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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ANKRD18B-SNX30 (FusionGDB2 ID:HG441459TG401548) |
Fusion Gene Summary for ANKRD18B-SNX30 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANKRD18B-SNX30 | Fusion gene ID: hg441459tg401548 | Hgene | Tgene | Gene symbol | ANKRD18B | SNX30 | Gene ID | 441459 | 401548 |
| Gene name | ankyrin repeat domain 18B | sorting nexin family member 30 | |
| Synonyms | bA255A11.3|bA255A11.5 | ATG24A | |
| Cytomap | ('ANKRD18B')('SNX30') 9p13.3 | 9q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat domain-containing protein 18B | sorting nexin-30 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | A2A2Z9 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000290943, ENST00000426460, | ||
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 7 X 6=294 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ANKRD18B [Title/Abstract] AND SNX30 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ANKRD18B(33550577)-SNX30(115598494), # samples:4 | ||
| Anticipated loss of major functional domain due to fusion event. | ANKRD18B-SNX30 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ANKRD18B-SNX30 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ANKRD18B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SNX30 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-50-5946-01A | ANKRD18B | chr9 | 33550577 | - | SNX30 | chr9 | 115598494 | + |
| ChimerDB4 | LUAD | TCGA-50-5946-01A | ANKRD18B | chr9 | 33550577 | + | SNX30 | chr9 | 115598494 | + |
| ChimerDB4 | LUAD | TCGA-50-5946-02A | ANKRD18B | chr9 | 33550577 | - | SNX30 | chr9 | 115598494 | + |
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Fusion Gene ORF analysis for ANKRD18B-SNX30 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000290943 | ENST00000604751 | ANKRD18B | chr9 | 33550577 | + | SNX30 | chr9 | 115598494 | + |
| In-frame | ENST00000290943 | ENST00000374232 | ANKRD18B | chr9 | 33550577 | + | SNX30 | chr9 | 115598494 | + |
| intron-3CDS | ENST00000426460 | ENST00000374232 | ANKRD18B | chr9 | 33550577 | + | SNX30 | chr9 | 115598494 | + |
| intron-intron | ENST00000426460 | ENST00000604751 | ANKRD18B | chr9 | 33550577 | + | SNX30 | chr9 | 115598494 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000290943 | ANKRD18B | chr9 | 33550577 | + | ENST00000374232 | SNX30 | chr9 | 115598494 | + | 8967 | 2127 | 96 | 2822 | 908 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000290943 | ENST00000374232 | ANKRD18B | chr9 | 33550577 | + | SNX30 | chr9 | 115598494 | + | 0.000157605 | 0.9998424 |
