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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:C5orf56-COMMD6 (FusionGDB2 ID:HG441108TG170622)

Fusion Gene Summary for C5orf56-COMMD6

check button Fusion gene summary
Fusion gene informationFusion gene name: C5orf56-COMMD6
Fusion gene ID: hg441108tg170622
HgeneTgene
Gene symbol

C5orf56

COMMD6

Gene ID

441108

170622

Gene nameIRF1 antisense RNA 1COMM domain containing 6
SynonymsC5orf56Acrg
Cytomap('C5orf56')('COMMD6')

5q31.1

13q22.2

Type of genencRNAprotein-coding
Descriptionuncharacterized protein C5orf56COMM domain-containing protein 6Acrg embryonic lethality minimal region ortholog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000337752, ENST00000378947, 
ENST00000378953, ENST00000407797, 
ENST00000464024, 
Fusion gene scores* DoF score5 X 2 X 4=405 X 7 X 4=140
# samples 76
** MAII scorelog2(7/40*10)=0.807354922057604
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C5orf56 [Title/Abstract] AND COMMD6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC5orf56(131785381)-COMMD6(76100775), # samples:1
Anticipated loss of major functional domain due to fusion event.C5orf56-COMMD6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C5orf56-COMMD6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C5orf56-COMMD6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOMMD6

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16573520


check buttonFusion gene breakpoints across C5orf56 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across COMMD6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8210-01AC5orf56chr5

131785381

+COMMD6chr13

76100775

-


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Fusion Gene ORF analysis for C5orf56-COMMD6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000337752ENST00000460675C5orf56chr5

131785381

+COMMD6chr13

76100775

-
5CDS-5UTRENST00000378947ENST00000460675C5orf56chr5

131785381

+COMMD6chr13

76100775

-
5CDS-5UTRENST00000378953ENST00000460675C5orf56chr5

131785381

+COMMD6chr13

76100775

-
5CDS-5UTRENST00000407797ENST00000460675C5orf56chr5

131785381

+COMMD6chr13

76100775

-
Frame-shiftENST00000337752ENST00000355801C5orf56chr5

131785381

+COMMD6chr13

76100775

-
Frame-shiftENST00000337752ENST00000377615C5orf56chr5

131785381

+COMMD6chr13

76100775

-
Frame-shiftENST00000378947ENST00000355801C5orf56chr5

131785381

+COMMD6chr13

76100775

-
Frame-shiftENST00000378947ENST00000377615C5orf56chr5

131785381

+COMMD6chr13

76100775

-
Frame-shiftENST00000378953ENST00000355801C5orf56chr5

131785381

+COMMD6chr13

76100775

-
Frame-shiftENST00000378953ENST00000377615C5orf56chr5

131785381

+COMMD6chr13

76100775

-
Frame-shiftENST00000407797ENST00000355801C5orf56chr5

131785381

+COMMD6chr13

76100775

-
Frame-shiftENST00000407797ENST00000377615C5orf56chr5

131785381

+COMMD6chr13

76100775

-
In-frameENST00000337752ENST00000377619C5orf56chr5

131785381

+COMMD6chr13

76100775

-
In-frameENST00000337752ENST00000406936C5orf56chr5

131785381

+COMMD6chr13

76100775

-
In-frameENST00000378947ENST00000377619C5orf56chr5

131785381

+COMMD6chr13

76100775

-
In-frameENST00000378947ENST00000406936C5orf56chr5

131785381

+COMMD6chr13

76100775

-
In-frameENST00000378953ENST00000377619C5orf56chr5

131785381

+COMMD6chr13

76100775

-
In-frameENST00000378953ENST00000406936C5orf56chr5

131785381

+COMMD6chr13

76100775

-
In-frameENST00000407797ENST00000377619C5orf56chr5

131785381

+COMMD6chr13

76100775

-
In-frameENST00000407797ENST00000406936C5orf56chr5

131785381

+COMMD6chr13

76100775

-
intron-3CDSENST00000464024ENST00000355801C5orf56chr5

131785381

+COMMD6chr13

76100775

-
intron-3CDSENST00000464024ENST00000377615C5orf56chr5

131785381

+COMMD6chr13

76100775

-
intron-3CDSENST00000464024ENST00000377619C5orf56chr5

131785381

+COMMD6chr13

76100775

-
intron-3CDSENST00000464024ENST00000406936C5orf56chr5

131785381

+COMMD6chr13

76100775

-
intron-5UTRENST00000464024ENST00000460675C5orf56chr5

131785381

+COMMD6chr13

76100775

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378953C5orf56chr5131785381+ENST00000406936COMMD6chr1376100775-199056432604190
ENST00000378953C5orf56chr5131785381+ENST00000377619COMMD6chr1376100775-76856432604190
ENST00000337752C5orf56chr5131785381+ENST00000406936COMMD6chr1376100775-16452193890130
ENST00000337752C5orf56chr5131785381+ENST00000377619COMMD6chr1376100775-4232193890130
ENST00000378947C5orf56chr5131785381+ENST00000406936COMMD6chr1376100775-16372113811127
ENST00000378947C5orf56chr5131785381+ENST00000377619COMMD6chr1376100775-4152113811127
ENST00000407797C5orf56chr5131785381+ENST00000406936COMMD6chr1376100775-16372113811127
ENST00000407797C5orf56chr5131785381+ENST00000377619COMMD6chr1376100775-4152113811127

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378953ENST00000406936C5orf56chr5131785381+COMMD6chr1376100775-0.757426860.24257314
ENST00000378953ENST00000377619C5orf56chr5131785381+COMMD6chr1376100775-0.860621630.13937841
ENST00000337752ENST00000406936C5orf56chr5131785381+COMMD6chr1376100775-0.592529060.40747094
ENST00000337752ENST00000377619C5orf56chr5131785381+COMMD6chr1376100775-0.70084360.2991564
ENST00000378947ENST00000406936C5orf56chr5131785381+COMMD6chr1376100775-0.63171680.36828318
ENST00000378947ENST00000377619C5orf56chr5131785381+COMMD6chr1376100775-0.76221740.23778263
ENST00000407797ENST00000406936C5orf56chr5131785381+COMMD6chr1376100775-0.63171680.36828318
ENST00000407797ENST00000377619C5orf56chr5131785381+COMMD6chr1376100775-0.76221740.23778263

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Fusion Genomic Features for C5orf56-COMMD6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C5orf56-COMMD6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:131785381/chr13:76100775)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOMMD6chr5:131785381chr13:76100775ENST000003558013518_858299.0DomainCOMM
TgeneCOMMD6chr5:131785381chr13:76100775ENST000003776153518_856986.0DomainCOMM
TgeneCOMMD6chr5:131785381chr13:76100775ENST000004069362418_856986.0DomainCOMM


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Fusion Gene Sequence for C5orf56-COMMD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11879_11879_1_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000337752_COMMD6_chr13_76100775_ENST00000377619_length(transcript)=423nt_BP=219nt
AGAATGCAGCGGCCGCCAGCCTGGAGCGCGGGCCCTGGGGCCGCAACCCGCGCCGGGCGAGGTGGCAGCACACCCTGGGCCCCCCACTCC
CCGCCGCAAGTCCTGAGGATGGCCAGCAGAGAAACAAGAAAATGGACTCCCTGGCTGCTGGAGAGTTGAATGCCAGCCACCAGCCATGGG
TGCCAGAGTTTGTAGCCTATTGGAGGAAAACACACCAAGAATTTCTACAGACAGTTCAAGGAAATTGCTGCAGTTATTGAAACGGTGTGA
AGACGGATTCTTTGGTTGATAAATTGCTATCATTCTAAAGTCATGGACTTCACTTTCGGCAACAAAACTAAATAAGGATGGAACATTTAT

>11879_11879_1_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000337752_COMMD6_chr13_76100775_ENST00000377619_length(amino acids)=130AA_BP=0
MEKQKCIFHSINVPSLFSFVAESEVHDFRMIAIYQPKNPSSHRFNNCSNFLELSVEILGVFSSNRLQTLAPMAGGWHSTLQQPGSPFSCF

--------------------------------------------------------------
>11879_11879_2_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000337752_COMMD6_chr13_76100775_ENST00000406936_length(transcript)=1645nt_BP=219nt
AGAATGCAGCGGCCGCCAGCCTGGAGCGCGGGCCCTGGGGCCGCAACCCGCGCCGGGCGAGGTGGCAGCACACCCTGGGCCCCCCACTCC
CCGCCGCAAGTCCTGAGGATGGCCAGCAGAGAAACAAGAAAATGGACTCCCTGGCTGCTGGAGAGTTGAATGCCAGCCACCAGCCATGGG
TGCCAGAGTTTGTAGCCTATTGGAGGAAAACACACCAAGAATTTCTACAGACAGTTCAAGGAAATTGCTGCAGTTATTGAAACGGTGTGA
AGACGGATTCTTTGGTTGATAAATTGCTATCATTCTAAAGTCATGGACTTCACTTTCGGCAACAAAACTAAATAAGGATGGAACATTTAT
TGAATGAAAAATGCACTTTTGTTTTTCCATTTTTTTAAATAATAAAAATCAGACAAACAGGAACTGGGTAGTGGTGATGAATGCAAAACT
TTGTGAATGTGCTTTATAAAAGTGATAATTAGACACTTTAGAGGATATACTTGGTGATAATGTGAATGATGTAATCAGACTAACAGTTGA
ATCATTGCTGTTGGAGGCAGCACAAATTTATGTGTTACAACAGTAGTTTAAAAACTTGTACTGGATGGAACCCATTTTATAAACAGTCTT
ATTTGGAGTCATGTATATAAAAATATATATAAATTAGAAAAGTAGTATTTGATTAGGATAACTTTACAAATTCAATAGTATAGCCATCAC
TTATTATAATGGCAATCAGAAGAGTGAGGCTTCTTTTTTCAAACTTTTGTAATCAGATTAAGATTGACCATTGCTCCTTTACACAGTATT
AGTCTAGCATTCAATTATTTCTGTTATTAATGGTTGTAGAAAGTTCAAATACATACGCAGAGTTGGAAAGACGAGTTTTAGTCTGAGTTC
TGTACGACGGAGTTAACCCGTTAGCACAAGTTATTGCATTAGATGATCTCTGTTGAATTTAAATACATAAACCTGTTGTTAAACGCTTTT
ATACTATAAAGCCACCACATTGTATGGCATTTGTTTAGAAGTAAGCAAATAGACCACCGGAATAGAATAGATGGCCTAGAAATAGATCAA
GACATTCTGGTCCGCCATATTAGAAATTTAAACCCTCTTCACACCCTGTCTGCATTTCTGCAGGTCTGTGTGAGTCCACTTTCTTTTTTG
TTCCCTGCTAGGTAGCACACAGCTGTGAGGAGCCCAGGACTGCTGCCTGCCGCAGCCCACCTGTGCGCTCAGATTCCTACCAGCTTGATG
AGTTAGCTGATGGGCCATTTGTGCATACCAACTACCCACAGACATTTCTATTACCCACCCTCTGGATGCCAGTGCATTAATGATTCTAGA
ATTAGGAGAAACCAAAGATCCCTTCTCTCTCCCTCCCACAACCAGTGTCGTCGTGTTCCTAGAAATAAGAGTAGAAACCCCTCTATCTGG
GTTAAAACAGCAAACCTGCCTTCTGTAACTGTGCATGAGGTTCCTCTGTCTCCCACTTACTTCGGATTAACACCTTCCTCTTTCCCCTTC
CCTGTTTGCAGGGTAGCATTTCTAGGTTTAAGGCAATATGCAAAAAGACCCAAAGTTAGGCCCTGGCTCAAACACTGTGGGTAGCAGATT

>11879_11879_2_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000337752_COMMD6_chr13_76100775_ENST00000406936_length(amino acids)=130AA_BP=0
MEKQKCIFHSINVPSLFSFVAESEVHDFRMIAIYQPKNPSSHRFNNCSNFLELSVEILGVFSSNRLQTLAPMAGGWHSTLQQPGSPFSCF

--------------------------------------------------------------
>11879_11879_3_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000378947_COMMD6_chr13_76100775_ENST00000377619_length(transcript)=415nt_BP=211nt
GCGGCCGCCAGCCTGGAGCGCGGGCCCTGGGGCCGCAACCCGCGCCGGGCGAGGTGGCAGCACACCCTGGGCCCCCCACTCCCCGCCGCA
AGTCCTGAGGATGGCCAGCAGAGAAACAAGAAAATGGACTCCCTGGCTGCTGGAGAGTTGAATGCCAGCCACCAGCCATGGGTGCCAGAG
TTTGTAGCCTATTGGAGGAAAACACACCAAGAATTTCTACAGACAGTTCAAGGAAATTGCTGCAGTTATTGAAACGGTGTGAAGACGGAT
TCTTTGGTTGATAAATTGCTATCATTCTAAAGTCATGGACTTCACTTTCGGCAACAAAACTAAATAAGGATGGAACATTTATTGAATGAA

>11879_11879_3_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000378947_COMMD6_chr13_76100775_ENST00000377619_length(amino acids)=127AA_BP=0
MEKQKCIFHSINVPSLFSFVAESEVHDFRMIAIYQPKNPSSHRFNNCSNFLELSVEILGVFSSNRLQTLAPMAGGWHSTLQQPGSPFSCF

--------------------------------------------------------------
>11879_11879_4_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000378947_COMMD6_chr13_76100775_ENST00000406936_length(transcript)=1637nt_BP=211nt
GCGGCCGCCAGCCTGGAGCGCGGGCCCTGGGGCCGCAACCCGCGCCGGGCGAGGTGGCAGCACACCCTGGGCCCCCCACTCCCCGCCGCA
AGTCCTGAGGATGGCCAGCAGAGAAACAAGAAAATGGACTCCCTGGCTGCTGGAGAGTTGAATGCCAGCCACCAGCCATGGGTGCCAGAG
TTTGTAGCCTATTGGAGGAAAACACACCAAGAATTTCTACAGACAGTTCAAGGAAATTGCTGCAGTTATTGAAACGGTGTGAAGACGGAT
TCTTTGGTTGATAAATTGCTATCATTCTAAAGTCATGGACTTCACTTTCGGCAACAAAACTAAATAAGGATGGAACATTTATTGAATGAA
AAATGCACTTTTGTTTTTCCATTTTTTTAAATAATAAAAATCAGACAAACAGGAACTGGGTAGTGGTGATGAATGCAAAACTTTGTGAAT
GTGCTTTATAAAAGTGATAATTAGACACTTTAGAGGATATACTTGGTGATAATGTGAATGATGTAATCAGACTAACAGTTGAATCATTGC
TGTTGGAGGCAGCACAAATTTATGTGTTACAACAGTAGTTTAAAAACTTGTACTGGATGGAACCCATTTTATAAACAGTCTTATTTGGAG
TCATGTATATAAAAATATATATAAATTAGAAAAGTAGTATTTGATTAGGATAACTTTACAAATTCAATAGTATAGCCATCACTTATTATA
ATGGCAATCAGAAGAGTGAGGCTTCTTTTTTCAAACTTTTGTAATCAGATTAAGATTGACCATTGCTCCTTTACACAGTATTAGTCTAGC
ATTCAATTATTTCTGTTATTAATGGTTGTAGAAAGTTCAAATACATACGCAGAGTTGGAAAGACGAGTTTTAGTCTGAGTTCTGTACGAC
GGAGTTAACCCGTTAGCACAAGTTATTGCATTAGATGATCTCTGTTGAATTTAAATACATAAACCTGTTGTTAAACGCTTTTATACTATA
AAGCCACCACATTGTATGGCATTTGTTTAGAAGTAAGCAAATAGACCACCGGAATAGAATAGATGGCCTAGAAATAGATCAAGACATTCT
GGTCCGCCATATTAGAAATTTAAACCCTCTTCACACCCTGTCTGCATTTCTGCAGGTCTGTGTGAGTCCACTTTCTTTTTTGTTCCCTGC
TAGGTAGCACACAGCTGTGAGGAGCCCAGGACTGCTGCCTGCCGCAGCCCACCTGTGCGCTCAGATTCCTACCAGCTTGATGAGTTAGCT
GATGGGCCATTTGTGCATACCAACTACCCACAGACATTTCTATTACCCACCCTCTGGATGCCAGTGCATTAATGATTCTAGAATTAGGAG
AAACCAAAGATCCCTTCTCTCTCCCTCCCACAACCAGTGTCGTCGTGTTCCTAGAAATAAGAGTAGAAACCCCTCTATCTGGGTTAAAAC
AGCAAACCTGCCTTCTGTAACTGTGCATGAGGTTCCTCTGTCTCCCACTTACTTCGGATTAACACCTTCCTCTTTCCCCTTCCCTGTTTG
CAGGGTAGCATTTCTAGGTTTAAGGCAATATGCAAAAAGACCCAAAGTTAGGCCCTGGCTCAAACACTGTGGGTAGCAGATTTGAAATAA

>11879_11879_4_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000378947_COMMD6_chr13_76100775_ENST00000406936_length(amino acids)=127AA_BP=0
MEKQKCIFHSINVPSLFSFVAESEVHDFRMIAIYQPKNPSSHRFNNCSNFLELSVEILGVFSSNRLQTLAPMAGGWHSTLQQPGSPFSCF

--------------------------------------------------------------
>11879_11879_5_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000378953_COMMD6_chr13_76100775_ENST00000377619_length(transcript)=768nt_BP=564nt
GCGCCGCGGGCGCCTTTCCACTTACGGCGGGCCTGCCCAGCCTCCCGCCCAGCCCGGGCCCGGGTCCCGCCGAGGCAGGTGTGCGTGGCG
GACTAGCTCTCGGGCACTCGGCTGGCCCAGCTCCACCCCGAACGCCACCGGGCCAGGCCACGCGCAGACCCGAGCCCGGGGCCCCCGCCT
CTGGCTGCCGGCCCGCGCCCGCCGCGCGCCCCGCGTTCACTGCGCGCTCGGCCCCGGTCCCGCCTCCCGGAGGGTTTCGCTTTCGCTTTC
CTGCCGATGTCGTTGAGGAAAATGAAAGCGGTCGTGGCCAGGACTGGCGCAGCTGCCGTTTCAGGCGAGGGGCGCAGAATGCAGCGGCCG
CCAGCCTGGAGCGCGGGCCCTGGGGCCGCAACCCGCGCCGGGCGAGGTGGCAGCACACCCTGGGCCCCCCACTCCCCGCCGCAAGTCCTG
AGGATGGCCAGCAGAGAAACAAGAAAATGGACTCCCTGGCTGCTGGAGAGTTGAATGCCAGCCACCAGCCATGGGTGCCAGAGTTTGTAG
CCTATTGGAGGAAAACACACCAAGAATTTCTACAGACAGTTCAAGGAAATTGCTGCAGTTATTGAAACGGTGTGAAGACGGATTCTTTGG
TTGATAAATTGCTATCATTCTAAAGTCATGGACTTCACTTTCGGCAACAAAACTAAATAAGGATGGAACATTTATTGAATGAAAAATGCA

>11879_11879_5_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000378953_COMMD6_chr13_76100775_ENST00000377619_length(amino acids)=190AA_BP=
MPSLPPSPGPGPAEAGVRGGLALGHSAGPAPPRTPPGQATRRPEPGAPASGCRPAPAARPAFTARSAPVPPPGGFRFRFPADVVEENESG
RGQDWRSCRFRRGAQNAAAASLERGPWGRNPRRARWQHTLGPPLPAASPEDGQQRNKKMDSLAAGELNASHQPWVPEFVAYWRKTHQEFL

--------------------------------------------------------------
>11879_11879_6_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000378953_COMMD6_chr13_76100775_ENST00000406936_length(transcript)=1990nt_BP=564nt
GCGCCGCGGGCGCCTTTCCACTTACGGCGGGCCTGCCCAGCCTCCCGCCCAGCCCGGGCCCGGGTCCCGCCGAGGCAGGTGTGCGTGGCG
GACTAGCTCTCGGGCACTCGGCTGGCCCAGCTCCACCCCGAACGCCACCGGGCCAGGCCACGCGCAGACCCGAGCCCGGGGCCCCCGCCT
CTGGCTGCCGGCCCGCGCCCGCCGCGCGCCCCGCGTTCACTGCGCGCTCGGCCCCGGTCCCGCCTCCCGGAGGGTTTCGCTTTCGCTTTC
CTGCCGATGTCGTTGAGGAAAATGAAAGCGGTCGTGGCCAGGACTGGCGCAGCTGCCGTTTCAGGCGAGGGGCGCAGAATGCAGCGGCCG
CCAGCCTGGAGCGCGGGCCCTGGGGCCGCAACCCGCGCCGGGCGAGGTGGCAGCACACCCTGGGCCCCCCACTCCCCGCCGCAAGTCCTG
AGGATGGCCAGCAGAGAAACAAGAAAATGGACTCCCTGGCTGCTGGAGAGTTGAATGCCAGCCACCAGCCATGGGTGCCAGAGTTTGTAG
CCTATTGGAGGAAAACACACCAAGAATTTCTACAGACAGTTCAAGGAAATTGCTGCAGTTATTGAAACGGTGTGAAGACGGATTCTTTGG
TTGATAAATTGCTATCATTCTAAAGTCATGGACTTCACTTTCGGCAACAAAACTAAATAAGGATGGAACATTTATTGAATGAAAAATGCA
CTTTTGTTTTTCCATTTTTTTAAATAATAAAAATCAGACAAACAGGAACTGGGTAGTGGTGATGAATGCAAAACTTTGTGAATGTGCTTT
ATAAAAGTGATAATTAGACACTTTAGAGGATATACTTGGTGATAATGTGAATGATGTAATCAGACTAACAGTTGAATCATTGCTGTTGGA
GGCAGCACAAATTTATGTGTTACAACAGTAGTTTAAAAACTTGTACTGGATGGAACCCATTTTATAAACAGTCTTATTTGGAGTCATGTA
TATAAAAATATATATAAATTAGAAAAGTAGTATTTGATTAGGATAACTTTACAAATTCAATAGTATAGCCATCACTTATTATAATGGCAA
TCAGAAGAGTGAGGCTTCTTTTTTCAAACTTTTGTAATCAGATTAAGATTGACCATTGCTCCTTTACACAGTATTAGTCTAGCATTCAAT
TATTTCTGTTATTAATGGTTGTAGAAAGTTCAAATACATACGCAGAGTTGGAAAGACGAGTTTTAGTCTGAGTTCTGTACGACGGAGTTA
ACCCGTTAGCACAAGTTATTGCATTAGATGATCTCTGTTGAATTTAAATACATAAACCTGTTGTTAAACGCTTTTATACTATAAAGCCAC
CACATTGTATGGCATTTGTTTAGAAGTAAGCAAATAGACCACCGGAATAGAATAGATGGCCTAGAAATAGATCAAGACATTCTGGTCCGC
CATATTAGAAATTTAAACCCTCTTCACACCCTGTCTGCATTTCTGCAGGTCTGTGTGAGTCCACTTTCTTTTTTGTTCCCTGCTAGGTAG
CACACAGCTGTGAGGAGCCCAGGACTGCTGCCTGCCGCAGCCCACCTGTGCGCTCAGATTCCTACCAGCTTGATGAGTTAGCTGATGGGC
CATTTGTGCATACCAACTACCCACAGACATTTCTATTACCCACCCTCTGGATGCCAGTGCATTAATGATTCTAGAATTAGGAGAAACCAA
AGATCCCTTCTCTCTCCCTCCCACAACCAGTGTCGTCGTGTTCCTAGAAATAAGAGTAGAAACCCCTCTATCTGGGTTAAAACAGCAAAC
CTGCCTTCTGTAACTGTGCATGAGGTTCCTCTGTCTCCCACTTACTTCGGATTAACACCTTCCTCTTTCCCCTTCCCTGTTTGCAGGGTA
GCATTTCTAGGTTTAAGGCAATATGCAAAAAGACCCAAAGTTAGGCCCTGGCTCAAACACTGTGGGTAGCAGATTTGAAATAAATTTAAA

>11879_11879_6_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000378953_COMMD6_chr13_76100775_ENST00000406936_length(amino acids)=190AA_BP=
MPSLPPSPGPGPAEAGVRGGLALGHSAGPAPPRTPPGQATRRPEPGAPASGCRPAPAARPAFTARSAPVPPPGGFRFRFPADVVEENESG
RGQDWRSCRFRRGAQNAAAASLERGPWGRNPRRARWQHTLGPPLPAASPEDGQQRNKKMDSLAAGELNASHQPWVPEFVAYWRKTHQEFL

--------------------------------------------------------------
>11879_11879_7_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000407797_COMMD6_chr13_76100775_ENST00000377619_length(transcript)=415nt_BP=211nt
GCGGCCGCCAGCCTGGAGCGCGGGCCCTGGGGCCGCAACCCGCGCCGGGCGAGGTGGCAGCACACCCTGGGCCCCCCACTCCCCGCCGCA
AGTCCTGAGGATGGCCAGCAGAGAAACAAGAAAATGGACTCCCTGGCTGCTGGAGAGTTGAATGCCAGCCACCAGCCATGGGTGCCAGAG
TTTGTAGCCTATTGGAGGAAAACACACCAAGAATTTCTACAGACAGTTCAAGGAAATTGCTGCAGTTATTGAAACGGTGTGAAGACGGAT
TCTTTGGTTGATAAATTGCTATCATTCTAAAGTCATGGACTTCACTTTCGGCAACAAAACTAAATAAGGATGGAACATTTATTGAATGAA

>11879_11879_7_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000407797_COMMD6_chr13_76100775_ENST00000377619_length(amino acids)=127AA_BP=0
MEKQKCIFHSINVPSLFSFVAESEVHDFRMIAIYQPKNPSSHRFNNCSNFLELSVEILGVFSSNRLQTLAPMAGGWHSTLQQPGSPFSCF

--------------------------------------------------------------
>11879_11879_8_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000407797_COMMD6_chr13_76100775_ENST00000406936_length(transcript)=1637nt_BP=211nt
GCGGCCGCCAGCCTGGAGCGCGGGCCCTGGGGCCGCAACCCGCGCCGGGCGAGGTGGCAGCACACCCTGGGCCCCCCACTCCCCGCCGCA
AGTCCTGAGGATGGCCAGCAGAGAAACAAGAAAATGGACTCCCTGGCTGCTGGAGAGTTGAATGCCAGCCACCAGCCATGGGTGCCAGAG
TTTGTAGCCTATTGGAGGAAAACACACCAAGAATTTCTACAGACAGTTCAAGGAAATTGCTGCAGTTATTGAAACGGTGTGAAGACGGAT
TCTTTGGTTGATAAATTGCTATCATTCTAAAGTCATGGACTTCACTTTCGGCAACAAAACTAAATAAGGATGGAACATTTATTGAATGAA
AAATGCACTTTTGTTTTTCCATTTTTTTAAATAATAAAAATCAGACAAACAGGAACTGGGTAGTGGTGATGAATGCAAAACTTTGTGAAT
GTGCTTTATAAAAGTGATAATTAGACACTTTAGAGGATATACTTGGTGATAATGTGAATGATGTAATCAGACTAACAGTTGAATCATTGC
TGTTGGAGGCAGCACAAATTTATGTGTTACAACAGTAGTTTAAAAACTTGTACTGGATGGAACCCATTTTATAAACAGTCTTATTTGGAG
TCATGTATATAAAAATATATATAAATTAGAAAAGTAGTATTTGATTAGGATAACTTTACAAATTCAATAGTATAGCCATCACTTATTATA
ATGGCAATCAGAAGAGTGAGGCTTCTTTTTTCAAACTTTTGTAATCAGATTAAGATTGACCATTGCTCCTTTACACAGTATTAGTCTAGC
ATTCAATTATTTCTGTTATTAATGGTTGTAGAAAGTTCAAATACATACGCAGAGTTGGAAAGACGAGTTTTAGTCTGAGTTCTGTACGAC
GGAGTTAACCCGTTAGCACAAGTTATTGCATTAGATGATCTCTGTTGAATTTAAATACATAAACCTGTTGTTAAACGCTTTTATACTATA
AAGCCACCACATTGTATGGCATTTGTTTAGAAGTAAGCAAATAGACCACCGGAATAGAATAGATGGCCTAGAAATAGATCAAGACATTCT
GGTCCGCCATATTAGAAATTTAAACCCTCTTCACACCCTGTCTGCATTTCTGCAGGTCTGTGTGAGTCCACTTTCTTTTTTGTTCCCTGC
TAGGTAGCACACAGCTGTGAGGAGCCCAGGACTGCTGCCTGCCGCAGCCCACCTGTGCGCTCAGATTCCTACCAGCTTGATGAGTTAGCT
GATGGGCCATTTGTGCATACCAACTACCCACAGACATTTCTATTACCCACCCTCTGGATGCCAGTGCATTAATGATTCTAGAATTAGGAG
AAACCAAAGATCCCTTCTCTCTCCCTCCCACAACCAGTGTCGTCGTGTTCCTAGAAATAAGAGTAGAAACCCCTCTATCTGGGTTAAAAC
AGCAAACCTGCCTTCTGTAACTGTGCATGAGGTTCCTCTGTCTCCCACTTACTTCGGATTAACACCTTCCTCTTTCCCCTTCCCTGTTTG
CAGGGTAGCATTTCTAGGTTTAAGGCAATATGCAAAAAGACCCAAAGTTAGGCCCTGGCTCAAACACTGTGGGTAGCAGATTTGAAATAA

>11879_11879_8_C5orf56-COMMD6_C5orf56_chr5_131785381_ENST00000407797_COMMD6_chr13_76100775_ENST00000406936_length(amino acids)=127AA_BP=0
MEKQKCIFHSINVPSLFSFVAESEVHDFRMIAIYQPKNPSSHRFNNCSNFLELSVEILGVFSSNRLQTLAPMAGGWHSTLQQPGSPFSCF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C5orf56-COMMD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C5orf56-COMMD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C5orf56-COMMD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource