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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD18B-SNX30 (FusionGDB2 ID:HG441459TG401548)

Fusion Gene Summary for ANKRD18B-SNX30

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD18B-SNX30
Fusion gene ID: hg441459tg401548
HgeneTgene
Gene symbol

ANKRD18B

SNX30

Gene ID

441459

401548

Gene nameankyrin repeat domain 18Bsorting nexin family member 30
SynonymsbA255A11.3|bA255A11.5ATG24A
Cytomap('ANKRD18B')('SNX30')

9p13.3

9q32

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 18Bsorting nexin-30
Modification date2020031320200313
UniProtAcc

A2A2Z9

.
Ensembl transtripts involved in fusion geneENST00000290943, ENST00000426460, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 7 X 6=294
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD18B [Title/Abstract] AND SNX30 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD18B(33550577)-SNX30(115598494), # samples:4
Anticipated loss of major functional domain due to fusion event.ANKRD18B-SNX30 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD18B-SNX30 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANKRD18B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SNX30 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-50-5946-01AANKRD18Bchr9

33550577

-SNX30chr9

115598494

+
ChimerDB4LUADTCGA-50-5946-01AANKRD18Bchr9

33550577

+SNX30chr9

115598494

+
ChimerDB4LUADTCGA-50-5946-02AANKRD18Bchr9

33550577

-SNX30chr9

115598494

+


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Fusion Gene ORF analysis for ANKRD18B-SNX30

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000290943ENST00000604751ANKRD18Bchr9

33550577

+SNX30chr9

115598494

+
In-frameENST00000290943ENST00000374232ANKRD18Bchr9

33550577

+SNX30chr9

115598494

+
intron-3CDSENST00000426460ENST00000374232ANKRD18Bchr9

33550577

+SNX30chr9

115598494

+
intron-intronENST00000426460ENST00000604751ANKRD18Bchr9

33550577

+SNX30chr9

115598494

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000290943ANKRD18Bchr933550577+ENST00000374232SNX30chr9115598494+89672127962822908

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290943ENST00000374232ANKRD18Bchr933550577+SNX30chr9115598494+0.0001576050.9998424

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Fusion Genomic Features for ANKRD18B-SNX30


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD18Bchr933550577+SNX30chr9115598493+2.49E-060.9999975
ANKRD18Bchr933550577+SNX30chr9115598493+2.49E-060.9999975

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANKRD18B-SNX30


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:33550577/chr9:115598494)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD18B

A2A2Z9

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD18Bchr9:33550577chr9:115598494ENST00000290943+1016277_3196771012.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD18Bchr9:33550577chr9:115598494ENST00000290943+1016385_6396771012.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD18Bchr9:33550577chr9:115598494ENST00000290943+1016100_1296771012.0RepeatNote=ANK 2
HgeneANKRD18Bchr9:33550577chr9:115598494ENST00000290943+1016133_1626771012.0RepeatNote=ANK 3
HgeneANKRD18Bchr9:33550577chr9:115598494ENST00000290943+1016166_1956771012.0RepeatNote=ANK 4
HgeneANKRD18Bchr9:33550577chr9:115598494ENST00000290943+1016199_2286771012.0RepeatNote=ANK 5
HgeneANKRD18Bchr9:33550577chr9:115598494ENST00000290943+101667_966771012.0RepeatNote=ANK 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD18Bchr9:33550577chr9:115598494ENST00000290943+1016692_7226771012.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD18Bchr9:33550577chr9:115598494ENST00000290943+1016752_9086771012.0Coiled coilOntology_term=ECO:0000255
TgeneSNX30chr9:33550577chr9:115598494ENST000003742323989_210206438.0DomainPX


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Fusion Gene Sequence for ANKRD18B-SNX30


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4620_4620_1_ANKRD18B-SNX30_ANKRD18B_chr9_33550577_ENST00000290943_SNX30_chr9_115598494_ENST00000374232_length(transcript)=8967nt_BP=2127nt
GGGGGATCTCGAATTTGGAGCTGGGTGGGGGTGGAAAGGCCACGAGGAGCCGCGGCGTCTCAGGAGCGGGTGGTGGGCATCTGAGAAGTC
GCCACCATGAGGAAGCTCCTCAGTTTTGGGAGACGCCTGGGCCAGGCGCTCCTGAGCTCCATGGACCAAGAGTATGCGGGTCGGGGGTAC
CACATTCGGGACTGGGAACTGCGGAAGATCCACAGGGCGGCCATCAAGGGCGACGCCGCAGAGGTGGAGCACTGCCTGACGCGCAGGTTC
CGGGACTTGGACGTCCGCGACAGAAAAGACAGGACTGTTCTACATTTGGCCTGTGCCCATGGCCGTGTGCAAGTGGTCACTCTCTTGCTG
GACAGAAAATGCCAGATCAACATCTGTGACAGACTAAACAGGACACCTTTAATGAAGGCTGTACACTGCCAGGAAGAGGCTTGTGCCATT
ATTCTCCTGAAACGTGGCGCCAATCCAAACATTAAGGATATCTACGGCAACACTGCTCTCCATTATGCCGTGTATAATGAGGGGACTTCA
CTGGCAGAAAGACTGCTTTCCCACCATGCAAATATTGAAGCACTAAACAAGGAGGGAAACACTCCACTTTTGTTTGCTATAAATTCCAGG
AGACAGCATATGGTGGAATTTTTATTGAAGAACCAGGCAAATATACATGCCGTTGACAATTTCAAAAGAACAGCCCTCATACTTGCAGTA
CAGCATAACTTGTCAAGTATCGTCACCCTCCTGCTTCAACAAAATATACATATCTCTTCTCAAGACATGTTTGGCCAAACTGCCGAGGAT
TATGCTTTTTGTTGTGATTTGAGAAGCATCCAACAACAAATTTTGGAACATAAAAATAAGATGCTTAAAAATCATCTTCGAAATGACAAT
CAAGAAACAGCAGCTATGAAGCCTGAAAATTTGAAAAAAAGAAAAAAAAGAAAAAAATTGAAAAAAAGAAAAGAAGGTGCAAAAGCAGAA
CACAACTTAAAAGTGGCTTCAGAGGAAAAGCAAGAAAGGCTTGAAAGAAGTGAAAATAAACAGCCGCAGGATTCTCAAAGTTATGGAAAA
AAGAAGGATGAGATGTTTGGAAATTTTATGTTGAAGAGAGACATTGCCATGCTCAAAGAGGAATTATATGCAATAAAAAATGACAGTCTC
AGAAAGGAAAAGAAATATATTCAGGAAATTAAAAGTATTACAGAAATAAATGCTAACTTTGAAAAGAGTGTAAGACTCAATGAAGAAATG
ATAACAAAAAAAGTGGCCCAGTATTCGCAACAGCTTAATGATCTGAAAGCTGAGAATGCAAGGCTGAATTCAAAATTGGAGAAGGAAAAA
CACAACAAAGAAAGACTAGAAGCTGAAGTTGAATCCCTCCATTCTAACTTGGCCACTGCTATAAATGAGTACAATGAAATTTTGGAAAGA
AAAGACCTAGAACTAGTTTTATGGAGAGCAGATGATGTTTCTAGACATGAAACAATGGGTTCTAATATTTCTCAACTAACAGATAAGAAT
GAGTTGCTTACTGAACAGGTCCATAAAGCTCGGGTGAAGTTCAATACCTTAAAAGGTAAGCTCCGTGAGACAAGAGATGCTCTCAGGGAA
AAGACATTGGCTTTAGAAAGTGTACAGCTGGACCTAAAGCAAGCGCAGCATCGAATAAAGGAAATGAAGCAGATGCATCCAAATGGGGAA
GCTAAAGAAAGTCAATCCATTGGAAAGCAGAACTCTTCAGAGGAGAGAATACGTCAACGAGAACTTGAAAATCTCTTGCTTGAACGACAA
CTAGAGGATGCTCGTAAGGAAGGTGATAATAAAGAGATAGTCATTAATATCCACAGAGACTGTCTTGAGAATGGAAAGGAAGATCTTCTA