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Fusion Genomic Features for ANKRD18B-SNX30 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ANKRD18B | chr9 | 33550577 | + | SNX30 | chr9 | 115598493 | + | 2.49E-06 | 0.9999975 |
| ANKRD18B | chr9 | 33550577 | + | SNX30 | chr9 | 115598493 | + | 2.49E-06 | 0.9999975 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ANKRD18B-SNX30 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:33550577/chr9:115598494) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANKRD18B | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ANKRD18B | chr9:33550577 | chr9:115598494 | ENST00000290943 | + | 10 | 16 | 277_319 | 677 | 1012.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ANKRD18B | chr9:33550577 | chr9:115598494 | ENST00000290943 | + | 10 | 16 | 385_639 | 677 | 1012.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ANKRD18B | chr9:33550577 | chr9:115598494 | ENST00000290943 | + | 10 | 16 | 100_129 | 677 | 1012.0 | Repeat | Note=ANK 2 |
| Hgene | ANKRD18B | chr9:33550577 | chr9:115598494 | ENST00000290943 | + | 10 | 16 | 133_162 | 677 | 1012.0 | Repeat | Note=ANK 3 |
| Hgene | ANKRD18B | chr9:33550577 | chr9:115598494 | ENST00000290943 | + | 10 | 16 | 166_195 | 677 | 1012.0 | Repeat | Note=ANK 4 |
| Hgene | ANKRD18B | chr9:33550577 | chr9:115598494 | ENST00000290943 | + | 10 | 16 | 199_228 | 677 | 1012.0 | Repeat | Note=ANK 5 |
| Hgene | ANKRD18B | chr9:33550577 | chr9:115598494 | ENST00000290943 | + | 10 | 16 | 67_96 | 677 | 1012.0 | Repeat | Note=ANK 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ANKRD18B | chr9:33550577 | chr9:115598494 | ENST00000290943 | + | 10 | 16 | 692_722 | 677 | 1012.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ANKRD18B | chr9:33550577 | chr9:115598494 | ENST00000290943 | + | 10 | 16 | 752_908 | 677 | 1012.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | SNX30 | chr9:33550577 | chr9:115598494 | ENST00000374232 | 3 | 9 | 89_210 | 206 | 438.0 | Domain | PX |
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Fusion Gene Sequence for ANKRD18B-SNX30 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >4620_4620_1_ANKRD18B-SNX30_ANKRD18B_chr9_33550577_ENST00000290943_SNX30_chr9_115598494_ENST00000374232_length(transcript)=8967nt_BP=2127nt GGGGGATCTCGAATTTGGAGCTGGGTGGGGGTGGAAAGGCCACGAGGAGCCGCGGCGTCTCAGGAGCGGGTGGTGGGCATCTGAGAAGTC GCCACCATGAGGAAGCTCCTCAGTTTTGGGAGACGCCTGGGCCAGGCGCTCCTGAGCTCCATGGACCAAGAGTATGCGGGTCGGGGGTAC CACATTCGGGACTGGGAACTGCGGAAGATCCACAGGGCGGCCATCAAGGGCGACGCCGCAGAGGTGGAGCACTGCCTGACGCGCAGGTTC CGGGACTTGGACGTCCGCGACAGAAAAGACAGGACTGTTCTACATTTGGCCTGTGCCCATGGCCGTGTGCAAGTGGTCACTCTCTTGCTG GACAGAAAATGCCAGATCAACATCTGTGACAGACTAAACAGGACACCTTTAATGAAGGCTGTACACTGCCAGGAAGAGGCTTGTGCCATT ATTCTCCTGAAACGTGGCGCCAATCCAAACATTAAGGATATCTACGGCAACACTGCTCTCCATTATGCCGTGTATAATGAGGGGACTTCA CTGGCAGAAAGACTGCTTTCCCACCATGCAAATATTGAAGCACTAAACAAGGAGGGAAACACTCCACTTTTGTTTGCTATAAATTCCAGG AGACAGCATATGGTGGAATTTTTATTGAAGAACCAGGCAAATATACATGCCGTTGACAATTTCAAAAGAACAGCCCTCATACTTGCAGTA CAGCATAACTTGTCAAGTATCGTCACCCTCCTGCTTCAACAAAATATACATATCTCTTCTCAAGACATGTTTGGCCAAACTGCCGAGGAT TATGCTTTTTGTTGTGATTTGAGAAGCATCCAACAACAAATTTTGGAACATAAAAATAAGATGCTTAAAAATCATCTTCGAAATGACAAT CAAGAAACAGCAGCTATGAAGCCTGAAAATTTGAAAAAAAGAAAAAAAAGAAAAAAATTGAAAAAAAGAAAAGAAGGTGCAAAAGCAGAA CACAACTTAAAAGTGGCTTCAGAGGAAAAGCAAGAAAGGCTTGAAAGAAGTGAAAATAAACAGCCGCAGGATTCTCAAAGTTATGGAAAA AAGAAGGATGAGATGTTTGGAAATTTTATGTTGAAGAGAGACATTGCCATGCTCAAAGAGGAATTATATGCAATAAAAAATGACAGTCTC AGAAAGGAAAAGAAATATATTCAGGAAATTAAAAGTATTACAGAAATAAATGCTAACTTTGAAAAGAGTGTAAGACTCAATGAAGAAATG ATAACAAAAAAAGTGGCCCAGTATTCGCAACAGCTTAATGATCTGAAAGCTGAGAATGCAAGGCTGAATTCAAAATTGGAGAAGGAAAAA CACAACAAAGAAAGACTAGAAGCTGAAGTTGAATCCCTCCATTCTAACTTGGCCACTGCTATAAATGAGTACAATGAAATTTTGGAAAGA AAAGACCTAGAACTAGTTTTATGGAGAGCAGATGATGTTTCTAGACATGAAACAATGGGTTCTAATATTTCTCAACTAACAGATAAGAAT GAGTTGCTTACTGAACAGGTCCATAAAGCTCGGGTGAAGTTCAATACCTTAAAAGGTAAGCTCCGTGAGACAAGAGATGCTCTCAGGGAA AAGACATTGGCTTTAGAAAGTGTACAGCTGGACCTAAAGCAAGCGCAGCATCGAATAAAGGAAATGAAGCAGATGCATCCAAATGGGGAA GCTAAAGAAAGTCAATCCATTGGAAAGCAGAACTCTTCAGAGGAGAGAATACGTCAACGAGAACTTGAAAATCTCTTGCTTGAACGACAA CTAGAGGATGCTCGTAAGGAAGGTGATAATAAAGAGATAGTCATTAATATCCACAGAGACTGTCTTGAGAATGGAAAGGAAGATCTTCTA GAAGAAAGAAATAAGGAATTAATGAATGAATATAATTATTTAAAAGAAAAACTGCTTCAGTATGAAAAAGAAAAAGCAGAAAGAGAAGTG ATTGTGAGAGAATTTCAAGAAGAACTGGTCGATCATCTTAAAAAATTTTCAATGTCAGAGTCTCCACTGGAAGGTACATCACATTGTCAT ATTAATTTGGATGAGACATGGACTTCAAAGAAGAAATTATTTCAAGTAGAAATTCAAGACCTGAACGCCTACAAGAAGCAAGGGATAGCA TTGCTGACCAGAATGGGCGAGTCAGTCAAGCACGTCACTGGCGGCTACAAGCTGAGGACTCGGCCGCTTGAGTTTGCTGCCATAGGTGAC TACTTAGATACATTTGCACTCAAACTGGGAACCATTGATCGAATAGCCCAGCGGATCATCAAAGAAGAAATAGAGTACCTTGTGGAGCTG AGAGAATACGGGCCTGTGTACTCCACATGGAGCGCCTTGGAGGGTGAGCTGGCTGAACCCCTGGAGGGTGTGTCAGCTTGCATTGGGAAC TGCTCTACAGCCTTAGAAGAGCTGACAGATGACATGACAGAAGACTTCCTACCTGTGCTCAGGGAATATATTTTATACTCTGACTCCATG AAGAGTGTATTGAAGAAGAGGGACCAAGTTCAAGCAGAGTATGAAGCCAAACTGGAAGCTGTGGCTCTGCGGAAGGAAGACCGCCCCAAG GTACCGGCGGACGTCGAGAAATGTCAGGATCGGATGGAGTGTTTCAATGCTGACCTGAAAGCTGACATGGAGAGGTGGCAGAACAACAAG AGGCAGGACTTCCGGCAGCTACTCATGGGGATGGCTGACAAGAACATCCAGTATTATGAGAAGTGCCTCATGGCGTGGGAGTCGATTATT CCACTACTGCAGGAGAAACAAGAGGCCAAGTAAAGTTCTTTCTTGGGACGGAGACTCTTCTACCTACACAGGGCCTGGCACCCTATACCG GAATGTCCCTGCAGTGCCAGAGACGCAGTGCTGGGAAAACAACCACAGAAACATCTCTCCTTTGTGTATTTTTCCCTCCCCCACCTTTCA CCCCACAGTGGTTTTCAATTAGTATTTATTCCATGGTGGAGTCTGTGAGGCTAGAATATCTCTCAGCAAGAGCAGCATACCTCCATGTTG TGAAGGCATCTGTTCAGTGAAGCACTACGAAAATTTGAAACCAAGGGACAAGACAACCTGCAGCTGACGCTCTGACATTTCATGACAGTT TCCTCTTTAGGGACAGCTGAGTTGCCAGTTGTGGGAGAGAACCCGGGGCCTGCTTTTCAAGGATGAGGAGGAGGCAGGAACAGAAGGCAG CTGCTGCTTTCTGTGGAAACCTGGCCCCTCTGGAATTGGCCTCTGTGGGCATTGACTCGTCTTGGCCTAGGAGGCATTGGTGCCTCCCTG GCAAGTCCTTAACGTACAGTACCTGTAGCTGTGAGTGTGGCCTGCTGCCTGCTTGTGATGAGTGATACCGTCTTACTGTTTCTGTTTCAC ATAGGGACATTTAAATCAATGTCAATGTGCGTCCATGCTTGAGTGAGCAAGCCAGCGTCCTTGTCCTCCTGCAATGCCTTTGGGAAGCTC AGGGGAATGCTCCCCAAGCTTGTTTCTGACACTAGAATGCAACAGATTGGAAACTTTTTGTGTAAAATGAAAAAAACAAAGTGCTGGTTT TTTTTTTTTTTCTGTGAAGGTCTTCAGTGTTTTGCTTGTTCACTGTCATCAGAGCAGGGATTAGACCTGTTAGGGAATATCTATTGTCTT GAAGTCAGAGTAGCTCCCCATTGTTGAGATCAGTGGGCATATACCAAGCTCCACCCCCAGTGTCAGCTTTGTGCAATTTGCCTTTACCTC ACCAAAAATACCTACTTTAATATTTCCTCCTGTGTCCTCTGAATGTCTGGGCGAGCTTTTGGTGAGAGGGCTGGTATGTCATGTTGTTAT GATACAGTCGAAATTTGTCAATGCAGTGTGAATGTTCTACATAAAGTGCTTTAACCCTTAACATTTCCTGGTCAGGAAGGAAAATCAGTA CCTGGACGGGCCTCGAAAATGACAAATGCAACAGCGAGCCCTTTGTGTCCAGCTAAGCTAAAGTCTCCTCAGTGTGCAGCCAGATTCCTG GGGACTGCTGAGTGTGGTTACAGGCTGCATTTCAGACAATGACCAGGTTTACTTTTCAGATCACAAAGCAAACAGTCACCAAGGATCTGT CTTCCAACTCTTTTTTTTTTCTGCTGAAATGAAGCTACATGTCATGTTTGTGTTCTTTCATCTGTGGCTCATCCCTGTAAAACTACGAAT CTGAGCCTCAAATAAGCAGTAGTTTTTTTGTTGTTTATTTTTAATGAAACAGCTGTGTTAAGGCGCTGCTTCAGATGCAAGTTCACCTGG AAATACTGGTCAGCGGGCAGCACGTCAAGGTCACTTAAGCCCACTTTTAACTGCAGGTCATCCTCGCATCAGCCAAGGCTGTGGTGCTGT TGATGCCGCAGTTGGACAGCATAGGACGGCTTGGTTCTGTTTCATTGTGTTTGACAATGTTGCAGTTTAAATGATAATGTTTAAATCAAT TGGTACTTGCCTGTAGTGTTAAACCCTATTTGTGCCATTCTCAAGTCCTTTGATGTGAATTTTCAGTTTGGTACAGTTAGAAATGACTCA TTGATGCGGACAGGTAAGAACAACCCATGTACCCCCGAGTGATTGCATGCTTTATTCTACCTCTAAGCCATCGTGTTGACGTGGGTATGG ACGCCTGGGTCTGACCTGACACTGTGCTGGGAGAATCAGGATGTGTGTCTAATGGCGAGCTGACAGCCCTCTGCTGATATTTGGCAGAAG GCACCAGACCAGCCCAGCAGCAAATGCTCATCTTTGGGAACATAGGAAGCTTTACCTTGGGGAAGGTATGCTTTACAAATGTCCAGTGTA ATGAATGTTTGGAAAAAACTGGAGTTACAGGAAAATGAAATCTGACTATCTGCTAGTTGCCAAAACCCAGAAACATTCCTGTGTAATGGT TAGTTGGGAAAGAAGGCAGCACTTGAAAAAATTTACCAGGTTCCTCACTGGGAGATGTGGGAAGGGGCGTGGGACGCACGCGGTCACTCC CTCTCCTAGTGAGAGGCAGATGGCTGGCTCTGAAGGGAGGCAGGCACCGTGGGATTTGGGCTTGCTCTGCTTGGTCCCCATGTGATGCCC TGTGCTGTAAGATATCAGAAAGACCTGGAACAAGGCAAACTTTATGTCCTCCTGGCATGTTATTGATAACAGAGCCAGGAAGTCCAGTGT ACATTACAGATTTTCTGGGAGAAATAGTCCTTCCAGAGAAAGGATTCCTTCCCAGCCTCCAGGCTGGTGTCTCATGAGGTGAGGAGGCTG GCCCAGAAGGAAGGGGACGTTAGGTGGTGAAGCAGGCTCCCCTGGGCCTCTGAGGGCCAGCAGTCCCAACCATTTGCCTCTTCGTTTTGA CCAAGCACAAAAGAGATATTCCCTAGAAGTGTCACACGGAGGCTTCTGTGCCAAAGACTGCCTTGTAGAGGTCTCATCACCTCACACTTC TTGACTTCACAAAATTGTGGCCCTGAGATCAGTACTCCTCTCTTAAGTATTTATTATTATTATTATTTACTTTACCTCAAGCAGACAGAC ATAGGTTTTGAGGCTTGAATACATGGCAGTGGAATACAAGGCCCTCCCTAGCAGCCGCCCCAGGCCTGGAAAGTGGGAGATTTCATTCGC CCGGGTTAAAAATCCAGAGGAAGACAGAAGAGAGGAGTCCTAGGAACTGAGCAGATTTTAGAGACGCAAATGATGTTTAAGAGAGCCTTG TGATTTGTAGCAAGCATGGGCACTGCTTTTTCTTACTAATGTGGTAGATCTACACGAACATTCTAGGCTGTTCTGCTCAGAGCGAGGAAC CACTGCTCCTCAATGGGGAGGGAACATACCACCCAGCCAGGCTTAGCATTGGGTTTTATCCTTTAATAAAAGTTTTATAATGAATCCTGT TCACCTTAAAGTGTGATTATGGAGATGATTGGCTCCATATTCCACCACGTCATTCCTTCAACTCACCAGACACCTTTCTTTAGTTGAAAT AAACCAGCATGACCTGGAGATCATGGTGACTGTAAGCTAAGTCTGTTTTCATGCCAGATTTCAGCCCCACCCAGAGTGTGCTCTAGATGT TGTTGATTTGAATGGTTTTCCCAGTTCCCACTCCACATGGGGAAGTTGAATGAATGCACACCTGCTGCTCACTTCTTGTGAGGCTGCCTT TTGTGATCAAATAACAGGAAGTTCTGCTTTAGAGGAGGGCACGATGACCATGTGGCAGTCTGCAAGTGGAATTTTGGGATGGCAGCCCGA GGAACATCCAGAGTTACTGTGTGACTTGGTCCTGCCATCGTTAGCTTTGAAATCACAGGCATTGGGCTCTGTTTTGACACCATTCATTGG ACTGCGGGACAGTCATTCTTTACGTTCTCTCTTGAGCTGGTGAGAGAGGAGGAAGAGGGAAGTCAAGAGCAACCTCCAAGGCCTATGTCA GCCTCTTCTCCTTGGGTCTTGGGGTGGGTTAGAACTGGGTTCCAGTCTGGCCAGATGGGTTGCTGGCTGCACTGAGGGTGATTCTTCTCA GAAGATGGGCTGCCTGTGGTCAGGACAGGGCATACCAGTCTGGACTCCACCTTCCCAGACACCTACTTTAAGGACCTGTGGAAACTGGGT GATCCAATTATAGGGCTGGGGCAACCCTGCTTTGGCCACCCTCATTTACAAACTTAGGTTGGGAGCTTGGGTTTCCTGTCTCACTTCCAA AAGCCTTCAAGATGGCAGCAGATGGACACACCCTCTCATTTCTTGTGTCTTGTCTGTCAGATGGCAGGAGGCCTGTATCAGTAAATTTGA GGAAAATGTTCTCTCCTGGGCCAGCCTCACAGCTTGCGTTGGGTGTGTTGGAATTGTTCTCTTCGGCCTTGTTCTGCCTTGTGATCTTTT CAATTCAGTGAATAAACCAGGAATCCATTTTTTCACCAACCCACCCTGTAGATTGTCAGCTTTTTGTTTGAGAGATGCCTGGTCTCACAG TTACATGTATCAGAGTGTGTGTAAGTTGTCTGTGTTAGAAAGGTTGGGGTGGGGGCTTTGTTGCAGGGGATTAGACTGTTCTTTCTTCAT CATAATTTGAGATACATCCTGAGTATGACTGTCTAACCCTTTCTGTGTGGCAGAAAAATATGTTTTCCAGGTAGTTTTTACTACTACAGA GAGTCTGTAAATAAGTGCTTTAAAAAAATAACAAACCAATAAGATATTTGTCTCCTATATAAACATTCTGTGTATTTAGCACTTGAAAAT CAACAAATCCAGAATTTAAAAAAATGCCACAGACTTTTCAAAGCCCAACTCTACTTTTTTGAGAATTTGTCCGTACCTACTAATATGCCT TATTCTTCTTCACCTAGTGTTTTAAAAGTCCTGGGTAGAAAGAGTTTTAGAAATGTAATCAGTTGTTCAGCTTCAATAATATAGAGATCT AACATAGTCAGTCCTCAGGCCCCCTAAAGAAACAAGCAAGAAAGTGAGGGCCATCACTAGGGTTGGCTTTGGGGAGGGGAAAACTAAGGA CTGCTTTTGCCAAATGATATTTTTGATAATGTAAGGAAACACAGGGACCACAAAACCTTTTTTTTTTTTTTAAGTGTGAAAGATTAGTGC CTTTTGGCATACTTTTGATTTTAGAGGATATAGTATCGGCATTGACAAATCACGTAGAAACAAAGAATGCTATAGATGACAACAGTATTA AATGTTACTCCTGATTCTGCAGAACAGCTTTTGAAGATACTGGGGGGTATCTTCAAGCCTCAGAGCAGCTTGTTTCAGATAGAAATTCTC TATGGGTTGAAATGCCAAAAACAGAAAACATGATGTTGACTCATGTAATTTAGTCCATTTTAGCAGAGCCTTTAGTGTTAACACCAGTGG CGAGGAGCATTGCATATTCTCTGTCAGCAGCAGCACTCCCACACCAGGTGGTTCTGGGCTCTCTGTAGGCTGGTCCTAGTAGGTGACACC CAGCAACACCCCTGTTGGACAGGATTGATTGTTCGCAGTCTTAGACCAACACTTCAGTCAGAAATGTTACTGGGAGGAGGAAAGGAAAAT CACTTTTTTTCCTCCATGTGGAAATGAGGAGAGAGGAAAGTGGATTGCAAACCAAAATGTGAGTCAGTGTGATGAAGCAGTGGCTCTGTC ATCTCGGCCTTTATCCAATAACAAACCAGCATCTCTTAAAGGCGCTTTTGGCCTAGACACCCCTGAAGTTTGGATGAAGTCTGGTGGATT CCCTGTCTGTTGTATTTCTGTGTGCCTGTTCCCTTCATTGCTGTGAGTTGGGAGTGCATTGAGAGATGATGTCCATCTGATATATTCCTG TGAAATAAACTGCCAGCAAACTTTCTAACTTGTATTTTAACTGTTAAAGAAGAGATTAAAAACTTCGGCTTTGGACATGTCCACATTATG GACTGTCATCTTATTTTTAAAAGTCATTCTTTACGTTTAAAATTTTAAAATAAAAACCTTCTGAGGTATTGATGTAGTCCACCGTGTAAA TGTTACCTTCTCTCCATGCTGCCATTATGCCAAAACAAAAGCTGTGATAAAAAAAGTGCTTGAGAGAGTGTGTTGATAAGAAAGTGATTT ATTTACAGATGGAAGTCTTTGTTTCATGAAGCTACCAAACTTTAAAAAGAATGTCACCCTTTTTTTTGTTTGTTATGGAAACCAGAGATT GTAAAATGGAAAAAGAATCGTTTTTTTGTTGACTTTTTGATGCTGGCACGAGGTTTTTGTCCACTTTTTTCATATATCTGTGTATAAAAA AATTGTTGTTTACTATGGAATTAGTATTACATTTTGAGGTAAACAAAAGAATTTGTATTGCTTGATAAATATTAGCTTGTAAATTTAAAG TTTCTTTACTTCAATTAACTTAAAGGACCAATAAACCCATAAAAGATGCTTTCTTTA >4620_4620_1_ANKRD18B-SNX30_ANKRD18B_chr9_33550577_ENST00000290943_SNX30_chr9_115598494_ENST00000374232_length(amino acids)=908AA_BP=669 MRKLLSFGRRLGQALLSSMDQEYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVRDRKDRTVLHLACAHGRVQVVTLLLDR KCQINICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQ HMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQE TAAMKPENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRK EKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILERKD LELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAK ESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIV REFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQVEIQDLNAYKKQGIALLTRMGESVKHVTGGYKLRTRPLEFAAIGDYL DTFALKLGTIDRIAQRIIKEEIEYLVELREYGPVYSTWSALEGELAEPLEGVSACIGNCSTALEELTDDMTEDFLPVLREYILYSDSMKS VLKKRDQVQAEYEAKLEAVALRKEDRPKVPADVEKCQDRMECFNADLKADMERWQNNKRQDFRQLLMGMADKNIQYYEKCLMAWESIIPL LQEKQEAK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ANKRD18B-SNX30 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ANKRD18B-SNX30 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ANKRD18B-SNX30 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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