 | GENOMICS_ENGLAND | |
Tgene | C0151879 | Shortened QT interval | 1 | GENOMICS_ENGLAND | |
Tgene | C0206762 | Limb Deformities, Congenital | 1 | CTD_human | |
Tgene | C0234985 | Mental deterioration | 1 | CTD_human | |
Tgene | C0271708 | Fasting Hypoglycemia | 1 | CTD_human | |
Tgene | C0271710 | Reactive hypoglycemia | 1 | CTD_human | |
Tgene | C0338656 | Impaired cognition | 1 | CTD_human | |
Tgene | C0342788 | Renal carnitine transport defect | 1 | GENOMICS_ENGLAND | |
Tgene | C0349204 | Nonorganic psychosis | 1 | PSYGENET | |
Tgene | C0376280 | Anxiety States, Neurotic | 1 | CTD_human | |
Tgene | C0392156 | Akathisia | 1 | CTD_human | |
Tgene | C1270972 | Mild cognitive disorder | 1 | CTD_human | |
Tgene | C1279420 | Anxiety neurosis (finding) | 1 | CTD_human | |
Tgene | C1571983 | Involutional paraphrenia | 1 | CTD_human | |
Tgene | C1571984 | Psychosis, Involutional | 1 | CTD_human | |
Tgene | C3887612 | Psychomotor Agitation | 1 | CTD_human |