GAAGAAAGAAATAAGGAATTAATGAATGAATATAATTATTTAAAAGAAAAACTGCTTCAGTATGAAAAAGAAAAAGCAGAAAGAGAAGTG
ATTGTGAGAGAATTTCAAGAAGAACTGGTCGATCATCTTAAAAAATTTTCAATGTCAGAGTCTCCACTGGAAGGTACATCACATTGTCAT
ATTAATTTGGATGAGACATGGACTTCAAAGAAGAAATTATTTCAAGTAGAAATTCAAGACCTGAACGCCTACAAGAAGCAAGGGATAGCA
TTGCTGACCAGAATGGGCGAGTCAGTCAAGCACGTCACTGGCGGCTACAAGCTGAGGACTCGGCCGCTTGAGTTTGCTGCCATAGGTGAC
TACTTAGATACATTTGCACTCAAACTGGGAACCATTGATCGAATAGCCCAGCGGATCATCAAAGAAGAAATAGAGTACCTTGTGGAGCTG
AGAGAATACGGGCCTGTGTACTCCACATGGAGCGCCTTGGAGGGTGAGCTGGCTGAACCCCTGGAGGGTGTGTCAGCTTGCATTGGGAAC
TGCTCTACAGCCTTAGAAGAGCTGACAGATGACATGACAGAAGACTTCCTACCTGTGCTCAGGGAATATATTTTATACTCTGACTCCATG
AAGAGTGTATTGAAGAAGAGGGACCAAGTTCAAGCAGAGTATGAAGCCAAACTGGAAGCTGTGGCTCTGCGGAAGGAAGACCGCCCCAAG
GTACCGGCGGACGTCGAGAAATGTCAGGATCGGATGGAGTGTTTCAATGCTGACCTGAAAGCTGACATGGAGAGGTGGCAGAACAACAAG
AGGCAGGACTTCCGGCAGCTACTCATGGGGATGGCTGACAAGAACATCCAGTATTATGAGAAGTGCCTCATGGCGTGGGAGTCGATTATT
CCACTACTGCAGGAGAAACAAGAGGCCAAGTAAAGTTCTTTCTTGGGACGGAGACTCTTCTACCTACACAGGGCCTGGCACCCTATACCG
GAATGTCCCTGCAGTGCCAGAGACGCAGTGCTGGGAAAACAACCACAGAAACATCTCTCCTTTGTGTATTTTTCCCTCCCCCACCTTTCA
CCCCACAGTGGTTTTCAATTAGTATTTATTCCATGGTGGAGTCTGTGAGGCTAGAATATCTCTCAGCAAGAGCAGCATACCTCCATGTTG
TGAAGGCATCTGTTCAGTGAAGCACTACGAAAATTTGAAACCAAGGGACAAGACAACCTGCAGCTGACGCTCTGACATTTCATGACAGTT
TCCTCTTTAGGGACAGCTGAGTTGCCAGTTGTGGGAGAGAACCCGGGGCCTGCTTTTCAAGGATGAGGAGGAGGCAGGAACAGAAGGCAG
CTGCTGCTTTCTGTGGAAACCTGGCCCCTCTGGAATTGGCCTCTGTGGGCATTGACTCGTCTTGGCCTAGGAGGCATTGGTGCCTCCCTG
GCAAGTCCTTAACGTACAGTACCTGTAGCTGTGAGTGTGGCCTGCTGCCTGCTTGTGATGAGTGATACCGTCTTACTGTTTCTGTTTCAC
ATAGGGACATTTAAATCAATGTCAATGTGCGTCCATGCTTGAGTGAGCAAGCCAGCGTCCTTGTCCTCCTGCAATGCCTTTGGGAAGCTC
AGGGGAATGCTCCCCAAGCTTGTTTCTGACACTAGAATGCAACAGATTGGAAACTTTTTGTGTAAAATGAAAAAAACAAAGTGCTGGTTT
TTTTTTTTTTTCTGTGAAGGTCTTCAGTGTTTTGCTTGTTCACTGTCATCAGAGCAGGGATTAGACCTGTTAGGGAATATCTATTGTCTT
GAAGTCAGAGTAGCTCCCCATTGTTGAGATCAGTGGGCATATACCAAGCTCCACCCCCAGTGTCAGCTTTGTGCAATTTGCCTTTACCTC
ACCAAAAATACCTACTTTAATATTTCCTCCTGTGTCCTCTGAATGTCTGGGCGAGCTTTTGGTGAGAGGGCTGGTATGTCATGTTGTTAT
GATACAGTCGAAATTTGTCAATGCAGTGTGAATGTTCTACATAAAGTGCTTTAACCCTTAACATTTCCTGGTCAGGAAGGAAAATCAGTA
CCTGGACGGGCCTCGAAAATGACAAATGCAACAGCGAGCCCTTTGTGTCCAGCTAAGCTAAAGTCTCCTCAGTGTGCAGCCAGATTCCTG
GGGACTGCTGAGTGTGGTTACAGGCTGCATTTCAGACAATGACCAGGTTTACTTTTCAGATCACAAAGCAAACAGTCACCAAGGATCTGT
CTTCCAACTCTTTTTTTTTTCTGCTGAAATGAAGCTACATGTCATGTTTGTGTTCTTTCATCTGTGGCTCATCCCTGTAAAACTACGAAT
CTGAGCCTCAAATAAGCAGTAGTTTTTTTGTTGTTTATTTTTAATGAAACAGCTGTGTTAAGGCGCTGCTTCAGATGCAAGTTCACCTGG
AAATACTGGTCAGCGGGCAGCACGTCAAGGTCACTTAAGCCCACTTTTAACTGCAGGTCATCCTCGCATCAGCCAAGGCTGTGGTGCTGT
TGATGCCGCAGTTGGACAGCATAGGACGGCTTGGTTCTGTTTCATTGTGTTTGACAATGTTGCAGTTTAAATGATAATGTTTAAATCAAT
TGGTACTTGCCTGTAGTGTTAAACCCTATTTGTGCCATTCTCAAGTCCTTTGATGTGAATTTTCAGTTTGGTACAGTTAGAAATGACTCA
TTGATGCGGACAGGTAAGAACAACCCATGTACCCCCGAGTGATTGCATGCTTTATTCTACCTCTAAGCCATCGTGTTGACGTGGGTATGG
ACGCCTGGGTCTGACCTGACACTGTGCTGGGAGAATCAGGATGTGTGTCTAATGGCGAGCTGACAGCCCTCTGCTGATATTTGGCAGAAG
GCACCAGACCAGCCCAGCAGCAAATGCTCATCTTTGGGAACATAGGAAGCTTTACCTTGGGGAAGGTATGCTTTACAAATGTCCAGTGTA
ATGAATGTTTGGAAAAAACTGGAGTTACAGGAAAATGAAATCTGACTATCTGCTAGTTGCCAAAACCCAGAAACATTCCTGTGTAATGGT
TAGTTGGGAAAGAAGGCAGCACTTGAAAAAATTTACCAGGTTCCTCACTGGGAGATGTGGGAAGGGGCGTGGGACGCACGCGGTCACTCC
CTCTCCTAGTGAGAGGCAGATGGCTGGCTCTGAAGGGAGGCAGGCACCGTGGGATTTGGGCTTGCTCTGCTTGGTCCCCATGTGATGCCC
TGTGCTGTAAGATATCAGAAAGACCTGGAACAAGGCAAACTTTATGTCCTCCTGGCATGTTATTGATAACAGAGCCAGGAAGTCCAGTGT
ACATTACAGATTTTCTGGGAGAAATAGTCCTTCCAGAGAAAGGATTCCTTCCCAGCCTCCAGGCTGGTGTCTCATGAGGTGAGGAGGCTG
GCCCAGAAGGAAGGGGACGTTAGGTGGTGAAGCAGGCTCCCCTGGGCCTCTGAGGGCCAGCAGTCCCAACCATTTGCCTCTTCGTTTTGA
CCAAGCACAAAAGAGATATTCCCTAGAAGTGTCACACGGAGGCTTCTGTGCCAAAGACTGCCTTGTAGAGGTCTCATCACCTCACACTTC
TTGACTTCACAAAATTGTGGCCCTGAGATCAGTACTCCTCTCTTAAGTATTTATTATTATTATTATTTACTTTACCTCAAGCAGACAGAC
ATAGGTTTTGAGGCTTGAATACATGGCAGTGGAATACAAGGCCCTCCCTAGCAGCCGCCCCAGGCCTGGAAAGTGGGAGATTTCATTCGC
CCGGGTTAAAAATCCAGAGGAAGACAGAAGAGAGGAGTCCTAGGAACTGAGCAGATTTTAGAGACGCAAATGATGTTTAAGAGAGCCTTG
TGATTTGTAGCAAGCATGGGCACTGCTTTTTCTTACTAATGTGGTAGATCTACACGAACATTCTAGGCTGTTCTGCTCAGAGCGAGGAAC
CACTGCTCCTCAATGGGGAGGGAACATACCACCCAGCCAGGCTTAGCATTGGGTTTTATCCTTTAATAAAAGTTTTATAATGAATCCTGT
TCACCTTAAAGTGTGATTATGGAGATGATTGGCTCCATATTCCACCACGTCATTCCTTCAACTCACCAGACACCTTTCTTTAGTTGAAAT
AAACCAGCATGACCTGGAGATCATGGTGACTGTAAGCTAAGTCTGTTTTCATGCCAGATTTCAGCCCCACCCAGAGTGTGCTCTAGATGT
TGTTGATTTGAATGGTTTTCCCAGTTCCCACTCCACATGGGGAAGTTGAATGAATGCACACCTGCTGCTCACTTCTTGTGAGGCTGCCTT
TTGTGATCAAATAACAGGAAGTTCTGCTTTAGAGGAGGGCACGATGACCATGTGGCAGTCTGCAAGTGGAATTTTGGGATGGCAGCCCGA
GGAACATCCAGAGTTACTGTGTGACTTGGTCCTGCCATCGTTAGCTTTGAAATCACAGGCATTGGGCTCTGTTTTGACACCATTCATTGG
ACTGCGGGACAGTCATTCTTTACGTTCTCTCTTGAGCTGGTGAGAGAGGAGGAAGAGGGAAGTCAAGAGCAACCTCCAAGGCCTATGTCA
GCCTCTTCTCCTTGGGTCTTGGGGTGGGTTAGAACTGGGTTCCAGTCTGGCCAGATGGGTTGCTGGCTGCACTGAGGGTGATTCTTCTCA
GAAGATGGGCTGCCTGTGGTCAGGACAGGGCATACCAGTCTGGACTCCACCTTCCCAGACACCTACTTTAAGGACCTGTGGAAACTGGGT
GATCCAATTATAGGGCTGGGGCAACCCTGCTTTGGCCACCCTCATTTACAAACTTAGGTTGGGAGCTTGGGTTTCCTGTCTCACTTCCAA
AAGCCTTCAAGATGGCAGCAGATGGACACACCCTCTCATTTCTTGTGTCTTGTCTGTCAGATGGCAGGAGGCCTGTATCAGTAAATTTGA
GGAAAATGTTCTCTCCTGGGCCAGCCTCACAGCTTGCGTTGGGTGTGTTGGAATTGTTCTCTTCGGCCTTGTTCTGCCTTGTGATCTTTT
CAATTCAGTGAATAAACCAGGAATCCATTTTTTCACCAACCCACCCTGTAGATTGTCAGCTTTTTGTTTGAGAGATGCCTGGTCTCACAG
TTACATGTATCAGAGTGTGTGTAAGTTGTCTGTGTTAGAAAGGTTGGGGTGGGGGCTTTGTTGCAGGGGATTAGACTGTTCTTTCTTCAT
CATAATTTGAGATACATCCTGAGTATGACTGTCTAACCCTTTCTGTGTGGCAGAAAAATATGTTTTCCAGGTAGTTTTTACTACTACAGA
GAGTCTGTAAATAAGTGCTTTAAAAAAATAACAAACCAATAAGATATTTGTCTCCTATATAAACATTCTGTGTATTTAGCACTTGAAAAT
CAACAAATCCAGAATTTAAAAAAATGCCACAGACTTTTCAAAGCCCAACTCTACTTTTTTGAGAATTTGTCCGTACCTACTAATATGCCT
TATTCTTCTTCACCTAGTGTTTTAAAAGTCCTGGGTAGAAAGAGTTTTAGAAATGTAATCAGTTGTTCAGCTTCAATAATATAGAGATCT
AACATAGTCAGTCCTCAGGCCCCCTAAAGAAACAAGCAAGAAAGTGAGGGCCATCACTAGGGTTGGCTTTGGGGAGGGGAAAACTAAGGA
CTGCTTTTGCCAAATGATATTTTTGATAATGTAAGGAAACACAGGGACCACAAAACCTTTTTTTTTTTTTTAAGTGTGAAAGATTAGTGC
CTTTTGGCATACTTTTGATTTTAGAGGATATAGTATCGGCATTGACAAATCACGTAGAAACAAAGAATGCTATAGATGACAACAGTATTA
AATGTTACTCCTGATTCTGCAGAACAGCTTTTGAAGATACTGGGGGGTATCTTCAAGCCTCAGAGCAGCTTGTTTCAGATAGAAATTCTC
TATGGGTTGAAATGCCAAAAACAGAAAACATGATGTTGACTCATGTAATTTAGTCCATTTTAGCAGAGCCTTTAGTGTTAACACCAGTGG
CGAGGAGCATTGCATATTCTCTGTCAGCAGCAGCACTCCCACACCAGGTGGTTCTGGGCTCTCTGTAGGCTGGTCCTAGTAGGTGACACC
CAGCAACACCCCTGTTGGACAGGATTGATTGTTCGCAGTCTTAGACCAACACTTCAGTCAGAAATGTTACTGGGAGGAGGAAAGGAAAAT
CACTTTTTTTCCTCCATGTGGAAATGAGGAGAGAGGAAAGTGGATTGCAAACCAAAATGTGAGTCAGTGTGATGAAGCAGTGGCTCTGTC
ATCTCGGCCTTTATCCAATAACAAACCAGCATCTCTTAAAGGCGCTTTTGGCCTAGACACCCCTGAAGTTTGGATGAAGTCTGGTGGATT
CCCTGTCTGTTGTATTTCTGTGTGCCTGTTCCCTTCATTGCTGTGAGTTGGGAGTGCATTGAGAGATGATGTCCATCTGATATATTCCTG
TGAAATAAACTGCCAGCAAACTTTCTAACTTGTATTTTAACTGTTAAAGAAGAGATTAAAAACTTCGGCTTTGGACATGTCCACATTATG
GACTGTCATCTTATTTTTAAAAGTCATTCTTTACGTTTAAAATTTTAAAATAAAAACCTTCTGAGGTATTGATGTAGTCCACCGTGTAAA
TGTTACCTTCTCTCCATGCTGCCATTATGCCAAAACAAAAGCTGTGATAAAAAAAGTGCTTGAGAGAGTGTGTTGATAAGAAAGTGATTT
ATTTACAGATGGAAGTCTTTGTTTCATGAAGCTACCAAACTTTAAAAAGAATGTCACCCTTTTTTTTGTTTGTTATGGAAACCAGAGATT
GTAAAATGGAAAAAGAATCGTTTTTTTGTTGACTTTTTGATGCTGGCACGAGGTTTTTGTCCACTTTTTTCATATATCTGTGTATAAAAA
AATTGTTGTTTACTATGGAATTAGTATTACATTTTGAGGTAAACAAAAGAATTTGTATTGCTTGATAAATATTAGCTTGTAAATTTAAAG

>4620_4620_1_ANKRD18B-SNX30_ANKRD18B_chr9_33550577_ENST00000290943_SNX30_chr9_115598494_ENST00000374232_length(amino acids)=908AA_BP=669
MRKLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVRDRKDRTVLHLACAHGRVQVVTLLLDR
KCQINICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQ
HMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQE
TAAMKPENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRK
EKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKD
LELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAK
ESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIV
REFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQVEIQDLNAYKKQGIALLTRMGESVKHVTGGYKLRTRPLEFAAIGDYL
DTFALKLGTIDRIAQRIIKEEIEYLVELREYGPVYSTWSALEGELAEPLEGVSACIGNCSTALEELTDDMTEDFLPVLREYILYSDSMKS
VLKKRDQVQAEYEAKLEAVALRKEDRPKVPADVEKCQDRMECFNADLKADMERWQNNKRQDFRQLLMGMADKNIQYYEKCLMAWESIIPL

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Fusion Gene PPI Analysis for ANKRD18B-SNX30


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD18B-SNX30


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD18B-SNX30


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource